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<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDB2</accession>
    <name>A0A5N6TDB2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_167067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742562">
        <property type="protein sequence ID" value="KAE8144343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A5N6TDB2"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="305" mass="33579" checksum="B54ABBA3E6266832" modified="2020-04-22" version="1">MLRVPSSTFFRAVPTTTKFCLRTTRPLKTQWLVQPFRGASLPLNPSHRLYSTESTASLPLEAPKPRSRFRRFLGFTSIAVIAFTAGLVYQTQKTVSRMMTTTLPTDEETLTAFAPSEEFTQEVDDFIRNHPLAVSLRENPAFTESRPHLKVPAELRARNLTAGTLSGPGRIVVPPYIFAEDGGKSLVAMFYLGADICGHPGIVHGGLLATLLDESMARCCFPALPNKVGVTANLNIDYRRPAMADAYAVLRAETVKVDGRKAWVQGRIETLPKNGEEPVVLVEAKALFVEPKQAAAMSSLYRITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDE3</accession>
    <name>A0A5N6TDE3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_171714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742589">
        <property type="protein sequence ID" value="KAE8144280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDE3"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000005">
        <property type="entry name" value="Quinic acid utilization activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="876" mass="97625" checksum="B2F79748C1A87377" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDZ2</accession>
    <name>A0A5N6TDZ2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_166488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742480">
        <property type="protein sequence ID" value="KAE8144595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDZ2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="127" mass="14974" checksum="D265F0AB0E412826" modified="2020-04-22" version="1">MRFCFLQDVFTTKRTADSSMQLNEVFVLFILSLSRRKFHPEEILSRRNLHPRSEQSPLKEILNKETQAPNANVQWLEFLLTTLIVIALVELMRRALIRLDQHIHPEPARVRAPVQIRIIHVDPEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE61</accession>
    <name>A0A5N6TE61_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_166299</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="ML742462">
        <property type="protein sequence ID" value="KAE8144655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE61"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="111"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="330"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="657" mass="73057" checksum="17E55824E81AA3C1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEK7</accession>
    <name>A0A5N6TEK7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_166155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742445">
        <property type="protein sequence ID" value="KAE8144736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEK7"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8144736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="136" mass="14905" checksum="E3D19B2A669181DE" modified="2020-04-22" version="1">MFRSAIVRSLRASVPRAVRAPATVQIRAPLARPTQFAPRFAYQGVRLYSAPAGLNKEEVEGRIVNLLKSFDKVSDASKINSASHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKEADALHSVDKAVEYILAQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEL6</accession>
    <name>A0A5N6TEL6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_166581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742488">
        <property type="protein sequence ID" value="KAE8144551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEL6"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="124" mass="14378" checksum="A536B2A3D423CD01" modified="2020-04-22" version="1">MTYFLLYFLTLSVVICGTALYLTRARWLPFISVPDYIFDRLPSSFADDIEAGLTSSQFDISSNVLDGDPRAGLDDQAKREVRRIMKRRRVDFDEARRIYIEQRFAKNNIGVDGRPRDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF56</accession>
    <name>A0A5N6TF56_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_165570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742401">
        <property type="protein sequence ID" value="KAE8145014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF56"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="198" mass="22702" checksum="5CFE2AA84DB50E84" modified="2020-04-22" version="1">MGLTSIITLLYEASALQSPTFTGHLTFFGIPHPGKPHLETAVKVTDRLLPGVLQNMHMTNDDKAQILHRISSCYLILYKFEALKLEWMAYCAAGKLPMPRNFATSYLKAVMEHPNDWTLFVCAAVLTVPHYKLGRFLIDVHGCLHRWKYQRQVILFRLVMGVCILLYEHIYQTRTKPVGKIHMLATTGFTLWHGEFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF72</accession>
    <name>A0A5N6TF72_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742401">
        <property type="protein sequence ID" value="KAE8145015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF72"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="89" mass="9686" checksum="5872F56899B21473" modified="2020-04-22" version="1">MNHVIRGQTAAKGGEVVRMPPLLLHLLFVLFYLFILLLCPAVFSRSYCKKVTWICPWLNPTESLKHVSPSAGGGLLHGIGGEKAVMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF89</accession>
    <name>A0A5N6TF89_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_165533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742398">
        <property type="protein sequence ID" value="KAE8145028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF89"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="272"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="875"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="937" mass="104573" checksum="CEE233725FA03FC6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFH6</accession>
    <name>A0A5N6TFH6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation regulator (Cya5)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_165319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742383">
        <property type="protein sequence ID" value="KAE8145125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1319" mass="150184" checksum="79544FE1DA47E1A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGB3</accession>
    <name>A0A5N6TGB3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_164787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742351">
        <property type="protein sequence ID" value="KAE8145382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGB3"/>
    <dbReference type="SMR" id="A0A5N6TGB3"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="113" mass="13168" checksum="166C328682DEBC1C" modified="2020-04-22" version="1">MSRKLAPEANRILFVKNLNYNVTAEQLFDLFGKFGPIRQIRQGIANNSKGTAFVVYEDVHDAKQACDKLNGFNFQNRYLVVLYHQPEKMLKSKEDLAERQENLERLKQQHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGF6</accession>
    <name>A0A5N6TGF6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_164719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742347">
        <property type="protein sequence ID" value="KAE8145423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000494">
        <property type="entry name" value="Sister chromatid cohesion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="9">
        <location>
            <begin position="1374"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1712"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1712"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1750"/>
            <end position="1763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1775" mass="197940" checksum="2BCE6D2009EBD204" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH11</accession>
    <name>A0A5N6TH11_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_164256</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="ML742328">
        <property type="protein sequence ID" value="KAE8145616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH11"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="106"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8145616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="500" mass="55383" checksum="AF04DB9CCF19853B" modified="2020-04-22" version="1">MSKGKLTGAAVAQHNSRDSCWVIVHGKAYDVTEFLPEHPGGQKIILKYAGKDATEEFDPIHPPDTLDKYLDSSKHLGEVDMSTVEQEEKVQDPEEDERQERIKRMPPLEACYNLMDFETVARDIMKKTAWAYYSSGADDEITLRENHSAFHKIWFRPQILVDVENVDSSTTMLGSKASIPFYVTATALGKLGNPEGEVVLTRAAHDHNVVQMIPTLASCSFDEIVDAKRGDQVQWLQLYVNKDREITKRIVQHAEARGCKGLFITVDAPQLGRREKDMRSKFSDVGSSVQASGGGSVDRSQGAARAISSFIDPSLSWKDIPWFQSITKMPIVLKGVQRVEDVLRAVEMGIDGVVLSNHGGRQLDTAPSGIEVLAEVMPILRQRGWEDKIEIFIDGGVRRSTDILKALCLGARGVGIGRPFLYAMSAYGQAGVDRAMQLLKDEMEMNMRLIGASKIEDLNPSLIDVRGLVGGHHAPVPSDTLNLRAYDPLQAPRFSEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THE2</accession>
    <name>A0A5N6THE2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_62253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742313">
        <property type="protein sequence ID" value="KAE8145794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THE2"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="452" mass="51479" checksum="1EDB40E0007F4607" modified="2020-04-22" version="1">MTMDPSFRSSLPALLSSSPSKQVPASSPYGSDTFEPTSLGITADKSIANPKRSGNVTQYSSREAIQSHRADKHRRHLILDPASLDRSRYRPGHKHKHDKFRDSRFPRTMSSIASSTYNRGLLPTWPEVREKEGTLDYGQGLLRPMIRETNRSGWGSESTTGLATGSRKGSILDGMDQTQNSGLIRRREIRSLNDLEQIKDRRQQAEHFLRSALSIIRTLATDITRRLDYTYYNLLEKLAALHSTIDSFQELSDSTSLLFENFERETSGLDQDLRRQTSDLREFQPQIQKTEALEERMRTGKERAETLSGRLAEMRKEIDLWERREIECQTRISRRLRFIWAVVATGILTFVLALIIQNWVIVRPPSFDLDSESATLTIDSVQLPAHQTGKSECYTGKSEHHKKEYLRSPYPSKLIACHSSRYSTVLTASTSTRGNGNMGPLDQDPLKIFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIX7</accession>
    <name>A0A5N6TIX7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2 type zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_162772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742272">
        <property type="protein sequence ID" value="KAE8146306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIX7"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24353" checksum="11C741CA7037D3DC" modified="2020-04-22" version="1">MPSSQFHCRFPGCTSSYRRKEHLHRHEAQHSGSLARTCALCNRSFSRSDTLRRHVRRDHEHPHRQTARAAQACRQCRSAKVRCRGGAPCAQCRLKDNPCVFDDPVHEPSSSQESLVATGQPAVVDAAESEDAGSTDRIQQYVLRYFVHFHPHWPVLHRSTFSIAHEPPLLVQAVLMIGLWVSRTPSAQQAALDLHGKLGLSILAQKVVFSSSSSSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ18</accession>
    <name>A0A5N6TJ18_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_52294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742269">
        <property type="protein sequence ID" value="KAE8146346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ18"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="389"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="482"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="486"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="631" mass="71369" checksum="A50869651DC91A6D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ86</accession>
    <name>A0A5N6TJ86_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_132954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ML742264">
        <property type="protein sequence ID" value="KAE8146415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ86"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="360" mass="41549" checksum="104B96A5899F3DC9" modified="2020-04-22" version="1">MNRSVFDIQPIGRFYGSNTTIRRPKEITCFSYDDQHRFHLGDSSLRYYYPPRLPADLNRGFDSFQKLDDSSDEHLDALLETIMSLEQETGKQCEAEIITWRGMMTKILTAPFDHMNGFEMNATSFHNNVYKNQQKQLQKNQTMPPGMPSQDLMAYWGYKFETLSLLNHPWDLTTREEIEARDELVVNNNSQYCSVVRTGIGKTRLVIGGEVDAIWDCKPDRKEDPIHWVELKTSAEVKNGRDMVKYERKLLKFWAQSFLLGVPKIIVGFRDAFGIVRHLEEIETAGIPNKVKAGKGTWDGNICIKFASDFMEWLRCTISEGGTWRIRKAEKSSVIEVFRIEESGTGDIISPRFSAWRSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJI0</accession>
    <name>A0A5N6TJI0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_162833</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="ML742275">
        <property type="protein sequence ID" value="KAE8146259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJI0"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="473"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="522"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8146259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="553" mass="59720" checksum="3AC2EA5B31D03479" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJR7</accession>
    <name>A0A5N6TJR7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_132783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742252">
        <property type="protein sequence ID" value="KAE8146603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJR7"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="346" mass="37035" checksum="A0804A6273576FFA" modified="2020-04-22" version="1">MSKQTVFRFPTRTSFDDLVSCEEGIPTPSKHEVLIKIRAMALNSRDLQVAKNTYAFPVSDNLVPCSDGAGDIVAVGEAVDDLKEGDRAVISFNTAHFYGTQKSWLTCQGGYIDGVLAQYVTRPASSVVKVPTTARQSYSELVSLVCAGVTAWNGLFGNVPLKPGQTVLVQGTGGVALTALAIAKAAGATTIVTSSSEAKLALVKEKFQPDYCINYKEFPDWAGKALELVGDQGIDHIIEIGGAGTIEQSLKAIAYGGVISVIGYLSQYDATKMPNVPLLALAKGTNVRGILIGPKYMLEDLVTFVDRTKLALPVEKEFRYTRDDVVAAYKELESGAGIGKLCIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJW8</accession>
    <name>A0A5N6TJW8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_143569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742254">
        <property type="protein sequence ID" value="KAE8146570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJW8"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="223" mass="25196" checksum="11002C86DE0307EF" modified="2020-04-22" version="1">MTKADFYHSIAGEYQTAYSDDPVILSFIDKALHYLPPHAHTLDMGCGTGNPLDIALAAAGHKVKGVDISPSMIEQVQTNVPNGTFVLQDMHSYQHPKTEPLDAVFNCRALFHHNRQRNEDCIRNWGRWLPRGGLLCMVVLTADDYNPAKIQEYDADGLFARVRRRFMGKDEIHMLPSRQGLKCLLKESGLEVVDEMEGLFVPPEWTDSDEAAQYCFIARKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKA8</accession>
    <name>A0A5N6TKA8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_143361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKA8"/>
    <dbReference type="OrthoDB" id="4462933at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024935022" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="348" mass="37986" checksum="E05CD7AEDD36C81A" modified="2020-04-22" version="1">MHSKTTLAQAFLAALASPLGAWASSEYTRVCSGPQTHTKNVDSQEFTFHCATSWAHYHSYVSNIATPEDCARRCTASPACAAVVWDSGAKTCWISDNGDGSTIGAPGAVLMRPGSGAQVPCKDQVDQCNSDKIALEQDVETHKKKATDCETKGNTCATSLGTCISDKATCDQEAGKVQQEKAALEQEVETLKHKVTDCETKGNTCSTSLGTCTSDKATCDQKLNQVQKELDDLKQKEKDKNQATQVPANFVPAKNDDGREVIIGGKRWKIYYGKLNDPGHWDLRNGNPRADTYVKCMEDCAANYPKCVRAAWVNDDRTQKYCWHRSHGQNTVQTVSKPWTSTHLIGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKR2</accession>
    <name>A0A5N6TKR2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_143230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="ML742235">
        <property type="protein sequence ID" value="KAE8146933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKR2"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="12"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8146933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="39651" checksum="6BFF706458936931" modified="2020-04-22" version="1">MAEETNPSFVLRSIKDLAFEDRPVPQLQDPWDVRLQVAQTGICGSDVHYWQRGRIGDFVLKSPIVLGHESSGTVVEIGSAVTNLRIGDRVAIEPGIPCRHCEYCRSGSYNLCPNDRFAATPPHDGTLSKYFLTQADFCYRLADHMSMEEGAVVEPVAVACQITKVGDVRANQKIVVFGCGPIGLLCQAVSKAYGAGKVAGVDISVARTEFARTFGADGVFVPPARPDEFGEEEWNEHVARVIKEQFELGDGADVVLEATGAQACIQTGVHLTKKGGTYVQAGMGRENVVFPITAACVRALTIRGSIRYSAGCYATAVDLIASGKVDVKRLITDRFRFEKAEQAFELVKQGKESVIKVVIEGYKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL55</accession>
    <name>A0A5N6TL55_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cwf18 pre-mRNA splicing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8147010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL55"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="195" mass="21550" checksum="E771D64461534ACA" modified="2020-04-22" version="1">MSSNHATLDAAATERKARLAKLAALKRKQPEPDPLTESQTGDVELEDAAPEATATFLSGRNYDAETRGPKLGFDQAPADGQVTVELQAAEIAKDIAEQAKKDEDGEQPIDLFKLQPKKPNWDLKRDLEEKTSTLNVRTQNAIARLVRQRIEDAQHTAKLKRASGEQSGEDVGIEGEMLVEGIHVREREEREDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL86</accession>
    <name>A0A5N6TL86_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_161574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL86"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="408" mass="46275" checksum="F5D5B78A010E7446" modified="2020-04-22" version="1">MRPNWPIIRRRRLRTATAIILLLTSLLEVLRVKHALLQQFTPGPYSSSPSSSSLSFKGEKIFITGIHWNNEQILRDAWIPALVELASAIGRENVFVSIQESGSWDDSKGALRALDQQLAEHDIPRRIILDETTHRDEISKAPGKQGWIETGRGVELRRIPYLAGLRNLVLQPLYELLGNGVVFDKVLFLNDVVFTTNDIRKLLATRGGQYAAACSLDFSKPPRFYDTFALRDAEGHDMLMQTWPYFRARASRHALKHSQPVPVASCWNGAVAMDASPFYEKPALRFRGIPDSLAKSHLEGSECCLIHADNPLSRNLGVWLNPNVRVGYNTLAYDAVNAPDRLWLSSLAVLGGLWRNRLLRWFSTPWFKESVVRGRLDAWEKKEGRREEGAFCIVNEMQVLVENGWAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLE6</accession>
    <name>A0A5N6TLE6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLE6"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="449" mass="48554" checksum="0BE8FDE3359837A3" modified="2020-04-22" version="1">MSVQAAWDACSKTDTLFILVCSVFCWLIIPAVGLAYSGYSTRFNSLASFYPGLLAVAVCSIQWWMLGYSLAYGEGNAFFGGLGKAFHFGVLADPVGSIPEILFSEFQLIFCATVCAIAIGGACERGRLLPLIPFIFLWCTFIYAPLAHMVWSETGFLANLGALDFAGGTPVHICSGATATALSLYLSYPLFRSKRSSIRTPQHLVLHKPHNAFCQLLALIIIWNAWLAFDAGTTLALNFKSVMAACVTNLCAASGALTWAGLTYYETGKWSLDSTFLGAIAGLVLITPSAGFIDMSTAFGFGILGASLGRQALRIKFTKRAALLRWVDNGDTFATHCLGGFLGTIVTGLFARREVAAYDGVTVITGGCVFDGNWRQLWVQIVEAVIGFVWSFGGSYILYALVDCVPGFEVLATDEDIIRGMDASQMGESLHAAQWDDEENYHPFKGIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLM1</accession>
    <name>A0A5N6TLM1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_36675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742218">
        <property type="protein sequence ID" value="KAE8147238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLM1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024889460" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13393" checksum="A7D336DCED662643" modified="2020-04-22" version="1">MITVHNLMVYLLPWTLVQTFRACAQGTHCQDPHMSTKGKRDGQQFTAFAPHPLLHPEIGRKLSFDCIPFSIPIQTSGVLLALCIQGDSQTPCPGATWPVSSQTMICIFHIAPLAELQELHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM56</accession>
    <name>A0A5N6TM56_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742208">
        <property type="protein sequence ID" value="KAE8147433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM56"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024924154" description="Peptidyl-tRNA hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27865" checksum="515B32933801A79F" modified="2020-04-22" version="1">MRFIQLLPILPALAVAQEQVPLANRVQGWFDKAKSYLPTATPVVPAVEKVVEQKIEQKTVTPFNLTNYQTLLRPTSEAQDWLVYITGGNKTCFGRCGHADKSFNESVLMFSADPTSPNLGYLNCESNQVLCSAWSAAAPSAWYFQVPAQVGEERPATSLRTVYLNATTVTPEAIYQIHSEKLYEKRPAYDGALHPTDGWLAQNGLLVPVGYVIYGFSAIPSWLFMVFISFFSRTMMSRRMGNTGGAPAARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM77</accession>
    <name>A0A5N6TM77_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742206">
        <property type="protein sequence ID" value="KAE8147462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM77"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="390" mass="41741" checksum="A2BBCD3EB37E93BE" modified="2020-04-22" version="1">MSGINKVFKEGWHPKGKEGKKESWRGDFKGINQVAGWMGKGKDKDDEREEHVSRPLSALKDPASFGPPPKHIKYHGAAAVPNQTTPDRSGLGAPLSQEQIHEQNVRQQQETESEAEPQKPAPPPLPYRANRTGVDPSTLPPPPVRRVESPADSAPAPVRNKPSIPPRIPPRTNSTSPSHPPTPPPAYSSQPTSEQTSDGYLNQGATSRLAQAGVSVPALGIGNRSNSPATTNLPVNELQSRFSQMRTGSTSTSPAPPPPVRGDSYSREGTTGSSLNAQSATSSIKDFREKHDDKIQAGKQKLSGFNEKYGISQRVNNFFDDRKGSTNSDQAPPLPPHPNLNRSNSSVDSASIARKKAPPPPPPKKAGMRAPPVTASSPSPPPVPLSTKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TME3</accession>
    <name>A0A5N6TME3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_169096</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ML742205">
        <property type="protein sequence ID" value="KAE8147487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TME3"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024890658" description="chitinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="34"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="412" mass="46286" checksum="1906B14F23A984A8" modified="2020-04-22" version="1">MLAFIFLLSNLLWLAHAAIIPRGNETTAKPNPGYISMAYYASWTVYSDHHPQDIPAKSLTHILYSFANITETGEVYFTEPDLHYQKRYPGDSISDDKNNVYGCIKHLKVLLSIGGYTYSQGWDKILKEEKHRKTFATSAVDLMQNIGYDGIDIDWEFPTTNSSVADMVKLLKGVREELDKYHRENAGGERFLLTIACSAGPLNYKPLNIPEIDKYLDYWNIMAYDYVGTWSKIVGHGSNLYPSKSDPLTTPVSSEEAVKYYIDQGVAPKKIIFGMPIYGRAFNTTGLGGNFTSVGIGSHEDGVWDYKVLPLSGTAKVTELLDIGAAYSYDPTHKMFITYDTVNVTKVKAEYIKKRGLGGGMWWETSGDRRREGSLITTLVQSLGGQKALEATDNHMHFPKSKYDNVRNGWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TML7</accession>
    <name>A0A5N6TML7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SprT-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TML7"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="507"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="707" mass="79779" checksum="398F66F79BEDA878" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMU7</accession>
    <name>A0A5N6TMU7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_160396</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="ML742208">
        <property type="protein sequence ID" value="KAE8147431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMU7"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="63"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="469" mass="51203" checksum="AEDDE30F3A53E561" modified="2020-04-22" version="1">MCPGADNEPNGHANVANGQSNVNGEHPGFTAVETRQNPHPSVSRNPYGHNVGVTDFLSNVSRFKIIESTLREGEQFANAFFDTEKKIQIAKALDDFGVDYIELTSPCASEQSRADCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSSYLREHSHGKDMTYIKNTAIEVIEYVKSKGIEIRFSSEDSFRSDLVDLLSIYSAVDKVGVNRVGIADTVGCASPRQVYELVRVLRGVVSCDIETHFHNDTGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMMVADPQYVKSKYKLEKIKDIEDIVAEAVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIINPADFGMTRYVHFASRLTGWNAIKSRAQQLKIEMTDAQYKECTAKIKALADIRPIAVDDADSIIRAYYRNMQSGENKPLLDLTAEEQAQFVAKEKELAAAAGGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPD3</accession>
    <name>A0A5N6TPD3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_158717</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742169">
        <property type="protein sequence ID" value="KAE8148218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPD3"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="18">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="17">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8148218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="54624" checksum="5EEFA1C4168A4A7C" modified="2020-04-22" version="1">MAVAVAKDDMDYTIKPEAGTSNISTSDWPLLLKNYEKLLVRTGHFTPIPAGCSPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDENSGMVTLHDVLDAQWMYDNQRDESYLRKVIKPLETLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRFEAGIDVNEEVVLMTTKGEAIAIGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEATPVKWKNDYKDYSAPEDATGQPAAETTKDSTVVASAEQDEAPSSPQNKMDVDDSNEDDKKKRKRHDGETPEERAERKRKKKEKKEKKERRKSKQDKEDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPS9</accession>
    <name>A0A5N6TPS9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_158558</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ML742165">
        <property type="protein sequence ID" value="KAE8148334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPS9"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="19">
        <location>
            <begin position="223"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8148334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="518" mass="58568" checksum="EBB7916C923BB48C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQE9</accession>
    <name>A0A5N6TQE9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQE9"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="143" mass="15042" checksum="8746E84C64C28CDE" modified="2020-04-22" version="1">MPATKQEISLLINPLVPESVQHNNRILSNLHSLTSFLLGLTAGILALQSATGFLFYLSGTVVVSALFHVLLLSRSGGQGAGVFFPGPNMGEIDGIDMKGFVWGGSREVSRKGSWRDVWLGGGVFGEALSGFVLGWAGVGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQL3</accession>
    <name>A0A5N6TQL3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBF/Mak21 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_158274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742161">
        <property type="protein sequence ID" value="KAE8148411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQL3"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="314"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="62305" checksum="18246527454D9746" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQM6</accession>
    <name>A0A5N6TQM6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_157888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742151">
        <property type="protein sequence ID" value="KAE8148666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQM6"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="328" mass="36140" checksum="A4C2D2C7853D67CF" modified="2020-04-22" version="1">MTTPDVFRDAEYIADVSGIPHGNVADLTGRPSGADSHSKKLQSTAKLALIDRLLRDVDILIYCQLSALYYMDCSIILFAIRAIVQLIFFTPKAPPFDPTRNQPFIGAIFASNLFCMVHHNFFGQPEAGEATRGYLHGGLLIDFIGEKAPVSVVRLLLSDLLVLFLNLVMLGLVVERVKTSEATTSTTPTTSGATETPSNQDHDSEERGILRRRSTSDGVELDELRRRHDSSDSDTDEPLERTQLLADPSESGLAPGSRDGHALDVYASGEAVVMELGLLDVIRDQWRYSPAVARRTSPYVPSNHTAAFLRQRFGLRVNAEGRLERITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQT9</accession>
    <name>A0A5N6TQT9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_12575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQT9"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="599" mass="67452" checksum="6F6DCE7EDF57F437" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQX9</accession>
    <name>A0A5N6TQX9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_157633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742147">
        <property type="protein sequence ID" value="KAE8148768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQX9"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="77"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="465" mass="52370" checksum="0CEFE7E909389C27" modified="2020-04-22" version="1">MFPGHPISKLISKHPTPSYTRLPRYTSPRFRIPRARTMSTTAPRADPFRPARRVAGQRQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPQFAIDAAKEALDRVECNQYSPTKGRPRLKKAIADAFSPSFGRTLNPETEVTITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYISNIEMPGGTIRYVPLHPPKDGATRTSPASEWTIDYQELESAINPKTKMIVLNSPHNPVGKVFSREELEKIGELCIKHNLIILSDEVYDRLYYVPFTRIATLSPELYERTLTVGSAGKAFYATGWRVGYLIGPEHLIKYVAGAHTRICYSSVSPLQEAAAVAFEQADKTGFWEESRTEMRNKMERFCEVFTELNIPYSDPEGGYFVLANMASVKLPEDYPFPPHVASRPRDFKLCWFLIHEVGVAAIPPTEFYTDANARIAEDYLRFAVCKNDDVLETAKERLRGLKKYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQZ8</accession>
    <name>A0A5N6TQZ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine alpha-hairpin motif superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_158033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQZ8"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="82" mass="9732" checksum="31F161529A651404" modified="2020-04-22" version="1">MSSSSDSSPQSSGQDHPNSWSQTEQKFTNKSASEYYDPCQDFADRSLKCMKRNNFDREMCHDYFQAYRDCKKQWLTQKKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR65</accession>
    <name>A0A5N6TR65_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_157558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742146">
        <property type="protein sequence ID" value="KAE8148787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR65"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="660" mass="75477" checksum="91EED8D16FD2AA14" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR88</accession>
    <name>A0A5N6TR88_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_157403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR88"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="134" mass="15621" checksum="9ACEEF774711175E" modified="2020-04-22" version="1">MPVFQNKTFRRATTVSSSLSERIGEAYRAKLPRHPFLLFGFPFVMIIVAGSFVLTPAAALRYERYDRKVQQLDQEEAMALGLRGPDGEEGIKRNPRRRVIGDEREEYYRLMAKDLDNWEQKRVQRFKGEPDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRA1</accession>
    <name>A0A5N6TRA1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_168209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRA1"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="32600" checksum="BBCB19F66A66938F" modified="2020-04-22" version="1">MSTVERDHRRKPSSLRSIIAGSTAGAIEIAITYPAEFAKTRSQLNRKLPDGKKLPWPPFGKQWYAGCTTLIIGNSLKAGIRFVAFDKIKSFLQDEDGKISGPQTVIAGFGAGFTESLLAVTPFESIKTQLIDDRKSANPRMRGFLHGSKIIYQERGIRGFFQGFVPTTARQAANSATRFSSYTMLKQMAEGYVAPGEKLGTASTFAIGGMAGLITVYVTQPLDTVKTRMQSLEASKNYKNSFTCAARIFRDEGMLTLWSGAVPRLARLIMSGGIVFTMYEKTIDMLDTMDPGRRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRF4</accession>
    <name>A0A5N6TRF4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_157745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRF4"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000294">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="530" mass="57513" checksum="AEB4FBDF6E7FF629" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRH3</accession>
    <name>A0A5N6TRH3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_141489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27705" checksum="62B4A4140E9CEA81" modified="2020-04-22" version="1">MSDTESTQSNSTQSTTTKPASQTFPLAYPPPQKNGLRLSSRLILQIQQLNSTQQRALPILDIYQPSIWGKSVGKRRKLTNRDIYIAQTESYAHLPGDDAKTPNTNAHVVGAVYTPVREGTGRVCFPFGEREWEVSSGEKGYRFVCAESGRVVEWEKRGSRPSSSGSGNEAKGERFALRIADSKQSALRRSWLATMTKKGLKVGGWDRVQRDYLLSALGVKDGDEDAALYTCCLTMGVYVASQEGWLNQYV</sequence>
</entry>
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    <accession>A0A5N6TRP3</accession>
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        <name evidence="7" type="ORF">BDV25DRAFT_11954</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742146">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
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    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
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        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="534" mass="59733" checksum="EA45E3EBA2948553" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSD2</accession>
    <name>A0A5N6TSD2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSD2"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="556" mass="61052" checksum="8BAB3C0E3DE6C163" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSH0</accession>
    <name>A0A5N6TSH0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_156747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1937912at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:histone H3 acetyltransferase activity"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
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    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="74"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="317"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8149250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="47447" checksum="3BEB035DE09A0A7B" modified="2020-04-22" version="1">MDEAELQSFPIDSVQNPLVAKRMASEEPNAAPDAKRIKSFHDDETPPVIKPSAITRIVPFPEKPAVIEERNGEIEFRVVNNDGSTESTIILTGLKNLFQKQLPKMPKDYIARLVYDRTHLSLAIVKMPLEVIGGITFREVRHRKFAEIVFCAVSSDQQVKGYGAHLMAHLKDYVKATSPVMHFLTYADNYATGYFQKQGFTKEITLERSIWMGYIKDYEGGTLMQCSMLPRIRYLEVGRMLLKQKEAVLARMRPLSRNHIIHPPPQQWANGVITLIDPLSIPAIRAAGWSPDMDKLAREPRHGPHFNELRHFLSKMQAHKQAWPFLTPVSKDEVPDYYKVIESPMDLSTMEERLENDSYSTPKDLVNDLKLIFSNCRKYNDATTVYAKCAIKLEKYMYSLIKDIPEWFDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT11</accession>
    <name>A0A5N6TT11_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_140749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742121">
        <property type="protein sequence ID" value="KAE8149492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT11"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="254" mass="29482" checksum="9B839CDEE7AA4183" modified="2020-04-22" version="1">MKRQQQDSSTTAQEEHGLDNRLRKRVCKACDRCRLKKCKCDGDSPCSRCREHGLTCHYGERRRVHDKVYPRGYVEMLEQQQQWLVDSLRKLYQRVNEGQEWSGAHLQFQSNGYPLIHDLVSHLGALERRTHDEPEKEAVTNQITDASNVTSTQQDRLHPTPSSPDSIVKPSSEPPASKQWSQQAESLDFSFQLPETSFDFFMQSEFTLEDESLDPWQPLPQWPENFDCFHGIDYTLGDECMNPPFDDLSLIQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT74</accession>
    <name>A0A5N6TT74_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT74"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="226" mass="25154" checksum="A636D6F2573D87ED" modified="2020-04-22" version="1">MDLTTAATFRHNSTFECGFVEGADAGFRKRKACPFFQVELEWTQSTLRSDPNGKQFAHGGGVVLTPLSDSDEKSPAQLQQALAQCDAELAEYKRRFGSIGNGNKPERPAPPRGWPSTLDYTNKGCTPTNHKKTITVYPRLYEIHHNHNLEGSKILGDIVVDNIRDCAVKCADLPGHERCAGASFYILPNHNPKCILYSEMRNIHPAAYARTQTNCMLVEISAYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTL0</accession>
    <name>A0A5N6TTL0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTL0"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="446" mass="47958" checksum="1333D3218D314047" modified="2020-04-22" version="1">MKKTLLIVFVHGFKGGNDTFGCFPEHVRSLLDRSLPSVTVATVVYPKYETRGDLRESVAQFRDWLQNQVIDLEVANRTASPTVDPSVHVFLFGHSMGGIVAAETLLLLASEQPIPPKPAASNSEATSGSQVLEPASFMFPHIQGILAFDTPYLGIAPGVVSYGAESHYKNATTAYNAVTEVAGLFGFGGSSSSSSSKANQGAVGNKSLPPQQNSATMPSSDAAETPSWQKWGRYAMFAGAAGAVAAGGAAAMFSQRQRLTDGWGWVSSHLAFVGCLARPSDLRQRISLLSEVYRDRGIGCTNFFTALGKNATALVETSNQGKTSISQRIIRSKYRTFCTLPPEVENDGFTYDPKSGMGWVKAVNDRATDEIQAHTSMFEPRENPAFLGLVKEACKVVVNSLDRGWYTTATGPVEEVDSDVPRTETATTPADTDNRFMDGDDVVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTT9</accession>
    <name>A0A5N6TTT9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium ion channel Yvc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_155755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTT9"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="258"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="641" mass="73989" checksum="E3196AD87B318E75" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTV3</accession>
    <name>A0A5N6TTV3_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_122070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8149793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTV3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7136"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024959004" description="DUF7136 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30723" checksum="802883AC232FEF6A" modified="2020-04-22" version="1">MSLVLLLCYCALLTFRCADADPYTPQTIELDLVFPRNDTYTRSANFPIIMGLQNAQVAWPQGVLWDWKLERLDEESLPLHGTFPPRSYYFDNQLYTRGEAPSDPFFHYHFPADLQDVLYGQWRYSWRFGFWQNCSFVGAYSRNNFRYQPHQEIIFSIGSSGRPLDLQDVMQQCPGVPVALEITDSILNVLTGLENCPVVNETAPTPNPCALKLNQTIVDNITATVEEMRGCKRGSLANLTDVCESAAPRVQLTGGPGLLAGLLGMVFFLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU73</accession>
    <name>A0A5N6TU73_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_172533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8149908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="275"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="609"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8149908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1416" mass="156110" checksum="CB6F9C4F7E4C119E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUB2</accession>
    <name>A0A5N6TUB2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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            <dbReference type="PROSITE" id="PS50948"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAE8149880.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="270" mass="29419" checksum="ABD890788F5408C2" modified="2020-04-22" version="1">MASSYFPIFMLIIFILALQFVTGQGGCPARLTGVSDNFEIVENPACPDDNGKAVVLEDGTHLFIQCCTHESANAQGLKTIGRVKSRKDCASKCFSDQNPTCDSVMYNTKNGDCALYTLGSFSSKKCDANDDHDWLFFTDPPPQEVPMDVTHLCSTTCPGAHNQKYVSEYGKVFHMECGKRHGTMPFKEEKQSTYRDCVDGCAKIPKCSSVDWSTRSEMCYYLTHSGAAPLRAPGYHSAYSFGCTRACGPSGCASCKGDCGCGDLGERVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUR7</accession>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_130024</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742110">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
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        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </feature>
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        <location>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149859.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="598" mass="65681" checksum="2E55469C40B1B312" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVA3</accession>
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        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_172250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
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        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="11"/>
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        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
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        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
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    </feature>
    <feature type="repeat" description="WD" evidence="6">
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            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="719"/>
        </location>
    </feature>
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        <location>
            <begin position="822"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="959" mass="106887" checksum="1EEE6E9A028797CA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVN9</accession>
    <name>A0A5N6TVN9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_116888</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVN9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1148"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="159"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1187"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1187"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8150131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1230" mass="133361" checksum="4BB385917B390F50" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVU6</accession>
    <name>A0A5N6TVU6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein translocase SEC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_154353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVU6"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7842" checksum="CE243391CAD80CAF" modified="2020-04-22" version="1">MSDTFQELADIPKDFVREGTLFIRRCTKPDKREFIKISQAVGMGFLIMGAIGYFIKLIHIPVNNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWM6</accession>
    <name>A0A5N6TWM6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWM6"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF6">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="274" mass="30841" checksum="C905A2825789E96E" modified="2020-04-22" version="1">MEPILYAHEIGEGLPILIIHGWQLEGKADEVDFEPIFSKTPGLRRIYVDLPGMGRTPANNIKNLDDIYDRLVQFIDSRLGTSRFLLIGSSCGGYLARAIAQKYNGQVDGLLLRVPLTEPEDSKRDLDPFKPVLTNEELISNIPPKDKELLGDVLVQTPAYVNALKTKFEDVYLPAEKASDSDALDPIRGDPRRYRLSISLDAKFFAPTLIVCGRQDGSVGYRDSLRLLELYPRSTYVVLDRGMHGLPIDEHGVFGALVRDWVVRVEEWRHRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWR2</accession>
    <name>A0A5N6TWR2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hybrid NRPS/PKS enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_139560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="5"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="941"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2385"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3633"/>
            <end position="3713"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="941"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2479"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2533"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2482"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2548"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4038" mass="441084" checksum="4026378E4EC4064A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWW2</accession>
    <name>A0A5N6TWW2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein dml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_153585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWW2"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="119"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="57212" checksum="9BEF5C99633285A4" modified="2020-04-22" version="1">MHEIVTLQLGQRANYAATHFWNLQESYFTYNEEDQSLVDHDVHFRPGVGADGAETFTPRTVIYDLKGAFGTLRKYNALYELTEDANLGQGLWDGKEIIQRQPAILQSDYQKSLDEGLPAPSLSSETVRYWSDYNRLFYHPRSIVQLNDYELNSNIMPFEDWTIGEELFNDLDKEHDLLDRDVRPFAEECDQLRAIQLFTSSDDAWGGFTAKYIDRLRDEYGKKAIWVWAIEGGSKVPRQAQLKRDMNKARSIYNISPQASLYTPIIDPPSRIPSNIHLDARSQWHTSALISSAMESVTLPTRLRPFHDFEASLAGDDGTHKIYELQSTVIPENDEHSPSGTRQSIDETEASEGGKPKAQAEFEIDFSYDGQGSGTSHIFNQLQVWRGVEIPDSEGAPSGRDLGLVRKERFYNTTAMFQRFHAPLSFPILDSYPSGMFSGAKEKKINILAALTASSRTADKIKLMERVAGRIISVDEREMVVNGLGEIREQYETGWMSDSDFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX66</accession>
    <name>A0A5N6TX66_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX66"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024965964" evidence="1">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="180" mass="20127" checksum="A1AC6A7C0E06B13D" modified="2020-04-22" version="1">MHFPIQKVLTTLIAAAALCAATLTNEQTPWKEVLHSFKNANPTDFFHLGDDGVLRHFTRTGIVLDYAQLSPQQISQSLADSSSRYTAEENEHLARVFQNIDGRNVKGSALLNPPAHIYPTPFLSNRETSDALEDGSLLNLALNPRQECPHKRCTDKTDCTKYANCTKCYVKDLFRTGECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX78</accession>
    <name>A0A5N6TX78_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX78"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="233" mass="26805" checksum="A9539DD75631B67A" modified="2020-04-22" version="1">MAVRIVSMTEQDIPDAVECVQTAFADDPYFHWLFDSSEYNIHRNAASLAAHFQYGLNCNTPMYVAKVPISDKHPNPVVGVSWWYAPQPSSKPVPWSVWAQDWLLSFRQLLFNVRFGGRGGLNLERYYLWKAMQKKTHDAVWTDPRGYYFCNVLAVNSEMRGMGLGRKLVEVVTRQADREGLSCYLESSKGLPNLIIYEKLGFESVKEIDCVDGKDACRLYCMIRRPKEKFPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYA7</accession>
    <name>A0A5N6TYA7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYA7"/>
    <dbReference type="OrthoDB" id="2415075at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062501" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="12953" checksum="89D102D66C7C6715" modified="2020-04-22" version="1">MQFFTHLIIPFTALTVAAVPWRGDRNKAVCFGFKETCDKPTGQCCPGLKCDLDNYECTSALREFVAGPLSHAIGLTANAALDIPAILKSLHVFPTKASTGFLTNGVSKARCSGIGLACYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYH7</accession>
    <name>A0A5N6TYH7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_171460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYH7"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="197"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="650" mass="73029" checksum="5052BBA4EC0F709F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYQ5</accession>
    <name>A0A5N6TYQ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_98682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYQ5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="204" mass="23302" checksum="E8330F7A9CFECB32" modified="2020-04-22" version="1">MSTYEVEHNTTDPSNTPTNRRRPDLSTFFSTLSEITPDTDRSRPHAVPVPRDISAAFYSLAEAFNVMRRDGSAAEQGTDANPELLTEMIQSLLREAETPPREVEGVSEEFCDVLDRVPRASLKPDQTCPICNNPFLEDQYPLVVRLPCHATHMFDLECVRPWLRLRGTCPLDRVDFAKQEREKAEARRKVADDDEEEEWDGMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ91</accession>
    <name>A0A5N6TZ91_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF11">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2001" mass="225075" checksum="0513EB5B93BB9A82" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZA3</accession>
    <name>A0A5N6TZA3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_171455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZA3"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="527"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="857" mass="95461" checksum="817EE2978FCEFA15" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZT8</accession>
    <name>A0A5N6TZT8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_152068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZT8"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="139" mass="15711" checksum="C7C5E182E9E4B633" modified="2020-04-22" version="1">MSAKVPRNFRLLEELEKGEKGLGAEACSYGLADGEDMMMSNWNGTILGPPHSVHENRIYSVQIHCGADYPDNPPEIQFISRVNLPCVDARSGKIDPTKLPCLAQWKRDYTMETILLEIRRYMALPQHKKLPQPPEGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZU4</accession>
    <name>A0A5N6TZU4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZU4"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="266"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="488" mass="56588" checksum="2DD4C881E7EB4D54" modified="2020-04-22" version="1">MADGLLKAEKDFSKDADKLIPEAEQTAKTDVQRAIDSLLGLEKQARQASDLPTTSRLLITIVTISKNSGDWGLLNDQVLLLSKKHGQLKQAVTKMVQVVMGFLDETPNMDVKLSVIQTLRTVTEGKIFVEVERARVTRILSNIKKSQGDLNAAADILCELQVETFGSMTRREKTEFILEQVALCIERGDWTQATILSRKINKRYFNRKPKKSPEEIEKLKKQAEEREKTRAPDEAPMEVDDDVTDLKLRYYEQQIILSNHEYKYLEVCKHYREVLDTESVENNPEQLRAVLARIVFYIILSQYDNEQSDLLHRIQQDSRLSTIPVESRLLKFFTIHELMRWPAIAQQFGPHLCNTDVFSHEPSQSIDDQPHKRWQDLRKRVIEHNVRVVAKYYTRIQMGRLTQLLDLTEEETEKYISELVTSKTIYAKIDRPARLVNFAKPRDADDVLNEWSSDMKNLLGLLERIDHLITKEEMMARILPTREKGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0N7</accession>
    <name>A0A5N6U0N7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_151481</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0N7"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
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    </evidence>
    <sequence length="1014" mass="112224" checksum="3B8622DEF5E12D05" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">IBT 18842</strain>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAE8152487.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="76" mass="8676" checksum="2B77958B2E322A5A" modified="2020-04-22" version="1">MAAGAFRGVISFFIFFGCFYILDVLCMCWGFWSSTIYVLLLRPCVILTFVSNTTQGLAYLLDRIQKSHTKNINIIL</sequence>
</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Salamov A."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="452" mass="51009" checksum="E3551DAAADE1043E" modified="2020-04-22" version="1">MDTHEIQPSPRYLFRQPLALQWFESGKLVKRHEEERQAGRFELFLDLLYVAILANFAETLAEDISGAKLVKYILIFAPSWHVWSDLRELMNSFYNDDLLQRVLILWVMSVLVMYGNNAPLVDEDISAMRATVGSYMVARISGSAAHLLYSFASYHHRAQQRLWVTLTLVSLCIYIPLYFESISVRSKIAVAAVGICAEEFSWVFCFSPAAKKMLKAKYTTAVNIAHEVDRYAAFYIVVLGEYLYQIVVGSPAAVGFNLGLLHAVWTLVIAFCLNWMYVHNDGALKSTHPFRYSVYTAFSWATLHLPLSASLLASGHVAAASAAEDRFRDPERWLLCGSLGAGLYCLYALALLSEDKDAPGTLMLPKHLRMIMRPIIGLIIILLGLARDLNITSIMSIIMALIVFCLIWENITSLHCGAGIWERWENTTYPEQRTFGNGHRYVEMTLLSVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1M6</accession>
    <name>A0A5N6U1M6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_170208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1M6"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024926568" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="18"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="429"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="551" mass="60681" checksum="F6D5EE34E885472C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1U2</accession>
    <name>A0A5N6U1U2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1U2"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024796206" description="Lactonase, 7-bladed beta-propeller-domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="39522" checksum="76177387A2827656" modified="2020-04-22" version="1">MHPTLVSILALPIGQALATKHNLFSGFFSGSQLYGLQFDDEAATLSLTKNITTSISASDGSKWIAIDDRHKTIYVTAGSSYLSYSINTDLTLTQTSNITIPETCNNLNYIAPSSSAPYTVFGAPYSTGCAGQAISVTETGALDAILANITYDSNAGVHGLALSADNKFIYSADDKGNAIWVHSYDNTTVKEVQHISAPSDASPRHIAVHPQGRYAYVVFESANEIGVYSRDAETGMLSFTNTTYPLIPSGFTNGSAYWSDEVAFSVNTESAPKYLYASSRSRSASSPGYVAAFSLTETGAIREQLVLSETTGSGGAANSVSPAVFSEEYFAITDSESDFVEVWKLSAEEKAVGVVAHLDLDNGPANVVWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1X7</accession>
    <name>A0A5N6U1X7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_137676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1X7"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="511"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="616" mass="66174" checksum="5B8355BD0581057C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U274</accession>
    <name>A0A5N6U274_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_127720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U274"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="51"/>
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        </location>
    </feature>
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            <end position="133"/>
        </location>
    </feature>
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            <end position="379"/>
        </location>
    </feature>
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            <end position="72"/>
        </location>
    </feature>
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            <end position="82"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="409" mass="43763" checksum="8090BB42E128EA6B" modified="2020-04-22" version="1">MVSGDRKLRAACDRCHELKNRCTRTGGLESRCDRCERLDIDCVYNNTARLGRPRVSRPMPENQKVDLSDSHSHSRHSKRRAIQRGPTTVSLPINHDPAYTATVASAHNRPGCAGPKSGRDSGPAPGGHDNLEPVPGLLPPILLSEVIPGDNLNWDLGIHGHPHQRYNPVENPGYQFKAVSDFSDSGLGVSEQGTVFTTRITGADKLLWLQSRLGNMLKCAIESPTEQQPAVDKVLSVCKELLELILVPDSRLSSNYSTAGNHGTEIGSPSFAPGSVNAGHPDRCHGLVATLYAYALQLLDLAVDNLKAHAGNLALISFGSFNLASQPAMSTSVGAYMVSSMVHQLRDAVHHLIPEYQQQKGPPPAHGSVPSGSDSGAAPANSVMQTAVNMVSQKEASVLEKSAQIIVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2F7</accession>
    <name>A0A5N6U2F7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_170019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2F7"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="284" mass="33088" checksum="301B0C0AF3138584" modified="2020-04-22" version="1">MTLTPKTDPQGAKHPEPILCSEKDHEIAEYEHGYKFRLHDGRVMPPFIGLERYKMTRSLPLRNTDICFVSWPRPGSTWLSYILVLLTGAEGKSLRDCYHWLESGWLYERGEEEIREAKDPRIFVSHMPYDMALGGDPSQTPCRYIYIARNPKDSWSGWYSGSWDHWLNMFMNGKCHRGDWNEKNILFLQYEDLLKDTRTGIKNIAQFLDIKLSDDALDAITAKASFSQMKGDKFTGMSDVKEAGQFYRKGKIGSWREQFTVAQNDTFDKLYKDRMSNTGLEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2N5</accession>
    <name>A0A5N6U2N5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_137517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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    </dbReference>
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            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="274" mass="31002" checksum="99E7AD9589C54B55" modified="2020-04-22" version="1">MESAFGKHLSSPTFTFTVGANKKEFIVHSSALAGLSQSLNTLMNGQMTEARTGHVDWPDVDEDTFARLCEFAYCRNYTPPSFSLIEHESPLPRTPEPINEEEKHRKPDSKRASNQTSHLRKRRVISTEYLHEEFKTSLVVPSPQVSDSEYIFAPPKITGPWEDFTLVFLGQARLYVLADKYGIEPLRRLILSKLHRTLDSFTLYDTGVSGIVEFVRFVYLNTPCYGNKVDALRDLAARYVVSVLDNIGEAGCFLGLLEEGGPFVSDFWRIAWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2R9</accession>
    <name>A0A5N6U2R9_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_150391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2R9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="81" mass="9386" checksum="CBCB4245AC18D5F5" modified="2020-04-22" version="1">MFQHHRLRLSLPEARARSQSGSLHPEKLQSGRPDLYVFHKTLPTQTPSMIPLTRTPQTSRAKDCHLPMCRSRQPNHHPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U370</accession>
    <name>A0A5N6U370_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_137153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U370"/>
    <dbReference type="OrthoDB" id="5422293at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="179" mass="21163" checksum="84985A29398D962C" modified="2020-04-22" version="1">MVGNVELEDAKLEHMDDLRSIPLWRARDTPERSLYRMYEAMISGVYEALGPETEYFWYQRKWSLQNISDPHDSDPVRYAILACLVEELVMAFNWRLSLGLRRDRHHQIRESEKDPHIPFTPLTRPPWTTCVRPVSREDLDRFPPEYVSVVGELVLERDGSNKTFARRNIITNVGWLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U371</accession>
    <name>A0A5N6U371_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_47886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U371"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="277" mass="29893" checksum="B7851FD76A9D12B0" modified="2020-04-22" version="1">MISTFQFAVVICTGSYHTPLPYQAMMDHLAARGIESHCPQRPSCDLKNLNVGDVNNPDFSREPPAGGYPPAAADAAVVGDVLDRLIDEGKSVVLVGHSSGGWVAAEAAKPERQVQNRALIGKPGGVVGIFLYGAFIIPAGESVTTFFAKAGTSNDTSHWLKFHENGLVTPLDTHLHLFSDVDEETGKKWGATLTAEAFMTSPLTHDPWSALPCAYVVMERDAILPPAYQEGMIAAQSQTSGRTFKVYRAPYGHEPNVSWPEGLAEKIEEFGREVLAQ</sequence>
</entry>
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    <accession>A0A5N6U3A9</accession>
    <name>A0A5N6U3A9_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 90-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_137313</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3A9"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="186"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="458" mass="52074" checksum="713BAC3B737B0DCA" modified="2020-04-22" version="1">MHRSWNSWCFLRRTIFAAAIGTCGVFIYLIWFGMNSDRDNVPPLLTQLIPAGHCTCQSSTSFQCADCLTCLASPPPSEQAHLAPWSYRYGRDDQNLGLSQSQCQAAFPGLFQDIHRGVEYWKSRGGISSDDLNTVPFQDGMARAIISNGDLYVVATRAKGDDHRRKILGTLGSIHRALSASSNRTSHPTIEFIFSIEDRVDDIDAVGHPVWVLSRKASEESVILMPDFGYWSWAKSNIGPYGQVVQTIMAAESNLSFADKEKKLVWRGKLSFAPKLRRALLDVARGKPWSDVRELDWSKKANFLSMEDHCRYMFIGHVEGRAYSASLKYRQACRSVVVAHKLQYIQHHHYLLVSSGPEQNYVEVERDFSDLPRRMDELLKNPDKADRIADNSVKTFRERYLTPAAEACYWRALWEGWAEISANATRDVERPPGDRGLRYESFVLLDSNDMFMYSFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3L2</accession>
    <name>A0A5N6U3L2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_169567</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3L2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="376"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8153019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="92725" checksum="0C41AFD000B07EF6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4F3</accession>
    <name>A0A5N6U4F3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4F3"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="368" mass="43248" checksum="94B458DB31C79F68" modified="2020-04-22" version="1">MASKDEDDLFDPPQEIADAELYDYIPKNFLLYMKNTQTEWRLGKVQSEKYRNHYQRHYGETGDICSVCVATQTEGPSVGMKAVVKIKVQVQRWTRAFPDDDEILLTDEIERELDNLTRLTEGGCTATPRLIDSNMVRQDNGYLNPGGYIVVLLMEKLPGMNLLGFANFSLEKRNQVRIAFGRAMSYIVDLEDTIYSDTAQCFRAYRDWKESGLSRPERGEEYYNPMMPGRKEKLDDSGETLSALGARKVDSDVFYHFRSEEWISRMTEKLGDVQEFYRFNIRHLDTNRRNVLWDEQNDRVYIVDLEDAIYWKEHRRFWAYRDWEEWGLSGPERGEEYYDPMMPGLKEKLDDSDKTLYALAARTKHVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U509</accession>
    <name>A0A5N6U509_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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            <strain evidence="1 2">IBT 18842</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">IBT 18842</strain>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U619"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="262" mass="29264" checksum="C3565DDFEE5DE7DF" modified="2020-04-22" version="1">MSRTPSERRQSYPASDSQWGKDKAFMFNSDLWRGLRWWERTTPNRPHSQSMKAPVGIPYRAPAMTRTKSWELPRGATVIDLTKPTPPTSPRHGEEKQKQKRYHDLDGAVVIDDDLSPNTTSRASQTPTEFPDDPTAEPSEPHGLPSVSDGPALPELPELDRLVIQAYPELEPLLEHGVLHSNGRCPNPVCSRSAFLSLLIPELQQIYREEVFNGSMREIIELTAQASYDTWLKVIDETGVDPLTIPISPVESVSGTSEETGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6H5</accession>
    <name>A0A5N6U6H5_ASPAV</name>
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        <submittedName>
            <fullName evidence="11">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_148163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8154253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6H5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000283">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="58957" checksum="0F2FC49B047A8DDE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6R6</accession>
    <name>A0A5N6U6R6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="45425" checksum="E0FDD62689ED4EE7" modified="2020-04-22" version="1">METSALETEKLLSSYDDWSDRELPSSTDIPLTPEGGSSMNINSGNTSLLSTVVHYLLSIFIWAPVRFLIYYFPPLDAVLPVPPAVSQSVSQEYQLKMKFLSSLLLLLASVDAINAHPTASDQFTGELEVASPNPSGLALRDLQGRARTCTRLNGFISRITSTKAQVAFVTFGPDAAKYICRAITHGDSTCDDWATGIRYSLLLVFALVHKDGAEPAVRGDSPARRSIGGSYLEIASSALGESGLQFASIEADENLPRVEKRSSDEPDLVERFLIRGLHHAEMGPDPTNIWVNHYSNGDNTLQIVPEDDQQDGNSTITKRWDKPGFKIAYTTRNKAPLNENQALQMAKHISYKWRTLAIGNDISDFIGFVETGHTANFYFRIIPEHKGYGLNYESVDICGGMADDTVDRHTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7T1</accession>
    <name>A0A5N6U7T1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_103272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7T1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="223"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="705" mass="79246" checksum="336CA77117C0FCE8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Y8</accession>
    <name>A0A5N6U7Y8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_135634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2438"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="940"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8154714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2514" mass="278508" checksum="AF680955CEB1EA51" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U977</accession>
    <name>A0A5N6U977_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore complex Sim4 subunit Fta1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_146637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U977"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30255" checksum="8A2D2487E352EB94" modified="2020-04-22" version="1">MEPVVEPRDRYNLRKSLTRLERDITALEEAGTLTLDEDILKQYRVKALPLSLDGTESLAPKFFSAFVPKDIPEPTQEFVGREYNTSRITLTSEYGRLIGIYLQSYIRKLMLDFPEIRQIWSSRQIGDYDFGNLYRMFEPEFGTLLILHVAKASKPHIKCIMHNDIRVDDSHLLCGELLTVVRIMLGQLKQKGFVNDMLAPVLLLSLNQHHPRAIEAYFDGQQLTVRRTDAYDFRSLNTAGFKTFARWFLGSPVGDTSNRAVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9H0</accession>
    <name>A0A5N6U9H0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_146966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9H0"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="38820" checksum="041316071A7750AB" modified="2020-04-22" version="1">MLIGLCGGICSGKHAIAEYLEQHQGFQLLELKRKDFPKITDEPEDVRWLQGSEDTSKEGNRPSPLVFETVGSLLDFATKRWQGRWVTTDIWESATIDRFLQRPFFLLINVDAPISLRWKRFAERCGRRQLEPPSLEKFVLWNDRHLYDKTIGYASLTDRAQVRLFNSTSSLEELHAALKTLDLADEERLRPNWDQYFMQLASLAAQRSNCMKRRVGCVLVRERRVISTGYNGTPRHLTNCNEGGCPRCNRGEGGGVGLSTCLCLHAEENALLEAGRERIREGAILYCDTCPCLTCTVKIAQVGISEVVYSQGYNMDQDSAAILEAAGIRLRQFSPPQNGLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9H8</accession>
    <name>A0A5N6U9H8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_146406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9H8"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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    </evidence>
    <sequence length="895" mass="96936" checksum="BDA75E692E751A48" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        </source>
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</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742606">
        <property type="protein sequence ID" value="KAE8144265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
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        <property type="entry name" value="G-gamma"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAE8144265.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="90" mass="10298" checksum="B93479DDFF7C4866" modified="2020-04-22" version="1">MPTYELRSGGDVKNKKQSVADLKYRRLTELNARLKEDLDRPRVKVSEAAMSLINYCNNTRDFMVPSVWGQVDKRDDPYAPQQQGGCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDJ0</accession>
    <name>A0A5N6TDJ0_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_145677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF152">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="165"/>
        </location>
    </feature>
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        <location>
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            <end position="195"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="213" mass="23308" checksum="6AF97D98E6821BD7" modified="2020-04-22" version="1" fragment="single">DLTCGLLSTFQYSILTSARSIFNPRFHLTTALVSGLFYLAPGAGFLIGSIVGGKLSDRTVKKYIARRGFRLPQDRLNSGLVTLFGVLPVAALIYGWTLQEGKGGMVVPIIAAFFAGWGLMGSFNCLNTYVAEAIPHKRSEVISGKYIIQYIFSAGSSALVVPIINAIGVGWTFTICVIFSIIGGFLVMVTSRWALEMQRWAERTFRIHEKPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDN5</accession>
    <name>A0A5N6TDN5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate/malic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_166712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742505">
        <property type="protein sequence ID" value="KAE8144488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDN5"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="477" mass="53146" checksum="1D4E09663333123F" modified="2020-04-22" version="1">MDIELPRHKRRPGDDGYRTPTIEDAEDYFAAHRKDNLLYPLPGIRVRQAHSSALKTLHDSSYPKPEGDDVPNVEDSTATQGECEYSTARLSWKRRIRHITWAYFTLTMATGGISNVLYTIPYRFRGLQTIGVIFLVLNIVLYLTIWGLLITRFYFYPYTFKASFLHPTESLFVPASLVSFGTILINVSQYGPDNTGHWLAHGVGILFWIDACIAVVFSAGIYLLLWSTQTFTIAQMTPIWIFPAYPMLIIGPHAGILSSKLEASRALPIIIGGTTIQGIGFLVSLMVYSAFIYRLMSQKLPRENVRPGMFVSVGPSAFTVAGIVNMAANAKACFPENFMGNGPLAAEVLIVVVNFAALWLWGLAIFFFFIATFAHWSTIGPGRMVFSMGWFSFIFPNTALITATFAIGQAFSSKPILIIGCAMVIPLILMYIFVCFMMIRAVALRHILWPQKGEDKDEGGFDISQVKPETPGDDNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDU2</accession>
    <name>A0A5N6TDU2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THO complex subunit 1 transcription elongation factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_95890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742534">
        <property type="protein sequence ID" value="KAE8144410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDU2"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="664" mass="74915" checksum="723F3CF101933AED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE25</accession>
    <name>A0A5N6TE25_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_95987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742535">
        <property type="protein sequence ID" value="KAE8144409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE25"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="513" mass="58811" checksum="712C6CA3EA9B06DF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEP2</accession>
    <name>A0A5N6TEP2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="9">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="9">MTA phosphorylase</shortName>
            <shortName evidence="9">MTAP</shortName>
            <shortName evidence="9">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_134324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="9"/>
    <dbReference type="EMBL" id="ML742427">
        <property type="protein sequence ID" value="KAE8144838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEP2"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
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    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="5 9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="190"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="581"/>
            <end position="582"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="614"/>
            <end position="615"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="740"/>
            <end position="742"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="9">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="9">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="823" mass="89596" checksum="D321586F0FD13BBA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TES9</accession>
    <name>A0A5N6TES9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_165901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742422">
        <property type="protein sequence ID" value="KAE8144875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="93"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="482" mass="52324" checksum="8A5CCC30542DC065" modified="2020-04-22" version="1">MANRILESPCYLAEGQNDEEKRPDKNANGMFLPPEEVLQDKESDANHHRLNGLSRMSTHVSNVGVLASRTLSVVRTRESGKDLGPPPDGGFLAWSQVALGHLVIFNTWGYINSFGVFQTYYAETLGHPPSDISWVGSIQIFLLFFIGTFSGRATDAGYFKAILTLGAVLELFCIFMTSLSTNYWQLFLSQGIGQGIGCGLMFCPTIALIPTYFSTKRSIAMGIVASGSATGGLVFPAVVMRLLPQIGYEWTMRILGFISLATLLPCLIFLKQRLPPRQSGPLVEWTAFKEPSYALFTIGMFLNFWGLYVGFFYVGSFARDVIDVSQTTSIDVLLVMNGVGLLGRLIPNLMADWYTGPMNLLIPCSLATGVVAYCWATVNNQNGMYAFSAFYGLAAAGIQSLFPATLSTFMTDLKTSGVRMGMVLSVVAIAALIGSPIAGALVERDGGQYLYAQMFMGSAIIAGAIILSAARVVKLGFTWQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFE9</accession>
    <name>A0A5N6TFE9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_84807</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="ML742428">
        <property type="protein sequence ID" value="KAE8144831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFE9"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="685"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8144831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119207" checksum="4623FEAEEA586289" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFY6</accession>
    <name>A0A5N6TFY6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_165008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742363">
        <property type="protein sequence ID" value="KAE8145294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFY6"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="308" mass="34448" checksum="B6BA537CCD9EE37F" modified="2020-04-22" version="1">MPPRLQLLPLQWQRPLSKPLSTASPLSFLLPQLQQQSRNAHILASLSDNPGAYNKRIRRGRGPASGKGKTSGRGHKGQKQHGKVPARFNGGQTPDIIVHGERGFNNVHSIELATVNLDRIQEWIDQGRIDPTRPITIRELAQSRCIHQTKEGVKLLGRNSESVLKQPIHVVISRASSSAIAAIEAAGGSVTTRFYTKSAIARIMRREMHPFVSLAWTDESGSEALNKAEGAEHLTESNIMKAMGFQYRLPDPTKRKDIEYYRDPAHRGYLSHLLKPMEGPSLFFRSPVERKTTAGVKKEKVLPENRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG95</accession>
    <name>A0A5N6TG95_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_133871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742357">
        <property type="protein sequence ID" value="KAE8145337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG95"/>
    <dbReference type="OrthoDB" id="5427091at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18710" checksum="E3C278F1A6A365DD" modified="2020-04-22" version="1">MALVPANMSFPLEANDPLFYLCWRRQSCGWCLQGDAPCSWCAVTSTCVPNPSRFPILAPLHSSKICPLGSKERWELRAVPFGCNVSTFSFLTAIVAVLGTLVAIALGYHLVRVGRRMRQSLGHGKLGWGRLDWGRMRRGFFRHRAPEDVEGNHVRETGTERTPLLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGK2</accession>
    <name>A0A5N6TGK2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_164511</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="ML742338">
        <property type="protein sequence ID" value="KAE8145514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGK2"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8145514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="496" mass="54723" checksum="DE1796CAE5CDF90D" modified="2020-04-22" version="1">MIPRAAAPTSSSLAHLSTRSLRVQGQAARTFATVQDNAPPVRHHGGLQDQDRIFTNLYGHHGADLKSSMKYGDWYRTKDIVLKGHDWLISELKASGLRGRGGAGFPSGLKYSFMNFKDWDKDPRPRYLVVNADEGEPGTCKDREIMRKDPQKLIEGCLVVGRAMNANAAYIYIRGEFYHEATVLQRAINEAYEAGLIGKNACGTGYDFDVYIHRGMGAYICGEETSLIESIEGKAGKPRLKPPFPAAVGLFGCPSTVTNVETVAVTPTIMRRGASWFSSFGRERNAGTKLFCISGHVNNPCTVEEEMSIPLRELIERHCGGVRGGWDNLLAIIPGGSSTPVIPKSVCDEQLMDFDALKDSQTGLGTAAVVVMDKSTDIVRAISRLSTFYKHESCGQCTPCREGSKWTMQMMQRMETGQAREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEKRIQEHAQQLGQAPYAGGWHPNSRAEGKLISPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGX1</accession>
    <name>A0A5N6TGX1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_164240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742327">
        <property type="protein sequence ID" value="KAE8145628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGX1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="116" mass="13031" checksum="7DAD61AB925673C1" modified="2020-04-22" version="1">MSFQKPEKDFGEGPKVHKIRITLTSRKVAALEKVCSELIDRARSKSLHVKGPVRLPTKTLNISTRKTPNGEGSKTWDKYEMRIHKRLIDLLAPTETVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH10</accession>
    <name>A0A5N6TH10_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_66106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742323">
        <property type="protein sequence ID" value="KAE8145668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH10"/>
    <dbReference type="OrthoDB" id="5409998at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="319" mass="34040" checksum="1EC056A90DD5D32B" modified="2020-04-22" version="1">MSASDYSNPDSLGVLAAMVNQTLIDTGRFFQAKASTQSRAHLKRSIPAAHEQFQCALDNLSEQIFIAKAFLEKDYEAITAQKAALQPVEDVVMDQPEPIQEPEASPQLEVVDTKPQEGKPSTRPTVQSPVDVSTNQKGTTGDSMQEKEPAVPTASGSDQPQTGPADINFDAVLNDSGGANDFDLNLDFGDDDLGNETFLSGSNFGNTAAGGAPNQQKRSDQTNNMTSDITGPENNNNTPTGGDLFDLELKKTGVFDTQHGADEGQLGNGTEDIMAPGESSFDDLFMDNENFGGGEVGDSNMLEGDGLMNINELDDSWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH16</accession>
    <name>A0A5N6TH16_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_66921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742330">
        <property type="protein sequence ID" value="KAE8145597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH16"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="11487" checksum="38D0EDA821FB21E4" modified="2020-04-22" version="1">MAFIPSIVWGGINMSERCCSILSVLSLVTTAYIMKYIPLRHLGPNGKRPMQGLKFVAYVHKYAIPVNTAICGFLLFVYMLTAPMESSGNNQPAAYLVPGGRSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THE3</accession>
    <name>A0A5N6THE3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_62699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="ML742317">
        <property type="protein sequence ID" value="KAE8145742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THE3"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8145742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="230" mass="25237" checksum="7123EEB8831BF536" modified="2020-04-22" version="1">MSSKPASRGPKGLTKVYLLAYNAASFALWATCTTRGLDLLASNPNDIPAVFKDVFWPLLAGTQTLAVLEILHSLLGIVRAPVLTTAMQVASRLLLVWGVMFLFHDKGDGAGIVGGTDAVAQVGDYAFMGCLSAWGITECIRYGFFALQVLGTGVPAWLSWLRYNTFYILYPLGITSECVMVVKALNPAAEFNPLYRWFLIVVLGIYVPGSYILYTHMISQRKKAMKKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THL9</accession>
    <name>A0A5N6THL9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_133403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742305">
        <property type="protein sequence ID" value="KAE8145874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THL9"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="5">
        <location>
            <begin position="314"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="702" mass="77854" checksum="44A1FA589C509C09" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIM9</accession>
    <name>A0A5N6TIM9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742298">
        <property type="protein sequence ID" value="KAE8145959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIM9"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="39446" checksum="EF0D22AEC6772141" modified="2020-04-22" version="1">MAASESSRYLARSLPRAFAPSARPQSICLRRNLSDQASSKAAPADLEELESTGSLHATPSAPDAVKSFDPISKSRGRKKQLPRSRYQFRSPKYDRGPLHPHQPPKPSDPSSRLYVPGPFSLPRVEQTYQSTVTSDILTLCYVHNPPGFKPPPKAPRLRSWDDSSPYHKNRPLRGPRGGDVLRLLRKPINFNNIPKLERITIHSYVKKAAQDNSSWLHVAGMAVQAISNARVETFKSKTSVATWSIAPGRDSVAVKAELRGEDMLHFFGKLVDVVMPRIKDWEGVKGTSGDSSGNITFGLEPENVALFPEIEVNYDMYPPKMIPGCHITIHTSAKTDKDARLLLSALGIPFYGKMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIU8</accession>
    <name>A0A5N6TIU8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742292">
        <property type="protein sequence ID" value="KAE8146031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIU8"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="437" mass="50764" checksum="EFB0EAF031ACEF21" modified="2020-04-22" version="1">MEFPYMRAFIALFLYRYLRLVVNVVSFWTFKPILPPENPRLTAQDVTVILPTLEGCGDELVETIRTILESHPYELLLVTIEANRKKAENMLSLMPASKSRIRLFTVTHPNKRRQMTRAIPEVRTPITIFADDDVSWPSTVLPWILAPFEKDERYGGVVTCQRLRRAVAPTFSQRIWGFLGALYLERRNFDCAATTHVDGGLPCMSGRTVAYRTDILQDEGFTYAFTNEEWWFGRYQLNADDDNFITRWMVSHGWETFMQYHPEAEVLTTLEDNPKFLKQCARWSRSNWRSNLTSMFHEKHIWYRQPWSAYAVHLTTLSPPALLGDLLLVLLCHKATTSWGTNSHAFAMQALGVWMLVSKFIKLLGHYVRYPVDILLLPVSILFGYFHGGIKMYAVMTLNVTTWGSRDGADDYDAERMKKRTDSNRPKLPYYPKFITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJB5</accession>
    <name>A0A5N6TJB5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742260">
        <property type="protein sequence ID" value="KAE8146464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJB5"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="328" mass="36625" checksum="FA04BD82792BE9D3" modified="2020-04-22" version="1">MASKLLVVVGATGNQGGSVIKSFLDDPNWRIRGLTRNTTSESAAALQAQGVEVVKADLDGVASLETAFQGATAIFSVTDFWSAYFRMAQDTSARHEQPANKRAYQYELQQGKNVFDAAAKVTTLERFIFSSLSDAGKWSKGKYTNVLHFEAKAHAAEYGEKTYPELWKKTSLYQAGWYMANFLGEWLSPKKSDTGVYQFITGVRGDAHMPMIAAEEDTGPAVKALVACPPGKNLIAYREWMTPDEFARVWSRVLGLPAEFVTLPADQSIEGVPEDLKQEFLDNWAYFNEFGYEGRDDPSLVHPHQLEVKFEVPTVENWIKKQDWSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJU0</accession>
    <name>A0A5N6TJU0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_47247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742250">
        <property type="protein sequence ID" value="KAE8146634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJU0"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="408"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="858" mass="94325" checksum="8BC32BE22DF474FE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKL9</accession>
    <name>A0A5N6TKL9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DOPA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_169529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742237">
        <property type="protein sequence ID" value="KAE8146896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKL9"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="202" mass="22948" checksum="25714F3EDE7CA1A1" modified="2020-04-22" version="1">MKHTTTYNLDPSQYSYASPLDGWNERSNSGGDATGGGISEAYDRFLWPVSNGRPDGAQLPGFHVHIYFSPNDSFQTKFASELWQRVRSEFPELHLFPISTAPEGPHSAGMFEVHIFTPAQFGAFVSWLVIHRGPLSAFLHPNTDDELRDHIQRYTWLGPEVPLNMDIFKLRPSCELLDSRDNSVVRVWVEADKVKTERIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKX5</accession>
    <name>A0A5N6TKX5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_143424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742245">
        <property type="protein sequence ID" value="KAE8146741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKX5"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="559" mass="59946" checksum="DA3DFD32E6A50108" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKY1</accession>
    <name>A0A5N6TKY1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_41855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8147006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKY1"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="121" mass="13966" checksum="377FC2B6526648F4" modified="2020-04-22" version="1">MGFFTGFFSGFALTTTALYLSVQVHRSIRLEQRNTIREQSQALNSLASPVGAYDRRLAPKDLPPTQELSEPLRPTMKDLLKHHWNQEIEKLARKAYDIHWEDARNTAAEGWKTVTRLVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL83</accession>
    <name>A0A5N6TL83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_41151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL83"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="54117" checksum="A034910252C2DA14" modified="2020-04-22" version="1">MRSTLRLDVGLVTCLAAFSGLADAFWRLPCRGRAGLARLDPLMDPGKAASHVHTIHGPDSFAMVADMDSLRDSSCTSCAVKQDRSAYWTPAVYFLHDNGTSELVDQVGGMLAYYLLYGTDIQAFPDNFRMLAGDTYQRNFTWPIPDPPKSEWTGSQASQASLRQKAIGFNCLNYNKAAEASLGRHYLPDKAYLDEHCTDGVRFEIMFPSCWDGKNVDSDDHMSHVAYPSQVMDGTCPEGYENRIVSLFYETIWDTYAFKGKSGEFVIANGDPTGYGYHADFIHGWQDGVLDKAIKKCTNLSGRIEDCDVFDIQTESDQRQCKFDLPRILKNEDLYSHEGGIPNDIVIESGPAYASPVRYNTATASATATQSAGASVSVSVGLSIDLGGLGNIGGHVAVDQSTTASSATTPTWTPTPTTSYVEGEVTQAVIYVEREVIVLVDSQGNPVQTVTGGLETVSTATTTVSGTVSTVVTTPTEAPAKRDHVHHARHAHGHGHAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLJ7</accession>
    <name>A0A5N6TLJ7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_43056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742232">
        <property type="protein sequence ID" value="KAE8146989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLJ7"/>
    <dbReference type="OrthoDB" id="3922101at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46325" checksum="51ABCF8A96931366" modified="2020-04-22" version="1">METGPVQLDIPHIHRIFQGYPGESSSPYLTGALWIASPGIGHQRCPQVRICLVQDVTIPPRDAKPNGDKNLAPILRRLRGRSSEKAGTYRNRETLVQCDLWDTPDRATNDSGQTGLRYHFSIPVPHNIPGSTATLAGRVSYTIQATVTTTSGTTVTTTPLCVMRCTIPGHTRPVDYVRNYPGTALETALTITPAESPRLRSKASYALKLVARHTIAPGDRPKEVKHVVVRDIKWTVEETVRVVQGSTDRADQATCTHQYKRQLCHGKRKGPWIPGKTVLKDEQDAMNKDGRIEIPFDISIPRRSKTADDLSPFTETPQKVDVSPDQCTASIREKPTIAVEHQVILDIMTGEDTYDQQTGVLLRRKPLWKSFQASFPLPVRQVAAVEEIPPSLYAEDTTLPPYDDGSANPPSYETLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM07</accession>
    <name>A0A5N6TM07_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Wings apart-like protein regulation of heterochromatin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742211">
        <property type="protein sequence ID" value="KAE8147358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM07"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="2">
        <location>
            <begin position="358"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="821" mass="90718" checksum="713F9027EBF84638" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN35</accession>
    <name>A0A5N6TN35_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_32361</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN35"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025099331" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="15">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="57095" checksum="B93D38B609BEF015" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNE0</accession>
    <name>A0A5N6TNE0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742186">
        <property type="protein sequence ID" value="KAE8147893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNE0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="31775" checksum="5088BD895CE4696A" modified="2020-04-22" version="1">MESITKSDWDRTASEYSELPRDGPLLIPCMRLLESMHSTLSFGSATTIIDIGGGPGTAVNLLIDNYGYEIPPQAQVIATDYSPAMVKATQSRIETEKTSDKKNATCWGQVQAMTVDAQDLSAFPSNSASHLMGSLVYFMLPDPPKGLQEAFRVLGAGGVFACTSWSQVQWMEFLNQAVQEVRRATGSELHSVDMRSVLKHWGDTAGVKEELESAGFRHVRSEYIEFDWHVEDPRAFALTICKSPNPGTQMVLGDLSDDKLDCVIEHYERILKEHGNVCKGVAVLGIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNL0</accession>
    <name>A0A5N6TNL0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_131734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNL0"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="299" mass="33244" checksum="70BC8F7D8292D6CA" modified="2020-04-22" version="1">MANRGYDVVVDVDAEGDLGHTDLQEDLEFHPSNFENDQRNAKAQQDSAPFLGGGTSRGRDRSPGGTPSKHKWWSIHYYSQFFDVDTNEVLRRCVAAVYPRSNFLDVLEGNADLYGPFWIATTVVVILFLTGTISQWLSNNDAEHFAYDFTLLSGAAGLVYGYTFILPIALWGALRWFGSSTADLIECWALYGYSNLVWIGVALVSWSPLTALNWALVGVGFGWTVFFLLRNLYPVLSATDAKASKILLVLVVLLHAGFAIAIKILFFAHGSPVSKKNKDDDKGQDDNHDDDHKRRMLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNM1</accession>
    <name>A0A5N6TNM1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urb2/Npa2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_159748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742194">
        <property type="protein sequence ID" value="KAE8147711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1482" mass="165734" checksum="2097B94D3F5436CE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP37</accession>
    <name>A0A5N6TP37_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_23178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP37"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="13"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8148060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="52540" checksum="635FF44068481CFE" modified="2020-04-22" version="1">MASSEPSHIRIFTLNCWGLKFIAKHRHERLSEIGRQLALADPAPEIVGLQECWTQQDYESIRQQTRHILPYGKFYFGGIMGAGLAILSRWPIEESTMYGYPLNGRPTAFFRGDWFVGKGVACARIRFGPGAGDVAEVFCTHLHAPYEREPNDSYLCHRTAQAWEIAKLMRGAAERGHLVIGLGDFNMLPSSFAHQLIRAHSPVQDAWQVIHPDSSIGAAVDPAEKKRGKPVPTAEFNLQVNGATCDGKFNTWRWSKEDQKRLDKGEDVAVDKDAPCPKGKRLDYIFVGDGGYPPLFPAPRWSVESVQLGMTQRHPTLRCSLSDHFSVEAVITRAEVDETEDNRLQQSITPNAALAPDTYDRIIDMIHTYVRRERSQRRWRMAHFILSVFVSIGCFIGVWWTGDHLPYVAFILVLVSTLSFGAGILDGLIGGMFVSSELRALKEFEWEVRNAKELMERNTEPGKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPK3</accession>
    <name>A0A5N6TPK3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_21083</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="ML742170">
        <property type="protein sequence ID" value="KAE8148210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPK3"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="20">
        <location>
            <begin position="99"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="19">
        <location>
            <begin position="264"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="21">
        <location>
            <begin position="678"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="441"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8148210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="880" mass="99068" checksum="698CC7C97AE4367C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPL3</accession>
    <name>A0A5N6TPL3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_20629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742169">
        <property type="protein sequence ID" value="KAE8148220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPL3"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="180"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="434" mass="48500" checksum="874D4385286DE1A9" modified="2020-04-22" version="1">MAKNKRLRSTPTNRGNGSQPKKARKMRTFSKLSTVIHSGPSTSKPSDTGSGNKINKNTIHQRQNIPFDKRDRILLIGEGDFSFARSLVVQHRCKNILATCYDSKDDLYSKYPQAESNVRTVLSGVPSCKKHRDILGNSVMSEETERKEQREANSSGNHGHRTKEGMLSSYTSMPEHLCRPKVMFSVDARKLGRTPGSGKDIRVGYPRRDQRLPAWQQAKKNCDSPFPKGGPWDVICFNFPHVGGLSTDVNRQVRANQELLVAFFKASVPLLSSPLANGSDDIEEEYRWDTSDGSDTDSDKDSVSPDSRNMMGPNKSSSRNGPGQILVTLFEGEPYTLWNIRDLARHAGLKVVTSFRFPWDAYQGYSHARTLGEIQGKHGGRGGWKGEQREARMYVFELNEESRITSTQNPQSSKNAVGTSDKKRPRASDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ02</accession>
    <name>A0A5N6TQ02_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="7">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_131213</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="7"/>
    <dbReference type="EMBL" id="ML742160">
        <property type="protein sequence ID" value="KAE8148436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ02"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="15">
        <location>
            <begin position="999"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8148436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122053" checksum="19ACE94C5F16B9CA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQD4</accession>
    <name>A0A5N6TQD4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742159">
        <property type="protein sequence ID" value="KAE8148484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQD4"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="44597" checksum="559F93AC287C1D6C" modified="2020-04-22" version="1">MISTPTTFFTPHRKTNSFVQGGGIIGSCSAYYLTRHPSFDPSRHSVTLIEATEIAGGASGKAGGLLAQWAYPSNIVPLSYKLHADLAEEHNGKERWGYREVNCGQLIARGRPLNEKTKSDEGSGSSVSLQKRSAAALSKLKKARVPNDLDWLEPEGLRGYENMSDPGETAQVHPYLFTTSIAKLAEEKGAKITLGSVTNIDYSDDAVKSVTYDSKETGESHTIPATDVVIAAGPWTRSVLPEAPIAATRAHSVVIRPTRPVSGYTLFTNIEIPANFDPSKPSRPTVATPEIYARPDDTVYCCGDGDHTVPLPKTSAEVEVDEERCQEIINQVGSVSDELRDGQITARQACYLPNVTAVRGGPLVGHAGTKGLYLAAGHTCWGIQNAPGTGKLISEFVFDGGAKSAKIGSLDPRNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQH2</accession>
    <name>A0A5N6TQH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_15894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742154">
        <property type="protein sequence ID" value="KAE8148585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQH2"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113379" checksum="722C793F7BC47773" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR79</accession>
    <name>A0A5N6TR79_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_11932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742146">
        <property type="protein sequence ID" value="KAE8148797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR79"/>
    <dbReference type="OrthoDB" id="4505626at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024849999" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="26684" checksum="34589E6A6E3E575D" modified="2020-04-22" version="1">MNPQTLHYILFLLLNSATYTQGWSLTYQTNTSTPYITTSEQPQPCTKISQAKGHKFRFVPNDSPYSFYVWANDNCSGPYSGFTPPAVWEKVASTDLRSYLVGSLDLSATGTGTSATGGVSATGTVSATGASSVTDGDGGSGSGLSSGAIAGVVVGVVAGVLLLAGAFWLGRRHRRTDGSTQVPQQFGGSGYILPGTPIAGSEGHPAYGNNMKAYEHELPGYASGRHVFAELPGDSAVVEMSDSSRVRELEGDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRC8</accession>
    <name>A0A5N6TRC8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRC8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF26">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="70028" checksum="3A72298A657166A5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRR2</accession>
    <name>A0A5N6TRR2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_157393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRR2"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="389" mass="43449" checksum="77DB31CC4C23E8E9" modified="2020-04-22" version="1">MALDNYYRNKIESMKLEIIQGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMSTKKVLVKVHPEGKYVVDIADGVDISKLNVGKRVALLSDSYKLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIDSAGSGDSEVQRTMLELLNQLDGFEPTKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRSMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMYALRERRVHVTQEDFDLATAKILNKHDDKEVAVSKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS50</accession>
    <name>A0A5N6TS50_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_6513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742133">
        <property type="protein sequence ID" value="KAE8149130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS50"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="62" mass="7143" checksum="0F4D5829B9DEAFC6" modified="2020-04-22" version="1">MQVVSTRNAILPKNENEKLIESVKKVKKQKERFIPGKFTPKERNRKGNKPPQESHIYPGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSJ4</accession>
    <name>A0A5N6TSJ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSJ4"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="445"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="722"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1016" mass="118873" checksum="F87F4D791B7A37E8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT54</accession>
    <name>A0A5N6TT54_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">BDV25DRAFT_172742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT54"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="177" mass="19938" checksum="2FC47443F91F058D" modified="2020-04-22" version="1">MFSFFKRDTPQPDQQQQQQQQQPKPAQPQESEIKLINPQTKYKLLFGGLTFFAFSFWMTRRALNKRYLASIPPFYTSSLYHKPKVNGGADAFEALNLATLNVLSLGMAGTGGVMCALDVNGIEDMRAFVRKGFYGDGGGLSEADEELERSVEEWVGNVLGEKFGVELKREKELSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUJ1</accession>
    <name>A0A5N6TUJ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_119062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUJ1"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="219" mass="24204" checksum="FAD3C81ABD8368FB" modified="2020-04-22" version="1">MDHHAMHHSGMDMDHGHGDMDMGGKCNMNMLFTWSSKDLCIIFRQWRVSGPWSLIVSLVVIVLLTAGYEGVRQLTRRYEAACAKRLNAFSAPVVGGKCRIFSLNSFLLLCDFVTRGVLLGDNETTGEAAPANVPSSQNVHSYDVRSPLLVGRDNRRVVEQRGKLIMAALYAIQVFYSFFIMLLFMTYNGLVMIAVAVGAFVGYLVFGDNTPASKSVACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUM8</accession>
    <name>A0A5N6TUM8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUM8"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1600.10:FF:000006">
        <property type="entry name" value="SIR2 family histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="124901" checksum="2AD3B2CB7E6850EB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVG0</accession>
    <name>A0A5N6TVG0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radical SAM enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_172274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVG0"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024992449" evidence="10">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="27"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="322" mass="36655" checksum="94B8235C9541C22E" modified="2020-04-22" version="1">MWLFNISILLLALWAGLKLRHRKTTTTKKPISVNYHFTRQCNKTCVFCFHTATTSHVEKIPAAKKGLSLLAKAGMKKINFAGGEPFIAPFFLGTMINFCKEELKLESVSIVTNGSLVTEKFLAKHGHNIDILAVSCDSFNEETNIAIGRGKGEQVKKLYEIRDLCRKYGIKFKINTVVCRYNHLEDMNAYIERLAPFRWKCFQVLIVEGENDSAQTLRDARKVLITDAEYESFCERHKHHRSFVPESNRLMAKSYLILDEYMRFLDRTGRAPSGSILEVGVQNALDSVFWDEESFVDRGGVYDWSKDTSGCESGPSGKGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVJ1</accession>
    <name>A0A5N6TVJ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_172203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVJ1"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="59653" checksum="3380CF5FD44C7245" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVS4</accession>
    <name>A0A5N6TVS4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVS4"/>
    <dbReference type="OrthoDB" id="160054at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024949658" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="149" mass="15406" checksum="17D5F147FDEBA5B0" modified="2020-04-22" version="1">MVAIKSLAAAVVFGASLATATLEPASSNTQGKCPGTLNCDPAKTSTAIQAAECAYNTRTSETQTFAVFVTDHQYDSSNGAPYGTCKAYTCTAPTSSEMTDSDDDCWTFFWNDNGEDSGVGTSCIKSPDDGTCGCENSDGSFVYGGSNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW83</accession>
    <name>A0A5N6TW83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_154168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW83"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8150557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="600" mass="66908" checksum="CB1BD40C8FFC5CDE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWD8</accession>
    <name>A0A5N6TWD8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_153867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWD8"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000088">
        <property type="entry name" value="HLH DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="294" mass="32275" checksum="915361B92D406DB3" modified="2020-04-22" version="1">MSDPSMGAPDGNINNKRKRDSTDSTGPDAQRLNRSSNGSNGSMPGPDTQPNFGHSLGSYDPHGLSGGASELNIDQQILQHVGPQNGISDENALTAKAALAAHTPQNKYPPPPDATFDNNIAHGLTFSDEMGQAIGGAHGHNSTAAAVYAAREAQSMNQKPSVGSPEWHQIRKNNHKEVERRRREAINEGINQIARLVPNCDKNKGAILQRAIEYICQLHEEKKTMSERWEQNNMTTSHAINEISTQNSKLKVEVNRRGDIALKWLQRCRDAGLECDDYEESKELEPLEVDQGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWK6</accession>
    <name>A0A5N6TWK6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWK6"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="91" mass="10637" checksum="BA0B84F9EE049022" modified="2020-04-22" version="1" fragment="single">MKLRVLHIGDPIKYNHDVYARFSSEFEIIQPTAEEREREEFMRALKERRWGDFHAVFRPFWNTGGEMGRWDSELIPLLPKSVKVMASAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWW8</accession>
    <name>A0A5N6TWW8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease III homolog</fullName>
            <ecNumber evidence="15">3.2.2.-</ecNumber>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="15">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NTH1</name>
        <name evidence="18" type="ORF">BDV25DRAFT_105652</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWW8"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000027">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="189"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8150790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="46003" checksum="96C7485050B275A8" modified="2020-04-22" version="1">MRTSRASKQTEKVLQALSPPTRRQTRSASNLNAIRSFAYSGDANGLVESKASTSDDDDLSSLSSVDTVDIEDILEPPAKRQRSNVGSAPARRNGSRASAKVPDKTAEKSVKAEAVARKARRTPARKIKDESGSFKIEPPSNWETIYSTVKKMREANPTAPVDTMGCAELYWRGSSPQDRRFQTLIALMLSSQTKDTVTAVAMQRLHTELGDNGALPAKDTIIKQETDDTYLSPKPLKDSTLNLENILAVAPERLNSLIGTVGFHNNKTKYIKAAAVILRDQYNSDIPSTAEELMKLPGVGPKMAFLCMSAAWGKHEGIGVDVHVHRITNLWGWHKTKAPEETRKSLESWLPKDKWHEINKLLVGLGQTVCLPVSRKCGDCDLAGTSLCKSEIKGLVSTKKKTSPSPKDEGVGGVEVKIEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX11</accession>
    <name>A0A5N6TX11_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_129180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX11"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF6">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="450" mass="49949" checksum="31F4E86E5D864FA0" modified="2020-04-22" version="1">MGFRVVIIGAGPAGSVLANGLLRNNVEFCVYERDEESSKREGYLIRLGEDALRGFKACLSKSQIDTILGKFSQTDVSLSTAPAVYNSRFQLLVELDRLPGYPTGASINRVVLRDELMKPIKEAGKVQYNKTYSHYGITRRPDGSEKVLVYFDDGTTDECDVLIGADGSASKVNHQVGARNLVKITSHWGFHAKGKLPLDRVKQLPPKVLEAPIVVFSRGALFYFALYIPPSGKLPEKVKSIANGQYDESMASFYWSMHIPRHRIPYKSAADIPDRLQLCLDNMEGWAPELRMMATIGSTDEDASLYAGKLRGSDRLPPDWRSRCQGNSIEGHPRVWLIGDAVHTMLPNRGQGGNQALRDCSEILPELLKLNDQALAGQVPSTEDIRSACDRYETIMFPRAFDWVKTSGGTGAPDFDLDGMLGYMVLVFSTFALPVVIAFYRIGQFLTHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX32</accession>
    <name>A0A5N6TX32_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX32"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="680" mass="76739" checksum="939BADA0DBB7891E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX34</accession>
    <name>A0A5N6TX34_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_105764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX34"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000119">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
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</entry>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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    </dbReference>
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    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF24807"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAE8151020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="622" mass="67213" checksum="00AC550C904142D8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXP5</accession>
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            <fullName evidence="12">DNA ligase</fullName>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXP5"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="600"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8151143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="878" mass="96845" checksum="EE49DADD63C6C318" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYU9</accession>
    <name>A0A5N6TYU9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_152433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYU9"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="109"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="571" mass="63794" checksum="DD0AF3FBD32BF5BC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ29</accession>
    <name>A0A5N6TZ29_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ29"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="106" mass="11952" checksum="65484EA07F04429C" modified="2020-04-22" version="1">MLSSLPSSWVATIGLPLALRRMRGRCHVTMIPPFTVILKTKELFTNNSHSAGSTDSTVGKKRKIIWKQVRRKEGGRKAPTYAIAYDLIPRQRERGRSGGGTREIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ82</accession>
    <name>A0A5N6TZ82_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ82"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="24195" checksum="D2C56AA1797F8E4F" modified="2020-04-22" version="1">MSDRTCYFPAGNEAEGNVPCSGDKYTSCCGSGDLCLSNGLCMNINHQPYLLSRGGCTNQNWDQGCPEYCSKINPRGGTSIINLVFEDDTITYCCGTPVGTDNGTGTVCPDDQDAFTIADGTPLAGYAMLANVSSLSATNTSSGETGNCTATNTAEAGAAGAGSCHEAAVGAGVGVPLGLLALGAVAWAVFERMRAARMRSLGGGGVAEGAGYATVYTDPKPVAELEQGRTVHEMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZT2</accession>
    <name>A0A5N6TZT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_138508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742064">
        <property type="protein sequence ID" value="KAE8151794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZT2"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF141">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024994128" description="Rhodopsin domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="115"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="423" mass="46860" checksum="862318B293121690" modified="2020-04-22" version="1">MSPLREFFLVFVAFTGSATAADSSLSFNEQCANSCEQNILNDSTSTSNATVKSLCAIPIQLAWEECLFANCTVKESFTAKRSQAHQCNIPTHHGRPAADPALIVPLAIATLLVVARLASKCMHVGGGWWWDDYTIIVAYILAVFIFAMNASMIHHGFGKDIWTITPFDNITIILKRFYIYVLAYKAQISLAKISVCLFLLRIFRSPAFRYTAYTIIALNTAIAMTWVLVDALRCNPIHLAWTGWAKEEPGKCIDFIAATFANSFVNIAVDTVMVIMPIYEVIKLNLDSRRKLGVGVMFAMGLILTVVAILRVVVFYFNRWNKNPTVELQPINVWSVVECQIAVVCACLPAARALLLHFFPGMMGGSGRDSDARRATHTIASSVPKGRGKISQTVSYSVDYSRRPQDRASNSAIHLVELDQVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U037</accession>
    <name>A0A5N6U037_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U037"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="406"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="510" mass="57506" checksum="FFCA1DE69E2F86C8" modified="2020-04-22" version="1">MSSSGLDIAQLSDSEQSALETYTTVTGQEPAEAIPLLRRSQWNVQIAIAKFFDGEGPDPVEEARAGLNTPPPRSNRQTQNLMTEDLNARFSPAARATDLAPRVTTQSEDQPVYRPPFLLALLFTPFNILYRLFCGSFRLFGTLFPFLPRLFNTTASSALHGTRRNTNGRRPLGPKDTAARFIREFEEEYGSNSLSFLENGYNMALERAHRDLKFLLVILLAPEHDDTNGWVKDTLLSREVVDFVNDPQNDVIVWGGNVQDSEAYQVSNSLRCTKFPFAAAIVHTPNVSSSAMSVVARISGTTSPSEFVEKLRSAVAQHKEPLERIRATRAEQQASRSLREQQDSAYERSLAIDRERARQRREAEAARQREEQEAAERQAAAEKRVHDLQQWKRWRAQTISEEPGADIKDAVRVSIRLPSGERVIRKFAPEADIEELYAFVECYDVLQESPKPAGVEKPQGFEHCYWFRLVSPMPRMVYEVSTGGTIRDKIGRGGNLLVEPIDDESDEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0D4</accession>
    <name>A0A5N6U0D4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0D4"/>
    <dbReference type="OrthoDB" id="5382170at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025034224" evidence="1">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="422" mass="46812" checksum="F8F0EE94752CFA53" modified="2020-04-22" version="1">MGFVFIIYQVLLLLFGTVLGTSFGPDQYLEPFEFPKARRLAAANSPLDLKARTDLETVVLARKATFDFIHEPPEDGKEHEFAATAEVESQWPIFALERLDSDLNEVTCSDTQMQLFLNSLDRSKAIMQELEGISDFIIVTSHEGCDVEGERSIHKATNTAFDPERLVLSLDKAKCDWHDAFHSTQVSFSHRHLSRIQKRAYTFNKRQETDEPTTTKRVEGPTPDITIPTMSFSTTRLAPTATKALTQRYIDKKIFPPDFPAADLVIPQGVEVSCKNCTLQGYIEISKGSFNISGNGIKDAIAFFDHGSVDIVAKSLFSHIELGLDLSPSQALASLNMSLPTIPLTPFEIPGVVAFGPLIQPRFRLSVSLVEKIGFSYGFNLSVTLLGPTNIGYGTNVIRCLIIRPSKSTWTSLRTPLFRGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0G1</accession>
    <name>A0A5N6U0G1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_151576</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0G1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="ATPase_P-type_domA"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8152112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1006" mass="108818" checksum="A6DEE3242550CD4C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0L8</accession>
    <name>A0A5N6U0L8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8152132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="57"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="49853" checksum="19A89E3DCFF7E6EC" modified="2020-04-22" version="1">MTSGPFRIVDHVVECQHLREYPAATANDQEDELYLAVKQYIPLDNPDPQPGDVTILAAHANGFPKELYEPLWEELHARSRDNGFRIRSIWIADVAHQGQSSVLNEDLLGNDPSWFDHPRDLLHLVNVKRKEMPRPIIGIGHSMGGAHLAKLSLMHPRLIHSLVLMDPVIQRQTTQLDGHDMEKQKMTIAKTTQLSTHRRDLWPSRKAAAESFNRSPFYQAWDARVLDRWIKYGLRDLPTAIHQLPEASQDSEDTPVTLRTPLHQEVFTFSRPNYDGPPGKDVPVNRITHPDLDPNHVGSFPFYRPEPSRVFAELQYLRPSVLYIFAGKSDMCLSVMMADKMANTGVGVGGSGGEAAGRVRDVYLKDFGHLLAQEAPVECAEAASSWLGQELQRWREEDQAFQQQWSQKSKVEKLTIDPRWKEHVPAPVRVKKKSSESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0U2</accession>
    <name>A0A5N6U0U2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0U2"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="314" mass="36073" checksum="F60E178763C9FE41" modified="2020-04-22" version="1">MSLITSRALRLAFAILATLLFAIILWLPKDSIRNVHDITLPARHSRISVNWSRSAYVQYVTNTAYLCNSVMIFEALHRFGSKADRLMMYPSGFSLDGTSVESKLLRKAQGQYGVKLMPIQVQSKEDRDSTWAESYTKLLAFNQTQYDRVLSLDSDVTLLQPMDELFLLPPCPVAMPRAYWLNFDDRVLTSLLMLVQPSDFDALVIPHRPYSMLTGEFRSKRHADYLGNPLETWDPERAFEEAKLVHFSDWPVPKPWIQIPTSTMDEQKPTCDNNNQTAVEDCRARDIWLGLYSDFIKRRQNICGMAAEETANDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U143</accession>
    <name>A0A5N6U143_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_128086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U143"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="255"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="567" mass="62733" checksum="89CF9B2F5BA74798" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U173</accession>
    <name>A0A5N6U173_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-specific methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_70115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U173"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="3">
        <location>
            <begin position="39"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="344" mass="39514" checksum="45B84C7C1B73F3B4" modified="2020-04-22" version="1">MTVTAATTVVSPDEQSGTIIDIGTGTAHDTVLSQQKQMVQQRLLKKENGKRWLPTALIWGDENAHQLWWEASNLDEFYSIRDEVNLLKRWAQDIARQVPDHSVLFDLGCGDVTKVIPLLNELERSGKHVHYYALDISRKPLESVLAKLPTTYQVVKYTGLWGTFDNLRAWCGNIQEPKWFLSLGSIFGNDEFQIATNDLRKWVSVMRPQDRMLLGLDGCDDDEKVWRSYNDTKDCWHRMIRNGLELSNKVLGHEWYRPEDWEVIGVTQRRSPTLTHQWVARATRVVQCEPLGLYLSPGEEIITNEWYKYGPDGMQKQFDAVGFANVGQWKSPSGPVYQYLLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1A7</accession>
    <name>A0A5N6U1A7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BDV25DRAFT_137895</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1A7"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
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            <end position="130"/>
        </location>
    </feature>
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            <end position="422"/>
        </location>
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            <end position="880"/>
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        </location>
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            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
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            <begin position="243"/>
            <end position="253"/>
        </location>
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            <end position="275"/>
        </location>
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            <end position="356"/>
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    </feature>
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            <end position="389"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="820"/>
            <end position="853"/>
        </location>
    </feature>
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        </location>
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            <begin position="869"/>
            <end position="880"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="919" mass="101098" checksum="EAB8D74ACCC926E8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U267</accession>
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        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">BDV25DRAFT_150723</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0034515">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="877"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
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        <location>
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        <location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123998" checksum="BEFD2501572DDB8C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U315</accession>
    <name>A0A5N6U315_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_150394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000451">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000721">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
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    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="558" mass="61753" checksum="16ABCC662E356144" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3I1</accession>
    <name>A0A5N6U3I1_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_127607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="248" mass="28039" checksum="B449E02E312E7DDF" modified="2020-04-22" version="1">MSRSSLLQSRWAPGPDEVEVQKPASTRGPSLSAQDLSRFMKIVARLKWKLPFLAEGYRLATLPTASGVDVAQAEIMFKIDFFEYYALLERAIVHLLGVFGVRISGAPQTLRLRRQDRSPPVATHRYHANVLEALESESCPLHPVLGTGDVHEQLRQAKELRNRWKTADLSKEEQQTDASRWSRKEKRMPLASYDFENILTEIFNGLEEGCLLAQEHIARTEAGHGPGHAMDSEADWDFIVDAMDWEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3K3</accession>
    <name>A0A5N6U3K3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_137249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="12183" checksum="5290880E54B0DEFA" modified="2020-04-22" version="1">MDRTALAQKYRNASNAATYDKVVDDFDKADRDHDGNVTFQEYKNVAYDAGERYAPGEEGVIEKYWLLKDKNNDQKISLEEMLEFEFNPNEEEVARFFDELDAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Q3</accession>
    <name>A0A5N6U3Q3_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Thioesterase-like superfamily-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_127479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Q3"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
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            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31625" checksum="89FE9861C64948D1" modified="2020-04-22" version="1">MATFGDSWIPVIICVLIAAYKNLPFVWFIRFLRALTTRLFISPITKKELSPECLFAPAIHRTRSPLTECDYNIHKSNSTYFTDLDISRGNLSLLLFSQRLSFQPTPKTAVMILSGIQIVFRREIKPYQGYEVWSRVLSWDEKWIYIVSHFVKRGAFQPGKTLLQSSSSQGQTKQRSLKRDESPEKHVFASAVSRYVFKQGRKTFSPEQMLIECGLLPSEESMAGDEGVAMWNNIEARRKKDLEAAQLKLGWDAVHSTFDGDTTKILGRYTDLLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Q5</accession>
    <name>A0A5N6U3Q5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase G1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Q5"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
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        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="123" mass="12556" checksum="1775291AD9A266A6" modified="2020-04-22" version="1">MEFNFGDVIVASVESTSPSEGVTVIENLTTGKNFTTTASAPSSSATLTGTNAEWILEDLAVDGDGLTLVNFGEASFTGCVAKAGGKEYGLDGSALYAVQDSSSSSVQAVPSIVSDSELKVSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Y0</accession>
    <name>A0A5N6U3Y0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_136949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Y0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000263">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031592113" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="54"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="588" mass="65030" checksum="DBB1C677F10913BA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Z4</accession>
    <name>A0A5N6U3Z4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_149770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Z4"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="36702" checksum="EDF96C4A9D81F83C" modified="2020-04-22" version="1">MSLIQRTIRAIRGRFSREIRSEDLDSQRTEIFSILANLYKELETLKVEALESKHLEILRIHILPLDLTRTTELVIPRSLDPSAYFTPLSEEFIRQRPLDTTDPSTQRRLDGIAGILRPGYSCSEIEYWPLSSYSKAGVLVDRLVMEMSSRRLNCEEAMPRMTMITKWRWNTDFHLDLAFPYDAWHHSDDYDWSINFFYACSSHPTFPHIKVLMHHSDAKNPELILRAEVMAIAATMYSRLCTETLLEHLIVPVMLFTFAGCRVRILIGIHDGQKLRITMSEFIEYSEGSQDLWDLLTRYLGCGINNQLSTKKLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4J2</accession>
    <name>A0A5N6U4J2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_27931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4J2"/>
    <dbReference type="OrthoDB" id="2884623at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="205" mass="22942" checksum="C2DED0FD97FAE4B5" modified="2020-04-22" version="1">MSLWPIFITAPNATPKQINKALIELDDYEYGASSSWVVVHTSEPPITPTASIPPLAIPELTSTTNFFAGKAPQDVHAYVQDPATRSLFSDRDLTTYHWVAIDEKGLGEETCLLAQYEEGREPDADGEVREFKMCRIPWASAWSMFCNLDLANMDFEEWVEEDVGPVEEDFGAWKWVGPFSGGSVDEEAVSKRKDRLATAEKEGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4X4</accession>
    <name>A0A5N6U4X4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4X4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="233" mass="26688" checksum="2971FFBE919A5685" modified="2020-04-22" version="1">MNQCDEIYAIASQIDNLVQRSRARLSTSDLAKDISRRLDRFEEVERRMCDFKQLFEHQMSQLEWSIMVEIDRLKEDVGSLSKSVGGSSDTISSLQKGIGAPNGRSRRNARAIEGTNPRNIGRVGEISQPRDRSRSFPIDPSKFSFIKGSENGRNFYYKGCKISDDSEVVVFVNTKKKRDILDVYVNKSHFMELQGKTPIRVMPMQNIMSDEDLRNFLNGANTAWSEYSRKDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5G6</accession>
    <name>A0A5N6U5G6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_15089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5G6"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024905955" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="188"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="412" mass="44494" checksum="9A185FA4627DC7F3" modified="2020-04-22" version="1">MSFFTIATFLTATLLGTKPVEGATVADSCGSWDASSVVCINKYASVLPGQFSRAIPANLAGTDSFAATEVPSDTSFASIANATFIVYDSSVAEDILGSSPNLEVMFTTPMINHEAPIYVPDSGHLYVSPIAQADTELLLIDVNASPPTLEYFSAEPPLYAATGSAYSDGLIYYSTTGINDTTTDDFVTTGIYTFNPKTNETETLLNNYYGYYLNGADDIAIESNGDIWFTDDYYSWLDQTATVQPTLTPAIYRFRPSTGVVQVANTALSQPNGIRFSPDGKTLYVTDTGAANGPVDVSFDEIQYTWDSKGARTIYAFDVVQYSSNTSSIINGRPIYLANEWAPDGLQVAKNGYLVTAAGWSVDILDQYGILLVQIQVPFRVGSIAFAGEDMNELWLVGMGNIARVQWALQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U611</accession>
    <name>A0A5N6U611_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_148474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U611"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000024">
        <property type="entry name" value="Endosome-associated ubiquitin isopeptidase (AmsH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="367"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="546" mass="60740" checksum="A1D9A6BF8021C850" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U642</accession>
    <name>A0A5N6U642_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U642"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="154" mass="18486" checksum="3480B2C9904CD048" modified="2020-04-22" version="1">MSNISQIHEELFRNNETRRVVLKMRAQSLDLEDLRSSTYRVINDMFPDWENDNRVLFLAAEIWGDRAFMAIDINNHEYNFQTAHKTKIVFPVHVLWLHKRKGWILVRWPQEDKKLAERLAYLHNINGFAATPFLENHNFRVIHANPRDFSWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6B7</accession>
    <name>A0A5N6U6B7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_1664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6B7"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="291"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127108" checksum="9CCC2F69E91934A5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6L4</accession>
    <name>A0A5N6U6L4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6L4"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024908915" evidence="1">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="92" mass="9736" checksum="5BE5DE205AE67E95" modified="2020-04-22" version="1">MKPLTYLSLLLGISATALAALRPDATPDEVAAAEAECGSLGVMRIDPAELPEGISMSDVRMCADHPLGSRAIPDLGPGAFARLRRFIPSWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6L5</accession>
    <name>A0A5N6U6L5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6L5"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="36319" checksum="F210F387136B8285" modified="2020-04-22" version="1">MWNTVVPRILQPDFTWPRTIHYKISEVTPAVPRLPGKTTRKAWGLFHKALYYLSEYYCSWFHIHFDPHIVQLPFGLVMKWTDRTSLEEAAAMQMVEAAGIPVPKFLSCGEHPADPSNRKYSILMTRIPGIALENSFDPFQADTEEPWLYELRTCLHSMRQWRPPCPTSICSAIGTCLRGPRIPCHIMGPFANKEEFYEYLFSPASSHGFKSITAYKQALSCARKLEHHSHRVTFTHGDFKAHNIMVDDDGHLSGFIDWESAGWYPEYWEFTTAMRFGRSSWWYQAASWMGGDQYSDELASDIALNLLTVDSYIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7B6</accession>
    <name>A0A5N6U7B6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_115930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7B6"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025090293" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="377"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8154299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="532" mass="56907" checksum="576AD56906692461" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7D3</accession>
    <name>A0A5N6U7D3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7D3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="201" mass="21834" checksum="091EE93DFDBC0836" modified="2020-04-22" version="1">MWLVTDGRISLPDTLGIQSFRRLEAGLDWEQRSGRLTAYLTDRDESWYMRPHLALLGAIYNSHVEAKMVGGRRSAWVRGYIRVHGLPITVEVALPAVELFVASVPARRIAEVAENIYLTLISADINIDALKAVKSVGSTCLEVTTLGVERGEIILDGAIAGSVAILRGMVTSSLVKASGKSERAVSNAVSEGFQEVRDQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7D4</accession>
    <name>A0A5N6U7D4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7D4"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000028">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein (AFU_orthologue AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024942580" evidence="2">
        <location>
            <begin position="20"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="272"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="760" mass="83137" checksum="AAAD657358E00407" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Q0</accession>
    <name>A0A5N6U7Q0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_148296</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
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    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="168"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="36886" checksum="F13353288E3FCD2A" modified="2020-04-22" version="1">MTEEQPQVADEVPQFSFKKRSAKAKANFRKKPEAPPPASDSDSDFTSSDDGEGQRIKRRRKNAAVTASSASNAPRREIEEQPAKAAPAAPVSSNDATKQSNWYDELDEQNLLGKTRTKPASTTPSAPDGTYKGAANYQSFIQKNPDAPSKTFGPMKAPTNVRTITYMDYNPNVCKDYQKTGYCGFGDSCIYLHSRDVIKQGWELDKEWDDKTKGKKLDGTVVSRRGDKSNRDNEDDEDEELLESIPFACIICEKSYQNPIVTKCGHYFCESCALQRYRKSPSCAACGAGTGGVFNTAKKLSQLLEKKRERARKRREQAIADGEEVSSEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8B8</accession>
    <name>A0A5N6U8B8_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_147244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="57"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="148"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="887" mass="101377" checksum="ACDA524C5D1B723F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8D3</accession>
    <name>A0A5N6U8D3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Chovatia M."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="852" mass="93944" checksum="CFF6DFE78625E33C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Nybo J.L."/>
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                <person name="Haridas S."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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</entry>
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    <accession>A0A5N6U9A0</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chovatia M."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="281" mass="31013" checksum="1DCD7CE11A29D3ED" modified="2020-04-22" version="1">MCVLTRTHPQQLTPSCPAPCGIGGTLTPLFWASCESCYLDLTTSYHSPTLKCPAARASAKERTVIPIAPDSDHIYHKGEAHEIRAQSLTTIKFRGANSTPRVSIDDTYLMLFKDIWPIVLPALDSQLHDYWKFLTTKYEDTIDGCDMIRSEDLTVNLRIQQTLLEGFMSLSPICCDHVVSDGIRQQPITVAACSEQNNSRIFCASHSILPPVIGLPVAGRYLLSYVGVVRSSFFVIAVRIEAPQVSAQVPHGFCPHLTSDRSAMTCSCLAKPYKGFCTKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9S3</accession>
    <name>A0A5N6U9S3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9S3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="17729" checksum="E4742D57579B9780" modified="2020-04-22" version="1">MLIKIVEGCDLSVSMNRVIMLIKQIEKKVPMKALRSTQTPHKLKGDMLELVGLGILLSNIRSKSVNQQAADGAQAMLDVCAKQLENLAEDINALNEGSSLDTKQLNELFGTHRIRQAINCLWNEMDYLISTETEPSWTMIEEDQPEGDPLPPQMGHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCI7</accession>
    <name>A0A5N6TCI7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_167671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="ML743010">
        <property type="protein sequence ID" value="KAE8144095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCI7"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="166"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="475" mass="51870" checksum="0F92240F0313312E" modified="2020-04-22" version="1">MSSPSSAGKRKRSASQHLPPNITNTDILQPSSRDASGEDGDDSTGPNTPLVKHKKQAPIDVTSSGNVPPSKRARKSSMGGEQTNGAATEDPSALNKEDPGEPSETTVASSDIESRSKGRPGLHITTTDVPTPEDEAMMMPPEIAGLHDPVGYHTNPPPVGRPVRVYADGVFDLFHVGHMRQLEQAKKAFSDVHLMVGVTGDDETHSRKGLTVLSGAERAESVRHCKWVDEVIPNCPWIVTPEFIDEHKIDYVAHDDLPYGAAEGDDIYAPIKAQGRFLVTQRTEGVSTTGIITRIVRDYDQYISRQFKRGASRQELNVSWLKKNELEIKRHVAEIRDNIRYNWTTTGQELGRELRQLWQNSRPGSPAPSARNSIDMGSTRGNIVSPTAGAAKTHLSRVEAMGRPESPMGNGRNEDFATGYSLGLIGGVRAWMRSRQSLVGSRAPSPTSEEEHESEQERSNGHAETAKSHTTTVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCY9</accession>
    <name>A0A5N6TCY9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_167299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742624">
        <property type="protein sequence ID" value="KAE8144245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCY9"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144245.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="584" mass="64195" checksum="5DB0AE2595956CA1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD81</accession>
    <name>A0A5N6TD81_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_167273</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="996"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144252.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120635" checksum="EC8F14EF291BE3F5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDB0</accession>
    <name>A0A5N6TDB0_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_167283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="99" mass="11343" checksum="87CC51D959FD76F4" modified="2020-04-22" version="1" fragment="single">MKLITANFLTCAVKGCKSSPASFPLHFKDAELELQELDFQPEFIQNVIPRIDWEGLQMMASELGFPRIMEKKPEGDGLKDEQILKELHRLLLETQIKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDN9</accession>
    <name>A0A5N6TDN9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_95931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742535">
        <property type="protein sequence ID" value="KAE8144407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3918840at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1320"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1522" mass="167785" checksum="AFB3C4A29768AF1E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEC5</accession>
    <name>A0A5N6TEC5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_166183</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742447">
        <property type="protein sequence ID" value="KAE8144724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEC5"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8144724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="448" mass="49905" checksum="0D3444227B9D6FD6" modified="2020-04-22" version="1">MREIVHLQTGQCGNQIGTAFWQTISGEHGLDSSGVYNGTSDLELERMNVYFNEVGNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSSAGNNWAKGHYTEGAELVDSVVDVVRREAESCDCLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVAPSPKVSDTVVEPYNATLSVHQLVEHADETFCIDNEALYDICMRTLKLSSPSYGDLNHLVSAVMSGITVSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAISVPELTQQMFDARNMMAAANFHSGRFLTCSTIFRGKVSMKEVEDQMRNMQTRNSNYFVEWIPNNIQTAVCSMPPKGLKMSSTFIGNSTSIQELFQRIGNQFSSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQEATVSDGEGYGEGEYEEEAVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEI5</accession>
    <name>A0A5N6TEI5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 complex, subunit Ies4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742449">
        <property type="protein sequence ID" value="KAE8144716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEI5"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="263" mass="27349" checksum="A6E733DC4C30473E" modified="2020-04-22" version="1">MPATPTTNGRSSRSGNSSKGVVILKLSPELLGRFISPSLEAKDKKKNGTKTEEPAIDSPVKESSPASSSVEAPVPPSDNASDAASTPAAGTSAADTPRRKALQGPKPGAKRGVNQMSESTPKPRGKPGPKKKPRLDDGAPEPVKVTASHRLGPKANTGAINAGLRALDRSGTPCRKWERKALQLKSFTGIQWQLPSWRTPRPQKPEENGESKVSVLETGDSDSKANQSASGVPSEKSNSGDGDLTPVPPNIVEASSPAIAMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEM7</accession>
    <name>A0A5N6TEM7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_166546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="ML742486">
        <property type="protein sequence ID" value="KAE8144561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEM7"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="127"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="230" mass="25390" checksum="B8A1F52BBD223F64" modified="2020-04-22" version="1">MAATLLRTSTRTALRAGASATPKAAGVAGLTFARGKATLPDLSYDYGELEPYISGKIMELHHKNHHQTYVNSYNTAIEQLQEAVHKQDISTQISLKPLINFHGGGHINHTLFWENLAPKSQGGGEPPSGALAKAIESSFGSLEEFQNKMNTALAGIQGSGWAWLVKDKQTGSVGIKTYANQDPVIGQFQPLLGIDAWEHAYYLQYQNRKAEYFKAIWDVINWKTVEKRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF66</accession>
    <name>A0A5N6TF66_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_165569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742401">
        <property type="protein sequence ID" value="KAE8145013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF66"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="386" mass="44034" checksum="BCC00E697E2F866B" modified="2020-04-22" version="1">METDNSNLQPWAIATTTSVTVLAFVTVCLRLLSRYERKQKLWWDDWMIIFSMCWNLVVVGFIFAMIKEGMGLHATAIKSDDPTKNVVMIAKYLVVAEVLYVFNLVWTKISILLMYYRIFHFAYFKTWAYIIGTFVIAWVICITFLFIFICVPVQKLWYPYLPGHCINQVGTWIANAISTILTDLIILCLPIPQVWKLQLRLSEKLAVLFAFGLGSFVVFASAYRFSVLFTYSAVDSSYTLAPTVGWTAIEMSAGIVSACLPTLRPALRLGARLLGLRGRLPALFRSTEGKTNKTSHATQDVSRTVDSTTTMLKAERPTRHSFYHLPDDLDEQPAQNDLFRPDYDHAKTYTNVKGPRILKEDGRFSVDEIPLNGIRVDREFTQTSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFD8</accession>
    <name>A0A5N6TFD8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine phosphatase family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_145237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742429">
        <property type="protein sequence ID" value="KAE8144821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFD8"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14957" checksum="594BE47A688784F1" modified="2020-04-22" version="1">MAQAYNLPEILATDIRNEIPSQIVHSIISQPPFIVIPGLFNIRDISNDSTYLRCGYAYRSGVLSSISDQGKSALHDLNITTVFDLRRLDERTKSPAPVIDGVEIIWEPYTRDPGKIDFRDFEQGDQAASGFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFT7</accession>
    <name>A0A5N6TFT7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_165120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742369">
        <property type="protein sequence ID" value="KAE8145235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFT7"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="441"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="822" mass="94388" checksum="C8447AE902C4C17F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGU7</accession>
    <name>A0A5N6TGU7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_164260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="ML742329">
        <property type="protein sequence ID" value="KAE8145604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGU7"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000009">
        <property type="entry name" value="Para-aminobenzoate synthase PabaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="306"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="518"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="825" mass="91229" checksum="FBE6176FE021D4A9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH45</accession>
    <name>A0A5N6TH45_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_144448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742324">
        <property type="protein sequence ID" value="KAE8145652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH45"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="127"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="632" mass="71537" checksum="E366CB2C305704A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THC1</accession>
    <name>A0A5N6THC1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_133604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742325">
        <property type="protein sequence ID" value="KAE8145650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THC1"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="491" mass="56375" checksum="5B2318616DEF93C9" modified="2020-04-22" version="1">MDPIAEPRRNKKQRAVLSCIPCHFQKIKCNHVRPCSACCVRGRQSKCEYTVTLEDRWFIEQAHLLRRLQQRRNFLEQRILALLPDSQNIPVYITSPPLNPSKSRGKRQNRSPKTSRKNSPSSSCQEAVLPKQEPDDKLLCLDQLQSHVTNNSNMQPLRLTHTERSIQSLVEVLSSNIEGNRTTPLWLEQAIQLRASSPLLCAAIEATSFILTGKLQSDPKSMHAGLVRYTCALRLAGTALRDPTERLRDEVFVAITLFGMIEMYEGNSTDGLRNHQQGGLDLLYLRTPSRHCKDVGHSIYVDMRLQWIISSILHRRTFLTNEEWKTIPWSETGSRIDKHDLFDIAADIPGLWRELDRLYYGSQTSSPCGSPESFGSSVEEQAEQLAQRLQEWRESQNPDTLPTEALFTIRDDFPVFETQDPQGIHKPRDLVYPNAESCATTISYWSFYLAIARGTPLTWQYEFACNICRSMRFCVQNFPFALAYLKRKRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THD8</accession>
    <name>A0A5N6THD8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_69437</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="ML742338">
        <property type="protein sequence ID" value="KAE8145511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THD8"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="550"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8145511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="670" mass="74467" checksum="93238EF47BBF7CB2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THK5</accession>
    <name>A0A5N6THK5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative succinyl-CoA synthetase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_133466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742311">
        <property type="protein sequence ID" value="KAE8145812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THK5"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000017">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="682" mass="73745" checksum="740AEB5104DC784A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THM5</accession>
    <name>A0A5N6THM5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_66970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742330">
        <property type="protein sequence ID" value="KAE8145601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THM5"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="1">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="28264" checksum="394601E7D883ADDA" modified="2020-04-22" version="1">MLSKQSISIISRWLPQPPRLVQHVSPPSLTRAKVSMPHPSATFRRAFTFPTGQSSFLPSRANPRVNNIRILRTRQSSGFRRFFNTSRPMSSPQSDQTGSLSQRLKALSREYGWSALWVYLLLSAMDFPICFAAVRFLGAEKIGHYEHAVIETCRHALGTIFPNMQEEFQSQETGGLKVKDETGEISEGQAVEGAQKRADEGASLWTQVALAYAIHKSLIFIRVPLTAGITPKVVRVLRQWGWDIVKGRPKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THZ7</accession>
    <name>A0A5N6THZ7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742319">
        <property type="protein sequence ID" value="KAE8145721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THZ7"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="2">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="181" mass="20073" checksum="57729CD1DD22225E" modified="2020-04-22" version="1" fragment="single">MAEEIVIDKNAFFNRLSSFYTAWKADKRSSHTVFGGVGSIVIVMGRTDEANTFQKNNAMHFWLLGYEFPATLMVFTPEVMYVVTTAKKAKHLEPLKGGKIPVEILITSKDPEEKTKAFEKCLEVIRNAGKKVGVLPKDTAAGPFVEDWKRAYATTSEDLEEVDISAAISASAFSVKDTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI42</accession>
    <name>A0A5N6TI42_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chord-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Larsen T.O."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51401"/>
        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Dilute_dom"/>
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        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
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        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
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    </feature>
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            <end position="25"/>
        </location>
    </feature>
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        <location>
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            <end position="541"/>
        </location>
    </feature>
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        <location>
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            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="842" mass="94986" checksum="C9B15FA2F1FFE4DD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIC1</accession>
    <name>A0A5N6TIC1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose/galactose isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_163193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8146095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17305" checksum="F013219CE51E546A" modified="2020-04-22" version="1">MSTDIKPLRIVVACDEAGQPYKETLKAALEKNPLVESVQDVGVNSTSDKTAYPHLAVAGAKLIKEGNADRGLFICGTGLGVAIAANKVPGIRAVTAHDSFSVERSILSNDAHVLCFGQRVIGIELAKKLANEWVTYRFDPKSSSAAKVQAISDYETEFAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJA9</accession>
    <name>A0A5N6TJA9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_50007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742261">
        <property type="protein sequence ID" value="KAE8146458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJA9"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="300"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="622"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8146458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1170" mass="127656" checksum="FE8A931CDD707994" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJN8</accession>
    <name>A0A5N6TJN8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_143660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742259">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJN8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="44077" checksum="2E2CDB269BE76E1B" modified="2020-04-22" version="1">MGHKIASKASLPSHCVSTDGFETVRPSEVLEEERFERFKQGQYYPANIGDVLTSRYQIIGKLGLGVTSTVWLARDLDGHRYVTLKIYTRDEDNQEEFQIYEQLNQGSSWHPGHAHIRKALDIFTIPSSGGYHPCLVQDPMWESFRDLLFRNPNHRFTEDLLKSGLMQIFLALDYLDTECKFVHTDIKSDNILQGIEDKSILESFTQAELKSPSPRKIVFGRAILSDFGSAVRGNERRNHDAQPNVYRSPEVMLKTDWGYPVDIWNVGVMVWGLFEGRHLFYGNDPDGKGYSTRAHLAEVMGFLGPPPLDMLQRGKRSPEFFTSGGKWKQDIETFPTGVSLELSEEFLDGKNKEMFIAFMRGMLQWRPEDRKTAKELLQDPWTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJP5</accession>
    <name>A0A5N6TJP5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_162706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742270">
        <property type="protein sequence ID" value="KAE8146329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJP5"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29006" checksum="4BADEB9BCB127746" modified="2020-04-22" version="1">MGGRIKNALLDEATHAREVAQDVAKSGAYLYPLKGIIYFAYHKSLWRPFLSRAGQTMSVGLSVTSAMFFFTYVPQVAIMAFTSGPLAPFSAALLVLTESSTITNFLSRSFVLDDVLIDTFDGTLVARGHESLVAEGRQLQPASNDAIARLGKKIKKPLDKMRPRALLRALILLPLNLIPVVGTVLYAYAQGKKLGPVAHERYFQLKGWNDKEKEEWVKKFRGGYTGLGIASFVLEMVPFASIAFAFTNSVGAALWAADLEKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJR8</accession>
    <name>A0A5N6TJR8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJR8"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05323">
        <property type="entry name" value="ADH_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32056" checksum="E3D3092237C6F157" modified="2020-04-22" version="1">MGVHHDRVAIVTGATSGIGIDIAKDLYHRGWKVACIGRRAQPGHALVKELGANSQFFQADVGNYQSQAAAFRRVFQLWGRIDALCANAGVVDQSSIYNFTRRDAASDDLPPEPDLSTTDINYKGVIYGTVLATHFMRQNKPQRGGKIIVTGSIGGIFPHRSYPEYCGTKAAVNQFIRGVAPLLRAKENIFINCVLPGIVSTPIVPPEMIAAVTLECLTPVKTILDAYQVFLQDESGRTGELLECSADKMISYPMQEMGNGHVTQRAVTVWEPLFRQMHGEDSGLPDAIRQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJU1</accession>
    <name>A0A5N6TJU1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_143534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742252">
        <property type="protein sequence ID" value="KAE8146607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJU1"/>
    <dbReference type="OrthoDB" id="4442531at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="36420" checksum="C4124CDE22300BDE" modified="2020-04-22" version="1">MATSDSFDALRTLLEAALKTPKEQVLSGHIPLPPKLLLTSTGEVHSQTSTNVLEMTSTIFVGLAYDLLQNQTYNKIQSSEHAIRALNDVSQNASDQLSKLKQMLNVKLNPRIVINRNIPREHLHREFLRVLFEDVVVSGGVAHELDRQLTDFVDALSSLPIESNGEEVAFTFFVSEVNRKTIPGQSYTHPVEVSSIKLHLLRMRTDVYRELIKKQPEAPPHSYKTHKAARHTSHTTAHTRHGEWPLNWSNLWGRNTETQEDEEPEEPDVVALKAQYFIITAEVDTAEFQARREQLEHFFRTATGMGMKEYADRTTKVLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL15</accession>
    <name>A0A5N6TL15_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_169439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742230">
        <property type="protein sequence ID" value="KAE8147025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL15"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025023589" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="677" mass="74195" checksum="1BC4157ED6DD4733" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL29</accession>
    <name>A0A5N6TL29_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_161181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL29"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32621" checksum="CC719CD0E1DFC13F" modified="2020-04-22" version="1">MPPILICQASQSPSLLIMTGRNPVKIQESISALRAEFPEVNYRGLRVDLSDQQSVRNAAAEILNWDDVPMINIVVNSAGIMGIQKRTLSPDGIELHFATNHLGHWLLTCLIMPKLIKAAESSPMGATRVVNVSSTSPQVSGMRWSDMNFDKKNKDLPAEEQPNYPWCAMCGCRDIEDVSYVPLDGYNRSKVANVLFGIAANKRLFEKYGILTLSLHPGVIDTELGRNMSPEDLGAFAELRKGVFKPRTLGAGASTSLVAALDPKLAQGVEKGKSGSENWGSYLHVVRSPLGAELGCKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL96</accession>
    <name>A0A5N6TL96_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_132405</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL96"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="41"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="163"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="579"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1116"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8147050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131247" checksum="397A8DA1D8A4D3F4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLG9</accession>
    <name>A0A5N6TLG9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_143006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLG9"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="7">
        <location>
            <begin position="24"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="453" mass="51182" checksum="B57939E4CEC4E083" modified="2020-04-22" version="1">MASLQPEHYDSIRPHLRHPPFVSNPNQSNIYLFDTKEVSGPKTDGPHVFNNSDTFDVHITKSSRPNARIVSICSQNSMKPLGITEPAMRKLINLYNIDKTFLDLVVSFGDKPQSSDAGHGGMTITHREDGSYDMQYLFAYAEDYNTQGTVAWTIRQVCVFHRYDPTGSGDLWIFLHAKPRSKLQQQIEAEIASQPTGAPPFWYTLHSIVLAAYVGSWRWCIRNLGAEIEKTVDIALTMDLSSTDSARKGLMQLITPQYLGDKLLPLSSRLHATLTTFCMIEEANALFHTRGFATDIEFQKVANEITYYKTNLEGYLESVKVLEGKVKGISDLLAVALNLKNQAVANEINNRMLKLTNESFDDNATVRVVTLVTLIYLPASFVSTVLGMNLVDFEGPNGEGFTVSKQFWIFVVIAVPLTLLTVGSWWVFTRRRLRLQKKRLEEEQMSEKWQETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMB6</accession>
    <name>A0A5N6TMB6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_142768</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="ML742208">
        <property type="protein sequence ID" value="KAE8147430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMB6"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8147430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="572" mass="62283" checksum="EEC547CCD610B33C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMV8</accession>
    <name>A0A5N6TMV8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_142740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMV8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="57610" checksum="4D8C5FB96AC514F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNN6</accession>
    <name>A0A5N6TNN6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_131681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNN6"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="171"/>
            <end position="191"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="223"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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            <end position="303"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="402"/>
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            <end position="461"/>
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    </feature>
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            <end position="498"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="521" mass="57183" checksum="4E7F5F59F5DCFB85" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP47</accession>
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        <submittedName>
            <fullName evidence="1">Tctex-1</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_25778</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule-based movement"/>
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    </dbReference>
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        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
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        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="142" mass="14965" checksum="ECD2A6FA310C8841" modified="2020-04-22" version="1">MAVETSPTSSPIPIADLSKVATEACDSALSNVEGYEHAKVGEWNSQIINTILKALITATAPSDSSASPPYRFTVNSTIVQQGLIDKSAAADGVASNAGKRGMHSASGAFWDVNRDGMWTFKYPGADERGLDVVVSVTWFAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPN7</accession>
    <name>A0A5N6TPN7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_142115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
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        <property type="protein sequence ID" value="KAE8148109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPN7"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="156"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="381"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="580" mass="65061" checksum="9D7DD285670226AF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPU6</accession>
    <name>A0A5N6TPU6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPU6"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="44428" checksum="E37FC7133AA90AAE" modified="2020-04-22" version="1">MFSINSRTLTPALRLRTPVRCASTHASKGPLAGVTVVSLEQAIAAPFCTRQLADLGARVIKIERPGVGDFARNYDNRVNGFASHFVWANRSKESLALDLKKPRDHAILMRLLGKADVLVQNLAPGASARLGLSHDDLKAKHPSLIVCNISGYGPDGPYRDKKAYDLLIQSEAGMLSVTGTGKEPAKVGISIADISAGCYAYSNILAALLQRGNDPERRGVNLDISMLESMAEWMSFPMYYTYQNAPGPTPAGASHAAIYPYGPFETGDGKSVMLGIQNEREWVNFCDKVLGLPDLATDGRFVNNSLRTKNRDALKAKIHEAFADKTSQQVIALLDQAAIANANVNDMQGVWEHPQLKARGRWTEVATPAGPIPALLPPGLTQGGNLPARLDAVPDVGEHNASILAELGIDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ08</accession>
    <name>A0A5N6TQ08_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_17527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742161">
        <property type="protein sequence ID" value="KAE8148415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ08"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="69" mass="7928" checksum="BBC7489135524221" modified="2020-04-22" version="1">MIDLFITTNRGNSSSITTAYTIIIIFETWPSTAVYIIFLSNARSCFYKRRIFFKLSLPSSSLCQVGQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQI1</accession>
    <name>A0A5N6TQI1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_168343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742153">
        <property type="protein sequence ID" value="KAE8148613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQI1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="558" mass="62862" checksum="DBD5367EEFCF14C7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQM7</accession>
    <name>A0A5N6TQM7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_14143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742151">
        <property type="protein sequence ID" value="KAE8148668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQM7"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="288"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="457"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="601" mass="66944" checksum="2DB45BB8D3F10A72" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR15</accession>
    <name>A0A5N6TR15_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tcp11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_158072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR15"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="604" mass="69064" checksum="1A01145433447BB9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRC4</accession>
    <name>A0A5N6TRC4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_157368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRC4"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="690" mass="76138" checksum="0EC8DF6EA463F61F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRD5</accession>
    <name>A0A5N6TRD5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_157299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742142">
        <property type="protein sequence ID" value="KAE8148895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRD5"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000619">
        <property type="entry name" value="Oxidoreductase, short chain dehydrogenase/reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G13830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28128" checksum="735CEF54B6139C18" modified="2020-04-22" version="1">MVLSQPENKHVLKAFDLSGKVAAVTGGARGIGLEVSIALAEAGANVALIYNSSTTASSTATEIASKHGIKAAAYQADVANQEDIEKAIQQIVADYGKLDIIVANSGICSNVPAEEYTTEQWHNITKVNLDGAFFTAQAAARIFKKQGYGNVIFTASVSATLVNVPQKQAAYNASKAAVVQMAKCLSVEWVDFCRVNCISPGFIATDILDIHPKEWREKWFDMIPAKRMAEAYELKGAYVFCASDASSYMTGADLVIDGGYTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRY9</accession>
    <name>A0A5N6TRY9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742134">
        <property type="protein sequence ID" value="KAE8149128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRY9"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="17596" checksum="3BCDBEF16636622E" modified="2020-04-22" version="1">MPLEFLHSYRHAYKLPAPSAYPTEYSQLLLSKGIGLRSPTSIAAQRAHLLRERQAQNTTTDGSQSTTKKAHHPHMTNGTTTAGKGPSGHPSKRSSTNEGKNALNRIIGQDRVSKDHLAIAVRKHFNSAGLAEQEAIARFLYKVREEGRGRQFRLRFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS12</accession>
    <name>A0A5N6TS12_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_130693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS12"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="33875" checksum="A9A0943D55199DE8" modified="2020-04-22" version="1">MRTRNAITYTRYHTSASCFPRYSSYSPMGQADTKPRKKVTIQTLRNLYRKGEPIAALTAYDYPSGLVADAAGMVVVLVGDSLAMVAMGMEDTNEVTMEEMLVHCRSVSRAVKSAFLIADLPFGSYEVSPEQAVVSSLKMIKEGGARAAGIPVMAHIGLTPQRQHSLGGFRVQAKSVAGAAQLLRDVIAVQDAGAFMILVEAVPAEVAALITKRLCVPTIGIEAGNGCSEQVLVQGDVVGNFPLGRDLPRFVKTYADVWGEMIRGIGQYRCDVKSSEFPSEFTYNQAFPQQNPTEFQRLVERSAEGNDEPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSF6</accession>
    <name>A0A5N6TSF6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_141046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSF6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="178" mass="20174" checksum="0A49543A2CC47DC1" modified="2020-04-22" version="1">MALSLCDLERAARTITFVASNTSRLMYFRGPELRPNERVLGARQIVRNHILLIISRDGAALCNFAAQPATRPTTVRMARIDREMNGLFAVLRDSRFWTCDRPKLCVIVSLRNRLGTVMRDEVNRIREIMLMHGEKLSSIITVSGETKGGAVKGEIWVDGRLNPPVVRIEDEVQDWNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSJ9</accession>
    <name>A0A5N6TSJ9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_156691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSJ9"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="382" mass="43085" checksum="07DA31BC5D48D371" modified="2020-04-22" version="1">MPPSRESMQNRGDEDEVCPVCKSSRYLNPDMQFLINPECYHKMCESCVDRIFSSGPANCPVAGCHKTLRKNRFRRQTFEDINVEREVDIRRRVMQILNRREEEFDSKRAWDDFLEQREEIIANLVHGTDVAKTEANLHSYAQANMHSIRANQALEAQEASSFQERQTQEQELARLRREVARQEYENERREMLAGREDVLSRLAAGGPGDAAAIAREGQKVLLKKSSARRSEEERIRQKQAALRGSENKKAGQAALTTADKAGGIGDPSFIKGLKRIKTPEPEKPYDPFGGLAPNKRDYYTLRDYYPSSYLDPLRQNVRAQAGGYDLQEYYSRTLLEAFAGLGCFINEEVAQRDATSSLGATKPVSTEGAAMAASSKSPAESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TST2</accession>
    <name>A0A5N6TST2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_4961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TST2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="115" mass="13518" checksum="FAD7796D5D6B96D9" modified="2020-04-22" version="1">MQCNIRQELITQKTQPHTIKPISIMPFFLSLSLIHFKIQFQVQVQPKHKHVLSTLLFFFCFSFSLPFSSVFTPTSIVILSKQISCLFHTYNNFLFLFIFFSSFCFNNVSSLFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV6</accession>
    <name>A0A5N6TSV6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_2656</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSV6"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8149436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="364" mass="38621" checksum="7DA7857A69DF4DCB" modified="2020-04-22" version="1">MSSYNVVVFSGDHCGPEVTTEAIKVLRAVEKNRDVTFNLQDHLLGGASIDATGSPLTDEALTAAKNADAVLLGAIGGPKWGTGAVRPEQGLLKLRKEMGTFGNLRPCNFAAPSLVEGSPLRADICRGVDFNIIRELTGGIYFGDRKEDDGSGFALDTEPYSRVEIERIIRLAAHLALQHDPPLPVWSLDKANVLATSRLWRKTVTEVMAKEFPQLKIEHQLIDSAAMIMVKNPRQLNGIVVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKSKVNGIYEPIHGSAPDIAGKGIVNPVAAILSVAMMMQYSFGLFAEARAIEKAVSNVIESGVRTGDIGGKATTAQVGDAVAAELEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT04</accession>
    <name>A0A5N6TT04_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_167936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT04"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="129"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="36131" checksum="7FD1D843E2CBCD5E" modified="2020-04-22" version="1">MSGSVQINSKEQFSSLLTTSRFVVADFYADWCGPCKAIAPAYEQLATQLSRPNRITFTKINVDNQQDLAKAYGVTAMPTFIVFERGRQVSTVRGANPKQLSEAVRKLASEAGKPDSEESGESSGGVGWIGAAVPKGYSDITDQYDPKGLELLNRDSEFGTVRTLFDTSKPSSLNSNGKGKAGGAPDWVESDTDEQLMLFVPFQSTLKVHSLHVTSLPPSDGDDDEVPMRPRTVKLYTNRSHVLGFDEADDIPAMQTVEIQPQDWDDKTGTAKIDLRFVKFQSVFSLVVFFVDGDGDSDKLRVDRVRIFGEAGEKREMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTZ6</accession>
    <name>A0A5N6TTZ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_122773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTZ6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8149777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="862" mass="96338" checksum="EDAA41CD2DEDBDA0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU48</accession>
    <name>A0A5N6TU48_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_122138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU48"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="28598" checksum="7030542C9F9F8DD7" modified="2020-04-22" version="1">MEFQKMREGSIGIYSPSSLRLSILLRHGYRCSPDSTPDWIRFLSIHPISVQNHSPPMGVNGASPIPSLFRLPAPSIPSLVQRRRIILYGGSLYCGNPNMGRFAETNPWIKLRVRPEVRRMEDVRYQVLDEKEWHLCSRIGHHCDPGTSTLCFFWIAQARDWTEHLRERSCGGGSKKQRRLCRQYFGLSSCVVHLVFLCAMNLLVARLRVPESGLFLSPDNKELESQCPGLPITMPPMAIPASCSINLPQNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU94</accession>
    <name>A0A5N6TU94_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU94"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="224" mass="24778" checksum="78C619830B0E601A" modified="2020-04-22" version="1">MNLYSYMIVALMAAITALAHMEMKRPFALKSRYDSQNNWSNIDYDNTSPINPNGANFPCRGHHKTTPWRTVATYTAGQRDSMSLAPGVMHRGGSCQISLSYDNGNTFRVIQSYIGGCPLKLDWNFEIPAVAPEGKALFAWSWYNLEGNRELYMNCAHVEIKGGPSSDAKAFDALPEIFVANAGDMSCRTVEHRETVFAHPGKNVEYAGKAKPGDEAFPKCGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUG7</accession>
    <name>A0A5N6TUG7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_155275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8150013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUG7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495:SF5">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="142" mass="16574" checksum="C5D22CF0535BC4E2" modified="2020-04-22" version="1">MKRHQHALNQSPEFAHICRFRRPDAPDLYPWRSHGQPVTMYLALFGCLFILIVADGAAIWHKFHVPLFLSAYLAPMCFLALWLAIKTYRSGGWRNIRWELEDLSNVVEVKEKVQRLDELRERATARDGARQRAGWGNLWGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUH0</accession>
    <name>A0A5N6TUH0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUH0"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="89"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="486"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="58670" checksum="40E59BFD790F4F4D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUY6</accession>
    <name>A0A5N6TUY6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4E3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_154913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUY6"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="344" mass="37848" checksum="5C4DB6FAB8731D69" modified="2020-04-22" version="1">MDHANLWTRRSNSKLSLSMAGTDSKDARVELPRTKRFGPDSSHGRSNPFNALSPLSGGVSSPSTNASSAFGLGSGAFASFGAPKTPGGSDLKTPLEKRDNLAEDAVESLKSKAVGSIKEHPLKSTWVIWYRPPTPKFSDYEKSTVPLASISSVESFWSIYSHLKRPSLLPTVSDYHIFKKGVRPVWEDDANKKGGKWVVRLKKGVADRYWEDLLLAMIGDQFAEASDEVCGAVLSVRSGEDVLAVWTRIDGGRNIKIRETIKRLLGFPIDTNIVWKSHDDSIAQRSAIDQARQEKASGNTGHHHHHHHHHHHHHNNQHHNAGTDRRRATGNDDSTGDKGKGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVD3</accession>
    <name>A0A5N6TVD3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_154732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVD3"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="156" mass="17432" checksum="5CD92FDC37DD310E" modified="2020-04-22" version="1">MNQPQPQQPPPPTLTNPRFTLELEFVSSLANPYYLSHLAVTYPNLLGISNSSEEGDATENNKDPDAQAFAAYLAYLYSYWKTPDYAQFLTHPGATLRALRLLQEETFRRDIIRPDVIEGLAGVSINDDQGGTNPETGEANNEEGKQEDETNNNRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVD7</accession>
    <name>A0A5N6TVD7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F1F0 ATP synthase assembly protein Atp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_155124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVD7"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="40586" checksum="167F997FC9A9C842" modified="2020-04-22" version="1">MWKRSIEPTLVQGGRCLSCQLRHATVTPILRLHSSSLRHNSSKSEAKTPKPVPSRQIQFNQNRAPSSPVSAVPEPGDDDFVPPTLDRPIGSIIPPQEGQNTGVDSRSMRERRDDFVNYDRHLERRKELTRQVAKPYFREWSNLRHHQGKTFYSGSRLFKRDKALYFPNMHGVTLASAGEPQDTTPQLRGRISIVNLFSSVWAENQVVTFTGAVQNPGLYEAMKSGGDHVQKIDINLEENALRAWIVRSFMWRMRAKLPEREHGRYFLVRKGVTDSIKESIGMMNSKVGYVYLLDENCRIRWAGSGPAEEGEIEALNNGVLKLLQERKISMESEKPAQEWEGRIQESAAKPRVVMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVQ7</accession>
    <name>A0A5N6TVQ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_110745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVQ7"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="215" mass="23203" checksum="9EA7FCDEC06208F8" modified="2020-04-22" version="1">MTETNPLRIGIALFPGFQALDAFGPLDCLNVLSWSEPLSLAILAPSLDPVTTKSHRTPTAISQSIVPTHTYASPPPLDVLLVPGGWGTRDLTPELREVISFIGTVYPKLKYLITVCTGAGLAARAGVLDGKRVTTNKKAFHELEAMGPNVDWVRKARWVVDGNVWTSSGVSAGIDVMFAWIGEVFGEEKAKATADGMEYVRCLDPDDDPFAGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW07</accession>
    <name>A0A5N6TW07_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_108759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW07"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="301"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="654" mass="72968" checksum="DEEB14C3689399D1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW95</accession>
    <name>A0A5N6TW95_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW95"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024806847" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="198"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="342"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="586"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="669" mass="70476" checksum="DFA9A9533FEFB512" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWD3</accession>
    <name>A0A5N6TWD3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_154487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWD3"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="508" mass="56113" checksum="0F02D0EF1E1F1A34" modified="2020-04-22" version="1">MRRRITFVQRSDSPFSHDQAILTPDTLTIRSLDAAREDRATFAFDEVLPEIWQVLKHCHQLHIRWASERRYDAVTPFASRVSAGLHVFFTPGSIPGDSLDGLCILLKKVFGDELDCTTPEESFITPPILSTRFASTPTFQYYSSLSSVEGLVSYLENKICGSDSECRAQAERLRSADSVDLNYDSISHSLTVSGFWSRSAEGWSETISKHAAGADQIEIGLLGTERAVEPEEIKMGGLLGVVGRDDQLKPTLFSFPSRHHALPEDATYSVSFPGPTGLHPTMTISLPSSSLNPPPAPPDATCALHSYLTLPSTIFADKYQLSSTDPLFLESHHLVALRAVAGETDLEAPDWSVSNWGSNWLLELATPSDPGQVGEWNVTVPLHLRYLKPSESGYRSASVPWPVVFWACTAEDGTKMGVNPFDRANLGWDGLFGTRTMFYQLHPSADRLVEELEVPVLKLESEGLFQTRMIEVGTVAAIVFGLLWVLWKLGVVARSSTQSEESRQKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWX8</accession>
    <name>A0A5N6TWX8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWX8"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024878172" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19743" checksum="26B13ACAD85D3FD8" modified="2020-04-22" version="1">MALNTVFAGLLALAYFCEPVASLVYIRQSKCAAACGDKSTISDDDVVCPDSSFNSTAEGLTIRDCLLCQSTGTTYVTDERSDTYNFLSNQKFTLQTCLFQRSGETSISSCEDSCHPLRSILTSQWYRTNSTLPIYDYCSSTFGQYAGDCVSCLQGKKGSVILGNFKSLRLRLYRAMSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX40</accession>
    <name>A0A5N6TX40_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_171747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002416">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1313"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="140"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="836"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="792"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8150955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1477" mass="166930" checksum="91354A9BB25A497A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXJ8</accession>
    <name>A0A5N6TXJ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_101821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXJ8"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="260" mass="30417" checksum="AD794277ED208889" modified="2020-04-22" version="1">MSSMRNAVHRRQHKERGQLEGREKWGILEKHKDYSLRAKDYNAKKAKIKRLEEKVRDRNPDEFAFGMMSAHSQKAGKHGAANRASAAGLSHDAIKLLKTQDAGYLRTVGERVRRQMEKLEQEIRVDGDDDEFDFDFDEDDDEEEEAKPKKMVFADDKREQKAMKKKSLREDDEQEKSFGQIKTLKEREAERQVIAEARRARKIKKRAAEARLSKLKALQKQYTDITSAERELDWQRGKMENSVGGTNKNGIKWKIRERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY19</accession>
    <name>A0A5N6TY19_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_139126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY19"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000109">
        <property type="entry name" value="Dipeptidyl-peptidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969031" description="Dipeptidyl-peptidase V" evidence="10">
        <location>
            <begin position="19"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="491"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="725" mass="80233" checksum="27AFEE35202B00DE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY47</accession>
    <name>A0A5N6TY47_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_153396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY47"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="387" mass="42137" checksum="BAF0334C3A743208" modified="2020-04-22" version="1">MSNQQVGTVFDRVIQEVCDGSQVDFEESGVDQQTLLDLQKSWQKKLSSLGVAHFPWDPPPPQPAPPQPQNQNQILPPSATVPSNAPRPPPQAPQHHVPPQQPLPQTMPSTMPPLQAPTPVGPPNAIGQPPHIKTEPGINGQPGLPPMNMMPTNNTPNSQSARERAANMLHQRYGAAAANSVSQLQAQSQAAMAMPGQARPPNLPQVANGQMPQIKQEPGYPPVSQPSMHHSQTDGASDSGLSEWKAEVARRREAAQRQNGEGDRVLRDHLRQRMLQLEGGGLMLPLEEHQPSLAAPSTGTRAQFDGPGGDDERDEDDEDAINSDLDDPDDLVADDHESEDAVGQVMLCTYDKVQRVKNKWKCTLKDGILTTGGKEYVFHKGQGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY54</accession>
    <name>A0A5N6TY54_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_152781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY54"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00568">
        <property type="entry name" value="TPP_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="156"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="340"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="503" mass="54374" checksum="02497CC0D67CA369" modified="2020-04-22" version="1">MEYSLHTDSVGVLFTTTGPGLTNTYTGLRTARTDGAKIVLLSGLTSESEVGNPRPIQETTAGWIDSATNESFQYPFSESIILRHRGDLVHLAQRLRALNDAPAGGCLGVFVSLATQKTLTPPLCSLEITPPVRTQRDAGSLHRWTEYLSTKLQSGNCIIWAGSGAKAAASDLRKVAEHYDTPVVTTLRAKGVFPETHELSLGCTGTWGNVTTDVFRSRLNPNTTVIVLGSRLQGLCSSLIQLHCMSECELIAVDLHPGPVRRNLPPHALVIEAEIKSLLNLLAQNIHNTGTKTNNPKYKLKEYSIPREESKQKDRIHPTSLISMVQSIAIDTYDYKVIVDNGNTLAWTTSLLRFSKVGRFRASTHEAPMGQAACGAVGIGACGTPVLAIVGDGAMLLQNEISTAVSHQLPVIWLVLNDALYNMCQQGMDELGACVPDCSIPETDFALYGRSLGARGFVAKTSSELEDSLWQALEEKVPTVIDARIDSSVVAPLGDRVTSLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ44</accession>
    <name>A0A5N6TZ44_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_152360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ44"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="512" mass="56788" checksum="5FB5B6529BCCF4E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ45</accession>
    <name>A0A5N6TZ45_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiamine diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_171559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ45"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
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        <location>
            <begin position="153"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="4">
        <location>
            <begin position="356"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="529" mass="55952" checksum="788019AAD7B523B5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U078</accession>
    <name>A0A5N6U078_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8152000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U078"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="91" mass="9704" checksum="45E55D5238138B0E" modified="2020-04-22" version="1" fragment="single">MPPTNRIPATNNEPQIQLQKRGPPTLLPPLRGYTTISIPASYGRLASSPSPGTVVGIILGSVLGFIFLLYLVWLGISSGRKFSSETHTVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0J4</accession>
    <name>A0A5N6U0J4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_151583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0J4"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="805"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="882" mass="97457" checksum="8235BAA9067DF4D6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U122</accession>
    <name>A0A5N6U122_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="104"/>
            <end position="127"/>
        </location>
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            <begin position="211"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="36103" checksum="EF2CA88D5A796205" modified="2020-04-22" version="1">MRYTRDKYRSWKEVEKDTGVPWATITNGLHSGKIEAYKSVSAFNEDWRILKQLRTQSTLEKLAETAEPTIVSIKELRMRSDKDPPKPTPTSNSLIPYWSYEKSALAAACIFSAFALAGFIFIIVLAARKIRRSWKRHKREKNDYSEFRHRIELNYDEGDSSLGFVPECKSNRESLMYSHGDSQALGYVVEQEGDSVTRVYRESNMVSSQTFDSIGAPLKKGNSARKSKQISDLRTDARTPSGKGRAGSIPRPIVVVPSPLKHVSSLKATPGSPPTDTNSPGSANSSVSAASQGETKTHRADPTKRFSLLRLPSIKLSKSPMFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1E7</accession>
    <name>A0A5N6U1E7_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_128278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5327538at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="56608" checksum="A301CDFAEAD5D774" modified="2020-04-22" version="1">MSQHPQPKIFTYAHFNLEALCHRVSKLRQDVPCVSTADQRPASGSFNWAVLISFDDGIRWVFRSPHRRFSMPLEVVMKLLASEVATMRYISAYSDIPVPEIFDYCVSCDNDIGIPYILMSEARGWPLSKVWRPVGSPLDDLDASSKGKVLRELGDITWKLSQLRLGRIGSPFEENGSFEVKECLSRGHMLHERYDLEIPRGPFASDAEFYNSLISAFLEHAEALQLSHHCFIAPVPLPNNYEMRTLYTDAVNLWNDFVAVGNKIDSSINRRDYVIAGDALRDILARDIIPSLESPETTEETFPLCHPDLSVNNIFVDDDINITCIIDWAFASSIPEFMLLPAPGLPQYGDEVSSQLRLRFTDGFIAALPESTEKRSVDKYRKSLEQSQLSWKNIGKYFFQQRCSPHYIQILNELQKDDQQPEKVEKEEREYFRNREFRHTIARKLTLVSEWNLQHGVSMPRRLRRDMFVASPKLWKWILEFIQDWEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2U6</accession>
    <name>A0A5N6U2U6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAT family amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_47924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2U6"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="49"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="560" mass="61741" checksum="52E123E386F700E9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Z5</accession>
    <name>A0A5N6U2Z5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Z5"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28604" checksum="8D237F451AF649DF" modified="2020-04-22" version="1">MERAFYSSSEDRSVSTYRAEQEVKSWKAPPLGRLTVEVSQPSHGGSLECCTNNEISTSIMLQLRFDPRGKSQPPQLRTLQPTLKAVTTLTTRPETTHLAADNIVTDAQYQGTSVQEISLPPVDISSAQWVKHSACESSSTPQPITSHTGTSYTASIAVPIILQKSSKLLPTFHSCLVSRIYRLELRACYQMSDTAILHRFVKLDMPIQLNNLQDSNRLNHSPSVSPAPCDNTKQWRIQACTQRQTDTLPSYLDSITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3G3</accession>
    <name>A0A5N6U3G3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_137302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3G3"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="58632" checksum="0895F4654EB6FF78" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Q6</accession>
    <name>A0A5N6U3Q6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_149733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Q6"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="233" mass="24865" checksum="D3CAFC03411E29C0" modified="2020-04-22" version="1">MFTGLVETIGTVSSLEPLDTTASGGGGTSLTITDCAEILADAHLGDSISVNGTCLTVTSFTPTEFKVGVAPETLRRTNLGSLTTNSRVNLERAVLSSTRMGGHFVQGHVDTTATILAVTPDSNALVFRLQPRDRGVLRYIVEKGYVTLDGASLTVTKVVDGADGYFEIMLIAYTQEKIVTAKKREGEEVNVEIDIVGKYVEKSVEGYFNGVGGGNIGILEKMVSRIVEEKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Y1</accession>
    <name>A0A5N6U3Y1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_169731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="271" mass="30020" checksum="7F5D20AF3D82D33E" modified="2020-04-22" version="1">MAGSSMLPKFEPDQDRLVWYLAYGSNLSSQTFRDDRQITPQAAVAVAVPGWRLTLSSAGFPYREPSFASIVAVAPAGPTDEKQDGPCELPLHGTAYLISWSQWIQIVASEGGGIAYDEALVRAQPIQPQDQQRWGAELCVLTLVSTMERWPEPRPSQRYMNLILDGARAAGFPASYISQIRHQHPCYQPASTTWERIGAILFLGFWTPVLALLSLLTHAAARAGPGDDGHVPEGVRALVRLAMFTMWWVHDRLWSRIWGRGDGLLPEGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4B3</accession>
    <name>A0A5N6U4B3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_27869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26832" checksum="1F705F5F546EF847" modified="2020-04-22" version="1">METMADNSTHNYGWHSRSSHPLHPSTMAMEHQPFSQPQTLPPSTTYPVGYGAQQTTSQSFYQPGIPAPQYLCSPHPSLLQGRQPPRGSAMPYSFPSSHVPGSPPTIADQQFTSSPPSYLLNHSDYYYSHGSSLPSNPSSLAISPPSQHIMTPGTVYSSPDSAPTSSDPEQQVRVISFRPKPQCWDHGCNGREFSTFSNLLRHQREKSGVVAKAECPSCGAVFTRTTARNIHVSQGKCKGGGRDASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4D3</accession>
    <name>A0A5N6U4D3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_136794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4D3"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="57185" checksum="B6EF13029115E76C" modified="2020-04-22" version="1">MEQRELKPVAGVRDARDENNQGLHATTQIKRLFSFPQIFFFSLTFMSSWEVQVLTLSSVLANGGPEAHVWGIVIVVFGALAQCASLAEMASMQPIAGAQYHWTHHLAPPRYRKFITWMQGWITWFAWVSLLAGVANTTATTIQGLATANYPEYEPERWHLTLIMFAMLIVESLMNMYAFWLIPWIELLAGVFHVVMFIIFLVTFVALAPRHTARQVFLTTQSASGWNNDYVSWNIGLLTPVWGFVGFDGAVHMSEEVRRARQAVPRAMFWTIATNGILAYAMVICIQFTMGSIDDALAANFPFIEICQQATGSVKAATAMVCGLLVVSLSVNLASIASVSRLTWAWARDGALPRWFAYIDRKHNVPIRAVWLPVFIVMILACLNIPSTAAFGAFTALSSISLFVSYIIAISCMVYNRLHGYHVPLGDWNMGRWGLAVNLFALVYTAYVTVFLSFPACRPVTGENMNYAVPIFAATTIFAFAYWFLGARSRWPGLNKQVLRLVVEGGELRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4M4</accession>
    <name>A0A5N6U4M4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_127100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4M4"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34309" checksum="A78AD1837369900C" modified="2020-04-22" version="1">MSLNFGMKCSTVLPNKPTLTEKNLSDQSGKVFLVTGASGGIGKLLITILYQHNGKVYLGARSESKTKEVIEEIKAAHPSSKGELVFLNLQLDDLATIKQTANEFLAKEDRLDVLWNNAGVMVPPKGSQTKQGYELQYGVNNIAHFLRPALETAAKSAPKNSVRVIWISSSAADAAPNPAIDLTNMDYHRQEGAWLMYSRSKAASVVHSAEFARRTQDTGIISLALNPGNFVTNLQQNMSKMELAMFKLIASDPVNGAYTELFAGLSDTITEKENGAWVSPFGKVEKVRKDLVEPELGGRFWDWSLQQVKPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4S5</accession>
    <name>A0A5N6U4S5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_127101</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4S5"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8153588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="506" mass="57480" checksum="E90B0333677D54A7" modified="2020-04-22" version="1">MSANIAKVSDIDFIQTPAAKPSAFKTEECGVQLTDSPAIHNAPLPADGAGNESFSNSVLAGALIGVPLFLTYVFGGGVKTAIVLAVITALPVLVAFWTWTSSCSPRTNEKVKLPNRPIEQYISFKNEADRKKWQGSNKIPLQTFCEMYLDGLVDFNGDCLDVMEYRHDWSSFRFTWQLFKYIVFTFARDVLFHTQSQDEEQIRPNYDRGNDHYAWFLGPRMIYTSGIISDTEKEETLEEMQDNKMAIVCEKLGLKEGETLLDIGCGWGTLAKFASLNYGAKVTGLTIARHQTAWGNDALREAGVPESQSRILCKDYRDIPRMQYDKISQLEMGEHVGVRRLTIFFRQCYDMLKDDGSMYVQLSGLRQAWQYEDFIWGLFLNKYIFRGADASTPLWYYVKCLEQAGFEIKSVDTVGVHYSGTLWRWYRNWIGNAETIKAKYGQRWFRIWELFLAWSVIASRQGSATCFQILVVKNLNSTHRIDGVPSQYSLSGALDASRKAGKSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4T8</accession>
    <name>A0A5N6U4T8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_149462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4T8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="90" mass="10081" checksum="7FB399243995B14C" modified="2020-04-22" version="1">MCHLISICPNSRAYRPLYSVPCSMGLRFVFPTQEVIGLSESTAGAFSRRATINTSLIWKRISMVTDLGKWLFPRSLRIIHAILAPDGETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U554</accession>
    <name>A0A5N6U554_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_136641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U554"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="52803" checksum="1B959BD3953768E0" modified="2020-04-22" version="1">MPGVPSGRACEACRRQKKKCDERQPTCARCVRLNIPCVGSGQRRFKFQEGYVVPTKEFQHPDKVCHSHSQPRSRDENHTGAEVLGAPPTNAISMLQQAFVRAIHTSTDLNYNLAWAYGGFLRDIPSRLGTNHALDTAADAIISMHSAFCVGRKMSVRALGKYSRALNALRAYLDDPTKACSTDTLCAVMLLLICQGFMGNNNATSSGHAEGAAQILKARRYFGPRDEFEAKLLLSLRGPVLFEGLFTNRIGLSAEEWKALVENDLDGTSPEGQMMRCLARVPGIRDRAATMNAGDAAFESLRQEVRSLYETYQEVLTALQSRTMSVETPLATGPCYLLYTRLYAQYQRMYGLGLTVGIMLNVLLQTVDPDDPMLPLDSMYFAQEILLVAEQSVDFRPLGSHYVILCLLVAWAATPDALIRSTAAQMLDDYQRDFDGGQATEVAAAFVHQLHHIHALPRRCRTRDETEGDDVFQVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U569</accession>
    <name>A0A5N6U569_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U569"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="494" mass="54272" checksum="D82182D1CABCA899" modified="2020-04-22" version="1">MAQHADIKSAGPAPISKRDIQTEIDNEWTSLLKIFDGLRAVTTPGTDEPIKKSPTRQERAGVEGLGVPGPPHPISQVIEEAYTIFDYRLRLNDPSCFEFIPSSSSQLAWLADVLVSAFNANAAGSFTAAVPWAVENALVGWLASKVHFPPTAGGIFTSGGSMANMMAIAIARDTKIRPSEFPKATMYVSDQTHFCLSKAVKVLGFQEHQIKTVTSDSSYRMNIESLRTQVIQDRDNGMCPFLVVASFGCTVTGAIDSIEKIAEVAYNESLWLHVDGAYGASAALSRSRPEIATELEGADSIAWDGHKWLFQTYGCGMLLVREKCRLLSSFQVQSSHIDYLAQNDSEPELYDMGLELTRPARAMSLWFTLRTLGIDRVGALIDHGIDLAEMVQGEVKQLPGWEILTPATLAIINFRYRPGRCTEEQLNKVNSEVSQRLMASNTAAIMTVKLRGKVALRMCCINTRIGCRDVKRLVYVLNNTARSALEDMVLGDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5M5</accession>
    <name>A0A5N6U5M5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_126920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">IBT 18842</strain>
        </source>
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        </subcellularLocation>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153872.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="746" mass="84510" checksum="2E28A2890207EE04" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5U6</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">IBT 18842</strain>
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        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
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    </comment>
    <comment type="similarity">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
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            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="530" mass="58770" checksum="42ED08A9D5DF7C6C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U628</accession>
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        <submittedName>
            <fullName evidence="6">Glycosyl hydrolases family 31-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BDV25DRAFT_167811</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8154103.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        </location>
    </feature>
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            <begin position="270"/>
            <end position="626"/>
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        <location>
            <begin position="637"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="745" mass="83679" checksum="3189393BC83B27B7" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="38761" checksum="CFCAF06C070F1353" modified="2020-04-22" version="1">MRLLPVAAALLSMSQLGLAAPVTEDAALAAISKDLDINELNSLVLRSPNDAHNTLAHLENRDTCTRSGIMIRIIKSTTAQLAFLNIGANIAAEICEHYHDDNCAFWVKIIKYALNAVFLAAQTHGQADGSVGVSPDAEQQSIQRRALESAFADTLGGLLRESGYDYDHMEHFEASGSNYQKRDSDEPDLQHRYIVRGMKNEEFTHDIAFNHYSNEDVVLHLGGMNETLSSDPHADLEKRFSQVGFKVTFATKKASSLSQADQEQMSESIAKDWQVRAASGSTKDYIGFVEDGHTADFYYRIIPEVEGFGLNYESVDVTVGILEDIVEIYEIIIDLFYPYIRKDGSPNGVS</sequence>
</entry>
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    <accession>A0A5N6U7C8</accession>
    <name>A0A5N6U7C8_ASPAV</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Aspergillus avenaceus</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2956254at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="98" mass="10211" checksum="FE8D46B01525190F" modified="2020-04-22" version="1">MRFTGIVLLGLVSLAAAIPAANPDDVSIANNCGYPNGNCYDNDCHGELSADRITCTSGRYLGCQCGYGCGRNTGKCNENGCNGRNGRCTANYLGCSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U7N7_ASPAV</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAE8154618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="61429" checksum="622A422C75FF5E82" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8A7</accession>
    <name>A0A5N6U8A7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_135485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8154842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024790236" description="Cytochrome b5 heme-binding domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="308" mass="33123" checksum="384EE01ACA6ABFAE" modified="2020-04-22" version="1">MGWVGVATLIATACVILYYHPPSTWSSDTPFPQQPESDPKPPTVRDAEVKDEPKPSNEDGTDECQTTPKASASIAPSLEVPTLHLEDNKTTQTTATKEQQPEKPVQNESPKPSIPNIPPPPQQPTANSSSLMPPPPPPRLRPQPLGRAPPRPNPGNSLRPPPSAASSLRVPPSRPPSNSNNSLSPIKLTAQPSTASKRAVLEPGFSPLDWAALTSNPNNKLRGAHLPPTLIKVTPSLLKTQNGRKGRDAWTSYQGKVYNITPYLPFHPGGKGELLRGAGKDSAKLFLEVHPWVNWDAILGDIEYGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8B2</accession>
    <name>A0A5N6U8B2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class IV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8B2"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="282" mass="31415" checksum="78B181654872F5F8" modified="2020-04-22" version="1">MSTMRTESVAPSGDFQIISTLRFDPSLPNAIEQRNVESFPKSPYYLLPYHQTRLLNAARAVNWPKAVGFCEQGLDGLVRIFDNFIPDKTKAWRLRILINNEGTCKVEANPTTIIDLNTLFLPSEDRPRSDPWLVYVDTEPTTPSVFTTHKTTVREHYTAARLRAGITSPQMPAEVLVVNLKGEIMEGSITTPYFQLRKSGKEDMGNDSSPKWITPPLSSGGNAGTTRQYALSQGFCTEQVVTAAEIRDGEECWLSNGARGFVPGRIVRNASNGSRCNDDREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8P3</accession>
    <name>A0A5N6U8P3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8P3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="40478" checksum="71D22D116154BB9E" modified="2020-04-22" version="1">MDIQRQCPGVHWVWEGGISFVYEVHPLKSGEEEREQFHKELKIYEILSQHPPCPSVVQCFLYTTDGIFLEYMRDISLAYRKQFNMTRNQETRVVTKVNTMEPLPLRKQWMNDLAQGVAFLGSLNLAHGDLRAENILLDRDQLKLSDFDCTAEFGTDFETCPCPYGRLLNDTEAEQGRPGTAGFLGPRTEQFALGSLYYLINYGFEVYDDQCLAGDPYEHGPKVVDLLQRMEFPSLDGDPVIDDIIDKCWHNQYPTLAELASHTEALLKGSSSEVPNPGADSTPTSIPVDRIPRDNGKVPSDDCRDVNQNSGMHFSKQEFCRDLEKRGLLRLLTSGTPTELGFRMEHRYVLETTPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8R5</accession>
    <name>A0A5N6U8R5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alb1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_135316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="192"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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            <end position="71"/>
        </location>
    </feature>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="192" mass="21425" checksum="1A50D408ED1E25C5" modified="2020-04-22" version="1">MAKTRSQSKHSRAARRAVSPSADVDKSLTSLPRAESTVVQRESILSERANAGVTKKQPKPKAKSRVQRARQQKGIDRAELVLDQLEKKVEKSVTRGKTVKERRVGWKLFAGFMWDVVNTSHIQAEWEDLNRKSGSTMFQALNDEAEDNNDDDAMVDASAAPQKSKQQPQPTFAVQNPVTDDHADIDVDDDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T0</accession>
    <name>A0A5N6U8T0_ASPAV</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_135371</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="47473" checksum="4108B218E0890C31" modified="2020-04-22" version="1">MSSVPLPIQITSPQIWNNYAARYDVEKSNIFQLQCYNSASKIGIPQYLALRAIWSFDAPTKFKAHECGIQAVEKARGLLRKLPFWKEFLQTVSKHVPVDKVLPVNHAIGDFKLIWYGQQLIYWGQSTKDNEGNLDFSPPRAKPKTRAGVIPEGDDEDPFTQSPQHTRVGSLMERFQEFRIDDCLPDKQIATPSREEWIEQEPETPADDIDGDPDYVPEDDLDMEPETFDPVSDENVVNSYFVNFANAVTISIKGMKAHWTQERKAFIVCDKGKRKIYEARTDGHLSLPDGNHSLAIIEVKPAFRATIPRVMMQETAQMAAWINNEPDIDIDTSPKDKRFRHLLFSQNRHEIFLIVAEYDAGYIDYIRDPDGRPESRSFLMMKQFGPWRITNADDVMQIGSIILAVTLQLADGIPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Y3</accession>
    <name>A0A5N6U8Y3_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_135408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8Y3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024820426" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17902" checksum="4D4E0F7B737CA6A7" modified="2020-04-22" version="1">MRAFYTFLFLVYIFFGYVTAEPQPAEPTRDAKMDLSYIMDPNDEVKGVHSTTNPEAEATPSPQPTSFKKLDVFTSSGRIQRYTLDDGVPRFACILERNWHIEKFKKRIKKECPEREEPTDGGKCGILMRRNEQGVWRAVRARCKREEGSTENQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Y4</accession>
    <name>A0A5N6U8Y4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_126216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8155068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31989" checksum="8ACD046A5E96ABD0" modified="2020-04-22" version="1">MVNVAIAGGTGGVGRTILEVLQATSQHQAFVLSRQASQHLPNTITMNYDDTDRIADILERKNIHTTKRFVPSGYAIPYPQRALEFLPQLNDYFEAIYELRRSGLEWTVFHNGIFLDYFGTPALTSYLKPNVFVIDMEHKVAAIPGDGNTPVTFTYTFDLARFIVASLDLEKWDEESRVIGDEKTFNEFVALAEEARGSKFQVFYDDVEKLQRSEITELPGHKALYKQIPKESFQWFTSIFERFTADGTSHIARAGSLNERFPDIKPLSVKNMLDRYWKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Y7</accession>
    <name>A0A5N6U8Y7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8Y7"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8155046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="523" mass="57251" checksum="7271260C0C53CB38" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9T9</accession>
    <name>A0A5N6U9T9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9T9"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="202" mass="22257" checksum="F550D540B13096EF" modified="2020-04-22" version="1">MTSATAKSSITLQPETALSRGLQIPTKSSHITSGFEYPPILQTHNISPADWSNFTSEITSQARLTRAQWSTAVGRGLGVLAVGGLMIGFLGAIPAYVVARKVQRNREEQNMVAATGEDGLGRTIREWNEGFFEPRGVVIRVDLPFEEVEDIGMMDVFGSAEREGVKGWWEGVRGRRREDAQRKARIVIIPIPMSEVEMEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD16</accession>
    <name>A0A5N6TD16_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_167505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742715">
        <property type="protein sequence ID" value="KAE8144170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD16"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="841" mass="95597" checksum="BAEA52BAB45BBC6F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD68</accession>
    <name>A0A5N6TD68_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_100561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742582">
        <property type="protein sequence ID" value="KAE8144293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD68"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001908">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_6G12600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="611" mass="65834" checksum="0C09C045821A2993" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDJ8</accession>
    <name>A0A5N6TDJ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_105261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742648">
        <property type="protein sequence ID" value="KAE8144219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDJ8"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28093" checksum="087CD8D7C01FC7CE" modified="2020-04-22" version="1">MATSVSLVKTPRRFLFIASIGNPRPYRHTRHSAGHILLDALIPLLPPRFPLVSTKNHSSAGPIFYRTWYSSSYMNESGPKLARQLKNWISTTQTEVLGKIVQPGHVALSRTVEVAEAEGVECQRRGLDPQLIKHFDPTLVILHDELEAPLGKVRVKRGGPEKASLRGHRGLISVMESLRGKGLYPSPTSSGPNSTQGDLAVLRIGVGIGRPSTRNRGDVADYVLAELNATELAAVRSAAGPVLDILADEIYRDRDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE58</accession>
    <name>A0A5N6TE58_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_145688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742548">
        <property type="protein sequence ID" value="KAE8144371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE58"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="170" mass="18533" checksum="262C4191C23CAC6E" modified="2020-04-22" version="1">MLLQPNDVPESAESEKRAILTIQPRIPAGSLAFPEIPAGMLDDNGSFAGGAAKEIQEETGLTIPQEELVDMTSLALQSVDNPEGGETLQNAVYPSAGGSDEFIPLFLYQKRMPRKDIESLQGRLTGLRQDGEKITLKIVPLKDLWRTGLRDGKTLAAWALYKGLKEEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEK5</accession>
    <name>A0A5N6TEK5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_91129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742488">
        <property type="protein sequence ID" value="KAE8144549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEK5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="91" mass="9922" checksum="954086D6080C9C34" modified="2020-04-22" version="1">MSFTAAHPHSLLLISSAQENSGFSMFSPGLPTCSGLHFPLVLTSVSHRKKAGGVLDNLRLPFLSVRVTAVKKTFRPFIPDRQTSELVMCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEN8</accession>
    <name>A0A5N6TEN8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_165963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="ML742427">
        <property type="protein sequence ID" value="KAE8144835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEN8"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="128"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="53194" checksum="16F4F5113D219637" modified="2020-04-22" version="1">MKPAARPLRPLSGVSSSVRYVSRTSNPKSSVATSTAANNVWHQVPQSSKTDSASPLAKLPLSSVLRSLLILSVSSSSLLLKPCIYTLTQLAHPKTPVLDVAKNPLLNFLIKHTIYKQFNAGENKLEVQRSIEDIKRLGYRGVLLGYAKEVLVGESNVDPMDEKAAREEIQAWLDGTLQTVDMAQEGDFVALKFTGMGTQVLQFLQQRDAPSEFMDRAIQKVCDLAISRNVRLLVDAEEQAVQPGIEEWAMKYQKYCNSQSPGSAIFYNTYQAYLCSTPANLARHLEMSRQDGYTLGVKLVRGAYLKTEPRHLIWSQKEETDKCYDGVVEALLTRKYNSMLKSASEEQKTDLPPVNVIIATHNRDSVRKAHALRTEQAMKGENHGVDLSYAQLQGMADEVSCELLEGFQSAESMKGASMETPNVFKLLTWGSVKECMGFLMRRAIENTEAVGRTKQSQEAMFDELRRRARDAFRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF12</accession>
    <name>A0A5N6TF12_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_88105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML742453">
        <property type="protein sequence ID" value="KAE8144691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF12"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025092939" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="377"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="534" mass="57771" checksum="FEDE1E89BCED63C5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFI4</accession>
    <name>A0A5N6TFI4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_165906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ML742423">
        <property type="protein sequence ID" value="KAE8144861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFI4"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="177" mass="19522" checksum="39C6DCF14B833E12" modified="2020-04-22" version="1">MVETGLPAGWEVRHSNSKNLPYYFNPMTKESRWEPPSGTDTETLKVYMANYHSGPAGRPDGSSQGDGKIRCSHLLVKHRESRRPSSWREADITRSKAEAIEILRGHEARISSGEASLGDIAMSESDCSSARKRGDLGFFGRGEMQKEFEDAAFALQPGQVSGIIETASGVHLIERIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFJ2</accession>
    <name>A0A5N6TFJ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_81717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742419">
        <property type="protein sequence ID" value="KAE8144889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFJ2"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="175" mass="19294" checksum="49FECE696EF5DA1B" modified="2020-04-22" version="1">MTVFSLIIINKAGGLIYQREFQPGLRKLSTNDYLVLAGTFHGVHAITRSITPKLPVAAATTTASTPTSSNVPSTPGTPTPITPASTHSFPNPGVPATGLESLETDKFRLTCFQTLTGTKFLLFTDPMMTSIDTVISKIYELYSDYVMKNPFYQLEMPVRCEAFDRHLMGWLRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG05</accession>
    <name>A0A5N6TG05_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_165497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742394">
        <property type="protein sequence ID" value="KAE8145049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG05"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="36885" checksum="4E408E6A00694424" modified="2020-04-22" version="1">MSIPHTQTAAVLPASGASPDAQLQIRTDRPIPSPAEGEILIKLEYSGVCHSDVHSIRGETPMLTDVAGHEGVGKVVMVGTGVENEWIGTRVGIRWLYSSCLNCEICAINNTACPFQKNAGANVPGTFQQYVVSPAIHVTRIPPELSPDAAAPLLCAGIAMYSSIMKTKTRPGDWIVLPGAGGGLGHMGVQIAVKKGLKVIAIDSGEKKKQLCLALGATAFLDYKVDDIESEVQSLTGGLGAHAVICTANGEQAYTQSMRLLRRLGVLVCVGIPSVPFKLPATPFDMIVKGLTIVGNSAGTAKEMEGLMEIAVAGDVRAHIECFGLDEINDVVQRLGRSEIDGRAVVKIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGC4</accession>
    <name>A0A5N6TGC4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_164767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742350">
        <property type="protein sequence ID" value="KAE8145392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGC4"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="341" mass="38586" checksum="75B6F9F159E90289" modified="2020-04-22" version="1">MDIRKTRTSRQESTTSSYYNTSGSVSKRKRKVLEDTNATPTSVKRHRNGAVNQVAVPARSVEVIDLTRDSPPGPAEHVGSARRRTKKSPDGTAPERRARVFRKHPPKSYLERLARATTQRMFVVGHTVTGADDVPQMNFDIVGTTGNMYKTVIGKVPSCDCPDASSKGNQCKHICYVLDIVLKAPQHLQYQLAFLSTELREIFQASSLSREVSKSEDNGGRRKAIDGDCPICFMEFEPDKEEIIWCQAACGNNVHKTCFQQWASTQRTQGVRCVYCRSQWQMDTSDVNLEQLKRQGRTNAAGYTNVASQMGLSGRRDYSTYHPYWVSRQLFRYGSRRREND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGP9</accession>
    <name>A0A5N6TGP9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_164397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742334">
        <property type="protein sequence ID" value="KAE8145554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGP9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="70" mass="7596" checksum="12DAB636708D874E" modified="2020-04-22" version="1">MRTVISFFPFTAFPTACMSTDVGNIQKFLGLMQRCLSPFSGQHEHIVPGGGIHAGSHTIRTQARVKPSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THF4</accession>
    <name>A0A5N6THF4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_69430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742337">
        <property type="protein sequence ID" value="KAE8145531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THF4"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="32677" checksum="79C0576B484EBA11" modified="2020-04-22" version="1">MVKRKQVKDGDVEMGGTDPRVGDDSDEEMDIVNVDFEWFDPQEIDFHGLKILLRQLFDTDGQIFDMSALADMILAQPLLGSTVKVDGNESDPYAFLTVLNLQEHKDKPVIKDLTAYLARKASSNPSLAPISQLLSQTPVPPIGLILTERMINMPSEVVPPMYTMLMEEIAWAIEEKEPYTFSHYLIVSKTYEEIESKLDMEDARPQKKKKKSGDKGERFHFHPEDEVLERHAVCAGSFEYTHKHDDGHSDSKRAFQELGIKTGGSLMLLDANKLEGAVKDMTNYMNPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THT5</accession>
    <name>A0A5N6THT5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_163595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742303">
        <property type="protein sequence ID" value="KAE8145892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THT5"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1320.10:FF:000012">
        <property type="entry name" value="37S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="103" mass="11605" checksum="87A8CA5D82AC9944" modified="2020-04-22" version="1">MVVRIRLARFGNKHQPFYNIVVAQARTARNSKPLEVIGTYNPVPQRPTNLSEEEARSARPYKDVALDRSRAKYWLGVGAQPSDSVWRLLSLAGLSESKEKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI54</accession>
    <name>A0A5N6TI54_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742290">
        <property type="protein sequence ID" value="KAE8146058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI54"/>
    <dbReference type="OrthoDB" id="3348320at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="48"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="216" mass="24559" checksum="C99D2F41E5840E58" modified="2020-04-22" version="1">MFRRKQYLEAEDFYQGLALLDAKLSVIPVVVAFAPIKVIAAGGFFAVAHLKNRPTTKDLDYLLEPDWANDDDIKQSLREAIADVADELGYPQNWANEDVALFVTKQARKRLMDRAVEQNIVLWSGDYITVLSAPVEWALERKLRRIYAADRGRKAELDLSDALAMLNLLKNTQGGKLDMEYYRTLNINGFDVVPSPEAMLRVAAAYRARYNEDIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI55</accession>
    <name>A0A5N6TI55_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_58468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ML742294">
        <property type="protein sequence ID" value="KAE8146012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="3705"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        <source>
            <dbReference type="EMBL" id="KAE8146012.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="4030" mass="449227" checksum="F51B0E46904CD967" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI57</accession>
    <name>A0A5N6TI57_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_163324</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8146026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PRK13529.1"/>
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        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malic_M"/>
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    </dbReference>
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        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="13">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="12">
        <location>
            <begin position="285"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8146026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="582" mass="64978" checksum="229C6DF3F9D51595" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIC6</accession>
    <name>A0A5N6TIC6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_163714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742307">
        <property type="protein sequence ID" value="KAE8145851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIC6"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="291" mass="31650" checksum="1662DB1744EC4E6E" modified="2020-04-22" version="1">MASLLKQPLKLALVQLASGADKAVNLAHARTKVLEAAQAGAKLIVLPECFNSPYGTQYFPKYAETLLPSPPTQDQSPSYHALSAIAAEAKAYLVGGSIPELEPTSKKYYNTSLVFSPTGSLIGTHRKVHLFDIDIPGKIRFKESEVLSPGDQLTVVDLPDYGKIGLAICYDIRFPEAAMIAARKGAFALIYPGAFNMTTGPLHWSLLARARAVDNQVYVGLCSPARDMEATYHAWGHSLVANPSAEVLVEAEDKEAIIYADLDNDTIQAIRKGIPVYTQRRFDLYPDVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIM5</accession>
    <name>A0A5N6TIM5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_162995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742281">
        <property type="protein sequence ID" value="KAE8146177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIM5"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="140" mass="14785" checksum="34AFBECB53E8CB6C" modified="2020-04-22" version="1">MSKRGRGAASGNKLKMSLGLPCGAVLNCCDNSGARNLYIIAVKGVGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVVVRQSKPWRRPDGMYLYFEDNAGVIVNAKGEMKGSAITGPVGKEAAELWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIZ3</accession>
    <name>A0A5N6TIZ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_162725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="ML742271">
        <property type="protein sequence ID" value="KAE8146315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIZ3"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="250" mass="27132" checksum="E2CA75ECA980016C" modified="2020-04-22" version="1">MADQADAPQTNKAFVPLENNPEVMSHLVHQLGLPPTLGFTDVFSIDEPDLLAFVPRPAHALLLVFPVSPSYENSRINEDSTLSEYTGSGPSEPVMWFKQTIRNACGLIGLLHSVSNGEARAQVLPGSDLDALLRDAEPLGPVQRADLLYESKALESAHADAAKLGDTTAPEAEDAVDLHFVAFVKGVDGRLWELDGRRKGPLERGVLREDEDALSERALELGVRRFLKTEADGGNPDLRFSLVSLGPVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ93</accession>
    <name>A0A5N6TJ93_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742261">
        <property type="protein sequence ID" value="KAE8146448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ93"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14190" checksum="05FB36DD11B3F20F" modified="2020-04-22" version="1">MSNRTGLYAALAAAGAGGYYLFRAGGDPKAAKGELKHDVDVARSKAPSTDQAEKSGERVGSEAGAHIDEAVNNARTQAQQASNSASGLAQESLDKFNDVKDDASAKIKANVDKFDKTVEQKTSEAKGTVSSWWGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJK0</accession>
    <name>A0A5N6TJK0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742257">
        <property type="protein sequence ID" value="KAE8146526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJK0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="340" mass="37049" checksum="1916DFAA17E59F01" modified="2020-04-22" version="1">MDPVREARPCRDCGDVRTSDSPLCNACQQLQDLTHSERNTPPLMQIPLHEEAAASNPEDGGTTVPNTPVPGSPVAASGEGMSREGTAGEVTYLGDAVAPNTPVMSPRGTVGLPSRETTPARAGKGKAVMRVADDDAEKEESEAVEVEREASVDVETTKASQPVKVRYGAACPDCKRSKIRCKHRAELKEGEIGNPPGRKRGRQAKSTASKSETARLAAAEPAKRELRTRFVDTSAEPLSAPMKTRGRPRKRKSPERSEAEVVEDAEAERPPSPKRLKRRGAITAGDSLDIAAQLVTHHEASKKLGEQLQELSERWEEVSDVVLRIQELLRLWLEKYQRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK80</accession>
    <name>A0A5N6TK80_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742245">
        <property type="protein sequence ID" value="KAE8146725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK80"/>
    <dbReference type="OrthoDB" id="2947935at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024814093" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15097" checksum="8ACEBDCC598066F4" modified="2020-04-22" version="1">MQRILKIALITLATITVANADFFSACMGHFKLTNPLYMLEATCRNNAGHNITSELDLSLCWAEKRKDTSGGFQCWKCKALNGTAISAEIGESGPDDTIPNELVCTCTSKGDTGGGAEELKDNVIAEDGLLKCWEHTGKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKH4</accession>
    <name>A0A5N6TKH4_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742239">
        <property type="protein sequence ID" value="KAE8146846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKH4"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="624"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
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            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
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            <end position="125"/>
        </location>
    </feature>
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        <location>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
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            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="645" mass="69386" checksum="359F171B11D6CCAF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKS5</accession>
    <name>A0A5N6TKS5_ASPAV</name>
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        <submittedName>
            <fullName evidence="15">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_43084</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742233">
        <property type="protein sequence ID" value="KAE8146954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1780:FF:000003">
        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="109"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="671"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8146954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150770" checksum="D7860BA57428C29E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL06</accession>
    <name>A0A5N6TL06_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_169637</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="ML742243">
        <property type="protein sequence ID" value="KAE8146771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL06"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000027">
        <property type="entry name" value="Probable exopolygalacturonase X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025011535" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8146771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="434" mass="47295" checksum="832FF729BA54911A" modified="2020-04-22" version="1">MKFKLTQVAALLSLTQSIQAEGISRSRTNAIAPQPPFRPLPSSLPRNRTCHVTSAGDGTDDSPAILSALKECNNGGKVVFDEDTDYTIGTALDMTFLRHVDLEILGKITFTPDTDYWQENSFKHTFQNATTFFNLGGVDVNVYGGGTLDGNGQVWYDLFAEDKLILRPILVGIIGLHGGTIGPLKLRYSPQWYQLVANSSDVLFDGIDVWGYSSSENEAKNTDGWDTYRSHNIVIQNSVINNGDDCVSFKPNSTEILVQNLHCNGSHGISVGSLGQYPGEVDIVKNVLVYNISMYNASDMARIKVWPGSLAEMSEDLQGGGGLGTVQNITYDNMYIENVDWAIEVTQCYGQKNITLCNEHPSNLTISDIYFNDLRGVTSGKRDPNVGTVVCSSPKVCSNIHATNIDVESPSGDSDFICTNVDEDLLDVNCASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLG0</accession>
    <name>A0A5N6TLG0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_169270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLG0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="509" mass="56428" checksum="C393F301F252A295" modified="2020-04-22" version="1">MAGVKAHHYKPPRASGDIDDLKHDPDATINKDVDLGLVLQVDTTPEQERKVLWKLDLILIPLMGICYMMQYMDKLALSQATMFNLREDLNLVDQQYAWTSAVFYFGYFAWSWPSSYLIVRLPIGKYLSASVLLWGGFLMCHAATNSFGGLMAARFFLGVGEAAIAPGFSLITGMFYKREEQPARQAAWFFGNCISTIISGVVAYGIGSIEIDTVESWQLLFLVLGAITAGISFFLFVFLPDTPMNAIFLSKTERSIAVQRTLKNKTGVMDSGEFKWNQAWLAIRDPQTWFLVLYTFCVNMCNGGVTSFSSIIINGFGFSEIKSLLMQMPLGAAQVVFLLITTGVATFVANTRVIMMVLNTTVSMIGMILVWQLDDDAQKGRLTGLALGATFAVNIPLSLSIISSNVAGFTKRSTTSGLLFIAYCVGNIVGPQFFVSSEEPHYPTGMKAAISGLALGVFFLICLLLYYIVENRRRDRVYGNPSQLTEADQRMQGLSNKTDLEIESFRYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLS0</accession>
    <name>A0A5N6TLS0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_160682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742215">
        <property type="protein sequence ID" value="KAE8147288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLS0"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="792" mass="87526" checksum="4AF755DD62EEA8A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLS5</accession>
    <name>A0A5N6TLS5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_169422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLS5"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027151374" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="12">
        <location>
            <begin position="105"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="28684" checksum="1591A0C386203C8B" modified="2020-04-22" version="1">MKMIKSIFLQTVLALSTLTSVHGADSPGCGKHPTLSNGVHRISDREYILKIPDNYNANKPHHLIFGLHWRGGNMNSVVNGENVEPWYGLETRAQGSAILVAPNGRNAGWANTNGEDVSLIDAIIKQVENDLCIDQSSRFATGFSWGGGMSYALACSRAKEFRAVSVLSGGVISGCEGGHDPIAYLGIHGGSDPVLPFDGGVTLANKFVANNGCKPAYVGRPGVGSHSSVRTDFQGCSKPVSFIAYDGGHDAAPLGVGNPLAPDATWKFFMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM84</accession>
    <name>A0A5N6TM84_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_132073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM84"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="277" mass="30976" checksum="9D0BF0C8C2B6327D" modified="2020-04-22" version="1">MADLFHRASSFLFSLPGTLPPSLRQPSNNVRLTVSALSATILAVTVPRIYRDYKTFLSYGPGGVPYNFLGWFGVSVIMRPWAREMLSTEPYNHLIAAGETTSYLTDEVVQGKKRDRPEVGPHIAPQRQLTEFPPEEIKKKLDADFYALASRNQHLIKLSPSHVELHADAFFLADGLSPSPIAQQMKGEIAHIHHLKDFSLHLTLAPADCKKIIENGWGQRHKLSGVKIPRALFAGRDISIPLEYVFIYAPRTEEEVAFVMEIVVASVKFMTGAVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMK1</accession>
    <name>A0A5N6TMK1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_30307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742200">
        <property type="protein sequence ID" value="KAE8147586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMK1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="38830" checksum="541E2FBB050C55B6" modified="2020-04-22" version="1">MANATIVALWVLTWCTVGLISLRLILRKVRGKALVLGDYLSLCAILCALIRLALVHVIVIWGTNNMPQIVRQTHHFTSQEIYQREIASKFTLVNRVFYNTYLWLQKFILLDTYRHLLRNLSWERITISSYLFIFLATYATVQIVTFTECNPFNHYWMVLPDPGECARAQLQLIVLGVLNIVTDLMLIVLPIPLLVKVKRPFLEKLQLAGLFAVGLFIVVITIVRLPENASHSTAQVNRTTWASVELFAAAIVANAPVLYGFYRGKVEESRSRTTTGGTTAQQTSTGRGGTITQNQDWEMQSMPGEHVRRTSMLGSKRISRPMRGYTELDEDGETLNKDVRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMX0</accession>
    <name>A0A5N6TMX0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_159908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMX0"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="457"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="641" mass="69915" checksum="BA0F8E51107DA396" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN22</accession>
    <name>A0A5N6TN22_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_132007</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN22"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852810" description="Probable aspartic-type endopeptidase OPSB" evidence="14">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="64"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="482" mass="50176" checksum="EB34DE6276C69348" modified="2020-04-22" version="1">MPRLSTLLPFALTALAGVDALSLYKRDAPATLELPITGYRSSRPLQKRDSTGEIPVTNGMLSYYSLNLTLGTPAQHLSLALDTGSSDIWVNVADSDYCSGKGDVCKPYGFYDSDASSTSKSVGTSFNNTYAGGTNAYGPYLTDKLKMGDVEIDHMQFGVAEQSTSRQGIVGIGYDTNTNQGQKGKIYPNLPQALVDSGAIKSPAYSIWLNDLLASQGSILFGGVNKAKYHGSLQSVPVIPVYGRYYSLAIALTEVSVENGDDSKSIDTTLPLAVSLDTGSVLTMLPKKLVDKIYSELDATYVEKYGVAYIDCDKANKDYSIKYSFSGATITVGIDELVFPAAEPGFPKGTCIFGIVPSAEGVNLLGDTFLRSAYVVYDLANNEVSLANTNFKPGDEDIHEIGTGTDAVPGATRVKSAVSSATGNGVATATAGGPTLPGVTQTAVAGTGTAAAESTSSGLGAMPTGNIKLLSGLAGAGLLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNE1</accession>
    <name>A0A5N6TNE1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_26728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNE1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7101" checksum="78AB0AF954167B45" modified="2020-04-22" version="1">MEGMVEEFVAIGLFKYSSVGCMCFPLACLCKCTKEVNWNGQRVLGAFVVCTVFVSWSYWWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNF6</accession>
    <name>A0A5N6TNF6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_25915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742186">
        <property type="protein sequence ID" value="KAE8147874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNF6"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025074647" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="311"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8147874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="462" mass="51316" checksum="828B85EB7A1444B5" modified="2020-04-22" version="1">MRWSLSLLLFGFLAVVHALSSSGNRLLVVLEDAAEKDSFSKFWSDLEARGYDLVFESPKSDKLSLFEHGEKAYDHVLLLPPRSKGFGPSLSPKNIIEFMNKDGNVLLALSGKSTTPSAVSSLLLELDFHLSSDRSSIVVDHFNYDTLSATEKHDVLLLQQPGQLRQDTKSFFGGSGVLAFPRASPHTLGGSNPLLTPILRAPTTAYSYNPKEDAASVEDVVATGSQLAVVSAMQARNSARFTLLGSVESLQDAWFDATIKAPGDGKETETANREFAKQLTAWTFKETGVLKVGKIEHHLAQDGDLASVELNPKIYRIKNETVFSIEVSEYNYDQYVPFEVPENDALQLEFTMLSPFHRLDLQPSGKTENSTIYSAKFTVPDQHGIFSFRVNYKRPFLTNIEEKHEVTVRHYAHNEYPRSWKITGGWVWIAGLWSVVGGFLAFVVVWLYSAPTSAAPTTKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNX4</accession>
    <name>A0A5N6TNX4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_142377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNX4"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="51"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="50332" checksum="647E90857DA33E53" modified="2020-04-22" version="1">MAQKLPKTSEGFTWTPTGGYSRGLSTPAVVPSTSEESLLSRYDVIVIGAGFAGLSAARDLALAGKEILLVEGRDRIGGRAWTAYDDFSGAKFEMDEFEVTHPYAKSGEVHVKRSKDESVQVRGHHTAMPDTADAMAKLLDVDGNGGKSVVSFPFNTRSSVAANPAYMEADKLSVVDRAGQIDVTEEQRKAVVELASSFFGLLGEETSFLELLHMNSLCSFNEALVEEATMRYKISRGASALALAILGDFKGHRMMSSPVTAISQTQDGCKVTLSSGKELFSDKVVSTIPANVALSIQYNPPLSSLSQEALTNGLSAARIDKVLATTSKNLDEGLHVMCEGGDMPCLNGFADGRHQKDQSLITLLAKPDVDLDSCDHNMSLLNSLNPDGLGVTSVRAHLWSKDPFAGGVMACRKPGFVLRYFEEMRKPHGNVFFCGSDWADGWRGFISGAFEDSYRVTREFLRGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPG9</accession>
    <name>A0A5N6TPG9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_168598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742171">
        <property type="protein sequence ID" value="KAE8148187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPG9"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="524" mass="56641" checksum="69875A78C3572603" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPW9</accession>
    <name>A0A5N6TPW9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_19772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742165">
        <property type="protein sequence ID" value="KAE8148330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPW9"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15134" checksum="FFB94DB27BEFCD4A" modified="2020-04-22" version="1">MTDAEPLYVYKLVSSSSPVREPLPERLPVSELDQTSGFIHLSTAFQVPNTLKFFFKDEPLVYVLRIPFKQIAAQLRWENPEGTVCGPRPKEGLFPHLYNDLKLGKEEVESIAILVNESGWDEAISKATPWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ66</accession>
    <name>A0A5N6TQ66_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_168409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Machida M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742153">
        <property type="protein sequence ID" value="KAE8148619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR55"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="11351" checksum="612185C6F9929FC1" modified="2020-04-22" version="1">MGGCPLESEIDFRMPDDVVNGPALFAWSWFNLVGNWEMYMNCADVIIHGGSGNIDSFTVYPGLFLANVGNGCSTVEGKHTVFTHPGNQVFYADGIDASTPPFPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR57</accession>
    <name>A0A5N6TR57_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_130909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742146">
        <property type="protein sequence ID" value="KAE8148780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR57"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17114" checksum="610F2723406068C5" modified="2020-04-22" version="1">MKSYREALLQRTHSLTSAFSNPSTPLSDLLSNFTTDPVPTAHEHGLAELAPFLGREFKGHEGLKQYFGLLDEYLVIERMEFEDSHRWGVDVELGVVVLRGSARFRAKETGKGWDETFVYRVELVDLDGGEVKVCRYEVWADTGALYLARCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRH8</accession>
    <name>A0A5N6TRH8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_130781</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742140">
        <property type="protein sequence ID" value="KAE8148963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRH8"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000028">
        <property type="entry name" value="Putative transferase caf17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="95"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8148963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1232" mass="135968" checksum="4FDE59660AC4D045" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRJ3</accession>
    <name>A0A5N6TRJ3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742147">
        <property type="protein sequence ID" value="KAE8148769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRJ3"/>
    <dbReference type="OrthoDB" id="4757558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="589" mass="66880" checksum="3B476A2B1A1FD68D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRS5</accession>
    <name>A0A5N6TRS5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_168063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRS5"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="644"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="769" mass="87987" checksum="D7565068861D5FAE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSS7</accession>
    <name>A0A5N6TSS7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_156425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSS7"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="331" mass="36735" checksum="ED873CBFF800A920" modified="2020-04-22" version="1">MGFGDFDTICQKAALPLCSLVGPASSISGSTGIIPNCYARNIEVANTIIFEGAASFVHIIALGMTVIMILHIRSKFTAVGRKEIITFFYIYMLLTMCSLVIDAGVVPPRSGPFPYFVAAQNGLASALCTSLLVNGFVGFQLYEDGTALSVWLLRLTSTAMFAISFLISLLTFKSWGGLSPTNTIGMFVVLYLLNAICIAVYLVMQLLLVLNTLEDRWPLGHIAFGLLVFICGQVILYAFSDTICENVQHYLDGLFFTTVCNLLAVMMVYKFWDYITKEDLEFSVGIKPNTWEVKEYPPDDDRRATTYQDTNSEYAGSMYHHRASAYNSHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV9</accession>
    <name>A0A5N6TSV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_156776</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSV9"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="433"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="572"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8149209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="621" mass="70581" checksum="AE1F1166DCB2EE1A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT61</accession>
    <name>A0A5N6TT61_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_125526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT61"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CDP-alcohol_PTase-I"/>
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    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="442" mass="48956" checksum="E41D745E6B5D92CE" modified="2020-04-22" version="1">MTTADGFGTQRVRRLSSLDACRADLYGGPNVVLPPKHLMASASTDAHETALAMEMAKQHLEDEVSSEEESPRVATPVHKGPFTTTDEFALAFDIDGVLIRGGEPIPAAVEAMKYINGANPYGIKIPYIFVTNGGGKTEEERCMDLSRQLDLDVSPGQFICGHTPMREMAERYNTVLVVGGVGEKCRIVAEGYGFKDVITPGDIIKTRHDTTPFRSLTEEEYENSRVRDFSTTNIEAIFVFADSRDWAGDQQIILDVLMSKNGRLGTRSETFNEGPPIFFSHNDVVWSTSHEHVRIGMGALRASLEALYKAVTGKELTTIAFGKPQMGTFEFATRLLRQWRKDTHGIDKPPNTVYFVGDTPESDIRGTNEFDQMSSTDWFSILVKTGVYQEGTIPRYPPKRVSDDVFGAVKFALERELSRRSNESAIADDVDSGIDSESARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTV6</accession>
    <name>A0A5N6TTV6_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTV6"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="45579" checksum="A7AE507F01E7F483" modified="2020-04-22" version="1">MAERSASRAGSVETTSKRAFSQGPGSRPQPEPETTPEPGTHRKQQSSVGGQTAMHPSATIEEQPEPTAEPTVMQPEDLADVVPTMRTRDGRLDHMESHIVALARGVTDLDNDRKRWQAQARAARSGSWVTKSSRVIREELAQLEGAVRGWAEKHSVPGMAAMTSGSPEGYQRIMERLKGHCTETDWTTLTEKLGKTTAHVPTLLTQALLARDLFGSIFANPFFAFGESQEPSVAHEPRSFSFLYASMLEVNKEEAHIWRSQMLRLLATPPPNSVHNAPLREQVETTTTRLAAEFLDGPVQPLLQTTNESGMVQRTQELHQLYQGAGELAVSLWTQRSFVKCYRIEELSVFRADHPIMSPHPLHHAEAGGGASDGQPVLLMVHPAVVAFGNEYAEHYDLCKVWAKAMMVVDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTV9</accession>
    <name>A0A5N6TTV9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_122966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTV9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="120" mass="13337" checksum="63E7A1A9DA93EDDF" modified="2020-04-22" version="1">MGPMDTQTMGLEKASRFLPHFPSFCLLFAGQHQLFFLFQSFLFSLCALSPMRQAACGSLGLTRQKPEASSTFGSTGGRGIFFLSRDSHDLLPYSFFQCPLHSINRTPFLNPRHEVAACPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUN4</accession>
    <name>A0A5N6TUN4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_122055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUN4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045564">
        <property type="entry name" value="DUF5910"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19287">
        <property type="entry name" value="DUF5910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024802633" evidence="1">
        <location>
            <begin position="32"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="261" mass="30369" checksum="9660312922A13DE6" modified="2020-04-22" version="1">MKRWKRRLSVMLSRFQELLIWTVFMVYTVSAQDPAIPNRPALGFERHGQENANPKAPTLRRLPTGIPSTHTLIGYLGVTPAHVEEYRATRGFEWYPREHPSDFILGKGLNLYPTVRRNWLDEGLLVCWVCADRNKFDMTHKAFVPDSFSVRTDLPEPYSNNGFIQFSIKEDRDRDGGKENRMAYYLNNYGGGPYQNTREVVRIANHPADESWFHVIPDALLHGNARDLDLRMNCTSERAATEDLEEIDYRDWTLYFSPWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUV0</accession>
    <name>A0A5N6TUV0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin-remodeling complex subunit Ies6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_119854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUV0"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="185" mass="20291" checksum="E7F398570582A4CD" modified="2020-04-22" version="1">MPPPTAAENESHQRLLNQLDIAHVARPFRNPHWKPSQRRNKNVKQLISESSRREASQMATQANSGATTPLPATTTTSTDGVQTPADGTNLAQAAQNLSTLVLEKNARATFPSGPAVTYTNIESAPSLHPSQQTRYCDITGLPAPYTDPKTRLRYHDREVFGVVRSLTQGVPESYLELRAAHVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV17</accession>
    <name>A0A5N6TV17_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_140279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV17"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="226" mass="23542" checksum="7954BBB633BBC078" modified="2020-04-22" version="1">MTESAPPPSAPNTAAMPSGPTTANQSSASNNNNSNGSSSGQGGANRGLPYYEKLRRELRDTLQRKRMMDKSMAALEDQIFRFEQSYLEETTAGNIIKGFDNYIKGSSSGAGGAGSLALSGGVGGARRKAQVTDADRVFSRSSASFLRDSTPSSVQTTPSHAPTPTSVNGSSGKPNGDSSAPGSVKGGPSSSKNKKKSNTNKDKNDDDDDAGDKPPSKRLKISYARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVL3</accession>
    <name>A0A5N6TVL3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_172252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742097">
        <property type="protein sequence ID" value="KAE8150314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVL3"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="652" mass="72405" checksum="7DD85F4D1B17AC47" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVN7</accession>
    <name>A0A5N6TVN7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_172177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVN7"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="256"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="589"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8150445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="832" mass="93299" checksum="E1FCE2EBB6629E74" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVQ4</accession>
    <name>A0A5N6TVQ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_112980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVQ4"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="26477" checksum="1E1559DAC3A00BEE" modified="2020-04-22" version="1">MTDQDNSYRPRSPDFSTFHSPIPPSVNHPPIYPLANPLAHRASYDASPFFTPQYHQPPPPPSGRTSQQYISPFTSLSIDPDMARRSSRIARATEVAPMPESTYVEPVLPEEPPKPEPVAAVEVKTKFPVARIKRIMQADEDVGKVAQVTPIAVSKALELFMISLVTKAAKEAKDRNSKRVTASHLKQAVAKDEVLDFLADIIAKVPDQPAGRKHDDDGSDQNEQPKRKRGGRRPKDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVT2</accession>
    <name>A0A5N6TVT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVT2"/>
    <dbReference type="OrthoDB" id="4501248at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="103030" checksum="3FD8DDDEEB4A98E9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX18</accession>
    <name>A0A5N6TX18_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_139357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX18"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF3">
        <property type="entry name" value="ORSELLINIC ACID_F9775 BIOSYNTHESIS CLUSTER PROTEIN D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="447" mass="51025" checksum="760C173F680873E1" modified="2020-04-22" version="1">MSAHEAGKLSRRPHRKSRLGCGNCKRRRVKCDEIQPACGNCKRHSIECDYQIDPNANKASNTPPERSASAGECPPKRGCTFFSSYQTNFKPPKRPHRRRKSMLKAIQHMSTKSVISPPLPTRPFDFTIIDMELFHYFLTTEDLGNPDRGSGQALDRVQLPRLGFSFPYVLRLLLTLSGFHRLRHRMDTPGQLCLLQQKDYQVTAERHYSLAVRELSAALPRLEKDNSYAIFTAAANIFICGFARGPQEGEYLAFREDNEKGFLNLFMGARMVATTCAMMFPSSAAGGQTESSQSSSEQSKTKDPTTTRRVISDYEAQLNQLQDLAFEMDDGLRPPVYSVIISRLHQLYDTIYSTHPPTHAELWPLVFAWLYQLPDPFLMGLQHRDPVSLVIFAHFAVLLNELSFSWLIRGWPEHILAGIHRHLDDYHRPFIQWPIAHILRESVNIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXH2</accession>
    <name>A0A5N6TXH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_129092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXH2"/>
    <dbReference type="OrthoDB" id="3177213at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYL1"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="35872" checksum="140A52D7AEBE9890" modified="2020-04-22" version="1">MVGLSEVRKSNSVLHSRDGDFVAVFVGGTSGIGEATAKELAKVVKKPTIHLVGRNEASGSRILEELKAANPEGTFHFIQSDVSLIKNVDQACSEIKQKEKAIDLLFLSTGHLATSKKDTSEGLENNHALRYYSRMRFVHNLLPLLSASKTPARVVTVLAGGQEGKIEEDNLDLQKSWSFMKAASYAATMNSLAVEHLAAQYPTISFAHVFPGVVRTPLMNTSFGSIAGSIVGFLSRPMSLSLQESGQRNVFISTSAAYPPAAPEDPTSIGVPLVDGLKATVASTGKVGGGSYILNYDGANNANEKLMNGYREQGFPKKVWDHTLAIFSKALGSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ60</accession>
    <name>A0A5N6TZ60_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_152540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ60"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="47106" checksum="5F3A2A494B1C715D" modified="2020-04-22" version="1">MSRGEQKYNWIDGAESLEKYRPGGYHPVMIGDILHGRYCIVDKLGFGGYSTIWLAQDSHLKQYVAIKVGIADALPHETKILRALSSPSVHPGRTSIPFPIDEFKLHGPNGTHPCYTMAPAQCNLREVSFSRLFPLEVARALSGSLILAIAYTHSQGYIHGDIHLRNVLVKLPSSIDQFSIEQLYQEYGEPETVTVTARDGKPLPPNVPAHAVIPLYLGKDAEEFSLSDARVILGDFGEAFSLDEVRRGEDCHTPLAMRPPEARFEPQAPLTYSADIWSLATTIWEILGMKAIFSSEFATADEVVSQQIDVLGSMPLSWWKCWEERSQFFDEYGRPKAGRYVWPRIEQAFEEGVQMYRRKSSRVCEFDGEETAAILELIKRMLAFRPEERPTAEEVLKSDWIVKWVLPDFNRSLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZB6</accession>
    <name>A0A5N6TZB6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_89304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZB6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="107" mass="12635" checksum="85CFBE12D4A7388B" modified="2020-04-22" version="1">MPLFRRSYPSSIRQTPMGPSARFRPICSPSCHLMIKRCWRCLALTQPCQRSIAQEICEAFYTLFLFLPLILFHHFLCWRIMWLFIVFNNVSVSAFVFASLCRRGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZM8</accession>
    <name>A0A5N6TZM8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_85283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZM8"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="338"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="445"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="799"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="921" mass="103082" checksum="305A5A2BD2CCC414" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZR8</accession>
    <name>A0A5N6TZR8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_85258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZR8"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="162" mass="17918" checksum="828B3133D2AD4284" modified="2020-04-22" version="1">MSTPSESAPLPNPRTGVSVILRDPRQEALCVLLGLRQGSHGAGSWAFPGGHIKHGETLEETCIREIKEETGLTITNVRFLTATNDIFVEERKHYTTNVMGADIVGDPEPKLMEPNKCAAWEYVPWEEIRAIAETGEGDRALFLCVENLFKQRKGFNPLAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0L4</accession>
    <name>A0A5N6U0L4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_151944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0L4"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8151899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="51480" checksum="732C927A22BAFF13" modified="2020-04-22" version="1">MDASNPTARPQRPMLQESLRSNSFLHDHQQYKPSVPVNSIGNVLGTSLEPGVGSLSLNPISPDPEKVTDSGITHSLFNHQANPLPTDTPQVVATIFYKSSDPIHPHLHPDSSSGVRSGVKLPSPTVPVGSAPTVDIEKIPREPPAPEPEPLDHLYGPFVSQLCLTNFLQILETLPTPYQRMNTSHRCLDQHEHPRVVEVTFSPPPNPDYLTFDDLRKHESIWRFEREWNVEVVLQKESVFRRHKRLVVFDMDSTLIQNEVIDEIARFIGVEKEVSEITERAMNGELDFSASLRERVGLLKGVPADVFEKLKSVITISPGARELCKALKNLGCKLAVLSGGFQPLAEWLAGELGIDYAFANHLEVDTATQTLTGKLVPTYPIVDASQKRTLLRSIAADNNIPIAQTAAVGDGANDLLMLHAAGLGVAWRAKSKVQLEAPTRLNGETMTDILYLLGLSRGDVRELTVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0M1</accession>
    <name>A0A5N6U0M1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_151461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0M1"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="262" mass="28654" checksum="67CF8CEC46A126EE" modified="2020-04-22" version="1">MATRRGVGLGAFANRTQASQFFANHGANLRSTHLSSLQTQLSVFQSLLHTFALEHSSTIKSNPTFRAEFARICNTIGVDPLAASNVKGKNARRGPGESGSIWTQIMGGDMNDFYFEVAVRVVELCRETRSENGGLLGVEECRKRVGKGKAIGSGLEVTDDDVLRAVKSLEPLGSGFSIVRVGSKQYIRSIPKELNTDQATVLEVIQISGYVSLSMLQLNLNWEKARAQTVIDDLLADGLVWLDAQGKEYEYWSPQNLLDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0W4</accession>
    <name>A0A5N6U0W4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_152111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0W4"/>
    <dbReference type="OrthoDB" id="3365636at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="749" mass="83640" checksum="8C09C8A4155F6564" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0Z5</accession>
    <name>A0A5N6U0Z5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0Z5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="18752" checksum="7B18E5DFAE8658B0" modified="2020-04-22" version="1">MAGSNRLRRLKHHIKDRLRSNRSTPETRSRSASPNGQKDEDPTTQTSSIPDAIFGLTKAVSAVGLGQDLPDCTTDKNDLDDLETKLKDDSVQNSLWQEAFQRIERDHPGPVHEFQELLLETDTAWPTNEANPVDASEISSEEQQQPLQKLVQDRIVAVEDARLKLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U101</accession>
    <name>A0A5N6U101_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_128077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U101"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038816">
        <property type="entry name" value="Stationary_phase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342:SF1">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="724" mass="79867" checksum="AA678651772E3B6C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1Z1</accession>
    <name>A0A5N6U1Z1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane peroxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_150828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1Z1"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
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            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U297</accession>
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        </submittedName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        </location>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_150425</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Chovatia M."/>
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            <strain evidence="8 9">IBT 18842</strain>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="555" mass="61151" checksum="27DB9EB87660D75E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2S2</accession>
    <name>A0A5N6U2S2_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2S2"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="YjgF/YER057c/UK114"/>
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        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="136" mass="14971" checksum="5C857AC3F7653E2A" modified="2020-04-22" version="1">MSSLTYINEDGAGQKHSDLCHYSQAVLLPGNIVKCSGQGGWTSSGDLNADDVRGQVDLAFQNVDRVLQAAGLKGWEDVYLVRSYHVDMGSSYDYVVEKLKTRIPGHRPVWTAIAVPCLAFPPMRIEIEVEAFNSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U317</accession>
    <name>A0A5N6U317_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_137495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U317"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="221" mass="24490" checksum="76C11AD291064460" modified="2020-04-22" version="1">MTSISHDDIQMRQFEETGDSVPERSKNAEGTGTGHEIFSTEGEEETPDYPNGLKFWLIILPLRTLLAIGGLDTNIVATAVPTSITDDFYTVANFMFGKLYKLISIKRRTVLPKEDTSLGLSIVLPAQYFGPAVFVAIAQVIFMNKLAINFSNVVPGLNPETIESYGLFEIVGHTPPDKRKEVFARVGNSLTETWYLTVGLTCATMLSSLFMEWRSAKPKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U360</accession>
    <name>A0A5N6U360_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_169727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U360"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="550" mass="58920" checksum="04666C7A0DF8364B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3C0</accession>
    <name>A0A5N6U3C0_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3C0"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="260" mass="28065" checksum="42FA16768BA6552C" modified="2020-04-22" version="1">MSNETARAHSSMTLSNESSAIGETAMSPRFGLSCSEGRKEGILGIPGLMIMDNNDMYTETSFADILSESAEICSKTRALMLENLRLSRHSTDRADSHHPTSGETTPSIIGSESDYVPNALAEDARNLSPPKVGNVEKGTSAGWLSALHIAAQKGHVGIVRVLLQQDIDCDEVDSDGLTPLVHATIKGHKDVVNMLLLHGARINSTDKEGNSVLHWAVRRERGELNSAGMTPLHLAAEIGFEEGVQMLLDYGANIHSRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3H7</accession>
    <name>A0A5N6U3H7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_149839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3H7"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="148"/>
        </location>
    </feature>
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            <end position="182"/>
        </location>
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            <end position="214"/>
        </location>
    </feature>
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            <end position="304"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="475" mass="51580" checksum="E49DB508A5AE4CFE" modified="2020-04-22" version="1">MGRNPVNILGGFQSASDRGDGNSSAWYRVYTYPWFQILLISFICFCCPGMYNALTGLGGSGQVDPTVAANANVALLSAMAGTALFVVGPIFDRIGPRACLLIGGWTYPLYSGSLLCFNATANGAFVIASGAILGVGASFLWVAQGAIMTTYVPESQKGRAIAAFWIIFNLGGGVGSLASFGMNYHSTTGTVSDGTYIALLIIMAVGWLLGVLICPPRSVRIADMQASPEVEKSWLKVAKLTVKTVCDWRVLSMLPLFFCANVFYSYQQNIVNGMTFNIRSRSLNGALYWIAQMLGGLIMGVLLDTPGLNRQWRARVNWLFLFVTGMAIWGGGYAFQLWYDRRAAQGKKQDIDFTDSRQSVGPIFLYIFYGMYDAFWQSFCYWLMGAQSNSPAVAAILVGSYKTFQSVGGAMAWRLGAMGKSAMLQFAVDWGLCMGSLVLAIPAVLAVTLTNTDENSLDEVDLKYTQPESGEDHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3T7</accession>
    <name>A0A5N6U3T7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_137127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3T7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="112" mass="12250" checksum="76716E476ECE48A7" modified="2020-04-22" version="1">MKITCPKEGANIDTRREWQVCIEDITGDNNPVSIWLTHRTTDPERCEQIVASYTFSAQELEDQKATVTINGGVVVSSPSGANYRVALAAVGLNPTQCPGIWCETLDISIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4G7</accession>
    <name>A0A5N6U4G7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_168912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A5N6U5D6"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF35">
        <property type="entry name" value="ACYL-COA THIOESTERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="175"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="300" mass="33104" checksum="D264780474FB3011" modified="2020-04-22" version="1">MAVTLNQQIAVEPSGPGQYQSVLNPTRMGTLASYVYGGNTLAVAVNAAYQTIESPYHLYSITGHFIRAATTERRFICAVETTRSTRTFQTRFIRVSQKADDGSIQLCLIASADFHIEEPRSMVTYSTRPKTSMPFTLQDNQPPSNPVKELGLYKHIEPFLEKHTIAAASENQLATKGGSSTAPEKFSAERFRIRGPLNNEADQVSALAFYMDKGLAYIPANHSGYQLTDASACASLDFSLRLFTHEIDLRKWHLTEATTSVAGNARAFSEGRVWDGNGRLLASMTQQTLLRPKAGFISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5D8</accession>
    <name>A0A5N6U5D8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_148553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5D8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="72" mass="8110" checksum="D0C1EE3196CF30E6" modified="2020-04-22" version="1">MAPRKPRCNFKECKEAAQRIVGDCSFCSGHYCSKHRMLEAHACTGLEDCKKESHARNADKLNSERTQVIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5J6</accession>
    <name>A0A5N6U5J6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_148689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5J6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="528" mass="59839" checksum="4AAED026A05A2748" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5W5</accession>
    <name>A0A5N6U5W5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_136366</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5W5"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024869924" description="Crh-like protein" evidence="20">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8153996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="379" mass="39869" checksum="3372B41555C2C1F1" modified="2020-04-22" version="1">MNLSLYLLVLTLACFPGPILVCAQTYTSCNPLKKTCPLDPAFGASQSFDFTKEISKGWKPVGTVAHDKDGMALAVAKKLDGPLVQSDFYIMFGRVEFTLRAAPGTGIVSSAVLQSDCLDEIDWEWLGGDNAQAQTNYFGKGDLTTYDRGAYHPDPGNHDAFKTYTIDWDSSRILWQINGNTVRTLEEKNAKGQYPQTPCFIKVGSWPGGDPDGAPGTIAWAGGLTDYSKGPYTMHVKTIKVTDYSTGSTYEYTDKSGSWKSIKSNGGSIHGLNPGNAVPSSSPVTSKASKVNTVATTSSACSTSTKSSVAALPSTSVKASSSAVAVSATSAAKSSPTMRPVNSTAPAPIRSSGASGNGLKGYFMTSVLLLAGYVLGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U678</accession>
    <name>A0A5N6U678_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_168625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U678"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="69"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8153641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="327" mass="38058" checksum="A293B801CE043AD5" modified="2020-04-22" version="1">MNLNKSFPYIVKETLEIQSHIPEPPISKREFLRQCASKKQDESRSPAQLCFQNPPLPGSDSGNFVSIKIIQALHVGYEKRSQILRVRREDSSNLRCPPTNQDIIAKIYDPLYHDYDISDDDPFRGADYDYTHECAAYTHLSDLQGTVIPKFFGSYTLKLRFGDSFRLVRLVLLDWINGPSMNQLKPTDFSRQERQEIMKQIVDAESSLYTKNVSHEDLRPQNVVLDRSSSKGLRVVIIDLGKSVIGRSRNPSDSQLENRYLPGVAISPLLRWNVVFRRHGHFQDWIDWPWQSWLEEQYKDTEATITEEQRAVWKIYDWMLESKPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6B9</accession>
    <name>A0A5N6U6B9_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_126809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6B9"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="35966" checksum="443670EFD6D4DEBE" modified="2020-04-22" version="1">MKCGFRLAIFACLILLFPLYLLKVHLDDLFSQYRAGAYLIDWLNAKKSHHEGLSHYHGKLGDKVIVMAKLEEEPTEWVRQELPDWQRAIYIVNPSRQTKADEQKLKTALNKGHESMAYLTYLIDNYDNLPSTIAFLHAHRSGFFMAWHVDAPLHDNVAAMRALQLDFIQQNGYVNLRCNWNPGCKADHRVNGHVTEQVWQEVFEGTSTPPLNSTTSPIIESEAQSRQTQRFLQAPQFVGAACCAQFAVSREQVLQRPREDYIKFRQWVIDTEKDDASSGRVMEYLWHIIFGRESVYCPDEEVCYCQVYGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6X8</accession>
    <name>A0A5N6U6X8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_109087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6X8"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="252"/>
        </location>
    </feature>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="529" mass="57494" checksum="6372DC3FA079CC39" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U725</accession>
    <name>A0A5N6U725_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U725"/>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="32603" checksum="31C45986A138C940" modified="2020-04-22" version="1">MSLTYSDNLAPRPATDVFTAEDTCIDRRKCHRTVPMKVLALGVGRTGTASLRIALERLGYLKCYHMMSASVENPPDCLMWHDALLAKYDGVGEFGRKEWDQLLGECQAVCDWPACAFAKELIEAYPNAKVILTTREVDSWHASVMKTVWWRVTDPEHSFVSNFSWAASMYYPMLNKFFQTFFRGDFPNKGKQVYLDHVEEVRSLVPPERLLEYKISDGWGPLCEFLGEEVPDTAFPRGNDMADFFQRCRTRNRRQMMNAALQAFTMGGALLATGLAATMAFKRFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U754</accession>
    <name>A0A5N6U754_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U754"/>
    <dbReference type="OrthoDB" id="5422905at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="152" mass="17080" checksum="ED8A98AADFDC78C0" modified="2020-04-22" version="1">MPPRAFISGPLSTGPSQTYFKTHYIPKINTAIAKGHHFVIGPIPSGVDKEALEYLLSYPVPPAHITIFVTSTEDRMWGDMFRARGVRVHVVEGWEVTSGDRDAAMTAASVYDILRWRTEEEARAFYGSLYREGHVTNTERNWLRRVGEGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7I6</accession>
    <name>A0A5N6U7I6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7I6"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38139" checksum="F7BE0DA17FB37A02" modified="2020-04-22" version="1">MTEKSTSMPPFPKDNELVDLLSINDDSHGPQALCGGYTGYSSTSIPGYPLQDATDTKQVQEFLSSHLLTPRLDDLHPVLWMVGTRKSDHVYSLHKQIVRGHEIVYAEDPGLHLVWYYDKIYIKPIPPYLLNHAFWNTHLYGNSEPTVKLRQAALGFMRTYVWLIQSEYDFHLAQTKMLVPGNTTFLRFMHFIDSFRHIQDTEVNPRYRQYGQLRLSRLNLWSKLYQGRMFYYKVDAQYAAYFARFVPLFLFIFGSVSVALSGMSVVLAVDNGFEAKPDLVFARVSNWFSVACMVVIAAVLVFFPVMQVAFLLRELVYVVWNWNRKGFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7R6</accession>
    <name>A0A5N6U7R6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_93853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7R6"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="358" mass="37832" checksum="3BE2E5B62D9CB2C5" modified="2020-04-22" version="1">MAAGTTPQDNQTMKALVYAGPNKYEVQDRPMPVIQSPTDAVIKMLHTTICGTDLHILKGDVPTIPHGRVLGHEGVGTIVSTGSAVTDLHTGDTVLVAAITACKVCRACMKGLESHCATGGWVLGNKVDGTQAEYVRIPHAASSLHKIPDGLDLKACVGLSDALPTGMECGTVSAQVQPGSTVAIIGGGPVGLAAMLTAKLYTPSLIVMIDLDEKRLEHARRLGADRTVNSGKPDAVETLDAITEGQGFDCVIEAVGIPKTFELCQKLVAAGGSIANLGVHGQQASLDLHKLWDHNISIKMQLLNGVSIPTLLRLYQSGHLKPSDLFTHDYPFSEVGKAYNSFQMAAQEGALKVRIDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U815</accession>
    <name>A0A5N6U815_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_126373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U815"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="312" mass="35097" checksum="6471CE81E5FA1196" modified="2020-04-22" version="1">MTELPHSTIKTRFLIISDTHSRDSLPSLNEPADVAIHCGDLTKGSQLEEFKAAINLLKQINVPIKLVIAGNHDFTLDPPAFQNKIREARRLQDIDPIHIEKVYGYCGQVRELFDHVDVKEKSGIQLLDQGTHYLTLKNGASLTVYASPYTPSFGEWGFQYSAHEGHEFEIGNVDLVMTHGPPRGILDNDESGRRAGCEYLFRSIAQSRPRMHCFGHIHRSWGAKMITWREVISEKPSHLTDIDNGQSTVIKKLSNIKATGHQPSYRTSHCADDVNPLQYGRHTLFVNAAIEGSDDFPTHPAWLVDLDLQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8B0</accession>
    <name>A0A5N6U8B0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_171823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8B0"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="50086" checksum="D3C5AD756A3BE3DB" modified="2020-04-22" version="1">MIQKHKRTKSFFQGCEPHITHMRNEPVLKVEDFRSFHSEAWKLGRRMRDDMPGLHSIMVLRLQVRGGAKLVAKTFFGREYFESKKQLDPFLDEARAYEHITRHCAPSKLSYFPRYMGTILNLTRREYPTSYPLRPQAIVLERVHPNIQSRRILGERQRPKHALFDDFGTKISEMPLSPFEQDWYISLTIDRLQSVAALHDMGIIHRDISDEHFRLPHDFHDTVLYDFSHSYIINIPWPYIRRPVPFAELIQKEQHDVLGSVFSRAQTADFRTYMATSLDLDPAMIMNACSQDLEDTEKLELIALQTRHRPDAFTHPSLASIFPFLESIRPNHTPTWHIARARLLQVYDSVWFVHVPNSEQVHLVSFSGAQNPELDVDNTAQEVSFLLLLVPRSWDMQSHKRRLCTCAQLVANKECGSIILKEEFDELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8H3</accession>
    <name>A0A5N6U8H3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_126130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8H3"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="514" mass="57094" checksum="B2AD012A7D8DEC9F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U992</accession>
    <name>A0A5N6U992_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_135234</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="784" mass="85683" checksum="2EDA2304F8DD5262" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9H3</accession>
    <name>A0A5N6U9H3_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146378</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024808570" evidence="7">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="518" mass="58102" checksum="9F6D066E35E0D528" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCJ6</accession>
    <name>A0A5N6TCJ6_ASPAV</name>
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        <submittedName>
            <fullName evidence="15">PINIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_167641</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="UniPathway" id="UPA00886"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIZ zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINIT"/>
    </dbReference>
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        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
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        <property type="entry name" value="SAP_dom"/>
    </dbReference>
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        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF100">
        <property type="entry name" value="LIGASE SIZA, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G05240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="108"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="442"/>
        </location>
    </feature>
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        <location>
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            <end position="452"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8144108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="529" mass="58091" checksum="3A594D11A6582B20" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD93</accession>
    <name>A0A5N6TD93_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_99092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742568">
        <property type="protein sequence ID" value="KAE8144323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="374" mass="39994" checksum="678BE27639F3D4D8" modified="2020-04-22" version="1">MHSSSTTPIPLWLDCDPGHDDAFAILLAAHHPSLRLLGITTVHGNASLENTTNNATRILEAIGRPEVPVYPGRGKPFCRPAIYAPNIHGESGIDGTDLLPKATVPPVTDKNPILAMRDAILAEPKGEPWVIATGALTNVALLLATFPEVVAHIKGLSIMGGGVGEGFTDAPMSRLAGQETRIGNVTPLAEFNIYCDPEASQSIFINPVLAAKTTLITLDLTHQAFASLAVQSRVLHGSDDTSVLPTTLRQMLHDLLLFFASTYEAVFGLKNGPPLHDPLAVAVILSTLNPEYAKQHPNEALKFDDRNGERFDVDVATDGLHGTDVELVGELGRSRVVPGNAGVAIPRGVDLESFWNMILDCIKRADDCNAARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDA8</accession>
    <name>A0A5N6TDA8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase substrate phospho protein PP28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_97038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742545">
        <property type="protein sequence ID" value="KAE8144378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDA8"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="128"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="234" mass="26201" checksum="667F1814EABD1C8B" modified="2020-04-22" version="1">MAPRGRGKFFKPSRGGGKHYSRDVQPTDKHGNPVGLWREPDDGSVSSSQEEEESGSEEESSGEESAKAESGSKAESEMTREERRAAAKARKQAAIAKRGQVQPGDLPPSDSEIEDDKDEAEGNDLPANPNHTTKSREQLDRPTSDVDLSQLSRREREAIEAQQERERYMKLHAEGKTEEARADLARLAIIRERREAERLRKEAEKEEKVEMAKQRAAEVQAKMNAKRKGGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDE5</accession>
    <name>A0A5N6TDE5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_134769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742568">
        <property type="protein sequence ID" value="KAE8144322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDE5"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000003">
        <property type="entry name" value="D-galactonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000013">
        <property type="entry name" value="Mandelate racemase/muconate lactonizing enzyme family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="383" mass="42634" checksum="CB0D35C6E6DAA7A1" modified="2020-04-22" version="1">MAKIKSIEYFRVLPRWLFVKIVDEDGNHGWGESTLEGHTEAVEGTLNALCKRFQGYEADDIEHIWQMAWRLGFYRGGPVFMSALSGIDIALWDLKGRRLGVPIHQLIGGKVRNKLSVYAWIGGDRPGDVEAAGRARLEQGFKAIKMNATEDVNWLDSPRALESSVERLKAVKAIGLDAALDFHGRLHKPMAKQLAKALEPHKPLFLEEPLLSEHPEGIKQLSDQVSCPIALGERLYSRWDVKRFLEDASVDVLQPDISHCGGISEMRRIASMAETYDVAIAPHCPLGPIALAACMQVDLATPNFVIQEMSLGIHYNTEAGDYDITSYVKDASIFNVKDGYVDALTAPGLGIEVDEEVVRRVAQTTEPWQPKEFFGPDGGIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEU8</accession>
    <name>A0A5N6TEU8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_134473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742461">
        <property type="protein sequence ID" value="KAE8144659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEU8"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="51992" checksum="04DC2C0EB995D4DF" modified="2020-04-22" version="1">MEQSLSLISAQVQFMEDRLALVHIPLDIYPYFLGPILQVLFHEVPPISPSHGLHGDGSPNADYTNSLPAFLNVSITPVECSIMCPRQLADRHFAPLIERFVKEHCTTRRRPILSREDFIAMQVYGEGLEAGQRVLELTSPLAMAGISIFFISTYFSDYIIVPLRSKTQVIEALEKRGFQFEMSTDTFINNNQFNTGLSPVSPRPSSSLGSPPATPPPSSIEELQTRTFSSLRKNCIVPSVDNSLRLVQCAVHHRDSSETRSISILRDALTLALVVDKPRFLSLTMTAADPAASLLLEKRLLPRFSSDPTMSGEADDESSLLLGSKEEILVPIMLDLRKLPMEATGIVCGVAGRLADATHGRDDVTDGSSTILSHSYSGAPSPFESTMDRFLSTSVGSGGPVRPPASGFGRKLTNGNAPTHHLQPDWDTYVEAVEISFLSTARAGTIIVGEHELQRAVGALEAESHDPDTFPLELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEW6</accession>
    <name>A0A5N6TEW6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="7">SDH assembly factor 2</shortName>
            <shortName evidence="7">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_134237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742413">
        <property type="protein sequence ID" value="KAE8144923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEW6"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024799503" description="Succinate dehydrogenase assembly factor 2, mitochondrial" evidence="11">
        <location>
            <begin position="26"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="535"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="620"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="764"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="792" mass="88376" checksum="18A808F46FFE69C2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF04</accession>
    <name>A0A5N6TF04_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_165681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742409">
        <property type="protein sequence ID" value="KAE8144953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF04"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF6">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29773" checksum="B052626740915045" modified="2020-04-22" version="1">MLYTLGLFAVQPVRFIEKYEWRALTDLEKCAIGTFWKSLGDSLAISYEALPSGKTGFRDGIHWLEEVMAWSDAYEITHMVPNITNRQTADQTTALLLYMVPKPLQNIGLQLVSFMMDDRLRRSMYYEPPSALYAAVFSFLLSARRFVLRYLMPPRPYCLRFSSFTENKDKNGRLYITQWDGAPYYVKPSFRNRWGPIAWLTWAMGRPLPGDDGDKYFPMGYDTLEVGPRHFQGKGRATTEKYVEQFESSRTGGCPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFQ7</accession>
    <name>A0A5N6TFQ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_165751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742412">
        <property type="protein sequence ID" value="KAE8144931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFQ7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="52" mass="5786" checksum="CDB7162A003A3EEC" modified="2020-04-22" version="1">MVLSGTAAFGNENADHRRAGTLFQAFQVPDLSQFLDVWLVMCAVVLRCWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFY7</accession>
    <name>A0A5N6TFY7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_164995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742363">
        <property type="protein sequence ID" value="KAE8145288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFY7"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="427" mass="47568" checksum="7B86C81773D35022" modified="2020-04-22" version="1">MMLPLLQPFTQSLPQHCEPSSPFLAALSSYLHTCIPTPLAFISSILGTLSIVSWLFAQLPQIYKNIQLQSTSGLSIFFLVEWCLGDASNLIGALLTRQATWQVIIASYYVLVDVTLVFQFFWYTHIKGRRSDYDSLSQLHNDNGTAGILEGVSFSENDTTSNTPSESMHTSDAKDVKGRKEPIFGSFNGQSPSYSNEKLSTSRRSMTRTSSGPRLPIASTRTILLTSMLCAVVANAAPTEPVPQPEPSLFTLEFVGRIASWMSTVLYLFSRPPQLYKNYCRKSTSGLSPLLFMAAFGGNFFYSASLLTNPNAWYDFPPYGGGGWADGNGNNRVEWVGRGIPFFLGAFGVLFFDGFMGVQFLMYGTRDDESVIEIEDPKHGQSRWMRVRGWMRGWIPSVSPKREVHRQVASPERQTLLGVDRDRYGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFY9</accession>
    <name>A0A5N6TFY9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742380">
        <property type="protein sequence ID" value="KAE8145150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFY9"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="171" mass="18070" checksum="7DAB9EF7E39C984B" modified="2020-04-22" version="1">MSEFPPSSLRPLIQEVFELLKTQKETVSVAETAAGGLISSCLLSTPGASSIYKGGLTVYTLESRIAFAGWTQAHVENYIGPTPAIVAQLADNVRHTLGSTYAVSESGTAGPTGGTTRTRTPGYVAVAVSTTHGTYMREIETGSDNREKNMVTFATEALKLLRDVLTGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH39</accession>
    <name>A0A5N6TH39_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tetratricopeptide repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742320">
        <property type="protein sequence ID" value="KAE8145695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH39"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30491" checksum="E28B33840BEAFC8A" modified="2020-04-22" version="1">MTVDIPKERVDKAASDSEDEDVFHDARFPAEEEAQLLEESQSIKSEANKLFTVACYDQAISCYDRALASCPNYLDYEVAVLRSNMAACYLKLEDWKASVDSATSCLDRLEKIIPSADESDKPKNRKQDSGSADAVVEISGDNEEAEQEELKRLHKNDERKNDILRVRAKALMRRARAKSQLGGWGNLQGAEEDYKLLAAMENLPPDDKCIVQKALRELPARINQAKENEMAEMMGKLKDLGNGILKPFGLSTDNFKFTQDPKTGGYNLNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH74</accession>
    <name>A0A5N6TH74_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_133593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742324">
        <property type="protein sequence ID" value="KAE8145657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH74"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="279" mass="30102" checksum="4790EF227FE7A067" modified="2020-04-22" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSSPLIDPPSLSKVSLITPDIGMVYAGMGPDYRVLVDKARKVSHTGYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLIAGWDEGVEPESGEAPKDDSEDEPKKATGKTGGILKGGPSLYQVDPSGSYYPWKATAIGKHATSAKTFLEKRYTEGLELEDAIHIALLTLKETIEGEMNGDTIEIGIVGPPADHLLGFEGVEGAQGPRFRKLTKEEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THD9</accession>
    <name>A0A5N6THD9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_69228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742335">
        <property type="protein sequence ID" value="KAE8145549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THD9"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="218" mass="24870" checksum="05027D72982FBC62" modified="2020-04-22" version="1">MDAHNIFAVHSILQLIYHRNKNQHRKTKWWKWLSILKRNTWNLARSLEHVLSLGGIKSSPETYKQYLVTYIFPNCYQAFSMVVADGQFSTLGTVLLGTLARLTKAMGMNKELQTVVQPRKLHVVAPSHAKATEAVDIGEVLARNKESNSSELCTASRLATGHNLKAISKKPKGVMNISAGKENNNKQEHKEHKERKKMKERRKERKKDAIDDLFKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THH5</accession>
    <name>A0A5N6THH5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_62070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="ML742313">
        <property type="protein sequence ID" value="KAE8145782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THH5"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="709"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8145782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="796" mass="88448" checksum="C1C9B281298B4BDE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THM2</accession>
    <name>A0A5N6THM2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nitrogen regulatory protein areA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_61292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742310">
        <property type="protein sequence ID" value="KAE8145817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THM2"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011420">
        <property type="entry name" value="AreA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07573">
        <property type="entry name" value="AreA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="654"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="310"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="707"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8145817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="861" mass="92685" checksum="34F1802DDD308BA0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI74</accession>
    <name>A0A5N6TI74_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_163822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742312">
        <property type="protein sequence ID" value="KAE8145799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI74"/>
    <dbReference type="OrthoDB" id="5304883at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="249" mass="27532" checksum="3D8AFF2A00F9A661" modified="2020-04-22" version="1">MTECHGEGRGACDLSPQAQSCATEVGNGELTGLNQISPDAALDLLCIYVELLATQSLFEPGVQVVTASLPKYKAESESISSGEVTPTNTEIHCCPVGYDKASRDRVQLGILSRRFLSKRVPSITIKEYLMRLHRYCPMSTAVYLATCVYLDRMVTVEKIISINPRNVHRLVLAGLRVAMKTLEDLSYSHSRVAKVGGVAEHELSKLEISFCFLADFELRIDAHMLTSQAKCLRRNMNMNIGLHADDTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIB5</accession>
    <name>A0A5N6TIB5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_163189</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="ML742287">
        <property type="protein sequence ID" value="KAE8146093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIB5"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="145"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8146093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="56369" checksum="1BAB1F26D356A207" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIK0</accession>
    <name>A0A5N6TIK0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_55066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10009287at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="169" mass="19060" checksum="80D16467A34AD528" modified="2020-04-22" version="1">MATFQDRAQHAIAQLDKELSKYPVLNNLERQTSVPKVYVILGLVGIYTFLVFFNIAGEFLVNLAGFIIPGYYSLNALFTAGKADDTQWLTYWVVYAFFTVIESAVYAPYWFPFYYIFKFGLVLWMALPQTNGAQVVFHSFLQPVFARFFAGGSTSANLRAQADAATKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ15</accession>
    <name>A0A5N6TJ15_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_54439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742277">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1518"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1552"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1561" mass="172233" checksum="A61275A0D31049E2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ31</accession>
    <name>A0A5N6TJ31_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sigma-70 region 2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742268">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4158087at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73412" checksum="9DFCAB84B8D2D2BA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJI1</accession>
    <name>A0A5N6TJI1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_162428</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="ML742262">
        <property type="protein sequence ID" value="KAE8146430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJI1"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8146430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="605" mass="66446" checksum="ADA9C84F2B41994D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJK3</accession>
    <name>A0A5N6TJK3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_49041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742256">
        <property type="protein sequence ID" value="KAE8146544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4507572at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
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        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="456"/>
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    </feature>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60357" checksum="4CB2292DA3032046" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK59</accession>
    <name>A0A5N6TK59_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742258">
        <property type="protein sequence ID" value="KAE8146499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK59"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="124"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="53619" checksum="8C0D05D356B177DD" modified="2020-04-22" version="1">MCSFMTPSPKLGESISKWGYTFTWTDKHPSKEQIEPLRQEYDTLGAIALQRIQSIRSSMLEESKVKGTSPPTNDHYTILLNHHTEDEILTQFWDECHAVPEWVNWEQLERGQRFFFRYAIANIVGFALQGFVAENSAAPGVVEVLVRTGSFSTRMLLKRLLETFQWLIQVTHDLAAIRPGGEGHVATIRVRLLHASVRQRILRLCQAKPDYFNIDRYGIPVNTLDSIHSITTFSCNPMWLQLPKFGIKPSSGEIEDYIALFRYLAYLLGTPTSYFKTIEDSKRTMESMLVYELLTTETSRVVAYNFVECVAHLPAPVHVSRKFIEAGSRWINGGELCDELELGRPGYFYYVAFAGYCMFVFGLALLQQLIPRIDTLVIKLFRQLLHREIVQRERSRFDFKHVPHTGKTIGKERYDPNAAKACKYPPYLNYTFYDITDIGYFELVCFAVTVFVVLLVGSVIGIWLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKZ3</accession>
    <name>A0A5N6TKZ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_161228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742230">
        <property type="protein sequence ID" value="KAE8147018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKZ3"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="839" mass="94833" checksum="1710CB4DD2827153" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM61</accession>
    <name>A0A5N6TM61_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM61"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="116" mass="12934" checksum="5DE44C6E1B1C691A" modified="2020-04-22" version="1">MGVQAPNTGLNMLVSQGWNSGPDTRGSLDILWTCLSTLALCVWTAIHPNIPLSYTFWPTFLERVGLMVIAIMFPEVILTSAWGQEIRAENLLVEVNRLLGHSGRGLEVCCRIYDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM71</accession>
    <name>A0A5N6TM71_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_33129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM71"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="360" mass="41513" checksum="5CB49C1163E01061" modified="2020-04-22" version="1">MPSTYKKDKPWDTDDIDKWKVEPFKADDNVAGSFAEESSFVTLFPKYREVYLKEAWPVVTRALEKHGIACTLDLVEGSMTVKTTRKTFDPAAILSARDLIKLLARSVPVQQALKILDDDVACDIIKIRNQVRNKERFVKRRQRILGPQGSTLKALELLTSTYILVQGNTVAAMGPFKGLKEVRRVIDDCMANIHPIYHIKELMIKRELAKDPTLVNESWDRFLPNFKKRTLSKRRTPFKVTDKTKKVYTPFPPAPEKSKVDLQIESGEYFLSKEAKDRAHKEEVMEKQRQKREEKMQERAKSFVPPEELEAQEKKKEKKEKKKRKRDAEAEADVDGSEKKEKKKKKKSKSKESAASDGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM88</accession>
    <name>A0A5N6TM88_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_142715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742206">
        <property type="protein sequence ID" value="KAE8147466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM88"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="222" mass="24933" checksum="49A69FBDF8A90165" modified="2020-04-22" version="1">MNKELLNNDNPPLQDKGQSIKEVYPDLYYEDDSKLNQPTKVRFFIDVPRKATNFEILTQSISTFSDMKEKGLLCNPASPVEKGLKRISYHILAGCHHGGLLLVDNFINVLIRSRKHVGKCKDDELPLPLRSGDGKVRALMSEITWEKKGEEVVISDVDADDVDYMGYMDEMGGMGDMVDMNCIDDKNDMGGTRDMGDMRETDVRDALELTGGVEAKPWSPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMN1</accession>
    <name>A0A5N6TMN1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_160039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742200">
        <property type="protein sequence ID" value="KAE8147594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMN1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000115">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="9">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="54" mass="6155" checksum="F1825C07B28B2A4F" modified="2020-04-22" version="1">MIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMY3</accession>
    <name>A0A5N6TMY3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_29065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMY3"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="348" mass="36646" checksum="649F3D41C849A09E" modified="2020-04-22" version="1">MSLQTPLCSLLKIQHPILLAGMARASGAPLAAAVSNAGGLGTIGGLGYTPKQLSEMLTELKSLLRDPSLPFGVDLALPQVGGGARATNHDYTHGQLDQLIDVVIAHGAKLFVSAVGVPPAHIIRRLHDAGILIMNMVGAPRHAEKALKMGVDIVCAQGGEGGGHTGDIPFSVLVPAVVDVARAYKSPLTGQPALVVAAGGINDGRSLAASLMLGAVGVWVGTRFVASEESSASRLHKEAVVGAQYGETKRTIVISGRPLRMLPNEYVKEWEKRPQEIARLTAQGVVPMEHDLENDKEDVELPYLMGDVSAIIKEIQPADVIVREMVQQAVEVLRKGGSYIQVGSANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNH3</accession>
    <name>A0A5N6TNH3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_159305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNH3"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="371" mass="40592" checksum="16F9B7F766A3A7E2" modified="2020-04-22" version="1">MPTGAVLVAGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALRRIELISGKKAEFAQIDVTDEAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYYVNVYGTLNLLRSMTRHNVYNIVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGNTKFAVENAITDVINAQRNNALKAGNEAEAKKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDYASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGKGSTVYEMIRAFSDAVGRDLPYEVAPRRAGDVLNLTANPTRANTELGWKAERTLEQACEDLWRWTENNPQGYRQEPPAALLEQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNK5</accession>
    <name>A0A5N6TNK5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742183">
        <property type="protein sequence ID" value="KAE8147953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNK5"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="244"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="418" mass="46750" checksum="A9C85003AABC16BD" modified="2020-04-22" version="1">MSAFGRRSNEGHGSYIMNQQVALPAPYTQGDGHEFGVNDAGSYHFPSQPFSSYASQFSSPYAHPGISPHGQHISPHHSPGHSVPSAPDHGSLIHHHHHHQSVQYIPHTRYLQSPRYMPFREALGETEIESQDSRHESTMMSEPVIPPLDGFPNVREFDQLMKSYVDDLSVKKQDKALIHAKRARNIRAVLLDPKDTTVESAQFRCQYALVTELITPHADTLMTTKCTKMICHEGKPVAIREKLFKILTRAHQQCQHGGRDKTSAQVRQIYSWVPKELISRFVKICPTCQVRRGGSRLTPPNSRRSSPRLEIVSRSPKLPSPPMSRRDSSLNIHLPLDRPHPDYMGQFNGHGSWAENSKSIHPRSNLNPGHPFTKASNSLPSSSPTVVDPLHDLSVPSSQVNYDSGYASTHGPSGHRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNS0</accession>
    <name>A0A5N6TNS0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_159157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML742180">
        <property type="protein sequence ID" value="KAE8147998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNS0"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000038">
        <property type="entry name" value="DEAH-box RNA helicase (Dhr1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="385"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="585"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8147998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134949" checksum="205E907D0ED96B37" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP56</accession>
    <name>A0A5N6TP56_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_158975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742174">
        <property type="protein sequence ID" value="KAE8148132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP56"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="434" mass="47352" checksum="219914B7DA489BDF" modified="2020-04-22" version="1">MDMVSRQSSRLLRSPPHALTTRVPQTSRLPISALTTTHTLNNIQRRNVSSSRRNLAPESIFNFGSGSQSGVPATYFANRSTLPMNTVVRFVPQQTAWIVERMGKFHRILEPGLAFLVPFLDRIAYVKSLKESAIEIPSQNAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLTLDHVLKERTTLNTNITQAINEAAQEWGVVCLRYEIRDIHAPDGVVEAMHRQVTAERSKRAEILDSEGQRQSAINIAEGQKQSAILASEAMRQEQINRAAGEAEAILLRAQATAQGIDAVANAIAADKENAHGAISLSVAEKYVDAFSKLAKEGNSVVVPGNVGDLGGMIANAMAVYGKVSESQARSIAAKSLGVQESSVAESPRQRPEQASETGHDAVEQSPKEDMTESVLDEFSDNFRQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP78</accession>
    <name>A0A5N6TP78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_168662</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="13"/>
    <dbReference type="EMBL" id="ML742174">
        <property type="protein sequence ID" value="KAE8148115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP78"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024871048" description="glucan 1,3-beta-glucosidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="78"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8148115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="385" mass="42465" checksum="B0C6ABC881D98563" modified="2020-04-22" version="1">MVKLYHTFIFNTYLALIAAQYLDWSTYKSNGVNLGGWLCQENTIDTSWWAQNSKGAEDEWGFCVNQGSQCGPILEKRYATYITPTDIDKLASAGINTLRIPTTYAAWVKVPGSQLYSGNQVSFLRNIATYAITKHGMYVIIDVHSLPGGVNGMPFGEAVGHFGWFNNQTAFDYSLLVIDSIIAYIQNSSHPESYTIAPINEPVDNDDFSAFGFPASLSDDGAAWVLKYFTAVLDKVKAVNQNIPVMLQGGFREVEYWSPQFSIDANLVFDVHHYYFLGLQAAGQNITSYICRDAEIGAGDGKFPVFVGEWSIEAEINNTLDGRQGALNTGIYAFAEASQGSAYWTAKFSGNATVDGEGTQADYWDYMTWIDNDMINPEEGAGVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPH5</accession>
    <name>A0A5N6TPH5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_23317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742178">
        <property type="protein sequence ID" value="KAE8148031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPH5"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="223" mass="25691" checksum="7A4858D3F768FDD3" modified="2020-04-22" version="1">MSVQRASLSPPSVEVIPLNLEHDGQPQFEPSFFEPYRGFLPEPDAEETYPPFTGVEGPFCKPLDWAQDINDYFQTYLATVQQETKLPIRLYQPGRFGHNLWERSPNSNWHISAFDYITDEPRFKCMMLNDVIGCDTVTREELLCICRIMVKVLRYYKNHLVAPVMVLSFMGPRHGRILVAHHNGDSLVIGKSELFDFQHKNIDAFKTFAQWWCSSGVGNTMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPL8</accession>
    <name>A0A5N6TPL8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_23062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPL8"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
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    <dbReference type="InterPro" id="IPR013120">
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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        <property type="entry name" value="CARRIER"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="516"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112151" checksum="51DEBE8D9F41D928" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ29</accession>
    <name>A0A5N6TQ29_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAS/CSE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_158191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EXPORTIN-2"/>
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    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="962" mass="108550" checksum="DD7087C25760FDDB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQE5</accession>
    <name>A0A5N6TQE5_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_158173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742158">
        <property type="protein sequence ID" value="KAE8148494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="494" mass="54660" checksum="1BE87DA4DC1D8D4C" modified="2020-04-22" version="1">MHSGMEPKPDLESPPPGSVTMSPQEVDSGSFLEEEREKHLVWKIDLHILPMVVLLYLFSFLDRVNIGNARLYGLEEDLGLVGNQYQVAVSILFVTYCLFEVPSNLVLKKLRPSRYIASISFIWGVIATLTGITQSYGGLLACRLLLGVVEAGLFPGLITYLTLFYSKRELALRTGYLFSSAAAAGAFGGLLAYGIGFMDGISGLRGWRWILILEGIPTVILGIATWFILADEPDTAYYLNDDEKALVVRRRMRYVGQTASAQKFHWADVQEGALDWRIYAFSIAQFGIDTMLYGYSTFLPTIIKGMGSWSVPEVQALTIPCYALGAIAYLLVAWISDRTQRRGLFICIFSAISVVGYGILISDSSSGVHYFGALLIALGLYVAVGLPLAWLPTTLPRYGKRTFATGLQLTFGNISGVMSPFLYKNDEAPRFVTGNAVTLALVGFAGVVYGLMWYYYRQKNLRRVQGFEDEKVAGMTDDEIAELGDKSPRFIYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQP0</accession>
    <name>A0A5N6TQP0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742154">
        <property type="protein sequence ID" value="KAE8148594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQP0"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024820695" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23214" checksum="A3E61EA4F00FFB63" modified="2020-04-22" version="1">MINIKALAALTVLGLVNAQDSISFGPAFSLGPTQSWIREANTTLVLPETPSPQKDRLALWPGMGTSGGDLIQALAVSFSDPSANCGASSGQWCVWASTLQGTQLGGKQVPASAGDKVVMHYKYNDSTSKYDQTVILNGETVSTLSTSSGQAQGWGTAVEAQDDEINCSVAKHQYLDTTIILDSADSTFAGTLGLTNADSTGLESSDSKTFTVDTININAHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQR7</accession>
    <name>A0A5N6TQR7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore Sim4 complex subunit FTA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_15406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742152">
        <property type="protein sequence ID" value="KAE8148637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQR7"/>
    <dbReference type="OrthoDB" id="3432781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="28115" checksum="08BD118B815D2DA5" modified="2020-04-22" version="1">METYLNLCVSEDILNVDEHESLPVDSDYPLLKRFAGYQDDISQPEFINSGTQGCVFRFKYNGHDLCLKVFRNWEYPRSLHDAMPFNVSRKTQRLLTPFARECRAFARLCDLQQNGTWAVRCHGWMYLSDNQIAPLKKISMKLRRDPEWVNARWAIVKDFLPGPPTSADLPAIFSNFDIAKKARILPGDAFAKNYRGPFIVDLGSSATFPFPRHFASQYSFDRFYKCCPEGVFEEDWLGSLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRH7</accession>
    <name>A0A5N6TRH7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_141312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRH7"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="174"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="589"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="954" mass="107487" checksum="B3EF0B5E7242C887" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRL8</accession>
    <name>A0A5N6TRL8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742138">
        <property type="protein sequence ID" value="KAE8149003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRL8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="69134" checksum="BF057D83E335FD27" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSC0</accession>
    <name>A0A5N6TSC0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_4897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSC0"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="482" mass="51399" checksum="76663AB395586F0E" modified="2020-04-22" version="1">MSATKAQSQKIFEKLKLKPANKVCFDCSSKNPTWSSVPFGIYLCLDCSAHHRNLGVHISFVRSTNLDQWQWEQLRLMKVGGNESATKYFQSHGGSAALASKDPKVKYTCNAAVKYKEELKKRAAADAEQYPEEVEITDVPAGVSSNGSSTPAADADDDFFSSWDKPSIKRPSNPPSRTGTPPVVSRTASPFLNAGANGNGSRSKSPLSASDKETSPAPAAIRASATARKTTTASTAKKGSLLGAKKAPKLGAKKIGGAELIDFNEAERKAKEEAERIEKLGYDPEAEKAEADAKAKSATTGAAPIASPTPISPSRNTRTSQERNSNDVERLGMGIGRLGFGQTVGAKPAAPKKLGFGSVGPTRSAADDEELKQAKTRFGSQKGISSDEFFGREKFDPSAQAEAKERLRQFDGATSISSNSYFGRPEDDLPAGDDTYGDLETAAKDFVRRFGITAGDDLENLSQIVGEGAVKLQGAIRNYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSK5</accession>
    <name>A0A5N6TSK5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_167895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSK5"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009330">
        <property type="entry name" value="LipoPS_heptP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06176">
        <property type="entry name" value="WaaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30489" checksum="5FBF7E02FCC71D42" modified="2020-04-22" version="1">MSLSLQSGRPVILSMDVSGTDDSDYRVMIQGRVRYLTIARGTYDRSTLSTPLDSLPYLPESDAWNRARISRDSSTGELKAEVCDEVLPGVQDTWHPESFDCLELQRVKRLTAATFEATCPGHTLSKPTSTVVAKIAHFWWEIPRLAQETRIYKSLENTGLAPRFLGHVHEHGRVIGILLEKLDGREANIDDLPACRSVLKKLHAVGIRHGDVNRYNFIVRGDAVKLIDFEGSEMCHGDAASLEAEMASLEGELNECTGRGGGFLFKDTQSWSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSN0</accession>
    <name>A0A5N6TSN0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_3905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nuclear DNA replication"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="501"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="569"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="678" mass="75924" checksum="CDB696366615B85B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV1</accession>
    <name>A0A5N6TSV1_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8149377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
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    <dbReference type="InterPro" id="IPR013809">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="606" mass="67127" checksum="48A7DE908FD8D32E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSZ3</accession>
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        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_156432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSZ3"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="275" mass="31774" checksum="D76BD345A8870F48" modified="2020-04-22" version="1">MIPPLLIYRRSSPSYHPTGIQDNPSTPKTTKHNTNQNMAIEVVSLTEADIPGAVEVIQQAFADDPYFQWVFDSSQFNKQRNYDSLAVRCLWGINNALFQVARETTPDNGTVDSEQRSSSSRILGVSCWLPPHPTAEPESWYGWFQGWMLTWRQVLNNVWHWGRGGLITRRYWIWKARQEEAQSAIWDDPRGYYFCNIVAVSPDAQGRGIGRQLFEAVTEQADREGVKCYLESSRNVPNVQIYEKMGFRMKKEMVCRDGEDVCMLYCMVREPNTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTW8</accession>
    <name>A0A5N6TTW8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_130138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTW8"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41714" checksum="D63FDA23445ED314" modified="2020-04-22" version="1">MSSHDAIPETPRVISPSPAPSESRSRSRDGYAGPTTRSAARRQRLVDVSEESNNESGSRRSRTRSDSPASPLKSPRQRKRKSNPMRPAKTPESQTNGKSNGFLSPLPKPNGISHTFSRSPSPMGLIPLHTRYRNFIHRHEIPRKALHVSIGFVTLQLYRCGIQASQITPWLFGALVPIAATDVIRHRSETVNKIYIRCMGALMRETEVKGYNGVIWYLLGAYTVLRFFPKDVGVMGVLLLSWCDTAASTFGRLYGRHTFQLRKGKSFAGTLSAWLVGVVTAAAFWGVFVPSVGPFPNDPENAFMFTGRLNLIPDSAKNLLGWTADTSRAVVTGPLALGVMSVVSGLVAAGSEFVDLFGWDDNLTIPLLSGIGLWGFLKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU60</accession>
    <name>A0A5N6TU60_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_172532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU60"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="27673" checksum="F1CDC811146A502D" modified="2020-04-22" version="1">MSISKACCSIPPVLAKGYQPKGEYITLNGLKTYVVGPEFATDAILLVYDIFGFFPQTLQGADILATSSPIRQYRVFMPDFFEGSPADISWYPPTTETHQEKLNTFFQTKAGPLNTLSKIPGVISDANKSASNGKGFAKWAIVGHCWGGKIASLSAGQGNTTFQAAVQCHPAMVDPAEAKNVNVPMAMLASKDEPSEDVEAYRSGLQVPHHFETFSTQIHGWMAARSDLEDELVRKEYERGYAVVLSFLEQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUL1</accession>
    <name>A0A5N6TUL1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="7">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="7">EF-G2mt</shortName>
            <shortName evidence="7">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MEF2</name>
        <name evidence="10" type="ORF">BDV25DRAFT_172474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8149987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUL1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04092">
        <property type="entry name" value="mtEFG2_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001636">
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            <begin position="795"/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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    </evidence>
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</entry>
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            <fullName evidence="3">BTB domain-containing protein</fullName>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30755" checksum="4E7165E6D8F9D575" modified="2020-04-22" version="1">MFHCQIDLANNARVVRSDSFTFLIGPDHVPFIVHAGVVKELSAPLTAMIENGSMKESVERVAVLEDIEIETFGQFCEYAYKGSYTTAEYVERNAETASLTPGWGNPRGLSPTPTAPAETLHPNTALERDFARKFHALSFQVGDASVQSTASNLNPDFLGHAKLYFFTTRYLIQPLRMQCLQSLHRDLCDFKLNKDNVFRIIDLLAYTYTHTSPHEPGSCYLREMVSLYTAYTARSLAKYGGLRELMEENTEIAIDLVERFVFESNIGVQQGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW30</accession>
    <name>A0A5N6TW30_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_110228</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW30"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="394"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8150507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="527" mass="58190" checksum="5A96E9C9DA99B38C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWC5</accession>
    <name>A0A5N6TWC5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_154106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWC5"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="111" mass="12638" checksum="0D233C72E2719251" modified="2020-04-22" version="1">MSAQAYYELYRGSSLGLSLTDTLDDLINEGRIEPQLAMKILSTFDRVITEVLADKVRARLTFKGHLDTYRFCDEVWTFLIKDVTFKLDNQTTVQADKVKIVSCNSKRPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWK4</accession>
    <name>A0A5N6TWK4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_112128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWK4"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="200" mass="21699" checksum="DADA29C92D82578F" modified="2020-04-22" version="1">MSTRAHWMRRANEALGELSTSPCPFSAFGTAVVNHTGTNGLGDLICLGVNENRQTGNPALHGEIAAIQNCTDILTDPQGRFRLTPLKALNAFADLTLYTNAESCPMCASAIRWAGFKEYVYGTSIDTLVRNGWGQIRISSHEVFQASSDLSSSTRLIGGVLASETNPFFLWQFNSSYPCPGGCSRSEATGRCRAIKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXR1</accession>
    <name>A0A5N6TXR1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXR1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14391" checksum="BC0604096DB352C1" modified="2020-04-22" version="1">MAWGWHESEDAHRKVNEGKHEGHLSHELIAGAASFAGMKAWEDHQRKEGKTVNHAFAKEALAAIVGSQVDRLAETKGMDQIDKMRAHEHAKKNAHHMYEEHYERGHSAPEYDPSRYGRHEAFDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXR5</accession>
    <name>A0A5N6TXR5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXR5"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="73" mass="8144" checksum="90BAC5E232934474" modified="2020-04-22" version="1">MAYWKSAGLTYNRYLAVAARAVRRSLQEGPRLAAERRGQMDLRFAKWENGKQGEVKALGQANQDAMAANSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY42</accession>
    <name>A0A5N6TY42_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_97547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY42"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="78" mass="9024" checksum="7D10B7BDA069F71A" modified="2020-04-22" version="1">MKFITLLQFSRLLFSFSVTEMHVSIPGLSPSFLFYFFFLSSYFSLNSRVLQAAYVHLESYRNVVNACYASTSHPQIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY48</accession>
    <name>A0A5N6TY48_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_139159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY48"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="716" mass="79477" checksum="F64A21ED4529E1C4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY80</accession>
    <name>A0A5N6TY80_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_96312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY80"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="293"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="551"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8151275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="636" mass="71093" checksum="6895F1B0BE19071A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYJ5</accession>
    <name>A0A5N6TYJ5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline racemase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYJ5"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047580">
        <property type="term" value="F:4-hydroxyproline epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000005">
        <property type="entry name" value="Proline racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF5">
        <property type="entry name" value="BIFUNCTIONAL TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE_2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029792-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="345" mass="37245" checksum="608BFB0807F5AF96" modified="2020-04-22" version="1">MVNFTRHIQVVGCHCAGEVCDVITGGVMNPPGCKTMYEKLVHFRDKADHIRQFLMQEPRGRSAMCLNLILPPTHPSADAGFLIMESDEYPPMSGGNTIATSTVLLETGMVEMVEPVTRLTLDTPAGLVTVDADCEGGKVKAVAFNNVPAFVFKLDLQIDVSGLGSVTLDIAWGGMIYAVVDIAQFGLAINNANGPRLIAIAEAIKAALNKCDYIPVHPENPAIRGVSILEFTEPLDRETMEAVNTVVVSPGRFDRCPCGTGSCARMAILHARGLLGVGERFTHKSIIGSTFECYIRGTTTVGGYEAIEPTVKGSAWINSFKQYVLDPTDPWPTGFRVGDQWLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ09</accession>
    <name>A0A5N6TZ09_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ09"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="149"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="292" mass="33433" checksum="A8617242545C1822" modified="2020-04-22" version="1">MHQTPRPLNYGRTDWRISSQRAADLYSSGTRLWTKKDLEDIEQQLRQSYTMETFSVRRIDGSIIQIYNPMFQVQNPIWKPHVKYQEYWQLVKAQPNGPIETYLCTYIVDWSNQTARNFRELIAQPMQVFDEKQLLWQNSKTCRQLAALVQDVLGTNTVKKILCFGLGDFCRSAPEWLKNQHNSWDENLEVKNVMGCMIQHSMALTIAQLCRGNETLPLLAQDPDYTEVAEDILTKKEFKIVGTHGAGGFAEIDEDSIIISPFAAAPVKQIIADLARPLLIISTGFGVFNSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ33</accession>
    <name>A0A5N6TZ33_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_90662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ33"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF6">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40705" checksum="5B2607AFA5975644" modified="2020-04-22" version="1">MSSAERKRIRDRRAQQALREKKARRIAQLEEQVAHCEQHHQDHGIQRLLQVIQGLRRENHMFRVRQRRLKSFVDAWDVDPLGEDNLHGCPQECRPPQPHQNPPSHIPHDVTPAGTPPDSFVRPASSPPCPHGNARPANRPPWRELPLHLDDFSDVTTISCPWFMYLEEIIPCPDTPESPLDILYGTKTNPLANLIHKSLQRRPVRDPERLAIGWTIYRLSRWILSPSVTTYASLPLFLRPTADQRQIAHPLVLDFVAWPQIRSNFIRQWHLYQDQRDDLFGLLSCCIKIRWPWGEPILERNADNELCIKDTFYQTFMDEKGWGVTPEFIRNYPQLFAGVDVDSILYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U025</accession>
    <name>A0A5N6U025_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_80512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U025"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="162"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="448" mass="50168" checksum="CA34850E95EAEB32" modified="2020-04-22" version="1">MEESHLRQSISHHPSPFQTTHIPRDRATSILSYNEATTTALEPQAPQHRTASSDEEGQPPPRYTAENDPFQLASKLKTDEEIRQIQPRANTARKRDSCAAGALQNPKTALKGAVASKQLQGFYHSQNENIQRMLKPVEEHVRHAREINSNNQLKYKIAVYGSFAANIVLSILQLYGAIASSSLSLFTTMADAVFDPLSNLTLLLCNKAVHRVDPRKFPAGKARIETAGNICFCFLMTAVSFILIAFSIRELAQGSDSETADFHLPSVVAVVVAFATKLALFIYCFALRNHVSQIRILWEDHRNDLLINGFGILTSVGGSKLRWWIDPMGAIILSVLISVLWLHTAYHEFQLLVGVTADTKMQQLITYISMTHSPFITAIDTVRAYTSGPRLLVEVDIVMDPNESLRATHDVAEELQMKLESLPDVERAYVHVDYETTHKPEHFLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U064</accession>
    <name>A0A5N6U064_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U064"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25357" checksum="D867C584A849A344" modified="2020-04-22" version="1">MTGVERRRRQNRLNQRVYSEYVKNKQYTVVLCQPVGPNIPRKAQNPPDKCTADTSTSQHAERQRQILEQLTSAAYASYLQGSPNIDHLFTLTKLNVYRAFATSIGLLGLIQRLLHHHPWLDFFPHPGVRDNLIRVQGGYDEDELCLDIFGYWDPGVADNMLLLWGFLYNSTNWEMTEAFMVKWDGTNLWRARRGESPITRYLDLFLGVWWVGYCRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0W9</accession>
    <name>A0A5N6U0W9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_151270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
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        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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        </location>
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            <end position="40"/>
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            <position position="134"/>
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            <position position="227"/>
        </location>
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        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="288" mass="31517" checksum="A8770376146459F2" modified="2020-04-22" version="1">MPTETHHYGQDHALQTVTVTTLDTQVDKGYWLIFIHGGAWRDPTQTSINYLNPTASILTNSPTYSSAARRITAFASIEYRLSPHPSHPQDPQSTDPKECRTAKHPDHINDVQAALAFLQKKYGFGERYVLIGHSCGATLAFQSVMGAFGAGFPGPVAVLGTAGVYDLKLLRDTHREISAYREIVEGAFGTDEAGWDAVSPAVVEGVNGVADGWKSGRLAVLAYSANDSLVDPEQREVMKASLGPWVKSRPGRRVEMFSLQGDHDDCWEKSEELVKAIAFTLQELQTDA</sequence>
</entry>
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    <accession>A0A5N6U1G0</accession>
    <name>A0A5N6U1G0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_151148</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="402"/>
            <end position="459"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
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        </location>
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        </location>
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            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="51719" checksum="DA53D37078663D75" modified="2020-04-22" version="1">MSGFQPRPKRAGEDFTRTHQHLEEDEDGQSSKRPRFDLRNPSALAPDALEDDDILDADEIGRRGQQVRRKAVNLDGYDSDSDNEGFDGRAEAQARKKNQKEDAEDDDMFAELQEDFGAEDVDADDVLRKNKKNVRFLRDDEIEGQVASSKGGGTVHVDLSQGYKGKGAVKTDEEDDSESDIADEDRARVDEEIDEEVGAGGKKKHAPLLDAFNMKTEQEEGKFDDQGNYIRKAVDPDAIYDSWLEGVSKKDIRRAKEAAEKRDAERKEKDRINDSLLTGDVLKTIITHLEKGETILEALARLGKGAQKKPKWQNKRNKNRSKQNGEGTKDTEMTEDDPKEVARKQAIDTLTGAADVLMTRGQAEIYDTERELLTRQYRRETGEDWVDQPTEDADIASGEQEPTMWEFRWSDARDGGIIHGPYDSATMESWKSAGYFGEGVEFRRTTETGGWNTQATFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1G1</accession>
    <name>A0A5N6U1G1_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Nuclear pore complex component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1G1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="298" mass="31847" checksum="F7439D9536C64530" modified="2020-04-22" version="1">MASPSTPSTPKATPPAPFADASRTPGKWRHPQLNEIVRRQNAGTFGDRNLRRLLWNGAALLGTGLFGNTFKAYSLRLQNFSQFSTYPDLSLIALQLIFLFNILVALYPLFRPKDNLSDIPLTPTQRALLGLDPSATTSLTPGSTYVTPPKYRLSGSGSRAGSPASRAASPLSASASASGHRLSSGPTFSPSTSPLFHKAVSNGGRDTGRRPSFGSSSPLGRSSPFKESTFRESSFRESGFGSSFRESNFGSTFRESSFGSSMGPATPSPVGGKRVNLGLSNKWLYERSRRLSASNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1K2</accession>
    <name>A0A5N6U1K2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
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            <strain evidence="4 5">IBT 18842</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Wiebenga A."/>
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                <person name="Chovatia M."/>
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            <strain evidence="4 5">IBT 18842</strain>
        </source>
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        </location>
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    </feature>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
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                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2R7"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="490" mass="54210" checksum="1B07BC7D32A7C95B" modified="2020-04-22" version="1">MTSRDGYQWTPAAGLCSGLPSTGVISPPTNLPPGSSHWDVVVVGAGYAGLTASRDACLAGLRVLLIEARDRIGGRSWSSNLDGYPFEMGGTWIHWGQPHVWREISRYQMRQEMSQSFDHSRGVNYFQLRTDHGSSTMTHADEDVLMATALEKVVNVDGALGRTIMPYPHDAFHDPEARQYDEISVQDRLDELSLSPEEGSAVEAFILLCSGGTLPTTSLFEFLHWWALCGYSYQGCMEYLASYKFRGGQSSFAIQFFREAQSTGRLSYVFQSPVQSIQDQGSQVTVTSRDGQTYSATRLVVTIPLNVLSSITFSPALDSQRITAMEIGHVNQTVKVHAEISNRDMRSWSGISYPFNKLLYAFGDGATPAGNTHIVCFGGAQNHIHPEANVEHTQQAVEAMSPGNMDITRLVFHNWSTDEFAQGAWFFPPPKLLSSSLDALRRRHGNVLFANSDWAVGWRSFIDGAIEEGTRAAKTVTDELRVLRDLPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2X8</accession>
    <name>A0A5N6U2X8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_44712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2X8"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="596" mass="66346" checksum="386DCBB76F90C41F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U369</accession>
    <name>A0A5N6U369_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_150598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG11"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
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        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="96"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="813"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="897"/>
            <end position="938"/>
        </location>
    </feature>
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        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="1243"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1301"/>
            <end position="1311"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1311" mass="148114" checksum="E088CB7CF08B32E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U388</accession>
    <name>A0A5N6U388_ASPAV</name>
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        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_150656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <end position="176"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152711.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3C8</accession>
    <name>A0A5N6U3C8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3C8"/>
    <dbReference type="OrthoDB" id="4411232at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="200"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="310" mass="34363" checksum="DAB52DB6AD8F345C" modified="2020-04-22" version="1">MSALTWPPQYGKTIEPNIGAGAHGGSFFRKRDVDHPIRKIEVWAAPSGDSIQGIRVTWRSSTSATIGTQGVEHPAAIDLAEDEKINEMSIWADTTYVHRVHIKTSSDQTLDAGRENGDKFDMNTASGFLAGFQAYADASKIYELGPYFLKPYVPGRTNNPLLGDSRGGNDYTALNLDRRVSKIQVWWGSGAEPKNSIDRELRKMKLTYEQADEKWFSGNAGPAPTMDKTYEFDLQARELVTKMTFWQREDGGGFRCLSGFEFETSKGNTFTIGTKTNKVYPVPDLGTGVLLGFEGKLGYCMDRATPVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3F5</accession>
    <name>A0A5N6U3F5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-dependent dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_42763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3F5"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="4">
        <location>
            <begin position="97"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="473" mass="51326" checksum="7112B8DA9F6BF39B" modified="2020-04-22" version="1">MKKTIPAPEIAEHNTPSDMWIVVHGRVYDVTAFAPEHPGGADIINAHAGRDASHIYNSVHPPSLLSELNAHYLGDLDPATIPAEWTQPAQATSQTSTALEDILNLDDFERAAEHALTPKAWAYVNGAANDNVTRDANRRYFADIWFRPAIMRNVKTVSTRTSLFGCTLDIPVYITPVGAARLVHEEGELVWARAAAASGIVHCISTASSYPLGEILDATPKRAFYQLYINVTRSKTEALVRQAEGSGKVSALVVTADLPVMSKREADERTTFTGNEKAFPQASPGKRSTGVARSNSAFIDSTLNWDDLHWLRGITALPLVLKGVQRAEDARKAAALGFDGIIISNHGGRAADTAAPSILVLREIHKYAPEVFRHTKVLIDGGFRRGSDVVKAVCLGVAAVGIGRPFTYALQYGQDGVEHAVDVLRDEIQTAMQLIGMTDLMRDADPRYLNLAMIDSLLPPDYDSMGGGLKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3G6</accession>
    <name>A0A5N6U3G6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_137210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3G6"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="268" mass="29157" checksum="F324DEE97C5A5B87" modified="2020-04-22" version="1">MSMTIQDAAQTRDGFPRPFPSTPTNVLDQLRMTDRVVVITGGADGIGLSVAEAIAEAGGNVVLWYNSNKAAIEKSQQLAKTHNVKSAAYQVDETIKKVVDAFGKIDAFVANAGMAISKPILEQTLPEYRKQMSVNVDGIVYSAKYAGEVFKRQGFGNLIIISSMSGHVVNVPVDQPVYNATKAYVTHFGKSLAREWREFARVNIVSPGFFDTKMGASPLCIQEAYRMSPMGRQGHVKEIKGLYLYLASDSSSYMTGSDILIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3M9</accession>
    <name>A0A5N6U3M9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_44981</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3M9"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="118"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="417" mass="45677" checksum="13652DBCD10A8116" modified="2020-04-22" version="1">MGSTAAGSPFTIDNLPYGVISTAGNNSPRCATAYDGDAIELSLLEEDGFFSTVSGLPEGVFNQPNLNLFASSQQAAQAAVRSRLIEFLSGEISQAKKERYFIPLAQVTNHWPMATANFSDFYCSYEHTKNCSDAFGLTIKQNWYCIPSVYNGRTSSLRVSGEPVRRPWGVITGENEQATWSPSKRLDFELEMGVFLSKPLAAGDVLDIKNANEHIFGFVILNDWSARDIQWFEIAPLGPFHSKGFGTSISPWIVTTAALAPAQCPAVIPQDPKPLPHLTWKGEANQATWNIELTAKILRKGKTYDVTTTNLNYLYWTPSQQLTHLTSAGEGLATGDIFGTGTISSDRVNESGEKSGLACLFERVLPKHKLSALEQDGIEYLEDGDEVVMEGWCVNPQSGKWFGFGQCRAEILPALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U417</accession>
    <name>A0A5N6U417_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">3-propionate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_127375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153314.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="363"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="606" mass="67819" checksum="27D266FBE318187A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U493</accession>
    <name>A0A5N6U493_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_27635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U493"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="109"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="393"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="469" mass="48955" checksum="FE7711D6B6A656E2" modified="2020-04-22" version="1">MSASPSALQSTKRPLEDPSSPSGPNDQPEAKRPALDKVVKGEESDAYAEVKTESSTVPSANADGQGDTVVPDAPNAKVVLPETQPIQSTASHADTGAQADQHQPQDESSWIHIRAVISSQEAATVIGKGGENVSQIRRLSGAKCTVSDYSRGAVERILTVSGPQDAVAKAFGLIIRTLNNEPLDAPSTAQSKTYPLRLLIPHILIGSIIGKGGGRIREIQDASGARLNASDACLPLSTERSLVILGVADAVHIATYYVAVTLVEQLTERFGGPAASAYATRSGGPAGAVPGGMQVVPYVPQPAGGQYGHPDTFKRHHPHPNRAAAGAYGVPYLHGQPAPAPVAQPAMHYGATPHTPYAGAGPHQPTPYGAPQAVPARGGPTPAAPVAGAMPGQPLTQQIYIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQENSNERLVTITGTQECNQMALYMLYSRLESEKHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4E4</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Lubbers R.J."/>
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                <person name="Haridas S."/>
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                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="KAE8153513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="263" mass="28839" checksum="508D9D12C054DE37" modified="2020-04-22" version="1">MNQVKDINTLSSYLSSPDLPNLSTTPVDSIIICASAILHQATHLFATLQSRPNLTKSLVLCGGIGHSTQFMYEAVAQHPRFNCIAESIHGLPEARVLERILDTFFDRAAITSRGCEILIEDRSTNCGLNANLSKDVLEGAGFTGLKTCVVIQDPTMMRRTKASFVKAFEGVRDPPEFVGCPVFVPRVSLDDGLGFEDVEGFKDEGELWSMDRFLDLLLGEVPRLRDDEGGYGPRGKGFIPHVDVPGDVEEAWARLKIGSRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Q2</accession>
    <name>A0A5N6U4Q2_ASPAV</name>
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        <submittedName>
            <fullName evidence="12">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_127092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="689"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="833" mass="90369" checksum="99DC039D7BF0A8B2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4T0</accession>
    <name>A0A5N6U4T0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_168747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4T0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="516" mass="58696" checksum="BAEE7E768EEB2745" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U541</accession>
    <name>A0A5N6U541_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U541"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025004417" evidence="3">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="228" mass="24871" checksum="B833424AEF938684" modified="2020-04-22" version="1">MYLLMLILLTVLAITTTSDIAPCVKIHIISARQSNSWPGEGRMGELSAAIIQKVPNADSEALDYPAYGDLWRYRGSVLAGDTAMVHAISAYIFRCPDSKIVLLGYSQGAHIIGDTLCGSIVELGFAQSAPINDTLGSKIIAAVSMGDPSFFAGLSYNNGTNKVNSGWFARRNNTVCAKYDAARVSYCDVGDKFCASGYRFWVHRKYMWRYKDVALQFVLARINGSKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U561</accession>
    <name>A0A5N6U561_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_168445</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U561"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025035531" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8153670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="438" mass="48596" checksum="33576BC9DBDC90BC" modified="2020-04-22" version="1">MGLLSILSLFLPFGFSILSGSSSSVRVDGNNCTVRPLGHGHDDVPNILYAVEKCGQTAGGRISLPAPYTYRVNQRMTTHLEGSLLNIYGALFFSDDINYWVNNSYRVDFQQQSTAWRITGHDYVVDGGPHRGGIDGNGQLWYTWAKGGSNVFGRPMPLHVLNSTRAVLRNIAIRQPQFWAVLVESSSHIELDNFYVNATNSDPDATDDTQWIQNTDGIDTYRSDNVRITNWVYEGGDDAVAFKPNSTNIYVENVTVYGGPGIAFGSLGQYPDRYDIVENITVKNVSFQPSFQRAMNSGIYFKSWIGVNYGVPPNGGGGGHGYVRNVTVEDITFKDVQLPIYIDTCLSYLFNENVTQFCDTSTYRFDDLRFRNIHGNGLATPTDYTGRNITFAVSLICSEAAPCTRLAFEDVDIKLPEWYTGNSVLCEHADVKGLTCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U586</accession>
    <name>A0A5N6U586_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U586"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="107" mass="12726" checksum="74338A623B4A10F0" modified="2020-04-22" version="1">MFKASSPLFSGLLWKIPWRISQPQKARQRKRLRSVDRVVDTVSAALTRNGHSARSVTRWFKEMPREEEMLPKDKYTLFDKKEKTYRKGIHKLPKWTRVSQRVNPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5M1</accession>
    <name>A0A5N6U5M1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5M1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF485">
        <property type="entry name" value="MULTIPLE EGF LIKE DOMAINS 8, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024897981" description="Kelch repeat protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="56675" checksum="F91E936810293310" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5N0</accession>
    <name>A0A5N6U5N0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_149275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5N0"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="142"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="355" mass="39033" checksum="084EE1881EE83DA8" modified="2020-04-22" version="1">MSQQKLKVAIAGLGRMGARHAHHFYALTPRAEVVAASSPVQKELDWADQNLGGARTYLDYDQMLDKEQAQGLQAVVIASATSVHAEQAIKAIKRGLHVLCEKPLSINVDESQSVVDAYQESIKQFPSQKVLCGFSRRFDASYRDAYEKMNSGMIGTPSVFRSQTCDKLDPSGFFVEYAQFSGGIFVDCSIHDIDLALWFFGQDSVVKSVTAVGITAVSPELRKYNDRDNALGLVEFYGGRIAQLYCSRMMAAGQEDSTEIIGTGGKLAVNTQPQLNLVNIFEPSGIRREIPPHYYGRFRDAFITEANEFTASCLDNTELPVKLEGAVAAVRIGAALQESLITGKKIEFNEQGQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5P8</accession>
    <name>A0A5N6U5P8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="7" type="ORF">BDV25DRAFT_168477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5P8"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="304" mass="34267" checksum="08BC53D76F6E6520" modified="2020-04-22" version="1">MALVQYSDSESEDSQGESVRPPAKKQRPERTPLPEPSLPPLPKAFHDLYASSTRISVKDDPSLHGGRKRAIPHVEGNWPTHIYLEWYPLKQELTVLSDVIEQIEQKRRRCCTRLNSLLRSDLGAQLPLHISLSRPVVLRTEQRYSFMDTLRSAIRGSKISTFDAQFEGLDCVSNYERTRWFFVLRVKKPEGDALNRLLRLSNQSLAPFGQPPLYESSAHVVDATTSPIGSMQWQQGATPHTPKDYSHCFHISVAWTLAEPSPEEREQISNLDLREINGLAVGFDCVKAKIGNNITSIPLSNGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5R5</accession>
    <name>A0A5N6U5R5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5R5"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000007">
        <property type="entry name" value="Regulatory protein SUAPRGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="303" mass="33885" checksum="7B876D491E9C8D4D" modified="2020-04-22" version="1">MMSLRTLTRSVPRTISRSLAISSRSALFRPVPAVPRNGIQSALQQAMKPSYAAFSTSRAFKQSAAEGDFELVAKLEDELKHEKASGLEDLDSSVQNIQYVLQNNSWEIKDVPGEQEVSLTKKFGNEEIRLTFTVADLQNLSEQEELDALGDELDFDQPANKGNAGSVSQAPEDSVSPADREMEDAEPSFPARVNVTIEKPSNGALLIQTVAQDGLFQIEEVSYFSKPDLAHAQTAEKDWDRQSLYAGPPFENLDEDLQTYLERYLEERGINAELATMIPDYIQVKEQKEYVRWLESVKNFVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U688</accession>
    <name>A0A5N6U688_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_17839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U688"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="249" mass="28392" checksum="DA56147AB2ECD3EF" modified="2020-04-22" version="1">MSIVESVINMECTQIQLRLAVPQDLPFIAEVAAQAMLNDELFAFLCPRRKDYYSDYRRGFLRRLRTKLKAPGWVIVVAVVNSPAYPSTDSMHIVGYSVWERIGESTEAGTGKQGEVEQGWLNNIQENIWDLGDQLFSWLYPDRSVDRSHLAAYSALTEECFPYSAYPKLWFLSTLAVHPDYQRQGIGRKLVEWGLGQAAREQMPVGLEASAKGTYLYHSLGFRTVNEMPLIENITLRAMIWDLPKDAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6U1</accession>
    <name>A0A5N6U6U1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_136019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6U1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF35">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024931153" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8154326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="458" mass="50220" checksum="049531DB21ADEF1E" modified="2020-04-22" version="1">MRGLSWAQLCGAAVLLLQGQSVLSAISVEVNSKDSLANAGKEIANPMMDFYKKNQTEGIPGKLTDTWYIAGAMFMTLIQYWATSGVDSYNKVVKHDLMFQAGENYDYFSSNYSQWLGNDDQMFWGLATITASETGFPEVSGKPSWTSLARAVFNMQVGRWDMTKCGGGLRWQIWPYQAGYTMKNSISNGGLFELSARLARFTKNDTYAEWAERIWDWTASSPLMELDRWWVGDSTSNDNNCTDPGRNQWTYNYGTYLSGAAFMYNYTNGDEKWLKRVDGLLGSLLATFFPSDYGSNVLSEAACDGIGTCDRNQLGFKGYTAMWLAHTAILVPSTVEKITPKLQGSALAIGKQCSGGSDNLCGQCWGKTTWDGTQGLEVQMAALGGITSNLMLLETKAPQTVDTNPDAAEHHINNTESSSSDPSSLKPIETKDKAGAWILTVMIAAGVIGAVGWLIKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6V0</accession>
    <name>A0A5N6U6V0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_172388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6V0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="543" mass="61273" checksum="BF9DB3FB3DF105FA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U704</accession>
    <name>A0A5N6U704_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BDV25DRAFT_148620</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01028">
        <property type="entry name" value="DEHYDROQUINASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 21 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 21" id="KW-0521">NADP</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 21 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 21 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="24">
        <location>
            <begin position="77"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="27">
        <location>
            <begin position="191"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="411"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="25">
        <location>
            <begin position="1294"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="26">
        <location>
            <begin position="1546"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="EPSP synthase" evidence="21">
        <location>
            <begin position="397"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinase" evidence="21">
        <location>
            <begin position="1056"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="21">
        <location>
            <begin position="1289"/>
            <end position="1581"/>
        </location>
    </feature>
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    <sequence length="1581" mass="171494" checksum="FCDCAB7338F9E72F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U7X0_ASPAV</name>
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        <submittedName>
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        <name evidence="12" type="ORF">BDV25DRAFT_147343</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">IBT 18842</strain>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="MCP_transmembrane"/>
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        <property type="entry name" value="TXTP-like"/>
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    <dbReference type="PANTHER" id="PTHR45788">
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    <sequence length="327" mass="35385" checksum="44466845E3FE944A" modified="2020-04-22" version="1">MSAKTAQGKNGNGKKPPSAAVNLIAGGGAGMMEALVCHPLDTVKVRMQLSRRARAPGVKPRGFVATGVEIVKKETALGLYKGLGAVLGGIIPKMAIRFTSYEWYKQMLADKETGHVTSKATFLAGLCAGVTEAVAVVNPMEVVKIRLQAQHHSLADPLDTPKYRSAPHALFTVIREEGFSTLYRGVSLTALRQGTNQAANFTAYTELKAALQRWQPEYSNSQLPSYQTTFIGLISGAVGPFSNAPIDTIKTRLQKTRAEPGQSAVSRIMVIAKDMFKQEGASAFYKGITPRVMRVAPGQAVTFTVYEYLKGRLEQSNWSLVGGKYEE</sequence>
</entry>
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        <name evidence="10" type="ORF">BDV25DRAFT_147335</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7Y6"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="124" mass="13120" checksum="1EBFB89EBE7E19EF" modified="2020-04-22" version="1">MVCSKCAKKLKTTELATPGVKRKSEMYYGSPSTSLGGGSGEGSKKPTLGNTGVGKSKLLSSKAKNPYAAYASSCEGCKTKTEQGKKFCQRCAYQRNACPMCGKSLTGKSSKDQPVVQGKKYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Y9</accession>
    <name>A0A5N6U7Y9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_135673</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7Y9"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="12">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="11">
        <location>
            <begin position="320"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8154753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="58477" checksum="73C9A2A14F8AD38B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U803</accession>
    <name>A0A5N6U803_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative lectin family integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_147378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U803"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000245">
        <property type="entry name" value="Similar to lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845548" evidence="8">
        <location>
            <begin position="17"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="45436" checksum="E653B799C2E5CB9F" modified="2020-04-22" version="1">MKISASITLFAALSAAQVVIEGSSFGYGETLSPNRDTIPGWSIGGEGHSPQVLSNKLILTPPYPGNTRGFAWSQTPVSQSEWTAEFQFRATGVERGGGNLQLWYAKDGQSKIGTSSIYTVGQFDGFALVVDMHGGRGGSVRGFLNDGTTDYKSHRSVDSLAFGHCDYSYRNLGRASIVRMKHTNSILEVTVDDKLCFSTNKVALPAGNTFGVTAATPENPDSFEIFKLILQSVQSGSTPVQQQVNQQQQQQQQPVAPQGQASQQQEQPQSAQGVTNEHIVDLGGRIELINKAISNQGKLSETRHQDLQQKFATKEQVASLDARLQRMEQILQTIQRDLEGKDYRDRLSQIQESLRSSHLTVTEILQGSLLEAVTASAPRMGFFICLIIAFQVFLATAYIIYKRRRANMPKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U937</accession>
    <name>A0A5N6U937_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U937"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="36480" checksum="C948B1CE965C288A" modified="2020-04-22" version="1">MNNDDSRELILQLLVQDYVEGLGQDWEHRTGNPEIADTLAAQNRIVENYLNPPSPVHEMAGYFYPFEPYSHEPNSHEPYNHEPYNPGPYNPGSHRSGPYSPEPYNPGSYSPEPYSPGWARHEANMMVYPPSQSHLLGRGGYYPGPTGGIYETRPSTMDYATMDRPVARTPDNGGGHAYQMQQPLKRPVGEGAGTRTAETAPERCFLERPAAKVQILLFLAAVVMMFHRSQLCISSAQRNSASSMQETRSVEEKAPAARIPSAPNRSQTPRSSRIWPSVQRAGQELISPVAPSPTQIKVARRIPGSKRSWNWPKPSTGGDVINAGQWSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCR9</accession>
    <name>A0A5N6TCR9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_167676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML743110">
        <property type="protein sequence ID" value="KAE8144092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCR9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="122" mass="14366" checksum="0EDFE79E3F39CF9B" modified="2020-04-22" version="1" fragment="single">MSRSPGWICIFALAERMHLQEAEVKNASLYNKDVGNESAEKKKKKKKKKNPFLLIGTRKSRGLVVVGRQIVLYFVLKPRYICNVHGFVCNRPNKNCNHELPRRTMVQFLKRRKTKRRKKNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCW2</accession>
    <name>A0A5N6TCW2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_167473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="ML742690">
        <property type="protein sequence ID" value="KAE8144183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCW2"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="376" mass="40539" checksum="22106B8CB3C94D0D" modified="2020-04-22" version="1">MAAPRLFRPAARLLSSRLSTPLRPTFRQSACAPSILRFRGYATQGGVKDVTVRDALNEALAEELESNQKTFILGEEVAQYNGAYKVTRGLLDRFGPKRVIDTPITEAGFCGLAVGAALAGLHPICEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVSPWSSEDAKGLLKAAIRDPNPVVVLENELLYGQAFPMSEAAQKDDFVLPIGKAKIERPGKDLTIVSLSRCVGLSLNAAAELKQKYGVEAEVINLRSVKPLDVETIVQSLKKTGRIMCVESGFPMFGVSSEILALAMEYGFDYLTAPAVRVTGAEVPTPYAAGLEEMSFPQVDTILGQATKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD51</accession>
    <name>A0A5N6TD51_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_99175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742570">
        <property type="protein sequence ID" value="KAE8144318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD51"/>
    <dbReference type="OrthoDB" id="4227165at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="250" mass="28254" checksum="1D3890DD8C5A9F49" modified="2020-04-22" version="1">MPEPPKRVVLEKSRTVRRRYQRSNKRLQFTASQIARIEREEERERRAQKLRNQEKRRIANKKKKAEKEAKAREERRRLGLPDPNVSTVPSSQPSLFNFLKKGPQASSNQESTCEDIETGTPGSITTEVDTSEDSGLENDEFSDADIVELENALNEGYDPTETDGIEGETRDDDEFSDCSIFYDESIIKEAEMGTKAPALGQVQLAVEMAPVSVPLAESFQDDTAILLEEFACEFDADEEFEQELARLDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDU4</accession>
    <name>A0A5N6TDU4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_167172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="ML742582">
        <property type="protein sequence ID" value="KAE8144291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDU4"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000003">
        <property type="entry name" value="Anthranilate synthase component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="56825" checksum="89EB230974DA0001" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEA4</accession>
    <name>A0A5N6TEA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_145435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742472">
        <property type="protein sequence ID" value="KAE8144626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEA4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="541" mass="60627" checksum="3EF2B08F0885F048" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEN9</accession>
    <name>A0A5N6TEN9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_90860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742484">
        <property type="protein sequence ID" value="KAE8144571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEN9"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="344" mass="38677" checksum="6305CBDC9E4ACD1C" modified="2020-04-22" version="1">MKYVRLGSSGLRVSPICVGCMSYGTPGKPLSWTIPAEKALPVLDHCYRSGLNFFDTANVYSNGDSEVILGRAIKEYGWSRESIVVATKVWSPVGRGAERPLGLSEEERDRSGYLNQYGLSRKHIFDSINASLKRLGLEYVDLLQIHRFDPNTTPKETMEALHDVVKSGKVRYIGASSMYAHQLLEYQYTARMNGWTEFITMQNLYNPIYREEEREMFPACAKFGMASIPWSPVAMGFLARSWKGDSETTRGESMNGGLMGHAFTDTDRKINEKVEEIAKSRGVSMATVALAWTLSKPFITSPIVGMSKKERVDEAVQAIDFELSEEEIKGIDDLYEPRKVIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEQ8</accession>
    <name>A0A5N6TEQ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742429">
        <property type="protein sequence ID" value="KAE8144822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEQ8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="53" mass="5771" checksum="070F241C3DCC2FE3" modified="2020-04-22" version="1">MTSFSVGFAPPAINLLTRMFFSAVLGFFSAAVVPPNSRHVLGWRTMLISRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFD0</accession>
    <name>A0A5N6TFD0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBA domain-containing protein Ucp14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742428">
        <property type="protein sequence ID" value="KAE8144829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFD0"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31362" checksum="0D58F789D77D21E0" modified="2020-04-22" version="1">MQTSGLTNTPLTKTLLIYLLTTSIALSILDIKHLAAIHISPHILLYAQYWRLLSWQLLGFTNSTEALFAAMLVYHLRVVERAWGGRKVATFLLTTLPYTTLLPPLLLILLIRPLSLTRMNYLPAGLTSTVFALLAQYHVEIPCTVRYTISTSTSSSGAGAGADAGAGSTSDTSSGPSSTSSPGSGSESKSLTLLFSDKSTTYLIAAQLALSQFPGNLVPALIGWFVGLAWRMEILPGSGGGWRVPAWVVGEKERVVGSGRYEDLRRRLEGEAAAVEASGVSSSSTSGSAGLSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFG7</accession>
    <name>A0A5N6TFG7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_165615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="ML742404">
        <property type="protein sequence ID" value="KAE8144990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFG7"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024842969" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="131" mass="14091" checksum="200CECC11A1FDC98" modified="2020-04-22" version="1">MRLAILSTLLISLVSAAELGIEKTKEVECTRKTVKGDTVLMHYIGSLQSDGSQFDSSYPRGEPLKFRVGAGMVIKGWDEGLLDMCIGEKRTLTIPPEYGYGSRGIGPIPGGATLVFKTELVGIEGVSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFP5</accession>
    <name>A0A5N6TFP5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_134000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742374">
        <property type="protein sequence ID" value="KAE8145194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFP5"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="346" mass="38386" checksum="6C7E29CEBEACFA93" modified="2020-04-22" version="1">MESSQSDWSISVTPSRSQSNANDTNRNNNGNFHSTVRSHQESHMSLRINNGNNTGQRAFRDSVGRQERHIPSGFYSFHHSDIDHSESVYAPNRPNLRIDSQVVTVQNGVANGTQPSIGAEQAVHVIQPRENAGNSNHRLRSCTSIMGDKRTKRRLITLIISAVFLTFVVALYFAITASESSLGQELHILLIFMILILAIVLCHSLIRFFIIVLRSSGSAVAMNRIPSRVGPTGYAQPESPIHVILARDEEVLSERNGASGEKVAAPPPAYGLWRSSVRINPDLLYWQRVRDNAPALPQRASQVPGTKFSMPRPPSYTSDNGVDYAVEAQPQHFTHCGNSERRECLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFX1</accession>
    <name>A0A5N6TFX1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cut9 interacting protein Scn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_170794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742383">
        <property type="protein sequence ID" value="KAE8145130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFX1"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="388" mass="43754" checksum="C5A6E3B7CCEAFA61" modified="2020-04-22" version="1">MAQPDTQDGSTFPWELGVFDAHCHPTDTMPSIPEIPKMRATTLTVMSTRGQDQDLVHDIATSLRDGQGENIGRVLPCFGWHPWFSYQILDDGEATETNNTSDPTRRKVHYETVLTPPPDEKFIATLPEPKPLSQLISETRQRLLAHPNALVGEVGLDRAFRLPQAWTPEDNENRDPQMTPGSREGRSLSPHKVQLEHQKAVLKAQLRLAGELRRPVSVHSVQAHGAVFDLFKALWSGHERKKPSRRDRARRYSAANAHAESSGEEEQEEPLKAKEPPLPFPPRICMHSYSGPVEPLKQFLNPSNPSDVYFSFSSVINFNGPSPQKVIEVIKALPDDRILIESDLHTAGQQMDDLLEEVARQICELRGWDLHQGVRQLAENWKKFVFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGK3</accession>
    <name>A0A5N6TGK3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body associated protein SnaD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_164701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Makela M.R."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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                <person name="Nybo J.L."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
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                <person name="Nybo J.L."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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    <sequence length="75" mass="8858" checksum="897E9F854D46EBB7" modified="2020-04-22" version="1">MPTARLRKAFRYPDDSGGEFDHEELDEEEQEFIIQRLQVQNDRRNAEYSVTDFPFIMLISWPVADERLISTSHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH17</accession>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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        <text evidence="2">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
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        <text evidence="1">Belongs to the sulfatase family.</text>
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        <location>
            <position position="39"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF00884"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Apc15p protein-domain-containing protein</fullName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742332">
        <property type="protein sequence ID" value="KAE8145570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH51"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
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        <property type="entry name" value="Apc15p"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="316"/>
        </location>
    </feature>
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            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
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            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="373" mass="41107" checksum="7F7982FBA6CDFD7C" modified="2020-04-22" version="1">MMLSLPLLTPRDSHELWFGSSQLYRSSAQHSLSHNEPQGDLHRNGSNTSNGRVFLAPTTSGSTLSSLLLEERALRARKNNIASFGYSWIKPAGCAKTMLGMKEEEAEREEALAAAAAEMAATAAAAEAGGDGTDGFGTQHDEVQDDTGMERDLDDDIPDADAEGLVEEGEEGLEDEGAADEEGYMERDLDDDIPEAYPDEYDDDDRVVDSGEENEEYFDNQPDLDDEIPSASEIDDELEGISEGDMGRDLDDDVPEAAEDRSEQEDEWQHTDTDAEFDDEDDVSFSHDPFTQSLRASVTSSRGLPPAPVRPRETEAQRRFLQRWSGGGDVFDTSSMLVDEDDLRASVTSQGSRRSFLSRFPRRRTGGSRDNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH60</accession>
    <name>A0A5N6TH60_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_144439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742323">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH60"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="49" mass="5803" checksum="DFEF320582A5A5D2" modified="2020-04-22" version="1">MSFITPPFWVLVHLELSLSHHFHVACLLCLLLILTQQVDKSRWLRKNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6THV4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_163495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742299">
        <property type="protein sequence ID" value="KAE8145954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THV4"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000102">
        <property type="entry name" value="bZIP transcription factor hapX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="52866" checksum="E26BAF11A0E16ECE" modified="2020-04-22" version="1">MATPAPSIAPAPAAAPLAPAIAAKPTISPSPGPATPGSITSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVNELEDQIKKIEDDHEIHVVQLKEQISNLSHEVEQCRNEMSWWRDRCHALEKEVSVERSAKEALVKEFRSSLSDKNTPADRAPLTRVSARNAARALEERVPNNINTHDDDEEEVPLGCPNCSMGHCQCIEDAFTMPGIESSFNKRPSASTLSRSEPEIKPDPEEMEIDFTTRFAAPRPQEDTATAVSSPAVDPCGFCQDGTPCICAEMAAQEEQRRQSFENNRLAPIQNLSQFTPPPSDGDVRSEVTLPPISEATNPCANGPGTCAQCVADPTSTLFCKTLAASRSASVASSGCCGGKGADGGCCQSRPSNPPRGRSATTAKQPSRRSATPSLTLSCADAFTTLSRHPKFSHASDEISTWLPKLHTLPNPKDVASPDRTSSRAAMEVEAASVMGVLRYFDRRFADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI01</accession>
    <name>A0A5N6TI01_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742295">
        <property type="protein sequence ID" value="KAE8145994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI01"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="387" mass="43037" checksum="7769386DF1EB84DC" modified="2020-04-22" version="1">MWLWRGAQSAVFYYATCTPCAEKGDRRKRMKEAKVARSQRAKEKSDDIVTDQPRPFPQPTAFSTNPGWADEIALGPGPPARRGGNRSAHRRTDSWNTDANSCQNGNATHKKDKGSIMQPIEDRWNRLRNQREDEPLWGEDVEIKGSSVGLAGSGKASGHEPSKYYTAKAPPVNDLHPPIVSGPKSRAETRWMLQPPPSARVMAGKEHFNTSSQTNKHTDIRTTAADKRTSTRSPERTQLPPISTQPVEKKITPTSAPVSDRRALKTPEPRDNKPSSPGYGRGDSNSAVGSSLRSRSDSSTLPSPTDSEFESPRVSIQSPETPVSRPMSKGTDDDNRPYRPHVSKALTSLQRDDKKVELLHLEISDLHDEVGLGQLEHMRPWRWSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI56</accession>
    <name>A0A5N6TI56_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_59273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI56"/>
    <dbReference type="OrthoDB" id="4508069at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="201" mass="23046" checksum="18106AE31C416E30" modified="2020-04-22" version="1">MPLFRRLKSRLSSSRPAKHSRPVDSKTTESADGEFAASHRSHKSHIPNGAQPEKVIQAPLEPVFNPSSQEPPHYWQNIDRPADTTRPHDQSFFGFHPLPGRSRSRLVMRPRSNMNSTLPGYNAVSGAVIVDWNGFPYFLSPEEEHERKLKLERAVQERMMGLSKQTDFAWSRPSHGTTLPRYSSKRDTLSPRPSFNKRQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIA5</accession>
    <name>A0A5N6TIA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_56494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742288">
        <property type="protein sequence ID" value="KAE8146083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIA5"/>
    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021641">
        <property type="entry name" value="DUF3245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11595">
        <property type="entry name" value="DUF3245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="235" mass="25464" checksum="612B0FDE2A5A0374" modified="2020-04-22" version="1">MAQRTDMSAAKTETDIILNKANVALARSQRLVASWLPPKTSEEQAIVNSESQREDEIFVAVPETLGVGAPLPSKTADGSWNRTELDNNDQLRKHLLGRNYKAVVAEGNPPANRRDSKVRSSLSTTLTTNQFQTAASRTVEDESDDEDGRTALVGKKKQPGKRKPESGCLALEPLGHGQDADKAKDGNGECGDGVGEGLVRQGASFSQSTLGPKRKKKAPSFLDEILADRSKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TII3</accession>
    <name>A0A5N6TII3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_133187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742284">
        <property type="protein sequence ID" value="KAE8146142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TII3"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="340" mass="37832" checksum="0C8FDBD6AB15BBCC" modified="2020-04-22" version="1">MIGDFLSRCHDTTWFFLHIIILNIPPTRLFLFPALAASVWFATLASLLLTWIARGMPRYPGQSNPHVAFISDIASFELKPLFLVGASITAVGFVSTVAAVHVVRYEPGFALVKGPRETLVDDRSDHEDSDDSHSEDEEDHETTRTLKLISLLAIFAAGVASTALILLAVMDTFRYKNVHHIFLRTCFAGLAVQSACTAVVYSNEVLGFVSYVYHMGIWQHDWGKRSLRVRVFASLSTALILVEVFLGVAFISMTMPDKNPSYRTGGILEWIIAFLGTIYLWLFCGFLDRTNFDGFVPSILYNPPKLPEDGPSLSTPQRHTPVSDPERAPLVESSAGRKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIL1</accession>
    <name>A0A5N6TIL1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_144193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIL1"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
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</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Chovatia M."/>
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                <person name="He G."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAE8146456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="50" mass="5667" checksum="228906556EABDC41" modified="2020-04-22" version="1">MCSQYFYKYDCGCTHPEGDVVYCAKRGTDCTGVRQQVRRREGYNCPAHGG</sequence>
</entry>
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    <accession>A0A5N6TJE5</accession>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="54" mass="5940" checksum="AB0E3B0A37D18DA7" modified="2020-04-22" version="1">MRWSGLQLDRNPMSLLNHHFATGLTTSSRLMAIVSFLLGSLLVSGVIMIAPRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJH5</accession>
    <name>A0A5N6TJH5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742257">
        <property type="protein sequence ID" value="KAE8146524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJH5"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="216" mass="23197" checksum="E7CB6797B32B7D8B" modified="2020-04-22" version="1">MEKPSTVSGQLVEEYDERREMSVKDEETDVVAAPVLQDGFYHHDLYGQSGKNQDAHPPAQVDPVPTREAAPTTDLDTTHPSVISEMTGIPTSKTQLSQTKPAQKQTSAPVTSGNAPTTFATSTIKHTAPTDTTHQAEATTSLSKASSQSAHSDTSAYAAHCVSRETGQEGLAPRACLSIWPICRAESKLSVYIDRDTPYAMSLASRPMSPSGRFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK40</accession>
    <name>A0A5N6TK40_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_47227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742250">
        <property type="protein sequence ID" value="KAE8146630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK40"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="91" mass="10431" checksum="1931C3E1A232193B" modified="2020-04-22" version="1">MRLGESKNPQALKAVKPHGRLTEPTRNNRKPFPRPPAQETKKNKLKVNSTFVSCNFCFMLFMTVWSYNSVDRIPPHLPLYLLFLISGVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK96</accession>
    <name>A0A5N6TK96_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_169602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK96"/>
    <dbReference type="OrthoDB" id="5229017at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="391" mass="44645" checksum="EB76A6F53727AF58" modified="2020-04-22" version="1">MHNTSFAIAIYQWILLDYDDMAKLNSFYEEYESFWNVVPKMSTMSTSTYSSTGFTSHHDHQSLFPPKLTPTRRLDIQTYTQRPTQETYRLAVRDGHQYTPSYNTYYGARNSQTAILEFENHDETDDLLQPDFETCPRGPARTTRKKLFGANGWLGVTAEVEEVSHEKQITKKIHGLGKKIKQQVGELAEDIAKAAPQAFVHELRREKAPAASTVHISLDPPTQAKLYSELEVMICVSANAFLLEQYKDGRLSSASIAKVSSFWETKNRPQVTEFQFDQATQRRLIFSNKRKLGFHGESSTNPVRLNSNLRNWEAIAKEMNVRTFCAPDSAIRKHLHDVHRLLEMLGAPLVTLMVLQNLEMRTVSMMKDRLEKNYRVDGRDSTSSIGSPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKF4</accession>
    <name>A0A5N6TKF4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Spb1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_161670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742240">
        <property type="protein sequence ID" value="KAE8146826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKF4"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
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</entry>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="449" mass="48245" checksum="EB23792C75274960" modified="2020-04-22" version="1">MCALQPLSGKISVVFSLRWSYLAFFVVFLLGSLLCGLANSSKMYIIGRAVAGAGGAGVVSGGLSVIAIMTPDAQRPLFTGLMMSLYSLGTVVAPIIGGAFTTNVTWRWCFLINLPAGAVTVITLLCFFHPPKASVLEGPGQTIWQRIAQVDLVGCGLFIPSIVMILLALQWGGGQYAWNSATVIGLFVGFAGAITVFIIWEVRQGDEAMIPFTLLRGCSVVLSIIFGFLILGSAVIPVYYLPEWFQVVKNADPMRSGVMVLPSVCTQISGAIASGALAKYVRYYNPWCLVGSAFLCIAAGLYTTFTTSTPSSHWIGFQIFQGLGCGFAAQMPLLIVQNVLKDKPAHIPTGISTVLFAQYFGSSVAQSVGGAIFQNRLGEELRSRAGLDASQVSMLLDAGTSKVQETVNRAFPDRRDTVAMAYNNAITDVFVSPLNNRTHIRVTNRVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL91</accession>
    <name>A0A5N6TL91_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_161029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="ML742224">
        <property type="protein sequence ID" value="KAE8147122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL91"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="414" mass="45008" checksum="BC88833FF4EA7A9C" modified="2020-04-22" version="1">MIELGLSRISHLLQQTPLTWKAIHIAGTNGKGSISAYLSHLLTSGGVRCGRFTSPHLIDRWDCITIGERVVQESLFRQIEARVKLRDQTLGIGASEFELLTATAFEIFNHEQVDIGVVEVGMGGRLDATNILNNVLVSVIAKIGLDHQSLLGDSLEEITREKAGILKRSVPCVIDGTNSPPVLKTLEDRIKELDLVVTRTNPDLPDGHSSSLGRLFRQLDLQPHQQANMCCAISALKVALAKVRPELEADTLVPQLRHVEWPGRLQNIVLEPLVGRTEPILLDGAHNNQSAEVLGQYVESKLRTQGKPVNWVVAASRGKDLATLFHPIIKPGDNVATTAFGPVDGMPWVKANDSQELASSIQCIPGIGKVASFDGDVSAAINWACIEANGGPMVIAGSLYLVSDVLRRLREVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLL7</accession>
    <name>A0A5N6TLL7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AAA family ATPase/60S ribosome export protein Rix7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_160737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLL7"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000149">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein Rix7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="203"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="507"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="734" mass="80649" checksum="A86ABF6FCD7810BD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMF2</accession>
    <name>A0A5N6TMF2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_32267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMF2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="81" mass="9393" checksum="69B6A322DC7013DE" modified="2020-04-22" version="1">MWPISSTNKMRDNHGCHECHEIRKCGMRRGDPDGSNFFLFFSRLCPRPYYLASVFQILSFLHFSSLPCRNLSVSVTHIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TML8</accession>
    <name>A0A5N6TML8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_142842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TML8"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="613"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="974" mass="108655" checksum="B20AB71CF9AFF19E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMT1</accession>
    <name>A0A5N6TMT1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_159779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMT1"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="179" mass="18059" checksum="4768481CA7F4D40F" modified="2020-04-22" version="1">MANKQGKMQNLINYRMRVTLNDGRQMTGQMLAFDKHMNLVLADTEEFRRVKRKSKPAAGPANAPLVESEEKRTLGLTIVRGTHVVSCSVDGPPPADPSARLGSSVPSAAAAAATLAAGPGISKPAGRGLPVGLGGPAAGVGGPPPPGGFPGFPPGGFPGAPPPGFAGRGGPPGGPREFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN71</accession>
    <name>A0A5N6TN71_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_28417</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN71"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="19">
        <location>
            <begin position="559"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="18">
        <location>
            <begin position="1122"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="797"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="962"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="989"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8147755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1268" mass="136688" checksum="C2FFA58078D2E7FF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNF5</accession>
    <name>A0A5N6TNF5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNF5"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="45566" checksum="06BB45A699A647F5" modified="2020-04-22" version="1">MTKLSENTTAAMRAAIDETTSGASPSIPGLVYCAVNRDGDVFFHHTSGRRGVDSEEPMTLDTVFWMASCTKLITSIACMQMVEQGKLALDDVEQLETLAPELKAVQVLERNNDGGFRLVLKDRGITLRMLLSHTSGFGYAFEDLKLRDWSRPVGLDDFSGQRADVLHCPLVNQPGTKFQYGVGLDWAGVLVERVSQLSLEEYFQTHILKPLGISTITFFPSPEMIARLAYMHQRAQDGTLSVTDHINRSALLPCLPGMEKLRSCMGGAGCFGQPIEYCRIIATLLNDGTDPKSGTQLLKPATVKEIFTDQIPDKPRYCNEFTPSGKPLLANPCPLVPCADDLTEGWGLSFSLSHQQSSTGRAAGSGSWEGLANLFWFADRSNGVGAIIASQILPYGDLPVLTCMEAVEEMIYREIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNH8</accession>
    <name>A0A5N6TNH8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_25759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNH8"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="35669" checksum="290FCBA80F784ADD" modified="2020-04-22" version="1">MANLPFFRKAPQRPVYGRSASKVRWHRILRSFLYLIAWIFLVLVVVGNVADKPVLRQTYFLKVDLSNIIPLSIPNAVLINSIARSIGLHDFYQVGLWNFCEGYNDSGITKCSKPETLYWFNPVKIIMSELLSGATIALPGDIMDALKIARIASHWMFVLFIIATVFTFIMIFLSPLATSSRPPQTISPDPNINAANPAHRRRTFIFLRALPFLILAFLTALFTVVAAVVATVMFIIFKTVFTNDDYNLNIEAEIGTRMMAFMWIASACNLLSFILQLGSCCAACCGGRKARKTLKNGGLSTGPAHLREKEGSHSPATTATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNK0</accession>
    <name>A0A5N6TNK0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FG-GAP repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_26282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNK0"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025005887" description="FG-GAP repeat protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33791" checksum="B237A9994DD7E2C7" modified="2020-04-22" version="1">MANVNVFLSIWRMLVFLAAIHPVLGAPYQTRILETGTTFVAPDPYGPWQMIPSSSSSEDLAYIKTTNTGTGRVEVHIASGSSQFQTRTLEVGTTFVTEDNGTWQLIDADGDGRPDLVYIKTRSTGTGRVEVHIASAASNYQTRILETGTTFYPEDDGVWQMADFDRDGKLDLIYIKTRNTGTGRVEVHVASGASNYQTRIQEVGTIFYPEDNGVWQMVDYDRDGRLDLAYIKTRSTGTGRVEVHVASGSSTYQTRVQEVGTTFYPEDNGFWELSDFNHDGVLDLVYIKTKNTGTGRVEVHVASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNN8</accession>
    <name>A0A5N6TNN8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_168732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742181">
        <property type="protein sequence ID" value="KAE8147983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Sato A."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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            <dbReference type="Proteomes" id="UP000325780"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="26"/>
            <end position="56"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="782" mass="87753" checksum="CDB44C2FE0E1FD0A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQE6</accession>
    <name>A0A5N6TQE6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_158501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQE6"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="555" mass="62293" checksum="6A998954664CEFAC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQU6</accession>
    <name>A0A5N6TQU6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_157890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="ML742151">
        <property type="protein sequence ID" value="KAE8148667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQU6"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="494" mass="53555" checksum="1C6F29C8BF008F79" modified="2020-04-22" version="1">MVSKLAQNLKQPALDFLSYVNASPTPFHAVQSSKELLAKAGFQEIKEKDSWSSTCHPGGKYYLTRNSSTIVAFAIGKKWKPGNPISMIGAHTDSPVLRIKPVSNKRGEGFVQVGVETYGGGIWHTWFDRDLGVAGRAMVRSGDGSIVQKLIKIDRPILRIPTLAIHLDRQETFAFNKETQLFPIAGLVEAELNRTGESKSSGEDTTDEKAGFSPLKSVTERHHPYLVDLIAAEADVKPADILDFEMILFDTQKSCLGGLLEEFIFSPRLDNLNSSFCATVGLIDSVADASALDDESSIRLIALFDHEEIGSRTAQGADSNVLPAIIRRLSVLPSSTAGNEDLATAYEETLSTSFLLSADMAHSVHPNYSAKYEADHRPEINKGPVIKINANARYATNSPGIVLLQEVALKAGEDGGEGVPLQLFVVRNDSSCGSTIGPMLSAALGARTLDLGNPQLSMHSIRETGGTYDVGHSIRLFSSFFKHYSNTAKTIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR14</accession>
    <name>A0A5N6TR14_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_157697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR14"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF7">
        <property type="entry name" value="CELLULOSE SYNTHASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="204"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="614" mass="68771" checksum="D9CFCCB300C1A787" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRQ9</accession>
    <name>A0A5N6TRQ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_130708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742137">
        <property type="protein sequence ID" value="KAE8149043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRQ9"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF8">
        <property type="entry name" value="O-METHYLTRANSFERASE AF390-400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="164"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="342" mass="37838" checksum="3FD8DE7957F5F4C0" modified="2020-04-22" version="1">MFSVLQALIDVGLWDAWTAVGGEKHVEDLAAIAKKGVDPELLRHQLRLMAANHIVQETGEDRYAPTAFSLALGDKGTHVAPALRIRTDHIAQCAMHWPAFLAKTDYRKPVDDSDSCYVDSFPERKTFFERCSANPVHQESFSSFMDLWAKQKRPWPEFYDTTALLEGADLSDGSPFVVDVGGHHGIDLLRVLHKHQDLPAGSLVLEDLPDVVASVTLATDTIKTVGHDLFAPNAVQPVHWSRAYYMHAVLHDWSDETSVKILKQVAAVMKPGYSKVLINDIVIPTTGTSCYQATLDCLVLQASANERTEAVWNKVLSEAGLKLVKIWPDGRGYESVIEAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSB5</accession>
    <name>A0A5N6TSB5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">BDV25DRAFT_8698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742140">
        <property type="protein sequence ID" value="KAE8148961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSB5"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000143">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="357" mass="40453" checksum="CFB73B3C0B260C09" modified="2020-04-22" version="1">MPGKEFLDPCVDCRDADAALTLRRRRLCKDCYIKFVSYKVFKRMEKYRLNREGPRNTRCKLLFPLSYGLSSSVLLHMLHCQLETQRSKPHAPPGFDLEVLIIEPSTMYSVPQYDAGFDLVQKLFPLCTFTRISFHDIFDLVPDIQETMSHFAGDEFKDDTSKTNTERLSAFRSSITTATSKTDVDRALVTRLIVAFAKKTDSLAIIWGDSDSRLAAKTLANVAKGRGSSVTWQVADGMSPWGLEFNYPLRDLFTAELRDYAGFFPELTDLIIPDEQLSENTLTKNLSIDELMMRYVLTQGEKYPGVMLNVTRTANKLDVSQMPSNVSHCTFCGASMMNEQHNEFCYACARSRPALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSQ0</accession>
    <name>A0A5N6TSQ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carnitine acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_140829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSQ0"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="69"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="826" mass="91782" checksum="000F5D148ED34C16" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSQ6</accession>
    <name>A0A5N6TSQ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_130581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742132">
        <property type="protein sequence ID" value="KAE8149169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSQ6"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="256" mass="26979" checksum="2B18CAD56859A0DB" modified="2020-04-22" version="1">MSLKGKVAIVTGGARGIGAGIVQAVSQQGARKVSFNYVSSSSQPAADSLVQSIHASGKDAASIQADLTDPHGPTTLIQATLAAFRTTQIDILVNNAGQGDNRPLEDVTLESYNKLMDVNVRALVFTTQAILPYLPRGGRIINLSSISARGGFPTQSVYAASKAAIEGLTRVWATELGMKYGVTVNAVNPGPVDTDMYQAAGEVHLARMEEQNKKVPAGQRCGTTQDVADIVVFLAEERSRWVTGDVVCANGGMLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT26</accession>
    <name>A0A5N6TT26_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1561"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2458"/>
            <end position="2478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2478" mass="281220" checksum="06B2B33BB1C51969" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT27</accession>
    <name>A0A5N6TT27_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Peroxisomal membrane protein Pex17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_2097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149457.1"/>
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    </dbReference>
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        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="75972" checksum="50BCA20110292FA4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU84</accession>
    <name>A0A5N6TU84_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_120132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU84"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33760" checksum="8F5915F6EA7D1601" modified="2020-04-22" version="1">MAELEDFPPDYIPSTHITQVSVTDPIPDILSVIDRDGGVIVNGLLSTEELASIEREIENNTNANREGDHGYFTGIVPPETVLVGGLVGKSDTLARVCEHPVLEGVRKEILTDHGTRRIEGSDLPYHIDPLLSISVSFRIGYGAQRQRLHRDDGTHLIEHESKPYRLNQTAQLGCLIAGVETTRANGATMFVPGSHRWDDKREPKLDEVTFAEMKPGSALIFLASCWHGAGTNQVPGATRIVHGLFFVRGTMRTQENQFLAIPRSKVLNMSPNMLNLLGYRQPTAALGMVENTDPMLNLPAVLKAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU99</accession>
    <name>A0A5N6TU99_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pectate lyase</fullName>
            <ecNumber evidence="11">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_155516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="11"/>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU99"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025098674" description="Pectate lyase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="234" mass="24867" checksum="C6770440FE434FF5" modified="2020-04-22" version="1">MHANLALLSTLLPVALACLGYEGGVPTPTAEHSNSEVIEIAAGEVFDAGWAKYDRGSGACSGQTEGDWKDAVFYLHSGATLKNVIIGANQAEGVHCDGPCRLEFVWFEDVCEDAISIKNDKAGDETWIIGGGAYHADDKIVQHNGCGTVNIINFYAEDYGKVYRSCGNCSSQCKRNVYVEGTTARNGGEVVGINQVFGDTATLKNVCADADHPCVMYDGCEGDCEPEKVGYCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUH4</accession>
    <name>A0A5N6TUH4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_155163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUH4"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="111"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="568" mass="63315" checksum="9B95B91CB6153CDE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUU3</accession>
    <name>A0A5N6TUU3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_155103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUU3"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="818" mass="92438" checksum="09F64EDE8B81BD95" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWI2</accession>
    <name>A0A5N6TWI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_129418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWI2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="56055" checksum="4171F408044E7F27" modified="2020-04-22" version="1">MSDKEETLQHVEDKSTDYNEVNNSVAPDSVVQLNCTAVTESRLRLKIDLYIVPIASLMYLFCFIDRANIGNAKLAGLEKDLGMTGYDYNTLLSIFYISYIIFEIPSNMACKWLGPGWVLPALTLGFGICSVCTAFVHTLSSAAGVRFVLGMFEAGLLPGISYYLSRWYRRQELAFRISMYMVMAPLAGAFGGLLASAILKLPSFGNLETWRMIFAIEGIITIGIAIIAFLTLTDRPDTARWLTQAEKELATTRIRSESAHVGVAVVLDRLDMKKTIRGVLNPVTLVMAWIMLLVNVTVQGLAFFTPTIVRTIYPDRSVISQQLYTVPPYIIGAVSTLLIPYLSSRFNNRLIFFVLVPPIMMMGYTMFLASSDPRVRYGATFLIAFGSFPVGVLCNAHSAANVVSDTARASAIGAVVMLGNIGGLISTWSFLPFDAPNYYIGNGLNLATGTITLLTAAILWLWTTWDNKKRDKKGHQQQLESLAEMSSQQLEDMEWRHPKFRWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWI3</accession>
    <name>A0A5N6TWI3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC/TSA antioxidant enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWI3"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="248" mass="26741" checksum="530556B8174A4CEA" modified="2020-04-22" version="1">MADTVTDTPSVPATNISNPPQETDKVVAQDQLPSASLQQQVGEYTVFDRHGKTLPFKNLYSGPQAATRVLVIFVRHFFCGSCQEFLRSLSETIRPECLPANTSVAVIGCGDPGLIDTYAAETGCPFNLYADPSRKLYDDLGMVSSLALGPRPQYIRKGFAQIVGGSIWQALKQIPSGLAAKGGESSQNGGEFLFEPSGATGEKEITWCHRMQNTRDHTEISTLAHILNGAESQSGIQSTVGTEERETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWL8</accession>
    <name>A0A5N6TWL8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YAP-binding/ALF4/Glomulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_107343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWL8"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="674" mass="75079" checksum="60E4891CFD42527F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWP1</accession>
    <name>A0A5N6TWP1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWP1"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48466" checksum="938EC88D59FB89DD" modified="2020-04-22" version="1">MPPTTGKSIGDPNSDDYVAKVLTNEARENSLKYSTLGMGAYMPKRPTGAAPKPNTRFLRHIIKETDSHNAALKRKEEREARERMRQLRNQASSTSNTRKDASHRSSRTDEGRSHRDRRDDRDGRSGSYRRSHRSRSASAERDRSHRHRRRRESYDSDEDKHRSSRRSRRHQSYSRSRSRSPREHRHTKSHSHYRRRRSRSPSRSRSRSPDRHDRRRDRDNEHTHDRTREDGSSRQNSAAQRKLSPPSKDVQDQSVGYESDPLEDLVGPLPPQMDGSSSAGPIRSRGRGAYKANASNIDSHFAPDYDPTMDVQLEDDDETSTKPTRRPVAGLMTGDDDWGLALEALRDRARWKQKGEDRLREAGFSDTFVEKWKSNTNSTPGDSEGWLEDVKWMKQGEGREWDRGKYVNDDGHIDVKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWQ1</accession>
    <name>A0A5N6TWQ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PIN domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_172132</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWQ1"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="815"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8150499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="124914" checksum="4BDC9A89CC09E336" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWX2</accession>
    <name>A0A5N6TWX2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_153620</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="324"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="528"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="751"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="674"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAE8150886.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="807" mass="89163" checksum="7D811F1377E9D01E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX96</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Sato A."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="298" mass="34462" checksum="FD55C698D93DD476" modified="2020-04-22" version="1">MTHHYKFENLPQYFINYSEFAKQNPGSQATTPPNLGLIDQEYSKSDNQELDKTSKRPWERFANHINQLNIQSPENVSYKVLYLTRHGFGVHNHYHKTVGSDAWNNYWSHLDGNGTVSWVDAKLAETGIQQARELSDFWGNAVNTDKVPLPDTFYTSPLARCLETSKLVFTRLAEDAGKQFRPVVKELLRERLADHTCDKRSTRTWITDHYPLYIIEPGFSEDDVLWKPDRYESIEEHVARKQRVLEDIFSTDPGHFISLTVHSYAISAILRTCGAEEFRVREGSTIALLVRGERLDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TXJ7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXJ7"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="351" mass="37803" checksum="0A58AED7FBC5BDFA" modified="2020-04-22" version="1">MASIQQWTTPLKGVDSLQLGEAPKPAPGKGEVLVEIRAVSLNYRDVEVTNGEYTHHKSVEQESKIVPCSDMCGVVTQVGDDVTTWKVGDRVLSTFLPDHQTGQVTAKELSGGLGLPLDGVLATHRVFPDYALVKAPSYLSDEEAATLPIAAVTAWMSINGMRPMGQNGGEGEYIVLQGTGGVAVSGLQIGKASGAKVIITSSSDEKLAQAKQLGADYTINYRTQPNWEDEVMRLTDQHGADVILEVGGAQTLKKSFDCIAFGGLINCIGYVSGKMDAPDDRTNVNLLALRRTVTLKGIINGPKDRFEEMVAFYEKHQIHPVVNKVFSFPEAKEAFKFLAGGSHFGKVVIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXW9</accession>
    <name>A0A5N6TXW9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_139372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXW9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024880193" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="547"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="613" mass="66287" checksum="F0BE011BD96DE330" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ26</accession>
    <name>A0A5N6TZ26_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_171291</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ26"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="476"/>
            <end position="628"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="629" mass="70065" checksum="3FA9B7F463A3AC9A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZB4</accession>
    <name>A0A5N6TZB4_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_152409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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            <dbReference type="EMBL" id="KAE8151655.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZN4</accession>
    <name>A0A5N6TZN4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="194" mass="21497" checksum="476965B30266CC1F" modified="2020-04-22" version="1">MKSYAPTIALLVLSAFQFCLAEKQDIFEPANITAEQAAQLRDWRENGEHASQLPERPKNTAKNATQNTTHTEMEPATQRPETHKNTQVEKKPHDACNASKRRKRGEDLFAKFPQPAGRDCKNQLADASIEFNPTGPGTFSVRGIPPACMPLSGLFIDDPSQPKPIPLGPDTLEFTEISDEDLKELQAILDCRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U040</accession>
    <name>A0A5N6U040_ASPAV</name>
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        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">BDV25DRAFT_152199</name>
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    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U040"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="286"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="667"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8151719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="848" mass="92613" checksum="C347081CE929E241" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U095</accession>
    <name>A0A5N6U095_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_151868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8151964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="76" mass="9177" checksum="53D68958F5B2C146" modified="2020-04-22" version="1">MQGVSDQHHISLIMVVDAISREDNMRGTSNSTEHKTFFFLFFLFFSFFIFLFNFPVLIVYIFKVHRSIQMIMRIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0I0</accession>
    <name>A0A5N6U0I0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_138169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="174" mass="18989" checksum="9C7D0411F1A01FBC" modified="2020-04-22" version="1">MSPIQIPIDAITSRFGDRFNSLRSQSVGTRFANLRPISEFLDIKRVSKPANFGEVQSRVNYNLSYFSSNYAAVFVMLSIYSLLTNPLLLFVIILVAGGLYGIGKLEGRDLDVGVARFNTSQLYTGLLIVAVPLGFLASPFTTVLWLIGATGVCVFGHAAFLDKPIENAFSEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1K8</accession>
    <name>A0A5N6U1K8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_151106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1K8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="229" mass="25529" checksum="A1642DF7B193F951" modified="2020-04-22" version="1">MSNDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYDNVNRWLKELREHADSNIVIMLVGNKSDLRHLRAVPTEEAKQFASMFWPGSWMRDTPTNSVPGENNLSFIETSALDASNVELAFQNILTEIYRIVSSKALDSGDSGQAGLGDRRPVVDISTSQDPETKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U208</accession>
    <name>A0A5N6U208_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U208"/>
    <dbReference type="OrthoDB" id="4138121at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024895855" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="85" mass="9901" checksum="D9BB3393C9776FE8" modified="2020-04-22" version="1">MVFRWLGLRTFEVWLTGRLLASPTFHRLVARVHQKVQHMKHGVPPEELSGRGTHADDHGSSLKQFFGYFKEEIKDQMKGKPPNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U217</accession>
    <name>A0A5N6U217_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_150799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U217"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="449" mass="49899" checksum="8FAF80D58C7D149B" modified="2020-04-22" version="1">MGSNDQSWRKLNVGVVGGGIGGMSVAIALRRAGHEVTIYERNDFAGEVGASVSCAANGTRWLHEWGVDVEKGDPVVLRKLINRDWKTGEPVSVYDLTDYEERWGYVYNMFHRQYMHAMLKDCALQDEGAGIPAKLKVNHACTDIDLSTGTITFSNETKAQHDLIIGADGIGSVVRGIIGLHPEKRPSDQSCLHANVSTEEAVRLGLVDYSQNSALEYWGGQEGKWDKIVLSPCNGGRLLSYYCFFPRERGDFSSHTWGGADRPVEDLLEPYPELDRQVFSHLSIGKEIRPWRLWVHQPYEYIAKSMVCLLGDAGHPMMPHQSQGACMAIEDAAALGILFNERYFNGNIADTLAIYQKVRLPRATKVQSAAAKAAYNINERIGFSSNINNSVYKVEDEKKKLTIEEMNAYDMYKDIEEALSKQRGIPFTEPFTNGLPIGLELSTGVVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U223</accession>
    <name>A0A5N6U223_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_137706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U223"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="165" mass="18360" checksum="364E12AE70F5FDB1" modified="2020-04-22" version="1">MVQSISVATLPEEHAEYRDADGAWSCQCCPATFQRYDHFKRHLATHSSVRPHQCEFCGSPYKRGYGLALAMFTKLRKHVIIDIKWHKGCLASSLENNRAMAARESMLVMVVQDRRNAVAESFHASNVTPVGGYAPTNVSIKKTKLGNLELVNQGMNKANLISPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2L4</accession>
    <name>A0A5N6U2L4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_137463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2L4"/>
    <dbReference type="OrthoDB" id="4500730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="540"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="748" mass="86078" checksum="8573B18A67A54C66" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Q6</accession>
    <name>A0A5N6U2Q6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Origin recognition complex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Q6"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="451" mass="49898" checksum="DD3D3C9D07972265" modified="2020-04-22" version="1">MNNRPVEQALGTLLPTHAEDLPQDLVSLALSLVAQSRSFSVSLRPEEEIARPYACAEIACRRLTRSFKLPPLMGHPPCPPRVYKKLYAFLDRSLSASVTGVKRAGSTSGTPSRTGSAPSTPTKELKLTRTPSKTATTPHRLQNIPSKPTPLKSAITNRDPRQASQTPQKSVKFRPDGLSNSTIIPDAPAWAMTSIRAVCKTLSTPAPRTSTWSRPPISRTLPPHMFAGVSSILYFISQASANSDEEFDEDTADFVEPIMLVKDRENDEDFKELVNALIVAVYFLALARRRASSEVGGEAKKLDKKTFTEMRQTALVSLGLPSTERRHRDDVDQWIAVIMQQGLANGKEWFDNIPQAGELHGEDAYLSDDGDDDDAARSTKRQKTAVPGNQSLLVKDSRKGLLPGLGTMMQDRVDLLSDYRREDYREWKATIIARIDQMEKTAQRHFGVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3E8</accession>
    <name>A0A5N6U3E8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3E8"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="73"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="624" mass="71556" checksum="2B8BF918E20B8D33" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4B7</accession>
    <name>A0A5N6U4B7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-heptaprenyl-1,4-naphthoquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_127240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4B7"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="257"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="52680" checksum="A994C72E03A6D6E5" modified="2020-04-22" version="1">MSSYTENNSDALGILQDPSANKFLDSIVQGLPPQSRVLSVGCRASLPILSKFSSAHHEIHGIDRSQESIDPVKSQTSGQFELAEETEYAPDLTFNAILAIHSLSHLNRAQRCSLVYKISDWLHPGGSMILATPSDHVINRCHDHVDHCAQGHSLHLNGKTIRSSLPSRKEWITLCEKAGLTLEGEVPFSGNVGDPHHTLMHFRKTVQHSMVGPFPLPEAYRGPIPLSEAAWEPFATRLVRDEFDFVLEVLKNNQKVLDVGSGYGKLPMELAARTGKAYSIEPNPDRNSIQAMNAHNSGVEIAQGSAESIPYPDSHFDAVVAMWVMQYVEDLEKSLHEIVRVTDRSAKDSRIVIVQGAPENEVVELQNTACAPVSASNPLPNHQGYLLHKAVQVFTKCGFGDIAFHRVDAYCEFLEEDVSVRCEKAADVVAGLWCLDDERYEDMKQALMPRLRAHFEDRPHAIGDQVAVLVARPLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4X3</accession>
    <name>A0A5N6U4X3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_136624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4X3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025005060" evidence="8">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="485" mass="55484" checksum="1802DA3D37EB082D" modified="2020-04-22" version="1">MYHTIGLAIFITLSYFAFAAKHPLKLRSNYFKNGKGHPIPVVHQDTRFRRFTNGKEVSDEGSRRFGNSPYLVKNGKHHEVVISQPSHVKEFFSQDGSDHQKLHDCNMGSFFARSLGSCVGVQNGTKWRTTRSHLETHFSFSSAASMVEDTRRTIEQWAQNLPEDTEIGQKMSQGFQIDAVTACRQLPFRLIAMALYGPMFSEPMFARLWGLNSLHEQMTYVTFLSRWAATRLYRWFPTKANATLKNFEEQFKEFNLELIERGRKAGVAFPVESMYQAVEEGKVDMTSFLQSIDEILFTNIDVTSSMFAYCLINLGRQLGIQNSLRKEVREKPCTSDVFRYIQDENTLLHQVYLEILRNSPPAWFSLPELTAKDKTIGGYLIPAATPVIIDVRRLNQESPVWAPDGTAFRPDRWSSISKVDARYSLYGYGLGPRKCLGKNFALMMIKLLIITVLEQYHLGAGVETKIRRDTWTCTPDSLVSFEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Z9</accession>
    <name>A0A5N6U4Z9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_127065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Z9"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="261"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="553"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="915" mass="100427" checksum="35AA98F87BFB2865" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U516</accession>
    <name>A0A5N6U516_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_21926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U516"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="501" mass="56742" checksum="2C19F254E500F263" modified="2020-04-22" version="1">MVTFNLFRRVVSTQHHVRSAEEKALVRRLDICLLTFGCLSQVIKYLDQQNINNAYVSGMKEDLNLYGNELNLFTTYFNVAYCIMLIPSQVILTYVRPSYWLPGLEIIWGVLTGLIAMTKHANQVYVLRVFLGLCESSAWPGMITLFMYWYTPTEMAKRMGFYHSCQAAGQMMSGALQTAITNTMEGHHGLAGWRWLFVVNAIITVVWGIAGFFMIPDLPNNPNPRAFWFKRVHAELSMERLARNGRAEPKKMTWAGVRRTFSGWVVYFIAILYIATVLGTYGYVYFSLFLKALTRPDGSARWSVSQVNAIPIGGSAMNVVFVWVWALLSDFLETRWTLIVLQAVIGIVPCIIMSIWTTHPDSVGIPAAYASYFISYTCLGTAPLIFAWLSDLIPQDPEARTLVVGVAVAGYYAISAWSQVLVWPASQAPYYKYGWQSALALLVLVIIMTCILRFIDVRYLLPKRVAFRSVLDAEVVADPVKNDEEDPRDRNWKKPSTTVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5C7</accession>
    <name>A0A5N6U5C7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5C7"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="142" mass="16132" checksum="9347EFFAA4C569D3" modified="2020-04-22" version="1">MTNDNQVVIDRGSVAARYGLFKADAALYLSTGGFYGEDGKIHPPRNDRNIFQNLYGVGPSIAEKIEYTPTILVLERHAASGEREGINNSEARFHAFIRALEEANYTGNYLDRSLPEWHHLRELVTAYREFWDASDLVNEHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U658</accession>
    <name>A0A5N6U658_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BDV25DRAFT_136398</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U658"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAE8154030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="939" mass="100373" checksum="547453099D33CC41" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U667</accession>
    <name>A0A5N6U667_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_126812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U667"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="208" mass="22193" checksum="4EB968B1F69160F9" modified="2020-04-22" version="1">MATESVARKNAIVTGGSRGIGKGISLELAKRGANILLAYQSSRDQAEEVAAAEIRRSGVDAIAVEVAVNLKLPVFLIQASMPYFGKMPRIVHLSSAYARDGQSGCLAYVACKGAMESLTRSLARDLSHNYQATINCVCPGPVNTELWAATIEDPHEKEKWDFVVQNTPAAARVAEVDDSAQIVGFLAEGRSRWTTGSLVNANGGLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U680</accession>
    <name>A0A5N6U680_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U680"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="270" mass="30952" checksum="0EF2318F9004FBB7" modified="2020-04-22" version="1">MANETNMSHQAKSHLLSVRLWIGKRLFRRVGRSGVRISPHRIIKGPCEITELAALKYVAKHTSIPVPKVLNVYHHRDGLYIELDYVSGTDLQAAWLGGCLSQDQKRNIITEVTGYVSQLRTLEPPHKGIVGSADLEACLDHRVGPSTFGPFNEHAEFHSFLRRNVLIENCTQVFGEEVTDCHSRHYRSCFSHADLCPRNIIVDNGKVSAIIDWEFGGWYPEYWEYTKAHFGQIEMPEWYEGLESTMARYDVELRAERALWRQCDQPGMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6A3</accession>
    <name>A0A5N6U6A3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6A3"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF32">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="679" mass="76297" checksum="1C3563C7B8AAFE51" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6I9</accession>
    <name>A0A5N6U6I9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_127079</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6I9"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8153741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="749" mass="80476" checksum="38F0E5EDBF1F5E3F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7H6</accession>
    <name>A0A5N6U7H6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7H6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="27139" checksum="520B4D0807BDDA12" modified="2020-04-22" version="1">MRPITALRTWLAQGALTKVAIIAILLPICFANTLTQDDHAGTLVLRGNTPSKPTNSPVPDDDDYFRGAIHPSKYVRGENDIIRWAMSRGRFRASFTAHMYRSEDPALLPTVESVCQFLSVLQRRGNTFTAPGGSPDLNDDHYTVLQVDFELEGMWTEERLLEHLARKARGLYSAIVSKRTEGSEKLESNQWGPSDDWLSSQETKWAQQMVDKRLASFRELDLKVRVVDRTDPQRDSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U850</accession>
    <name>A0A5N6U850_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_147410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U850"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000787">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_2G16620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF195">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <location>
            <begin position="275"/>
            <end position="724"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="735" mass="81790" checksum="42A9D5145D55A113" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8D6</accession>
    <name>A0A5N6U8D6_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_135520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8D6"/>
    <dbReference type="OrthoDB" id="4509620at2759"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024956140" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="100" mass="11017" checksum="F409CAF231F03E40" modified="2020-04-22" version="1">MKIQLLAISLGALFAGSTLACETRSGTAKNCEWFGTAPTCGWTNRNIGDQVNEWTLVDWTKDKTKNTFCFAEDNGNAWGTCCDDYGSECIGGYKRLWCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8H7</accession>
    <name>A0A5N6U8H7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tricorn protease N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="DPP6 N-terminal domain-like"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025022695" description="Tricorn protease N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70760" checksum="AA242849B0F5D981" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8U7</accession>
    <name>A0A5N6U8U7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_146865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8155028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="442" mass="50903" checksum="E5D66AAB5C63245D" modified="2020-04-22" version="1">MTTVNVTLPSLPEGWTAEKDFKAVGTLSAATQRNLEPVGPHFLAHARRKRHHRTFSEDERIQAQQNVKKTEEEDDDLLSEDEDSMLLSREAKDWKSQDHYAVLGLTRYRWRATPDQIKRAHRKKVLRHHPDKKAALGDSDENDQFFKCIQKATEVLSDPVRRRQFDSVDEAAEVEPPTKKEAAKGNFFKLWRRVFIAEGRFSKNQPVPQLGDENSTFEEVDNFYNFWYNFDSWRTFEYLDEDVPDDGESRDQKRHVEKKNANARRKRKTEDTARLRHLVDDCAAQDDRIKKFRKAARADKDKKRLEREAEAKRLVEEKEKARLEEEQRKKDAEEAAKAEREKNKKVKEAAKNAAKKNKRVVKGSVKDVNYFAEGEASAAQVDSVLTDVELVMGKIDTEELASLAERLTAAGKDGAAVKNVYAEEVKRLVGAGKLKEGEAKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8W9</accession>
    <name>A0A5N6U8W9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_126220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8W9"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8155073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="528" mass="59434" checksum="B85896AD8B248F14" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U949</accession>
    <name>A0A5N6U949_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_63774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U949"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="62" mass="6886" checksum="111BCAA60F47E521" modified="2020-04-22" version="1">MMCPGNKRMMDQLLPDTGAYEGSFFFLLSVFCFFVCLIFNFQMCTCSCPQMGCGRSFVLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9Q0</accession>
    <name>A0A5N6U9Q0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9Q0"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8155342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="372" mass="40971" checksum="7BDC9FD68EDDD877" modified="2020-04-22" version="1">MNDHIPSRGSGHRVSCDLCRAKKVRCSGEYPTCSRCLTSRRQCVYSLQMPMGRPKMQRTMAKPPRSRRRGQQLSSNSSSTVRLHGELAVDTEPGTVLAESVRVDSQSTEQTGVVTPRPVGQIESAAALPSYLVDSDTSQRACTSLAHPGVYATSRSAIVDGPGSEPCACLSVLYLLLDRLRMKGEFALPDDLVLLRDSIGTAAGVLNCTQCPLRYLCVVQNATILGILCVCIAECYSKIMETIDADVRRAMDIQDTMQLRLSTVHDKGTYIGHTDPGHATSPLIIEVIPSEWRRLMRNAVKTEIFGVGNGKEKSFMQLIDGLEERQKGWHQTPPAPDCPPIYRSVCHLTDRKPTCLLIVEDAKRLINLLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCK5</accession>
    <name>A0A5N6TCK5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase activator Bem1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742930">
        <property type="protein sequence ID" value="KAE8144105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCK5"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000250">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="186"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="386"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50672" checksum="77D84BEA068DDC1E" modified="2020-04-22" version="1">MSAMAAMGMGKGSGAMVYGVVQYDFQAERPDELDAKAGEAIIVIAQSNPEWFVAKPIGRLGGPGLIPVSFIELRDMQSGQAVTDPLEAVRRAGVPKVEEWKKMTADYKNSSITLGKIDSAAAAAAAGSNNVQSVTSGMEKMSMSHQSVGHMSQNGNTYGQGYHHRNASKGSIAPHMSHQSMQSYHKPLMAPVAASIPRYCFDNDKYWYIIEAKMEDGRCWELSRYYNDFYDFQITLLTQFEEEAGNRGKPRTLPFMPGPVTHVTDAISNGRRQNLDEYIKNLLAMPPHISRCQSVRELFAPRPGDFEIDPSAFGEDVRFSGGSHHSSVHDVSRCASRQSTQASAAVDRTSHQRSQPSVSLGNGAPPPMNRQPSSLTQVSTTSSGGAMKVKVSFQGDLIAIRVPSDISLQQLREKLMDRLKVNDDIAVQYKDEPSGTYVELASDGDLDTAIQRNSKLTLFVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCN5</accession>
    <name>A0A5N6TCN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_3184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML743047">
        <property type="protein sequence ID" value="KAE8144093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCN5"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="54753" checksum="6A426AC54755A8FD" modified="2020-04-22" version="1">MARSFYPAKEEIGFDLQSKQDALSSPQPARTGTHQVTVDRNSSSITPPPEGESKNRNSTRRRIPVACSRCRKRKIKCSGDTGDGQGCSNCQSSGNTNCHFLRVNSSILQTKVSAWPYSTLNATLSPSHHGQETYVSPMALRPGALTAATPLNPRFASISRPPTMDMGTAEHHQQYNRSRFGVENTINYEDEPSNIYGSQPSVYMVPTTPQAFLTDYCGVSWPRAWNDASSVSRTPTGGLLPEHETESAFQPPGYPFLFPGAALQSNETAIVSSIASSPEGQGTDRTLPNPNGRVQPQVGYPQFPSSSPEIFLGGSQQECRAGHSWAHRGVPTNNPRPIQNYTAGVYRAGHLSRRRATVLLPNNQDLMYGALPMSSACTSSPLVSSTGQFAGTNMVDAGEEIRANEGPRAARPVMMDNARLPIVESDYSTYGYCSPEKIRRGHRTNDSTQPALLISGEMPYERPKGPDSSVPLTFDRVRGTEALSEIREATQGHRGQALSNQGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCT5</accession>
    <name>A0A5N6TCT5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742670">
        <property type="protein sequence ID" value="KAE8144198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCT5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="188" mass="19590" checksum="54FB7C255B2B6FA1" modified="2020-04-22" version="1">MSSNRPFLANFLAAFRAQSVYKASAASSQSATGGTSSSLSPSQQISQNARTIASKAGTSEPSPTTHYHHHHHHSSSATSHSRPHSHSRNPLNQSSPATADPQPSTSPPTTTASSNPIPIVNGPDRQRRGSDSSSGSGGFRDALGPEKWYIGGRTPGGEERFYRLGMVTKGGGRLGGSGRVGSIDQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD23</accession>
    <name>A0A5N6TD23_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_100597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742584">
        <property type="protein sequence ID" value="KAE8144288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD23"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="86" mass="9750" checksum="7550B2E81EF572DE" modified="2020-04-22" version="1">MLASFLVAHVPQADSGDFCVTTWRRCGLDIVKFFSHQCLQLNHLQRGSAFLHDLHLSLVSFLLFFFFLISFALGRGLYSVGALYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDC5</accession>
    <name>A0A5N6TDC5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742577">
        <property type="protein sequence ID" value="KAE8144302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDC5"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="392" mass="43987" checksum="AB4DF9F549FB9E3B" modified="2020-04-22" version="1">MEHRQSRADPEWMPFRPLHEQDPNDKMWLDSIPPTQPLYDMSQTYMNYNNNVNEVPAVFYNDMSIQQGSNNTRVRNGQPTPPLSHCAQSPPEQLVHSPDQVAEWPQPMSQDMMMMAPLNNHSGVCHPNMQMTMTPVNANMTTSPVKPNMTTTLVKPKRGAKREAQPEPEAATPPTKRRKSSDNKAKKPKTPPSEDREEKRQRALERNRIAASKCRENKKRKNLELQAEALAAEAKLKDLRESYEKYKAEALTLRNVVVEHGRCGDPGINSHVARMLDIIIVRNKAQAEAYAKAQAEAEGLDIMSPELSAYPDVVNTDAAAAAATSASPPAAQTQSFGFDDPFVSPGMENIDTLPFEDPIPQTDRRDSTQTLWTDDSYNISTEDAFEDYLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDL3</accession>
    <name>A0A5N6TDL3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_134727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742546">
        <property type="protein sequence ID" value="KAE8144377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDL3"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="125"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="521" mass="56681" checksum="4DA5DEC016EAF7AA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE76</accession>
    <name>A0A5N6TE76_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HTAFII28-like protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_166490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742480">
        <property type="protein sequence ID" value="KAE8144597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE76"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="336" mass="35844" checksum="CCA9455111A8D9CF" modified="2020-04-22" version="1">MHPLRQTSFPTTIDTESRAFSDAGSVTGSFTGSLGGTSADGVFRNKKRGRKSKAEKEREREDAVRGDMRSSVDAEGSVRAGGTGGGGGGEDGDDDEDFEDEGELLGREEGATDTEAEKKNLALLVDAFNPLQSERYDLFKRAKLRKETLRRIVNHALSQSVPASVVTTINGFTKVFAGEMIEKARTVQAEWAEAHDQAAVAAFEAEEAAAEAKARASTTPGTATPGPATPGPPHLKQEPSRNNSPYPPTNASGTPVSVGPQQSFNAQPRLERIFKMPPNPHRGQLLPAHLREALRRYKRDGEGGGVGFSGLSMGNLGVRGSVTWNAGSVGGRRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE77</accession>
    <name>A0A5N6TE77_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal L28e protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_166579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742488">
        <property type="protein sequence ID" value="KAE8144550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE77"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="157" mass="17134" checksum="579F6CFE9FCB5ECC" modified="2020-04-22" version="1">MAAERQNVSSDLVWQITRTQNAFLVKRNSGGGSQFSRDPLNVQNKHSFKYAGYANTKAVGVQPTENGGVVVVTKKPSNPQQPAKNVVSVSYGPNASTRKIYKGVADRTAKYNYRADIREGAVSRVSAIRRSQKTKKDTPPQKPRGAQARKAADQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEE6</accession>
    <name>A0A5N6TEE6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_166401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742473">
        <property type="protein sequence ID" value="KAE8144620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEE6"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="102"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="227" mass="25543" checksum="D21516012E93B119" modified="2020-04-22" version="1">MLPVTRRAIPSAFNVRPHLAYIPRTQLAASLSTSPNKSATAIERQGHSSQALTASGKLRREVPLPSQEKKEGAMQYVLTTLDQVANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTSEALMYGIFQLQKKMRHTRITRMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEP5</accession>
    <name>A0A5N6TEP5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742440">
        <property type="protein sequence ID" value="KAE8144766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEP5"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="139" mass="14854" checksum="7A24A24CFF7EDCB1" modified="2020-04-22" version="1">MWKSNRTPVRTENAPPPAPFLSQAIIAGEMVYCSGQVGVNPTTGKMVEGSVQERTKQILRNLSAVLEAAGSSIHDVVKVNIFLADMGDFASVNEIYDSFFKDPKPARTCVAVKTLPLGTDVEIECTGVLAKGSSAKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEZ2</accession>
    <name>A0A5N6TEZ2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_165738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
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        <property type="entry name" value="LD21067P"/>
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    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
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    </feature>
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        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="907" mass="101728" checksum="350DFAEDC6D23580" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF50</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742408">
        <property type="protein sequence ID" value="KAE8144962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KAE8144962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="90" mass="10462" checksum="D8A3804ED98A99B4" modified="2020-04-22" version="1">MITNCFLLDTLIACTFVFSVSWLYRAVVCCRANASVVRNYIELSMVERLCFYRVCTHVGIVICSDITQQVIYHSEILYRSSRYITIGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF99</accession>
    <name>A0A5N6TF99_ASPAV</name>
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        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_165812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF99"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="194" mass="21341" checksum="9078FF2512C01D97" modified="2020-04-22" version="1">MFLQRTAFALARRAPVRAAAARPFSSSVIRSNKAKYAVEKEGKVLSFEEIKTEQDLVPPGAKAGSVPTDIDQATGLERLELVGKMQGIDIFDMRPLDASRKGTIDNPIIVNGAGDEQYAGCTGYPADSHVVNWLTVSRDRPLERCGECGNVVKLNYVGPEEDPHAHDHGHGHGHPAPEEPKTFADYVKPDYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFT4</accession>
    <name>A0A5N6TFT4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">BDV25DRAFT_165229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ML742376">
        <property type="protein sequence ID" value="KAE8145177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFT4"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="259" mass="29018" checksum="5B304DE0A5E8E0E8" modified="2020-04-22" version="1">MAAADDHIETGDLFQDPEGFYEPEPEPTYADHQMLSGQTVRVRLVGSHPLYGNLLWNAGRTSAHYIEEHAQDLIQGKDVLEIGAAAGVPSIIAAIKGARNSVMTDYPDPDLVGNMRFNAELSTSMVPSTSSLHVDGYKWGNPVEPLLAYLPPGSSGFDVLIMADVVYSWREHGNLIKTMQNTLKKTADAVALVIFTPYEPWFLPRTETFFPLAENNGFKVEKIFEKLMDAVLFENDHGDERLRRTVFGYKIKWKEDQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFX0</accession>
    <name>A0A5N6TFX0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAPP II complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_165564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742400">
        <property type="protein sequence ID" value="KAE8145019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="426"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="758"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1486" mass="164512" checksum="B6AA699D225E69E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG84</accession>
    <name>A0A5N6TG84_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742385">
        <property type="protein sequence ID" value="KAE8145111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG84"/>
    <dbReference type="OrthoDB" id="2730619at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043750">
        <property type="entry name" value="DUF5695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18951">
        <property type="entry name" value="DUF5695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024982865" description="Six-hairpin glycosidase-like protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="98121" checksum="42E53058995FC7E4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH70</accession>
    <name>A0A5N6TH70_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_164008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742318">
        <property type="protein sequence ID" value="KAE8145728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH70"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="226"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="703" mass="78500" checksum="F3C99F4DA25B953B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THX0</accession>
    <name>A0A5N6THX0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor PAP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THX0"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="580" mass="63143" checksum="44646E3B0D988F62" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI08</accession>
    <name>A0A5N6TI08_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_170164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742303">
        <property type="protein sequence ID" value="KAE8145890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI08"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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            <end position="480"/>
        </location>
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        </location>
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            <end position="608"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="608" mass="63743" checksum="6CD0064B5A87FF84" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIJ6</accession>
    <name>A0A5N6TIJ6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_55181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8146165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIJ6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
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        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
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            <end position="323"/>
        </location>
    </feature>
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            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="423" mass="47941" checksum="A57F6509A0DAA779" modified="2020-04-22" version="1">MNVNRKFDRFKQWAGERMGGEVKTNLSDDFKAMETDMTVRNEGLDRLHKSMVAYVKSVSKRNEGDDREKTLPIGHLGTSMVSHGEDFDANSDYGRCLTIFGRTEERVARLQESYIAEANSSWLESLDRSLAQMKQYQNARRKLDSRRLAFDTSLSKMQKAKKEDFRAEEELRTQKAKYEEANDDVYRRMQDIKDAEVESIADLEAFLDAQLTYHERCREVLLQLREDWPARQSQSQAPRRPGRTRANTVHSYQERYEPLHEEPSNGADVRPIIRTSRSPSDLADSRDVYASESVPQRPFLNRTSTFEGPGQLRQEQLYSSSPRPSRVISENFVPGRNSVLARWNTDSPEDASPRSGTSPDRSYQGRSDSPASSHGGVTRRSSSTALNGGALQKKAPPPPPPSRAKKPPPPLPTKKPIYSTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIM8</accession>
    <name>A0A5N6TIM8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pep3/Vps18/deep orange family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_58913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8145961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIM8"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="618"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="852"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="958" mass="107617" checksum="C2936CCDD9032013" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIQ7</accession>
    <name>A0A5N6TIQ7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_53704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742275">
        <property type="protein sequence ID" value="KAE8146254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIQ7"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="13">
        <location>
            <begin position="84"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8146254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122119" checksum="35995A49366FCCB9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIZ1</accession>
    <name>A0A5N6TIZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_52284</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="ML742269">
        <property type="protein sequence ID" value="KAE8146344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIZ1"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="20">
        <location>
            <begin position="81"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="21">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8146344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="281" mass="32131" checksum="3F9BC82AA117D397" modified="2020-04-22" version="1">MPGDSPGLEDQSAAAATIASESQLGKSGKRDAFAELLAPKPKQAKHTKDVQSRDHSNKRAIGGPRDGLGAYIANPEAYPASVVVYYNNDFVAIHDLFPKSTLHLLLLPRDATKTRLHPFDALEDPVFLNKVKAETKKLRTLAAGELRRRYGKYSEQDKERQRALNADPPPDKLPPGRDWEQDIKCGIHACPSMNHLHIHVISVDRYSDRLKHKKHYNSFSTPFFVPIDDFPLAKDDVRREPTKEGYLRRDYICWRCGKDFGTRFSELKMHLEQEFEEWKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ43</accession>
    <name>A0A5N6TJ43_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_162560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="ML742265">
        <property type="protein sequence ID" value="KAE8146394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ43"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="36369" checksum="3288479986C7607D" modified="2020-04-22" version="1">MPGLPASIDLDECIERLYRKELLADSVIEAICAKAKELLMKESNVVHIAAPVTVVGDIHGQFFDMIEIFKIGGFCPNTNYLFLGDYVDRGLFSVETISLLVCLKLRYPQRVHLIRGNHESRGVTQSYGFYTECARKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDTERDEFSLSPRGAGYTFGAQVVRKFLEVNSMSHILRAHQLCQEGYQVLYDDRLSTVWSAPNYCYRCGNLASVLEVSDTGERFFNIFDAAPENDIHRGEQQAQQSKDGQNPVIDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ68</accession>
    <name>A0A5N6TJ68_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_51628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ68"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000356">
        <property type="entry name" value="Translation initiation factor 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="503" mass="54524" checksum="B4C00F3C1E5DC33F" modified="2020-04-22" version="1">MAPAKQKAQKMSISTFLADENYGSWADEMDDMPLPAAPQLSFGSDRRAGGPPSAGFGNGFGERERGGYALREPLPLPTQPPYTAHIGNMSFDATAEDVSGLFVDCGVTNVRIVEDKLTKAPKGFGYIEFETVDGLKKALDLSGATLQGRSIRVSIAEPPKERDVKELDWTRRGPLPAPEPRRVPDRSSFGRNLDTFSDAGSERGGARRNFESDGKVRDFGNWERKGPLSPTGPVREGGRPRSNEGSSFRRSSPAWGEGRSQDGSRPPRREFQERAPTAAELDNSWRSKMRPDQPKEASNPPSPAAAPASPAAPSRPRLNLQKRTVPEAASSPAANTGTGASPFGGARPIDTAAREKEVEERRQLALRQKKETDEKAKAEKPEKPEKPEKSEKSEKPKPAKEQAKPEKASTLDPNGKDTAETPQGGTNFEILRRAGEDESGMTADQDQTEEAAAAAAKNEEANKENGSWRRGPAQPAEAADDEGWSTVSTRQRNNRRGAGRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJC9</accession>
    <name>A0A5N6TJC9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742280">
        <property type="protein sequence ID" value="KAE8146201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJC9"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="334" mass="37949" checksum="394825BEDAE7E587" modified="2020-04-22" version="1">MNILQPYNATDMNLSTAEYLAPFAPDQDHELYLASGKCHPALAASLVLSSRSTPESGISLSSHTPSAHPSMRSLPQQQHMYTPPTYQHYTLSDISDLADMIPYSMERVHLREPELENYIFSHSASQQFCRQGLESQQIMAAPEPFHPTSVPQTDYFPPQQDWASLSSAHRLSPEYYSEPYFTPRPPSSVTAGATPMSQPAMHSSSPSRSIPTSTSLDLPHQPQLSNQKDLTNYGILNPDLTWRCAYPGCSSQTIFRRGCDLRKHYNRHRKYLFCRHKGCPQAVQGGFSSKKDRDRHEAKHNPLVPCEWDGCHRVFSRVDNMKDHVRRIHKRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKE0</accession>
    <name>A0A5N6TKE0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_132646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKE0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="512" mass="56176" checksum="BE5F259534B8EBE2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKL3</accession>
    <name>A0A5N6TKL3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_143285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKL3"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="142"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="61253" checksum="0679FADB9E623D35" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKV1</accession>
    <name>A0A5N6TKV1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_132472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742232">
        <property type="protein sequence ID" value="KAE8146977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKV1"/>
    <dbReference type="OrthoDB" id="5413793at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="353" mass="38842" checksum="66EC190BF79C2447" modified="2020-04-22" version="1">MSSVNHDESKVGSIIVCNTILIVVATVGTAVRLLVRSSLSGLGLDDGFCAISWALMFCLCFLCMWMTRYGYGRHYQSVHDVAEKNMFLKLDFATMITYLVGLATTKISFCLAYLRIFPGKTFRAVCWTVVAIVVAETIAEIFVVIFQCEPIHKAWDAGGTVKGKCLQLLSFYYISFAIRLATDIALFALPIPKLMRLNMGLGKRVGLICMFGLGVFIIVTSIIRATYLNSFTQDRTWELVETLNWSCAEVAVGIFIACIPSFKALIGIQFPKLARMLGLSSSKGSTGPTTYGVSTRKGDDYHRSIRMSTMPSRTKTDIEVSANGSEEHILPHSLAGIEVTTSVRVDRTDEGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKW5</accession>
    <name>A0A5N6TKW5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_161308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8146993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKW5"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="714" mass="76049" checksum="00830F80D10B6A5C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL23</accession>
    <name>A0A5N6TL23_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_169613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL23"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="35488" checksum="CA9201401C5C2E8A" modified="2020-04-22" version="1">MNTLLKVGQSLQGRRSMYNVTKQLHKSVWLARNDTGKPVLVKCTHQARITNERNVLKEFQSQTNCLRRLVDEIEEPANPPAIVLQHLDDDLSNASATQRLTTTEIKYVSKRILQALAVLHERGYVHTDVKLDNVLVNYGSISDGNRFTDVQLADLGNTVHVESKFCQDRDLIGAPLWRSPEAQLGLQWGPATDLWSFGTLVISLIWGKNFFIFKPNVPLEHDEYVLKILAKYHVYFGPYPPSYSDLADDETLAILSYIMDSVSPTDLRPFTNASKKEISTDDKEFILRIMKLDPRDRPTAKELLDDEWFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL97</accession>
    <name>A0A5N6TL97_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL97"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26403" checksum="81C1BAFAA4DA6BCD" modified="2020-04-22" version="1">MDTISTNSYHASCASDEEESQYLKRVRILRWVRLGLAILIAGLSIALVACEAVPFHHYRRTSAYEKVGLYLWPLNLDIRPAIALISCGSILAFSNITYITTALLPSPRAHIHKINLLAATTALIGFLAALAAVVFAIHLPGSHPPSGFSGVETLHSWTCKWKVKHGLLRHNLDEIVSSPPRHFGRDCAATKAAFVLMACVLGLEILMGAVAAIGAWLARSVEKKRAESEVLVKVESVAKYPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLA2</accession>
    <name>A0A5N6TLA2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_161550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="ML742237">
        <property type="protein sequence ID" value="KAE8146889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLA2"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000214">
        <property type="entry name" value="Aspartate--tRNA(Asp/Asn) ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF4">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="231"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="55151" checksum="7FDEFC32DEBCD59B" modified="2020-04-22" version="1">MITITMPSSKGTAISRVSNVMSPSSYDTKGQTLAFDARVDSFFPLDHSKVIHLNLRVKDKILRAIVKASAVAKVTWDTSQQLTAESIVRVTGHFAQHICDDEVRGNTAYATIYVSALDVIAWASADLPLSSSHPKKMLSHVDLEERLSNRILDVRYAASGAIFKLHSGMCQLVVEFLCSNNFHWIHTPRIITATIPGDNEYFHLPYFGKDAWLAQSSQHHKQMALSMDMQRVFEIGPVFRAEVKSRKSMRHVTEFTVLDIAMAFYDDYHEVVEMIESMLVFIFHELQRRPQYQKLIEVVQQMYPDVRPFRVGLNECGKVPRISFLEAKRILRDEIGLESDDHKNFTEQEEAALGQHFRVSPHRGKTDIFTIDQYPASLRQFNSQPNPDAPGFSNTWDTIVGGREICSGSQRIHSYRDLCDAMRAGVCGPPLDPDAEQWQPYLNAFRAGMPPHGGCGLGINRLLQSFLGLDDVREATLFPRDVNRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLX1</accession>
    <name>A0A5N6TLX1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_132169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLX1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="408" mass="45594" checksum="D5F0B4334C851F4C" modified="2020-04-22" version="1">MHHNTDILIVGGGAFGTSTAYHLAQRGYTSVRVLDRYAAPSLEAASTDISKIIRSDYNDPLYAAMGVESISAWRSWDILRDLYYVTGWILSAAHRSIPFVEGSIETCERLGVTGLERMTPDQIRRRFPLITGELDAWNVNVWNPTAGWAKSGEALGRMALAAQEKGVQYISGEGGYVRKMVYEGDRCTGVITEDGTTHNADMVIMAAGAWTPSLVDLNGQLTAKGHAVAHIQLTPEETQRYQTLPILDNLEHGYFLPAQEDGIFKLAHSQFVTNEATDPRSGITTSIPHTFGDNPEDDIPMEIEQTMRRNLRRVLPELADRPFCYTRLCWDADTVDRDFLVTPHPVLQVLGKYIVDLLEGCLDPAIVHQWRWRPDTASSKNLAHADPDMELKELSGWRGRKFHKSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM32</accession>
    <name>A0A5N6TM32_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_33776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742209">
        <property type="protein sequence ID" value="KAE8147412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM32"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024998251" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8522" checksum="F42C2C19E3A858DA" modified="2020-04-22" version="1">MQGQTGLLIAITCICHSIQAVTQHTPYHCSRSHDNIGHGLSVDVTVDFQNKSPFMMIMRFKKFGTWVQCGYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMT4</accession>
    <name>A0A5N6TMT4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_159791</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMT4"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000007">
        <property type="entry name" value="CaaX farnesyltransferase alpha subunit Ram2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="40311" checksum="A6E90C3F60246ACE" modified="2020-04-22" version="1">MSGKYSSDPEWASIQPIPLNDGSDSGAIPLATIAYSDDYLEATSYLRAVMAANELSERALNLTEDVISMNPAHYTVWIYRAKILFALEKDLNEELEWLNRVSLKYLKNYQIWHHRQVLMASRKCFPKPPPKEQDFLMEMFNQDSKNYHVWTYRHWLVRHFRLWDDPREIQDVETLLSLDVRNNSAWNHRFMLRFGPREGEPDGGMPNSNGPPSEKGKLAVVDEDLVDAELDYTKAKLVRAPENRSPWSYARGVLRASGRPLSEWKEFAQKFVQEKIEGDQVVDVEVKSTHALEWLADVYAEEGESASGQTDEAVRMLTLLKEKYDPIRSNYWDYRIRRIAGPSPVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN99</accession>
    <name>A0A5N6TN99_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_159517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN99"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="55" mass="6524" checksum="E3F126D82F513ADF" modified="2020-04-22" version="1">MARNQFSLSRYFCAFVWCKYALMGITPCIPRVYAIKTKRFKAPCKRMFKAHMSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNP6</accession>
    <name>A0A5N6TNP6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_25604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNP6"/>
    <dbReference type="OrthoDB" id="4206571at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="527" mass="60296" checksum="1C2800976DD95024" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPB6</accession>
    <name>A0A5N6TPB6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_142037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742171">
        <property type="protein sequence ID" value="KAE8148193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPB6"/>
    <dbReference type="OrthoDB" id="5308502at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="55288" checksum="D55925AC83230D6F" modified="2020-04-22" version="1">MTILWIRGVSPYQQGDNGTDVVINEVHFNRTALDSYNYRLYTNGTLSNGTNCFLAFQGFRPHLFAENGTVVSGTSCYAPINGIGQHASLGLAFAIMFAISIFFSLLNLRKHGRRYLAHDRRWNALGRRLRWFWLLFVAACGTISCFMSIDVDRNYLQSSPLTLQSVFYTLLMPGIMAAVWEAVRHWGVWQERQIYDRDAYAFSKASTRKRQEFLLPILFYIFTILNIILTIPRSWSPIEQQHSPEQTAQTARPVATDTRWRTASFTALAGTLIICYSLEHSVYRYKPHPHTATAQFLFYLHAAPSHFLVAIGLLGLKTGYAIASAFEWSLSPLKYDVHPGWLYGLGYAPVLLIIVLFNISGYCELNEDKALIAQRTDLQSARADDIGAAKPPPWWKKQRLRSFARDITGRMATPDQVEMEKYVELGILKPGDKDDPRVVMTRRTNGGSGEEGHGELPTQVVEFGDRPVGLVRESAEGTGEGRRERFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPI7</accession>
    <name>A0A5N6TPI7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_23197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-219 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPI7"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="330" mass="35564" checksum="FFF45F401C304D48" modified="2020-04-22" version="1">MSPPAAIFEPTVAPTGFKGKVVVPESAPLDAASQTKLLDHFGSKWDNFKFAPIRESQVSRAMTRRYFEDLDKYAESDVVIVGAGSCGLSTAYVLAKARPDLKIAIIEANVSPGGGAWLGGQLFSAMVMRRPAEVFLNELGVPYEEDVNPNYVVVKHASLFTSTLLSKVLTFPNVKLFNATSVEDLITRPSANGNPKETRIAGVVVNWTLVTLHHDDHSCMDPNTINAPIIISTTGHDGPFGAFCAKRLVSMASVDKLGGMRGLDMNSAEDAIVKNTREVTKGLIIGGMELSEIDGFNRMGPTFGAMVLSGVKAAEEALKVFDERQRECAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPQ0</accession>
    <name>A0A5N6TPQ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calreticulin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_158578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742166">
        <property type="protein sequence ID" value="KAE8148295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPQ0"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025096057" evidence="9">
        <location>
            <begin position="24"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="562" mass="61748" checksum="C3707796683C30BF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPU7</accession>
    <name>A0A5N6TPU7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_141877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPU7"/>
    <dbReference type="OrthoDB" id="4740316at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="195" mass="21870" checksum="73CD5724EB6BC09C" modified="2020-04-22" version="1">MPPITKLWLCTLKEGKSLTDPALTQLLADILTLCTSYTNPNTLSPMHAFYQVTNDPSHLFMITGYQCQELNTEADKAYAEKYLPRLFEYVRHQWLRQVEVDVREMPLDGDAVVCCSGPGSDSDSHCNSVEGGGKGVGGWDVWKMTQQGKQAGVVQGVRGSEPVGERIWVQVSPWEGSERVGEEHETFYLRKIMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPZ4</accession>
    <name>A0A5N6TPZ4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_131244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742161">
        <property type="protein sequence ID" value="KAE8148426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPZ4"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="641"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="993" mass="108125" checksum="53A124079EE5569B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ63</accession>
    <name>A0A5N6TQ63_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lysophospholipase</fullName>
            <ecNumber evidence="3 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_158227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="ML742160">
        <property type="protein sequence ID" value="KAE8148437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ63"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000024">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="157"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="710"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="822" mass="91450" checksum="FB34678B17B50AC3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ75</accession>
    <name>A0A5N6TQ75_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_131157</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ75"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="549"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8148516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="617" mass="66114" checksum="B600A1F6E81569DF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQE4</accession>
    <name>A0A5N6TQE4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_131161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:microtubule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026708">
        <property type="entry name" value="CSPP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21616:SF2">
        <property type="entry name" value="CENTROSOME AND SPINDLE POLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21616">
        <property type="entry name" value="CENTROSOME SPINDLE POLE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
            <begin position="726"/>
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    </feature>
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        <location>
            <begin position="177"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="86671" checksum="2A3E8F6F15139E86" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQK6</accession>
    <name>AVEB_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp enzyme aveB</fullName>
            <ecNumber evidence="2">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isoindolinone dipeptide biosynthesis cluster protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aveB</name>
        <name type="ORF">BDV25DRAFT_157925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="1106" last="1106">
            <title>A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <person name="Kjaerboelling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Petersen T.I."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J.M."/>
                <person name="Maekelae M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="de Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
            <dbReference type="PubMed" id="32107379"/>
            <dbReference type="DOI" id="10.1038/s41467-019-14051-y"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NRRL 4517 / IBT 18842</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="18923" last="18933">
            <title>Genome Mining of Isoindolinone-Containing Peptide Natural Products.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Wu L."/>
                <person name="Wang Z."/>
                <person name="Han W."/>
                <person name="Kerr T.A."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="40387549"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03321"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-grasp enzyme; part of the ave gene cluster that mediates the biosynthesis of the dipeptide L-Leu-L-Cl-Isd also called isoindolamide A (PubMed:40387549). Within the pathway, aveB catalyzes the last step and acts as an amide-bond-forming enzyme that activates the carboxylate of L-Leu for condensation with the amino group in L-Cl-Isd to give the dipeptide L-Leu-L-Cl-Isd also called isoindolamide A. AveB can also activate L-Leu for condensation with L-Isd to give the dipeptide L-Leu-L-Isd (PubMed:40387549). The alanine racemase aveF first catalyzes the interconversion between L-alanine and D-alanine. D-alanine is then activated by the NRPS aveC that transfers it to the PKS aveA to produce R-dihydroxymethyl isoindolinone. The flavin-dependent halogenase aveE catalyzes C-6 chlorination of R-dihydroxymethyl isoindolinone. AveG then catalyzes the gamma-replacement of acetate in O-acetyl-L-homoserine (OAH) with C-6 chlorinated R-dihydroxymethyl isoindolinone to generate the amino acid chloro-O-isoindolinone-L-homoserine (L-Cl-Isd). Finally the ATP-grasp enzyme aveB acts as an amide-bond-forming enzyme that activates the carboxylate of L-Leu for condensation with the amino group in L-Cl-Isd to give the dipeptide L-Leu-L-Cl-Isd also called isoindolamide A (PubMed:40387549).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>O-chloroisoindolinone-L-homoserine + L-leucine + ATP = isoindolamide A + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:85807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:234543"/>
            <dbReference type="ChEBI" id="CHEBI:234546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:85808"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>O-isoindolinone-L-homoserine + L-leucine + ATP = L-leucyl-(O-isoindolinone)-L-homoserine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:85783"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:234544"/>
            <dbReference type="ChEBI" id="CHEBI:234545"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:85784"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-grasp enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="2"/>
    <dbReference type="EMBL" id="ML742152">
        <property type="protein sequence ID" value="KAE8148646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQK6"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000462904" description="ATP-grasp enzyme aveB">
        <location>
            <begin position="1"/>
            <end position="662"/>
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</entry>
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                <person name="Daum C."/>
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            <strain evidence="3 4">IBT 18842</strain>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024814981" evidence="2">
        <location>
            <begin position="20"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="531" mass="58483" checksum="7ED082EDE6723EBF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR56</accession>
    <name>A0A5N6TR56_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_12424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:centromeric DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="493"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="629" mass="68838" checksum="FBFF2EC20CF1DD68" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR66</accession>
    <name>A0A5N6TR66_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">BDV25DRAFT_141590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742152">
        <property type="protein sequence ID" value="KAE8148631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="148" mass="15642" checksum="2B5E744593F89109" modified="2020-04-22" version="1">MDAIQLGIHLAQSIIAVIILGCSIYGLTISSTDGFGLAVVTAIATILVTVYIVTASFVAKGLYKVWLIIGANCVTGIFWLATVGKLAAEQTGGCGSHQHCYRKRDAGNHSIHAATIALSVIDCVLSVGCLVYTLYTKRNQRTKTPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TRB7_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_10201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742142">
        <property type="protein sequence ID" value="KAE8148906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="109"/>
        </location>
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        </source>
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        </source>
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    <sequence length="638" mass="72357" checksum="26CBE3FE6D3B2B46" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <accession>A0A5N6TRE7</accession>
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        <name evidence="4" type="ORF">BDV25DRAFT_157438</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="754" mass="83542" checksum="B2BF802C87A5B8E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRL6</accession>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_168109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF10">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025051376" description="NAD binding Rossmann fold oxidoreductase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="142"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38917" checksum="856DF22834127B80" modified="2020-04-22" version="1">MSSGNRRLKFALFGLGRLGVLRARILAFQQPRIELVAVCDTKPGTDKWAADNLPPSVMYFSEPQECLRNSGAEAVLICTATATHAPLILQALDLGLHVMCEKPVSVDIATTKEVVEKSASKPDLKFLVPFTRRYDKSYRQAKALIDNGDLGEIHAVETTGIDQADPNAFFVSFSEQSGGIFLDFGIHTVDAGRYLLDVKSGLSNPKKQVNRVIAFGQVAVYGDLAKFGDADNAWGLVEFANGKIFKTYLGRTLTSGFEDTTRLCGTKGHSIISANSNVEIRDHLGIRTQSVPDAFTLFDATFLTDLAEFADAVLDNKPMTCQPEDAFEAGKICAALQYSFRKGVPVYFDDNGLPIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRM6</accession>
    <name>A0A5N6TRM6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRM6"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="68" mass="7419" checksum="F20F03B08CDE12C3" modified="2020-04-22" version="1">MGGGGKIPYPKEVWSPAGGWYAQPANWRANTAVMGAVVIGIAAVTWSLSADRERREKMPEPGRFFPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRQ1</accession>
    <name>A0A5N6TRQ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_130905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRQ1"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="70"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="397" mass="44842" checksum="ADC4F1DD8C5B81F5" modified="2020-04-22" version="1">MNSVDIGRCGKRIAQYLWDPEPRNDADPEASIWCLGVEYPPHKRKNALLTTSSQDTGADTNDVTAHGWPEAFLLDFESKVWMTYRSNFPPIARPESRAPNYNMTLSVRLRSQLMEPEGFTSDTGWGCMIRSGQSLLANAMFMLHLGRDWRCGEKAEEEAHILSQFADHPNAPLSIHRFVQHGAKSCGIYPGEWFGPSATARCIETLSEECGNLSPKIYVTNDTSDVHEDTFMSVARNHRGDLQPTLILIATRLGIENVTPVYWDGLKAALQLPQSVGIAGGRPSASHYFVGTQGSHLFYLDPHTTRTALPFSDVSEALSKDISTYHTRRLRRIHVRDMDPSMLIGFLIKNEEDWEDWKRRIMATDGRPIIHIFSKRDIALRQSREEALDEVEALDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRY2</accession>
    <name>A0A5N6TRY2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742134">
        <property type="protein sequence ID" value="KAE8149113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRY2"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05118">
        <property type="entry name" value="STKc_CMGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000922">
        <property type="entry name" value="Protein kinase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="431" mass="48661" checksum="6773620595151791" modified="2020-04-22" version="1">MASILRALRNSIRRTRLSPREYSAIAHIIPAETPIEEETLPHYKAAHYYPVRIGDVYHARYQVAGKLGYGAYSTSWLCRDLQCAAPSPIDPGRALASGGSRAKNYAVLKVSTCLPDYPTATDRELRVYEHLAHIDSSHPGQSLIRDLYDSFDLQGPGGTHRCLVLQPMNMTLLEMMSMNPRPFDLPLLKMTIKRLLLALDFLHAEADVIHTDLKTDNLMLSLEDSSMLADFATAESENPSHRKLIDQSRSIYCSRRFRRPAKGRNYGLPVLCDLGEARIGKTQESGPFVQPHIYRAPEVIFEMPWGSAIDIWNLACLIWDLFEGQHLFGDIFDSGGGHDPFRHLALMVALVGPPPTEFVRHSETTEQCFDSSGDWIAHHEMSVPSVSLGALEKRLSGQEKESFLAFMRSMLKWMPEERKTAKQLLEHPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSM9</accession>
    <name>A0A5N6TSM9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_3344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSM9"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="922" mass="103793" checksum="457F0CE9768DF693" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT20</accession>
    <name>A0A5N6TT20_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT20"/>
    <dbReference type="OrthoDB" id="5398371at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56892" checksum="ACAAA077639EB842" modified="2020-04-22" version="1">MNPESLFGTGFSLQTPDPHEKQANNGPLKGTEPHIKALLKTGDVIIEYAPLGSNTSVSRESTSHRWQVLSDDLMNHSPYFRVLFDPNKFSEGKDFVQQKEKWGQRAVNGAEGPLSDDHIAHLPTIRLPVEHLPPDIGAETTELFLKILSFNSLGEEEQAKFDTELKIQPTSLITRLIELADAFNSLRVVREALNRSSYSFGKGRISLVKFNPSILRLSEDRIRQTIFIAKFLEQFTIFQIWTHALILLGSKSWVNGVEAPTSVATRWRYLSDGLEEEMYYRRQSILNTITDLQAYFLRAFGALEEQEAPKTASTSLTATAVQMRQYQCRCGFGNSSSCDAFHLGQMTRFFTLRTKTVFLGSTLIDPDFGLDSEDEETSDPPPPPPRDILTILSALKQCPDYQIDTNHNGCGVRRRFLPPLDCIEKFLGDARGLVGIELQDWDEKKWPHASSSWANRSLRRALALDVHLSRISSVARMSSGLSRPSSQEENARLLFTAKRRNWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT51</accession>
    <name>A0A5N6TT51_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT51"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="276" mass="31430" checksum="9C18CA942F2F1BCB" modified="2020-04-22" version="1">MPPVIHCVRHAQGVHNLCTANHVIHDPLLTDLGNEQCRQLRENFPSHDKVELVTASPLRRTMYTALQSFGPVFEAHKDTKLILLPEVQEISDVACDTGSDPDVLRKEIEENGLPVDSSLVYEGWNVKTGRYLPTHDAIRNRAREARRWLKARPEKEIVVVTHGGFLHYFTEDWEDSSQYQGTGWVNTEYRTYEFTSEIHKTDLEGRELESDNATMVETTPSRERRGKEGPAPDRETQKSFYKIGTKGWDDQGLQLSEAEREAAKVSEGKEVDGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTW3</accession>
    <name>A0A5N6TTW3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTW3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025027190" description="Invertebrate defensins family profile domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15977" checksum="E2A3A957D16C847E" modified="2020-04-22" version="1">MKAFSILLCLFATLAVAASGDHQEKDGSDLGFRDPTAPIHAPVIEQPEAEQEAARTEDDDEASGAQHEGDGEGDGEDDDNDEDDNDEDDDGQDDDSDEYDANYVKTRTLRLARRGKCSGGCRAHKDCKCWRTGDRCIIGICMGPALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUP8</accession>
    <name>A0A5N6TUP8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_155045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUP8"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000005">
        <property type="entry name" value="NADH pyrophosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="250"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="415" mass="45738" checksum="86E609C00CDE77B2" modified="2020-04-22" version="1">MTSHPQIPTPAHTQADSMLSRQFGRETVNYFSSSPLNRLSFLRGDHSFLSAAVRHPATRFVLLKDLAPLTKSPSELYYAHYNDIRKLVPETIYDKSEEDIIKEYDSRNTIPQLVFLGLDESRKQDGLAWKIYTGAPCFALDVTPKGSEEQQSNSKDVISALEAQGLSFLHARVVMTFSADEAAVYAQSRALVDWNNRNSFCGTCGHRTLSVNSGTKRACPPSDAARVAEGKPAERPACNTRTTLSNLSFPRTDPTIIVAVLSVDCKRILLGRSKRFPPNWYSTLAGFIEPAESVEDAVRREVWEEAGVTLSRVIIHSSQPWPYPANLMIGAIAQVSDPAHETINLSHDPELEDAKWFSIEEVEEALKVGTSALGDGPSAEYKEGGLRLPPPTAIANQLIQSAVSMDFLGDKTSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW13</accession>
    <name>A0A5N6TW13_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_110860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW13"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024882318" evidence="8">
        <location>
            <begin position="22"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="512" mass="54167" checksum="88A254F8D21BB553" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW61</accession>
    <name>A0A5N6TW61_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_107639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW61"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="38551" checksum="083EF357215623C9" modified="2020-04-22" version="1">MTVPDIPKQQRAAVRHGSGELATTKIETVDVQLPGPGQILVKVNWTGLCGSDKSLLQDDWKGFGISMRPETQGIAGHEGAGTVVAIGEGMHKRWKIGERAGIKWIASTCGDCDYCATGVEEVHCEKQINSGFSAPGTFQEYCVVDGRYTSKIPDGVSDEEAGPIMCGGVTSYVACKRSAVKAGQWLVLPGAGGGLGHLAIQYARAMGIRVIAIDGGDEKRELCQKLGAEVYIDYQKTKSPADIKDQIMKITTSGAHGVIVTAASKAVYEFAPMYLRPGGTVVAVGLPSDPTLLAGAPPIVLALRRLNIVGSITGSTKDVEEALEFTSRGIVHPILSKGKLEDLDAWVKKLKAGQIVGRAVLQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWM8</accession>
    <name>A0A5N6TWM8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_105675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWM8"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="542" mass="60499" checksum="C94AC44FD34C38D5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWP0</accession>
    <name>A0A5N6TWP0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_139576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8150664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWP0"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="90"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="240" mass="25794" checksum="C298D87F5007D3DE" modified="2020-04-22" version="1">MAASISYALSVVLYHASSDDDPRKYENNQTLSHGTAIASLCLYALLIWFRSSTHTHLFESRDLDGSDRSDLDDDTSSSEGSPVSLYAAGLVAILSITGLTACINVLASCTDSAAEATNLSKRYIGLILLPMISNIPRSLQTVALAWGGNMDGVIRLTLGSRLHLALFAWPVLIIASWAFSITMPVDQAMIEPVVLFLACLIIALVTQDGKSNYLDGFLALGMYTAIHLAIYVSPDYASDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX95</accession>
    <name>A0A5N6TX95_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX95"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="107" mass="12152" checksum="327879BC2004BCA6" modified="2020-04-22" version="1">MAQGSLVPLFILLAVVTVLGGVGYITWSIVQEVTRNTRTKMEKKNVVWSRDGMKVGVKELKDEDYKDRSQSVLVNMWNHTSFPAYKSRLWNMTGSANQGSEADKNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXA5</accession>
    <name>A0A5N6TXA5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_103720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXA5"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32809" checksum="39FC110E57039E73" modified="2020-04-22" version="1">MEQDYPIYQTLPFSMPRNRIAELLAADVMVAAGSASLITPAVMILDRLVVEKSSHNQPLLPAFRRHLWLSVTQPATFLTSRPSLLVWSLYTATFAAANVTETLLDRVYPNVDHAISGMATFMSTFVVNSSVGIWKDIKFAQLFGHSPAPKPAPTPAASPSPKLARVGRSIPLATYSAFLLRDGLTIFGSFSLPAMVSSSVPDWIASREYLKILFAQLAIPASIQLVSTPIHLLGLDLYNRPVAIPARDRMARVSRDWIGASLTRMCRIIPAFGIGGFANTEGRAFLHQQLQQCGDDENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXD7</accession>
    <name>A0A5N6TXD7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_153511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
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        <location>
            <begin position="565"/>
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            <begin position="565"/>
            <end position="593"/>
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            <begin position="1"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
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            <name>heme</name>
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    </dbReference>
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        <property type="term" value="P:secondary metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <sequence length="469" mass="52973" checksum="F97E20121FB738FF" modified="2020-04-22" version="1">MLANVATEVSSGGITAFVLIATVAVIVFGRSPKSALPVINGRKPWEVRYEHVRQRSLGNALSLIHGGLSKARAFLVGTESGYKVVLAPEYANEIRSHESLSFNQEIAKDFHPHIPGFEPFKQGLAPDSIVMDAIRIRLTQSLAWHTLALISSILQIVAQLSSKVFLGDQICRNPDWLRVTIAYTIDSFIAAEQLRFWPAFMRPVMARFLPCCRKIREEIHQARKIILPVLQRRKEEKEASIQRGKAPERYSDAMEWMELCAKGRPYDPVTAQLILSVTAIHTTSDLITQTLFDLCGKDNLIQPLRNEIVTLKLMDSVIKESQRLKPSSMISMRRLTTNDIELSDRTKVPRGTSLMVSCEKMWDQEMYPEPDTFDGYRFLRLREKKGHENSAQLVAVTPEHMGFGFGKHACPGRFFAANEAKVLLCHILLKYDFKLADGCTPRVLKHGVDMSADSTGRIDTRRRTQEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY83</accession>
    <name>A0A5N6TY83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY83"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="31985" checksum="65F076B8C2315299" modified="2020-04-22" version="1">MIAASSITSESSKLTMSSTSPITFYDIAMRPPVEKNACSPNPWKARLALNFKAVPFSTTWVPLPEVSNVRKSLKVPAIRKFADGTDFYTLPIIEDPNTNSTVGDSFDIAEHLQKKYPNSGSDLFPPQKLDYTFTFDLLVPLSDCRDSDYPEYAKFNQNVDAAFSAHVQLAVEKLPFDPATAEISRAEFVRRAGVSSWDDFALVGEARRKVLDSFRDTLGGLAKLFADPNEPFVLGKQASYADIIIGGWLRMMRATLPESEWEELRGWHSGRFGRLHDALEVYADMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYP7</accession>
    <name>A0A5N6TYP7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_138907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYP7"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="27605" checksum="58E2078FC2942EF8" modified="2020-04-22" version="1">MSRILTQSCFKQLSQSSLRQGSLPVFLAPAFSYPQRTQSFSTTSPTQSRVGGSSISVPPEVSLKFIDLPQVQVRGRAKDIPKTAIEVKGPLGQLTLNIPPFVAVAHDEALRKAVLSVQDSEIPHQRAMWGTTRANLQNYVLGVSEGHICILSLVGVGYRASVESTATTVEPEYPGQQFVSLKVGYSHPIELGVPQGVKASTPQPTRILLEGVDKSVVTQFAAEIREWRKPEPYKGKGIFVNGETIKLKAKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYR9</accession>
    <name>A0A5N6TYR9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxy-acid and 6-phosphogluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_171391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYR9"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="378"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="594" mass="63617" checksum="2E090376D176428D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYU7</accession>
    <name>A0A5N6TYU7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_138745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYU7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024811415" description="Choline dehydrogenase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="124"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="5">
        <location>
            <begin position="499"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="70381" checksum="B5BA98CF15328498" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ19</accession>
    <name>A0A5N6TZ19_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ19"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="27"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="158"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="35901" checksum="0BE124D3120C4285" modified="2020-04-22" version="1">MAKSHHIVDIEAVHCPISEFDIPGGYTLSAYKWTEQSDLASRIKHATIVLTTTIRIPAAVLSPEVTPNLRLIVIMASGTDCVDKEAAKARGITVCNCPGTNIDSVSEHAIGLYFAARRRLVGLHNTTVSVPEDITQDTEWKMHGGLNRMVRTADGEAPLTCEDETVGIIGYGSLGKRIHTLATSLGMDVRVAERKGEAPRPGRVSFEETLKSSTVVILCLPRTPQTTDLISTAELHLMSRQALLIHVGRGGIVDEQALLEALKGGVISGAAMDVYAIEPAGRGTTPLLGPDAAGLNLVMTPHLAWYSKKTLRNLEAATKTTVESWSGGNIINQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ40</accession>
    <name>A0A5N6TZ40_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_128676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ40"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="38914" checksum="A14CA689E09F9A53" modified="2020-04-22" version="1">MVSGRSETIVVVASVFLVLPLLAVILRCYVRWRLVQGFGWDDGFMVLAMVIHIAFQTCGIAGAVVGIGQPQSYFTDQPHAFSQALLLWWLAQDFYLFASLSAKISIIISICRLTIVWTHRILLYAIGAASLIVHVVMFFFLFFQCSPVSYFWNRQRMSGTCLPTSVLLPVAYTYSVTAAVCDFAMGLLPVMLVWNLQLGRRTKCMLAIILGIGCLAGVAVVVRIPYLHRYTNTPGDFLYVTYQLSLWSNIESGLGITAGSLITLRPLLRHLRDYVFQLRSRNSDSSSDSLPDAASKDGGPSNPTDDRSTRSDNPEEADEQLPVGYHRMLRSMHDSCGKLDRFDDILGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ98</accession>
    <name>A0A5N6TZ98_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_138914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ98"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
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            <begin position="156"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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            <begin position="54"/>
            <end position="67"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="268" mass="29758" checksum="E13D4AF095EA71E6" modified="2020-04-22" version="1">MADVRSLLRNELASRKGSNQTSKTPAARVTKKRKVDPEDDLTRKKMKHAIANADPQSANINTVQPPSAQALDEDIDLSEQDTAGPEPPSDTEPEQMAAQTQNQPLEEAGVASTKSAEGSQAVDEDEWAAFEREVAAPTRVPQAPAALAAAATISAAPVSAEQLAEQQKKEKETIARGREAEAEGEREDAARFLEDEFDEMEQLEERVRRLKHKREELRQMRATEERGTPPVDISHSAVSASEEKAQNDEEEDDDDDDDDDDWDNWRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZB7</accession>
    <name>A0A5N6TZB7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">BDV25DRAFT_152212</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZB7"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="275" mass="30535" checksum="DA7ECB310C97B0AC" modified="2020-04-22" version="1">MATHVLTATAAVPTNQISVYGHVSPVNTANSSPTSPRQQYLPLQTRQLRPPKGPLYVPAALRPTERPQKSSPPTPPRSVHGSLDSLNEVEEQPSLTRRSTIESAASGGISKLAEDEWMKHEHLGEVTGLPTRDHWKADSASPNCDSPTCRSSFGLFLRRHHCRHCGHVFCSSHTPYVVPLDQEARFHPEGVQSRACDLCWHAYQRWEESRSDRLSKIQNILDAQNRKPEEAEEPTAETVDHVVADEESKKALAAMLGQSTDIAASIPRGWNWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZE8</accession>
    <name>A0A5N6TZE8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_152261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="668"/>
        </location>
    </feature>
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            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="717" mass="80856" checksum="2410E995FE0F4A8B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZF8</accession>
    <name>A0A5N6TZF8_ASPAV</name>
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        </submittedName>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
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            <end position="51"/>
        </location>
    </feature>
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        <location>
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            <end position="102"/>
        </location>
    </feature>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="425" mass="48145" checksum="A47AC045D1EFC130" modified="2020-04-22" version="1">MDDNHKWTEAEDQILKAAVRQVEAPIDWLWIARHLPERSNKDCRKRWYQRFAGNTNFGSWMDAEDSRLRAAVARHGTKWPIISKEVGTRTSEQCSKRWKQVLDPNLDHSPWTLEEDNSLLTSVERHGRNWKMISEMYLKNRAALSLKNGYALLIRRRNRSKGMPQAMARMQTKSRSHSPRAIVMTEYQNNSQQLDNSAVLSDDPQLSEKELQDEAMTSNVEDDTVRSETAQYDWGDLDMATSSTTLGKGGYWSPDSNPFLSSSPFQSQMSNERPGIHDILGSPSCGPQSVTSMPQYNMTDFQGNLKHLFDSMSPLDNLPLDPNVSLGSTETSSGPSSGLSSGFSTRPSSVRVTAAPGMGEEQLSRPITPYRGEDWNNLFSLTVRCTKEKMEAIRQSVLETTSNMLCSEERDDDLIEMRFTVERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZN9</accession>
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        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="238" mass="27451" checksum="DCE296E4190D9420" modified="2020-04-22" version="1">MDFQNRAGSKFGGGGVASQSATNADRRERLRKLALETIDLEKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGRKHQTNLARRAAREQREGKNQDPSTLPGAMGVQVKKQTIKIGRPGYKITKIRDPLTRQLGLLFQLQYQEITPGVQPRVRFMSAFEQKVEDPPDKNFQYLVVAAEPYQTCGFKLQAREIDRREGRYWTWFDEDSKEFWVQIMFKTDREERFSGVPGLAPMDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZY0</accession>
    <name>A0A5N6TZY0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_80491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZY0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="93" mass="10415" checksum="45F59AA1CDFA8529" modified="2020-04-22" version="1">MNIEPIKEMSRFRGWPNPALLPSAEASATVMASPNIRIMLYDPVEGYYPFREYIAQRLTSSNPSTAFLPASESPVPPICMLQVFTDHLCARIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U151</accession>
    <name>A0A5N6U151_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_151336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U151"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="615" mass="69739" checksum="BDB70F879F5C00D3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U165</accession>
    <name>A0A5N6U165_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Luciferase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_170864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U165"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="361" mass="39959" checksum="B831AD06D802AC53" modified="2020-04-22" version="1">MPVEFISLTFPNASTELNPIPNAAIDPEYLKRYARNLDDYSFNYTLVPYHSSSFDPFTTGATIAAVTKNLKIIIALRPNTLYPTVAAKALATLDQLSSGRAVVHFIAGGSDADQASEGDFLNKGERYARLEEYIHILRRAWESPEPFDWEGKYYQFKQFSNKVRPTNGKSIPVSVGGSSDDAYRIGGSLADIFGLWGEPLKETKEQIDRIYAEAEKAGRTDRPRIWVTFRPIIAETEELAWAKAHRTLDALKGNRAPAQNGASAPPPVQNVGSQRLLDIATRGEVQDRALWYPTVTATNARGASTALVGSPQTIIDSILDYVDLGAELISIRGYDNLNDAIDYGRYILPQVRQTLQDRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1L1</accession>
    <name>A0A5N6U1L1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_138084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1L1"/>
    <dbReference type="OrthoDB" id="5213892at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="636" mass="70451" checksum="44944BF11FF5C8B0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1M3</accession>
    <name>A0A5N6U1M3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glucanase</fullName>
            <ecNumber evidence="15">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_151273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 6 (cellulase B) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="15"/>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1M3"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025075059" description="Glucanase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11 14">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8152289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="407" mass="43391" checksum="4F65FA7721F5E2DA" modified="2020-04-22" version="1">MQSINVRALWALSPLLFSAAKALPAASTTPTPSSSVPASSSPAPTASATGNPFEGYELYVNPYYKSEVENLAIPSMTGSLAEKASAAADVPSFHWLDTADKVPTMGEFLEDIKSQNDAGANPPTAGIFVVYDLPDRDCAALASNGEFAIDDGGVEKYKAYIDSIREIIEEYSDTQIILIIEPDSLGNLVTNLDVEKCANAQDAYLECTTYALTQLNLPNVAMYLDAGHAGWLGWPANIGPAAELYASVYKNASSPAAVRGLATNVANYNAWSIDSCPSYTQGSDVCDEKTYINNFAPQLASAGFDAHFIVDTGRNGNQPTGQSQWGDWCNVKNTGFGVRPTTDTGDELVDAFVWVKPGGESDGTSDSSAERYDAHCGYNDALTPAPEAGTWFQAYFEQLVENANPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1T8</accession>
    <name>A0A5N6U1T8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_61493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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                <person name="Makela M.R."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="89" mass="10353" checksum="FBED5AD5668254E2" modified="2020-04-22" version="1">MYRGLLLSFLRGYMHRQIRTHRTLYICPLGFRIAWRFGSGELLEIPFISAHIFARTLAIAIGNRHSYLPESEVDVVFCILLIGTGWRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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    <sequence length="123" mass="13970" checksum="8CB661312A9BA204" modified="2020-04-22" version="1">MPFVPTSAELQHPLAQEYQNNAGDLATAGLQEDASRRGRSGSKWGIEEVNAVRAVPLVHLDPTRIIPESYFPGDDNEVFYALVRHIRAATVDDLKEYDPDKFTHNPYLGFFKIPCRAWHNKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BDV25DRAFT_137514</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chovatia M."/>
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                <person name="Henrissat B."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="206" mass="23622" checksum="ED4316DF39E3F955" modified="2020-04-22" version="1">MENPEQEIPQIISTLTQTPPALQSRTIDKYFTPNATFVHPFCRIQSFDNSRWVVKKIYQWYKIMSPRIEMRVHSVALDKPNLKLYVTMSQVFTIWIIPFHIARVTLTTVLDLTTDPTGSSLPSGPKRGKEKYYISKQEDLYQTSEFVKFILPHVGYWIVVGMHAFATVFCVLGVFLWAPFVFLEERGLLGGLLGRGNVAGSVRTYI</sequence>
</entry>
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    <accession>A0A5N6U3U2</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="KAE8153307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="594" mass="65492" checksum="351897093DC8AB98" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <name>A0A5N6U5V0_ASPAV</name>
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            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="473" mass="52529" checksum="B30391E2EA39D498" modified="2020-04-22" version="1">MDSSKLRAACDRCHQLKNRCARSGGPESRCDRCERLDIDCIFRANARMGRPRGQRSHQRTSPASNSDGNQSTRNQTVFSRTQNRSMRETRRITTAKGEHLHHGDPESHSTPNHDTYGVTLAPTPPGIWDEDIIPDGCHMMDMETLGSEDTSPITASGPGLEWDFDLPVFHQPLQVNTGPKEDTLSSILASLPQQILLSDHYEGNLSPKQDLSSTTGSTNEPRYALDIKRLVELQNRLHGLMCSEHLCKDQGDFTPDTETNSHLPVDEVLGVTSSLLEILQATRGTDVNPSCESIQTAPKQESSKYLGVLHAVTCYAYLVEIVESIIPSLAMQIERSTNNTSPHAIYNLDPRLTGNITPVSEPTPDKPMNQRPILKLGCFSLESQPSLNAHVVLHIILRMIQELHVSFRLLISGPRATQRNACTEGELDFETDWKTKLEDTATGLAAQSIIREFQEKDTALLEKLRCLTAGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U696</accession>
    <name>A0A5N6U696_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U696"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009960">
        <property type="entry name" value="Fruit_body_lectin_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07367">
        <property type="entry name" value="FB_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="546" mass="62954" checksum="74835D6811A281D5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6D5</accession>
    <name>A0A5N6U6D5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6D5"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27020" checksum="5F96ED669728492A" modified="2020-04-22" version="1">MDSNEIQGRLALITGASGGIGAACSHQLAKQGVHLALTYSTNPTSINNLVSDLKSKHGDKHLRISTHKVDVGSPDQIEHMFEEIEAEHAQRPDILISNAGYGKRITNIWDIPLEEFDYMLNINLRASFILVKGVVEHMKTQRWGRIVFMSSIAAYGGGINGCHYAASKGGLTGMMKNLSSRLAEYNISVNDVAPAMIGDTGMVPDPAAVAETVATIPLKRLGTPEETANVVTMLVSTGYMTGQSLLLTGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Q0</accession>
    <name>A0A5N6U8Q0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_64322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8Q0"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024913887" evidence="1">
        <location>
            <begin position="16"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="707" mass="78300" checksum="102747C73C302C37" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U981</accession>
    <name>A0A5N6U981_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_135181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="8 9">IBT 18842</strain>
        </source>
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            <end position="24"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="482" mass="52675" checksum="E72E0C9551112739" modified="2020-04-22" version="1">MSRKLNYEAYTVGWISTLPCELNAARALLDEEHERLPSPPKDDNVYLLGRMEEHNVAIVILGPCGPCSASQAVTNLVRTFPSIRFGLLVGVGGGAPKPPHSSNPRMDIRLGDVVVSEPEDGQGCLLNYEAGVYENGGLVIRNHLNKPSKLLMQGTGIVKSDHMFRRGKMQEYIDQIASLADDMEEWELYKYPGRYHDQLFKSDCPHSGGDDCRSCDTEHGLEKRLDRRSDSPVVHYGCIASGSSVIRSAQYRDRLRDAWGVCCFEMEMAGIMDDLPSAVIRGICDYSDSHKNKTWQPYAAVTAAAYAKDLLRVITPENVSSQTETIADECHTKPAYGLSLLQFTPTLHGGHYAVSRLLHSRGINMSFAHDHLVKAASIGNIAMVNLLLAIGSFDLDRRGTDGSTPLAAAVAGGHRATVESLLRAGANPNIEFGGDRMTPLFLAILKGDEGIVDLLTSTKQIDLTSLKSEVLPIANDPNLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9R9</accession>
    <name>A0A5N6U9R9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_126032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9R9"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="94"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="607" mass="69981" checksum="D7742AC6E87A09B2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9T2</accession>
    <name>A0A5N6U9T2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_167741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9T2"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="44442" checksum="EB5AFAA8607248D6" modified="2020-04-22" version="1">MSEKRETPPPTDPLPPPIEPPPDGGLKACTQAVMGHLVCFNTWGYIASFGVFQSYYQTSLGVSSSAISWVGSVQVFLIFFVGTFSGRALDAGYFRLVYYTGVLLQLLGVFMTSLATRYWQLFLAQGICTGLGSGLQFCPVMGLVATYFAKRRVFALAFGLVGGAGGGMLFPGLVKVLLPIVGFGWTLRVLGFVMLATSIPAMVFLQPRLPPRKSGPIVEWSAFQEPAYVLFCVGMFFNFWGLYFAFYYVGAFGRSVGLSYSDSTNLIIVTNGIGVVGRLIPAYLANAYFGPLNTIIPLALGASIMMFCWAAVHSVGGLYAFAVLYGIFSNGVQGLWPSTLSSLTPDLSKTGVRIGMGFTVVSFACLTGPPLGGALIARSHGYIGAQIWGGLTFAMGALVLVAARVSKTGASWKVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCM4</accession>
    <name>A0A5N6TCM4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_172430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742840">
        <property type="protein sequence ID" value="KAE8144125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCM4"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="68"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="497" mass="55248" checksum="9F19F3FC2FB1DBC9" modified="2020-04-22" version="1">MAAPHTSEDLDRRGDEDRQSSLSDQLESSPDKVKDLENQRQYGTSDSDTDDVGRQIEMEAGNSIKYRTCSWQKTAALLFSEYICLAIMSFPWSYSILGLVPGLILTVVIAAIVLYTSLTIWRFCLRHPHVRDVCDIGQHLFFNSKIAWYLTAVMFLLNNTFIQGLHCLVGAEWFNTITGHATCTITFSFVTAVISWIFSLPRTFSTLSKVATFSAFFTFVSVMLAVIFTAIEDHPAGYTPEKGEPKVTAIPVPGTTFVAGVNAFLNISYTFIGQITLPSFIAEMKEPRDFWKSVTAVTVAEIIVFSLVGAIVYAYTGNQYMTAPAFGSISNEVYKKVSFTFMVPTLIFLGVLYASVSARFIFFRIFEGTRHKGNHTVVGWASWAGILAVLWALAFVIAEVIPFFSDLLSIMSSLFDSFFGFIFWGVAYLRMRREDYGPNFYKTRGVRGWLGFLLNVALIFVGLFFLGPGTYASVKSVVLNYEAGTVGSAFSCADNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD90</accession>
    <name>A0A5N6TD90_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742869">
        <property type="protein sequence ID" value="KAE8144119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD90"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="39058" checksum="BC2704EFEE3E3711" modified="2020-04-22" version="1">MLQAESSANAARNGLKPVTAGIPSDYELPWVEKYRPVFLDDVVGNTETIERLKIIAKDGNMPHVIISGMPGIGKTTSILCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRHKIIILDEADSMTPGAQQALRRTMEIYSSTTRFAFACNQSNKIIEPIQSRCAILRYARLTDGQVVKRLKQVCDAEKVEVTEDGIAALVFSAEGDMRQAINNLQSTWSGFDFVSGDNVFRVVDSPHPIKVQAMIKACWEGKVDAALDGLNELWDLGYSSHDIISTMFRVTKTIPTLSEHSKLEFIREIGFTHMRILDGVQSLLQLSGCIAKLCRINMKPQLFEPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEA9</accession>
    <name>A0A5N6TEA9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_166269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742457">
        <property type="protein sequence ID" value="KAE8144672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEA9"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="68" mass="7529" checksum="CC36FFB02D0D4DA4" modified="2020-04-22" version="1">MSLWSSYRSLSPKSKALFGVGMMAWASIGLWASPQVEGAMGMAPTKEEQEDLDRKMALRISRVDKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF17</accession>
    <name>A0A5N6TF17_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_165833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742417">
        <property type="protein sequence ID" value="KAE8144897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF17"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="361" mass="39196" checksum="5DD2FC7562DFFAD9" modified="2020-04-22" version="1">MLKKKTLYPPLHFWNSTPTSTPELSPTSSSSDSESDEDMDSSGSRPLSLTVPTGAFCPMRPTLDEVLANTAPAPYTLSAFMAYLSQNHCLETLEFTLEAKRYRETYDSLCHQLGQCPILIDCPESQHLRMLWQRLLTAYIIPGSPREINVSSEVRDDILQHANSAIPPSPEILDAAVKLVHELMEESIFLPFLNSYSTPSHILSMSEPLFPHEDDVTVVSGPGLDEHAVKRARSKGRRLSPRSSKDFGSPASSSGHSGRSNFSFSAMTSMGKSSHRPSGHSSSASGDCSAGLTDDSGSLQSLSTGEPMTPPTTPPSSDAHGLHLAHSPKHRTDNPWKKMGMKLGFKKRSGNGSSGSNKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF58</accession>
    <name>A0A5N6TF58_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742401">
        <property type="protein sequence ID" value="KAE8145005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF58"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024883393" evidence="1">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="138" mass="15129" checksum="215253FDBE4B7082" modified="2020-04-22" version="1">MKITLFLLTATSLASARHITRDTPQDLQGRGEAYTDCIMKLTDNAEAKITQNIPDATECIQNFKLDFTDCLQMYTDEAGEERAGHMVNCFNDKRADLGACMKSVGIREDEQAEVFGYLVEDLQDGLSLDPAVGCAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF95</accession>
    <name>A0A5N6TF95_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_134136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742396">
        <property type="protein sequence ID" value="KAE8145038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF95"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="72"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="47908" checksum="0C1677D4D1813CD5" modified="2020-04-22" version="1">MNWLKHLLFNSWLQLGYNNDKTHRTSPSPRTPKTSGFPILDSTPRIEEERMPAYDRGPFYPVKLGDVFVSRYQILSKLGFGANSTVWFGRDLHQHWYIALKIYIWGSENREVRVLKHLSGVKTHHPGSALVRRMIGEFEIAGPSGKHQCIVYEPLLTSLLHFQATLNSQSLPEDLLKGALQQLLLALDYLHTEAHVIHTDIQAKNIIIGSKDDSIYREWENEEEAEPSPRKIVGSSSIVYKSRPFLRKKGWSGFGMPLLSDFGEARLGDVHTGLIQPDIYRAPEVILGMRWTSKVDIWNVGVLIWDLFEDHHLFDGRAPNGNQSDAHLLAEMVAMLRPPQADFLRKSPRSPKYWDSMGQWKAAVEVPHCSLEESEEYLEGENKTLFMRFIRKMLRWDPEERQSARELLSDPWLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFJ9</accession>
    <name>A0A5N6TFJ9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_165298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">IBT 18842</strain>
        </source>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KAE8145197.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="264" mass="29786" checksum="3EB00E9383253F4E" modified="2020-04-22" version="1">MTSSRFNPAQDRKDRPHCEHDGQLTNDPTLSSYISKEPLIQLVHPFTKAIFVISSISLLLLVTNQIVRNGSFYAISHAFPFAKAINSIVAGHQCSLPTARYDLQTGKSMCYPSSGGVWMADLAPLELQQLGIDRFDSSPRSCAQDEEDRFCQKLRLLGGSWYHPQCADKLWNGSKCRTLHELEPTFAFRRWVGYPDEGGVWVLRKPDSKQIPPESLTALQNALTMEELCIVLQRLGAVFCKDIKRCQALNDLHEGPDHWPTNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFX8</accession>
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    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Mortensen U.H."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="MCP"/>
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        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
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        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
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        <property type="match status" value="3"/>
    </dbReference>
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        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
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        </location>
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    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="263"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8145278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="38125" checksum="A5526207C3EC3079" modified="2020-04-22" version="1">MTLDKHSEHAPFHPSSQAAPVIMPAGNTWIMDEATRNKLLKNYKTQVASATSTICATLAVTPLENVKTRMQTHNFKNVSQCVRYLWRTEGPRGYVAGALPPLASVTAVRVVNFSTYNAAKHKISDFVERMTGQSPLAIYNQPGSTPTISTLATFTTAGLFAGLITSPLACPFELAKNVVQTSVLVHNRAQASPDAVNDPSLRNRPRLGTIEAIKQIVQRYGIRGLYTGFRLHALRDTLGSGLYFSVYETVKQLAAKELGPDKSPFGGPMIAGAICSTVPWFCTYPLDTRKTRAQSVLLGKTKEVGEATVAVAKASMYKGLSIILIRTGVNNMILLSMFEYIKMRINQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG01</accession>
    <name>A0A5N6TG01_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_165055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742366">
        <property type="protein sequence ID" value="KAE8145262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG01"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="616" mass="69657" checksum="4DCCFF81568EDBA6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG79</accession>
    <name>A0A5N6TG79_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_72908</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742357">
        <property type="protein sequence ID" value="KAE8145342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG79"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000004">
        <property type="entry name" value="Putative RNA export mediator Gle1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8145342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="524" mass="60139" checksum="F947E1912B5ECFE4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGA5</accession>
    <name>A0A5N6TGA5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BDV25DRAFT_164887</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742356">
        <property type="protein sequence ID" value="KAE8145347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGA5"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="20">
        <location>
            <begin position="127"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="22">
        <location>
            <begin position="403"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="21">
        <location>
            <begin position="521"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="18">
        <location>
            <begin position="636"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAE8145347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="769" mass="85705" checksum="1E70BDF72862D5EB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGL4</accession>
    <name>A0A5N6TGL4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_164638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742343">
        <property type="protein sequence ID" value="KAE8145466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGL4"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="809" mass="90816" checksum="653CD43F8C91163D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGL8</accession>
    <name>A0A5N6TGL8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_133739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742341">
        <property type="protein sequence ID" value="KAE8145482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGL8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="501" mass="54514" checksum="6B1510388E0C2098" modified="2020-04-22" version="1">MPPYAQISQDDRDPGPVRRSLFRIYWLTAIVCCGGILFGYDSGVIGGVLTFDSFLRDFNATPDLQTRVSAIAVGIQQAGALAGCLAIWPVTNRYGRRRAMMSCSVIFCLGVIFEVINSHSLPIFYLGRVICGLGIGGSATVIPIYLSEMSPKDIRARLGSCYQFTFTIGILVSYWVDYGIQFRAPTAAQWQIPLALQLIPGALMGIGMLTLDESVRWLLVHGESARAWRSLVWVRSSSDASVAAEFAHIKQGIEADQRVTADFHLRELLAWPNARRLLLGIGLFTAQQSTGATAMAYFGPQFFALLVGDNHSLTLLLTGIFGALKVLSCLAFIIWVAERFGRRPLLILGAVAMSLCMVTTVFVVKASHTPTPTVTATTIPASSILTIALIYTSIAFYNLSWGPLPWPCATELFSTRIREPGVAVGVAAQWLTNFIWSSSTPYVLQGLGWATFLLFGLLDLSIAGFVGLCLPETAGKSLEDIDVLFDAASDKDDEESELIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH86</accession>
    <name>A0A5N6TH86_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_66672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742329">
        <property type="protein sequence ID" value="KAE8145610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH86"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="212" mass="23303" checksum="84E51478ACCFF616" modified="2020-04-22" version="1">MDPNMNSLLKWSIQNSTNQENGNSNANNNTPDAASRGLTPEMLSSLFGGPTDADLMKASMTALRSDEVDLENKLIAFDNFEQLIENIDNANNLEPLGLWTPLIELLGHEDADMRRMAAWCVGTAVQNNEKAQDKVIVFNAIPKLVTISTTDTSPTTRKKAVYAISSAVRNYQPAMDELMKHLPEGYPRGEKVDAGNMDAVDAIMDKLRAHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THL7</accession>
    <name>A0A5N6THL7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_163958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742316">
        <property type="protein sequence ID" value="KAE8145750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THL7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="55" mass="6168" checksum="A6E374A4C34BAEE0" modified="2020-04-22" version="1">MPSSLKRSHCGSGWIGFYLRSTPIVGFVTVNVGFRGDAIRIFIAISIELHEVYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI83</accession>
    <name>A0A5N6TI83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742289">
        <property type="protein sequence ID" value="KAE8146063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI83"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19033" checksum="2C7A97FC6DEA82CC" modified="2020-04-22" version="1">MDVFYAYTYSTAGWLSLQSLSLITAPKIVTTLLLEEARSASEMEVYFARALGFALLTVAVLTVMLTGSIPLSSVSEPVTTHDNDPKAPYAVPTLIVTSLFQGWSAFYAYTQYLSTGQTVFALGMTGYAVVAAIGLWCVLFASSNGKISRKTGADKRTAGFPFKNSEAAKKHAGKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TII2</accession>
    <name>A0A5N6TII2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_60290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742302">
        <property type="protein sequence ID" value="KAE8145911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TII2"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="361"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="443"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="719" mass="81067" checksum="1F1B5FAFF9F3ECD1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIL9</accession>
    <name>A0A5N6TIL9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_163145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="ML742286">
        <property type="protein sequence ID" value="KAE8146110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIL9"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
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    </dbReference>
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            <begin position="8"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="440" mass="49371" checksum="E0C58D616A33A093" modified="2020-04-22" version="1">MGFTKENAMIGIIGMGDMGKMYAQRLSMAGWRINACDKPDSYESLKSEFASQTGVTIYPNGHLVSRISDFILYSVEAGVIDRVVAEYGPSTKVGAIVGGQTSCKAPELAAFDRHLPSDVEIVSCHSLHGPKVNPKGQPLVLIQHRASDESLHFVENVLSSFESKFVYLTGEMHDRITADTQAVTHAAFLSMGTAWQANNQFPWEISRWVRGIENVKINITLRIYSNKWHVYAGLAILNPSAKKQIRQYAESVTDLYKLMIEGRREELKRRVKAAGAAVFKAGTEGQDLLLKDEVLDQFSLAKGPREESPPNSHLSLLAIVDCWSKLGIVPYDHMICSTPLFRLWLGVTEYLFRNPELLDEALDTAIDDKTFRPDDLEFTFAARAWSDCVSFGDFESYRDRFEKIQTYFAPRFPEAAQLGNEMMKTILEKTMSNEAPESKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIQ5</accession>
    <name>A0A5N6TIQ5_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_54531</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
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            <begin position="172"/>
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            <begin position="24"/>
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        </location>
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            <begin position="175"/>
            <end position="188"/>
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            <begin position="544"/>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="KAE8146226.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="583" mass="64997" checksum="78CB252CB2A3EC72" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="9">PQ loop repeat protein</fullName>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8146547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="89"/>
            <end position="116"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31588" checksum="6D68DF98F6D43A00" modified="2020-04-22" version="1">MDLSSQCKHLISPNYMNFALSILILFGILLSYLPQHHRIISYKSSYGISPYFVLLGTTSGSSALANVLSQQQSLQDMSCCSDVNSLGCFAGLLGIFQIGTQCLCFFAILFLFVLYFPRDTDSSLPTTSKPKTEGPTFRTALIVAGVCIIHIMVMIIATITIGLKRPSSLQSWSNFCGVLAAILSSIQYFPQIYTTIKLRCVGSLSIPMMCIQTPGGFVWAGSLAARLGPEGWSTWGILIITASLQGLLLALAIFFEYLGPNKGHGHGKDADDEREEESHPAEDTPLLQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJP0</accession>
    <name>A0A5N6TJP0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_162176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
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</entry>
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    <accession>A0A5N6TK45</accession>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Wiebenga A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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            <end position="327"/>
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        </location>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8146461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="667" mass="74513" checksum="D8E551557E243C8D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKP4</accession>
    <name>A0A5N6TKP4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exosome complex subunit Rrp46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_161495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742235">
        <property type="protein sequence ID" value="KAE8146924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKP4"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000036">
        <property type="entry name" value="Exosome complex subunit Rrp46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26221" checksum="BE98ACFF5F05FDF6" modified="2020-04-22" version="1">MVGPTATLTPLSRADGSASYRCPSTGSNILGSVNAPVELPARRDALRPEDATVEVFVKPGTAPGGVGERYIENVIKNMLAKLILGREKGYARRGVVITLATIGGESVGRGDSYLTLLPALIHTALLALLSAAVPLSMTFSATVLAVNASGEITREPSEKEAAAATSLHALAFSSKGHLLLNESQGAFDFDTWEKVHARALAICHGTLTRTSDGDVAMAEDVDGQPLEGTVRETVEDKLHQDYAWKTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL21</accession>
    <name>A0A5N6TL21_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_132424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL21"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="351" mass="38642" checksum="ACADE6247015B590" modified="2020-04-22" version="1">MTQQKTIAVVNATGRQAASLIRVASAVGHHVRAQIHSLKGIIAEELESLPNVTLFQGPLLDNVPLMDALFHGANLAFINTTSQSGDEVAIGRALADAAKRAGTIQHYIYSSMPDHSVHGPWPSVPLWAPKFTVENYIRQLGLPATFVYAGIYNNNFTSLPYPLFQMELMPDGSFEWHAPFDPDTPLPWLDAEHDVGPALLQIFKDGPKKWHGHRIALTFETLSPNQVCAAFSRALNRPCRYVHVSKVEIKVNIPPGYQEELEAIEEIFGRCNAPYFPQPEFSRPAAGSPKGLGPANGKGAGAGMMQGPGGVISLIVTDEARHLWEGWRDMEEYAREVFPVEEEANGLDWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL51</accession>
    <name>A0A5N6TL51_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_161145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742227">
        <property type="protein sequence ID" value="KAE8147068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL51"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="165" mass="17670" checksum="FAA4D53DE2C851EF" modified="2020-04-22" version="1">MTLLRITVIRPHTIILYLVSGLTILVGGMFVLVSVFECTPVDFFWNRQTKTGKCVQPIALVGIAYAASVIAAIADFTLGLMPIFIVWNLQMNRKTKVALAGIMGMGCLYVLPTSSPPPLSYPLLTQHTAPAPPSSPASHTCPLTNTKTSCTPPTPCRSARTSKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLD8</accession>
    <name>A0A5N6TLD8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742222">
        <property type="protein sequence ID" value="KAE8147167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLD8"/>
    <dbReference type="OrthoDB" id="3029913at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1091" mass="122910" checksum="26A94F120CD1ADAB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLX0</accession>
    <name>A0A5N6TLX0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_161117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742226">
        <property type="protein sequence ID" value="KAE8147091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLX0"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="213" mass="25306" checksum="0476709600B6EF77" modified="2020-04-22" version="1">MVYYFTSNVVEPSAFIYVGKDKFENEDLIKYGLDKDVWFHVDNLSSAHVYLRLRDGESWDNIPQPLLDDCAQLTKANSIEGNKKDNITVIYTPWSNLMKDGSMATGQVSFHNQKLVRKVFVRLRENVIVNRLNKTRVEKFPDFRADKEEYLKKKQKEERKNREGQRAKEKQEKREREQLKWQKEHAYDDLMSEENVQGSSNQDRDPDFLDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM91</accession>
    <name>A0A5N6TM91_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742218">
        <property type="protein sequence ID" value="KAE8147229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM91"/>
    <dbReference type="OrthoDB" id="3852249at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046486">
        <property type="entry name" value="DUF6579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20219">
        <property type="entry name" value="DUF6579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="41798" checksum="39FB97A44EE6A7EA" modified="2020-04-22" version="1">MSAPLKLLLFNSRRPASQAIADKMMLFEQRKKKAIELANQANDTLKTIQAVGEAFGKNLNISNEAVSRVVETIKIAANSFGDKAIYATSFTSAVGAVGIVANAIATYQGVGELRAIAGHLKNISDTQRAELALAGGAAFAENIYVMVKSKIEKSNSDLDWYFVYHPDTDWTYHFEEKLRTKGTLGRNFIGIVHDLDAMVAFMLSVRDVYSARHPRREPPFFHLLIPAYEPIIIPTPLLIPEKLHPFRIEGDIHRGNSLVWMNLPGVDEKFVQNIGVFAPPRTIWDNIMVQVGLVQTPPPRFLGSSSKRIDETPQLPAPSAAPAVEPPEEEASSIKASRGSIRRASTYAPSDVGSTRSSHSHSHRRSRRHRSNSVSYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TML2</accession>
    <name>A0A5N6TML2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_132000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742202">
        <property type="protein sequence ID" value="KAE8147557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TML2"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="335"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="818" mass="90201" checksum="4391E7A80C6F40D3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMZ7</accession>
    <name>A0A5N6TMZ7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_159656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMZ7"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="244" mass="27351" checksum="AFF50386EDB660C5" modified="2020-04-22" version="1">MFQRTILRQAQAARSLLSTRSTTTAPLAVRRTSQLQPQSLRPLARFPAARSYSTENKSEETKPEEKKENGAAETDDVASKLEKKEKEVVDLKDKYVRSVADFLNLQERTKRDMDNARNFAIQRFAVDLLDSIDNFDRALLAVPEAKLTSDSPEHKDIKDLVSGLKMTQNILMNALKKHGLERFDPSDPAEDGSAQKFDPNRHEATFMAPSPDKQDGDVMYTQSKGFTLNGRVLRAAKVGVVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN49</accession>
    <name>A0A5N6TN49_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_131809</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="ML742191">
        <property type="protein sequence ID" value="KAE8147778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="555"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="1252"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1159"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1557" mass="174601" checksum="D3B6145F4A04FD4C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN78</accession>
    <name>A0A5N6TN78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_131770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN78"/>
    <dbReference type="OrthoDB" id="3438016at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025065968" description="Hydrophobic surface binding protein A-domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="13994" checksum="B3843E7DFD91ADDD" modified="2020-04-22" version="1">MHLIKYFILFSPLALATPNPNPVAAPAPESTGGGLLTELPQILEAVKDLLNPDTLDDLQTIVKGGAVLLGGDTPKNLQKLLSSQNIDKLQSLVDNADALLTPSFVNDTSTLIEDATPLVSNVSKLLGGLLGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TND1</accession>
    <name>A0A5N6TND1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_131761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TND1"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="347"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="508" mass="54710" checksum="55A75DDE933351C9" modified="2020-04-22" version="1">MGSISSTSPVVTRAGTPYFTPANSAGAAVNPNDPKTPTLFRPLRIRDVTLKNRVVVSPMCMYSAESDPTSPFVGALTDYHIAHLGHFALKGAGLVFVEAQAVLPNGRISPNDAGLWQEGTESEHQDAKVAVQLAHAGRKASVAAPVRVDESAGGWPKDVGGDSYWTPRALSTAEIKDIVRAFGKSAALAIEAGVDVIEVHAAHGYLLHQFLSPVTNQRTDEYGGSFENRTRLLREVGTPLFVRISATECWDIDSSLNLVKMFPELGVDLVDKIQLHTNYQVDLAGRVRKAIRDAGASTLVGGVGFITEAEQAQGIVQGADEAHETEALLSGPEPKADVVLLARQFMREPEWSLPLNYDRYIPWTEEKGEITACGIPINYNASKEWADKKVVLFAVPGAFTPTCSVNHVPGYIKSLPQLKEKGVQVVAVIASNDAYVMSAWGKANQVTNDDLLFLSDPDAKFSESIGWSNGPRTGRYAIIIDHGKVSYAQIETEKGVKVSGADAVLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNG3</accession>
    <name>A0A5N6TNG3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_159913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNG3"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="96"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="325" mass="36690" checksum="D5AC25865DD20181" modified="2020-04-22" version="1">MALITHEPHAGHSSNLIATFRLSQQAPVLLKQQLSKERNVLLSLVNKSEEPENHGMTEQLFFACLQSGDDKSAVLCLELLTRRFGSSNERVTALRGLYEEALAENQFELEQCLHKYDALLSDNALNLPISRRRIALLRAMSRPADAIASLVELLKAIPTDAEAWCELADLYHSQGMNLQAIFSLEEALLITPNAWNIHARLGEVLYICACPLDTEDSIQLLRRSIQYFCRSVELCDDYLRGYYGLAMATFLICSRNPSTGSSNELLSVSTEDMLYNNRVEKLNKLAKTKLEDIVERRSVDLQLWEYSQGELIAAKELLDRMTGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP00</accession>
    <name>A0A5N6TP00_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_131535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP00"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000201">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF17">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119221" checksum="EC290FDA84C4EABF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP96</accession>
    <name>A0A5N6TP96_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_159282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
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                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="386" mass="43195" checksum="83564B155D529FAD" modified="2020-04-22" version="1">MSSNKFDVSRIVRILRSDDPGSYVLLQVTPVGPGALDLDIAATEGENPYSGSVRHSRLRELCNMNYQGEDREWAQIVSYVFDCPEESAAKSDLLPGIESSASVVESADGESMELIITIRKRIQSITQRLGSLILKQDDEQAIHLFEWSGVAVARMNAVEQRFYSLLARYRSAEDTIKQLNKQLEDFIYAKDRHEDQILVNLVQLLNEKKLKIRNQQRILASANVDVERVSEIQDATLGRHCQLSGKGKQAKSAFRGASNSEFESEDGFDEMQVDQKPRSNEHQFNSETEDEKHSIPQSLEEIGADTTSEEGTPASLAEASSRSKTEKSKPNGSYGRSIMEQTVPHPPRRVLPFANRTQSSKIVLPQAQQQEDLVHVSTGETDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPJ0</accession>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPJ0"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024908910" description="Secreted protein" evidence="2">
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            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="7905" checksum="AC2C4BA1DEFF91F2" modified="2020-04-22" version="1">MVFVPIIIVGCTFAVALACSGACSRPQTHWVYCMAPRNPGNPRPSGEPPVTPPTLEPLPKGEPAKKEPALGQEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPR5</accession>
    <name>A0A5N6TPR5_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <name evidence="8" type="ORF">BDV25DRAFT_168531</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148343.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="531" mass="60042" checksum="C89A3D6888FC3BA8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPZ1</accession>
    <name>A0A5N6TPZ1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_20937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8148199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
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        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
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        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD_PCMH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="35"/>
            <end position="511"/>
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            <begin position="72"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022827"/>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAE8148199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="56166" checksum="EF54B9FBB970F25D" modified="2020-04-22" version="1">MQFLSFLSSISFGMTLLCAVFALLVAFLNSTGQATSSSSCCAALQSALQSQVFNVNTDTYQRSVESYWSLDTQLRPACIVQPRNPQEVSLAVTTLVTTNDQSPQCQFAIRSGGHSAVPGTSNIQGGVTIDLSLLNSTVYHPDKGFASIGPGARWESVYKELKQYDVTVTGGRDATVGVGGLITGGGNSFFAAEHGFGCDNVVNFEIILANGSLINANNSTHADLWKALKGGSGNFGIVTRFDLTTFPHKYFWGGMVEYDGFTTPQQISALVDFTDRIAEDRYASLLPMYRYDSSSDFNRVAVAMHYTKPEAFPSAFQDFYRLPNISSTVRFDHIYNFTREMSPLAGLHHILLTQTFINDARVVQKAIELQNHYISEAKAKAHGNDWTLISLFQPFPAVFGQLAKHKGGNMLGLDDENNHILYLLGYSWDNTADNDLFNSIGYKVFGEVQSYAKELGVDGRYVYLNYAGKGQNPLQSYGEDNAREIARVAKTYDPQGVFQRQVPGGFKISMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQA6</accession>
    <name>A0A5N6TQA6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein acrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_158585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742166">
        <property type="protein sequence ID" value="KAE8148301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
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            <begin position="108"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <position position="1013"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148301.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="108964" checksum="4DB7D320EC879609" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQH4</accession>
    <name>A0A5N6TQH4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nitrogen regulatory protein areA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_158405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8148371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF338">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="193"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="163"/>
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        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8148371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="306" mass="33355" checksum="C35181ADDEA2B95C" modified="2020-04-22" version="1">MMATTLADQKRPQLQPVCQNCGTSTTPLWRRDELGSVLCNACGLFLKLHGRPRPISLKTDVIKSRNRVKTAGQGPKRKSNGGVDGNGLTGSRSEAGTPPLGAHGYRRASRKMSPGHSDRSNSPVSRTETPGISSMQQSQLPPQHNSNIAPQHMFDSVTLGDHSLTNGIPSGQLRQPSPTSTSAAVDRHAESPQTVEGLLAANTSLKTRVRELEFVNDLFRGRVTELEQSDAAARRSEMIARDSESRVKRALEETQRREEDLKRRVSELERQVAEQANHGIAEGNDSPGEPLAKRMRLSDVGSNDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQW1</accession>
    <name>A0A5N6TQW1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_157774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQW1"/>
    <dbReference type="OrthoDB" id="4940293at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="308" mass="34367" checksum="B3DA2083DB17A0D1" modified="2020-04-22" version="1">MEFPYFPNHQSQSFPIYNLHGVPALSQDGNNNFSDHNNNRQPNSHNEDPQESFGSLNYQSFDPTFRFQNPAAVTSFAQPPHSPPESYSKYSASSSDIFAQQTDPTSVDGDPGLGRSSSEEKESGVPAQSKRKAQNRAAQRAFRERKERHVRELEEKVNNLQQSSSTLMADNERLKRELAKFTTENEILRATSGSAGRNNNLSNEPMMTGPMRYSPTDFYSELVPESEPARLHRVSTCAKTGEKLLGAGATWDFIQGHELFKRGLVDLKYVSDRLKSLAQCDGQGPAFPEAEILKAIEESASAHHDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR03</accession>
    <name>A0A5N6TR03_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742146">
        <property type="protein sequence ID" value="KAE8148786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR03"/>
    <dbReference type="OrthoDB" id="4477787at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024945999" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="189" mass="21507" checksum="4C6870C74923BA3F" modified="2020-04-22" version="1">MRLFAGVFLFYITIATAINTSCFKVITALAGRPSDLYNKFQQHICDQGCRPTVPHWDLWTRNNTFLPAVRSIMARLDAPRQEAALLKLGDDAADIIKRRCGPMLHGGHLCADAEMLAGFGNCFKKNFVRAALMNLPTLLPMVSEDVCREQLAYLETDQLWEEIIPENMQAYARDCQGLRELEERRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRK0</accession>
    <name>A0A5N6TRK0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_130795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRK0"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="719" mass="79589" checksum="7864CB6C357289E4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS98</accession>
    <name>A0A5N6TS98_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_4827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS98"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22314" checksum="CDB2EDD2B7B59DE0" modified="2020-04-22" version="1">MEMRTLTHALRSRPTSILSKQSLTTQIIRPSIRQYASKSPETPAPAQTQTPAQGSKQAPSDFDEIFSKLNLNTAESSSRNRDAKDDPLALSRAVKMSAETDNYRNQSRRVNLKLGPSLGRQVHVEPEKGTDVSSALRQLHSACMQNRVKTQSLNQKFHVRRGQVKKNLRIARWRKLFKFSFQKTVGRIQKMRAQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSE6</accession>
    <name>A0A5N6TSE6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_5165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSE6"/>
    <dbReference type="OrthoDB" id="5431097at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="453" mass="50649" checksum="B01AC45A5D937543" modified="2020-04-22" version="1">MLSIMTVAAPPVAPVHENGLNGNAPGHHHVNMSLPRFHPIAMNPSQPVHPEQMIPNHSHFRPFPPPPMQEPGPPGPAPHPSHIDQIDARLRQLEHEEAARMAARSHLLAIRKREDEEFRRMTESAEAEEEELRRQRKRLKRESMGLGYNASMDSPPLRPTPPRRLSETNAATTLAFFKQQSPPEPRPIPPPPVQAPPPHPPPQHIPHDPTAGTIRRKQKYTIKNVEAWGERHGRPAAHDPSGRALWKRPSDGSLVYLTCPVSGCGKADFVTLHGFMCHLTKKHKDRSLGSQSRALEVCGIVYDPNAPLPPVATVQRASTEESRGDSAPTDPEGYAQEIEYSSGSEDEDMRKHPVKAEAADRTLPAPPVPYHHPDEPSKARKLNNSTKQSISSIIDRDPEDDPRERLASIPPRPIEPMARMSPDPNPPIREIDMLRHDERNHDHIEPKELAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSH5</accession>
    <name>A0A5N6TSH5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_167913</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742127">
        <property type="protein sequence ID" value="KAE8149318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
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</entry>
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                <person name="Nybo J.L."/>
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                <person name="Chovatia M."/>
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            <strain evidence="4 5">IBT 18842</strain>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1024"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="1001"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149380.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1532" mass="167294" checksum="D03A5EA649AD7426" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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        <name evidence="11" type="ORF">BDV25DRAFT_155915</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
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            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149806.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42306" checksum="5B8282C8CDBAA664" modified="2020-04-22" version="1">MVYLRHWLAGGALLLPLVVAVDPRLCQTGNEKLPESQFTLKEVEDSFLPELSEIFVQTNSNVSVADVLDSANRALVQKSPPLGNGHPVESWAWNSGDEATSKWYPQGVTSSGDALAAGKWDGREAWIVTWYQKTGGKNVRLSFVDRDTHQYRHVLLVEPSAPDDFKPVGIHAGGIMWYGSALYVVDTHGGLRVFDLNHIWKVADGDQVGKKSGGGYSAANYRYVIPQIRKYDWKALQPDSTFSFSWVSLDRSDSPDTLLVGEYTKDDTNTPIRLVKYALDYQTRKLRTTNGVATATFAHCVDILRMQGGYSLGNKFYLGRSNGESKGSDLFVWSPGSSATARSQWLMAGSEDFSFNPSRGEWYTITEHPGKRYIVAYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU46</accession>
    <name>A0A5N6TU46_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_120558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU46"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="542"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1039" mass="118210" checksum="590F3CE96E556CB2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUD5</accession>
    <name>A0A5N6TUD5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_140356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUD5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821253" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="182" mass="19439" checksum="FEA1F4D7126617CB" modified="2020-04-22" version="1">MRIFTLGASLAYLLCFGAPVAANYQTDYDRLCLKGNPVTVGSTTYTVSCDKTLGGSSPPVQKLGHTTDPSPEECAQVCENDRSACSAVIWATNACYISSDSGTSLYNAPGVVVLTPPPGKTPVEVLQEDLRTCENARDDYKKQLEDEINKHKPAPPPDPNAPLDLRFGGCLPANDEGLLGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUT7</accession>
    <name>A0A5N6TUT7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_129803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUT7"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="106"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="351" mass="39056" checksum="E20A808D33CFD9D9" modified="2020-04-22" version="1">MSLRQFLRPTAFSRPFTRTYASQTPGNPVLEIFNRKVKHLQKDRAAQNVEESRKTDYIKDEVAMRLCERLLDIKRDIPKVLDLGANSCNIARALTMPDIDPDMPNTPPLANRISQLTCVDTSHALLHRDADDPFNKEINLKREVVPDLETLPYEPNSFDAVLSSLSIHWINDLPSLLAQVNSILKPDCPFIAAMFGGDTLFELRTSLQLADLERRGGVSPHVSPLADVRDVGGLLNKAGFKMLTVDVEDIVVDYPDTFALMQDLQSMGENNAILHRELGPLSRDVLLANEAIYRQLHAEDGSRGIPATFRLIYMIGWKEGEGQAQPLARGSGEMNLKDLLGGGDFSGPKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV10</accession>
    <name>A0A5N6TV10_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_172522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV10"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="4">
        <location>
            <begin position="101"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38388" checksum="627882DCC6602063" modified="2020-04-22" version="1">MSKGRSLAIAALGATAGAGSAVLYTKQNQPVREVLQPVQDGIQPIPQSKSFESPGITIASRSLAKPSPGIAILQDSSGGPVTPDGILKYGHPGPVNDELNTISHFGAYDRRTRNPIWVAEHMTPESIAMGTAERKNNFKLDRSIPAAFRARVADYTNSGYDKGHQVPCDPSKWSQDACDSTFKMSNMCPQVGVGFNRHYWAYFEAFCQRLTTKYPSVRVITGPLYMPEKGDDGKYRVSYEVIGKNNVAVPTHFYKIIFAEEENDPDSIGSEVAVGAFVLPNGVIDKDTYLGDYEVDLAHVERAAGLEFAQNLKSSQRKRLCEEVKCDHNVKDFSDAVEDLTDEFDRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVC5</accession>
    <name>A0A5N6TVC5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVC5"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="238" mass="26750" checksum="2C13EA43F210967F" modified="2020-04-22" version="1">MNWTGGRLHRHSSAQHSKAQRIRKPKEKAQQEITLFQHLQPKHRSDPPHHNLTQDNNNNNNNNNNKQVQPLPTQNPPTNLATLKRKLLETPDWASISAARPAKITFTTAEELAQFGKRRKLTDADRARLNAPHTQSLRAPLFSRAEPATIENLEIRINGEKVAPALQHPRPVHQRSSQSMLLDRGNSICGEIPGISTVLGSEGLDLPTSELEGSGYYSRRSSLLSEPNIWIEQARAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVU4</accession>
    <name>A0A5N6TVU4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVU4"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024913586" evidence="2">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="32353" checksum="C65389150CE70D9E" modified="2020-04-22" version="1">MKFRNSWLMASVVSTAVARPLARAVDTTYFFTFGNSYTQTGFSATGEQPSASNPMGNPALGTGTTTGGANWVGYLTTAENASLVLSYNIAVGGASIDNSLVQGSTDVDLASQVDIFDETYSSKPGSAPWTSENAVFGFWIGINDIGNAFYNTEADTFTPKLIARLAELVQRIYSAGGRKFLFLNVPPTSRSPMFLDQGNATVEQHAAYLAVYNKNLDSMVNEFKENNTEATVVYYDTWSFMTKILDSPTEYGFPDATCINDDGTSCLWWNDYHPSAKYQKLQAEDMKEALEPLGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW14</accession>
    <name>A0A5N6TW14_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_108017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW14"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024970782" evidence="2">
        <location>
            <begin position="29"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="817" mass="90212" checksum="EF9B253AA29D8C03" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW70</accession>
    <name>A0A5N6TW70_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_172248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742097">
        <property type="protein sequence ID" value="KAE8150301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW70"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="64565" checksum="8D1A2807291E705E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWB7</accession>
    <name>A0A5N6TWB7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_154088</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWB7"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="900"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114946" checksum="2D36F71981638E9C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWI8</accession>
    <name>A0A5N6TWI8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bladder cancer-related protein BC10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_106103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8150753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="BCALP"/>
    </dbReference>
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        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="155" mass="17434" checksum="C554628289C343FA" modified="2020-04-22" version="1">MFCLRSWLPLLFIPTNASPLFIISFVTLTYILHRPCIYCSALLLILFISSCHWSDRCFFDLRGDWFSPRFTSESSPAMISPNETIAGYVLETVNTTAKVLTSAVVDEAQRRLALDGSSAPELGSDGWTGVGLEWLRSLLGRREWTLPCVDVKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWL5</accession>
    <name>A0A5N6TWL5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_106340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWL5"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="188"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="407" mass="46043" checksum="77602865EBEEEC6B" modified="2020-04-22" version="1">MTDIQTIREELAQATQATRIVMRCLNSGKDSQESSQRALTLLADILDLLYRVKDYISWGEEKWFVEPSRLAALAEILSWFDATTKSLELYFQPGGVGVIYFRKHLLEKTFLPRLEQYKALLLLATQPDTSERSSLDRTIRNSLRANREVESGPKVDLQFEEDALGITSGLSAENFIVLADLCNRRLKGTCQWIFDHSEYRRWLLGSFKTLYCVGPPGAGKTFVSSVVIDSLQRTFTTPDVATIFVFCQEGKEKEHTCVDILSNILAQLVYRKRGLSYATSSLYYSESLTKGKASPKAYQNAIRAEVNRFSKVFFIIDGLDLFSEKERILSRLQKLPENAQLLVTLREVTKVVNASCLSVLASPEDIHRYTLSRIQLDTSFTGLFQGEYGPQLQQNTIQAVAEKCHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX00</accession>
    <name>A0A5N6TX00_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_153847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX00"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="675" mass="75865" checksum="F1A60AD58E3D517F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXA7</accession>
    <name>A0A5N6TXA7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXA7"/>
    <dbReference type="OrthoDB" id="4510425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024884564" evidence="2">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="208" mass="22037" checksum="F05CA283A32FCEA2" modified="2020-04-22" version="1">MQALLCLFLAAGPVLSIPLSQNQNLPRQINSNTNAGSNWDVSIPNGPSYTSDTSASTHYTEDYLPGQKGFSAGSDVSDSTDVAIPGGPSYHSNDYVYSSYEEAEPEAELVPTSTSTLTSTSTLTSTSMLSSTTMWTSTFTTQTPTEKPVTETPAQPILPPSPSPTPIPSEEVTPPPAEEVEECPAEESEPEPETEPIPEPAYTCQCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXL6</accession>
    <name>A0A5N6TXL6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_139222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXL6"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="51813" checksum="3694B4DD3EFA2013" modified="2020-04-22" version="1">MQPVALQPTRRTRRCMPKVRSGCATCKIRHVKCDETRPSCQRCTRTGRQCPGYPEPKPSASSVQIYNLPFKVPGSRKHRELLHFYCSEAAQTLARFTDPTLWTRLILQRSQHQPVVRNALVTLSALYRDYLVSGPVRTPSHLQMMFNSHRQLRLHLLAADACPETALLCSLIFYLFECLSGNTAQALWHLDQGLSLLTWCRDTCSNLSDPDALFPHLRSIYAKLDIHATIYNDSRLPTLQLPAFPLDSATPGLVLPHTFATYHDANDALTVLQNQTMNHLVHHIELSSDSWTNMSPSLRNGVIHLDAMFARYIAATGPLLAKKDPDPRVQLLQIQATIFRAVLLENVAKALPHLSSDAQTLFTDAVDQVETLLGTCAGVGFTVSTNLVAGLYFICMKTRHATVLARALELLESKRMSRDGLWEVNDAVRVVRAMPFGGGKLEDAGRGIVDGKGGLEGAVMRLHIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY16</accession>
    <name>A0A5N6TY16_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_152838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY16"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000009">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000316">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="122"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="323"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="505" mass="56495" checksum="9453938E385A70DD" modified="2020-04-22" version="1">MSVFRWLSPFSPRFLSLSIKASLHHSFPCSNHSRPFLFYFKTTYNPSLPLSFSFFYSPLNIQESLTLPFSTLVIPSIDILHWTLSTSLVSLYLLLLSHTDSSAFLHLTQSIAGFQPSIMGKKAVQFGGGNIGRGFVAEFLHAADYEVVFVDVMDSIIDSLQKNPSYEVTEVSEEGENTKTITNYRAISSKHNESDVVQEIATADVVTCAVGPRILKFIAPVIAKGIDARTDSKPLAVIACENAIGATDTLHGFIKDNTDSERVTTLYDRARFANSAIDRIVPNQPPNSGLNVRIEKYYEWVVEKTPFGEHGHPDIPAIHWVDNLDPYIERKLYTVNTGHATTAYYAHKRGKKMIAEALEDPEIRSIVHKVLDETASLIVAKHGIPEQEQKEYVDKIVSRFSNPYLEDNVERVGRAPVRKLSRKERFIGPASQLAERGQKFDALLGAIEMALRFQNVNGDEESADLARILEKSADEATAELTELEQDHPLFSHVVERVSTVQQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYR7</accession>
    <name>A0A5N6TYR7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tim-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_138819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742070">
        <property type="protein sequence ID" value="KAE8151487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYR7"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024904294" evidence="2">
        <location>
            <begin position="21"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="121"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="466"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="748" mass="85052" checksum="C3DA204C46174EDF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYW7</accession>
    <name>A0A5N6TYW7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_152447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYW7"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47317" checksum="31342A67D53BFD60" modified="2020-04-22" version="1" fragment="single">MTSDERRCFSYFQHRTVPEIMGYFDSALWQKLVFQVSQAEESVYHAVVALSAIHADYETRGRPLAKEDLDNPWHRFAIDQCGRAFNQLSTRSASQDPNLREVTLVCCVLFVLAELMRGKYELAFTHLQNGLQILRDTGCQRSAYMAPGDTSTLEQSLVDAFAHLDVQSAFFGLGGLVLPLKPVLRLTHNKVHVFTSLFEARQVFDPLLGACFQFHTTTATKPREEILADYENLSSWQFDLSSQLRHFAEAFIPWYANVSDQRSDKERRGADIIYLHQLVLSMLLERGLLSRTEDVVDYYKPTFERILSMAESIIASFADRPSVLVDMGVIPPLFFVSTECPDPTVRWRAVRALHSWPHREGPWDSKLIAKIAMETIAAEHGLSLNNGQDGLEAKNQDKPFRVCSAFTTITEDQSEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ04</accession>
    <name>A0A5N6TZ04_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ04"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="50494" checksum="87BCEE7CE565651C" modified="2020-04-22" version="1">MGLFNRKQRLSLITFAVFYFSLFFFCRSNSARDPGSFFFQPREGYRPSYTLQRIHESLNFLSRFNQTAAPSELSAHRNDPSVQHADICIGIVTVKRPLQQKIETTVASIVDNLSQAQRSTLAIHVLFAQTTPSTHPSYTQPWVSNALDRALTYDHFNDTDISYLRRLERSKKFFAEKSLIDYRLSLQSCLDYTDAPYFLMLEDDVVAQRSWYLTTRQAIDRIETWQKRSLLSDWLYLRLFYTEKFLGWNAEHWREYFAWSLLVVVAVASLALSTRRVTRSTHDLLSNSFLLVLCFLCVPLLILLYFASGRVTVQQPMKPGIHFMNRHGCCSQALLFPRDQISRVMTYLQKMEDQSKPKPVDTTLERFANEFEIDRLAISPPQMQHIGAASYKEDEKKWRKGEYPVQGAHGVWSMQFETAYESVSADGVVVDTLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ28</accession>
    <name>A0A5N6TZ28_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ28"/>
    <dbReference type="OrthoDB" id="3922101at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44628" checksum="BB57820E717BD2D9" modified="2020-04-22" version="1" fragment="single">MNTTPTKCYDMETWDLQLSVPDIHIILESTRESYAAPVIGSLSISAPSSNLRPTSDIYPNINISLTRYILPNRDNSATLSSNKCPNFFARHIKRQKSTSTRSYPHATQCFESRAETLVECDLRHAPDEIRPQEAENRTWLKYNFSVPVPGNLPPTAETRLGDIMYAIEATVPSSAIVAKPMTALRRVKMVRRAVAEPVHYFRRYPGENVITELRLSPKGEALDVEKSQAAYSAQWMARSTITQGARKTEVKYVVAKEIAWRVEETVKYLSVSRRGPRADTAQINCKSQVVRQLCDGRQKGRWIASGGIDEGIDWFEVPFDITIPRETKTTGGISSSSYMCQHQPSNCSCNSGQTPAITVDHQLVLEVITGEDTFDRKTGNLVDRRHRVKSFEAVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZH2</accession>
    <name>A0A5N6TZH2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Extracellular metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZH2"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6330" checksum="9AFE9B694A57B236" modified="2020-04-22" version="1">MPATDSLQPPLTPAEREIVKSYGGWTNFLFSYGLKPWNDDDAEEGLMILKGLANDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZU5</accession>
    <name>A0A5N6TZU5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_85334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZU5"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001607">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="231" mass="25496" checksum="F9D20F4403850575" modified="2020-04-22" version="1">MLSAGERLQSALNKNAVVDATRKPVGKSSLSHSSTSMWSVNPKPEQIQHIWVVTGPAGCGKSTVGRGLQAALDVPFLEGDDFHSAKNREKMGSGIPLTDADRWDWLICLRNAAITALSPSEANNYHPPSGVVVACSALKQKYRDVMRVAAYGTPSVQIHFAYLKLDETVLLQRVTARQAHYMKSTMVQSQLQDLEEPQGEWDALTINAHAPQEQVMREVLETVRDKLAEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U087</accession>
    <name>A0A5N6U087_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MACPF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_138301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
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        </source>
    </evidence>
    <sequence length="305" mass="33742" checksum="25AF510A25D5345B" modified="2020-04-22" version="1">MSRPRSLLLTLDAFGTIFYPHPPVPEQYASAAHNFGLPQTVITPERVQSAFKTVFKAQALARPNYGRADVIAGRYGGPRQWWDEVIRGSFTHILSESDPANNAEGNIPDGLIRHLHQRFASSQGYASFEDIEPFFSWLRRVKGTGVGPFDRVVVGIVSNSDDRVPAVLKSLGLRVGDCRADEGVSSMRLPGYEERTVPGSESGEVNDVDLVVTSYEAGYEKPSPRIFEVTKRQAETLVRNDASVGDAGDWTCVHIGDDLKKDFWAAREAGWEGYFLPRGQVDQDLEGVKTIESLLDLIPVLEGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U125</accession>
    <name>A0A5N6U125_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U125"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="290" mass="32879" checksum="2E8BC6D8B65CE457" modified="2020-04-22" version="1">MTKRLNGRKGLDQNQNQNRNQSQNQSQSHNQSESQRQTQTTENATCEFTYPCTAASAGSAKRKVISHIFGRNKRSTRSFPGEVWVHYCRQHYQRARYRVEWPFTQCDMLLVVLGRMEGWGGVREWEVVLRKREVERLRALYGGVLQGRRRRVVGGGGEGCEDDLDESGSGSSSGSVGMGRGEEGEEEERHQRRKPTVVTSPVPEWLLQEVGAGKSFAELRALVRRLKLHMAGLRENGASEQIVFPDIEFMPTFQAWVQPSVRPRQAPKQKVLRKKGKGSRVSRKGAVKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U169</accession>
    <name>A0A5N6U169_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_128024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U169"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53946" checksum="C6D01EE087504E05" modified="2020-04-22" version="1">MPSIETIVIVEYIKCEAEYPQCDYCMHHSIVCTYNRIASGSRKRKEHYEHVYDEGFWNKRRSIQPKLSFTKTSMFSLGFMYPNGMRHTAHEGLAWIELRTGETVNAKVPPTRPSLKMPNLPASPIVERYVTLHCSSYQSLVFPVIGKSLYTETLDLAYGPPGHGAESAKSCIYAFLSVATTYAMAAESSTVSIINEMTIDGLQALIMLVWCYFRLNKSIPDCHLRDLFWLCYSFDQDICLRIGQPPCIPGVFCNLELSPDYALLQDTNLQQEQTLSITNDTLPLYPWDLRLSQLKADIYVTLYSTTACQKSNSETYGDIRTLDQALEQWRTSLHPTIRPTLQFLPWMPVGESLNTQAVMLRLAYYHCVMVIHQASERRHEGPGLCSSINLVVSASRSTLSFLQIASPVVEGECFCINVTSSGVVIFYAITAILTLFRNILKNPLDSATTDFLEVLENAPNLTHENPTRTLTVGLMVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1K7</accession>
    <name>A0A5N6U1K7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_170773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1K7"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="288" mass="31787" checksum="B8C69D4B05E57DA1" modified="2020-04-22" version="1">MRKSIDLDSPDRPFDNIINFRDVGRSINSLMGRQVLKEGILFRSARLDDASERDKKRLTDELHIGSIIDLRSSTEHDMATSKRGDGQPSNGYSHLPRLEGVRTHLISLTGKAFERSLLWRLDWWNFLKVLSLAASGNRPAAVCLVGEQVMTPRGLTGLAKDTLDSSTVEMRDIFERVSADGPVLVHCTQGKDRTGLVILMLLLLAGVVSEEALVADYVRSEGELVVEVEERMKEIRKLGLGVEYTRCPGEFVGEISEYLGGFGGVEGYLGSVGVSSDVVDRIRGKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U207</accession>
    <name>A0A5N6U207_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_127847</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U207"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="21">
        <location>
            <begin position="46"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8152635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="822" mass="91987" checksum="89FF5D5E1BC2F4FF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U266</accession>
    <name>A0A5N6U266_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_150683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U266"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815276" description="Glutaminase A" evidence="1">
        <location>
            <begin position="20"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="117"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="351"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="529"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="669"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="91858" checksum="C7E7722F7D43C07A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U269</accession>
    <name>A0A5N6U269_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_137584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U269"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="36102" checksum="866CED59FFE4E234" modified="2020-04-22" version="1">MACPTNIDLDSIIDKLLEVRGSRPGQHVKLPESDIQYLCHKAREVFMSQPIFLELEAPIKICGDVHGQYYDLLSLFKYGGYPPESNYLFLGDYVDRGKQSVECICLLLAYKIKYPEGFFILRGNHECASVNRIYGFYDECKRRYNIKLWKTFMDCFNCLPVAAILEDKILCMHGGLSPDLNSLEQIRRIMRPTDIPDSGLLCDLLWADPEKDLTGWGENDRGVSFTFGPDVVHRFVQKHDIDLICRAHQCVEDGYEFFASRKLVTLFSAPNYCGEFDNAGAMMSVDENLLCSFQILKPAQKQKISLRARAKGKLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U288</accession>
    <name>A0A5N6U288_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative VanZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_150664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U288"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024987196" evidence="3">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="223" mass="24446" checksum="372162C3FF471D0E" modified="2020-04-22" version="1">MRIRYPFAGAFIFLLILAAYVGLLPHSAQSSVPAQLQPNDKFLHVITFFFLSLVFYWIPDTTRRRTLQLTLIVCTAVLGIGSEIVQGLLPNGRSFDPFDLLANIVGSLGAVGLCSWYHRRMLERRRKARFGALGDGATDDVELGPGPRHTDEADDDGLGPQETGVTNLEREVDSWDENAVDNWDSDDDANESGALTGASHDASRSSSTPAAHADWDEGKKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U298</accession>
    <name>A0A5N6U298_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_170000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U298"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="327" mass="35411" checksum="0726C07DB7E69E41" modified="2020-04-22" version="1">MALPEHPHIVFGTASFGTGTAQAKICDEETARPVLATLQAKQITNLDTARAYPVGSPGTSEKLLGQLQVASWATVSTKVQSWAPGSHQADRIRESIDLSLATLKTDKVDIMYLHSPDRTTPFEETCRAMDAEYRKGKFARFGLSNYKKEEVEEILTICETHGLVKPTVYQGRYNAIIRSAETELFPLLRQHGMSFYAYSPAAAGLFTGKVSQESTQLAGSRWDNTTNMGKNYQNAYFKPSVLAAAQDTAKAAEAAGISGHALALRWTIYHSALSHEHGDAVLVGASSLAQLESNLDAVEAGPLSEDLVKLVINVGDLVADEAAPYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2A3</accession>
    <name>A0A5N6U2A3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_150569</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2A3"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000049">
        <property type="entry name" value="RNA Polymerase II CTD phosphatase Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="155"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="507"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="814" mass="91200" checksum="E70514D5767E1533" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2K8</accession>
    <name>A0A5N6U2K8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_150442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="31441" checksum="5F26668A8B36DF5B" modified="2020-04-22" version="1">MASYDVCTQVSELCPVEATTYGYYPNYGGNIFFAVFFGLCGVFQLGFGIYFRSWTLMVALAVGTLLEMAGYIGRVLMNKNPWDNGAFKLQIVCIILGPTFIAAGIYLTLKHVILSLGPEYSRLKPKLFTWIFIGCDIGSLILQAAGGGVAAAAGSDQLDLVNAGNNIIITGIAFQVATMSVCGLLALEYFVRYIRQRGSVEKSLGNGDGWRIKLVIFADVFAYFTVLIRCIYRIPEMAGGWGNPLMQREDEFLVLDGMMVALACLSLTALHPGFSLPSLRKGRKNGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2L1</accession>
    <name>A0A5N6U2L1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_127750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2L1"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="730" mass="83018" checksum="350F92884E870F4E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2X6</accession>
    <name>A0A5N6U2X6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2X6"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40157" checksum="9D01094B2A15CDFB" modified="2020-04-22" version="1">MSNRIRLGIVGLSADPSHCTNYIHKLPLTTTPLKEKYEIAAVSMSSAEKAEAAALAHDLPKERAYHTVESLAKDSDVDLVVVSVKVPRRAELAMAAIEAGKDVYVEWPFASNLAEAEALAQRAREQQVKSMVGLPTRLAPQVLKMKEIVQSGALGRILATNLLVTDDLFLKFHADKRHSHDRKNGANIVTIAGGHLLDAMAFLLGEFTTLHAHTSMLFPKPVLCDTTGKLKTGQFNDSPDTFTLHGRIGNSEVPVSVCMYSHPPTTPNLFQWVITGEKASLKMEGPSLIIHAIPPKLLMTSSGSETVSWEEINLANTVVPGAEYQAWLDDDRDRIVTLDEAVVRYRMVDAIFRSADSGESTSYRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3E1</accession>
    <name>A0A5N6U3E1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_45091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3E1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20013" checksum="5EFE58B5967F2935" modified="2020-04-22" version="1">MTSTSHTSDLRQPTAHITAHDASGKAIVRSSDDFAWQRFDDDKMAFSVLYTTSKFPANLNNEADIQSHQATMSGGLGLVNPNGTVFRCVDFAPGYHAIMHRTKSLDYGILIEGQIEMVLDSGDIRLMKRGDVAVQRGTMHQWRNPSQTEWARMMFVLQDSNTEDVGGEDLGPGLEGLPPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3N0</accession>
    <name>A0A5N6U3N0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3N0"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="199" mass="22467" checksum="C97985436CE9C7D1" modified="2020-04-22" version="1">MTPRVFLLGGQGKVAQALTSLLLQRFWTIATVIRSKTQQSGILRLGQHQESSNRLYKTWRKSQAMQMHRAGGKGGPERAIAIDRNSAKQFIFASVATSYVLKLLMISWLGCRRRRPSWWAEKEWDDMQTVNGTELGIRLRSTMPFQAISLRPGWISDDKAPEEIAIGHTRTTGTVTREDTARVAMKLLVRPDTHAGLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5K4</accession>
    <name>A0A5N6U5K4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5K4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="66" mass="7770" checksum="E0FEBCD3F94665B9" modified="2020-04-22" version="1">MYSRLLTLVLTRWLTGTRKASVCKYSVGKAEKTRSRNQGILVYTISLFLSFFFIFFFSNQSQWQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5S4</accession>
    <name>A0A5N6U5S4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5S4"/>
    <dbReference type="OrthoDB" id="5411560at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113063" checksum="70733AE2A648BEB8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6D7</accession>
    <name>A0A5N6U6D7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_126677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6D7"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="122"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="471" mass="53406" checksum="6B727B7078D16EC7" modified="2020-04-22" version="1">MPERDEQAKICRAWGYTFEWNSLHQTSEQLHSMMLTYDKLVDDCLERLDEISPPNSVRSNDTEAFKTDGPKPKRDLYSLLRSHAKDDPKLQALWSEINTVPEWVNWDQIKRGQEVFFRYGHPILNVLSFQSLLGGMGAPRVVETLARTGGFSAHVVRRRLLETLQHILQVSYSLDSMKPGGEGHVSSVRVRLLHGSVRSRLLKLAKTKPEYYDVKKYGIPINDLDCIATINTFSTSVVWVGLPRLGIFLRDQEIDDYIALWRLVAFYMGTPTEPFKTTARARAMMESLSLSELDPTDTGKILAHNIIIGLENTAPTYASKEYMEAMARQLNGDELSDRLALPRPALYYQALVYGHCFVVMVSCYGLRALPQLDQRFIAFRRKLYYAIIMDKERGLGGESVFEFKYVPFYNRTTKLGERKATKPTQGGIETVAQAGLVAALAIIMGLLCGTVFGFKMLVPLVFPEIVAQRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7B2</accession>
    <name>A0A5N6U7B2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fatty acid repression mutant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_135874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7B2"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="202" mass="23225" checksum="3C0006299A198166" modified="2020-04-22" version="1">MSKSISDGFKDRRTIYALTNESTISDDRLEQLVRDVVLHTPSAFNSQTSRLVVLLKKDHERLWDIAYEVASTTVPSEVFEKVYKPRIAMFRKAYGSALFYEDAAPIRPLEDKWPMLKDKFPQWSEHASAMHQYALWTLLEAEGLGCSLQHYNPMLDARIAEEWKVPADWSLKAQLVFGKPVGGPGREKAFEPVEQRQFVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Q3</accession>
    <name>A0A5N6U7Q3_ASPAV</name>
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        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_135801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="459"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
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            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="534" mass="58640" checksum="875BB83306382A84" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U845</accession>
    <name>A0A5N6U845_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="678"/>
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    </feature>
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        <location>
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            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="298"/>
        </location>
    </feature>
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        <source>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="709" mass="81159" checksum="FCD549350C99415B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD91</accession>
    <name>A0A5N6TD91_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_98125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5341904at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="240"/>
        </location>
    </feature>
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        <location>
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            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="758" mass="82628" checksum="3D79F35AC72FBB19" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDE2</accession>
    <name>A0A5N6TDE2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_96002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742536">
        <property type="protein sequence ID" value="KAE8144405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDE2"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="100" mass="11186" checksum="27371CB2B5F3EA77" modified="2020-04-22" version="1">MLRQSIRPLTTANRALVSRSFSALAPKMAEGDTGAPRAGGAQSGDAFVRREAAQESLYIHEKEREKLLALRKKVQEQRQHLDELDKHLEEMSKSQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE48</accession>
    <name>A0A5N6TE48_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 71-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742467">
        <property type="protein sequence ID" value="KAE8144645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE48"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024853862" evidence="1">
        <location>
            <begin position="17"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115654" checksum="3FDAAE58FE9FD10E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEK8</accession>
    <name>A0A5N6TEK8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742490">
        <property type="protein sequence ID" value="KAE8144541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEK8"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="431"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="526"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="618"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="107123" checksum="558B221F2BF1E8D0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEZ4</accession>
    <name>A0A5N6TEZ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED18</name>
        <name evidence="13" type="ORF">BDV25DRAFT_165846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742417">
        <property type="protein sequence ID" value="KAE8144902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEZ4"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.320.10:FF:000007">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="269" mass="30216" checksum="091C032304527DD7" modified="2020-04-22" version="1">MHELLLFASVPAHQHHELLQQLAGLTAMQPRHRLERRVIYKAYRKPGLINTRVGASQDLQGHDMQRLNKMLNGGMFYTQVVGPVSEADFGAQSPSEDPDAPMSGTDAEEGSGNHLYNYENQPWKLEFRDIPEAGTRSAVTSRLMASASLPKGDISTPMNAWGYSYVTEYAVEGDAFILNDIVIFLHRVLHYPTEQESHAPRRQLPPFQQMSPLERTGSYVLQASITVQDGGNQEMMRTASQHLFGLREQLKSAVRLEQADRLSLDTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF09</accession>
    <name>A0A5N6TF09_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_165683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742409">
        <property type="protein sequence ID" value="KAE8144955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF09"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000722">
        <property type="entry name" value="Nuclear mRNA splicing factor-associated protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="393" mass="44679" checksum="6FA0C3BC17BF7B70" modified="2020-04-22" version="1">MASHSPEAPQPLSNFPQDPTEFDSDPRISFSKLDDKFILETEDGQEFEFDTVLKRWIPTVDEELLRKQQEAYKVQGVDDSELVTASQLRKKRKQQGTKDDEGNGQKSKKPRVNTALYVTSIPLDADFEEIRYVFSKCGVIAEEIDSGRPRIKMYTDDDGKFKGEALVVFFRPESVNLAIQMLDDSDFRLGVTGPQGPMRVQPADFSYKSQQEAPIKTSARDKRKIMQRTQRLNSKLADWDDDDPSALPETNSRFEKVVILKHMFTLQELDEDPAAILDIKEDIRDECSKLGEVTNVVLYDKEADGVVSVRFQEPEAAKNCVKVMDGRYFGGTRVDAYIADGSERFKKTNEKRAALEDLAEKGFDADEDEEEAQRLDEFGTWLESSHTVENTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF83</accession>
    <name>A0A5N6TF83_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_134356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
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    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
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        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
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    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
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        </location>
    </feature>
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            <end position="411"/>
        </location>
    </feature>
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            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="46421" checksum="6D468E662409844D" modified="2020-04-22" version="1">MAFGKLYGQPENGRTIAALVAAKANDVELELVNTEANSAADFNKSAEYTKLNPLGKIPAFEGANGYTLSEVVAIAVYVTSQNEKTTLLGKTKQDYASILRWLSFSNSELVPRFGAWYRPLLGLDGYNKKSVDEAAKACLKNISVLEKHLTANTYLVGERITLADLFSAALLTRAFATVLDKKFRDEHPAVTRWYKTIVNQPAFKAVVENPVFVEEVIKYTPPKKEEKPKKEAAPAPAAEEKPAEPEQKKPKHPLEALGKPTLVLDDLKRTYSNEDTRPVALPWFWQNFKADEFSLWKVDYKYDNELKLTFMANNLIGGFHARLEASRRYLFGAQSVYGANYDCVIRGVFLVRGQEFKPAFDVAPDWESYNFEKLDPSKEEDRKYVDDMWAWDVPVVANGKELPWVDGHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFT6</accession>
    <name>A0A5N6TFT6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742376">
        <property type="protein sequence ID" value="KAE8145176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFT6"/>
    <dbReference type="OrthoDB" id="4157208at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="94" mass="10350" checksum="A5C014A1684D89B6" modified="2020-04-22" version="1">MDKTQQLTTSPSLSFSPQPQPLKHHQQQQQQQQMNQMNQIPETQNTSQPSQGQISGSGGPTATAPFLRDFSLVAEAAKRAQMSVVMRDLEAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGB1</accession>
    <name>A0A5N6TGB1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_164804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742352">
        <property type="protein sequence ID" value="KAE8145373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2506204at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024950694" evidence="2">
        <location>
            <begin position="24"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
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        <location>
            <begin position="735"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="775" mass="86008" checksum="6F9F3E038B2A9CCC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGD7</accession>
    <name>A0A5N6TGD7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742345">
        <property type="protein sequence ID" value="KAE8145448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGD7"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="250" mass="28688" checksum="0A47285ACAC6F526" modified="2020-04-22" version="1">MAPITIPQFLLPRGAPSTRALQSLTRTGINTTSRRCASNNSKPRVLEQPDKFRPPSHPARRVLPTRNGKVLARDPVHYGPKLTEKEREAMKNKEYPNMFPPEGTVMYKFLTNRWIHIWIAMGVLTSLATFTFTTNFRQTSPFAHLLPPWSALFSHPIDTISQALSVFRMHVQHTSLETREKRHRRVEDADKRRQYRIAHGLEEPEEPKGAEAEVVDDQSPVADESASKVSSEYVDWEGKKKPVKKWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THA3</accession>
    <name>A0A5N6THA3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_63512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742321">
        <property type="protein sequence ID" value="KAE8145687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1382"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1431"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1452"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8145687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1468" mass="157755" checksum="47F8234B00AAC06D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THF0</accession>
    <name>A0A5N6THF0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742322">
        <property type="protein sequence ID" value="KAE8145680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THF0"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="47328" checksum="66366CD2661257B5" modified="2020-04-22" version="1">MPETLLSYLTRPNPRIARRAQGPVKFTFNNLWLPVENLEPWTEFNYETLMSLFGPDLSRQVDLDDPTPQCEASMFSQIYDEQTLGHVVASSIMIPVSCALPQELFAASGGITWETDDCFPDWSAGNQYRMQEYQDPEGTTVTKDRPKAIVLGDTKYQWSHEEAIRNVCSRHHGYEHTRPNNVLPLEQVQFYCAMYRCRFGFLVTDEGLLVLEAFQETDIQRSPRPRRNVRPPSHQRVISSSTVDMSISGLSEAVSDLSVRSADVGPPSIRLMKYAFVPWRAQGTGALTVKLALYCIVRIANEDSGLRPHYTPLTTMVQLSGGASATPIGGSPEPSTTVGKDKAPAVGSIEPVTSTSNPRTSNESQYHNVRVFWNNDHTAYNYQIDDGKWIFNDSPEKWQTLENNIYNYHMKPPLRGNKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THI1</accession>
    <name>A0A5N6THI1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome oxidase complex assembly protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742330">
        <property type="protein sequence ID" value="KAE8145599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THI1"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="183" mass="21059" checksum="11C0D02E479807C1" modified="2020-04-22" version="1">MSLQTVGRRIGAARPSYRGLYIPRRSLIPAPRANSGPLMERRADRDLPTINTERRWMRTLPFFAIAVGAAMLGIFNYQKSSSSVVSSTLYALRTSPRAREILGDEIYFAQKIPWISGEMNQLHGRIDISFWVKGTTSHGKMRFRSIRPDRMSYFRTEEWSLEKEDGTVIQLLENDSDPFRQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THQ8</accession>
    <name>A0A5N6THQ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_163885</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742313">
        <property type="protein sequence ID" value="KAE8145790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000006">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000676">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024962017" description="Vacuolar protein sorting/targeting protein 10" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1357"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1403"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="49"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="707"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8145790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1486" mass="166225" checksum="B3C14CF6D8D4C99F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THR9</accession>
    <name>A0A5N6THR9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_133615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742326">
        <property type="protein sequence ID" value="KAE8145641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THR9"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="341"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="61664" checksum="4B603CB901C5DC41" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI12</accession>
    <name>A0A5N6TI12_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="4 15">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_170091</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="4 15"/>
    <dbReference type="EMBL" id="ML742296">
        <property type="protein sequence ID" value="KAE8145983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI12"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000036">
        <property type="entry name" value="NADPH:adrenodoxin oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 15 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="49"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8145983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="536" mass="59375" checksum="0C74470AD33E6B66" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIE6</accession>
    <name>A0A5N6TIE6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_55851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742286">
        <property type="protein sequence ID" value="KAE8146102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A5N6TIE6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="143" mass="15904" checksum="EF99FA23903824DB" modified="2020-04-22" version="1">MASVPSVQCFGKKKTATAVAHCKQGKGLIKVNGHPLSLVQPEILRFKVYEPILIVGADKFAGVDIRVRVSGGGHTSQVYAIRQAIAKSLVAYYQKYVDEHSKNQLKQALAQYDRTLLVADNRRTEPKKFGGRGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ09</accession>
    <name>A0A5N6TJ09_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742270">
        <property type="protein sequence ID" value="KAE8146335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ09"/>
    <dbReference type="OrthoDB" id="5356476at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="430" mass="46555" checksum="4BD4F9118248A757" modified="2020-04-22" version="1">MAIDPEPQPFPTAAQIPLQNFNLPQFPREAANLKHLTLTSDIKPTEYADFLATPLSQDAINPSIPEGIDSLTLELFSLGYPAPFLTRLGKALPRLKALTLYSHLIDGVSDDSRRDAGEFIHKALVGAKGDAGNSNGSGLRELHLLDAFCRKGFVSGIGDILDDLDSPEQGTQSALRFLEVSYTYRGHSDSDFLSRIPAEELPALLVSSLIAASFRLSPPASGSDTGLSDVPDDPADVDENGERVSGKKPEGIIPFSSAHSGALLLVDRLIGRASKEVKDVNDPENEPTPSEPPKLRMLDCTLYTLSLDQLEQILNYQKELAILNASVLLSTGGENTKRALLNTLQSSGKNMEVVEIVGVPEKEDQQFAESLDRATYFNSVLPSAADMRDLSAILPHLESLSMNILRAPGLGSVSWVRKDGEWVDEEARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ13</accession>
    <name>A0A5N6TJ13_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_169920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742268">
        <property type="protein sequence ID" value="KAE8146358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ13"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="486" mass="53131" checksum="162833D916606BF4" modified="2020-04-22" version="1">MGPLSGAICRETGEEGGHPFLVDFDGSDDPDLPLNWSFPRKIWVTSVVAVLNLIGTVASSIFGTGSQVFIQEFDISHEVAVLGTTLFLVGYIFGFIVFGPLSERFGRKWPMLLGITISSLFDIMPALGQNPATILIGRFFGGLFGVAPVAVFGGVISDCWSTAHRGIAMALAVSLVFSGPTFGPIFGGFIMGSSSLDWRWNMWVIIIVGLSACALCVFLYPETYPAAILRAKARTLRRKTGNPDIKTVYDKGTLSLNEVMRVYLVRPFWLITTQPILTLLTLYQSFIYGVLFLFYQAYPISFGTDRGWSMTLRYLPLVSIICGVFAGAIGIIVHNQLYFRHHCHGPDGSLIPEARLPPMIVGGVMVPVGMFWFAGTASPNIPWPSPVCASFLIGCGMYLLFIQGFNYIVDNYTSMANSAMGVNGSMRSVFGAVFPLFANQMITALGVARTTYILGAFSVALIPVPVCFWYWGHRIRAWSSTKTAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ27</accession>
    <name>A0A5N6TJ27_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742268">
        <property type="protein sequence ID" value="KAE8146356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ27"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="99"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="54849" checksum="EE37FEB696CD8E75" modified="2020-04-22" version="1">MESEMVEVKAVDSSDFLGVSYLFTTKENLSEHTIFKTPWISNLAYNSCQCNMEPQTTPNIETFSKRGQTAVKAGSKFITWDVINDMWHPQDNASGTLSVGLAENTLLHDTLLEYINSNVQLSAEHLTYNNGSMGSKALRKAVSHFLNRHFNPFRLVEPSHVLMTNGCSSAIEHLSWTLVNPGEGVLLGTPYYSTFIPDISLRPEAVVIPVKMGSVHPLSPGAVDEYEKAATEFEERTGKRVRAVVLCNPHNPLGRCYPRETVDRLMRLCQSRQMHLISDEIYALSVWENRVDKGVPFTPFESLLSRDCTGLIDPSLVHVLWGMSKDFGANGLRVGAIISQSNPELHTAQKCLSLYSFVSGMSDQITATILQDDAFTDRYIEMNREQLSQSHQFLIEALEKHNIEHSRGCDAGFFVWVNLGEKYLKAHPGEHDHGAALTDIIFQKLLDNKILVAHGTAYGSEKIGWFRLVFAHPIPWLAEAMERILRAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJW9</accession>
    <name>A0A5N6TJW9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_169690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742250">
        <property type="protein sequence ID" value="KAE8146632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJW9"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="226"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="423"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="768"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8146632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="98604" checksum="2BA2C676403DC5F0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK34</accession>
    <name>A0A5N6TK34_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl transferase component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742261">
        <property type="protein sequence ID" value="KAE8146451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK34"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="719" mass="81747" checksum="DF0668A984F7691D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKW0</accession>
    <name>A0A5N6TKW0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_161914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Magnuson J.K."/>
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                <person name="Machida M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Chovatia M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
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            <name>Zn(2+)</name>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="144"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="166"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="537"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="620" mass="68738" checksum="7A8A7CC0C03E36BD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLH6</accession>
    <name>A0A5N6TLH6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_160894</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="ML742220">
        <property type="protein sequence ID" value="KAE8147203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLH6"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8147203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26283" checksum="EA93EFD74F9153D2" modified="2020-04-22" version="1">MSRRSSAMPSNTSANSGVPHAGDGGQEKQKMLLSAETGHFSMVRALHLADLVTELNGFCGVMSVLSSMRYCLGDPNDYSAIWSALGFMPFGLFFDFMDGKIARWRKKSSLMGQELDSLADLISFGMAPAAAAFALGVRTTADHILLAFFVLCGLTRLARFNVTVAVLPKDKTGKSQYFEGTPIPTTLSIASLMAYWVSQGWVQEDLPLGLAAQGTPFEFHPVALLFVLHGCLMVSKSIHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLL1</accession>
    <name>A0A5N6TLL1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_143024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742222">
        <property type="protein sequence ID" value="KAE8147170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5352492at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="2">
        <location>
            <begin position="1529"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2305" mass="252948" checksum="572A4EC1129C0233" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLV9</accession>
    <name>A0A5N6TLV9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Golgi reassembly stacking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_160618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLV9"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000262">
        <property type="entry name" value="Golgi reassembly stacking protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="37489" checksum="19777A91D53C1326" modified="2020-04-22" version="1">MFGALNRFIGRLDSEPVQQPRTTSNDNAFGFQVLRNKEPELPLEPWFDFIVGINGRLIDDPDPNLFATEVRNCAGSSVTFEVWSAKGQKTHSVSIPISPTNPTLGLALQLAPLSSTQHIWHVLNIPSPLSPAYRAGLLPHSDYIIGTPSGTLRGESALGELVEDHLDRTLVLWVYNSEFDVVREVELVPTRGWGGEGALGAELGYGALHRLPVGLGEEVEGPGEVVFETRDDGSFTPVLNPPPTQAQPVAPGPAPGHYMVPANMTSPPPLASQAPRSLSGSPAPGQTPAARRSGKVRHHAVAPAFDEYFAEGEQKSKEQDYAPSRKGTPLPPPPKAGVLSPPSSGSPAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM48</accession>
    <name>A0A5N6TM48_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_33399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742208">
        <property type="protein sequence ID" value="KAE8147415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM48"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000077">
        <property type="entry name" value="Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="330" mass="38338" checksum="CDAE92721BF89A30" modified="2020-04-22" version="1">MAPSGQTIYQKDERALCFHHEILYEAKILDVRHVDPDDRKSPYEYLVHYKGWKNTWDDWVPQDRLRKFTEENRELATTLRREAEAAFRQKTTKSSAKKRGGSDRSSARGSEERQMSVPGRGTKRARDNEIEKEDNFYVRPSVRIFIPDNLKSLLVDDWENVTKNQQVVALPAKCSVNQILKDYVEAEKPKRASSADLDVLEEVIMGVKEYFDKALDKILLYRFEREQYRVLRKKWESGSGEFADKGPLDIYGAEHLTRLFATMPELIAQTNMDLQSTNRLREELSKFTIWLSKNSSQYFATRYMTASNEYIEKSRGVSNPTPGTATSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMH2</accession>
    <name>A0A5N6TMH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_30556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742201">
        <property type="protein sequence ID" value="KAE8147563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMH2"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="470" mass="50656" checksum="C4D6C908D231340E" modified="2020-04-22" version="1">MSQTTKWGQNNMGSAKPLIDLKRAVESITDIPDTILWAEISRRGRINDRDDGRTSCGSTDRGAYNTPIHVMALFLILVLSTLACSFPVLARRFPRLPIPRRFLFLSRHFGTGVLIATAFVHLLPTAFVSLTDPCLPRFWSESYRAMAGFVAMISVFLVVLVEMFFAMKGASHVHGSGYDNLISDVGGGDSASDCQNEGTEFLGFDQQDPAVNIHLEGIQDQSSACGLSQASGSLSGGSHDDSDPIGVNDTVTRKSDVDVDFEEDSAYGVARTEEHRTPFLHSDRQRSHNKGLGIREDGNFPMQNPQRQLLQCLLLEAGILFHSIFIGMALSVATGTSFVVLLVAICFHQTFEGFALGSRIASLIPDLFAPSSAKPWLMSLAYGTTTPIGQAIGLIMHNLYDPASTAGLLMVGITNAISSGLLLFAGLVELLAEDFLSESSYATLQGRRRIEACIAVAAGALLMALVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMK3</accession>
    <name>A0A5N6TMK3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UbiA prenyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_169200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMK3"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="328" mass="36816" checksum="33E733A2D076B5EA" modified="2020-04-22" version="1">MVQGDCYKTEPSAEMPHTPKNRSIFYHLYSLYLFSRNDFKIILLPQTAVGVFQALAGNVVTTNNTPHPAMILARVPLVAFWNWINLLIFNLANQRLPSSIVEDSIIKPWRPVVSGRVSEHEARWLLLLLLPLTICLSYCLNTSYEAMAMIAMVWMYNDLGGADENHGFRNLLNAFAFACYGSGSTIIAAGYGQHGLNQAGYIWLSMIGLIVFTTLQVQDIPDIEGDSARGRRTFPIVHGHWAARWSVALGTLLWSAICPTFWCLDVTGYLLLLVPGALIAYRTLSIHGAAEDDTTYKMWCGWLVLVYLLPLYKNPVALTQDFPIQNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMP3</accession>
    <name>A0A5N6TMP3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fork head domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_34663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742211">
        <property type="protein sequence ID" value="KAE8147371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMP3"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147371.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="713" mass="78063" checksum="314205019307C0C2" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
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                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">IBT 18842</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus avenaceus</name>
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    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="404" mass="45394" checksum="A287704B71DCAAC5" modified="2020-04-22" version="1">MASAPTNEMTPAEAESVYFNNYSPPKALPKHEALARAFINYHVEANRRLVLVTSGGTTVPLENQTVRFIDNFSAGTRGATSAEYFLQEGYAVIFLHRQFSLLPYSRHYSHSTNCFLDFMDEAPPPDSADSDHGRIVVRSEYQDQMRDVLRKYRYAKQNNRLLLLPFTTISEYLFELRSLATLMRPLGANALFYLAAAVSDFFIPRDRMAEHKIQSSELPQHLNKEEAIDPSDIYTGGIPQEAKPPTHSKKLVIDLDPVPKFLHRLVDGWAPDGSMVVSFKLETDPNLLVYKARTALQRYAHHLVIGNLLSTRKWEVVFVTPEAPYERWIRVPKSKRSKSISGAEDQVGLAEAKTAGAVARNNGETSGGEQGQDRSHEGMEIEALIIPELVQLHSSMVAKHDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP45</accession>
    <name>A0A5N6TP45_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1750-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_159052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP45"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="74664" checksum="8996568E2589AEE3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPS7</accession>
    <name>A0A5N6TPS7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_158472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPS7"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="30"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="472" mass="52473" checksum="1E209CB60F3B5615" modified="2020-04-22" version="1">MTAPAASAPSPGTTFKDMRKGFFIAITASFILLQLLFLGNLSYLYGTQYKDSTRFHNLNVLYVDYDGGVVGQSVLDAYQILRGESFPSLQQSPVTDYPALKDVKRAVCKGDYWAAVYTSPGASSNLTSALTTGTSAPNSLTYIWNGARYPAFSQSAIYSSIMSLIQVTRSTYYARNASSMIASAPFSSNAAALQAFLDPIKAKEINIKVTEQGTRVLYNTVSIVMPIIQQFFFMMALNGISAQFRLYSKLGTTSNGLLRMCISILYTFIGSLCMTGYIWAYREGWEVSGNHFALTWMIIWLYMHINFIIVDILTAFVPMQFLPFCILTWAIINVASTISPFELSPGFYRWGYALPAHELYQVLVQIWSDGCEDQLYRALPIMFSWWMAGLAVVNFAMRHRCQTALAAEAAATPSDADARSSEDTKRAPSLSRHSSKQKIIPQPRQETAESIRLENLAYAPSYPPSIVRGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ42</accession>
    <name>A0A5N6TQ42_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_158201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742159">
        <property type="protein sequence ID" value="KAE8148473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000745">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000645">
        <property type="entry name" value="HEAT repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000886">
        <property type="entry name" value="HEAT repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laa1_Sip1_HTR5"/>
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    </dbReference>
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        <property type="entry name" value="TPR_LAA1_C"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1872"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2054" mass="224408" checksum="2B5E945030B24746" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ44</accession>
    <name>A0A5N6TQ44_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_20359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39466" checksum="F406CFC27EE97829" modified="2020-04-22" version="1">MAPNRLLLVSYPRTASNLLLQILSLKDQPNVLANDHGGYFFMRAFMVAAQESRTYRPFDQWTPEECKEVQTTFQECMDAMEEYSERAQKQGKMLVTKEHAFWLCNPMAFSRMIHGTNGEHDDLFRVQIPAAYGPSQTYSPNNQTVFSDEYLRTWRMAFIIRHPALVFPSFYRAMLKMVAANVLMKDELPGVLETNMSLQWTRMLYDWGMENSDPESQPLLLDAHDVIHNPEVVIRFCERVGLDPNALKFEWEKKADANAEPAPEQRAVPDQRVSIQTEGARAIMLGSLAGSSGVLKDKAPTHIDVAVESSKWKKELGEEAALLLEKTVLAAMPDYEYLKKRRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ74</accession>
    <name>A0A5N6TQ74_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_158258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742160">
        <property type="protein sequence ID" value="KAE8148450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ74"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="237" mass="25715" checksum="75B5EEF3B8C25CE9" modified="2020-04-22" version="1">MEQKHTTSIPSSNPPSVEVAYKRKCIALKKRLSEIEAENELMRTRNRRGWQYIQKMRLESCILLERLSKVTGMAEEAQAGVSPELRARAAAMMSGASMDGAKDGPPAYEDETEGSSDEQPPTPQERPLRVKRSRKSNINDAGDDDTAPPPSGNGDGSSLPRLAPAPSQDDLTSSFRIQAGNGSAQEKDEKEQIGSGSDRGSQAPEESGPKEKETGEDVSAEPTTPMDMDVKEPKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQU5</accession>
    <name>A0A5N6TQU5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_13244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQU5"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="380" mass="41742" checksum="4BD343D4A29C1D69" modified="2020-04-22" version="1">MPSSPQSHLPTEIIVQIISYVSADNRDRQKTLHACCLVSHQWYSAAVAYLYERPLVNTGIAFQRFTETISPPLGARKNKLNLGSFVHRLNLSHLVHHSSNSLTARLLGRVKGNLEVFAAPSLTFTISSLPALSKCLNLRNLDLSLVHDPIPFPALKQAISKHKKLTTLRLPQSTILTEPESARIPWPPSLQRLQISGRFNPLLIPTFSWPPALTSLALKNCSDLSVTNLGSLLSSPQLGSTLRRLTISGANRGVQPESINAIPAFLPNLTFLSVPGDMVDESFFDIICHMFPPLALTVLEFGLPCADLQLNFSTKSLVNALKTGLTNVREVGFANELVTDQLATEHDEIDDVLRQLEEHRVSQSGSGTQDEAQIGVYLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQU7</accession>
    <name>A0A5N6TQU7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_168243</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQU7"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="50"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8148738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="405" mass="46101" checksum="3F67A25658D475DE" modified="2020-04-22" version="1">MSLWKNYFGLGEVASSGTTPPMADKPLPANWYTSSEMWELERRAVFSRQWILISHSLRFSKTGDYLVYRIAGYPIILVRDRQGNFNAFHNICRHRAFPVVTEDKGTARIFACKYHGWSYGLNGNLAKAPGYQEVEGFDKSKNGLFPVHVHVDNHGFIWVNLDAQEQPEVQWEDDNNRIQLQKRFTGIKWDEYDFDHTWEMEGEYNWKLLAVLRTSHLDTEGGTIPDTSEAIARDLKDATTYYFPNTSLTVTPHYFFMQRFVPSSATKGTMRYEFYRNRNSGAEVELINQTYQHIMTEERDLCTQIQETLKSGEIHARLETGPFDLQNTVREIVTKHHNKEQEAGKPIWPARQVLPSTATTSSEDVDFCNKLEAKAKATSGGCGAPECCSASGGGMSCGTNEALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRD0</accession>
    <name>A0A5N6TRD0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_141393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRD0"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="189" mass="20993" checksum="5BB4C9B62AF72AD9" modified="2020-04-22" version="1">MTAAAKSAIAPPKRANTDYPLIDSDPHLRRVFRYARPSDYAVAGSAAAASPLAFWAMERVSPSHVGKGGFAPVMRLATAIGLIGGLHVLYQRSCNRFYGFTENSREVDMDMKEMVDKVKMGESLYGTSNVSTYLQGVAARNSRYSELFIHVLPWFNIVNHDQHGVDTAKYYQQAEQELEAERLAELNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRJ1</accession>
    <name>A0A5N6TRJ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_141343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742142">
        <property type="protein sequence ID" value="KAE8148910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRJ1"/>
    <dbReference type="OrthoDB" id="4390634at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="290" mass="32467" checksum="2A66821A7A0D91AB" modified="2020-04-22" version="1">MEMVAPTDSTTRLCSHSCHSAHTGSDRHHLPLCLMRVTHAGTADGTVRPTPGLSADGSLQPRNCSRRPIYRSEIRSHMNPESDRGSRLTSVATWSLLSSLIYKWQEQGVRDLRVHVIFTPLFSKDTQVYKATGLAEHHSLNQECYCGEEYLIRGRIRPDAIIKSFPVEGKGVLMNIPLFGYQSPFSSVRGDSVPVALPAAFFAMQDDISDPDYELVDFVQNPAARLQFGSTKEVLCRVLLDMLSRGCLFSVTDWQRLTHVQPMPSDEPFGLRYKWLGHEGDNFVACTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS03</accession>
    <name>A0A5N6TS03_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin cytoskeleton organization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_156866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742133">
        <property type="protein sequence ID" value="KAE8149136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS03"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="225"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="833" mass="90297" checksum="BFD92B61C5913F1B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS23</accession>
    <name>A0A5N6TS23_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_156877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ML742133">
        <property type="protein sequence ID" value="KAE8149145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS23"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="264"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="635" mass="69806" checksum="52D203AC537B1E02" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSN4</accession>
    <name>A0A5N6TSN4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:flavin oxidoreductase/NADH oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSN4"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="368" mass="40428" checksum="204B1F0BC2E14710" modified="2020-04-22" version="1">MSKLFTPLQVGRVQLAHRIAMAPMTRFRVDDDHVPLPMVREHFEQRAAVPGTLLISEATVISPRAGGYANVPGIWSPEQIAGWRSVTDAVHAKGSHIYMQIWALGRVANEDFLKKDGYDVVSSSALPFGDGAVPRPLTEDEIQAYIGDFAQAAKNAVAAGFDGVEIHAANGYLIDQFIQDNSNKRTDKWGGSVANRARFAIEVTRAVVEAVGADRTAIRFSPYSTFQGMRMADPVPQFEYLAGEIAKFNLAYVHLIEPRISGNADVDVSEADSLRFFVEKYEKAGPIVVAGGYKADSAQEAVDLLYKDYDTVVAIGRPFTSNPDLPFRVKAGVPLRPHEREKLYIPKSPVGYLDYDFSEEFKTAQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV2</accession>
    <name>A0A5N6TSV2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_156374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSV2"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="43886" checksum="847B52F4919B59D6" modified="2020-04-22" version="1">MLSDKYIGLILAILSTMAIGTSFVITKKGLTHASERHGFEGEGYSYFKSPIWWGGVITLAIGEIANFAAYAFAPAILVTPLGALSVLIGAVLGSYFLKERLGILGKLGCAMCLLGSVVIVLHAPPDKPVETIEEILHYALQPGFLLYCLAVAIFSTVMIYRVAPVYGKKNPLIFISICSTVGSVSVMSVKAFGIALKLTLGGNNQFSHASTYVFMIVTGFCILTQMNYFNKALNQFSTSIVNPLYYVTFTTATLCASFILFKGFNTTDAVNTISLLCGFLIIFSGVYLLNLSRHDPDGRQMLNSKLDDEGVPTDGIASFQTRRSMQSRRSNEPHRRSSSSLAFLNSNGDREGLIHAYDVENQAFGLSELAEESDGEPGPTYKNKRSDDLERTSHQPNKPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSX5</accession>
    <name>A0A5N6TSX5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSX5"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="647" mass="71103" checksum="6E1BCDCDA77334F0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTH7</accession>
    <name>A0A5N6TTH7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">feruloyl esterase</fullName>
            <ecNumber evidence="1">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_172741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="1"/>
    <dbReference type="EMBL" id="ML742118">
        <property type="protein sequence ID" value="KAE8149607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTH7"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="291" mass="31153" checksum="0C243882A31C95E4" modified="2020-04-22" version="1">MHPKHLLPFITLGLSAPTLSPRDIPPSFLQTLTLYAQYSAAAYCPDNSNSPGTKLTCSAGNCPLVENADTNTLSEFEDPDRTGDVAGYLAVDKSNKKLILAFRGTRSIETWVANVQMGKEDAGEICAGCEVHSGFWKSWSAISEATLDAVRKAVEAHPGYGIVVTGHSFGGALATIAAAVLRNLKIGGSVDMYDYGAPRIGNSEFAEYVSAQGANYRVTHANDIVPRLPPKMFGFHQLSPEYWVHAGNGEAVGTGDVVMIDEADSKMGNRGADMPGVEAHKWYLGKIDACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTR5</accession>
    <name>A0A5N6TTR5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_155828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742115">
        <property type="protein sequence ID" value="KAE8149697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTR5"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="255" mass="26587" checksum="0FE43BC2E2ED2BFB" modified="2020-04-22" version="1">MGFSDILKDAVSQAVEQHSSSSSNNNNNSSSYGENQGSGSYGGQQGYDRPPSHGHGEGSYGHQGSYGGGGEYNDTRYNAPPPSHGGYNSGYGDSSFSQNEALSHAESHHGSSGDSSLFSSALNFLKEKQGRSSSPDIDESQMVQSHHQLYNEDSSKSHNSDSLGAGAAMQALKMFTSGESGSSGGDKNAFIGIAMSQAAKLWEQKNSSGAVQDDKQSAVNKAAEMAMKMYMKNQGSGSSGTGGPALMSLASKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU62</accession>
    <name>A0A5N6TU62_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_120083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU62"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="418" mass="46311" checksum="7871DFF9B7503854" modified="2020-04-22" version="1">MARPTQRYACDRCHGQKLRCIHTEGGPCLRCAKAKATCSWSQSLRSNRPKRQAGSMSETPMDTASTTESASSGSPPFGVYMTQPPTPADGDPNMPQFPFTPRLAWGPHPGNYPSPASQEPEPNFNVVTTEGDMQVTPDWMWPEVANCPIQTPPPVNWQQSFHQEWAMMASQHPGAVMEATPPESVSETAEVPKPDCLLATIRDLSELNVELYAHEARVPKPPASLAEPLSWKDKDFAIDRTFQLSQRLIEIVNKRYPRYLETARMENSNVPPEGMPPGPQVDQGSCLLILSCYTRLILTYDRIFENMQGCLDRSSITAREDYVHMPSVQVGSFSLPQSSSLQIVLILQLARQLLTRMGAIIKAVQPQQQENYTEVPALDPGAGGVLMSSALETVSVEEDHLMKRIAKLRSTLIALNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU85</accession>
    <name>A0A5N6TU85_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_155623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU85"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="53386" checksum="F40582173FA3FFF5" modified="2020-04-22" version="1">MDPPETSQKLPEKDIVSPNTVPIDAPPLEDPQKGRWERSWPTIACGAGLFSDGYLNGVIGSVNTILSTIYPHSYKNSPASQNVASITFAGTVLGQLVFGYVSDHWSRKWSLMISTIILIIFSALCAGAYGLHGSQYGLFAALTAYRFFLGIGIGGEYPAGSVAAAENTGELKKGHRNRWFIMFTNFQIDFAYVVSALVPMILVLICTENHLRAVWRIALGLGVIPPLSLFYLRLKLNEPEEFNRERMHKFPFWLIVKFYWKRLTVVSLIWFIYDFSAYSFNIYSSKWVGIILGDSAPLWKTFGWTTVTNAFYIPGSFLGALVSDWIGPRNTLAIGVGLQGIIGFVMSGCYEYLSIPKNVAGFVVVFGIFSALGEFGPGDNIGLCAAKSSATAIRGQYYAIAAAAGKIGAFVGTYVIPIIQNNAPNEVRSGQDPFFVSSSLCILSAALAFFLLPQIGQDTITDEDAKFRAYLEAHGYDTSTMGNPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUJ5</accession>
    <name>A0A5N6TUJ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_155187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUJ5"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000088">
        <property type="entry name" value="Chitin biosynthesis protein (Chs5), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47756" checksum="FD3B5B6BFBCBFEEF" modified="2020-04-22" version="1">MLVSLTVGKVDAGVAVLLTQDNRLIEFPSVLLPNNITSGSIVDITVARNHSAEAASAAGFQSLQKRILNTYGVKTPSPPILRLRNATQTSLVLEWEPIDLATASLKSLSLYRNGSKAGSIPRPLETRSTKISGLAIHTEYTFHLVLRTTAGTYQSEKLTCRTHKMTDLSGITVTAGVMPPQQKEALAAALDRIGGKLIDTVRIDTTHFVCTEGRGPLWEKAVEMNIPVVVPEWVDACEAEGTIVSVRGYYLNADPKARQLGPIHASTQHQRTMSTVTTLTTNHRPQSQSRLNFQELNSPQRPSQERPESVAEPPITPFPGADMSGQPKAEDSEPPSDDELPPPPPPPKDEEAGVSEPKEAKEPTPNGHAEPNGDSNTNTTDTPATSPPKVEEQEIEEDETSDVEKKESAQNKESNTTEDSSGDEVTKGKGKEGEGDFNEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV63</accession>
    <name>A0A5N6TV63_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_154918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV63"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="151"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8150187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="36309" checksum="771B293E8A6924E3" modified="2020-04-22" version="1">MSSPPQGPKPKSAVPSRLLNGTPALTPTNSRGARERESLNSSIRSSFAPRIPAEFNMPETVVHPVDDATDNADGAPSSSGAVKPIAHDQSRESKDEAGALTPPSTASRPASPYTLYPPIDFDGLSWPCPGTRERLEASPEENEERVQKLAGAVRTILECIGEDPEREGLRETPERYAKAMLYFTKGYEENVRDLVNGAVFHEDHDELVIVKDIEVFSLCEHHMVPFMGKMHIGYIPDRRVLGLSKLARLAEMFSRRLQVQERLTKQVALAISEVLKPLGVGVVMESSHLCMVMRGVQKTSSTTTTSCMLGCMRSSAKTREEFLTLLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV65</accession>
    <name>A0A5N6TV65_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV65"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="178" mass="20133" checksum="57DC78CC98CFEE90" modified="2020-04-22" version="1">MTDHTLFFYGTLMAPQILHRVIHGSPTPEKWQRDLLTFQPAVLHGYKRHRVRGADYPGIIMGEENLSGGAGAGVWGTVVSGLTDGDVYRLDLFEGSEYTKERVRVRVLRMETGEGKDDGRLREVLDGAGEGAEEGEEVDAVTYVYVAGRERLEDREWDFEEFKRDKLAWWVGADLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV94</accession>
    <name>A0A5N6TV94_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV94"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="392" mass="43949" checksum="A3FC06332E53A966" modified="2020-04-22" version="1">MEKSEILVHISAPCRGSDDVRYRAQVEAILGFQTVSRRVITLKPDDEVGEEGAITAATRDRLLHPQSQYQSHCNNIAPQEHGLPVIDASNRPPTVISNETIAPDEQSLSNVQPHSCFRNDSLDSPVSIIPDSQPERLPSDTGNLQDANQQPVPVLDLYSTDVIPPKRGSQTTLSSSQQSVKKTRRDPHNANETNITQRGESPTHSHLPPAQNFPLSLPAEIRPPLPPISKEKFITHVTPTLEMLATRLKGRTYNPLHQTREPGALERGHWCLRIDILQSVAAEDLTVAPNRTNGVQTWDISLFTRFWAFLSQFIREGRAGWGIWCIVEDASDPQLSHDAFKPTVRQLTLKIYTWGEVASHIYLMLYLASERHIRKMGAQWRDGCNEVVVQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVV2</accession>
    <name>A0A5N6TVV2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_139751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVV2"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="225"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="406" mass="46062" checksum="D100885F25747087" modified="2020-04-22" version="1">MAANTRQPIDIDSAASQCQKVLGYIEKYRADAKEIDRERAVEAAAVLVRLLEQPADAIYKLFLSPTILMAVKTASDLGIFSRLCDGDAFVTCKELATPKGADVQLIERIMRALVCSGFAAERGPGQYMPTRRSKAMTARTVIGLMDSLFVDFLPIIHKTPEFLRETDYRNPEDPTHGPLQYTHKTTSTTWDWLSKRPAALDRFNSFMEGNRAGRSHWAEWFPVQERLLDGAVVNKSPLLVDIAGGRGHDLIKFKQRFPGPHGDLVLEELPAVIDDISNLDEDLRRVKHDFFQPQPIKGARVYYMKHVMHDWSDGNCRIILGHVVDAMERGYSKLLIEEHILPDQHAKELETLRDLIVMVWCPGNERTRQRWTELLESVGLEIQNFWLPDGFGTGIVEAVLKDDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW31</accession>
    <name>A0A5N6TW31_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma interferon inducible lysosomal thiol reductase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_154097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW31"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33003" checksum="C69DCE47FFC43AD6" modified="2020-04-22" version="1">MEKSETPTHERYEYVPVSTPPDGDAVRTRRGRSVARLAMGLSLVSLLLLSSMLFALPNIHLHSCHKAMSKLREGFLSPFTGAPQKAPIVVSSSRKVPLEAHVMSKCPDAQDCLQQLVVPAMERVSEKVDFDLSFIASVSNQSSDIDCKHGPGECIGDMLILCAQNLPFSSEDDGGEVSRMPVIRSLGFANCLISSYPEIPDRTLAQNCALQHGIDFEALNSCVSKQEDETGNDSLSGLALLRKSALHSAELGVSTSCTVRLDESVWCVRDSGVWKDCAHAGEASKVSELVEEIEKLWDQKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWF4</accession>
    <name>A0A5N6TWF4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_153912</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWF4"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="229"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8150723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="46456" checksum="68EC7F16ED9513AC" modified="2020-04-22" version="1">MTSIARSIPIMSQEPWTEICAHCADLISNIPPTVLLSALVATSLGAFVLAYFVLFIVAPVPREPLPEEKKYRALSKDGSITEPQQLPCWQESLKRTNKAPDHSAMEQPDLFMSVVIPAYNEEERLGGMLEEAVNYLERTYGTLRDTVDENKAETTTRQRKPVNGHVNGHATSDTTQKGWEIIIVSDGSKDKTEDIAFAFARDHQLSLHPKGYAGPWTPGTQEGVHIPPGTIRIVTLTKNRGKGGAVTHGMRHVRGQYVVFADADGASDFQDLGKLVSACQGVEDSEGRAVAVGSRAHMVGSEAVVKRSKLRNFLMHSFHLILWLLTPSQTATIKDTQCGFKLFSRTSLPYIVPYMHSEGWIFDVEMLMLAEFAKIPVAEVPIDWREVTGSKLNVLRDSIGMAWGLAVLRAAWSLGVYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX17</accession>
    <name>A0A5N6TX17_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX17"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="340" mass="38842" checksum="86073ABD4E0B7809" modified="2020-04-22" version="1">METKALAKRMVLPDDNLGEFHEEGMPKRTKPILFKKSYKRATDTSAAIMHEFSRARPDEFSTGVEGLHGCTTMYIISRKAVYITHWWENVAFDADMLELTVFDLLRNGGKYYHKLDASIIEDDYIHAYMIHPTQAFRQLKDPSQSDYTDQWNQIRTVVGELVPKLQDQSRWTDVPYIRVPVDKDLDEENMVRGKNLFKYNRAQSIGGGQTQQWAMMYHEPPALLPARGFKLNKFSPTSITQYQGELSQLSCTIAPEYNSFIRAFHSACSASDLLKVQETLGCQRLLKIADLSMGLALATHRAHTDLVDVLFDTDARVAQMANNYLPGDCKIQQDPRISIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXI7</accession>
    <name>A0A5N6TXI7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_153416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXI7"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000649">
        <property type="entry name" value="Compass component swd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000614">
        <property type="entry name" value="WD domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="483" mass="54214" checksum="49F9EBE4E73915A1" modified="2020-04-22" version="1">MNLSLVDPFVLAQDYPDTLTEKLRSGHATCLRFNRKGDYLASGRVDGTVVIFDLETNGVARKLRGHTRQIQSLSWSRNGRYLLSSSQDWKCILWDLADGSRVRTVRFEAPVYIAELHPYNHLLFVASLFEDQPVLVDISSPKPIKRILPSAPFRPPPPKSEEVDPAVAAKQAAQDAKHSTCVTIFTALGNHIIAGTSKGWINIIETQTCVTIHSTRLCNGVVILLRLASNGRDLLVNSSDRVIRTILMPDLSQLGIDLEPASIKLQVEHKFQDVVNRLSWNHVTFSSTSEFVTASTFMNPDIYVWERSHGSLVKILEGPREELGVVEWHPLRPMVVACGLESGCIYTWSIVTPQKWSALAPDFGEVEENVEYVEREDEFDVHPAEEIHQRRLDQEDEVPDVLTIEPHKSDADEEVEMESFRMPVLLDISDSESEEDIVAVGPGTMRRRSPGAGRDWMNTNENGEKETTGGKNGTSRGQRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXP9</accession>
    <name>A0A5N6TXP9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXP9"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="282" mass="31463" checksum="2142990DC8412B09" modified="2020-04-22" version="1">MEAIVKENTLIRGTRIAYSTYGEGAPVVLLHGTPSSSLIWRNIVPKLSSTGFKIHVYDLLGYGLSERPWDPSIDTSISGQVPVLEDLLTYWDLKSAHIVAHDIGGGIAQRLAVFSPEKVRSVTLIDVVSFDSYPSARTRQQMQQGTESLLKLPDQQHREHYREWLLSAVQKMGPFETSSLDTFLGYISGPVGQASLYQHQVRHYDPTHTLEVADRLGEMGKIPVKLIWGCNDAWQSLSWAEKLRTSIPGSELVVLDDCGHFAPEDQPELISKLLIDFLKGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYA0</accession>
    <name>A0A5N6TYA0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_139015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYA0"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="214" mass="23723" checksum="A328A159AD31342A" modified="2020-04-22" version="1">MSPPIRTTILISGNGSNLQAVIDSQLPVHIVRVLSNRKDAFGLERARRANIPTQYHNLVKYKKRHPATPEGIQAAREEYDAELARLVLDDRPDLVVCLGFMHVLSPRFLGPLEGGGLCIVNLHPALPGAFNGAHAIERAHAAWLEGKIEKTGVMIHKVISEVDMGTPILVREIPFVKGEDEDLEKFEGKVHSIEWEVVIEGVQLTIDEIRKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYC0</accession>
    <name>A0A5N6TYC0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Late endosomal/lysosomal adaptor and MAPK and MTOR activator-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_138899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYC0"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17932" checksum="FBBB9AB96FA2FB51" modified="2020-04-22" version="1">MGVCASCLGRGRRETHDSESSRLLDDEIYQPGYGGYGSLNNSSNQLNNADTGYLRREREALEAICQRTSDSVIDIWSLQPQPHLQPQATLRGPVSPASSRGDPKDDVPVRVTRTPPESGPSQQPSPSQPGAVPKHWGEVVINPRKGKVQSVDTSSRDVFGVLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYK1</accession>
    <name>A0A5N6TYK1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYK1"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="16"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="460" mass="52868" checksum="739766B4B921798E" modified="2020-04-22" version="1">MGHKKDEKKKKKKGGRRLVLCFDGTGNRFNADESDTNVMKIYEMLDRQTDRQYEYYQLVAGIGTFTTGSSGSALGFFGRMKEKFETILDQAIGTTFQYHVCKGYEFIMRYYKPGDYIYFFGFSRGAYTARFLSEMIDVVGVLSKGNEEMIRFAYATFAEYIKASGREPTADDLKKKSYRDSFKNTFCRPDIKVYFLGIFDCVNSVGQFEVPFRRAPYHFTSTPSAVHIRHAVSIHERRLKFKPKLCLYKDSSDTVDLKEVWFAGNHCDVGGGEKYEHGQQEHLLSDTPLAWMIDEILALDDDPDAKLCLDMSSIANSGHLHAGHERLMQLHRNPEKCHHEVVNARRPHDYLTYGRGEGWLMTTLWWVIEILPLFTRLELEHGRWIPRYWPPNLGASRDLPDDAVVHPSVQAMHHANDPLRVARSLLPWNLKKPASIDLLGTSVGTKVRESRGAHQWAWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYL3</accession>
    <name>A0A5N6TYL3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="7" type="ORF">BDV25DRAFT_128831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYL3"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="432"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="777" mass="85205" checksum="8652120DDDA53A74" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ77</accession>
    <name>A0A5N6TZ77_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_152740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ77"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="46782" checksum="6C9E3E9B4CD7E6BD" modified="2020-04-22" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFEHENPEKVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWVEKKRKEEAALATAEGTTEAGNDDDDEDMKELKPRENVKIVSIDLQPMAPLEGITTLKADITHPSTIPLLLRALDPEAYDSTSSSPSTLRQPHPVDLVISDGAPDVTGLHDLDIYIQSQLLYAALNLALGVLRPGGKFVAKIFRGRDVDLLYAQLRTVFEKVSVAKPRSSRASSLEAFIVCEGFIPPAIHDGSMGMDALKNPLFGGVAVPTTASADGNVGVEVMDIDSEAKTEPVNLTTAKTISSPGPHKENQVRMLHADTNATSTQEPISQKPVTEKFALENRWIPPFIACGDLSSWDSDASYSLPPDHVSLDPVQPPTAPPYRRALELRKEKGGAYGKTKLGAMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZX7</accession>
    <name>A0A5N6TZX7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_151913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZX7"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="251"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="58027" checksum="7F0A1867D099F929" modified="2020-04-22" version="1">MSDDDFMQDSGDEEYDFEYEDADEDDSGDIGIENKYYNAKQMKIDNPEEAIDEFLEVPALEQEKGDWGFKGLKQAIKLEFKLGRYSDAVEHYRELLTYVKSAVTRNYSEKSINNMLDYIEKGSDDDKAYQCMEEFYSLTLRSFQNTNNERLWLKTNIKLARLWLERKEYGQLSKKVRELHRACQREDGSDDPSKGTYLLELYALEIQMYAETKNNKRLKALYQRALRVRSAVPHPKIMGIIRECGGKMHMSEENWEEAQSDFFESFRNYDEAGSMQRIQVLKYLVLTTMLMKSDINPFYSQETKPYKSDPRISAMTDLVDAFQRDDIHAYEAILSKNPDVLADPFIAENIDEVSRNMRTKAVLKLIAPYTRFTLTFISKHIKITIPEVQDILSFLILDKKLNAKIDQENGTVIVESASDVDRLRSLEEWNASLRTLWRATLDGEGFKSDEASQLHGMRGGPLFQSGFGDEVPPAVGLRPTNRRLRSGWKGKGSHGTRATGAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0K6</accession>
    <name>A0A5N6U0K6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_76747</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0K6"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PIN_dom"/>
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    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
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    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
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        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
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        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF17215">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
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    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="85"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="520"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
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            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115972" checksum="FCF1ED083E859410" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0L7</accession>
    <name>A0A5N6U0L7_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_151549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="31"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="57" mass="6604" checksum="218DFD830D03C2AC" modified="2020-04-22" version="1">MTLYRSLEKKRGVAVKRIKDKQAREQRKAANGSTSSSPTRFSVVQTNWEVQPERIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0N9</accession>
    <name>A0A5N6U0N9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_170711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8152197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37299" checksum="9C06BF7C3D540C46" modified="2020-04-22" version="1">MVAIQTIRSSNANLKALNNITALFVGGTSGIGQSTLRQLARNTNKPTAYIVGRDHGRAKPFLSELKQLNPEGQFNFIEADVSLIRNVDSACQEILKKEKHLNFMFMTPGGISLGGRNETTEGIDYLFALRYYSRMRFIRNLLPLLETGKPSRVVSIYGGGFEFGIDLEDLDLKRNFSLLNAYKHSITMTSLSMEHLAQEHPNVSFIHAYPGLVGTNIYTNSFPAPISTFYNYAMWPLMWPFSVNLEESGERHLYHLSSARYPARAGTTDQGVSCQTGDIATGTTGEIGSGSYLLNWKGDVQPSRSMLKEYREQGIPERVWKHTEGLWEKAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U152</accession>
    <name>A0A5N6U152_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_170581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U152"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="394" mass="43622" checksum="D51A9AFB01B6C913" modified="2020-04-22" version="1">MSPSPIAIIGAGPCGLTFARLLGQNNIDYIVFERDESAIPMPHQLGGTLDIHGTTGQEAIKRAGLFEKFSQLARWDAQSFVVQDPTRAINRKFSGGRDAPEIDRVQLRRLLLDSIPAHKVRWGHGVKRVEKAADGDDWIIFFSNDTTASNFRLIVGADGAWSKVRPLLTPVKPEYSGKLFIQGRISHDNPRYADALAQGGRGNMMAIGHGRQIGVQQVADGSYQVHMGILAAEDLTKTTLNVSDTEGTRRQLLSSPNYYPGFAPELRDFIANAEGPFYAWRLYRMPVESMSWKRVPGVTLLGDAAHVSTPFAGEGVNCSMFDALRLVDCVLKYCGSGYDDDQGNMEQAVMEYESEMFVRAKDLISRSMAFEEIIYSDDAARRLVAAFDEFGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1A1</accession>
    <name>A0A5N6U1A1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Pex12 amino terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_76794</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1A1"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="84"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8152149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="469" mass="52431" checksum="4B8926F571CFBF26" modified="2020-04-22" version="1">MSSTNFAAAQERVLERRRLREAEARVIFAEQQQAWPVNHPAIQRLPAPLNRIPLSGLSLWNSIKGREGNRPAFRVGQVDAELLDEELLGLLKGQVGNALKYFGPQAREDWSNEIQLALRAILFKLSIWDHDASYGAALQNLKYVDTRSKGPIHSAPTKWQKSVYGLLTVGGRYVWEKWEGWLINQESGYEEPSREVRMLGRMTDLVSSAHSIAAFISFLVFLVNGRYRTLVDRILRIRLTPPSAQASREVSFEYLNRQLVWHAVTEFLLFLLPLVGISRWRRWLSRAWRKTVSSLKSSDDDHEESEKRGELSFLPERTCAICYKENNPESSTENEVMAASAASGGIVGSAQTDITNPYEAIPCGCVYCFVCLVQKVEGEEGEGWVCLRCGEIVKKCKPWHGDVLEEARPQSSSGKIVGFAIDENSGANTTGLGNEAGNSGGRSSPLQDSITDETLQHSSQWSTIDGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1E6</accession>
    <name>A0A5N6U1E6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1E6"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="512"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="624" mass="68300" checksum="05CF5EC068A663D5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U258</accession>
    <name>A0A5N6U258_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LEA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_57412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="13748" checksum="BCBF431AFCEEF8BF" modified="2020-04-22" version="1">MSFLTRFTPLTARLGSVRATAAPALVVGARSISATAGLQKGPVEATKDTLKKADRAVSDAAVEGIKKGEQAADAIKGTANKDSGELKGQASELAGQGKGKAEEALGSAKGKAEETLGEAKGKAQEAKGKAKEKAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Secreted protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_150613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025033964" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8162" checksum="063A39F9106A5036" modified="2020-04-22" version="1">MHHHHKINAITLFFALHSSRVDTQSPNQKGDYCCSGKLVEQTRCIICSFCLMGVLKGIMMDHSEKWVWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U2H9_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_150752</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="131"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="269" mass="29936" checksum="75C65348A66585F8" modified="2020-04-22" version="1">MKNPVHIMTALIRKLRKRKLSSELHSRWGDVSITYPNAGSWSQYDQIAMGTPNSFPSNPPEQTRRHGSLDSLDRRGCSSQNLTRSFSGDTEERTPSTDSAMTIPTGHYDAKLRGRSKKKPATSSGSKLNFRSDLKLRKSPVDSSCDETDDSISSLSSLKRRYHKESSRAMGQENDVYARASKSPPLSVTSRMRRCSLQSTTTEPTPSMPTSSSKHTSYTSSVPSVPSEDPRVGYQPTAHDKRYSRRSKPRDPAPSTAQELVPSYDELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2N2</accession>
    <name>A0A5N6U2N2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="654211at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 33A"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="786" mass="88396" checksum="2A034B3269902B2D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U330</accession>
    <name>A0A5N6U330_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">BDV25DRAFT_137288</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="555" mass="63734" checksum="3AB530AC9185B626" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U353</accession>
    <name>A0A5N6U353_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U353"/>
    <dbReference type="OrthoDB" id="5333491at2759"/>
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    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="442" mass="50798" checksum="2394611D442584F2" modified="2020-04-22" version="1">MAEIKAYSTDLDMFRQVFSSPQRRNLLRTLHYEIDLPTYSKNRIFCLERRREHRANNESFTRGMRDLYDVIGSWGMHGIDLTLVASSPMDPGRRPPELEPGLMHERWSFDDNYLTLDEVSLPQTQSVEALRIANGARSMHPSAIGRIISSLPHLQRLALELNAPKAKRVEMQDEHRSCLAHALVSTSLSNLRTLNIYIEQGIPSNHNFQNRPYDPKYPNGDILNAAIRQLAENTHLTNLSLTGDWLVSPELFNGEKTFPYLEKVNIQGALITYDGRWYYTGNPTDIEASYENIRDDVDDGSDSDSNSSFNSKGGDPLPEGREALLNGHEPYHMWRTRPDPQMFDPLMKIMATAIPRMPSLQNFRFSMGTNSMFYHGIIFEYLKPRQHTEWFEYPRSLAEMDKIRCYVTCMPEARWDVPGDVFALWKEVVGDRGAVAVETFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3M5</accession>
    <name>A0A5N6U3M5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_127387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3M5"/>
    <dbReference type="OrthoDB" id="4243861at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="156" mass="17893" checksum="A3C8D2B658D10FDA" modified="2020-04-22" version="1">MEETIRRFLNRFDSSLPVPSIRVVGDTPNSILDPNDFLESITSIVEGVKSAVIACRPQTQTCYLAVKRFGGRHSFFVLDLNNVEYDYDSAHENRSPIPVYILRLSRNPKIFRHAPQDQQLADKLAELHNLHGDDPLPLFDDHTKPIIYAFPRYLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U3V9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_137022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="407275at2759"/>
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    </dbReference>
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        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="607" mass="69531" checksum="4827D3F1CD5F09AC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4F1</accession>
    <name>A0A5N6U4F1_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_149290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4F1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
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    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
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        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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            <end position="31"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="376"/>
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        <location>
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            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="202"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="554" mass="59968" checksum="C89E6474720559C5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U530</accession>
    <name>A0A5N6U530_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Necrosis inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8153640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="235" mass="24746" checksum="72ABA665C7E8991B" modified="2020-04-22" version="1">MYRSILATAAAIGLTNSAIIPRASIDHDAVVGFDQSVPSGTTGDVYLAYQPYLKVVNGCVPFPAVDAEGNTNAGLAPSGDSNGNCSSSTGQIYVRGGASGDYYALMYAWYFPKDSPSSGLGHRHDWEGVIVWISDSTATTAENIVAVCPSGHGGWDCSTDGFTLSETKPLIRYYSDWPVNHQCGLTDTVGGTQPLVAWESLPSAASTALENTDFGDANVPFKDANWDANLGKATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U535</accession>
    <name>A0A5N6U535_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_136645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U535"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="56673" checksum="C085D662D88E4E90" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U557</accession>
    <name>A0A5N6U557_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_126986</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U557"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
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        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="535"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8153777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="773" mass="86090" checksum="A72E28F5A09037CF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5S0</accession>
    <name>A0A5N6U5S0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_148343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5S0"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153938.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KAE8154243.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64182" checksum="83A5DE805006DD47" modified="2020-04-22" version="1"> </sequence>
</entry>
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    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="61" mass="6178" checksum="0DC2EC9CEC56A89E" modified="2020-04-22" version="1">MKFLVLVSALVGMVSAAAIAQPELVERACNPIYGDCKVDGDCCGSLTCFTHAAGGGNCADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6P9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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    </reference>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A5N6U6R7</accession>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
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                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Henrissat B."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
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        <property type="protein sequence ID" value="KAE8154292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="130" mass="14364" checksum="6C8BB244D23B5EEF" modified="2020-04-22" version="1">MPLITDFALPASPKHLELPEGTDAKAYLVFVTSDDPVTGQSWCPDVRAAWPALEATFSGASAPALRVVEVGQKPEWKDLQNIYRTNWKISCIPALVRYERVNGETVETGKLMEGEILDKKKLGEFMGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U748</accession>
    <name>A0A5N6U748_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_109608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U748"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:linear primary-alkylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.30:FF:000001">
        <property type="entry name" value="Alkyl/aryl-sulfatase BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="entry name" value="Alkyl sulfatase, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.30">
        <property type="entry name" value="Metallo-beta-lactamase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052195">
        <property type="entry name" value="Bact_Alkyl/Aryl-Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223">
        <property type="entry name" value="ALKYL/ARYL-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223:SF1">
        <property type="entry name" value="ALKYL_ARYL-SULFATASE BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="103"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="630" mass="69469" checksum="83C021EE14523AEB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U792</accession>
    <name>A0A5N6U792_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_147673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U792"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="710" mass="81295" checksum="7BF2C6BE9145489A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7G7</accession>
    <name>A0A5N6U7G7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAN-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7G7"/>
    <dbReference type="OrthoDB" id="4462933at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006583">
        <property type="entry name" value="PAN-3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08277">
        <property type="entry name" value="PAN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAN-3" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="290" mass="31892" checksum="9921FE22AA8F9A7B" modified="2020-04-22" version="1">MRNAASWTWRAGPHRLQLDQYFRKNYKGAFRSRGVLVRNADAAHSSVRSRRGNHSWKRLLFQLALADFAAFCPSKDSQPATIDNTDYTVTCEKSYISPIPINVLGNATPEDCARHCTSETTCVAIIWDQGNCWQFDSAPTGPISATGAIAMKPGVKTVPPTCQDTLQQCEADKQQALSDKQASDLSLAECEKRYTDALGPHHNCAKDNEIVTASNGKRYSARCKRGTGTGSVVISPMKSYIARQGCIDDCSRTTSCTAVQYSAALRQCHRYSNIGINYGSNTHYDAYLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8H5</accession>
    <name>A0A5N6U8H5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_172070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8H5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="389" mass="44002" checksum="72F8F2874573F74F" modified="2020-04-22" version="1">MTSQSPEEGQDAYHLNGLHPVHLGDIFHCRYKVRRKLGYGLYSTVWLVEDQNCRCYRALKVLSAECYSGSNSLFELEVLKHLHDFHPEHPGCRYIPKLYESFEHVGPNGRHVRLVLEPMGETLASFGTLFENHQIPGPIIRRFTRQLLLALDHAHQSGVIHGDIQPRNIMIQIPDLAIINDYLRKTPADLAVAPTSGSHILPSQPLRDFYIPKSSDLGDLDVALCDWGSASWTNKHLTEVIQPVLLRAPEVIIKAPWDTPVDIWNLGAVLLEALDAVRMFSGRAAQTGGEYRTKHHLEEIVALFGPFPSWLLAQGEKEVVDVYFDENGRIRDPIPRPEALLENWIESLVGDEKAEFIAFLQKMMRVGPCDRLAPRQLLAEPWLQHGCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U975</accession>
    <name>A0A5N6U975_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U975"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="538" mass="58371" checksum="8B4917BE23FBF1D8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCX9</accession>
    <name>A0A5N6TCX9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_112241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742749">
        <property type="protein sequence ID" value="KAE8144152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCX9"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="225" mass="25117" checksum="0B9B213FB46EF047" modified="2020-04-22" version="1">MSQPRAIMYHYSMAANIHACPPMEPSYSTSSDDSSQSSMGFLEPYHMASNDLELYSQASNTSAYSSSYPSSSYSSFSSSSFDSASMDSPMEYAPPMICAPEMNPQYAPQYFSSPVQTSWPTAQMTPVEEYTFPPLETHYTPCESAKPVKPYACHCGRAFTRPADLKRHQSSVHNPVFQDCPVSGCIRKDSNGFPRRDHLIEHLRSYHHLDVPKRRAAAKRVAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDP6</accession>
    <name>A0A5N6TDP6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_92543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742504">
        <property type="protein sequence ID" value="KAE8144493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDP6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024966411" evidence="2">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="121" mass="14477" checksum="11B11ABF2796846F" modified="2020-04-22" version="1">MPISFPFLLFLANLTRLSCFQCNACAICPRFSGHNHVLIVYNAKNPFMLLVFTAHFGYALYLLVLWHDDPQSFFSFFPFCYCFIFYFFNFFFSPLLCQSFISWIGLWWRSQFIIRYTPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDS8</accession>
    <name>A0A5N6TDS8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_171689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742574">
        <property type="protein sequence ID" value="KAE8144309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDS8"/>
    <dbReference type="OrthoDB" id="2349272at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024934637" description="Transglycosylase SLT domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24013" checksum="AA300F658F41C918" modified="2020-04-22" version="1">MKLGHFWTALWLLWSLLANAAPMSHTACSIESRSNDITKEQILAIAPDSSSCDNAPFIKECATAEVAAKNIAKSFETYKITEPAEQAAVIALMAMESGQFKYNKNHYPGVAGQGTRNMQSPAFNLEYAKSIVELSKDLASVSSNPEGVLNILLKNEAWDFGSGAWFLVNKCTQEVRTQLKSGSEAGWKGYISTCVGTEANQSRKEYWTRAMQALKVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDU7</accession>
    <name>A0A5N6TDU7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_134647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="ML742512">
        <property type="protein sequence ID" value="KAE8144467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDU7"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="4" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-1207">Sterol metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="375" mass="40586" checksum="361C6E79BBAD8234" modified="2020-04-22" version="1">MGYQARHYGQSRWQCARTRKFKHILDDLQYITRDNDGSKVLIENFVGYTSVPLGLAGPLRIHDFNGASEDAYAPMATTEAALIASCCRGCKAFNMSGGVHYSVLGEAMSRGPVFQFDSPREAILFTRRLPDIKDSLATAAESTSRHVHLQDLASHIIESNVHVILKYTCGDAAGQNMVTFATQHACDWLQNSSLAAELNIKGFLIEGNMTSDKKPSWGSVKESRGVESVLGCTTEDFYKTYRAAQEGGIRNGQFGSNVNAANVITAIFIATGQDVASVAEGAWSLLTLDYDNASKTLKISIYLPSLPVGTVGGGTGYNTQKEALQIMKCAGPGMKPRFAGLIATFAMALEISTIASGANDTFSRSHQRLARQNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDW3</accession>
    <name>A0A5N6TDW3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_91720</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="ML742494">
        <property type="protein sequence ID" value="KAE8144522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDW3"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="17">
        <location>
            <begin position="231"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8144522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="456" mass="52061" checksum="B4D165351A2E2139" modified="2020-04-22" version="1">MYILEQLARLLDRPFFPWKNVLVGFSLGQFILENILSFRQYKVLQRTKPPQVLKDEVSQKVYDQSQSYGRAKAKFGFISGLYGQIQNLAFVYGDVLPKVWGLSGFLLAQYFPSWLQGEITQTLFFLFGFNIISLVLSLPVTYYNTFVLEEKFGFNKQTMKLWVTDMIKGQVLSIALGTPIISAVLKIIQKTGNSFFYYLWLFGIFIQVFAITIYPIAILPLFNKLSPLEPGVLKTSVESLAKKLNFPLQELHVIDGSKRSAHSNAYFFGLPWKKHIVIYDTLIEKSEPEEVVAVLSHELGHWSLSHTTKLFGIAQSHMFYIFALFSAFLNNQSLYHSFGFVNEQPIMVAFILFSDALAPMDAVVKLLMNILSRKFEFEADAFAVKQGYSKELASSLIKLQIQNLSTMEADWMYASYHYSHPILSERLKALGWKGGKVTDRKAEDSDKPVKAADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE83</accession>
    <name>A0A5N6TE83_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_166938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742538">
        <property type="protein sequence ID" value="KAE8144401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE83"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
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        <source>
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            <dbReference type="EMBL" id="KAE8144401.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TED4</accession>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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    </dbReference>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetes</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
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        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <ligand>
            <name>GTP</name>
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            <position position="31"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <feature type="binding site" evidence="3">
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            <position position="70"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
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        <source>
            <dbReference type="RuleBase" id="RU003925"/>
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        <source>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="182" mass="20188" checksum="247BF585884238B7" modified="2020-04-22" version="1">MGGSLSRLWSFLWTKKEIRILILGLDNAGKTTLLYRMKIGEVVTTIPTIGFNVESVTYRNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVIDSTDIERLGTAADELAAMLNEEELHDAALLVFANKQDQPGAKGAGEISEALRLGELRDRNWSIVACSAIDGKGLNEGMDWLVQTLQSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEM6</accession>
    <name>A0A5N6TEM6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_166128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ML742442">
        <property type="protein sequence ID" value="KAE8144756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEM6"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024864455" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="541" mass="60991" checksum="0EE1C12293A1D3D8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEM9</accession>
    <name>A0A5N6TEM9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_134387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742442">
        <property type="protein sequence ID" value="KAE8144757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEM9"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="8">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="7">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="162" mass="18461" checksum="EA0CA7B6A54AC7A0" modified="2020-04-22" version="1">MSSSNPTLVFMSSDGVEITVDRDVAERSLLIKNMLEDLGETGEAIPIPNVNEAVLKKVIEWCAHHKNDPASTGDDDDSRRKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKGLLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEN4</accession>
    <name>A0A5N6TEN4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bud-site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_145223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742427">
        <property type="protein sequence ID" value="KAE8144833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEN4"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="419" mass="45754" checksum="79B306131B0F6452" modified="2020-04-22" version="1">MPKRKLSDVDGPGPKRQSMQAIRLGNKFEQGVTQLSRAIKTARGFERQKLGRREKTAKAQGDSEALARLGEEITFLKGLDPSVIAQKYLFKQLVKTKRIAETSAFVEFQESRKIAADGPRSTAEANVLARLYKSTPVKNVFPNLMTEIRRLLKLDDVAGGDKKKAGKEGGSKDGATKVKSESRGERVAKQETVSDGEEEGVGEEMSDVDFGQFDARLAPDSEDEEEAGSGSDDASDGGVDLQAHSETSISRSPSPDSPPAKKQKAKSKTASAPATSTTFLPSLTMGGYWSGESEPEEVESAEPPRRKNRMGQQARRALWEKKFGSAANHVKQQMDRRGRDSGWDMRRGATDGTEGPYGRRGQGRGPAGRPHFDGDRPQRGPPRAKPEDNKPLHPSWEAAKKAKEQKATASFQGKKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF08</accession>
    <name>A0A5N6TF08_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742419">
        <property type="protein sequence ID" value="KAE8144887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF08"/>
    <dbReference type="OrthoDB" id="4490263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="187" mass="19930" checksum="D34C823977757C1B" modified="2020-04-22" version="1">MGPSLLISNESYKFITSTWAVDTKQQVHQFFTIVLCRPHKHFTLKASFILNVVNFRSVTVATAVLGVYATALPTGTTPGNEISASTLTGRCVPDDPTSCGTGSIKRDAPQRRCLPDDPTSCDPGDFGSTDSRRDVPQKRCIPDDPTSCGPADFGSTGSAKREAPQKRCIPDDPTSCDPSDFGSTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF39</accession>
    <name>A0A5N6TF39_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER lumen protein retaining receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_81129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742414">
        <property type="protein sequence ID" value="KAE8144917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF39"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="338" mass="39199" checksum="DF5D56459BC88D6F" modified="2020-04-22" version="1">MMGMNVFRILGDLAHISSKCILIWAIHRNKSAEGVSLLTQILYATVFVTRYLDLFRAAGWFSIYNVFFKLFYIISSFYIIFLMMNVYPRTRERERAWKLAMGSVAVSLVLAPILIPIFYGGYPHHWFTEIWWAFSIVLESVCVLPQLLLLRQTTVPTVIDSFYLLTLGSYRAFYILNWLVRGFGPEKSWDPIADIFGVIQTAFYIDFAWVYYTRQRVKLRNGGVVDSEDFSNSWLVNKVLNFRQRRSVDEEQNLRDDGAEDGREGDDARPTNNRWGARGISISADDTLNEHRHPKPDKASGSDDRLEGFLEDEEDNWEEHATQQAQHEHSTDVPIDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFA6</accession>
    <name>A0A5N6TFA6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_171123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742435">
        <property type="protein sequence ID" value="KAE8144791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFA6"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="39681" checksum="8572D8D59E2A582D" modified="2020-04-22" version="1">MAISDLLGRRVRALPDQDEEAYSDESAPEERSDGERSESGSDLDEIDHRSPSDEDSESNDFDESDGEEDGEDSEDDDGGEPDVQESLSSISFGALAKAQASLGSKGRRNVKSTKAAEESTSTSSPLDDIRAKIREAREQKRQESEKSKGSAKPTRSSKHAPMVQSSKYAVSRKRTVVEPPSVPKSRDPRFDPTVLGQSGHSNPEFANKAYSFLDDYRASELKELKEVLAKTKNVEEKEALKRAIRSKSDRLRAIENRKREDTILAEHKKREKQLIREGKKSNPYYMKKSDLKKEVLLKKYENMNSKERAKALERRRKKITSKERKEMPMERRVGGENQDDGNGRKRRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFR3</accession>
    <name>A0A5N6TFR3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_165723</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742411">
        <property type="protein sequence ID" value="KAE8144941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFR3"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="253"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="37976" checksum="EDD5E0785D0CEC7B" modified="2020-04-22" version="1">MSLNRHGESKNRDPALSETPQLSSSSSSVKEPPAEHMNNCLSDIKSKVAEPVIAAFIAGGVAGAVSRTIVSPLERLKILLQIQSVGREEYRLSIGKALVKIGKEEGWKGFMRGNGTNCIRIIPYSAVQFGSYNFYKRFAEPSPNADLSPIRRLICGGAAGITSVTITYPLDIVRTRLSIQSASFAALSQRNSSKKLPGMFGTMVLIYRNEGGIVALYRGIVPTVAGVAPYVGLNFMTYESVRNYLTPDGDTTPSSARKLLAGAISGAVAQTCTYPFDVLRRRFQINTMSGMGYQYTSIWDAVKIIVAEEGPRGLFKGIVPNLLKVAPSMASSWLSFELMRDFLVQLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG75</accession>
    <name>A0A5N6TG75_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_164791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742351">
        <property type="protein sequence ID" value="KAE8145384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG75"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025010573" evidence="3">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="41465" checksum="93D29C8D68578FA8" modified="2020-04-22" version="1">MPPSTFTPVISLALAGLISGVSAEGISLVSSTFTTPSPTPTAQVITFPLAGPDPTGDDDDTGECRLLGPFSLLVQVALGGLALLSLVYKRWKERPQRPVKVWAFDVSKQVFGSAMLHLANLLMSMFSAGQLEITSDYRPNPCSFYILNLGIDTTLGIPILIFILHILTRLALFTPLANPPESIKSGEYGRPPRATWWFKQSIIYFIGLLGMKICVFFLIQLLPFIVKIGDWALRWTEGNTAVQIIFVMLLFPVIMNGIQYYIIDIFIKKPSHELLEEGEGEDALDNGDDHHHALLAGLDEEGASDSEDDTVGKDVGRGLEASPHKDALGVFESSVYHPHFEPDLISASSASACSRNDHDNEDRAPLSTKLTTRRMDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGN2</accession>
    <name>A0A5N6TGN2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_164521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742339">
        <property type="protein sequence ID" value="KAE8145503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGN2"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="440" mass="48305" checksum="A4064505A0932F4A" modified="2020-04-22" version="1">MTLPPKILIVGGGVFGLSTALSLSRRHPNSQITVLEASPTIPNPHGSSVDASRIVRADYSHPLYAKLANEAIELWRNTEWGAQEDRFVQNGLLLVYPDGNTNGKEYAAKSYDNVKVMEGNNVELLTSKEEVLRVAPAYGEELNVAGGYVNWGSGWSDAEAGVRYAKKLLDQEGKVVFQHGDVQSLIYADQVTDDSQRKVTGVRLADGTSVTADLVVLATGAWTAKLVDLRGRAISTGQTVAFLRISDEEQRRLEHMPTILNFATGFFIIPPRKNLLKIARHAYGYINPKQVPVPMAEGPSMEVSLPEPGAPVPLEGEEAFRSALRQLLPSLADRPFVQTRICWYTDTPEGHFIITYHPDHPNLFLATGGSGHGYKFLPVLGDKIVDALEGKLEPELRDIWQWPAAVEGEFEGDGSRSGEKGLRLMDELAKTKKAQRKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THH1</accession>
    <name>A0A5N6THH1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein endonuclease SAE2/CtIP C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_164021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742319">
        <property type="protein sequence ID" value="KAE8145710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THH1"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="570"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="716" mass="80059" checksum="C8797F4D2B1ACC55" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THJ5</accession>
    <name>A0A5N6THJ5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_163795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742311">
        <property type="protein sequence ID" value="KAE8145806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THJ5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="97" mass="10834" checksum="C1097029DFB7961E" modified="2020-04-22" version="1">MERQSFESSFRLTCRILSWPFFSPASHFLSFTHSLIQTAIPCWFRGEAFCRSMVLIVSSGVREGEAGIKRGRWKRWGTGDLSGFGLINVGGCVIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THN3</accession>
    <name>A0A5N6THN3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_61085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">IBT 18842</strain>
        </source>
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</entry>
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                <person name="Nybo J.L."/>
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                <person name="Lyhne E.K."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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    </evidence>
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    <name>A0A5N6TI51_ASPAV</name>
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        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="7" type="ORF">BDV25DRAFT_144348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="ML742314">
        <property type="protein sequence ID" value="KAE8145779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI51"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF5">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="153" mass="16457" checksum="4DA3661EF2514BBD" modified="2020-04-22" version="1">MGKAILLINGPNLNLLGTREPHIYGATTLADVEASSKAHAASLGATLDAFQSNHEGAIIDRIQAARNNIDGIIINPGAYTHTSVAIRDALLGVNIPFIELHVSNVHAREPFRHHSYFSDKAAGIIVGLGVYGYRVAVEHVALNFKSREERAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI53</accession>
    <name>A0A5N6TI53_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742292">
        <property type="protein sequence ID" value="KAE8146025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI53"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="345" mass="37313" checksum="2EC9CFF29FA7F94E" modified="2020-04-22" version="1">MRAIQVKEYVKGPLELQITSLPTPSPSPNEYLIEIHSAGTNFFDLLQIQGKYQHQPPLPWIGGAEFAGTVLALPTSIPASRACFRIGDRVFGATQGAYATHILAPEHTLLPVPNGWSFEDAAGLFVTAPTSYGGLVHRANVKPNDWVLVHAAAGGVGLAAVQIAKGKGAVVIATASTERKRQVAREFGADYVIDYRNKSWPEEVKSLCAQHRTGNGKAGVDIVYDPVGMIDASLKCVTWNARLLVIGFAAGNIEKVALNRVLLKNVAVIGLHWGQYAKFEKDTVSTVWKGVFDLVAQGKFKGTAFKDESFVGLESVPMALEALGRRETWGKVIVKVINDEPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ34</accession>
    <name>A0A5N6TJ34_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ34"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="159"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="257" mass="28669" checksum="22841432546E18BD" modified="2020-04-22" version="1">MSTTTTALTSTTLVGMLPTMTSTTGLLPGKNCPTCGQEPLLSQEHGADRKKAKELEGQVDFLNVQATQMAEKLAEYEAEVRRLRTQNYPYTPRNGSSVSSRSSHESSRPLSPPQAISPRSQPQSQGRLSTLTSFLHSRRPSNTSPSQTPPQTAARAPSRQSSPDNTAELQTALNREQSLRKEAESQLSQANSELEELTAQLFSQANEMVAQERKARARLEERVAVLERRDVEKRNRLERLEKAMERVERIRALVRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKD7</accession>
    <name>A0A5N6TKD7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_169557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742241">
        <property type="protein sequence ID" value="KAE8146812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKD7"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="744" mass="83032" checksum="229846815FC54EEE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKJ9</accession>
    <name>A0A5N6TKJ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742250">
        <property type="protein sequence ID" value="KAE8146639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKJ9"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024972267" evidence="3">
        <location>
            <begin position="18"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="471" mass="49859" checksum="360F40F8F5A4B75F" modified="2020-04-22" version="1">MWSTTLLALATLDLTAAERVLGAYIFARHGDRTPKVLGNTRLTDLGYSEVHQAGTYYHKRYIADNSSSQIEGISPAIVNLTQLTASSPSDAVLQNSGTAFLQGVYPPAGASATETLSDGRKVQAPLQGYQLVPLSLISSNANSEDNTWLQDATGCNNAKVSSNSYYSSGLYDEVLAQSGGFYRSLEGLLNSTFAEGKMSFKNAYTIFDYLNVASIHNSSNTPTSAQLTRLYQLANIEQYNLAYNDTDTVRAIAGAQLAGEMLQGLNKTITSKGKTKLAIQFGSYGTFLSYFGLAQLPSTNVNFTGIPDYASSMAWELVTNSSAPFPDEEDISVRFIFHNGTIPASGAPATFPLYGQSAPSMSWKTFVAETRKIAVTSTPEWCKMCGNTDGKCASYSAGESGSEASAASKGEGGVSRPVAGVIGAMVTLAVILGLQALFFLVGGFRITKKGKGTVPVGGVTEDKSKGQSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLH3</accession>
    <name>A0A5N6TLH3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742219">
        <property type="protein sequence ID" value="KAE8147206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLH3"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="195" mass="21491" checksum="60088084FB047E3E" modified="2020-04-22" version="1">MSTFAFANSSEKVPGNGALPAEFTIKASAGTDIWSKPPSTEQFNAPILYKSIPLKSFKRARVAFNALWKAKYDQGGLILVLNGAGGVRKWVKTGIELTNNKPHLSTVTKDRFADWSLQPVPSGGGAATLEIVKEPDNSLWIYLVEGVQKNPLREITWFFEEQDVQDLWVGLYAAKPSKEGQDLVVNFGHLIIDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLS1</accession>
    <name>A0A5N6TLS1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_160637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742214">
        <property type="protein sequence ID" value="KAE8147297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLS1"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="367" mass="39817" checksum="FCEFCC6957E1E443" modified="2020-04-22" version="1">MSNNPHDFSDPNRQGQYPPPQWNTSQPEDNPSAHYPPASQYPYAPASYPPPADHQYPPPHSQYPPPPNMAAIHPHVQGPQDPYRLPPPPPGAYRPPDVYAQQPPPPQVVYQAAAPRQRTAIACRYCRRRKIRCSGFESSQDGRCSNCIRFNQECMFTPVSSQAQAFVPAHAAYPHLRNAQQGRGGAPVMLYGAHGQPLPPQQQPQPDTTLPPPQGMYQPTYGGAPPPLSSVPQDPRPIGRRGSGSGFEYPDPTNLAPVTPATSASGYQTHPAAGSYYPPPPQHDRRPSPQSAYPYDNRHSSSPHNSPYPPLHASQSAMTPPPTSTPGGTSRGGLNVRDMLNPGGDSQGRSSTDSDMLNALNRRGLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM30</accession>
    <name>A0A5N6TM30_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM30"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39557" checksum="B4D56B8C95B06AA8" modified="2020-04-22" version="1">MALDLVVQFISFQLLHSFSFLISSNTLDNAVTMVWRYLSGADDGYLPGGIAIIDLVSIAISSLIDYYFSHVVATMLILESERLHAMGQSTTEFVRNIHEPPTTRSVTRTTAFLYSSGGPQMLLRGMKAGITYYTALYTLTFIIHNVFLRHQSLRPIARLIATALLTELHMTWTHSIISTTSPTASVSKLRHNRRIWTRLLVPSLVCASAQTIIDYLPEAVSHSYDKLFSHIDPDSLPLHFLAYYDTFTILPALILRMGVVLPASIALTLVEANFLPESETTIVPAAKDRRARMSALVWGKISKVRSGFGGVYGLVRRSTYFWLWELHLKRGFLRTACDLLALTLGSMLLDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMD8</accession>
    <name>A0A5N6TMD8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMD8"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="487"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="548" mass="62297" checksum="E0E045C6AA8B47B7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMG9</accession>
    <name>A0A5N6TMG9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric reductase NAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_32784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742205">
        <property type="protein sequence ID" value="KAE8147490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMG9"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="238"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="63125" checksum="C01A89CBE0B435E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMJ0</accession>
    <name>A0A5N6TMJ0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_160239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742204">
        <property type="protein sequence ID" value="KAE8147510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1767"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1797"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1871"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1883"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1917"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1927"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2028"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2039" mass="230896" checksum="7FE8D1067C9D4E07" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMN7</accession>
    <name>A0A5N6TMN7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_131963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742201">
        <property type="protein sequence ID" value="KAE8147560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMN7"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="581" mass="65170" checksum="63B9600F3355CFA8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNL5</accession>
    <name>A0A5N6TNL5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_142289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNL5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27649" checksum="6191C48C36405849" modified="2020-04-22" version="1">MISDFSGVSLKGKTAIVTGASRGLGAGIAILLAKRGANVVVNYVSDSSAKRAQEVVDQINNQIGTKAILCRADVSKLEEIPTLVDAALKISETGKIEILIHNAAQGLEANLVDTTPEFYETHFNCNVRGPIFLTKAVVPHIAKGGRIVFISSAGARLGVAGQTVYAATKAADEALVRVWAKELGQSHNITVNCVNPGPIATDQWFQSDEQFLKDMQPLIESTPAAARVGEVDDVAPLVAFLCSDDARWTTGACLSANGGLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNM3</accession>
    <name>A0A5N6TNM3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_25676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNM3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="123" mass="13847" checksum="3A4101F9A40625AB" modified="2020-04-22" version="1">MIQGDSISFIGYICRGGSVYDSFGAVYAGCEMLLPATKTQATIIDYAVILYAPWDGLRNLPREMISTQCYIPSQCGTHCWIWVYAIFGKFFCSFCYLFIMFSLVLHFSKARGVLAEREACSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNP9</accession>
    <name>A0A5N6TNP9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742181">
        <property type="protein sequence ID" value="KAE8147992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNP9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="60" mass="6570" checksum="9AD3E203AB71C71A" modified="2020-04-22" version="1">MSPRDLDNPRLWTTRMRGNGRRLNFRLQNGLGLVNVWGLASGVAAALILIPPAEGCLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNZ4</accession>
    <name>A0A5N6TNZ4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_22981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNZ4"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="687" mass="75464" checksum="CECC9DC512C6C8D9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP32</accession>
    <name>A0A5N6TP32_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_159011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="ML742175">
        <property type="protein sequence ID" value="KAE8148113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP32"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025056234" description="chitinase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="16"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="375" mass="41478" checksum="EF995040F7D0300C" modified="2020-04-22" version="1">MKLLQILSVVNAVAGFHFIGYVDEWHSKTLPEASSASALSHLVVAFAKSTFFNEPELNKTKPFTTSQELRSKYPSSKIMIAIGGWGDTNGLSDGAKDEASRKQYAKNVAAYVDHFGFDGVDIDWEYPGGNGDDYKKIPNEQKKGEIETYPLLLQAVREALPKDKVLSIAVPGRKPDMIAYTKEQSGKIWESVDHVNIMSYDLMNRRDAVTAHHSSVQGSLEVVKRYKELGLDGKKINLGFAFYAKFFETQPNCTEAKPLGCPVAVLEDPATGADTERSGAVTFEKEPFAKPEVLKSWETAKGAAKADDVAGGQYAYDPATHYFWTWDTPTFMERKFKDIVDAEGLGGVFVWSLGEDSAAWDHLKVLNDGAAKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPY2</accession>
    <name>A0A5N6TPY2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPY2"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="12"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="397" mass="44745" checksum="ACE7F00A2D70A9DC" modified="2020-04-22" version="1">MGSISSSKANHALVFGASGINGWAFVNALANNYPDPGAFEYITAFTNRPLSAEQAQWPNSDKLRLVCGLDLKEASQETLEQELVNRVPNLESVTTVYFCAYIPDLNSEREIELNIGMLRRTLVAIEKLCPEFQFVVVPTGVKAYGVHLLGNFPFSDNLPLKETHPPIEEPHLSQLFYTHQYELLKTMSKGKNWTYCDVRPDIIIGFVPNNSAHNLAQWVALYLSLYRRIHGEGAEVVFPGTKSWTIQSNDSSHDSIARFAIHASLHPEVSAEQSFNVADSATPTSWSVKWPILCQYFGLKGVAPTNGPGPDLTTFLREHQDEWLAMEKEYGLQSGHLVGDDLSIPYVPYFLISQFDFDRQLDLTKMHKAWGDAKEERDVQGAWYTAFDRFRKARIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQH7</accession>
    <name>A0A5N6TQH7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_157955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742153">
        <property type="protein sequence ID" value="KAE8148612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQH7"/>
    <dbReference type="OrthoDB" id="5332384at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="236" mass="26184" checksum="F12154DEB28EEABE" modified="2020-04-22" version="1">MSYELVQTAALSLNTYPWHFILTQKVQRPLRKSMNIYIFLEAPQSSSGTIRNTQPIMALSLVLILLWVGTASTLVARQSCHVQVAIRTFYGYPDNDPPGAGIAYDCGRGQIAGGTGTFNDPLTFATAPGEFETCEIIYDPYLRKYLRMEDYCESCNREWGNRVWHIDVWTGSNTVNGGNSQVDCEVKLTPTPQDKPIVRRPGANLAVDTTPLYVMLNTPVCNVGSVFPSYVAQSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQJ1</accession>
    <name>A0A5N6TQJ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_16627</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742156">
        <property type="protein sequence ID" value="KAE8148544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQJ1"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000079">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
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        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="563"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="12">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8148544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="618" mass="68847" checksum="CD0DDB51FD5ECD2A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQK2</accession>
    <name>A0A5N6TQK2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
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        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_141592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
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    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
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        <property type="protein sequence ID" value="KAE8148633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4422381at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004555">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="723" mass="82378" checksum="8D33E23C332A622C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQQ3</accession>
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        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_13496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="ML742150">
        <property type="protein sequence ID" value="KAE8148683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQQ3"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
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    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
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    <dbReference type="Pfam" id="PF02780">
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    </dbReference>
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        <property type="entry name" value="Transket_pyr"/>
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    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
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    </dbReference>
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        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="41801" checksum="7B18B995155F7669" modified="2020-04-22" version="1">MSSLRLPRLIRPARRFYSGAATPSSRLNIPIDYKTTPLLHHTSSSLSESLDLPGSTTSKPLNLYQAINSALRTALAKSDKVMLFGEDVAFGGVFRCSMDLQTEFGSERVFNTPLTEQGIVGFAIGAAAEGMKPVAEIQFADYVFPAFDQIVNEAAKFRYREGATGVHAGGMVVRMPCGAVGHGALYHSQSPEALFAHVPGVQVVVPRSPSQAKGLLLASIFEHNNPVIFMEPKVLYRAAVEHVPNEYYTIPLSKAEVLKPGSDVTLVSYGQPLYLCSAAIAAAEKALGVSVELIDLRTIYPWDRQTVLDSVKKTGRAIVVHESMINYGVGAEVAATIQDQAFLRLEAPVKRVAGWSTHTGLQYEKFILPDVARIYDAIKQSIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQZ5</accession>
    <name>A0A5N6TQZ5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_16109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQZ5"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="268"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="616" mass="67466" checksum="42E5364DE69F49DC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRZ3</accession>
    <name>A0A5N6TRZ3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_141124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742134">
        <property type="protein sequence ID" value="KAE8149123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRZ3"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="51739" checksum="F94FB92F67E5DC38" modified="2020-04-22" version="1">MAAVGVSQASSPRLPSPPPFTEVQIGPKSPSVGESFGKDAEQFLGTTQQADEGSTRRIRPGTKSVDMAVGPPLVPLSQLDSPFQLQEHLKALYNYYTRPEGSDTVIPISREVAIQLAEPPEGVDRSLWLYELCRFLTMKVNNLIIAFFAESPPCSATTCPEMRASEWQYLCAVHDPPKSCCAIDYSCHTLDWATNILTSPKYFPSRLTLGSEAGGGPQASMRHLTNIFRRLYRIFAHAWFQHQQVFWQVEGYDGLYIFFKTVCDFYHLIPEDNYTVPAEAEGVEPRQQPQEQPDVRRMTILRKDSEDSVVTAMEEPPSATTRRHKNNPSISSRPVTTISESVEDEEHHPKQEVVQVVDATTQESEPQPSTEAASEQPKESSEQPSIDSSGSQVTVAEVHDDEETPMTEAEDATGDVTEGDSEPNKGAENPPESEPEAVTIEVTEPKPDEPKQTTDQEAEAGTESAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSS6</accession>
    <name>A0A5N6TSS6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-glucanase/mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSS6"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024837846" evidence="1">
        <location>
            <begin position="20"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="501" mass="54620" checksum="69A553AFA1D0697B" modified="2020-04-22" version="1">MLFKFILLALLGTLSLSAATPLPQEGPDKGASDRLVFCHFMIGITSNRKGAADYDDDMKLAKGLGIDAFALNIGVDPYTDTQLGYAYESAAKNDMKVFLSFDFNWYNTGQASAVGAKVKQYASLPAQLKVDNKVFVSSFAGDGLDLPAMQSAAGNEVFFAPNFHPGQGDFNAIQGALNWMAWDNNGENKAPTPGRNVSVADGDKAYVDALKGKPYVAPASGWFFTHFGSEVSYSKNWVFPSDLLWYNRWQQILGLSPRFVEIVTWNDYGESHYIGPLSSPHTDDGASKWVMDMPHTGWLEMSKPFIAAYKAGDKSVDKYITDEKLIYWYRPTPRDVNCDSTDTTMQGSPNNASGNFFTGKPNGWETMQDAVFVVALLKSPATITVASGKVSEKFEAQAGASAFTVQMGVGQQKFAVTRDGKTVMEDTSLKDIVDTCICGIYNFNPYVGTVPPEKTIDKLQSDGLAMLTQGLKVPCATNTLGGSRSPAPRSNDTWLFMYTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSY1</accession>
    <name>A0A5N6TSY1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative FMN binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_130353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSY1"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="412" mass="45130" checksum="7416D91B041B56FF" modified="2020-04-22" version="1">MSFSLSDAVKLPCGLVFPNRIVKAAMAEMLAGFGHNPTPSLVEVYNQWGQGSWGGLLTGNVQVDVNHIGSPFDPALHGEYKGKESCETLVENWSNYARACQQHGTPAIVQISHPGRQSFRGTGKRGFFASTIAPSAIPVQMGTSFIEWLMGCIAFPAPREMTQADIDTVTRQFIDTARLMADSGFSGIELHGAHGYLIDQFLNPKTNIRTDAYGGSPEKRAKFVLDIIRGIREVVPVNFCIGIKLNSADHSLSTFDDTMTQIRLLIEAKIDFLEVSGGSYEDPKPQKSARTAAREAFFLEFARETRKRFPNLVLMLTGGFRSRMGAEFALKENACDLIGIGRPATIDPKFPRMLLDESIPDEQAQLLLNKVPAPFFTRIFPSHIIGAGLETTYYGGQIGRISKGLKTVAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT33</accession>
    <name>A0A5N6TT33_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_156134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT33"/>
    <dbReference type="OrthoDB" id="5100247at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="141" mass="15859" checksum="226A95CDE3FA857C" modified="2020-04-22" version="1">MSLSISETSPVEQLFLDLPIQEVLHPRRGQTFIEPWTHMYVDAIRDTRLGDAVWARYHIYGDVDNGIVGGSNNMTVLDVIKEDALSYRVNAPEEYFEALSIYSKTSGADGHLDVLKVITNLDEREIAEFKAREEAEGADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT60</accession>
    <name>A0A5N6TT60_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT60"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024871913" description="WAP domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23316" checksum="A05E6DD77622FF22" modified="2020-04-22" version="1">MKAYFLLLLFAILVASSVEARDTTLEARRYKTCVKASDCGESGWACCQGRCQRMDGEFTIASCQFVADAPQPSDVTKRDTTESPEISPKSSCQTSSDCGGDQWYCCRKRCYARVNGETPPCARVGELGLEDLDIDFPLNEEEVELARRGEIGDPTPQAEGADSADKPKPCEHWWNCGVNGEHQWACCNKKCLKWYPGSTPWIRPKCLPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU74</accession>
    <name>A0A5N6TU74_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec39 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_124368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742117">
        <property type="protein sequence ID" value="KAE8149631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU74"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024871546" evidence="6">
        <location>
            <begin position="23"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="7">
        <location>
            <begin position="13"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="924" mass="102481" checksum="55F91EAA66B2AEEB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUM5</accession>
    <name>A0A5N6TUM5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8149781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="210"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="425"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="598" mass="64155" checksum="CFF3D2A7B0755071" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUW6</accession>
    <name>A0A5N6TUW6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNARE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_140078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUW6"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000018">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="177"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="271" mass="30739" checksum="091D57466E6287F0" modified="2020-04-22" version="1">MSFDRLSSLESQPTTFRRSDDPQYQDDPDFHRLTESLSNQLFSLTSNITRLSDQIALLGTRRDTERVRERVHNLLEQTRAGFKEVGEGIKKVQTWEDVNPSQKWTQQKLSSEFRATLDEFQTVQRRALEKQRASAVAARTAVEDGEQPAPKGAAQGQQQLLDEQPRLANQDEVDFQESLIIERETEIRNIEQSVGELNELFRDVAHIVHEQGGQLDIISENVERVTDDTRGANVELRSASRYQKNARNKACCLLVILAVILTIIVLAAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUX5</accession>
    <name>A0A5N6TUX5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUX5"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="552" mass="62016" checksum="68737C0F6CB2C278" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV59</accession>
    <name>A0A5N6TV59_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted antimicrobial peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4444487at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015201">
        <property type="entry name" value="Antimicrobial_MiAMP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09117">
        <property type="entry name" value="MiAMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024957941" description="Secreted antimicrobial peptide" evidence="1">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10598" checksum="A03C22CE4471F2CF" modified="2020-04-22" version="1">MKLLTITTLLTAATATIVYPYTSASCGGSTVGKISACGCTNMGANYKIRGAKLNFQKATASFYKEKNCKGAFISKASDQSCLKPVVGWETFGSVRIHGGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVI8</accession>
    <name>A0A5N6TVI8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_172207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVI8"/>
    <dbReference type="OrthoDB" id="4653208at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30579" checksum="258D4821488106CF" modified="2020-04-22" version="1">MDNYDTRTLHPREVLRQVADSTNGQRNGLSVTLPVHTTWRAAIRAAEAALGDIDEPMLLMPRGTGNRLGLPIRTTIDLKTVEPRPPLSTAARERLRKMAEEAANTEFRDPYVSLRPKLGESFLPIVRADLVLRGLDSNDSDPLCKLEGVDMVFDTGSHRTIIVEDLLSASFQEYLKGSVHDPYRSSDGSVLQVSVTMAFTNCPVVIENVAVIIPKAKMPNERVGVLFGQLSCIDRLGLRSIPRRMLLAKGVVVSDEFWGDIVAEEYLNLNDEIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVQ8</accession>
    <name>A0A5N6TVQ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_129520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8150462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="5-keto-4-deoxy-D-glucarate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
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        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
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    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="266" mass="28313" checksum="75B493CD2066ABCF" modified="2020-04-22" version="1">MIYPSAITSTLHNPALRLLNALRANTKPIMTFLGLPSFRTAQIVAQTGVDGIIIDCEHGNISDDSMHGSTAAIAALGVSSLVRIRGTHSDLIKRALDAGAHGIVVPRINTAEEARTIVSYAKFPPQGLRGQGSAFPGLARGVDIPTYIKTANETLLTCVQIESKAGVENVDEICAVPGVDMVFIGPNDLALSVLGYVPAKGTEPEFVGAVEKIVAAARRHGKWVGRLSNDGAACKEHLKVFDTVALSYDIRAIQNWYFAELRAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVT8</accession>
    <name>A0A5N6TVT8_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_154908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="642"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1115"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1129"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133558" checksum="7FD9823789E465F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW97</accession>
    <name>A0A5N6TW97_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW97"/>
    <dbReference type="OrthoDB" id="10385167at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18265" checksum="AE13D892A256C8D9" modified="2020-04-22" version="1">MASSTLAAVHNGSELYQSFIDKSGNLSILKGNPVVDKNFSGPHNIEIDERRIRPDPGTQISAVSLSRYSRPNDVEVRVYYMKEGYLEEIIWYSGGAPEFGWKKGNLGDHFRPIPGSGIDARYVESRKTVYLHYKEKDGDAGYRCAYEKDGGVWELRWLTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWR4</accession>
    <name>A0A5N6TWR4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_110305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWR4"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="454" mass="52161" checksum="17E11699E52B8CBF" modified="2020-04-22" version="1">MSLNSNLIAEKMYHPPTVQEIKEEELSIPHMGTSALQNLKSSLLQLPTELLYQILSHLSAQDLVRASVTCRCLAEHTNNDLLWANVVNSYLPDKIYDPGPFDSFRSLYIAYHPCWFIPQKKLWFSDTEHTGNLILARYDNRRGVIEAYRVIAERRTHQFQIWEWNPDVIIQTFHPKPSLWLDDPVLLLKNHYGERQYLRGDIRMPLSLELQQIFNSLSLCSTDDRPDPDLGKQWPPEIIPSQHRVSRNPDAHGLDLERLPRRFETISQDAFRIRRSAHFRLGMPVFTAGHSETLSTFATLDPALYTPTKEKPYQGIWVGDYSAHGCEFMLFLQGHGRSDSLFDDHEVNNDGVHQQGSLNAIKLTGDPNVPRGEVTFVSHDIGPRGLVRVADEKLFRGARIVRSEGHVAGLGFRDDTFIESQLILISTDCIAHYWEAMGHISYFRRLDIDELLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX43</accession>
    <name>A0A5N6TX43_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_129136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX43"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="15"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="382" mass="43969" checksum="2D923038C32F3568" modified="2020-04-22" version="1">MSDIFGYRPSTSKVALVAGANGISGGAIIDHLVKQPYGEWSEIIITSRRPNKSVHTDPRVRFVALDFLAPAEAIVEKIKELCKDVTHAFFTSYVHNNDFEKLHEKNGPLFRNFLEAVDLACPKLQRVVLQTGGKHYAFSFRDTNTPFVEDMPRYEGPENIFYYEQEDDMFAIQKRRGAWSYNIIRPMGIIGFSWQYLGINEALPVAQYFLICRELGEPPRWPGNLNSYHRVENQSFAPSIADLTVWAATQDHCKDEAFNHVNGDVIVWKFLWHLLAKYFKTPMDHFEAPTEETQPMDMAEWARDKKPVWESIVAKFGGDAETFQLDAFELMNWYITPALKNEPFMSTVTKARQFGWVRSDDTYQAWLQTMRAYENAGVLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX44</accession>
    <name>A0A5N6TX44_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_129296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX44"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="180"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="392" mass="42420" checksum="8F5D976C019AF8D8" modified="2020-04-22" version="1">MPQLTEPANLPPVPYNSTTIFNNTTIRQTIQITHPSDTLRLRLSNAFGVEDLSITKVAISLPVEQKLGVSAIQPNTTTEVFFSGKSETVVPTGGLVVSDPVRFPINAQTVISIDAYLRRGQGGGAVTSHPGSRTTSWMSFGDRVGAKNFTDPSVDSVDHWYYISAVEALLTHTSASCAIIGDSITDGRGSDTNRNNRWPDLLSKKMQETPTTPTITLLNQAAGGNRVLADGLGPNVISRLDRDILAQSGVQYAIVFEGVNDIGTADTDPKTQQDIGDRLITAYQQIVTRLHAASLPVFGATITPFGAPGNASDAQPYSDPEREKTRQRVNRWIRTSGVYDAVLDFDRVLRDPEIPTQLAERYDSGDYLHPNVAGYQALADYFPLEVFGGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXD5</accession>
    <name>A0A5N6TXD5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_107099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXD5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="569" mass="64535" checksum="2A4A0512056918E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXI2</accession>
    <name>A0A5N6TXI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXI2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="183" mass="20536" checksum="25A6AF4D413FBDBD" modified="2020-04-22" version="1">MDPLLLCGNRSISKLSMDDRSFDEKEIVGPSLYGPQYGISRVTRDNEGRQPGAQARKRTVVAGENSLSIGQVDLSPPTKHHTRVRSPDTLPISDQSMIMTNRCSFMNSPPPFHAENSSGQKTIPIPPLFHPLKTRYPPPILESPLFRRSNLSNQYYVPGVWPRIFSAPHNQVEFITQARLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXS6</accession>
    <name>A0A5N6TXS6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyacyl dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXS6"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="25848" checksum="4D43CAF425EBFE27" modified="2020-04-22" version="1">MATYTVVGSSRGLGLAIVKELLARDPAEVGLVVAAARSPTQALDEVVKQSAGRAVFVPLDVVSESSAAECVEKISSLQIGSIDVLINCAGVHSWLQGGVALMNDLEYQLKVNVVGAHNVTRALLPLLQKGKSKKIANISSAYGSMTAAESSAFAPCPAYKISKASLNALTVQYALSYKEEGFVFMAVSPGWLKTEMGGEDAHLTVEEGAQAVLRVVDDADSSSNGCFKNIEVPGWDNYDGKNIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY69</accession>
    <name>A0A5N6TY69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinol-cytochrome-c reductase complex subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY69"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="112" mass="12415" checksum="C4C0084BE30EA40F" modified="2020-04-22" version="1">MFSQTLRRAAAQTAGAYRSPFAPKYTTPLNWHGLTVGAATKYAQIAGTFGVSAGVFALFFFGEVPRVRNDILRQLPFFDEYFDRTIAPEDNVCIRALDARIIDYSGAMLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY77</accession>
    <name>A0A5N6TY77_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_153083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY77"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="127" mass="14709" checksum="9894F3285C71C70E" modified="2020-04-22" version="1">MLARLYTATLNVSDRCYHTTVCTLTFRSQTYCTSRRLKQFCILHRPVFVSHLFVPFFLHWGVLPFRIDSQSPWKSTREDYCKSVHLSGNHGAGHLPWSMSRTRALALANLRYGNASNYTHVLFSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY82</accession>
    <name>A0A5N6TY82_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_101688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY82"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8151031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="368" mass="42263" checksum="EFDA7CF90C758792" modified="2020-04-22" version="1">MYGNGQPSQPLPAMATPPSDSYPSQSVTSSRSRNNSDAMDIYVITDRHPSGREPAGYNHWNRNSPSVNSLYNKSADQPYYEENGRMYHAFRKGVYMLPCDEQEQDRLDIFHKLFTEARVGDGLIYAPHPTNGRFLDLGCGTGIWAIDVANKFPDSYVVGVDLAPIQPSNHPRNCEFYAPFDFESPWALGEDSWDFVHLQMGCGSVMGWTNLYRRIHAHLRPGAWFEQVEIDFEPRCDDRPLEGLAVRQWYHLLKQATQDAMRPISHNARDTIKDLQEAGFTEIDHQMVGLPLNPWHIDNHERKVARWYNLAISESIENLSLAPFSRVFGWDLDRIRHIASEVKSEAFNKEIHTYNILHIYQARKPTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYB3</accession>
    <name>A0A5N6TYB3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYB3"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34312" checksum="ADA7645319B096E9" modified="2020-04-22" version="1">MAHNILFTGASGYLGGTGHQVKQYGAEPLVANLNDAEDIHARIVDLNITIVFFLVDAYTAKHQPSLIQALGQVKAKTGRDVHFLNTTGAKQFSWHAGMPTDAPLLDTNPDLYDLQRNAKSPRDFVDDPVKANGVVIDNAERHGVRSYIFALCLVYDRGEGFGNKTSIQDVSIVQAAQGARQVCAVDAGDPTWPVCHVVDTATLYLQILRKILAGEEIGYGNGYYLASSGPIAWRKVYSAFAKALFKRGVVRDDQPKQVQVLLGGKCLFTAEHGYQIGWKPEYSPEHMLEVADEEVEQILEGLQENKDKANIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ25</accession>
    <name>A0A5N6TZ25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_89460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ25"/>
    <dbReference type="OrthoDB" id="10348156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="83" mass="9151" checksum="DF54F0795752B4C8" modified="2020-04-22" version="1">MCELLCRRYDGRGGCGHTVSYDYQRCNAALQRPDGRPCVPPSGRMRDLERVVDAQDDHMDGSCPICKGETPPSSEGSEFMLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ58</accession>
    <name>A0A5N6TZ58_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ58"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="52081" checksum="CAB982405B321A97" modified="2020-04-22" version="1">MANNPRKRWFQLNWFAPEDTKSERRLILKLDLLIVPYAFLAYWTKYIDQSNINNAYVSGLKGDLNLHGNELVHLQTMYTVGAVVGQLPFAYLFTRFPMSWLIPFLDIMWGVFTLLQYRVGSYGELMAYRFLVGWFEAAFFPGMHYIFGAWYRGDEISRRGGLFYVGLTLGTLTSSLIQAGTSARLDGVHGLAGWRWMYIICAIITIPIGILGHFVLPGTPDKPNKLVLTDADLTTSRARLARSGHKDDPFTLQTCTSLLKSKTFWALLALDILFWNASVNTTTGGYLLWLKSLSRYSTSRVNELAAISPALGIFYTLFICFASDLFLGPAWAITLAHIWNIIGLIILIAWNVPESALWFGFLTTYSAVAMSSVLYGWINSLLRYSSSQRAVTLVVVNAVAQSTTAWTPLLVFKTVEAPRFTKGYAFVLACAVCLVVGAHLVASLLRERDEKSVTGTDTVTVQSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZC5</accession>
    <name>A0A5N6TZC5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZC5"/>
    <dbReference type="OrthoDB" id="2896980at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="236" mass="26701" checksum="EFD8ABF3B85C3FC0" modified="2020-04-22" version="1">MPSSIIRSFDEKLPRSPHVMFTFKDNYREFRSSVSSTVAANAVRVYIKEDISSLQGFAARYLDLRLRPFSPLSEIMPALERSHVLSTEADVVRLSTLQLLHPVNIALQEFAPSGTVVVCSSEKQGGQNSRFDIQWSLRSEDGRFLTTLAILEVKNTHVVHKTDFTPAERTSETYEAGMQEAMKFAPQYTLLEGNAVWLSKQASKYSGICTDVAVFDWNAMFIFNFNGRDSTGRKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZQ2</accession>
    <name>A0A5N6TZQ2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_90588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZQ2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="432"/>
        </location>
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            <end position="470"/>
        </location>
    </feature>
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            <begin position="63"/>
            <end position="504"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="555" mass="62049" checksum="C0F4612CC4B952EA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZS7</accession>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BDV25DRAFT_152103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        </location>
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            <begin position="103"/>
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        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS00463"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="817" mass="91023" checksum="6DCE7895C9E90F46" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_171389</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
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                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28811" checksum="2A93A687F99EBD8A" modified="2020-04-22" version="1">MLRLDGKVVLITGLGQTTDEGWGIGAAIAMKLSRQGAVIFGGNRTLSAAERTKARIESEGGTCDVQQTDVTDSASICDLVESCMRKHGRIDILVNNVGKSEPGCPATMAEEVWDAQVDLNLKSVYNTCHFVLPIMEKQGSGAVVNVSSIAGLRYIGKPQIAYSTTKAAIMQFTKATAVMYADKGVRLNTVVPGLIYTPYTREMSKRYAPGGDEEEYMKMRDAQVPMGRMGDAWDVAHAAVFLASDEARYITGQEIVVDGGITSSTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZW5</accession>
    <name>A0A5N6TZW5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZW5"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="182"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="288"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="387" mass="44129" checksum="D87DD50C1EBA7903" modified="2020-04-22" version="1">MLAPRILRPVSSLVRPFTSSASVYRSPSIRDITPESAEEFNLRQKEFRENLEVARKKKEQQESQSVDASASASASSPVTRDRLREYATAPTAPGASNASSNHSPAVFDAAQVLDNKALGSLSTHRILGDEQQLEANQSPKRGPLSSLIYGTKEGQQLDKDIERSFSQVLARGKYVHSIVLHEVKPDKVEEYVSLVGEWYPRMAGTEENRVNLVGSWRTQVGDNDTFVHIWEYQRYEGYHASLHNISCHPEFPEFDRKLKSLIKSKKTSLMQEFSFWPTTPPRRLGGLFELRSYTLHPGNLLEWETHWRRGLSARREVMEGVGAWFVQIGDLNTVHHLWQFANLEERKIRREQSWGIEGWAETVHKTVPLIQSMQSRILIPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0L5</accession>
    <name>A0A5N6U0L5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_74761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0L5"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024897090" evidence="1">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="585" mass="63236" checksum="817F3DF30C7A7630" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U130</accession>
    <name>A0A5N6U130_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U130"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="242" mass="27570" checksum="8EAEA25107272836" modified="2020-04-22" version="1">MSRFLKPLTSTFTIKRLPLHKQEIDPEDDKTEPLMRDTSDYEATTTPKNNHKSHTRPFLLSLPALTTIILTSLLLGALALTTITLLNPAIRKALQQPPKKLHKPCGSTPSEARKAGCNFDVISFCWLPDACYDAELSRQFDDENRLEWFLDANRTLPLAHDEIMSGEYTGLYVNWEYHLRHCTAMWKKMHRAVLGGGRDAVDGYIGVYEHTEHCEKMLLGDRSIEWDVINTRIAVKFPDCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U149</accession>
    <name>A0A5N6U149_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U149"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="19773" checksum="8E31DDCF18A9D28B" modified="2020-04-22" version="1">MCDTSEIREKVFEKTEAQRLVIKVHTEQLDSHDYRVSASNFINEIFPNWENDHRIHFIAIEIRGDRTFLAIDVNNPNYDFATAHETKMVLPVYVIWRHKRKGWYVIRWPQEDEPLATKIAELHDLNGFDTTTPFLANFNESVVYRNPRYISVNRRHLQAISPSDECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U240</accession>
    <name>A0A5N6U240_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_128085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U240"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="570" mass="62869" checksum="2FD11327FC5F0B07" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U327</accession>
    <name>A0A5N6U327_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U327"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="77" mass="8188" checksum="165A9C8BA0A0F7ED" modified="2020-04-22" version="1">MPMLKVDLAPMHVPGLLSPILLVYRCVSANQRPVRDSPDTAKGCSAAVRWICQGYAGFILANGPMAIVNWCSGSVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U473</accession>
    <name>A0A5N6U473_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U473"/>
    <dbReference type="OrthoDB" id="4907280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024925052" description="Phospholipase D" evidence="1">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31934" checksum="ED71B5582DF3C2D1" modified="2020-04-22" version="1">MPSPSAIIRALCAICLLSQAIAISTQRPIFAIAHKVLRKEGVLAASAHGANALEVDLTAWYHEWWADHDGKPFSAGASARDLFHSIAEQRLSNTLNISFIWLDIKNPDFCAEGKACSIEGLRDLARETLEPAGIRVLYGFFQTAASRGYKVIRDTLNANEAIALSGETTEILYLYNATGGGVSARQRVMDFGDVWLSQGVDVYPQLRYGSWMRDQGALGKVFSWTSSERDTGMVRYLLREAGVDGFIYGYPMDEYRDADAPRAALKDIVEIVEAHPDTHRMATGDDVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4K9</accession>
    <name>A0A5N6U4K9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4K9"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="789" mass="88785" checksum="685463CEEAD5A043" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U583</accession>
    <name>A0A5N6U583_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U583"/>
    <dbReference type="OrthoDB" id="4466661at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="141" mass="15911" checksum="86DD280BF431F41B" modified="2020-04-22" version="1">MPIPLPQLRRLQTLLGCLILTTTIHYAHNYIRAEDYPPVPGIYPTPDAYRLGIIILYPLQTLCGIRGYYLYRDGHIRSSIPYLACHATLGIRTPGHFFGGVPQIPWFWFLTIFTDFFAGLWLAIFCYQAYISSGPSGGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5R7</accession>
    <name>A0A5N6U5R7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5R7"/>
    <dbReference type="OrthoDB" id="3553547at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="492" mass="56254" checksum="CDC1CD01FD56C272" modified="2020-04-22" version="1">MFARALGNIPKLGKSIYSLFVGDVYSHQNGRYKSEKRSPEPHAVKPKAQRRATASLPISQKAACEYKLQTDSEPFIPDLSPTSANGPIQAQEFHLIHYSEPAVPLHHQRSSYYEPSKTTDIGIPIPGISKDPQKSADVDDHLATHAAKVVHSKDKLQRLCQSSADKRIYARELRKDLSHKREKESQLREEFMKTICRGIAQDTLAPDKHLIEQFQDLRAATEDCRRHEPELKEVEDQLDLEDYRFIKAVDGDSLSSSDSSMASLDNLDMKGSNTSLVGYPPDLENYLSCVGEVRIQMERLQDLDVEWSNAQEKQRMWKELNRELDDETVEILQEYADRRKCICEDLNSTLEQLYRLQDICQRNGHLSDDYIRELGFHPNSLVYQTEDPLKGSTEAYPFTGPNMQQASKSEHMSKWMLHKLQQSNAEIRQLKSQPELQILRDKGYSEEQISRMSLATWHEDETAKRPSPSGASPTKYTGDYLQSSRISKGRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5Z2</accession>
    <name>A0A5N6U5Z2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_15217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
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</entry>
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    <accession>A0A5N6U674</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="23"/>
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    </feature>
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            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="EMBL" id="KAE8154098.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11186" checksum="5B14E9B3CFCB3085" modified="2020-04-22" version="1">MQLTNLLPFVLPLVGAAFGAEAASLPTFYSKPEYEGYSLQAPMGECVNTTPDPLVRVASALVPTDVVCELYSHNGCVGSAACNISASVSDFEGSACVEAGGVRAVYCF</sequence>
</entry>
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    <accession>A0A5N6U6F2</accession>
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        <submittedName>
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        <name evidence="6" type="ORF">BDV25DRAFT_148466</name>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein export from nucleus"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:RNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Exportin-5_C"/>
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        <property type="match status" value="1"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1230" mass="139560" checksum="32F106ED5D59053E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6H7</accession>
    <name>A0A5N6U6H7_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_121380</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6H7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF143">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="512" mass="56250" checksum="6BFD30D1B56B6922" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6R5</accession>
    <name>A0A5N6U6R5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_126702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6R5"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39993" checksum="9DA6C540B9045B64" modified="2020-04-22" version="1">MDTNALIDLVHEVQGQLWVDKVNETHRTGRLCQWVSTFHPDKLPCRLDGTFHHGAFNAGLKMVAMEVAALGFIRDRITIPVPTIYVWGLASSNPLGLSLFIMMDFINSVSLGDFFWDSSADRPSRVMREDIYNCDVKSIYRQLVNFLFQIFKLDFDEIGSLLLPQTGVYNPILPQPLTFKLYSILQNGGRFAITTEYFQYIIRQDWEQLVHQLNLIINKYNAKNKYIYNCYKFKLICNDLSLANLIVCSKGDFTVVRVLLQDRPVNSIWDYEGKETPKLAIWYFKYLDIFVYVLEEEEGKMPGYKEREISSLVKWLQASGSMWLYILLLSGFNNYCSFSFTRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U723</accession>
    <name>A0A5N6U723_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_126534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U723"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="37066" checksum="8D36B5F018771AA3" modified="2020-04-22" version="1">MQYNLNAELWAEFAIGMIVFVVRFYARWKTIGIRNFSWDDFFAALSVVFWTLETTFLYTCALHGNNITLNEETAELVRDSEVPLLEKGSQLAFAAWVFYILLVWSLKGVVIFLYSRITTGLWQHRLVKFVSIFCITTFLASFLLHFCQCVPIQRNWQVKPFPGDSCTKRTLNYIVIEVLNILTDASIITIPLPLILSAKLPLYRKIILGVLFSSGIFIIICAILRAYYSVKNIKDLSVALGWASREVFVSALAVCSPGIKPLFNKNRWFSSKQSSAERYYGSVSLRAKGSSYGWSMSRGRKQIKKRKNDQTGARSQDLMRVKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U730</accession>
    <name>A0A5N6U730_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41493" checksum="B5A37B850F1AEFCF" modified="2020-04-22" version="1">MASKYAHTFLKPQGPGDARPTAMQIIEDNNLKDKLHDKVILITGCSSGLGVATAQALSTTGATLYLTARNLKKAETALGDLAKQPKVHLLELDLNSLASVRAAAKNFLSQSSQLHILINNAGVMAAPEGRTEDGFETQFGTNHLAHFLLFNLLKPALLASSTPEFSSRVVNVSSMAHRAMEVNFDNLRLEGIYEPWMAYGQSKTANIWMANELNRRYGSQGLHAFSLHPGGIRTGIQQYISAEQKAAWEQSGSIDNIWQSPEQGAATTVWAAVAKELEGKGGKYLEDCQVIGLYDPATGCAGQGHASWAYDAAKEAKLWEVSSTLEDTVDLPLLGPNMKKACEYVPWGTNIWKSTLGPEGDRGEKSGKDAVNVKPTMDKVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U734</accession>
    <name>A0A5N6U734_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U734"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="520" mass="56571" checksum="B356B8D13F844E3E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U758</accession>
    <name>A0A5N6U758_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_172638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U758"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="GCP"/>
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        <property type="entry name" value="GCP5_N_ext"/>
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    <dbReference type="InterPro" id="IPR040457">
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        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="226"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="542"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="847" mass="96806" checksum="5C0492ADBB4D9428" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7E4</accession>
    <name>A0A5N6U7E4_ASPAV</name>
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        <submittedName>
            <fullName evidence="11">Cation diffusion facilitator family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_135743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
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    </dbReference>
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        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="228"/>
        </location>
    </feature>
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        <location>
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            <end position="257"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="398" mass="43851" checksum="4832F8635B3DDB76" modified="2020-04-22" version="1">MLIKISRIQRLSAVIGISLSFFIAEIAVGFYTGSLALVANAFHYVHHTALSLSDIVGFAIALIAAIVDEKHKPPPSLTFGWQRAQLLGAFFNGVLLFGLGISIFLQSIERFISLERVQNPKLVMIVGCVGFALNLISVIFLHEHEHGSGHRYNEDDSGHSHSYRYTGASQIPSEVVSQKHITHKHHTNSNTQPHKRYFYLALMGVLIHIMGDCANNIGVIISGLVIWLTHYNGRLYADPAVSMSIAIMIFLSSLPLVKRSGMILLQSAPDGVEHEDVKHDLEQIPGIQAVHELHIWCLNQTKSLASAHLVLGDENDIDFDQLARTVNECFHAYGIHSVTLQPEGLPSHRASSETLLAGRAVRVAIDRTMVGVTRRSDTNTGRQCQLVCGELCEKLSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7R8</accession>
    <name>A0A5N6U7R8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT hook motif protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7R8"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14026" checksum="2CD3738682C84A6F" modified="2020-04-22" version="1">MPITWTAETDAKLFLGFLAQCRSENFKPDYEKLAAHMGPEVTACAIQNRIIRLRRMVEDKAGSESAPTTPAKRKPGRPPKSATPTPKKVKEEGHGVEVQIVKKEKMDEKRGAKKEEDVFFDMGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7W9</accession>
    <name>A0A5N6U7W9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_148079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7W9"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="500" mass="57971" checksum="E724A26DD4F6252C" modified="2020-04-22" version="1">MILEEQRFIHEDLERLEQAVADRVADEPRNIRDRLARDHEVSQFLARIDEQSKRLLEMYKDADSAREKEIQSISTGDQFEQFYRQLDEIKDFHRRYPNEPVENLERAYKRREGESVGMDIDTMFTGEEGYGQFLDLTKAHEDYLNLPNVKRLTYVQYLDIFDAFTPPQFTIRRPNKLSDTYFKYVGELAGYLEEFVKKVRPLQDLDKLFASFDEEFEKQWAANEVPGWTEEQAETGAQGPKTEGSGEGIWCADCEKEFKNENVYKNHLTGKKHIRAAEARKAAGDSGEKPAATNGAGGVAYRLKERAVAEREHRVRSLAQALDSERQATKINVERKQGMTERERQMELEALLAESENAGGDRAGDQSDEDDEDRIYNPLKLPLAWDGKPIPYWLYKLHGLGVEYPCEVCGNFVYMGRRAFDKHFSEALHIFGLKCLGITSNTNLFREITKIDDAIRLWEKLEHDRKKDKDNRDNVVQMEDAEGNVMPERIYLDLQKQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U869</accession>
    <name>A0A5N6U869_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endo-chitosanase</fullName>
            <ecNumber evidence="11">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_146978</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall. Chitoolisaccharides produced by the hydrolysis of partially N-acetylated chitosan are known to have many biological activities, including antibacterial activity, immune-enhancing effects, and elicitor activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="11"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U869"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF4">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025096525" description="Endo-chitosanase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8154786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="292" mass="31138" checksum="562C89E02AF2C0AE" modified="2020-04-22" version="1">MKSLWSIFALILLFSGNSRGAKLEGSQYNHPDRGPPAELFTAAASLPVSAIQAAAATASAVPKDATYRINMYSSTKSNIHTDWTSFKEGAALSWVADMDVDCDGINDKCDGNPDGQPQTNWGALSAYAVPYIVIPDRYLAANKVLLPGNNIAAVICNGQMYYGILGDSNGDSPQITGEASWLMAKTCFPNERLKGDNAHSADDVTYIVFTGKDAVLPDSALNENYITNFDTLRSMGNKLSEALASNLGTRPTQTTTSTGTKTPDSAASSTLVSHTEVTAILPMIWAILMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9I3</accession>
    <name>A0A5N6U9I3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_135019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9I3"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8155272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="52916" checksum="B16B01A8CF56E9B4" modified="2020-04-22" version="1">MNERSPLLPSQTTNTVHPKSSYQKYKSTWTTWRIPLLCYSLALLLDSGEAMRATPKTRLFEMILCERYYTAVDTPLDSREIPETMCKVSEVQSAVVDTQVWLRIMESLFALITAIPFGKLSNTKGRKFVLILGISGQILAEAWILAVCYFRVPFGAVYASAVFKSLGGGEMVLSAIVHAILADAVSEDRRARAFFHTASMTLLAQVIAPLVGSALMQVRGVYAPLLCGFPVQVVAVAVSFLMPTSVDRVRGDAVVDGFAERAKPGFNSLTVTISRKIKTSWTLLRENSAILLVAVSFMATYSGKETLDFLVQYVSKRFGWSLAKANYLISFSAITNLTLYLLILPGITKTLATRYPPKNIDLWIARTSSIFGIIGPILLGLSPTPALLILSLVIFTLAFGYPHAIQSYGTSLVQPVDIAPFYSFLAMVRIAGRLVVSPLMAGSFTLGLKTGGVALGMPFYLAGVLFGVGGVAAWVGFGGSKISHIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9V1</accession>
    <name>A0A5N6U9V1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_1061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9V1"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="310" mass="36067" checksum="A9FD1ADF73B75122" modified="2020-04-22" version="1">MTAGPSPKPLRDLIRHHRELIVSPLLWTYRHLDLVGCRFEYADVNLGAMPDSSPEEQDLAEQLARNIFPVIKHRALVAILVGEGRPFVKHYIGSHFFFAGKPVHRPRYTVFHLRPPAFQHTPQISPPLIGYFHYTNVNGDRRRKFESCPDPRRRPDPIGGIICRKRLAQVTPPQWTEDPYFVCLLLALAQLQESKLKYKLTTYISRLLVVHVVDREYIYFYEAEITADLLCALRNPNAASSYTEWPTIRWRKIPYQPYETFANRLISTLVSPTPQGLHTDFKLSEIDHSDLKRSWDEESSNLQKLRRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UA91</accession>
    <name>A0A5N6UA91_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_126040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UA91"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8155081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="496" mass="55453" checksum="062189A6DC76F9B3" modified="2020-04-22" version="1">MSKPDQGPVEHHENIQKVGQSEQEVIYETYVSQSPEWHRKMTRQLLRKVDFHLLPCLIVMYLLNFLDRNNLSQARLGTLEQDLKMQGTDYNLATSILFVGYLLMQLPSNLLLTRVRPSLFLGITMAIWGVISACQAATQSFTGLVLARFFLGFVEAPFFPGAIMLMSSWYTRQELSHRIAWFYAGSSLANAFGGLIGAGVLGNLDGAHHISGWRWLFIIEGCITVGISLLSIFLLPNYPATTLWLDETEKLYAQWRLIHDAGEADEAKSSNFREALWMVFSDRRIYLFILLQHSSLLSQNFQYFFPTIVQTLGYGNIVTLLITAPVWIATFLVSLLVTWSSGRTNDRGLHIISLMLVSVVGCVICTATTNIGARFFGMFLMPMGAVSAYQIIIAWVANSFPRPLVKRSAAIATANMIGNTASIYGSYMWPSSSGPRYIAGGAATAGIALLVAFLACVIRMVHSRMNKRLDVELENDRSRVEAPGAETHHPRMRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDH4</accession>
    <name>A0A5N6TDH4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CENP-S associating centromere protein X-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_95612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742531">
        <property type="protein sequence ID" value="KAE8144423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDH4"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="202" mass="22162" checksum="AD916FC8C1F02EAB" modified="2020-04-22" version="1">MPPERKPFQKRRQLPFKPPSRQTPTPGPSTTAPTKKTTTTKPTKPTKPTSTTKANTKPKTKASSSKSLPPPPSESSDNNEEEEDDENDDENSSRSRSPSTEPTEPEFILAEINHGQNAEQDVVTSDPAIPGKLLTKLVHQHFKGEKSKIAKDANEAVAKYVDVFVREAIARAAFERAEGGIGDGFLEVEDLEKMAPQLVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDH8</accession>
    <name>A0A5N6TDH8_ASPAV</name>
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        <submittedName>
            <fullName evidence="19">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="19" type="ORF">BDV25DRAFT_166863</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
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        </location>
    </feature>
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            <end position="827"/>
        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="221"/>
        </location>
    </feature>
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            <end position="242"/>
        </location>
    </feature>
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        <location>
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            <end position="742"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8144435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="845" mass="94383" checksum="0996C6EB02DB2FED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE39</accession>
    <name>A0A5N6TE39_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_171275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="263" mass="29987" checksum="19E946B9FEB5C797" modified="2020-04-22" version="1">MKYFLLLFVFCLLLLTETVRASNTAGPAETLFLYNAYLIEFKTVSNSKRRKLAKGCRAAQVDAPCTYPAFLKHILAPKSKMQVDKPKFQDIINSADTAGVIETSKKLRENGFQCKYDLAALVEGIGRATPFSKVLATVEEQIKEKVSLPSVENEKNNIKTALKLVEQNRVADNMRWFNEELDKRMGVEFIKSSRTTDDGRVWQAYDTEKTQKKYPHYENFSEKAQEAVKAMRDTNFQVEDKGFAPHQAVVVKVKDILKRVNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEJ3</accession>
    <name>A0A5N6TEJ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_85932</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742434">
        <property type="protein sequence ID" value="KAE8144793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEJ3"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071469">
        <property type="term" value="P:cellular response to alkaline pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000993">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001369">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="372"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="600"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059033"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8144793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="662" mass="70846" checksum="B7C6A761E0867DA2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF06</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="KAE8144922.1"/>
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        <source>
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</entry>
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    <accession>A0A5N6TF07</accession>
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        <recommendedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742408">
        <property type="protein sequence ID" value="KAE8144964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF07"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47705" checksum="94D290BA28E20370" modified="2020-04-22" version="1">MARQRLPDARFINDRLWPYYNKSSQRQDVPQSIWCQKNIQEACLMRWFVEELAQWFDTCASSKPFSHVVPQRAEACPALLYAILSASARHLSRVQSTRAGEILCSGKKLPHLGDGVALEYQSLCISQLRSLSGDPSNVQDENLLAAAVILRFYEEVDSPLVGVDDETYLRGVQVFLHAQSATAMRDGGLRLAAFWVGIRQEFHTSFIRQRAFQFDLSCCDNTIYRFLTRSDDPTWANRAILHCADVLTYCFGNKKQPIEIYQQLWEFSQNWQLLVPSSFHPIYCREADQSKNQVFPEVWYLNDCSVTAIQHWHLARILLHAFDPRVPRVGLGRKKAVAQRDAEIIQSLFILCGIALSNRTAPALITACMGVSMCGDRVTDRLTQEALLMILIRTEDLHALSTVKTQMELQEAWGWTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF69</accession>
    <name>A0A5N6TF69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_145310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742443">
        <property type="protein sequence ID" value="KAE8144751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF69"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="238" mass="25568" checksum="C61DBB59AA4DEB8C" modified="2020-04-22" version="1">MSTITEKLQILQNYSACDVSDALLKLQKNPEGTTPRAGHLADFIPFSPTTDRTKLPKLIAPASTFKFIPKSSPDANPSDPSHSFPPGTHWVDSAEPGTITVIEQPEGQHCAVLGGVMAVRMKYLGVMGALVNGRIRDLGEIRECRLPVWARGTSTVGTAAEAKPGLRNVPVSLGGVDVSPGDIIFCDPVDGVVAIPHELLDRVLELMPKLVAMDDKVKEAVLQGSSVFEAFKTFRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF96</accession>
    <name>A0A5N6TF96_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_165508</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="ML742395">
        <property type="protein sequence ID" value="KAE8145043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF96"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000059">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="16">
        <location>
            <begin position="350"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1009"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8145043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141581" checksum="F5DB2F905634BD77" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFJ6</accession>
    <name>A0A5N6TFJ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-D-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_134163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742401">
        <property type="protein sequence ID" value="KAE8145010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFJ6"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="338" mass="38475" checksum="E6743526009E696E" modified="2020-04-22" version="1">MPAAKNILVTGGAGFIGGWFIRHMLQVHGDRYTLICFDKLDYCASTSNFTSIKRHHNFYFVKGDICNTLDVEEALRTYNIDAIVHFAAQSHVDKSLIDPISFSRTNVLGTQVLLETARRFNTIKRFIHVSTDEVYGENDDQDPVAFAENQGLCPTNPYSASKAAAEMIVQAYRKSFQMPLIIARCNNVFGPHQYPEKLIPKFITLLNQGKKMPIQGNGRNSRAFLWAGDAAEAFDVIFHKGSDGETYNISSEDRLQVLRVAQKILEYFDLCSAPRLEDWIEPVADRPFNDSMYWTDDSKLRALGWRQRTEFDDGLRQTVEWYCLHSDGFWSEAESNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGA7</accession>
    <name>A0A5N6TGA7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_170796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742383">
        <property type="protein sequence ID" value="KAE8145131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGA7"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="260"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="422" mass="47146" checksum="6DC1C787AA12A796" modified="2020-04-22" version="1">MSQIDNVASDGHSEGHRKLKNAYEIALLPVGVNKIADLVNKVIPESKSSPLENMNARWRLRDAARSLANALETPREAIVRQCWSEPTIYAAIEVAIDLGIFALLARCARPMSDAEIASATETNPVLLARILKHLAATGIIGETGPDEYCSTSLSVQKNIATFSQSCNSRWFFPGIYALPTFLKETKYGDPSDTSKSAFKRGLETDRHLFELVRQNPLLAKQFSHLMSVYRRGKPDWMDKGFYPVRERLTEGVDIKGDDVLLVDVGGNTGNDLCQFKRKWPDVPGRLILQDLPEVVDAVKGLPASIEPMAYDFFTVQPVQGARAYYMHFIFHDWPDEICREILSNIIPAMTPGYSKILINEHIVPSTGAYCETTSLDMIMMTLGSRERTEDHWIKLLTSVGLKIVEIWSAQKGVESLIECELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGJ3</accession>
    <name>A0A5N6TGJ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_164551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742339">
        <property type="protein sequence ID" value="KAE8145508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGJ3"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20545">
        <property type="entry name" value="CYCLIN_SpCG1C-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000201">
        <property type="entry name" value="Cyclin pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="179"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="523" mass="58532" checksum="562ABD0D4673346E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGY7</accession>
    <name>A0A5N6TGY7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="ML742325">
        <property type="protein sequence ID" value="KAE8145644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGY7"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="233" mass="25548" checksum="11A5EF335BFC5C52" modified="2020-04-22" version="1">MKPTNNPLTLIVATTPIPRNDKLVLGIGLNGTLPWPRIKADMSFFARVTSRAPRPDTHNAIIMGRKTYDSVPAHLRPLGKRVNVIVTRDASGDVSRTVMGELEAKKAKTGGEPTQPVTDAIVGGGLEEALAGVEGKYGADLGRVYVIGGAEIYRGALGVRGRKVRIVMTNVEKKEGLFECDTFFPVDEELVQEKGWRRVSDQEVTEWVGEDVSSEWKEEGDVRIQMVGYERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGZ6</accession>
    <name>A0A5N6TGZ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_68400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742332">
        <property type="protein sequence ID" value="KAE8145577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGZ6"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="184"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="785" mass="89811" checksum="46E7B751D9F563EE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH78</accession>
    <name>A0A5N6TH78_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_164124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742322">
        <property type="protein sequence ID" value="KAE8145682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH78"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="19881" checksum="D9F5B0C70A8B6CEF" modified="2020-04-22" version="1">MFFCSAQCSSHRDLSARHFDLPVRMILQCPHANQDPWQTLLPIAVEMCNTSSRENSMIRQGWRAVKARKMGGKGSGREKRRRNVSTFVFYSKRQIVTDHATNDIPLFEPKNSQTIIQNKSKQNGLRFGHRGLALVSNRTIGKVWSPLHDEIASCQKRKEFNSSARQMRDYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THL3</accession>
    <name>A0A5N6THL3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_61113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742309">
        <property type="protein sequence ID" value="KAE8145826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THL3"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="364" mass="40995" checksum="C3D5B41A28F5BE84" modified="2020-04-22" version="1">MAGAVRQPIDIPSLERYISQNVPEIQTPLDIKQFAFGQSNPTYQLTGADGKRYVLRKKPPGKLLSKAAHKVEREYKIIHALEQTDVPVPKAYCLCQDSNVIGTPFYIMEFLDGRLFTDPAMPGISAEERNALWKAAVQTLAKFHRVSPKSVGLESFGKPSGYYDRQISTFTAVSKAQSQAVDIETKEPVGELPHFMDMVNFFADKATQPKDRGTLVHGDYKIDNMIFHKTEPRVIGILDWEMATVGHPLSDFCNLTSPFYLEGTHHNTENFQPGSTPGLPTREDCVRWYSELAGWDPTSDIPWGDAFFAWRTSIIIQGVKARYALRQASSAQAYEHAQKAIPFAWRAWERVKNVQSAMRPKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY7</accession>
    <name>A0A5N6THY7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_144353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742315">
        <property type="protein sequence ID" value="KAE8145759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975460" description="SGNH hydrolase-type esterase domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="52"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150886" checksum="2304C1F221EA45A9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI46</accession>
    <name>A0A5N6TI46_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742295">
        <property type="protein sequence ID" value="KAE8145997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI46"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="46883" checksum="DE073AFB716AD179" modified="2020-04-22" version="1">MKGIAIRGQKVSRPQALICQFCQPSTSSTSRPRTNFTRSFASNRPFTPNKSIGSWKTPAELRSRWTPAQVILRRAASTATSPPASLDVEDALRQIKRESSELRKLDSVPSNESVVKLLERCQQIAESLVHQEHEIAKEDDGEISNLLDLEEKAASKKQSKSPKNADPRLANFLTQITYDILTDAKVFISPEALACYTKIQTLLKRAEHFPEIFHLYAHKPVPEENSSPVKYHKANPKDINSAIPTNLAEMALDVAIEQKNLSLVLAITDNTFCASAFQRAKIFKKAAVPLGGLAAAPAACYAAASWAATLQNTMDPSTATGIAFAASLAYVGGVSSVGFLAITTANDQMERVTWQPGVPLRHRWLREEERATMDRVALAWGFKDVYMRGEEEGEEWETLREFIEILQRWFYKQDKFRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI66</accession>
    <name>A0A5N6TI66_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkaline protease 1</fullName>
            <ecNumber evidence="5">3.4.21.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Aspergillopeptidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Aspergillus proteinase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Elastase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Elastinolytic serine proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Oryzin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BDV25DRAFT_170054</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Secreted alkaline protease that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt &gt; Ac-Tyr-OEt. Does not hydrolyze peptide amides.</text>
            <dbReference type="EC" id="3.4.21.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.63" evidence="5"/>
    <dbReference type="EMBL" id="ML742289">
        <property type="protein sequence ID" value="KAE8146064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI66"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000008">
        <property type="entry name" value="Alkaline protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20 21" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 20 21" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888611" description="Alkaline protease 1" evidence="23">
        <location>
            <begin position="21"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="24">
        <location>
            <begin position="451"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="20">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="20">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="20">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAE8146064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="845" mass="90940" checksum="545D9C3071ABC11A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIH3</accession>
    <name>A0A5N6TIH3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742303">
        <property type="protein sequence ID" value="KAE8145901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIH3"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="61"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="475" mass="51547" checksum="50DDE2AF98C7153E" modified="2020-04-22" version="1">MAYREGITDYETNKVNNKAMEAGAENYAVPPNYEGEKDIVGEMSERERDIVEDGIHKFNRLGWKRLTVVLIVEAVALGSLSIPSSYAKLGMVAGVICTVGLGLVAVYTSYLIGLVKLKYPHVAHYPDAGQLMFGRFGKELINVMLILELLFLTGSHCLTGTIAFVNITSSSICSVVWGVISAIILLALAVPPSFTEMAILGYVDFVSIIVAIGITIIGTGIKSNKEVGLSNVEWSAWPQEGLTFTDGFIAISNIIFAYSFALCQFSFMDEMHTPKDYIKSIWTLGAVEIMIYTLTGSLIYAFVGTDVGSPALLSAGNMLSKVAFGLALPVIFISGSINTVVLGRLVHGRIFKNSPIRFINTKMGWITWLAVITVATIVAFVIAEVIPFFNDLLSICSALFVSGFTFYFPALMWFILLREGKWTEPKNLALGAINLVVLLIGLITLVGGTYSSIDDIILNYRSGSVRGVFSCAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIP1</accession>
    <name>A0A5N6TIP1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_54750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742280">
        <property type="protein sequence ID" value="KAE8146202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIP1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="502" mass="54733" checksum="39094431591A44E2" modified="2020-04-22" version="1">MTESFDPDEDRRSPGLEISRPDFQYKDPTPPFVIKDLEGEAKPPAGEGTSDCSRKNQSSISQFESAEPNSVLISHLEPNRPDIANHERSDPLRPEHFRDGGPWEMSKSDKSKPENSVFVPLKPIAPQSSPADHDDAAAKAQHALALLEPKAKPSEGAPETPEVVPAKLSSPDALKAEPISPKIPQPPPAPHGLPEIKPFSPALSQYAIHSSQIHSSDDILRPLHTPDNTTTLPPIKTALRELSHVKEPAGRVNGSSPYALPPVTAASPPVIRTESVWDHQRAGPFVPSQVPPSPYSHLSPASTKDLSAVSSPASQSTYFRPSIKSDIPYLTYAHEVAHSTAKSPATSYPTPTDQTPTGPCERSSFNPNPQSNGAVATGAFKCRHPGCTAPPFQTQYLLNSHANVHSQDRPHFCPIEGCPRGIGGKGFKRKNEMIRHGLVHNSPGYVCPFCPDQQHKYPRPDNLQRHVRVHHVDKSKDDPALRQVLSQRPEGSARGRRRRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ85</accession>
    <name>A0A5N6TJ85_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_55155</name>
    </gene>
    <organism evidence="4 5">
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="8 9">IBT 18842</strain>
        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742248">
        <property type="protein sequence ID" value="KAE8146680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK81"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="242" mass="26198" checksum="3A64A99725370E9F" modified="2020-04-22" version="1">MADRFPSLEDFSAGQTEVVDTNGASDADDFLARERAVLGDDAEQFTTAQDHVAENVDAGDDLLGGADDVPVGAGPEMSGFESSFPAVETQNEQVAPGGMITGTGAPFPPTGYSSYQQPEEEAEPVREWRERRDADLQRRAEISEEKKESNVNKAREDIDDFYVSYNNKTDKLRAQTRADAEQFLANREDTSSGGTSWERIAKLVDVSGKGPKGGANGSGKVRFREMLVDLRKDQNAPGVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKC3</accession>
    <name>A0A5N6TKC3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742241">
        <property type="protein sequence ID" value="KAE8146804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKC3"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="36333" checksum="D6E5ED4A51BE9B19" modified="2020-04-22" version="1">MGKSYLDLINELDKFPYYENNPAFYTTHLKNFHAFKVNGCDVVLGYILNSVVAKFQWPAEHWAIDSTDQTVTLTTPADATPEQRSQAVAETLEKEAKRGTFEVLKGWRNENYAVYAPGGKFLLDMERSATPLFGVVSYGVHGTCYVEDENGLRFWVPRRSKTKQTYPGMLDNSVAGGMSAGEQPFECFVREASEEASLPEDVVKANTKTVGCITYFYVRDSRAGGETDLLQPEVEYIYDVKLSADTIPKPCDTEVEEFNLYTIEETKQALANGEFKPNCAVVFIDFFIRHGILTPENEPDYMELVTRMHRRFEFPTASFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKN8</accession>
    <name>A0A5N6TKN8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_162030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742248">
        <property type="protein sequence ID" value="KAE8146679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKN8"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="199"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="378"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="486" mass="54018" checksum="30B50A7441B15117" modified="2020-04-22" version="1">MVLDYSKWDALELSDDSDVEVHPNVDKRSFIRAKQAQIHQQREQRRLEIETLKYERIVNDGLLSRIDRLLKLLQQHEGSSKNPEEVVFEALMEFSSDPSNDQPPAPPAGVHAQEKEQPKYSQMMSALVDQVKKEMGEVSAESLYKEYIKGVQGHQDKVKGLQKELLARLAQLEKEEGSKITSDQLHTGFDTSFVAKDDAKGKGAEPKTESVELLNPGAASGGPSDKAAADDEEEDPENMKASDLAKKFAKISQNDYRTLLQFISENPQIVAERETDGLLVEAFNSQMAGKAEYARQCVHQGLLLQYCRSLGRDGISLFFKRITTKDHQASTLFRNDVNETYNKIKTRAAELSKETPTDPAGVEQIQLHAVDPNTKITINIPSAESTEPVEVEARKIFESFSKDLQTALSSESLDEVNKVLGKLSVEEAEDVVEKLGESGMLSLEEGIVDATTEEGRKKLEELEAEGKKESKIEEIGEPGGDVAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLC1</accession>
    <name>A0A5N6TLC1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pectate lyase superfamily protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_169358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742222">
        <property type="protein sequence ID" value="KAE8147152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLC1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000043">
        <property type="entry name" value="Exo-beta-1,3-glucanase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025046528" evidence="5">
        <location>
            <begin position="20"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="88"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="430"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="796" mass="84536" checksum="B836C732200D188C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLC7</accession>
    <name>A0A5N6TLC7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CVNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_39095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742222">
        <property type="protein sequence ID" value="KAE8147156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLC7"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF8">
        <property type="entry name" value="RICH PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="264"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="367" mass="39681" checksum="C8891C6542A431F8" modified="2020-04-22" version="1">MTVHKYVGGEHPPTNRDPDQQASNQPSDAPWSPPPPHTPVPNNYRPSPPPNGYPAESNPGYGPSNYYPPPPGPDRSQGPYPPWPTYAYPPQQSYAPYNPYGPQPPYPTYHEPPLGPSQPSFVPSPRPEYAAPASQPPPPPPYTTGPETTPPGPDEKDRGLLGAVAGGAAGAYAGHQVHHGLLGAIGGAMTGHVAQDALKKHKEKKEEKKKKKWSTGSKSSDSSLSSSSSSSSSSSSSSEDEKKEKKRKKKEKKEKKKGKGKVGKFSASSQNIRVENGHLLASCRGKHGEWKHARFSLDRVLANHWGNFAWALDGNFSATARNPTLQKRDKGLVLRADLADGKGNWKSSEINLDERLANTDGNLVFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLR0</accession>
    <name>A0A5N6TLR0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AEX-3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_36153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
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    </dbReference>
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        <property type="entry name" value="uDENN"/>
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            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147278.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="917" mass="103452" checksum="431A3271A2BCE104" modified="2020-04-22" version="1"> </sequence>
</entry>
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    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_33719</name>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742209">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="279" mass="30041" checksum="72D8827BB0E64CA7" modified="2020-04-22" version="1">MPRPTTRQEVLDRLRKTIAEGKIIVGAGAGIGLTAKFIEKGGADLILVYNSGRFRMAGRGSLAGMMPYSDANQVVVEMASEVLPIVKNTPVLAGVCGTDPFRDMTAFLQELKLLGFVGVQNFPTVGLIDGKFRQNLEETGMGYDREVEMIRIAREMDLVTTPYAFTVDEGERMARAGADVIVVHVGLTTSGTIGAQTALSLDDSVAVIQEIRDAVVKINPEVIVLCHGGPLAGPEDAEYVLTRTRGVHGFYGASSMERLPVEMAIQENAAAFKRLKVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM36</accession>
    <name>A0A5N6TM36_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_160379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19114" checksum="96153B75B43F52E8" modified="2020-04-22" version="1">MFFHSLTTALLGTTVAAAAAITTTTTSTLNPSTLNVTVIAAHNNKSTLECWALEPGFESSNTPGTTGNPVLSLGAPSANISYMAIPPRTDGGLHNAPTIQWVSFVSGKAHVTLPHSDDEAWVTGGEFGTILAIDTEDVSADGHFTEYPSDEVTVALAMPVKEVPGHRVLHAGACTRREQKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMH4</accession>
    <name>A0A5N6TMH4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F0 complex, subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742202">
        <property type="protein sequence ID" value="KAE8147545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMH4"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="58" mass="6402" checksum="462610009F411F2D" modified="2020-04-22" version="1">MSSILGKKFPTPIAKPLGPFFAAGLVILYGINSFGNVLMNTEEFKNDPRNPNLKNNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNJ2</accession>
    <name>A0A5N6TNJ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_25786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNJ2"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="392" mass="43054" checksum="E57A68DF8A4224E1" modified="2020-04-22" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCITPDKRYLAAAGHNNVKLYDIKSTNPNPVMTFDGHTNNITGVAFHCEGKWMVTSSEDGTVKVWDTRTGSLQRNYAHKAPVNDVVIHPNQGELISGDRAGIVRVWDLGESVCTHQLIPEDDVAVQSVSVASDGSLLCAGNKKGNVYIWRMIQDAELTRIVPICTFQAHKDYLTRILLSPDVKHLATCSADHTAKVWNLDLDYPPAKIAAAQAAKAKARGITSETREVPSSPVPSESQVNTPSSDKGRADFINPFALLNGTPPPTTEPQQTFPVQPDGPPIDPNTATLYLETTLANHQRWVWDCAFSADSAYLVTVSSDHYARLWELASGQVIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNV5</accession>
    <name>A0A5N6TNV5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET and MYND domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_159114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742178">
        <property type="protein sequence ID" value="KAE8148046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNV5"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="55309" checksum="6C314B8FDD8502B2" modified="2020-04-22" version="1">MSVDITPLSVRTKTTPGPAPGGLGRGLFATSTIQSGEDILTVSTPFVAVLDTQRLGDTCSGCLGRSSLEPQDNLRACTACQVVKYCDKTCQAKDWKFAHQLECRIFQKLKPNILPNNARAMLRMVLRSKRGKYDGEELELFSQLDTHIKEIREENPDQWERISLSSKAVKAYSATPMSEEAIAAYGARLDMNAFNLVDAFYDRIGLYVHPYAAIINHDCNPNAVTGFDGDTLYIKALRAIQKDEQICITYIDVTESVQVRRTQLRDRYFFDCGCSKCKADLAQPPYSFLPNPSAQAPMTPDITEAMAHGILEQCAGGEPDEAAAAAPRLETTMRALHDATWPITHQPLLTLRDELINSLICGGRYNAGFIHAAIRYRRVDPIVYPSATHPVRQLHAWVLVRLATFLLGDIKPEKDCPVALETLELDLSLLIWSILSKIMSELDVACVVPGFASMVRERFESATEQFSGAGLDPERMGDEIEREWGKLEKAMSIVVDGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPR7</accession>
    <name>A0A5N6TPR7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_168529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPR7"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="410" mass="43980" checksum="3D91CC2091FB03A5" modified="2020-04-22" version="1">MYHPQPYPEGGLRANLIVLGSFSAIMGGLGLMNSIGIYQAWISTHQLAHLSDSQISWIFGLYNFLVFFSGIQIGPVFDAHGPRFLMLTGSTLLVLVFVLLGFCHAYWHFVVVLGLLAGLGTSFIFIVPVATIGHYFCVRRGAATGLAMSAGSIGGVIFPLVLENLAPTLGFAWTTRVIGLITLFLLIPGCILLRPRLPPKPASGTALLPDLAILKDPALAVTTLGAFFIEWGFFIPLEYITSYSLTYGIAPRLAYLMVVFLNAGSFPGRWIPGILADRVGRFEMLALTNVLCLVAVLGIWLPADGNVVATIVFAVVFGIGSGSNISLVPVCVGELCPVESYGRFYTTVYTVVSLGALTGVPIAGEIIRRCDGQYWGLIVFAGCAYAAGLMCFVAVILVRGRRKTVDTVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPU2</accession>
    <name>A0A5N6TPU2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_168508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPU2"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="200" mass="21544" checksum="5C1E3D7527F86F23" modified="2020-04-22" version="1">MADILTQLQTCLDQLATQFYATIGYLVTYHDNSPAIPPPNDSSAAPALSKIPKNSTAPPAPASAPAAAQAAQASPTQQPAQIPGQPHPSAETGQATPGGTGAADPNLPPVPDSPRTFASRQRELARDLVIKEQQIEYLISVLPGIDSSEAEQEKRIRELERELRGAEEQRESRVRELRRLRRRLEGVLGAVEVGVYGQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ37</accession>
    <name>A0A5N6TQ37_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_158385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ML742162">
        <property type="protein sequence ID" value="KAE8148407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ37"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="283"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119667" checksum="B258EBD86ACB75A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR85</accession>
    <name>A0A5N6TR85_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742143">
        <property type="protein sequence ID" value="KAE8148863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR85"/>
    <dbReference type="OrthoDB" id="4377801at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025039445" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7034" checksum="5617D3F42D1ACD63" modified="2020-04-22" version="1">MNLTYLLSVVGLATFAMAQYDDPCGSAKQCIKDCPHSDFFPMIDECDKDKHGNPSCYVNFYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRD8</accession>
    <name>A0A5N6TRD8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRD8"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="198"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="403" mass="44488" checksum="CFDD7928496E4FD2" modified="2020-04-22" version="1">MAGNSSNISLSSNNVEFCTLGMFILDDIDFDGSRPNVKNVLGGAASFAVVGARLVAGKENSRSVSWIVDVGSDFPAAVLDVINAWETACVIRKDDGRLTTRAWNGYGPNEKRDFKYLTPKLRLEPSMLSDAQVFSKTFHMVCSAERCVFIVQSILQRREKLRREGKTPAYSQNDKRPFFIWEPVPDLCTPEEQEKFFVASRVVDVVSPNELELGMMFGQPGWHEESKFGKDIVAQILASGIGPESTGHLVIRAGKDGSYAFSRGRRLWLPAYHQPNTSGATAVVDPTGAGNSFLGALAQGMVSAERNPAKTIGSILTESAIWKKAMEAWGEQAYVLSSLIFATVAAGFVVEQIGVPHLSTSTDGTNHESEFWNGTEFTERVRLYTERLYRTFEETPQKHLQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSG3</accession>
    <name>A0A5N6TSG3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742128">
        <property type="protein sequence ID" value="KAE8149296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSG3"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="121"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="520"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="10">
        <location>
            <begin position="698"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="334"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="811" mass="89755" checksum="F3475A52C31A407D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSN1</accession>
    <name>A0A5N6TSN1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_3284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8149365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSN1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000181">
        <property type="entry name" value="NmrA-like family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="306" mass="33641" checksum="932FC6F2CA8FEB55" modified="2020-04-22" version="1">MSKLITVFGATGNQGGSVINHILADALLSKEFKIRGITRDTNKPAAQDLQQRGVEVVTADLNSTSSLRTALEGSHTVFLVTNYWEYFSKETELQQGKNVADVSKELGVQHLIFSSLIHVTDSTAGKLSHVPHFDGKADIEKYIRASGVPSTFVLAGYFMNNYLQMFRKGDDGTFQLFYPVDGAKAKFPLFDAASDTGLFVKAVLKHASELNDGKQVLEAAGYYTAEEIVATFSEVTGKKAVFVPVSGEQYKAVLPPAVAQEFLENHLLIEEPGYFLGKSLDDSLKLLDEKPTSWADYVKKNISTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSP7</accession>
    <name>A0A5N6TSP7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSP7"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72679" checksum="0F25D540EE839905" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTG2</accession>
    <name>A0A5N6TTG2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_156084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTG2"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52583" checksum="D3DC3BB33EC68A53" modified="2020-04-22" version="1">MAPKGGAVDLPIILSTGGKKCDPDTRKLIRSHVMLGKNRGKSRRAKCDDVKVVPPKGRHAVQEKQSSSPTEPFGCIPMKVGSEASLVPFADNVDPSLAVDILKFTAISKSVMFRLEMCTMFHKKKGLWYDLLMLDAAYLHTMAFVAEDFFGRILTLHPSRANPPTSVHFLKTLRLLRERLSYGAEEVKTSDATIMIILFLSTHAHITGDLESAMHHLKGLHRIVTLRGGIIDFTDDLKLKSEIFRCDLSIALHNSTTPLFFHDPLGLTVPCPPSAESDNERFLCKIDNNLARVWSVMKRFSQLINFAAETNQKLPMETLVDTMASVMYRLLNMRFEKDTIAEAVRLGLLGFSSSVFLQWQNIKQAYLRLADTYKECLVNLKSLNGVSSHIMLWLLMVGATSIFTDSDKEWLESWLRVNLQLCRVASWPSFRKIMASYMWIGMVHDQPGEEIFNSVTSSRALESRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTS9</accession>
    <name>A0A5N6TTS9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative autophagy protein Atg20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742121">
        <property type="protein sequence ID" value="KAE8149481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTS9"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="98"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="636" mass="70579" checksum="444268A678D29408" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU69</accession>
    <name>A0A5N6TU69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_155628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU69"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="33669" checksum="51090F4F2D7E2D16" modified="2020-04-22" version="1">MGTLLGQPDQSWGSRLHCLGRYSWHLLAAYLALLGMVLLLVSKLQDERLVSMKDKSHAPFAPSHSSASSALVLAKTRKEDVSWLYGLQPQWTPHIYSADGEPGYLALPDNKGREAMAYLTHIIDNYDSLADVTTFIHASGTQWHNDIGNTSTTHLLSRLRLDAVERKEYTNLRCQHIPGCPIAVRPFDPELRASDNAVYQNFVKIYMELFNVSIKQIPQEIGGVCCGQFAVTRDRIRQRPREDYIYMRDWALTTDLDNFTVGSVFEMLWHIIFSENPISCPDTQQCYCDLYGMCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUK2</accession>
    <name>A0A5N6TUK2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_155315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUK2"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
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        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
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        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S8e"/>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="261" mass="29845" checksum="B226378C16DD175E" modified="2020-04-22" version="1">MPQNEYIERWQKQHGKRLDHDERVRKRHAREAHQQSKDAQNLRGLRAKLYQQKRHAEKIQMRKRIKAQEEKNVKSSAPDEPSKTPLPQYLLDRSQATNAKALSSAIKDKRKEQAAKFAVPLPKVKGISEEEMFKVVNTGKKTHKKSWKRMITKPTFVGNDFTRVNPKRERFIRPMGLRYKKANVTHPELAVTVQLPIVSVKKNPQNPLYTSLGVLTKGTVIEVNVSELGIVTTSGKVVWAKYAQVTNNPENDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV39</accession>
    <name>A0A5N6TV39_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_115089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="197" mass="20580" checksum="3A8B178942556E60" modified="2020-04-22" version="1">MHYIIPAITLLSTALAAPAPDLLKDLFQKPSTTAQSLAAAATTSTATAVDTATETTPKNNTITLSSLLDLGNCNPLGCAKEITDIVFSCTGAIMGHGINVPADVNCVANSIKVGIPTANNDCTTCLNDALGKVLAVTGKVVDDFKEWKEEDEKKSEKNGEGGKKECHECEARVSMSMASYSSSLVVMPSPTPFSARV</sequence>
</entry>
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    <accession>A0A5N6TV60</accession>
    <name>A0A5N6TV60_ASPAV</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4400538at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="73" mass="8278" checksum="F3F5E99C6BEF0DCB" modified="2020-04-22" version="1">MSVTVQLVRPMIRHFSVRRPRPDTRTARFVTSSCLFSAVVLPFIPPALESSRAKSMGHSEHNKPHPPLCFHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVF6</accession>
    <name>A0A5N6TVF6_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">Putative DUF1212 domain membrane protein Prm10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_114244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8150254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="408"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="858" mass="93380" checksum="C624476BC6DAEB29" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVG1</accession>
    <name>A0A5N6TVG1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_129676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVG1"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024999436" description="Cytochrome b mRNA-processing protein 4" evidence="13">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8150264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="116" mass="13660" checksum="FEC131A22F46D178" modified="2020-04-22" version="1">MSRAGTWIKMFVVGTAICVGGPAFVQSIRPTDEELFKRYNPELQKRSLEEGDRRAQEFDEYVTRLKQWSKSDKSIWFAAQEMQEQKRIQAETQRSQAKDEAKTQREEMRKELLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW46</accession>
    <name>A0A5N6TW46_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_129644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742097">
        <property type="protein sequence ID" value="KAE8150299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW46"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000062">
        <property type="entry name" value="rRNA processing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="592"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1202" mass="135005" checksum="2CBF38986A952113" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX93</accession>
    <name>A0A5N6TX93_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_171740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX93"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="477"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="484" mass="52500" checksum="B78FD09912042DB3" modified="2020-04-22" version="1">MSPQFEHAGPPKEGEIAVSPTASDISNHIVDWDGDDDPANPMNWSKARKITIIALVSFASCNDAVASSLFAPSVPGIMEEFHETNPAISPFLISVHTIGFATGPVFFSPLSEIYGRCPILYASNVLSFVAAILCAVSVDIPMLAIARIILGFAGSVPFVLGGGVIADMIPLERRGRSIALLSTGTLLHVLTDWAGPVLGGYMALGAGWRWTFWLATITIGCCTVLSFVLLRETYAPVLLKKKAWRLGIAKELINSETTGQALRKAFTRSIKLVFQTPIVAILTVYNGISYAYFYFLITTFPSLYGELYGFNTGEIGLTYLGISAGFLVGQLTIGPFTDWYIKRQKTVHGKAQPEDRLPPMVLGHIALAVGMFWYGWSAQVRTHWIVPILGSVVVSLGIIVNAIVVVAYLVDTFTVYAASAVAINNLFKATFGAFLPMTGPSMYGRLGYGWGNTTLGLIVLVLTPTTLLVMKYGEKIRHRYPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXF0</accession>
    <name>A0A5N6TXF0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_153283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8151053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXF0"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPP6 N-terminal domain-like"/>
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            <begin position="715"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="725" mass="79960" checksum="7FE7AE4ACE89D3FD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXL9</accession>
    <name>A0A5N6TXL9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXL9"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="256" mass="28467" checksum="9E07D4FB9CA00347" modified="2020-04-22" version="1">MSDESEALYKPYDQFILFGDSITQQSSNPETGFGIHGALQNDYIRHLDVINRGFSGYNTAHALKVFPKFFPTPERATVRIMVIFFGANDACVPSSAQHVPLDVYKENLKTIIQHPATVAQNPRIVLLTPTPVDQYQLQGFDESKGSPHPSRTASHTKLYAEAVREVGSSLGVPVADVWSAFMSAVGWKEGETLPGSRDLPEIKTFRDSLPMVCLHLTADGYQVVYDTITEAIRVNWPDQQPAQLRMIHPGWLDAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXY5</accession>
    <name>A0A5N6TXY5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_97640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXY5"/>
    <dbReference type="OrthoDB" id="5376710at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="539" mass="60451" checksum="1ACBD1F833A997BE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY84</accession>
    <name>A0A5N6TY84_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_128891</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="472"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="783"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1267"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="17">
        <location>
            <begin position="1479"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="15">
        <location>
            <begin position="1766"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8151287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1975" mass="221544" checksum="235CAD6C08B98AFD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY87</accession>
    <name>A0A5N6TY87_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY87"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33405" checksum="6D4155C0B8D8FF44" modified="2020-04-22" version="1">MATDFYTASVTKLPKPGIRSTRHWSRSISSLPASITPSQGEIKTRQLSPQNVATAIRSLYHDGLVVVEDVIPHDSLNRLNQKMVTDAYTLQSKKENSPYKYNPGNIQQDAPPVLKYFDPETFLNPIATQITSTALDPRPNHSDADFDHPDHPFAYVVNIPLITMTPENGSTELWLGTHTDSGLHVQEGVHGDRASGRIMPNELERRRAIRPPSQPAVHKKSLFLRDLRLWHAGVAMIHFAPWYRNPMRLELAEDLRLMIEGQSSLEVPVDWVSEADATLRYLTRTFGNSYDFSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYM3</accession>
    <name>A0A5N6TYM3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_138857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYM3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="561" mass="63550" checksum="886305A32105737C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYP1</accession>
    <name>A0A5N6TYP1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_152617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="ML742070">
        <property type="protein sequence ID" value="KAE8151498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYP1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="116"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8151498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="392" mass="44328" checksum="DB0CC9C56130601A" modified="2020-04-22" version="1">MATRTLESRFEHLSVKDENAQGGPCNGLYKNKGSLSTAVSLSGLGSTAQLSSGSNRSNLLKLALQNTNDNKVNSINIGASPIKAQCHRNVDENGDQRQQTSLYDNSAPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFQDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPGSQDNYYNEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMAVPSFVSPEARDLIKRLLVLDPEKRISLDEIQKHPWILKHCLKDDRLTKRTSGSSKEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYP3</accession>
    <name>A0A5N6TYP3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYP3"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08994">
        <property type="entry name" value="GH43_62_32_68_117_130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="410" mass="46370" checksum="282A8A3E838EB600" modified="2020-04-22" version="1">MSQAQGCFHLRHGTKYGTSLVFTLRAVCACQTDEDCSLNGVCVPNTGPQPKGSNHTELKACQCDPGWTSADCGKLDLAPATRFAGYNHTNVTDPSYFGNNGNSSWGGQILQDPDNEKLFHLFISQFSYGCGLSGWRPHSFIIRAESHTGPQGPYHYAQTVTQPFRHNPCIVYSPAEEKYLLYSIGVDAPEPTKCGSISYTKWPNNISVSAADSLYGPWSDFEMILSSVEPHSTNPAPWPLWTPDDQTSKIMLGVEGNAVYVADKYNSDYRLIHTPTWNTTRYSPTWTEDPFFWRDKRGNWHILTHWMIDLVEHDGQQWPRVGAHMYSRSLEGPWHFKLQEAFSSVVEFTDGSVQTFKRRERPKLFFSDDGEMTPLYMVNGVQAMGEGSRSFTLVQPVGTKWRQFERDRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYS4</accession>
    <name>A0A5N6TYS4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_152758</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYS4"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="49"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8151404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="287" mass="32136" checksum="CD6D2FED2D13C528" modified="2020-04-22" version="1">MTGVNGGHGEDVHQPPAHIPPAPMEDYQFPELRLKSKMDDPEKTPLLLVACGSFSPITYLHLRMFEMAADYVKFSTNFEIIGGYLSPVSDAYRKAGLAAAEHRVAMCQLAVDQTSDWLMVDTWEPMQKAYQPTAVVLDHIDHEINTVRQGVEAADGTRKHVRIALLAGADLIHTMSTPGVWSEKDLDHILGKYGSFIVERSGTDIDEALAALQPWKDNIHVIQQLIQNDVSSTKIRLFLRREMSVRYLIPVPVIRYIEQHRLYEDDSTANNSTSDKGKGRQEPSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYV9</accession>
    <name>A0A5N6TYV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_171339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYV9"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025043165" description="FAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="478" mass="53633" checksum="C5C923ABC37E0CC3" modified="2020-04-22" version="1">MGKRPFKVIIVGGSISGLTLAHCLDRAGIDYVVLEKHHDIHPQLGASIVIFPNGGRILEQLGMFRQIEELSQKFSRIHSCFPGGFYYDNDAPKKIKDMFGLQFTILERRQVLQVLYSELRDKTRVHAGRNVAHISPTDSGVSVTTEDGTQYDGDLVVGADGVHSVVRSEMWRIADLQQPGLISQKEKSSMTVEYICIFGISNSIPGVKYWDHVIRYNSNVTLLVFPGTENGVFWLLIQRLDQKYTYPNVPRFGKEEAVARCESLADLAVWEEVRFGDIWEQRRTFHMTALEEGLLDRWNYGRMVCIGDSVSKITPNQGQGANTAIEAAAGLANVLHALTQEPNGERPSEGEITHLLEQFNRTQHRRLLGVHQAARLVTRLESFDGLANYIFARYVAPRCGDLTVAGIARVSTSGPVLDYIPLTERSGKYWTTVAARTTWKSNLAYPVTKALVNYGTVLFPIACLWLSYSVVAPRFLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ95</accession>
    <name>A0A5N6TZ95_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_171352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ95"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="501" mass="54855" checksum="E28B047DB48D2FDF" modified="2020-04-22" version="1">MADKQMSARDQPDPEKGRERETPIKQQLFPESDLSQGIVGWEGQMDSANPQNFPPRKKWGFLGLISAFTVVSPLASSMFSPAVSYMAADFHETDQTIVAFTVSICLLGYTFGPLILAPLSEIYGRRLILSLANWFFVAWQIGCALAPNIAALIVFRLLAGIGGSACITLGAGVIADLFPRDQRGMATAIWGVGPLLGPVAGPIMGGYIGEEIGWRWVYWILLIVGGVMQLGIEILNQETYAPVLIRWKTAKLSKELGRTDLRSAYELPHGDSSPAQQLRQGLVRPILLLLKSPIVFLLSTYMALVYGLLYLFFTTISSVFTTRYGFTTGLSGLAYLGIGVGFMLGLGIVAGTNDRIVVKLTARNGGHFEPEMRMPLMIFFACIIPISFFWYGWTVEKEVHWIAPIIGMMPFGLGMMGVYLPIQTYVIDCYPAYAASANATLTATRSLVGAVLPLAGPAMFEALGHGWGNSLLGFVALVFVPVPIAFTRWGKWIRERYPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZD6</accession>
    <name>A0A5N6TZD6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZD6"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32626" checksum="FA48DE294A090F3A" modified="2020-04-22" version="1">MNQLKYNSLICTYLLYTVHPILSYSSFTMSVYVITGVSKGIGFEFLSQISEDPKNLVIGLVREKAATEKKIAAELGDRTNIHIFHGDLTNYTSLKQAAADTTEIVGERGIDYLVANGALVPSLDAYGPIGALSDKVEELEAVSSQLLQTNVVGNIHLFHLFLPLVLKSKVKKVITISTGVADLDLTNDCEVDVGALYAASKAAMNVIVAKFNAQYKKDGVLFMSISPGLVEVGRYADCTPEEIQGLTGFMGKLITYAPHFKGPMTPEESVRHVRSTWEKASIEDGFGGAFVSHLGNKQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U061</accession>
    <name>A0A5N6U061_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U061"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="340" mass="37156" checksum="D76AF8605EC5E455" modified="2020-04-22" version="1">MSFNASQVDLTTARKEDVLCFLALSENTYNGHLGARISSIFVILIVSSAFTFFPVVAKRLPSWKIPHSIYTFARYFGTGVIVATAFIHLLDPAYKRIGPKTCIGESGHWADYSWCAAIVLASIVIIFLLDLAAEVYVEWKYDISKPEDTTHTFTTQKPSPPSSPHLPSPSTDETNAERSFRQQIAAFLILEFGIIFHSIIIGLNLGVTGPEFATLYPVLVFHQSFEGLGIGARMSAIPFGQHTLLPWILCSLYGLTTPIAIAIGLGLRNTYNPGSKTALIVQGVLNAVSAGVLIYSGLVELLARDFLFDPCRTKRRGKLLVMVAWVCLGAGVMALIGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0D2</accession>
    <name>A0A5N6U0D2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose-proton symport</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0D2"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19994" checksum="22CF3E796038A764" modified="2020-04-22" version="1">MPELTPFWNQPSHPDQLEVVKGDQPYQSSARSLISLPAGALFAKITTATPENSDTYSSVAVGKNARIELNSDLVYCNHSCSPSLVFDMTRFEVRVSDDRALAVGDELSFFYPSTEWTMVQPFKCQCGAGSQCIGWIAGASHIPNSVLHRYWLNDHVRQLLDEQSGTTVGWPFHCEQRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0H1</accession>
    <name>A0A5N6U0H1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_138249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0H1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025055603" description="glucose oxidase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8152085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="581" mass="63654" checksum="67E332C6F381D3B1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0L2</accession>
    <name>A0A5N6U0L2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRM8</name>
        <name evidence="11" type="ORF">BDV25DRAFT_138183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="9"/>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0L2"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="36112" checksum="D3916284EE6BA6EA" modified="2020-04-22" version="1">MSAPPPKRQKREQYRKKAAAAASKDAPGHIKLPQKKFYRQRAHANPFSDHQLIYPLSPAHMDWSTHYPAFVDSAEQTNLAGARKLDRDVEVVDIGCGFGGLLVGLAPVLPETLMVGMEIRTQVTEYLTTRIQALRTQQRKLKDSESPAPVPDAADASADADADGDSETPAGVIAGGYQNISALRANTMKFFPNFFGRRQLSKIFICFPDPHFKARKHKARIISENLNAEYAYALRPGGMLYTITDVEEYHHWILRHFREEGDQPSEGGVKDLFERVTEEELERDPCVAVMKEATEEGKKVTRNKGNKYVAVFRRKADPEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U185</accession>
    <name>A0A5N6U185_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_138354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U185"/>
    <dbReference type="OrthoDB" id="4497263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="36978" checksum="3C69308A64DF388D" modified="2020-04-22" version="1">MSILYTAETNSGSVTSFIPLTTVWPFSSACRSYFRKNGPSLMAYDPGYGLEIDTKVICAPPAVTTWWEQRKLGRGSHHTAVSIGPLTCPEDFSTVITSIKDRTSTLAMCCPSEYYLADTVPGQIKGRCLSDVSSGMTITYASTPHGQTTAWTTVTTTLSKSSTVGAIAVIGWNIEMSISATTLTASATSTSVIVSIPTSIATSIQTSIAASTQTYIITSVPTPITTSTKASTKTSSSVQTSTLQLTSDTPNPASNTPSAPDSDLTTGVKAGIGIGVGVGVLGVVALVVALYLYINRHHSSPAPVPALEPQPSPMFRTNWQQPSGPVEAPVTKRRVQQEPAELMGPLVKSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1B3</accession>
    <name>A0A5N6U1B3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_79270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1B3"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="34044" checksum="F51934AB6517D8F3" modified="2020-04-22" version="1">MNAIRQIQSLNKRELENAVPPEASWHADYRDTAYVYVGGLPYDLSEGDIVTIFSQYGEPVHVNLVRDKETGKSRGFAFLKYEDQRSTDLAVDNLGGATVLGRMLRVDHVRYKRRDDEEEGDNVAKLMGDANDAGGDTDDERRKRKKRRGSEDEPRRPLLKEEKELQELMVNHDDEDPMKEYLIQEKKEEISQALENYTQKSSRRRDSSRDRSSRHHRHSRHHRRRHEDRSRSRERSYRHRRSRSREGRSHRDRSPSRRERVYRDRTPVGSRSPEPKRSRDKDDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1M4</accession>
    <name>A0A5N6U1M4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_76758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
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</entry>
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    <accession>A0A5N6U1V9</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">BDV25DRAFT_65645</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="835" mass="90783" checksum="3DBA25BD36F42800" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Mortensen U.H."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF16">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="142"/>
        </location>
    </feature>
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        <location>
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            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="99"/>
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    </feature>
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            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="535" mass="59682" checksum="3D589A0A0EC98090" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2D5</accession>
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        <submittedName>
            <fullName evidence="2">TIP-1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_170068</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2D5"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1420:FF:000001">
        <property type="entry name" value="RINT-1 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="818" mass="91951" checksum="D464F946AEBAFC55" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3H5</accession>
    <name>A0A5N6U3H5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_150021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3H5"/>
    <dbReference type="OrthoDB" id="3446116at2759"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
        <property type="term" value="F:S-(hydroxymethyl)glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="191" mass="20585" checksum="0F9E1A60E25C8C81" modified="2020-04-22" version="1">MSFSLHPAVDNGLTKGDANFPGGNLYCLCPQNKVTVTLSSNVAHNHACGCSKCWKPSGALFSVVGVIPKDNLSVTANADKLHIIDPEAAIQRHACKQCGTHLFGRIEKDHPFKGLDFVHVELSDKKGWQEPQFAGFVSSIIEQGFSPNQMDAVRGKFKSVGLETYDALSPPLMDLIATFTAKKSGKLSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3M7</accession>
    <name>A0A5N6U3M7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_137130</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3M7"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024898218" description="chitinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="250"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8153225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1254" mass="133533" checksum="9DA80FCA11BDB84D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3R2</accession>
    <name>A0A5N6U3R2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_137123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3R2"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="241"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="406" mass="43741" checksum="FFE494EE36BE139B" modified="2020-04-22" version="1">MIDFTLSPTQHQIRQNAQSFADTHLQNAHTLYTQPSARERFRAIQPVYRRAVEAGLVQAQVPSEYNGLGYDLIDMALLTEELYTADVSVALTILGTGLGLSPLLLGGTDEQKRRFLAPFTNRTGVPLASLVHSEPGGTANAVSHGLATKAKKVDGGWAITGEKLWAANSGGWDDRGADIQCVTCSSDEGVMILLVTREDIAENATTAYKVLSHPETIGHKAVCGPHIRFDSFIAKHVIARGSGAQIIQGAFTASAALVGAMSVALMRKCFERTLRFAKTETRNGREPIINRQSVADLLVQMKMRCEAARALTWKACATLQSGGGDGETAHLAKIFASDSAVQCVVEGMNVVGVSAYQVQMQYGELLNDAVCLPVFDGGNVGVRRRELEARFKLDGYSPWAASFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U480</accession>
    <name>A0A5N6U480_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_169048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U480"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="7" id="KW-1207">Sterol metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="40278" checksum="009D38B6E7E13D45" modified="2020-04-22" version="1">MQSKLDNVRGIIQHIQNNSFDPSKARVENLVGAVPVPVGLAGPLHVILPGSTENIYAPLATSEATLVASCSRGCKALSRSGGVHFHVLSEGMSRAAVLRFNSPNEAFQFARELPNIEGELARIAESTGRFVRLQKITPHIIGSELHVHFNYTCGDAAGQNMVTIATQAICAWLLESPWRAKFKLKDYMIEGQMASDKKPSWANVKEPRGIAVVSWASLSDTVCQDVLGLTTKKLYQGIRTLQEGGIRNGQHGSNVNTANMLAAIFIATGQDAGSVAEASWSQLTPDYDTESKVLKLSLYFPSLPVGVVGGGTSLDAQRDALNLLGCAEPGNGNKGRLAGLIASFALGLDISTVAALSNGTFARSHQQFARGPKETAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4J0</accession>
    <name>A0A5N6U4J0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4J0"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="32209" checksum="4999FFCF6DD9D9C2" modified="2020-04-22" version="1">MTSIHFHISNEVTLHARLSRPAISHKKPLLVFLHYWGGSSSTWYKLTSPGLPTSLISTHPTLACDLRGWGKSTGPSVDDGTAYLASTMAKDIATALQQLSSDNATKNLLDDGFIFVAHSMGAKVALATLPALPSNLLESLKGFVLVAPAPPTALSLPPQMKEQQKMAYSNEESVRWTVENVLANPAHLDDRDIEQIVRDSLAGNKSAKEAWPGYGMQEDISGGVKKVLTSVSKGKLRASILVGGLDVVEPREQVDRHVRLFLEENGVETSLQYVANGKHLLPLEYPEAVYKEIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4M7</accession>
    <name>A0A5N6U4M7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4M7"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="37568" checksum="07C3527EB9FB0C9D" modified="2020-04-22" version="1">MTQYTNITPSSATALTTSILTAHGIPSAHAALIAHALTLADLRGVDTHGINRLPGYVTRVQAGLVSANPELRFTQRTPVIASLDARNSFGFVAGCLAVDRCIEMAGVYGLGMASVKHSNHYGMGATYVLRAVERGFACLAYTNASKAMPPWGGKEALLGTSPFAVGVPGGREGDFVLDMSPCVAARGKIRKAARRGEPIPEGYALDKSGRATTDPVAALDGGVVLPIAGPKGSGLALMMDIFAGVMSGAGFAGGVADQYVEMGRAQDVGHWFLVFRPEVFLDGGLEEFRERMDVLFRAVRGVEKAEGVERVFVSGEMEAEVELRRRSEGIPLTAAEVEALHLLAGRAGVKERLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U548</accession>
    <name>A0A5N6U548_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U548"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="159" mass="15948" checksum="855E345AAEB00CF7" modified="2020-04-22" version="1">MSATTSTPSKPTCGSSAQYEIPVKDASCAVPNTDNYPKLLESCCQGAPVSKYDNDCAIYCLAAGQSVQDLTDCLYDAKVDWGDVWCFGDTNATATASVSLVKATATATSTASGKGKSASSTKSGAAEATGSNGAVSMGVGRMAMGAVFAGLVMSLVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5E1</accession>
    <name>A0A5N6U5E1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF1212-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_21995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5E1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="359"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="638"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="87398" checksum="021DB20AD165B9EA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5Z8</accession>
    <name>A0A5N6U5Z8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5Z8"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26540" checksum="18D973B80D314FBF" modified="2020-04-22" version="1">MDSVKGKVYAITGLSGIGLSVATHLYNAGATLSLADISPAALTTALTTLSADNSNNNNNNPRILTTKVDISSATSVNEWISATVARFGRLDGAANMAGMIGNQHGTGTLLEQDDDEWDRLLRVNLTGTMYCVRAEVRAMLGCGGVGSIVNATSIQGVRGFGLHVGYSASKHGVVGLTRSVAKEVGPGIRVNAVAPGSIQTPLLDQAVAIQGKLTQPPTIIPRNGTPDEVAQTVVFLLSDASSFTTGSVLHVDGGWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U604</accession>
    <name>A0A5N6U604_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VID27 cytoplasmic protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_148472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U604"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="424"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="800" mass="90570" checksum="121848CFA5B1A1C2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6C7</accession>
    <name>A0A5N6U6C7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6C7"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF1">
        <property type="entry name" value="OS08G0476300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26590" checksum="C2007D8374DD5FA6" modified="2020-04-22" version="1">MTVSENRNIAIVGVGSLMSKSLAIWLASLGWNIALVSRSEKSLSAIADEVRHAQKGKSGKVVYRSADAGEPTILKAALDWCVQELGGKLDVLCYNAARVALSNIMDVTCDDLEQDFKVSAVGTLTSGQWFASGNANVDRVSDGEWPLLLVTGGLLDKQPEEYVASLSCAKAASQAVSRLFAKSLPQKANILVGMPLISGRVVSPGEEGYSQRFDADEIISAVFKPFFEDREKRSRGQEGWIVERVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6T8</accession>
    <name>A0A5N6U6T8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_136580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6T8"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="51178" checksum="008F878160E973DE" modified="2020-04-22" version="1">MSPSRLLPANGADGKPSEESPSRESLHVIDDRTGKYYQIPIFHNAINASEFKKIRAPENEDFAADQNESGIRVFDPGFTNTAVVESKITYVDGLKGSIQYRGYDLNDVVANNKRYMDTAYLLLWGHWPTAKEAGDFQQKLFDASHLDQAVLDAIRAFPSTGSTTSMIVAGLSAVQATQMDKVPAHMAKNLYMGNPALVDEQIIRLMGVLPVVSAVAYCHHTGREFHSPRADLTYIENFLYMTGHVQESTGLPDPRYVDYFERLWALVADHEMTCSTAALLQTASSLPDPFSCMISAISASYGPLHGGAIEFAYKDMAEIGGVQNCQAKIDRVKSGKERLFGYGHRVYKVTDPRSEHIQQVLRELKAEIDNDPILQVAFELNRIAQEDEYFVSRGLKPNADLYAAFTYGAMGFPPDFILPISTISRTQGLMAHWKEAMSARAPRIWRPSQIYTGKLNQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U700</accession>
    <name>A0A5N6U700_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M60-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U700"/>
    <dbReference type="OrthoDB" id="10260387at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1250">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.80">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
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        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051244">
        <property type="entry name" value="TCAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730">
        <property type="entry name" value="EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730:SF5">
        <property type="entry name" value="SI:CH211-210B2.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024953725" evidence="2">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="3">
        <location>
            <begin position="266"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="657" mass="74068" checksum="CF27F9ECE9300203" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7A8</accession>
    <name>A0A5N6U7A8_ASPAV</name>
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        <submittedName>
            <fullName evidence="17">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_148418</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7A8"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="443"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="600"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8153981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="744" mass="82562" checksum="61190B600A774129" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7D1</accession>
    <name>A0A5N6U7D1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_147472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="110" mass="12102" checksum="97AE38DB231EB4F9" modified="2020-04-22" version="1">MSITHLVLFKFKPGLDPEVVNDTCQRMLGLKDNCLHPTSQKPYIKTSSGGKDNSPEGIQNGITHAFVVEFANASDRDYYVNEDPAHLAFVKSLDGIIDKAQAVDFTDGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7G9</accession>
    <name>A0A5N6U7G9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7G9"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36628" checksum="7DA821E846D71B0E" modified="2020-04-22" version="1">MPSPTPNAFVRRARKIYTPLGFKKGYNFTLFFIFGGAWLGFTLARLQFLNFSIFCQEASPGECFYYKDLGYVGLYLHLGCILPGALLAFLQFIPAIRYKAIIIHRINGYIIILLVIASNIGALMIARHAFGGLISTQAAVGFLVILTTTAMAIAYYNIKRLQIEQHRAWMLRSFFYMGSIITVRIILITAAVIISKQPYFMSQPCDKIDYLLGEQETLQRYPVCGRYYNGSQPDQHVSVLANFNGYVDQIASALNANFGMALWLAVAMHGIGVEVYLQLTPRESNRLREVSYQRQLEAGFENPGRAGLTVDKIGDGELWVPGKTGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7T0</accession>
    <name>A0A5N6U7T0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_171480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7T0"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8154654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26678" checksum="6F582D8FB58CB5B2" modified="2020-04-22" version="1">MTPNPAQAGEAAPADAHIDHAASLQYWNSVPANTPAMLAMLGNYPWYTRIDLRGSKTFLSKVRRLIPGCATEGKLSHGVDCGAGVGRVTEGFLSSVCDTVDAVEPVEKFTQVIRDSALKQSGAVGDIYTVGLEGWVPDKKYDLVWTQFCVGHVTDAQLVEYFVRCREALTESGIVVVKENLSTDPNGLDMFDEEDSSVTRTDEKFREIFAKAGFGVVLSELQLGFPKNFKLLPVRFYALRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7W5</accession>
    <name>A0A5N6U7W5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_135617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7W5"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024792274" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="196" mass="21106" checksum="5E2C596DC7D782CF" modified="2020-04-22" version="1">MRIQLFGLALASLSTALATPLTTRADLLYPYATYRYWVNTGNFKEDPQDQLLVNKNGNLADETTGIVTFNIPSSASGHKCKLLFDLWARDVSTGSQSADVFTATKPTGASISAEGDAALKVLSKETAEVVVQSRDRHVGRIKAVIPGSAEWTMAYEGYPEFDCPAGQMVGFEFVGVGDAVAIRWDIGVTGPRVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U818</accession>
    <name>A0A5N6U818_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pinin/SDK/memA/ protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_147347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U818"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="35794" checksum="E92B5A9C5C4CF5A3" modified="2020-04-22" version="1">MAEGTLASAVALPEQDTLPPSPDTGLKRRNSVTEADPDTKRRRLSSQHEDNDDRTAAEPAQTSPGVTDRKPERKPGRQAGGREEERKRGQRLFGALLGTLSQRSNPAAQKRRADIERRQQDKLKLQDEEYGELKKKKREERSVIRKKEQRLYEEEAMRTRHANILAMAHFLKTKAEPALYYKPWQLRSDDEDIIQDQVEEAKATISREISEFESRYPPEEEESTKESNDDNKEEKHDQAPAPEADTQELKEISQETSDPVGAETNHVRGSEVARTDITPTNDNNVSMDNDHADVHRGAEDDGGEVVEDKEDTVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U824</accession>
    <name>A0A5N6U824_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U824"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000934">
        <property type="entry name" value="Allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="501" mass="55628" checksum="F274E006FAD4F53A" modified="2020-04-22" version="1">MGSAKDLETNVSPALSSTGSSERDENYEVYKQTRELEYTEEEAKRVLKKIDYRLMPFLFLIYLLQYLDKNSLNFSSVYGLKEGTHLKGQDYSWLGSIFYFGYLIAQWPAGLALQKLPIGRFLSITTIVWGGLLMTTPACYNFAGIAINRFLLGVTEAVVNPGFVLMMGIWYTSNEQPLRLEIYYCTNGIATMFGGLLGYAIGHITTGLPRWMYVFLIFGSVSLAIGIASLLFLPDLPSTAKFLTERERAIAVDRVSVNQQGVKNNHFKWYQVRQAAQDPKTWLLFIMAIGAQVPNSALTSFTSIIVKSFGFDTLGTQYLQIPGGAVQFLTLLLGGFVATKYSGKFHSRCACMIFANLVCIIGSGLLVGLPDSNKWGRLVALWLCYFQGLGFSMSLTIVSSNIAGSTKKQVTGALLFTGYCVGNIIGPQTFKSSEAPGYHSAYVAMLVGYAVKLTSITALYLYMYFENKRRDREAAETPDDGIKNGMLDQTEIDNKAFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U888</accession>
    <name>A0A5N6U888_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_147071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U888"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11890" checksum="81492AFB14BCFEBA" modified="2020-04-22" version="1">MNNLSIYPSTTRFFNATTPVLSSICSPGHGGRLVAIRNLHVVKYGRLVNENDGYASYALHLVGQELSIPTPRLYAMFQREDELYFVMEYIDSYYSFMAYTFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8H1</accession>
    <name>A0A5N6U8H1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_135545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8H1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="502" mass="56958" checksum="502EC34D181F1CCA" modified="2020-04-22" version="1">MDSHNEAVASIAAQVQQFHDRQQPFRIYHGSTNSTRESQHSASNTINTAHLNHVLSVDRDRKTITVEPNVPMDDLVHAALAEGLLPLVVMEFPGITAGGGFSGTSGESSSFRHGFFDATVNRIEIVLANGQVRSASQHTESEQELFWAAASAFGTMGVVTLLEIQCKEAKPYVSLTYHSTSSMADAMHVFKTTTAAPETEYLDGIIFSPTHIVICAGHLVDSPPPNTPIQRFTRPHDPWFYLHAQRTAKPTTHCIPVQDYLFRYDRGAFWTGRYAYSYFLTPFNRITRYLLDTFMHTRVMYHALHASGLSKQHIIQDVAIPYKHTPQFLTWLSDPQNFAAYPIWLCPLHHANGLMARGAESSPHTSLHTDNPDDDGDCLMNFGIWAPSRHGRNIPAFIAQNRRIESKVQELGGKKWLYAHAYYTEEEFWAIYDKPRYDRLRAKYGAAYLPDLYQKVRVHLIPGGEGGWVGWVKRAVWETWPVCGLYGVWRAWWGGEYYLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8W0</accession>
    <name>A0A5N6U8W0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8W0"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024937846" description="Six-hairpin glycosidase-like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="2">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="3">
        <location>
            <begin position="128"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="4">
        <location>
            <begin position="500"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="930" mass="102720" checksum="C0F90B7647F44E4A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8W1</accession>
    <name>A0A5N6U8W1_ASPAV</name>
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        <submittedName>
            <fullName evidence="11">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_135392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="366"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1583"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1237"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8155057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2398" mass="263499" checksum="37328658D4A03160" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9E5</accession>
    <name>A0A5N6U9E5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease/ribotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024917017" evidence="4">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="149" mass="16480" checksum="36D61B9D7410F861" modified="2020-04-22" version="1">MVSFKYLVALALGATPLASPTPLELDARAGQTYTCRKGEKNDGTLIGKVSQDKSIGYFREAKTTAGKSGYPMRFYNNEELAFGSGCRDKNAEIWELPVLDGGKRYDYQKSKKELNPGRMRVYYTKDLTFCGIGTKSNDDNSGPVHSCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9J7</accession>
    <name>A0A5N6U9J7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9J7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024867691" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35742" checksum="58E1B96372E09814" modified="2020-04-22" version="1">MRITHEPLVGLALLSKLTQALSPYAATCFPPPSGEKELVSGTFVSYRCSSWLQDSYYSGNHFQAATPETCAIACAGRSNQGPCAWYGGQCYEFDPGAPTTTLSQSIAIHIRKETQDYKADYEQCLIDKQTAHDQYEIDKQTAHDQCEADMKTAGDKCEADKQTADNKCEADKQIADNKCEADKQAAGNKCEADKKIAQNQCEAEKQAIRDQHQHGGAKALQDLDEFFASCQGGQRHQFTVSGRNWRAYCKTRVYVPNLSFTLEQGRVNTPSACMKRCTTRGATCKGYTLRPGGVCHTVNLPSSSSVLNVQNYIPDDRVSFVQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD14</accession>
    <name>A0A5N6TD14_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_134812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742592">
        <property type="protein sequence ID" value="KAE8144274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD14"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="478" mass="53489" checksum="5EEC4233114C2CEC" modified="2020-04-22" version="1">MSAPQANEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQVSRAAKMLAEEFGTASNIKSRVNRLSVLSAITSTQQRLKLYNKVPPNGLVVYCGEIITSEGKERKINIDFEPFKPINTSLYLCDNKFHTEALSELLESDQRFGFIVMDGNGALFGTLSGNTREIIQKLSVDLPKKHGRGGQSALRFSRLREEKRHNYVRKIAELAVQNFITNDKINVAGLILAGSADFKNDLNQSDMFDQRLQSKVIKVVDVSYGGENGFNQAIELASETLSNVKFVQEKKLIGKYFEEISQDTGKVCYGIDDTLKALELGAAETLIVYENLDITRWVLKDSNGSEVVVHSTKAQEENNRELFTDKETGVEMEVVDQTSFLEWLAESYKEFGATLEFVSDKSSEGNQFVKGFGGIGAILRYKVNFEQLADYDDEDEFYDESEDVWPEVPKVDLLTARPVNHERGSHGSTMASLVPTMHDVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD19</accession>
    <name>A0A5N6TD19_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742701">
        <property type="protein sequence ID" value="KAE8144177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD19"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="314"/>
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        </location>
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        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="100373" checksum="A11D3A7159667D95" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD65</accession>
    <name>A0A5N6TD65_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_167374</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="ML742651">
        <property type="protein sequence ID" value="KAE8144217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="221"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8144217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="355" mass="38980" checksum="00ADF4B56A5FED75" modified="2020-04-22" version="1">MSTSDHNGAPPVGQENINTDIVTLTRFLTEEQTKVREATGDFTLLCHALQFAFKSIAYYIRRASLINLTGLAGSSNTTGDDQKKLDVIGNDIFISAMRGSGKCRILVSEEEEEAIVFDEHPNARYAVVCDPIDGSSNLDAGVSVGTIFGIFKLPDSVLGPQNKVTPQELLRAGTEMVASGFTMYGASAQLVITMRDGGVNGFTLENSLGEFILTHPNMRLPTKRSIYSVNEGNSMYWDEWTNAYFHSLKFPGEGQKPYSARYIGSMVADAYRTLLYGGVFAYPADKKAPKGKLRILYECAPMAMLFENAGGLAVNSRCERLLEVVPESIHDKSGVFLGSKDEVQKIVDTFNKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDE0</accession>
    <name>A0A5N6TDE0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_145691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742548">
        <property type="protein sequence ID" value="KAE8144373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDE0"/>
    <dbReference type="OrthoDB" id="4526541at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="621"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="965" mass="108908" checksum="6D07133AE971D5F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE85</accession>
    <name>A0A5N6TE85_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742486">
        <property type="protein sequence ID" value="KAE8144560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE85"/>
    <dbReference type="OrthoDB" id="3912356at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55111" checksum="C3448446D8C91F44" modified="2020-04-22" version="1">MSAESPGERRGGFRAFFAGALRPKKSRQVLRKGYSASTPNLRAGLQSNDDVPEMPSLAPLQAHRLKYQEANQNKDAQLGESRDHTAILHAIGVGGLDPSDPNAQHYEVDNRPPGEPLIASLTPDLWAHVCEYLNPGERVSLAFSTKTLLSRLGPAPWIALRLPENNDSRADFLASQDRLYPHHLLCFPCGRFHRRTQEGREKLQPADVINPLFNCPNMRNAARPAPRHRITHGRVLHFTFYQLVMRASRFGPRYGIAPESLSRRWRRDGWSHHTRYHIHQGRLLMRVVSTCFANPSLTPSQQRLLLYSRDDYWPYFSVCAHWRDGELMNVCKCALSHIPAPRTTAGLQGLEHRAKDMYHGRAHNPNALASLCGKCRPMRRCPECPSEYLVEVKLTEDRSNANTMLFRHAIVVTRWSDLGDGRSPRLSREWAAINGSEGGEGYDSFAVMGKRSISGTFESAITDDTLPGQRIISMNPKGKKLGEAGNNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEV9</accession>
    <name>A0A5N6TEV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_165965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="ML742427">
        <property type="protein sequence ID" value="KAE8144836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEV9"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="84"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="573" mass="62097" checksum="92B448B4BFC51D57" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEW4</accession>
    <name>A0A5N6TEW4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylglycerol lysyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_81401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8144914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phospholipid homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PG_lysyltransferase"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
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    </dbReference>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Machida M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">IBT 18842</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFA3</accession>
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        <submittedName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="859" mass="95374" checksum="2293AACB8B077418" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFP9</accession>
    <name>A0A5N6TFP9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742378">
        <property type="protein sequence ID" value="KAE8145162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFP9"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="267"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138011" checksum="C4C81D073BFE198E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFR2</accession>
    <name>A0A5N6TFR2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_165690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="ML742409">
        <property type="protein sequence ID" value="KAE8144959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1033"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1335"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1340"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1062"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8144959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1361" mass="154054" checksum="C15693FA1D343931" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TFU7_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
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        <name evidence="7" type="ORF">BDV25DRAFT_170732</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="32"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="461" mass="50541" checksum="BF3854D8FE490340" modified="2020-04-22" version="1">MTGLWDMFHRWYRGTLYQAVILGLISFTQPGIWDALNGLGAGGLATPYFVNASNVITYVIMIVTCPIFAIAGNRFSLKWVLVAGTLGYVPYFAALYCNSVFGTQWFLLLGSVTCGFSAAALWVSEAAIAVGYPEIENRGTYIGIWMALNKLGSIIGNSIQLALNINNDHKGSISPRTYLVLIGLSCAGLPLALTIAPADKLIRKDGTKPTFSSTESKITLKEGLKGFWKATKQKYMLLLIPIFMTVRWSQTYQGNYLTEYFSVRGRTLAGFIQTVVGIVATILWGWLLDSKMLMKTKRRMAIVGWLAMLAVFVPQWVLNFVMQARLQGQSPTPSLDIHDPDYGKAIAAYCLFGVGSQASVVWTYWILGTYDIHVDVLAYTTGILRSVESLGFAIAFGIGASENVSLMTNLIVAFVVFWVSVPFTTYASCLVQESPGDSCPEGDLTTKVPTVTEEARDGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG56</accession>
    <name>A0A5N6TG56_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_133904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044249">
        <property type="entry name" value="XERICO-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="16"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="154" mass="17649" checksum="17714219DC55009C" modified="2020-04-22" version="1">MGLSSDSANIHHNNHMAIVLGVGLGVVTLIIMCLLLTIFVNRRERNPCSKKKKGSSDKLRKLDAVSPTRTLQEWRSKTKGPLLPSEEVDGQFVCVVCLESVLPSQEIRELKCLHVFHKECLEKWYLQDHYNCPLCHRAYYAQETHPSNDFVWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGX2</accession>
    <name>A0A5N6TGX2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_164908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742357">
        <property type="protein sequence ID" value="KAE8145341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGX2"/>
    <dbReference type="OrthoDB" id="5126814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="561" mass="61967" checksum="099FEF92BE7623FC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THI6</accession>
    <name>A0A5N6THI6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_61953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
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        <property type="protein sequence ID" value="KAE8145796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CC_SR_Kinase"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="686"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="168"/>
        </location>
    </feature>
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    </feature>
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        </location>
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            <end position="378"/>
        </location>
    </feature>
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            <end position="392"/>
        </location>
    </feature>
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            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="537"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="572"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116386" checksum="32EEFCA953BDA1C8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI35</accession>
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        <submittedName>
            <fullName evidence="7">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF41">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="6">
        <location>
            <begin position="245"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="414" mass="47025" checksum="834EEF07DF229639" modified="2020-04-22" version="1">MIALIRMLHLLNSEDAHQSHLAARHVAEEPLQGGDKAGFIAMGVIALFSFVSTLCLLGFLTYRFIFWRNYYKNPLADNQYIVLIYNLLLIDLQQATAFLICLHWVSKGTVYYPSAACVLQGWWVQVGDPGSGLFIMAIAMHTGAVVLRGRQLPYWTFVGCVIGLWAFIIVLGLIPVGMFGSKTFVISEAGWCWLSSDHETERLWVHYLWIFLSEFGTVVLYGIMFFYLRRRMQQAALLRQGHHDNLKRLNRVVIYMVIYPFVYLILSLPLAAGRMSTARHIAPSRAYFAVAGSLMALSGLVDVIVYTLTRRHLLLETEISTSDKMYAYSNSNAYQTHITTATRETKKMRVGSRLRRGLHTINDTINEGDSTEDLRKGEMEMAEMAHGVYQETTIEISHEPADPDEFHGHKRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIX5</accession>
    <name>A0A5N6TIX5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_162858</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742275">
        <property type="protein sequence ID" value="KAE8146267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIX5"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="293"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="450"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8146267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="605" mass="67487" checksum="920295AB44AA179C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJF9</accession>
    <name>A0A5N6TJF9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_162919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742277">
        <property type="protein sequence ID" value="KAE8146239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJF9"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000666">
        <property type="entry name" value="DNA repair and transcription protein (Xab2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000720">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="196"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="411"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="770"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8146239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="849" mass="98394" checksum="1829046994CAC815" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJT3</accession>
    <name>A0A5N6TJT3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742267">
        <property type="protein sequence ID" value="KAE8146369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJT3"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58522" checksum="13814402FF0ACC01" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJU7</accession>
    <name>A0A5N6TJU7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_169918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJU7"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="172" mass="19246" checksum="C6D4B421B6982CE6" modified="2020-04-22" version="1">MAPKEIEAKKRRTRSDYVFHQVYRTRWFDNDMYAHLNNTVYAMLFDSIVNSWLIAECGMDPFSINNKDTTGPGSSAAAQVGIMVNSYCDYFASVSFPDVLDLGLRVAKLGSSSVTYEVGVFKQGEENVKVVGGYTHVFVARETMRPTKAGMEERVRRGLEKLVKGGKEGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKK8</accession>
    <name>A0A5N6TKK8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_143286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKK8"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BCNT-C" evidence="5">
        <location>
            <begin position="272"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="351" mass="39395" checksum="B783FE36655284F8" modified="2020-04-22" version="1">MSAEAPTVPDIDLDDEQYDSAEDEDFQLDAAQDEGDVTSDSDEETTEPTKKKRKTGKKNSEEEDKDLDSGDEATIQKAKAKKEKKQKGKKASGDDEEDDDFDDEDGGPGGFVRTRAMKLRTQEERKPLAKIDGATIDVDALWAKMNAPDASVASNQSSIPKKDEAPLDKPKKDIEMRDSETTAAVDKQQPSQYPEEMVKIKRTYKFAGEWITEEKVVPKDSAEAKLHMANEKDVETVNAADVEKGKETVRIRRPFRKVSRFDPNPTGSIKKSWEKQPITEATGVENARGPKINTVEKSRLDWAAYVDQAGIKDELKTHSKAKEGYHGRMDFLDRVGAKEEEERRNLRLKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKM4</accession>
    <name>A0A5N6TKM4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_132535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742236">
        <property type="protein sequence ID" value="KAE8146908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKM4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="591" mass="67749" checksum="096FE04347119666" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKN4</accession>
    <name>A0A5N6TKN4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_43754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742236">
        <property type="protein sequence ID" value="KAE8146918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKN4"/>
    <dbReference type="OrthoDB" id="5407417at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16529" checksum="88F8EE2F72F5F8F4" modified="2020-04-22" version="1">MATTAETAVPPVQNVTPHVKPHEMSFPLPKAPHTTAHVHLTLKGTCTMVFLATSTLGESAGSVKPMGSFIYAMPDRTNPRNTLSTTLYTSANVEYTTRVAKILARRMQVPVYVGCSIDPVALELMVEEEMEGLTQIVDVIMKRWEEERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLD9</accession>
    <name>A0A5N6TLD9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742222">
        <property type="protein sequence ID" value="KAE8147162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLD9"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36750" checksum="31FFF552D31FA27A" modified="2020-04-22" version="1">MVASVGDFKLVGLAAGFSLGFGFLTVWNAMKQTMGIEKPYKSPYVILIWIEILSNLTIGVLGWLVLEGIIPAIAPVLAALLLCWAVEIHCLMQIIINRVYVVVDHKGTVDKVKWATAALITAINIAVFCLWIPAHMSPPVNDTYVRINRYWDPISKVLICIVDAILNVWFLRVVRQRLVRQNGLKKYGPLVRFNARVMVASVLMDVLLIGLMFLPNPLVYIQFHPVTYIVKLNIEMEMASLIRTVATDGSLEGFDEATGHHLSPFRPPSLYHHDDPEADHESFAHVPSAEMQQHDFEPEDMKILKTTSVRVVSNARPFVHGRLKHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLY5</accession>
    <name>A0A5N6TLY5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_161078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742225">
        <property type="protein sequence ID" value="KAE8147111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLY5"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8147111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="547" mass="60734" checksum="44B8C6C5FD17612F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM83</accession>
    <name>A0A5N6TM83_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, V0 complex, subunit E1/e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_160364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM83"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="75" mass="8485" checksum="08DA23709851E36A" modified="2020-04-22" version="1">MATGWGLIIGLVVIVIASVAAWIFSPKGENQTLWRSTLVLSFVSCYLMWAITFLAQWHPLITPKRSNMRPDRVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMC5</accession>
    <name>A0A5N6TMC5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_142716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742206">
        <property type="protein sequence ID" value="KAE8147467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMC5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="159" mass="18089" checksum="15EC1775236109B6" modified="2020-04-22" version="1">MVKQPGHNPTVEVHLDVDEGTSFTDSEDILCAMKRELMLVRGDYGPVRHAAVQPQKGNRPRILLRFTTAARTTRGVYADVERVIRAFEEILASRTVSRRLFRLPVMLDGWCFVDRVCFDGEKKGDSRGLEYAEFSVRSAGYESIEDFCSKVKLDSPVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMM2</accession>
    <name>A0A5N6TMM2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_142586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMM2"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8147613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="566" mass="61619" checksum="07B96C3079B49272" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMN5</accession>
    <name>A0A5N6TMN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_159933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742198">
        <property type="protein sequence ID" value="KAE8147626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMN5"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="33144" checksum="6ACE306C83E6776C" modified="2020-04-22" version="1">MGGKSATKAAYFEKLKSLLDSYKTVFIVGVDNVSSQQMHEIRLSLRGEAVVLMGKNTMVRRAIKGFVTENPEYERLLPHVKGNVGFIFTNGDLKATKEKILANRVAAPARAGAIAPADVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAAAKVGPSEATLLNMLNISPFTYGMTISQVYDDGQCFGADILDIEESKLLESFSVAIQTITAVSLAANFPTLPSVMHSLVNSYKKVLAVAVTTEISWPEIEQLKDRIANPDAYASAAPAAAAPAAGGAAAAEEKQEEEEESDDDMGLGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNB8</accession>
    <name>A0A5N6TNB8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_159503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNB8"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF11">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="34651" checksum="6D3FC354A9D73C1F" modified="2020-04-22" version="1">MKTLLDVVKDCDNFPYPEDTDQNTLWKFYLPNDPRPHGLLTDAVVAQMPWTTDFQILPEAKQIRLLQPPTENWEERCSALIEQQVEAARSANAFPDLGLRRGEEFPIVGARFAVGIDRAAFSLFGTIGRGVHLTAYTGSGAEMRIWVPRRNYNKAKYPGMLDNSVAGGMASGERPLECLVREAQEEAGLSEEMIRAGARAAGTVTWITVSDERAGGHLGLINPGVLYVYDLEVSPEMVFTPVDGELCEFRLRRVEEVKKALLAGEFKPASANVMIDFFVRHGLITAEDEEDYEDIVARLHRKLPLPTSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNG4</accession>
    <name>A0A5N6TNG4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_159470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742188">
        <property type="protein sequence ID" value="KAE8147840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNG4"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="389" mass="43276" checksum="0BE22A18E2608E08" modified="2020-04-22" version="1">MAASMHPTGSLLPRQVEESPPDSRAPHILTIVGALTGFSGLLVLLRCYVRLFILRKFMSEDGVIVAAVLCAFGVLACFVGESHYGVGRFSKHIGFEDLQKLSEWMYYHAIIIVLGISLVKVSLALFLLRFAAQNKVLWRVIIGALVFLIVFTIACILTLILQCIPVEAAWNFALKESARCYSMDTYLAIGEFNSAINILTDFVFATLPVFMFSRIQVNKRTRITLMGILSLGYFACAAGIVKTVLQSKIFNESDPYRDCQYLIWNCVELNVGILAASFPTIKPLVKSLIGTTLNVTSGGRYSKRNGPSYPHSSYAMHSLRHNRTANEDGKYTVQVGTSERDRESEEGSEENSNPRTSLSRILQTTEIIVHCEEGVDVGMWPKREIGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNH7</accession>
    <name>A0A5N6TNH7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topoisomerase II-associated protein PAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_159302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNH7"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="843"/>
        </location>
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            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="846" mass="93764" checksum="A60CEB7AB919831D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNQ2</accession>
    <name>A0A5N6TNQ2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_25142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8147940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024855537" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAE8147940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="274" mass="29656" checksum="81D55A7D99A6AA01" modified="2020-04-22" version="1">MYILHRFSVFSLILFFATNAPGVSSALTVTIPPSSLLPNPNVLSASTQATLTSLPSSAWLKDGNSDSYSLTAPLTRSATFVFQKFESTEEPESYLLDIRSAEYIFTSYRVDISADGTIMGIWETFRGNPWDNRGVEKFVADASTTNAVKSTDVAIEAKVMARRSFYEERSKFSPLTLFKNPMILLALVALGFTFGMPKLMENMDPEMRAEFEKHSRASPISGATRSAMAGGGAPGNFDFAGWMAGAQPRPAGSESPVSQGATTGREGGSARKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TP18_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_168677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01522">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="207"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="409" mass="46554" checksum="F8A49F83FB409408" modified="2020-04-22" version="1">MSPFIFLLGLVSARTLLHLSFLQSPQSTVPITIDSFPDPQKNDLGFWHGALENLPVTYSPSSVTLYPSDPDQIYHTELSPAQCFDLTPFQTWYLHITLTGAPHFSVSLNQNNIFCTPRRNPYPETWDSLDAARYSIRNASGTEIYMPLSHFHIDLSRVVSVSLGGFYQPYTPVKVSKIELVPTPPGNFPIPPKLRNGVLRLACTRPGSFAFGIDDGLPWLAREVMEILESEGVLATFFVVGRGLRDRRTGFGEFYRKMIARGHQIALHSDLHRKMEALEDKDIDDDIRSNIATFQSILSIKSKYFRPPYGTIGARTRQHLAKHITDPQIINWSVDIEDWMWADSETPERQLDAFYRDVERGGNLAVMHYLSPSTVGYFREIIKFVKARNLTIMRIDQCLEDRDAPLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPK5</accession>
    <name>A0A5N6TPK5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_131532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPK5"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="491" mass="55259" checksum="E4738AC12C328621" modified="2020-04-22" version="1">MAIAPLSRTRGPNPTISFEEGYDHDYSNDPQGSNSDSSSPPGPTEHIETMGAHFLDPFQTYPWRHSPEVANASQAYCTSILWPTLTPGAKRTDVSALNWFPLMMSEPTLMTAITFGSLSHQRVQWVNKWIPDGAFRDREQQLLRVCEMETIELINQEMKKPGRAISNAVILSVMCMAHNATDISEERQYRPSPFSAPMRRLQWIDVYGSLRPNLVHVHGLITMINMRGGLDAIDLPGLAPVVSLSDVVTSTAYLTPPVFPFYPLQTSRKNVTLQEMLGYSLADAEQQYGRLRQIGFTTELMEVFYAMNLYMSYVDSHLKGEREKPDYSLLADQRNFVQYQLLSLPAASQLDGFTGYQRRHEVIYEACRLAGYIYGAGVVFPLPPQSTPLAKLASLLRGVLESPDCLTIWDQPHARVTLLWVLTLGAIASEGTTDRDWYVSLLNRTAQHSHITCWADLRAIVILLPWFDAACDDAGNLLWLEIERLVTRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPV0</accession>
    <name>A0A5N6TPV0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_20142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742166">
        <property type="protein sequence ID" value="KAE8148310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPV0"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34541" checksum="916AA83D57A90B30" modified="2020-04-22" version="1">MFYFPRNWRHHNLFYILMAIEFPFTVVILTFTGIASHDLYRTKLWQDGADNGFNSSPDEVVYAAANYRPYKVPMVWGSFITDYNLVLGVLSVFMLITKIPVHVLRIFYPPLSVFVHIGLFILYIVSAAYQAGSDTSDPRHPQSGPPWYITKSCNVASNKEVIGYCKQAKALFGFTIIIIVIYFVEAVVSIHSCFLTKEEKAEHDERREEKRTMKEYEDMVLKTPRAFPMSPTAPPAESTQGTPTMSSRSPTFSKSGYGMSDLPLRDHFSTPNPRPPTQQESAETLTSGNQSQIYFPPPPKKAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ52</accession>
    <name>A0A5N6TQ52_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742168">
        <property type="protein sequence ID" value="KAE8148251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ52"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70685" checksum="DA7A77F664330F6C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ97</accession>
    <name>A0A5N6TQ97_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_158091</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="ML742156">
        <property type="protein sequence ID" value="KAE8148533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ97"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8148533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="395" mass="44840" checksum="B40CF866C85CC5CD" modified="2020-04-22" version="1">MGIKHLYQVISENAPDAIKAGDIKNHFGRKVAIHASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEDIEKFSRRTVRVTREHNAECKRLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRALEGLDMDRQQFIDLCILLGCDYLEPIPKVGPNTALKLIKEFGSLEKVIEHMESDPKKKYVIPEDWPYQDARELFIHPDVRDASHPECDFKWEAPDIEGLIEFLVKDKGFNEDRVRNGAARLQKTLKTAQQSRLEGFFKPVAKTDEEKANLKRKHDEKLQEQKKRKKEEAKAKKEAKARPRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQG5</accession>
    <name>A0A5N6TQG5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQG5"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35854" checksum="405C91C51D2F888F" modified="2020-04-22" version="1">MNLHLNVPRCNASFRTTSFRNSVGLTQFNRSLSSLTRRLFKLPSPPPHPSPHHYDLKSFLAYAEKSSLSLTTTSYVGTHYEYTVQQTLRNVAFSLHRVGGRSDAGIDLVGTWHLPGHEHALRAIVQCKSFKTKLGPNIVRELEGTFHQAPVGWRTGEHKLGVLVSPREATKGVREALARSTFPLMWMMVERGGVLRQVLWNGRAERQLGLVGLGVEMRYSGAEVEGVTLTWDGEEVPHMDAVEGRMAEVQDRWMRLWGIKLESEEEREGLVDAVQGLVPGEKPLLFAEECSTLSGEERARVLQAWKRDVDMRLLNSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQN2</accession>
    <name>A0A5N6TQN2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Decapping enzyme Dcp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_157988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742154">
        <property type="protein sequence ID" value="KAE8148584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQN2"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000444">
        <property type="entry name" value="Decapping enzyme Dcp1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35952" checksum="CC889684F383A68F" modified="2020-04-22" version="1">MSTRRPRRPNNNNNNYQYRHNNPQPSDYESDYQYYFSDTPQIQEQQAAHMPPPPIRSNEELNIAVLRRHNPTITSILSLAPYAVIYIFSPTTRQWEKSGVEGSLFVCQLSQGALGEERYSVFVLNRRGLNNFDIPLTDGDNVEITEEYVILKVDNDAGLDGSPVNGKTANNSDLRIYGLWIYSEPPPNSTAETRTINAQVIRECAVHAGQSLKLARERLEASRQNGLHAAAAAAASTAPPVEEVQASVPMGRQVSLRDLFGQQRAQDDAWSTRAHHLGPHDWPHPAMGPPMMDPQPQPPPQQDVLGDLFRRAGLAYQGGHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR21</accession>
    <name>A0A5N6TR21_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_11189</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR21"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8148808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="36182" checksum="127F5D3418C8400A" modified="2020-04-22" version="1">MRIRIRGPAGQSTVALDDSATAENLRTQITDKTGLTSYDVKYGYPNLKRFALDELQPNQKLVELGIDLDGEQLLVTKKDGSLQANPSHAEGSIYTPQQPSPQANNNAISDSDNPPEIPSPEHTGTFVLRIMPDDNSCLFRAVSSALMGGMDAMNELRSIVAQAIQGNLDVYSEVVLEKKPDDYCRWIQNEDSWGGAIELSILSKHFDIEICSIDVQTLRIDRFNEGSPTRCVLVYSGIHYDTVALSPSDPPFTQAHAPPEFDTKVFDAADHLVLERALELCRILQSKHYYTDTAGFRVRCNACGGVYTGEKGATQHAVQTGHYDFGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR23</accession>
    <name>A0A5N6TR23_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SsDNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_157997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742154">
        <property type="protein sequence ID" value="KAE8148589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR23"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16722" checksum="49BA0130561FA453" modified="2020-04-22" version="1">MSAFASSLRPIMGVAPRGALSTRSFSSSPAHSVARMILTGRLVNQPEMTATANGQDVIKYTLASNHGSKSSQKASFFKISNFEQNEHSRQFLLGLPKGTLVYFEGDAAMRQWEDAEGKNRTALSLVQRRIEILRRPYTDEKASEHSGESESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRJ5</accession>
    <name>A0A5N6TRJ5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle 9 kDa protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_157215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742140">
        <property type="protein sequence ID" value="KAE8148955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRJ5"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="148" mass="15305" checksum="B0A8D493C0C71B98" modified="2020-04-22" version="1">MPYLPTSQAYLEQSALLLEAYPNDTRITTKYNFPSQKPAKQSPPDTPSQTPIASLTLKTYNPTSGICLKYRTNKGAEVGRLITSLGKLAGGANVAALGLSNAAPVAQTGDVEMADAPEEGGSAPVSAAAKTEGNKAGKGRKKGGKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRJ9</accession>
    <name>A0A5N6TRJ9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_8357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742139">
        <property type="protein sequence ID" value="KAE8148986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRJ9"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000035">
        <property type="entry name" value="TrmH family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="486" mass="53757" checksum="77D2BAC86565E6A7" modified="2020-04-22" version="1">MSRALLSPFQRIYPSIHLNHVRHASINSAIGRGIRKTRGLEGASSSQNSLDIDYERPQHGKRDYRPHKGEKYNREPKGTFDEDEFIKTGKFRALPRVHQRPQNSKPFTKNENVGQRERGFRDESNEKRRPRRTEEPKHHRGTNTMPERVKENVRVPDAIPYTTPASEFIYGSSAVEAAMRCTRRRLYKLYLYQAAGEELSPAKVSLRKLALLNNIQVKMAFAGWDRLMDKMSAGRPHNGCILEASPLPRLPVRSLKTVASIDDDTFGVELGAQSREEAAINGTDNRIEIHRFQERKRYPVVLLVDGIVDPGNLGAIIRSAYYLGVDAVVFAGRNSAPLSPVTIKASAGAAENMTLFEVNNEVDFIQRSKANGWKFYAADAPGPASTYVDSLSPPESHDATNGGHGSSSSPCVIMMGSESSGLSHHMKTHADSIVSIPGARLNTPLGVESDPSRVDSLNVSVAAALLMEMFLRVPLAVADVPPKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRY5</accession>
    <name>A0A5N6TRY5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742137">
        <property type="protein sequence ID" value="KAE8149047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRY5"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="175" mass="18920" checksum="4A3926F59FB938C3" modified="2020-04-22" version="1">MASLFSADNAPQLGVALLRVSPLVISSASLMFSWAQDISLGAFLHPSLRTDPTHPSGKILPRFLPAFMKPGIWGIGLTYPPATVLCLVNGFSGQSSEIRHLYFAGAFFSIAHFCWGPSMFAILRRIQDPTTAGVPNESALETWLPRHHSRTLLVNVPAFLCIFAATVATIAEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS00</accession>
    <name>A0A5N6TS00_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_168076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS00"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="78"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="54562" checksum="9C660FE0FDBC6611" modified="2020-04-22" version="1">MAATVPTYLSVSGATLAQAHSSFELDNFNITTALKNYSINISTIPAQQGSEYPSRATACQTACNTLKTLYSTDKVLVHGVNPYTNFTNSFWSAQQAEVHPHCVFKPSSNRDVAITVLLSRLTSCPFQGSSNSPGGITIWFKNLSEVTLNEDQSVASIGPGNTWGKVYRALEPYGLAVVGGRLASIGVGGLITGGGISFHSNLYGWALDNVESYEVVTASGQIVIASVTQHPDLYWGLRGGGNNLGLVTKFNLYTIPFVNAFIKAARAAPSDGKAQQWVVYAPVQGTNIASTELTYAEDIADPAIFAPYMNITALSDTRKSTSLAQLCEEIDAGSPNGLREMYWPIATHLDQSFALWVARRFFEAVPRIANVSGAQPGLGQQAITEPILANMTKAGGNALGLDASRGPLLLMHLTCWWQHAGDDAAISSFMHDFWETVQVEAEKRGIAHRYIYMNYASQFQNVIAGYGVESNARLRDVATTYDPHGVFQKLQPGYFKLEGSPVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS96</accession>
    <name>A0A5N6TS96_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_156709</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS96"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="513" mass="59104" checksum="FB44252BBFA8BBE4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV7</accession>
    <name>A0A5N6TSV7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_140825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSV7"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="829" mass="92162" checksum="CDFD7ADA722DBC03" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSY0</accession>
    <name>A0A5N6TSY0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10546" checksum="38EFFA4CAA2FAF13" modified="2020-04-22" version="1">MVHKVLFWGGFGIAVRLWQLGIEMRPILAKESLWVYPLFAGVGSSFGYWLQGVEDRQLKILAQRREAILEKRQRRDQGTLSKVEEAGSLAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSZ1</accession>
    <name>A0A5N6TSZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 11">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_2410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 11"/>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSZ1"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF31">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="13">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="331"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8149476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="409" mass="44621" checksum="AB1C9FC8D03EFB58" modified="2020-04-22" version="1">MPSDKKPHTVAVIGSGNWGSTIAKILAENTASHPELFTPKVQMWVFEEQIQIPSDSPHYKRYGDKSQNLTEVINEVHENIKYLPGIKLPENVVANPDLGDAVKDATILVFNLPHQFIEKTLSQMQGKCLPYARAISCVKGVDVSDGTVTLFSELIMEKLGIYCGSLSGANIAPEVAAEKFSETTIGYDAPPMDLKAEDGSPSENRIKVDEQRQAKTKPTSVKLKRVPKELVTVDGELLRTLFGRPYFHVNVLQDVAGVALSGALKNVVALASGFVAGKEWGENGKAAVIRVGILEMVKFGRTWFPRSVDEKTFTEESAGIADLVASCSAGRNFRCAKHAVEKGVSVDEIEQTEMNGQKLQGTSTARSVHEFLEKHGKVDDFPLFSAVYGILEGSTSVDSLPKLLDKRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT31</accession>
    <name>A0A5N6TT31_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_125271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149518.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <name>A0A5N6TTC2_ASPAV</name>
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    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
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    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="322"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <position position="351"/>
        </location>
        <ligand>
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        </ligand>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="738" mass="80630" checksum="99F8640C974D65A2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTN7</accession>
    <name>A0A5N6TTN7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5024905953" description="Secreted protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8182" checksum="D6F0EAA5C705F5A9" modified="2020-04-22" version="1">MFFARISANCCRFSRSRFRILMVLCMWVCSPEGLSCLVSSGCVVKSVQDGLDISMRQAPQCLCSLLDQQWGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU83</accession>
    <name>A0A5N6TU83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="10">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_155388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="10"/>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU83"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024829989" description="AA9 family lytic polysaccharide monooxygenase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8149935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="318" mass="34186" checksum="E1D60239286A7412" modified="2020-04-22" version="1">MKATLSALSLFASLVPLVSGHYVFSKLIVDGEKSQDFEYIRKNSNGYMPTLASDILNDDFRCNQGSMDSASNTKVYTVAPGTEIGFELAYSAVMKHPGPLQIYMSKAPGDVKSYDGSGEWFKVYQEGVCEDISDGLEDTDWCTWGKNSASFNVPKNTPPGQYLVRVEHIGLHRGMSGNAEFYFTCAQIEVTGSGSGSPGPTVSIPGVYKPEDSNIHFNIYTHPTSYELPGPAVWSDNASVEASQSAVYQHKEMTKSTAPTSFATVAKSTTASVPLTTGGSKGSIKRFAQCGGEGWSGSGSCESGTTCRAWNTYYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUJ7</accession>
    <name>A0A5N6TUJ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_155206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUJ7"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="27047" checksum="78A64F9B2A9E67BD" modified="2020-04-22" version="1">MSPRTFIIRHGETEWSLNGRHTGITDLPLTSNGEKRIKATGKALVGNDRLIAPRKLVHVYVSPRMRAQRTLELLEIGCRERLPWNEARRDESEEPIRTEAKVEVTEAVREWDYGDYEGLTSKQIREERKRRGEGGWDIWRDGCPGGESPEDVVRRLDALIADIREKYHKPCFDGKTEQGDVLIVAHGHILRAFAMRWTGKPLTETSLILEAGGVGTLSYEHRNIEEPAIILGGGFVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUU5</accession>
    <name>A0A5N6TUU5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_140122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUU5"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="45489" checksum="29E721A33B019C29" modified="2020-04-22" version="1">MTGKSILSVNAGSSSVKITFYTFENPPKVVANAQVSGITAPPATLKYTRGSSNHKEQLKESLSTPQDAFKFLLQRCFSDSNLSEVASADDLAFICHRVVHGGDYKSSVVITEDTYHHLEKLEDLAPLHNFSALEIIRLCREELPSVKSVTFFDSAFHQSLPDYVKTYPINQKVAKANGLRKYGFHGISYSFILRSVAQFLSKPVEDTNIIAMHIGSGASICAIKQGKSVDTSMGLTPLAGLPGATRSGSIDPSLVFHYTNEAGKLSPASTKEMHISTAEEILNKKSGWKALTGTTDFSQIAVEDPPSKEHKLAFEIVVDRLLGFIGNYFVKLDGQVDALVFAGGIGEKSALLRKTVVEKSRCLGVAIDASANDKGPSDDQTVADISKAGTKGPRVVICQTDEQFEMAYNCVLTHNDDTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV43</accession>
    <name>A0A5N6TV43_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_154730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV43"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025009161" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="323" mass="36255" checksum="FE39C342616AE9E9" modified="2020-04-22" version="1">MHVLSLLSLPLLVAATPLQFSRSRPQASELAPLPLVIWHGLGDDFQRDGLKTVAALAEKTNPGTYVHLIHLADSGAGDRQATFLGNVSEQVAEVCDQLSSDRILSTAPAINALGFSQGGQFLRGYIERCNSPPVRNLVTFGSQHNGIAEFQECGWSDWICRGAEALLRAGRWSQFVQSRFVPAQYFRDPADLGSYLEHSNFLADVNNERESKNETYKENLSRLNRFAMYLFEEDQMVHPKESAWFGELDASSGDVVQLRDREIYKEDWLGLKGLDEQGKLEFKTTPGRHMEISEELLEGVFKEYFGPIEVDVPVQNSLVKQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW15</accession>
    <name>A0A5N6TW15_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_139735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW15"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="198" mass="22035" checksum="D1E9409589166FC7" modified="2020-04-22" version="1">MAQQQQNDNVMRRKLVIIGDGACGKTSLLSVFTLGYFPTVPTVFENYVTDCRVDGRSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDTPDSLENVKHKWIEEANERCPGVPIILVGLKKDLREDPLAVEEMRKKSLKFVTSKEGSDISTQIGARKYLECSSLTGEGVDDVFEAATRAALLTFDKRKSSCCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWE8</accession>
    <name>A0A5N6TWE8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_129339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWE8"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000086">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000126">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="408"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="654" mass="72935" checksum="E0365BB697ABE07B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWU4</accession>
    <name>A0A5N6TWU4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_154143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWU4"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="102"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="513" mass="55214" checksum="0D103F6D70E76973" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXE1</accession>
    <name>A0A5N6TXE1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXE1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="460" mass="51262" checksum="DFEBFDB2CE0E198A" modified="2020-04-22" version="1">MLAGFKKYLRGQESRPGEVKLLRKLDFFILSFCCLTYFFNYLDRSNLSNAYVSGMKEELHFHGNQLNVINTIFTVGYILGQIPSNLALTYMAPRIFFPTMIVFWGGLTMITAAVHNPQGIMAIRFFLGLAESSTFVGTHYILGSWYTEKELGKRSGIFTASGLAGTMFGGFIQTGIHSSLDGARGLSGWRWLFIIDGLITIPIALYGLFLFPDTPATTRAPYLTAAERALAVSRIPEASRARTPLDVTFIKKLFGTWYWYGFVMLWIIAGETESFSTNTLLALYMKAHPTQTYSIAQLNNYPTGVPAVGILSTLFWATLTDFMGGKRYLVGFFIGITGIVTSSLILARSSSTATVFGAYYWAGAVYACQATFFAWCNDVMRYQDDRLRSVVIASMNLGSNAVNAWWSIVFYSADLAPQFTRGMWAMIGCSIALMGWTGGIVWMTVREERGLSEEMVEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXJ4</accession>
    <name>A0A5N6TXJ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_139483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXJ4"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025012891" description="LPXTG-domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34261" checksum="19A064F2EB741B46" modified="2020-04-22" version="1">MASLHKLNASLAIYFLFILIQTIQVTSLGTINTSKCISVCGDDRKTTTSDLVCPDSSYNSSSNGETMKTCLLCQSTGTAYISDERNDIYTFLYNQKYTLQTCLFDKPADVSLSGCEGDCLPLKSVFEEPWYKTNYKRPIYEYCNNTGFNEYAGSCGKCLWGKSGSYVLGNYLDTMVSACETKPNASKGEIIKLNQPLFVVPNTTTTDTESSGLSSGAKIGIGVGVGVGGVILLAAAGWVFCLARKRRKARAKQAVYETEQVTYAPPDQAQMQFGMSEVPAEETKKVKEMPVSETGPAVELDGNMRKERPPVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY67</accession>
    <name>A0A5N6TY67_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sporulation-specific N-formyltyrosine oxidase Dit2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY67"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="57359" checksum="0AF74A7E4536BC7C" modified="2020-04-22" version="1">MVTLSIQLPLILLMSKAIILILPLLLLLNPTSKRSSIPAVPFWVSLYDTCRGVSRLQFYKTRLQPLLDRHGAVYVWNAGRWTVLVTKPEYLLRMFRNETVVAKGGFYRKVPWGSFAMLFGENIIDSHGATWDRFASVIRPAIQKPTDIESLRERSSQLADLFLTTQKNGSLTPGVTIDPLIQRWAIAVYGETFLDSEIGCMDDPANPLESSVTAVKSNIVGPLFAEFPFLEKLSFVFPRRRRAITAIKRFEHLLVKHVDSQAPTFNGKEKLIHRLLRARERSELTEFHYRSNLKMLTIAGHENAQLALTSALWEIGVQQSVQEELLKDISTLPKTYTVRELDRLPYLAAVICEVLRLYPPISQLINRVTLDDFDLANGLRIPAGTWMGWNSYGVHTNPEYWGKSAKEFQPLRWGNDINSVNNLFRLSQAKGHFIPFNAYSRRCPGSGFALVQLKVVLVEILRKASWTADPTYHFSLTSRSVLAPRNCRLVFTPRSEESYIHTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYD4</accession>
    <name>A0A5N6TYD4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_171630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYD4"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="338" mass="39368" checksum="05B64C6E5C3432C5" modified="2020-04-22" version="1">MGSLPSPGQTRSRLEALPAEIIQEIFLHCLEFNLPRASLHISRVLSNPLIYTWLIRLAFSSANESSRSAFFTSDFLPWPLEYFVLSVEQRRDLQNDILTCRWCTLPLMRKCQREYVEHVIHRKCRDLDFSPGDYQTLTTIGSRLSNTDGCDKGEGGSRGRGDLILKARDETTNTDYKVAIWFHFGALQIRRPKKLVTEYDLFRLPSCLPEAPACMPHKLLCPPWTEAKLDFLQLLSTDAYIDEDDSFPRSRRVLRQVIRSRDFATFQRLLSMYIRCQCYKYPVRWPVLPNHFSAALKYADEHDDPFIRLLVEQRWDDIPENQLQLKDALVSKLSSDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYF2</accession>
    <name>A0A5N6TYF2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYF2"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="427" mass="48499" checksum="BE50AD7AD5C720BB" modified="2020-04-22" version="1">MPQRYSPIVQELRDELLWEVDDLEQAVKNAQKWDIPELDKYGIISARGFLDFADWLIQGWVPTESTKGRDIYYILCVFYFVLSQEPLGSRQTKIAPLSINKPLKPLSDWVVRFAQEIGRSMDKPHSINEAAITTFRNSPLFRVFESENDYPNWKTFNKFFYRKLDQERDIDGPDDDRIVTFPADSTFAGAYAITDDSEVVLKNVPWKVSDLLGPYGSKEVPGEEGTTYGDLFKEGLWTHVFLNSFDYHRQHAPVSGTVEVIDVIQGAAYLEVLVKSDEQVGHNYLELCRRIAGNEKNPPSVVTLDAPDFPGYQFLQTRGVIIINNESLGRVAVLPIGMAMVSSVTVNENLKDQKIKKGEEISHFAFGGSDCVIMFEQKARVSGFPDSDPLAREHFFYGEKLCRAYFKTPKEKEGGKTFASRFGLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYJ1</accession>
    <name>A0A5N6TYJ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_171555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYJ1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="221" mass="25219" checksum="9D43D149D6DEB0DC" modified="2020-04-22" version="1">MASLKIIGAGYGRTGTLSLCRALDILGYSCHHMEKMLLDDSQDPALFQHAYQSKAGVDWDHIFRGYDAAVDWPAAAFWESLVHHYPDAKVILTVRDPEDWYRSVGNTIHNWPMNDGSAWPEKMMASRKMAKTIVKEGELKMYSNKEAMIEQYKTHIAYVCSTVPKDRLLVFESSQGWGPLCNFLGVEPPVGIAYPHLNKGGLFRERLMRVREKIEESMHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYX2</accession>
    <name>A0A5N6TYX2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_128697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A5N6TYX2"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="599" mass="68628" checksum="D29639FAAAE1FA7F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ57</accession>
    <name>A0A5N6TZ57_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_128569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ57"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS transporter, putative"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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            <end position="347"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="470"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="507" mass="56433" checksum="E2A53202A88DB05D" modified="2020-04-22" version="1">MIQVPSATERPHSPEVSTDKDDALAVVSEEAQEIDPVMERRVLRKIDWFFMPAMLIGYGFVYWDKAILGSASLFGMTTDLALLVVDNSTSPPTKDTSRLSWATSIFYFGMLAGLYPMTFILQRFKTQYVFGPIVMLWAITCAATAGVKSWQGLFVQRFFLGFVESVVPTGFMTIVSSYYTQKEQAMRQAWWFSGTGWFTIIGGALNYAFGQISSGALKRWQYIYIFAGALTFLFGLWCCIMPNSPVSAWFLTPQERIVAVERLRKGQTGVRCQKIKWDQIKEAFLDIKVYLVAIMMAAAYTINGAISGFGPLIVSTFGFDTLDSILFQFPVGGVCVIFIPLCGYISSRIPNTRIPMLIACCLPVIAGCVIIWKSEWGYQPAAPVVGYALTGFFGPVVSLIITLGASNVAGATKKTIMAATVFVAYTVGNIIGPQLVNSKTVDRHYPELWTGMVICYCITIAAAAALYLVLWRENRARDQMDLGESQRDKLAFQDLTDKQNPFFRYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZC8</accession>
    <name>A0A5N6TZC8_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_128587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742066">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
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        <location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="186"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="522" mass="56601" checksum="5F5C03B423A11D07" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZC9</accession>
    <name>A0A5N6TZC9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_171471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZC9"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="180"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="34462" checksum="3204A72733068DAA" modified="2020-04-22" version="1">MTSLLSYLWGTPKASATEPRSYTPPTFPTPGIYVIRSLAAELVIDLSSAARDDGTKVVAWGYKDVDHQKWEIADAGHGQFLFLNVATGTYLTADERAIGGLTYTSGSLVSPTNNRARWTIESGSEKDAYIIRNVASPAEVLSLADGSGAYNTPVTIHKEKDTKIQQWYLERLDAPPRPEVVKNTPVGGKGGSSFEEYKFSPVRVVEVWTGVLDDEHVIRGLQWTYDDGSKSALYGANKADHHEVVVIGPGEKVKSAAVSSGKRVDSISIEKVNGDKFKAGGDGGKEHKQDVGNGTLVGFNGGSGLDVDRIGFIFLKKGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZE4</accession>
    <name>A0A5N6TZE4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_93263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZE4"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="620" mass="69757" checksum="14CF42711BAC9B6C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZI3</accession>
    <name>A0A5N6TZI3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZI3"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="307" mass="35451" checksum="D7BDF591BA91FC6C" modified="2020-04-22" version="1">MTQTVLDYLTKPEPELNYYQNLDWQTPTYNSDWNPIENIEEWTDFNYENIVKRYYADLHQPVNPDDLFNPTKMWERIGMNNVYSERGLEHKILLKNILVVSSVLPEHLFIGNGANTAEEFDIFPDWGTGDKRRLNRQDRFKAILGGDTKYNWSHCEAISIIQSSPNGYEYHPRKHIVRPFEQNQHYARKLGICYQFSGKEDAFLFQRFWLSPEPVRTSPRPQRKTRFQGHHQRVISSSTVSDVGSSIGAMSVGEPDLLPDIAGLHCAEVPSTGRPDGLTPNLALYALIRMAAEDSQLRSEYPPMDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U054</accession>
    <name>A0A5N6U054_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_83918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U054"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="689" mass="77521" checksum="746BC9071E68F112" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1M7</accession>
    <name>A0A5N6U1M7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_137769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1M7"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="377"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="660" mass="73949" checksum="BCA1821D36E8D2E8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U233</accession>
    <name>A0A5N6U233_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">BDV25DRAFT_170384</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U233"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="16"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAE8152469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="266" mass="29466" checksum="A490FED9EEA6B4ED" modified="2020-04-22" version="1">MTYTPPPLPPPYTNTSPPPTLLTQGAEAHLYKTSYLTPTTPAALKIRPSKPYRHPILDKRLTRQRILQEARCLVKLVREGVSVPAVLALDYEGQSENNNGGAWLLMEWIEGLVVRVVFERWEAFMKCSGELGGKELEREEKKVRGLMRGIGGVVGGLHRAGVIHGDLTTSNLMLRGLSSGEGEGSPGMEGDVVLIDFGLASQSISEEDRAVDLYVLERAFGSTHPRAEKFFEHVLEGYQGSYKGAHITLKRLQDVRMRGRKRSMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2B5</accession>
    <name>A0A5N6U2B5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2B5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="342" mass="38931" checksum="7DE22F8C546CEBA6" modified="2020-04-22" version="1">MSEGIVIDEFPHYRIVDFYINDAAANLTIMCGGNLFKVDVQAIDLKDTEFETGYQYWLEMLTTLSLCIYPKPNTVERQAMVLEFSKWLLRPCLSFVEQEAQDMKNKSISLEDYAFPTAWSLKLMAFNDCMFFLRPEKIFDCALRTVSVPLTGIRTAVRRIRATTVFSEGLDGDRDPGCDIPRHVKFGQFDLFFKPVKTPQGFKREVTLLHDIQTFNLPVRVPKLHSIVLSEAGDKALGILLQWLPFGSNTLLSQKGEEAKRLHDKWESQVGEILEHLHQKSIIWGDVSPSNIVIDWNDDAWILDFAGGVDEDFVDKQLAGTPGGDLGGIEKVFRSWLPDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U341</accession>
    <name>A0A5N6U341_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthesis regulation, congo red resistance, RCR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U341"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="143" mass="16295" checksum="052861ACAA9FDE3F" modified="2020-04-22" version="1">MVTYCRDRWGNRYRCRSTWHHWGRWLFLGLIIVAAIVIFFIFACTSARKRRRRGQQPFYGTGWTAAGNHPPNQWQQQPQPYPNQAPPAPPGYQPDPGYGPNYGQHQGYYGQPPYGSDVQHPPNAYARDGVYSPPPGPPPGTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3S8</accession>
    <name>A0A5N6U3S8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_127410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3S8"/>
    <dbReference type="OrthoDB" id="5083627at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="482" mass="54361" checksum="AA8804AA35CECD87" modified="2020-04-22" version="1">MTVTKSDLHTAMKDQTTTSDWDVLVSYRTDALNDFLSNAWKDRIETKEIEFTVTQTRGRITYYTDFVVDIGGPILQFSNNQGAWATLSLDVSGTQTFREDPDNPIVIPAGYYQLMCTLPLTSVDGEGEDQRPADGSNIYLFDKDDASYYVTFDFHNEDANWAVKEVKHLNDSTLDLITEALDDIANHFKEIDSKFLLSICLAEVANSQHADVSGLLTPESFSLACQDDVLCVFIHTKEGREGKKDPRFNLRSGYDYSPIPDGYNASVIISRDIVIDKYLLPEIRNNKDALLRADDGVMEKGGVGDVGEKTGALLEFRYADDLITNPEWDNYGNLQLDFGGMSIDLDKQPLILEIQDDSNLQPKYTWKWECKGTIHYTEWSNGYPIDFDPDYNVSIAPNSSDLTSLHDDKISWNISFTDSNQPDGTKGDQNIGVNVTLYKFDLNLPDLDYFRTTNIFAPGRHMIDATDINFPYDLMILGNIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U492</accession>
    <name>A0A5N6U492_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ketoacyl synthase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U492"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="147" mass="15998" checksum="A3CE764B208ACF79" modified="2020-04-22" version="1">MASSFCREVMRDTRSGTGILAVIGLAIRLQGKITSPEGLWDLLVRQENMSVEIPKTATILITFTGSRTAKARRGSFLEQTLAEVHPSAFDNGNMVNHLDPQQISLPEITFECLENADRHLGEQLTYGAMLAASARTGNSLVSGILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4E2</accession>
    <name>A0A5N6U4E2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 15">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="6 14 15">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_149270</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 14 15">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14 15">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6 14 15"/>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4E2"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14 15" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024915941" description="Endo-1,4-beta-xylanase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="17">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8153505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="227" mass="24249" checksum="A3A8A3D4A513B718" modified="2020-04-22" version="1">MVSFSSLLLACSTAIGALATPIQERTDFNETDGHNLIARSTPSGTGYHNGYYYSFWTDGGGDVTYTNGNGGSYSVQWSNVGNFVGGKGWNPGSTRAITYSGTFSPSGNGYLAVYGWTTDPLIEYYIVESYGTYNPGSGGTYRGQVTSDGGTYDIYTSVRTDAPSIIGTATFTQFWSVRTSKRVGGTVTTGNHFNAWAQFGMSLGTHNYQVVATEGYQSSGSSQITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4I4</accession>
    <name>A0A5N6U4I4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_149806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4I4"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="572"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="779"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="842" mass="90342" checksum="4A9428F895838583" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4W3</accession>
    <name>A0A5N6U4W3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_168615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4W3"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="7">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="398" mass="44282" checksum="BEBB8CDDCCCACB0E" modified="2020-04-22" version="1" fragment="single">MDHAKIKSLLADAQSSLQAYEADEVEATRKEALERVLKLARAIEKPRDAILKLGFSPTILMAVKVAVDLDVFNSLCNASASVPVDELAAPKSADPLLVERIMRLLVAHGYADESAPCEYFATALSKEMTQRTSIGVVESIFLDLLPAAQKTPEFLQKTGYQNPEEPTNGPLQYTNNINVDTFTWLCQNPESMTRFNAFMQGQRADRVFWADWFPVQERILDGADKSADGPLLVDIGGGLGHDLLGFKERFPDAPGRLILEDLPEVVEDGKATLGLEAAGIDAVSHDFFAEEQPVKGARVYYFKNIMHDWSDEKLRLVFKLLATAMKPGYSKIILEEYILPDMGARSLESMTDLGILVFCTGMERTRQRWINLMDSVGLKAKFWTREGDAQGIIEAEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5D2</accession>
    <name>A0A5N6U5D2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cortical protein KAR9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_127232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
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                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Chovatia M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
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</entry>
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            <strain evidence="9 10">IBT 18842</strain>
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</entry>
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        <name evidence="2" type="ORF">BDV25DRAFT_5188</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="125" mass="14041" checksum="D1874452401C39FD" modified="2020-04-22" version="1">MVATFIDINPRTPLSEQLKEKPEAGPCVLVNTFHIPAGKMEEAFAAWKIDAELAKRQPGFISTQLHRGINGSDMMLNYAIWETTAALKAYYDLPEFKESLLNYPDGTEARIALYRKQHIDGICLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U617</accession>
    <name>A0A5N6U617_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U617"/>
    <dbReference type="OrthoDB" id="4224309at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="188" mass="21024" checksum="A0A8F22E92441AE5" modified="2020-04-22" version="1">MAQNWPHNHSFQVVKMASSSRFIVPPPSKVRLTEKNVALHNAIEGLAEPKTIMSWMEKVIVDESTQAFYSELGLQYLDDKNDGEPLDFEESMDQLTEVASGAAINGLEYITKSLKLFSRKSEKACRATPLERFLTPDGNSDPVIFSRSALAFMGAGYGDLEGLEKRTQQMKENVGKVARNKLRKPKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U6H9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_148134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6H9"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="128"/>
        </location>
    </feature>
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        <location>
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            <end position="233"/>
        </location>
    </feature>
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        </location>
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            <end position="373"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="394" mass="44185" checksum="64531F4BB2274D11" modified="2020-04-22" version="1">MAFAPMSEMFGRRPVYALTLLLAVIFIIPCAVSKNIGTLIVCRAIDGIAFSAPMTLVGGTLADLWKNEERGVPMAAFSASPFLGPAIGPLAGGYLADAAGWRWLYWLMLILAFVAWVLITFTVPETYAPTILKRRAKKLRKTENDSTYVTETELDSRPMGEKLRIFFFRPFQLLFLEPIVYHLRVPLQWSNTVLVSYPIIYQGGKKWSAGSTGLMFIPLAIGVVMSAVCSPFINKHYLSLYAKYGGKPPAEARLIPMMFSCWFIPIGLFIFAWTSYPDLHWFGPAVGGWPVGFGFIFLYNSANNYLVDTYQHQAASALAAKTFLRSIWGASTVLFTEQMYDRLGDQWASTLLAFIALACCAIPYVFYFKGESIRRLSRYAFTEDEENVGKTEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6R4</accession>
    <name>A0A5N6U6R4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_172355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6R4"/>
    <dbReference type="OrthoDB" id="4479825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="502" mass="55201" checksum="1C28282356376B5D" modified="2020-04-22" version="1">MDPAECRQAYTKTFQDQTSGTGLPAFVACRCGGELWGRNDRPELHLATVMGHTLMHYGGENHCGPCIKTGTIMLFRAWLLSSSEDRELIALTYTAVNECVSRRHILTANQNEIAHEASMDCPRPCRQRALAWCQGMGIPGMAFDLLDGVAGDLTGSLRDDMTALCDSPGVNMPPEYASLHPYLRGLATLYCYIADVGPGCTTGHAVPITHRPVRKVMYPSLDAYVRERLADGYWMALDAGVDSPTADDFYFNIDSVTLKEYAIDTVCAFDTFTHERALKEDALYGACDYERNREHEPQTSPPSAYQDIIYSAGYVGLSSFVWGAKVHLDVLRGQATHSPSPPPDHWYARVWHDALLGQSTPGVLYQCTIAGKTSGISIGDRKFTGCEPECSCPKRYHDYGLGATISWTREAWCGLPCSSKPFDVWMFGAFVDAMRSTRRCGEGRPSPVTDLKASAARPMQKACIGDLAQVRCQIVHLLVWCAIDKQSAAPRPGIGTLCQDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6W6</accession>
    <name>A0A5N6U6W6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_109073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6W6"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF4">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="36419" checksum="8DC0F5B856095CE2" modified="2020-04-22" version="1">MQAIRLHPSANTTSYSPENPAPSSALHLDHDIPIPKPSQPGDILIRIKATTVVRDMLTWPETYHHEYMIPGHDFAGTVVEVFPGETQFKPGDEVFGMAHADRGSMWAEYGLVKDCEVALKPENLSWEQAAALPLSALTAYEALVEKAGVLINRVAGKAPSESKAKTILITGAAGGVGIYIVQLAAIAGLYTVASSSSNLRNRDLLLELGADETVEYGELMSQNRTWDIVIDTVGGNVLADCWSYVKDDGSLVSVDSASFDFVKKHEEKGIRKKNVNALFFIVEPNAKALNDLAHYARLGLLRPFVLDTHPLARASEAYESAGRRVVGRGKLVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Z0</accession>
    <name>A0A5N6U6Z0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Z0"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00257">
        <property type="entry name" value="beta-trefoil_FSCN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="164" mass="17999" checksum="847DD353C8F247A4" modified="2020-04-22" version="1">MSSSTKNMLRVSIESQKFPGSFLRMDGKDVKEYTGSGSGVVNVQNHVASYETFIIVNHPEEKNISIMSAQFPNVFLRLDGTHVQSGEEYASGAGTVNCQWGSHSYEKFRLEDQEDGSKAIASVKFPNVYLRLENVSGQGGPSGAGTVNCQTYVGSYEKFKIRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U765</accession>
    <name>A0A5N6U765_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U765"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="257" mass="29310" checksum="9E394E6CB65B9601" modified="2020-04-22" version="1">MSFLWPTSPAESQPTEEPRVLHSLALRSVTVHGEQVIKSGPDLYGHEASNLKYIAANTTIPVPRVHKVEQGGDGKTKKIYMDYMPGKPLNKAWPEMTEDQKQSVASDLRNYVEQLRNLKGTYIGAANRGQAVIGKFVAHGGGPFDNESQFNQFLFSRILPKVPDTFRYHATKTFKTNHEIVFTHSDLAPRNILVDGGQVTAILDWEFAGWYPEYWEYVKAYSDFNAVPKWLDNVDMFLPRRYTEEIIAMAYLNHFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7C2</accession>
    <name>A0A5N6U7C2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_147783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7C2"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8154502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="52146" checksum="C6D5432C1DA8460F" modified="2020-04-22" version="1">MQSMPLLLRQSLRSTVTLPRSPRPLRSPLLPVGPKPLPAGRRPFSVCVQCQFRSQFALYSSNETDKLRDVKAAEQSLDGGGSVTGSPGGSSTGELGSQEAPLPREGSMNAQSQPRGEEEKAETSFRGVGSSLPSYFEDHRSQLSKQFTTMMDNLQSNVFVAGQRLNDLTGYSSIEALKKEIITQEERLRAARRRVRETKDAYAAAINNRSTSQREVNELLQRKHAWSPADLERFTHLYRNDHTNEVTENESQEALTLAERESEEAAAQLNKAILSRYHEEQVWSDKIRRMSTWGTWGLMGVNVLLFLIFQIAVEPWRRKRLVKGFEEKVIEAIEKEKTLNRVELLTPTQEQQTTEITTPDTVTATSTAVEEQEPTAATETIEQATPDTKNTNNNLTALNDLLESAKSQLSRFPPPASIESWRQYANELFSDRNIVITQRDLSSLALQSAAAGAAIMGLLFALIRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Q6</accession>
    <name>A0A5N6U7Q6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7Q6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024886034" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="89" mass="9813" checksum="061D6D392CE23235" modified="2020-04-22" version="1">MKTAMIAAILLAFVPAVLGFIGQGECGIVNGDYYGYCEFRGEDFKPLFKEGENFYRHPCVAGRCTRKGNSCAAEYFLGKGVRVLNPFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U892</accession>
    <name>A0A5N6U892_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U892"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81853">
        <property type="entry name" value="Family 10 polysaccharide lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18559" checksum="3C7D108CF676A480" modified="2020-04-22" version="1">MSTTDPTRWRLIVDEGDHQRQYLSEVDSARRPPTTAEKHFLGLPTVKLPSLQIPHNFQQSVRNGFRFYQNLQLNNGHWGCGYGGPGLLLAGIVIAIYITETEISPEWKAEIIRFLSNTVNEDGGWGSHSAGASTVFATTLLCYIANPRAPTEPFAHQQGACPLTRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8L9</accession>
    <name>A0A5N6U8L9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_63898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8L9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="212" mass="23777" checksum="C638A13A057AEB4C" modified="2020-04-22" version="1">MDFPTVIAVTMTATVMVIVTGTVTGTATGTATATASVTAIGTEAARTTEERDTMRMMHTMTHAPREDTEFPPHKRISSHSVLSTVYWWVFLMNFPVTSHRPLRQWVRQGQQLFKSHASRLGHYLQQSRRYASSSYTGNDVLDPPGCHQYLIHGTAVYFLRRVDVHGTSGRNPLMFSFPYSVLCFLACLFTLLLFSSSFSRVCTALLRGKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8V1</accession>
    <name>A0A5N6U8V1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_146874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8V1"/>
    <dbReference type="OrthoDB" id="4206905at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="34888" checksum="611EC2E0A866C86F" modified="2020-04-22" version="1">MDTLILNRLGKTEPVRLHLDHIFRTIKQSETTTLDEHDLSRFKIKVSRLDLDTEGSFFKPLPRSQLPQINWDEVNFSDWAAGETNEARRVDYTFLRVSSHIWNATFQNSDQEWIPRKYYHEDTNIGGSVELRPLEWQTTGEVEEKWRRKPHCSYRIFHYAEPSDALRRGEVLSLLRYMRWRMQQGSFLQHYTFPVLICSISRSKVRLLEAYHDGESLCISKSEFYDFKENVVENYQLFMQWIFGVPCGDTCAPLQITGVEFAPATKKRILSNLARKARLADARRKHLERHMIVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9B0</accession>
    <name>A0A5N6U9B0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9B0"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF94">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45442" checksum="5D3100130DA4FE39" modified="2020-04-22" version="1">MGRVADIHLDGAPGEPLNVSPSIINPILPSEPNGDELQDQKMSLLDDGSSDPPSTQFSFFTSQLDTIIHASSVESLRSFYKPFDALLDTRESPGLWWLDVTAPSDSDIETLAEIFDIHPLTTEDIKIRESREKIELFGRYYFVSLRPPHQIGSTEGNRSATLNVYAIVFREGVLSFSFGNSPHGSHVRNRVKEHRSHLALTSDWLCYALIDDIVDGFAPFINRCQTGVEMIEDDVSITRPDDIGLALQRIYQYRKQVAQIRQLLNDKTDVIRCFARHCDSFGPASTNVALYLSDIRDHVLTMMSNLYNAEQMLSRAQEKYLSQLSFDSTRMRNEIAETLSRLTVIAGIIVPMQFITGLFGMNVNVPGQPPEDEIGPLSWWFGIFGIILGLILTGLAVAKRFRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9P8</accession>
    <name>A0A5N6U9P8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_167725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9P8"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DUF7580" evidence="9">
        <location>
            <begin position="164"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="634"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8155310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="884" mass="99241" checksum="29E136F0C392F29E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UAS2</accession>
    <name>A0A5N6UAS2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_167726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UAS2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="752" mass="84234" checksum="E68BCE1D73FC8340" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCU1</accession>
    <name>A0A5N6TCU1_ASPAV</name>
    <protein>
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            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ML742660">
        <property type="protein sequence ID" value="KAE8144208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCU1"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF11">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Six-hairpin glycosidases"/>
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    </dbReference>
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        <location>
            <begin position="170"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="356"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="468"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="817"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="920" mass="104726" checksum="2BCC00D25002038F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCU6</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_121164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742921">
        <property type="protein sequence ID" value="KAE8144107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCU6"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
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    </dbReference>
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    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
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    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="583" mass="64892" checksum="8FCDE5EF7579E457" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDA4</accession>
    <name>A0A5N6TDA4_ASPAV</name>
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        </submittedName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAE8144257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="524" mass="58915" checksum="1CEF8654401F3250" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <accession>A0A5N6TEK1</accession>
    <name>A0A5N6TEK1_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_166050</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="85" mass="10313" checksum="BE11500E634A6D6A" modified="2020-04-22" version="1" fragment="single">MVPPSLSFSFFYFLFFIFFNHIPLLQMSVSHRDVTTFCPLTLYWFVPWNPFPDPEDHCSLDLPFAFTENPFREGHTKMFEWLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEN5</accession>
    <name>A0A5N6TEN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_166497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742482">
        <property type="protein sequence ID" value="KAE8144579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEN5"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="303" mass="33700" checksum="127A1E4696B9EEE6" modified="2020-04-22" version="1">MFGIIADLLSSVVTILFPIFASFKALRSSDPSQLAPWLMYWVVLSAILMAESWTYWILGWLPFYSWIRLFFFSYLVLPQTQGAQILYRTHVDPFLAQHEQEIEEFIGRSHERAKALGLQYFYQALDWVRENVFHLPAQAAAPPSPSNGPASYAQSLLSRFNIPTAGAPAGASAPAQNTDWLSAIGSAVSSMTSTGKTPEARAEELSSSNSFLPRELAGMSRDEKAKYLSNQQEMLEVLRNALAKEQNTLDGNGLRKNRSDNSFDHIDPEDIRDRTQAGGNNWASGAEFAARAAEEITRSRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TES1</accession>
    <name>A0A5N6TES1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_84329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742422">
        <property type="protein sequence ID" value="KAE8144873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TES1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024919981" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="87" mass="9640" checksum="1FC1CA16BF11A83A" modified="2020-04-22" version="1">MILLLLLSFCILGPVTPRDAAYRLLSCDTRLSPIASISILPFLSSSPFDPESSSNFLLLPRLFGIMAFPLNTYIKAIVVHGFTRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TES5</accession>
    <name>A0A5N6TES5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_145267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742434">
        <property type="protein sequence ID" value="KAE8144796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TES5"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="46277" checksum="F7EC174887AD2834" modified="2020-04-22" version="1">MPQSTPNRGQDTHDYTLRFSKDGTFQITMFTDLHFAEDEDTADGPAKDARSIEVMENVLGYDTQQLVVLNGDQISGYGTKADNTTAYVDQIVGPMVERDLPWASTYGNHDHQSFADTLKTFQQETTYSQCLTQRMIPGEPDDLGVSNYFLPVYPAVGSQVDSEATPELILWFFDSRGGNYQNDGRERPDWVHSEVVEWFKEKNINLTTQYGKTIPSIAFFHIPLSAAKFFREDPGVNPSREPGQNGEVVSNQGEMYDHKTGHDIELMWALAKADGLLATFSGHDHTNDWCFKWTEDLPGQDVPGSGVNVCYGRHSGYGGYGDLDRGARHIVLNKDTLQKELVTWIRLEDGRIGENVTLNATYGKDEYHPGPVHLELKRDQFENTGLALAPSILSTVLCLFMIFYLPLRLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF13</accession>
    <name>A0A5N6TF13_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_165866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742419">
        <property type="protein sequence ID" value="KAE8144886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF13"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000081">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30376" checksum="E0F960A0B9664281" modified="2020-04-22" version="1">MTALFTIPVSSTGGTIVCSNPSALENEKNIYLLTFTSPKDNRLTPTFIEAFLLALDIIEHRYPKGVVITTSGIAKFYSNGLDLELALSTEGFLDKWLWKLFRRFLTYPMPTICLLNGHAFAGGLMLAMHHDYRIQNPSKGFLCINELEFGVTLQSPMMSIFREKLTPISFRSLILEAKRFSGPESVKAGLVDGLGGVEEALVLIRERGLQTKAATGIYGAMKEEMYRHSLGILDSHAANLAWREEVEAKKDRAHMDSLRAIEAFEKQRSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF30</accession>
    <name>A0A5N6TF30_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_165932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742425">
        <property type="protein sequence ID" value="KAE8144850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF30"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="216"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="153"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="382" mass="41587" checksum="57AEBF134445C1E7" modified="2020-04-22" version="1">MYPPLGSIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADGLSLLFLVVWLAGDVFNILGAVLQGVLPTMIILAIYYTFADIVLLAQCFYYRGFTLRDEPSPPVSHAPGSDVEDQSPVPRKVSERTALLSTKANDQSYQAHTPEQISNGHTTSSSSTQQPSHHQKHRRQSATSFRDILHPNVDGTHLSPVTPFVEPPAKETRDARKLSTAQSVLLNISAVTLVCAAGILGWYVSPGSKSKGDDNGTKSPEFDTLGQVFGYLCAVLYLGSRLPQILLNYKRKSTEGVSLLFFLFACIGNLTYVLSILAYSPVCQGYAAHGRVGHCQPGEAAALYSRYILVNLSWLIGSLGTLFLDLVIFVQFFLYQDKSEEVASGETVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF33</accession>
    <name>A0A5N6TF33_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742405">
        <property type="protein sequence ID" value="KAE8144984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF33"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="48"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
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            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="156" mass="17940" checksum="8321A00E17AB88B4" modified="2020-04-22" version="1">MATAEKKKEEQPAVQPDEYSDGDYDTDDYPLSEDEQDYKPQRPAQQQNRRRQQRKRQDKYDDESAFLSDEYDSDEYDDDEFDDDQAARDNAMQPYQRGTQSLTNNTISNGAMTDAPGQGKNEDEQDGLKLKLELNLDIEVELKAHIHGDLTLSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFW9</accession>
    <name>A0A5N6TFW9_ASPAV</name>
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        <submittedName>
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        <name evidence="6" type="ORF">BDV25DRAFT_144808</name>
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    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8145268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="62"/>
        </location>
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        </location>
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        </location>
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        <location>
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            <end position="486"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="519" mass="55791" checksum="4F3F0637506C0D02" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGD0</accession>
    <name>A0A5N6TGD0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BDV25DRAFT_170550</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
            <orientation evidence="16">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742346">
        <property type="protein sequence ID" value="KAE8145434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGD0"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024879313" evidence="19">
        <location>
            <begin position="21"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="22">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="154"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="362"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAE8145434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="592" mass="65713" checksum="26AE0B67EFD14E4E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THN2</accession>
    <name>A0A5N6THN2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="13">dUTPase</shortName>
            <ecNumber evidence="5 13">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_61134</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5 13"/>
    <dbReference type="EMBL" id="ML742309">
        <property type="protein sequence ID" value="KAE8145827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THN2"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000007">
        <property type="entry name" value="dUTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="15">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8145827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="191" mass="20218" checksum="80C3498D8290AF4F" modified="2020-04-22" version="1">MTKEATPPTEQQSNNPTHEPPSLPASPVAKRTKAESTTMTNPAVTSISQPLPPLFIKKLSEGGRAPTRGSAFAAGYDMYAAKETVIPSKGKALVDTGIAIAVPEATYGRIAPRSGLAAKHFIDTGAGVIDADYRGEVKVLLFNHSDVDFPIKEGDRVAQLIIERIYTPEVQVVEELEESVRGAGGFGSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THW8</accession>
    <name>A0A5N6THW8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial PGP phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_163974</name>
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    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="244" mass="27443" checksum="2605D2406CE756CE" modified="2020-04-22" version="1">MPTPPNTNLRAFNLAVQTLLKNPSQFLPHLTIPTFTHLPEQVGPSIAENLNLTAEAKAPTIRALVLDKDNTLCHPKTTTFPPQILEKLQALRTSRTSPFNGEQYPDSILIVSNRAGSHPRYDAEVRDLEEQLSALRIPVFRLPEGSEKKPFCGDEVLEWFRERGVVKRADEIAVVGDRLGTDVLMAARMGSWSVWCRDGVTEGVNPKDGRPDMNLLEKMEVWVERYLRESKGLKAPPPQGWSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY6</accession>
    <name>A0A5N6THY6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_133350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="111"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="323"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="5">
        <location>
            <begin position="1309"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1257"/>
        </location>
    </feature>
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            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1476" mass="160903" checksum="6C81FF27BC38EA6E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIK1</accession>
    <name>A0A5N6TIK1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-dependent phosphatase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_143941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742281">
        <property type="protein sequence ID" value="KAE8146176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIK1"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62253" checksum="E08BA0058B5AB197" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ20</accession>
    <name>A0A5N6TJ20_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742270">
        <property type="protein sequence ID" value="KAE8146332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ20"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="164" mass="18457" checksum="565290BD489D9CC2" modified="2020-04-22" version="1">MTCFFKPADIPEHTNRETSTLLRIQKLGLSNILRAPKIHGFVEFQRASSRISGILLEYIEHCNTLGHINIPTTPLPVRVKWINQLRNTIKMLHSAGIIWGDAKPDNILVDADENLWIIDFGGGYTHGWVDEDKESTIDGDNQALFKIVDFLLDEAQNSVPHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJF2</accession>
    <name>A0A5N6TJF2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_162336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742259">
        <property type="protein sequence ID" value="KAE8146476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJF2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="76" mass="8480" checksum="6F7A3DD0E53945FD" modified="2020-04-22" version="1">MFCISPCSLSLKYPVYLRCFISPLALFFLSRLSATAQCDPLLRGRTLPKVRLSPTTRLVSASVTGEFPNTGNRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKE5</accession>
    <name>A0A5N6TKE5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_161649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742240">
        <property type="protein sequence ID" value="KAE8146822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKE5"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001281">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001719">
        <property type="entry name" value="C2H2 type zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1047" mass="118560" checksum="F41675FD78B6606F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKZ9</accession>
    <name>A0A5N6TKZ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="18">AAA+-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_161483</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742234">
        <property type="protein sequence ID" value="KAE8146950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKZ9"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="317"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="720"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8146950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="754" mass="82291" checksum="428AB105521AA62B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLE2</accession>
    <name>A0A5N6TLE2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase H</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_39102</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="ML742222">
        <property type="protein sequence ID" value="KAE8147158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLE2"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF17">
        <property type="entry name" value="BETA-GLUCOSIDASE H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="18">
        <location>
            <begin position="387"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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                <person name="Daum C."/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21379" checksum="B05C139082CB6B4A" modified="2020-04-22" version="1">MLDCATPVQGPGNYRALKIALKTVKTCTENRLLELSQKIIEIVAIRLDAFKKSQDECNILNVTSVTIEYYTIRVYLAWLQGRLDIAEHLFSQIPDTIPIQKQKGLCELCYRIGSSTLGDHQYNTSAKWLQRALDTYHHDGTNDDKEALQYAKVLVLHASVRANLHLEGSDCQDRLTRSLQALRKVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMP1</accession>
    <name>A0A5N6TMP1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742210">
        <property type="protein sequence ID" value="KAE8147379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMP1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="59" mass="6451" checksum="2738720A4BD9C115" modified="2020-04-22" version="1" fragment="single">MHLHHQLAPNSTVQVSSACSEGFYNTRNNKFGAGGPKKSRLDCVKRASDKEIPCKVTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMQ0</accession>
    <name>A0A5N6TMQ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_33861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742210">
        <property type="protein sequence ID" value="KAE8147381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="343"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="902"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1331"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1381"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1408"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1453"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1617" mass="178281" checksum="E6B603670DE096CD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN03</accession>
    <name>A0A5N6TN03_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN03"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9367" checksum="48FE43E6979E8683" modified="2020-04-22" version="1">MFPTRVLRMQASRPFAFPAPKEAHSAHTISQRLRSLRRVPPELIPLGIVLGVAVGAAIYSSSKKLMTDKTLRLYRNSPEDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNZ7</accession>
    <name>A0A5N6TNZ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_131560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNZ7"/>
    <dbReference type="OrthoDB" id="1448at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:tRNA queuosine(34) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="358" mass="39971" checksum="D76A3DC74E6DD355" modified="2020-04-22" version="1">MKTDDFDFKQDPASMPHDPVQLRGRTRDSGKMVVLNRSTQSIEHTIFSKIAEYFRPGDLLVLNDSYMLSNTLPFKSAADDGSTTAHITVYGHEPDGSTIVEIKADKHQQPGTVLRSMHDPRLTCTLAESQPDNLWRARFDPADIFMEVLDRHGHRQDETIPLDPIHWKTNPAAYRSVYARKPGSLEIPSAGLHFSNELLAQIAAKGVDTAFITLHVGATEILAVRHISEPEIENHKVRSEYFEVGEETAAKINAALAEGRRIIAVGTTVMRTLESLSSGGEAEAPVRAKAGWTDLYIYPGFRFRVVDVLLTNLHRPRSSHIVLTAAVAGKELVMRSYEEIVRMGRHEFDMFGDSMLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPB8</accession>
    <name>A0A5N6TPB8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_23890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742181">
        <property type="protein sequence ID" value="KAE8147989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPB8"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="594" mass="65030" checksum="9B116E4529107034" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPE0</accession>
    <name>A0A5N6TPE0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BDV25DRAFT_21163</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="ML742170">
        <property type="protein sequence ID" value="KAE8148216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPE0"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000162">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="25" id="KW-0430">Lectin</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024935388" description="Crh-like protein" evidence="23">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="251"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAE8148216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="409" mass="41877" checksum="35ED389391039F4F" modified="2020-04-22" version="1">MYFNYAAVALTALLPLCSAQTYSKCNPLEKTCKPNPGMGSQFSSDFTTGDGALGGWITTAGKVTTGGQGAEFTLAKRGDAPTIDTDGYFLFGKVEVVMKAAPGTGVVSSIVLESDALDEIDWEALGGDTTQIQTNYFGKGDTSSYDRATFVNMASPQADYHTYTIDWNKDQTTWSVDGNVVRTLNFNDAKGGSRYPQTPMRLRLGIWAGGDPDNAPGTIEWAGGKTDYTQAPFTMYIKSVNVVNYTPAESYTYSDNSGSYQSIKTSGSTESKTTSEIRSTTSTTSTATSSSSTETTPETSTESTTSSKTTATGFTTTTTSPVGTTTSSASDAASGSATGGSGASTGVSNTGTPTTGSSTGGAGSGSGTSSSSAAGSSQTVPLSTNAASAPGAFMGPLTIMGLMAAMVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPF1</accession>
    <name>A0A5N6TPF1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_22355</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="ML742172">
        <property type="protein sequence ID" value="KAE8148170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPF1"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="101"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="16">
        <location>
            <begin position="341"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8148170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="60800" checksum="B1291EEB2AA9E883" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPJ9</accession>
    <name>A0A5N6TPJ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742167">
        <property type="protein sequence ID" value="KAE8148283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPJ9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="65" mass="7803" checksum="F68AB44F831977C6" modified="2020-04-22" version="1">MMTVTKTLQYFQAYNLLLIDAAVKTLFCLLVYYRPKINRSTNVPQRISRSFFWLDKYVETFGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPP2</accession>
    <name>A0A5N6TPP2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742168">
        <property type="protein sequence ID" value="KAE8148250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPP2"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="545" mass="58860" checksum="9E52AABFED5DCE9E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ89</accession>
    <name>A0A5N6TQ89_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_131163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ89"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="156"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="430" mass="48405" checksum="A0BED0A9A770EF4E" modified="2020-04-22" version="1">MPFMLDEQPTLNVAIVGGGIAGAVLAIGLINRGINVKLYERARDFSEVGAGLGFTPNAEWAMKVIDPLIHVAFKKVAVQNSTDWFTWIDSYTANEATDGSNDELIYNMYLGERGFEGCHRAQFLDELAKLIPRQCVEFRKNLRTIEERGEDQKMVVVGCDGIRSRVRQLVLGEDHPAAYPGYSHKYAFRGLIPMEKAVEVLGEKRTASRFMHLGQGAHALTFPVAGGTLLNVVAFVNDPEEWPHSEKLTSTGTKQEAVNAFKHFAPTTRAIIDLLPEKLDRWAIFDTFDNPAPTYVKGRMVLMGDAAHASSPHHGAGAGMCIEDAAALVGLLQMVQSEMQHSKHTMSDLLRLALATYDQVRLDRSHWLVETSRYVGELYEWQHGSDPVKISREIDWRARKIWAYNIEEMSRLTKENFTRRLWKLDEALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQG9</accession>
    <name>A0A5N6TQG9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_15585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742153">
        <property type="protein sequence ID" value="KAE8148603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQG9"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="8"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="480" mass="52009" checksum="B1F331C6A7BE7900" modified="2020-04-22" version="1">MELFKKILTELGLLSLWQSSRDVELLCAQRFVRLFAYGGSTLILASYLSALGISDARIGLFMTLTLVGDVVISFFLTLFADTMGRKAVLLLGSILMAGSGVIFALFGNFWVLLAAAVLGVISPSGNEIGPFRAVEESTLAHLTPHELLSDIFAWYSLIGTAGTALGMMACGWAINLLQVIRGWQFLGACQAIFFAYAAIGVVKFILSLALSSNVEAEEKQDPTQQQGDNTETRPLLDSLAQPKTKPLFSLLKDENLVSLVTRLSILFALDSFASGLASLYVGIRSKWIYILITMPIAYEYCVDYCRSWMTYFFKRKFALPEAKLGSIFFTTSIIAAASMLVASSIAKRFGNIKTMVFTHLPSAICLALIPVPNILPLALTFLILRACSQNMDVAPRSAFLAAALPSDKRTAIMGAINVVKTGSQSLGPLLTGVLANHGFFGLSFTIAGSLKAIYDIGMLLSFAKREPARRRNVTPENGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQM8</accession>
    <name>A0A5N6TQM8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_131038</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742151">
        <property type="protein sequence ID" value="KAE8148662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQM8"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="466"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8148662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="789" mass="87225" checksum="06943DFFC31AAA82" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR54</accession>
    <name>A0A5N6TR54_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_157658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML742147">
        <property type="protein sequence ID" value="KAE8148777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR54"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025028146" description="GPI mannosyltransferase 2" evidence="13">
        <location>
            <begin position="39"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8148777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="380" mass="41567" checksum="D89AA0E862101EF9" modified="2020-04-22" version="1">MASRLALIHSGLLNPSKPLRSLSLAFGLWKALVFLVVASCPGPGYDTSTGLLPHHSTTAADVSPGNSNHVSLSILLEFVRWDSIYFIHIVENGYVFEQEWAFGYGYTRLLFLLTTSVLPQLKGLDGVTRFALVAIALSHTTHYLSVLALYKLSINIFGHDLKGNLISFLSAALHIVCPAGAFLSAPYGESLFSFLNITGYYLYSSSLLDENAGRRAISHVKLLLAAIIFSIPTTVRSNGILSGALFAYDALLQLWRMSSQGVSGVTLIRLAAIVGGGCLVGLGFIVPQWIAYTEFCMEERSVRPWCGRPIPSIYVWVQAHYWNVGFLRYWTISNLPFFILAAPMLFVLCISSIWALNATKSPDTGTSMLTRLAVPHAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRA5</accession>
    <name>A0A5N6TRA5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">BDV25DRAFT_130894</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17 26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="30">
        <location>
            <begin position="951"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="28">
        <location>
            <begin position="982"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="29">
        <location>
            <begin position="1162"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1333"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="317"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="710"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="25">
        <location>
            <begin position="951"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1336"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1395"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAE8148817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1408" mass="159357" checksum="8421862E550120A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRR6</accession>
    <name>A0A5N6TRR6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742138">
        <property type="protein sequence ID" value="KAE8149025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRR6"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024889868" evidence="1">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="374" mass="40439" checksum="BAB756E16BB3FEAE" modified="2020-04-22" version="1">MARFSVLALLPLATAKAVMPRQTACNNSPDLCSKSYGEITHLGAHDSPFLRDASTDYSTFGNQYFNTTVQLDAGVRLVSGQVHKKDSAWHMCHSSCDYLDAGKLSTWLSEIKSWLDDNKNDVVTVLLVNSDDASASDLHSQFQAANLVDYAYTPTSQTSAPTSWPTLQELISNNTRLMTFVASLDASKNTVAPYLMDEFTYIWENPYDVTSPSNFSCNPDRPANLKNDLSSALSSNRLPFMNHFLYQSVLSLEYPNSSYVGTTNAPSGGTGNLGDAASKCKEAYSRQPAFILVDFFDKGPAIMTVDNLNGVTNAVGRTNTTSATQTSSASTYSNVFKGLVELVRSAQLGANPSMGEWIWAGGDWGSLLGGGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS33</accession>
    <name>A0A5N6TS33_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_7254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="ML742135">
        <property type="protein sequence ID" value="KAE8149097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS33"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024833390" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="577" mass="64748" checksum="C5DFA3CE98964BB2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS97</accession>
    <name>A0A5N6TS97_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS97"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="553" mass="61280" checksum="8C9AC6FF0F165956" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSI2</accession>
    <name>A0A5N6TSI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSI2"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="277" mass="31691" checksum="D32DB95647C275CE" modified="2020-04-22" version="1">MTPCAQNCDSQPSSLINDSTFNRHLTLSAIAVLRRIRPLKGTVLMLTDRLCVKYGQHIDLSEAATMRFISQNTSIPVPKIFCTFIHKGCSYIVMERIKGDMIGIGWVNRSEESKTKLLIQLKNLVYEMRELQPPEGIGVSSVSRGPLFDCRLPGTSLRFGPFSSVQSFHRHLRGGMDFDPRLDCEIKELITQHNCDWPIVFTHGDLSSLNILVRGDDIVGIIDWETAGWYPSYWEYTTACQVNPQNSFWINEIDKFLTPLPDELRMEKARQKYFGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT16</accession>
    <name>A0A5N6TT16_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742121">
        <property type="protein sequence ID" value="KAE8149503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT16"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="155" mass="18006" checksum="DB1135D61E3FFF56" modified="2020-04-22" version="1">MSANNKQERQKPLEDKMGISNTRASGKELYNLFRSIAKSLDKLVASTEENSLNRIYAVAMLADLRGWAHKYNVLAEERSRSRSFDEVMNDFPAYKALMVTYFKQWEIAATAGSWETRVVQIAVKQFHYPEKSYSTLPCDKHNPIVKEADRYFWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT43</accession>
    <name>A0A5N6TT43_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT43"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000007">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="139"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="327"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="652" mass="71931" checksum="67E8AC43339AA7A9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTN6</accession>
    <name>A0A5N6TTN6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="5 15">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_140737</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="5 15"/>
    <dbReference type="EMBL" id="ML742121">
        <property type="protein sequence ID" value="KAE8149479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTN6"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF4">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025061171" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="19">
        <location>
            <begin position="17"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="17">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8149479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="363" mass="39634" checksum="DA463C1CE49CD6D3" modified="2020-04-22" version="1">MVFLPTFFTLFTLSLGRSIPRAPSPPSPYTHSSDLKIHDPTLIKVGATYYSYGVGEHIIIHQATNLAGPWAEIGSVLNNDSIIPKGDRAKPWAPTTIQVNGTFYCYYSVSNAGCRDSSIGVATSQSPGPGGWTDHGAIVESGTGKGSDEYPMTEVNAIDPAVLITEDEGYLVFGSYWSGIWEVPLSDDLISTDNKTRSNAHHLAKHPQSVDPKTEAKNPDPLCQDSSGRHPIEGAYISYHAPYYYLWASWGLCCDYDPNNLPPAGEEYSIRVGRSESPHGPFVDRKGQELTHSGGELVYGSNDDVYAPGGQGVLTVGGLDVLYYHYLNKTISYDFWEARLGYSYLGYVDGWPTVLKATDLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU47</accession>
    <name>A0A5N6TU47_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C6H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU47"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF15">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="196" mass="21994" checksum="F2523187E299A7AE" modified="2020-04-22" version="1">MGDIASDLPAKRKCLGVDCEKEAEALQCPTCLKLGMTDSFFCSQDCFKRNWAQHKSIHKTAQGKTQNGIFRTIIPPKVVSEPDPVTGLYNPFPTYSFTGSVRPVYPLSPMRTLPKSIRRPDWSETGIPKAERRLNRSKIDLLDPKGQEAMRKVCHLAREVLDITAAELRPGITTDYLDEVCHKACVERDVSLLVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUR8</accession>
    <name>A0A5N6TUR8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUR8"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29536" checksum="C59C98519966D190" modified="2020-04-22" version="1">MYLVSLALEYAAPFFLITSPVTSYADQILSIHRTRSSAGFSLDIPLIMLVASILKIFFWFGDNYALSLLVQAVIMIGVQMVLLKVALDNRPAPGLKNGLEHVPFSSAAGNGAARPYDFWQWKSAKPYWMFLAYFLAALSFIQVCLPPLAQSQFYINCLGYIGLAVEATLPLPQIIANHQSRSCSGFRVSVLAAWILGDLMKLSYFFCGSDVIPWAFRMCALFQCICDLYLGVQFWMYTKPSFGAAASPREPGDSWAVEEKDIRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUT3</accession>
    <name>A0A5N6TUT3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_118628</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUT3"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="term" value="P:chromosome segregation"/>
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        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G2-specific protein kinase NimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="397"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="473"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="549"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="641"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="322"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8150050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="694" mass="78302" checksum="7CD012CFA4B6BFA0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUX7</accession>
    <name>A0A5N6TUX7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_155158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUX7"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="125"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8150084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="390" mass="42340" checksum="0EE193B49A5A2032" modified="2020-04-22" version="1">MGSVANIPKAGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAQLDYQKIIRGAIKDIGYDASEKGFDYKTCNVLVAIEQQSPDIAQGLHYEEALEKLGAGDQGIMFGYATDETPELLPLTILLSHKLNAAMTEARNNGSISWLRPDTKTQVTIEYAHDNGAVKPVRVDTIVVSAQHSDDVSTEELRAVIKEKIIKQVIPAELLDDRTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYVARWVAKSLVNAGLARRALVQLSYAIGVAEPLSVFVETYGTSQKTSDELVEIIRNNFDLRPGVIVKELDLAKPIYFQTAKNGHFTNQSFSWEKPKALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV92</accession>
    <name>A0A5N6TV92_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_140003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV92"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="914" mass="102343" checksum="8548413F8C9A5380" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVB7</accession>
    <name>A0A5N6TVB7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_155168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVB7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="58" mass="6328" checksum="D339D979AA769FAF" modified="2020-04-22" version="1">MSLKSTMKTRWKPPMETASTAIQNHSRKSPSETSSMLSLVTLIHCQLTMIGLAGVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVF4</accession>
    <name>A0A5N6TVF4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_154576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVF4"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000082">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
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    </dbReference>
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    </dbReference>
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            <begin position="10"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150358.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="46092" checksum="AD20B677393907AE" modified="2020-04-22" version="1">MKREDITYMGAGPAPLPTDVLAKAAEALQNYEQTGLGIAEHSHRSEIANNVLNTMKADLVNFLDIPSNYEILLMQSGGSGQFDATVYNIVSVWVEKQRQKIVNERGDISEEDLVQELRKKVESELRLDYLVTGSWSSKASQEAVRLLGPEYVNVASDARKVNDGKFGKIAEESTWQLSPRPAMVYMCENETVDGVEYPKFPKRLEPTGSEEDPFVVGDFSSTILSRRIPVQNYSIIFFGAQKNLGCAGVTGVIIRKDLLIACPPAILRKLGLPVTPTVLDYTITAKNNSLYNTLPIFDVFLAGQVLKKLLATFPDKVDGQQAEAQKKADMLYGALDASPDVYKVVPEKSVRSRMNICFRVTKGGNVDDAEKAFLKGATERGITGLKGHRSVGGIRASNYNAVPVSGVEKLAAYLQEYAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWB3</accession>
    <name>A0A5N6TWB3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_154578</name>
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    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWB3"/>
    <dbReference type="OrthoDB" id="4445798at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="71" mass="7769" checksum="693B3BA31999C65F" modified="2020-04-22" version="1">MSMPMPERDPDELAEDITFENVPGVLNLGDDPANIYLPPDDDGENRDLDDANISYLGDLEDGISAMLMVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWI1</accession>
    <name>A0A5N6TWI1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_172169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWI1"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024889869" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="592"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
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        <location>
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            <end position="155"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="53"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="285"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65647" checksum="F16D625607E5EDFB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWJ1</accession>
    <name>A0A5N6TWJ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_154140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWJ1"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DDHD"/>
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    </dbReference>
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        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="753"/>
            <end position="954"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="978" mass="108822" checksum="271262AF91CC6B7C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWK1</accession>
    <name>A0A5N6TWK1_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">Ribosomal protein S17e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_154011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
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        <property type="protein sequence ID" value="KAE8150624.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="141" mass="16391" checksum="CEF512902DE09B7B" modified="2020-04-22" version="1">MGRVRTKTVKRSAKVVIERYYPKLTLDFEVNKKLCDEVAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDFSQHSETGKLDVDQDTKDLLKSIGFDSIPVNVVQVSQQQVSERPRRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWK9</accession>
    <name>A0A5N6TWK9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_105437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="860"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="955"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="963"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="997" mass="109752" checksum="60B290C2D12091D9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWV0</accession>
    <name>A0A5N6TWV0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_139457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWV0"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="40"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="41135" checksum="7CE6BA061D1B7232" modified="2020-04-22" version="1">MEIAMDPRHLFPRSGDGTQVPAVLGVSIALMAFTAVIISIRLWVRIFILRAMGTDDVFMIIGTVLTFGLSIAMIIGTKYGIGKHLGDIGEDDYAVWVTRLLYVLAIGFVKLSLLWLFIRLDRRRWMRMAVYFMIFFVAGLLVGPFFVTVLSCTPPAKFWNSEAHPEGNCMEMDAQQRFYEAHGALNIVTDIIIWLLPMPMLWTIQMSRRKKIGVSAIFGLGVLSVAAACVRYDSVLKLANNKDQYYLLADSLNWCSIELYVAIFCGSAPALSVLIRSFSPRALDSGYREQVYGSRRPPSIHACPIRAIKNLRGRQSEDVELCSQDAIITDSEPVRIMMKTEIQMEVSDAVQGYEKQVHDNFERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWX1</accession>
    <name>A0A5N6TWX1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_104446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWX1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="40110" checksum="BAB5C41F59C0A581" modified="2020-04-22" version="1">MDILLDKDAAYIAIGAAARVATSIGLQQQVKDLRLSPPEISERYIVFWCLYSFDKTLSLRLGRPPAIDDRDTEIDIPDEKQLTLENPRSITVLLSHMRLGRITSEVYSELYSARSRKYPAIKRFRTISELDRKLQDWCMSLPADIRPGSQISCSEGALRSVFTLHLEYYNCLATLHRCWAFQDPLAEYEELRNDLAHRGCGDIGDRVYSGQLICLDAARSTADLLTVLGQHGLQDSALIGLTLYHSLSAFIILFANILQNPGDSYVSKDVQLLSVIIDSLCPGLQASGAALPNLAYELLEKMRSVAVEYVARVHTNVKAAPKRPYEQTEGAVKRHPIRSAQDNHNQPPDYRHRVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWY7</accession>
    <name>A0A5N6TWY7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_104617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWY7"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="126" mass="14055" checksum="95D5989AD0583212" modified="2020-04-22" version="1">MGQRHNRRRTRPRSRNRSSKFSLIGVPPCPTINNIRTPAVFETTPAACDSLGSGSVPSAPTWHYGYTTWQKRDRTLRLEASQLGEEQCRLFGGEPGDDVGLCYRMLEYFGGLDYIDSSQSSTLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX35</accession>
    <name>A0A5N6TX35_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX35"/>
    <dbReference type="OrthoDB" id="4491580at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122941" checksum="821B25CAF50174FA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX54</accession>
    <name>A0A5N6TX54_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_153947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX54"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="339" mass="36722" checksum="51CF3E715D4064A6" modified="2020-04-22" version="1">MPSNLSIEQLKAAANQDREVTAAKAMVAEGLVSQVTMQDYQIPTQDGQMIEARTYRPSSVPATQCLPIYIHLHGGGFVFGTLSSEDAICSRIVVSLASTESPVLVVNVNYRHAPEHGYPTAWDDAEDAFHWVHDHLDEINGDGENIVIGGISAGAYLTASLTLAQNIGKNVALAQRPKVRGQVLMIPPLVTESCYASQVAQLRDPSVSSYVQCEHAPILPVNRIRLFNQLLGAASGSVLESDRRINPGLATAEEVKGLPATTFGIAGRDPLRDEGLLFAMLLNRNGVPTDVNVFRGLPHGFRRYGDKLSASKQWDEVMSQGIKRALGNSEPCEFVIKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX73</accession>
    <name>A0A5N6TX73_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX73"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="285" mass="32070" checksum="4EAFF2F2E202ADE6" modified="2020-04-22" version="1">MMLPMVSRFRTPRRRPSTTSNDSDMGNQHSAESDSPEQEEEYNPSLEDVLKTRYILRWKTTPEGLPAEIVDIIIDSAEYWPSVEVATNDASHITQDKDRVVVRTTPLCYDASTLGDSPRILAHRTAHPCRKIVFSISSHDQGFGGGGPRGSFTHSYTWFDTELVRSAHLSTTSESSLPEADDTGIRFRPGDQLLLPSQHKLQSNRTAIRDTQHYRVIWHHLDNLAADSPEAQEIEVNQGRGRATLDGSLVRSLQVGDAISVWARARFGAWVNYVERVSVRVFWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXQ8</accession>
    <name>A0A5N6TXQ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_153161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXQ8"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="61"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="342"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="461" mass="50366" checksum="226CE1DD260EA490" modified="2020-04-22" version="1">MSDYRSDITPGDRYRSAVFITAGFEKSTAESWPWIEKDTMAATSGKGSASAPDADRKHDDPSIIQKMVSATCGSVLTNLLVTPLDVVRVRLQSQSPIKNLSPFTSHTASSLKNIPPNIGVTACCREVFWVGQNSELCMVGPGAGALGGSSPAVIDCAVEETQRRTFTSTLDGLRKIARNEGVLTLWRGLSPTMMMSIPANIIYFAGYDWLRSDHRSPIKRLLPDTYVAFVAGSVARVAAASAISPIEMFRTRLQATSGTGAGHFKATLEGLHNMTKTQGYSSLWRGLTLTMWRDVPFSGLYWWGYEEVKKQLIETRKTARETLLSPGSSSVDHQQPHEADSPAFLDSFVAGAISGSVSAFITTPFDVGKTRQQVYQHMGEDALESQKGSMPKGSLPPEQQTLPKFLMHIFREEGAAGLFRGWVARCLKVAPACAIMISTYEVGKKMARDVNEKRQDHSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXS5</accession>
    <name>A0A5N6TXS5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXS5"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="52109" checksum="39D76FA314CECA09" modified="2020-04-22" version="1">MGRESVAVIDKSGKVVNTGKQLFSVFTNAKDAYLERKAQFNSERNAMLAEKEALRALEHYTLDDAPSVASSRRSRSRHHSGRSHYSRHYYDDHDYDYEDDRRSAVSRSDSHYARPQDIARRHTHHNIGTRDLDTRPPVNRSYSDAHVDMDLAYGDFHPEVLDRQPPPQQELQLQRIEDPELSGLVNRAQWLLEEADCIHHSATATIAHLQQNPNAMAAVALTLAEISNLAAKMAPSALASLKSAAPTIFALLASPQFLIAVGVGLSATVVMFGGYKIIKQIAGNKTEVSKAPGAQGPGPEGPESMDDMVEINTECLSSVEMWRRGVADAAGDSVGTSVDGEFITPTAAMMSGIDVTTARMVRDPRFKFDDEQSQASSHRSRRSHSSRSHHKRPESQAPSKAPTKSIFGIPSKAPSKAPSKAPSKAPSKAPSKAPSRAPSHAPSRSSSKADSHYSDKDKNPKEKKSRTSKLRLMFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXW3</accession>
    <name>A0A5N6TXW3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_98818</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 11"/>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXW3"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="246"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8151218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="602" mass="68828" checksum="3D5617FC77D6FC3F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY30</accession>
    <name>A0A5N6TY30_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY30"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27881" checksum="DBC54F7C8343171B" modified="2020-04-22" version="1">MATQVSLMTYLQHGPPALPIIEQGQSPQNTRNDRYGAGDINNYGAVLAAARIADEPFQPSPPRPINSETAVRSRIDSYLTDRIIRALRCGFSHMQSTQQLGNFTIVHYDVGTMAATIENHTPDFAFFDNNLEPKIRPNRGPGDAKPSYKWSLDMRNNHNPSIRLEFKQVLSQVNFYMMQHHARYGFIITDRELVAVRRLDRNGNLELSASISWTMKGTASQPRLTVLLAIWYLGMLTANNQGWYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYI7</accession>
    <name>A0A5N6TYI7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative copper/iron-regulated glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYI7"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26938" checksum="A777F5FAFA3FF8F3" modified="2020-04-22" version="1">MGSMDTLRIAVLINTPPDNMEFWLDVRESWKSAFATISPTAQVDLYDPVIERQFPDASKYNLIVLSGGKADASSSEPWVLGVLNYVKSTARDLPDTKIIGICWGHQAVNRALGGVVRAVPTGPIAAIEEICLTEAGKTFFPFAVTTGTYKAPEFHVREVATPAPGFIHLAENHECFVNEANSILTFQGHPELSKQLVKKMLLEEDKEYNGNLSPEQLEKEVRKLDQPMDGVKLLERVIQWVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYV0</accession>
    <name>A0A5N6TYV0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_90429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYV0"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="51542" checksum="16EAD7F6A9026EA6" modified="2020-04-22" version="1">MKDGRQLVAKIPNPNAGLPFLTTASEVATMDFVRTVAGIPAPKVYAWSAHANNTVGAEYIIMEKAEGVLLSTRWPSMSMEEKHQLIQSIIGFERSLLAHPFGSIGGIYYEKDTANMQNNSLPDAYTGYCVGPTPDRKFLEDGRRNFQTDKGPWNSTTDYILASTQRERQCIQQSRRFPRPEGIFGGPHSYQPTVEGKIGVLNDFEKVVPFLIPKDHNVTMPVLWHSDLHHDNIFVDPKTPSKVLAIIDWQSAHIAPLFQQVITPAFLDFEGPRPNEGLSAPSLPESFEELPPVEQQRAKALRSQQSLFKLYEIQSARGNRPVFNTLQACNTLGCQIISLASQVYNDGETVIRGQLMQLAEDWKQLHGNSGVPCPLVYTTDDISKHEVDQLKWEEGVQLMEDVLDSLGGAENGWQGWVSHDDYDQMKKKLEIVKGQFLDHMATGHGEREAWAKAWPFQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZD5</accession>
    <name>A0A5N6TZD5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZD5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="76" mass="8260" checksum="1D578A7C60534FA0" modified="2020-04-22" version="1" fragment="single">MLGAKSTPTDKIVTVLSPSQDLKAIFESINIEAQNIVSTCTSGEPATAFDLQIDPGPIMEEAKRLYQKVWHDATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZV8</accession>
    <name>A0A5N6TZV8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_151955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZV8"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031596493" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="521" mass="57803" checksum="706DB4ABB8BEBD07" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZX2</accession>
    <name>A0A5N6TZX2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_151931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZX2"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="111" mass="11925" checksum="EE27C11FD1DAEC13" modified="2020-04-22" version="1">MSDKIEKLDRAMSEALAALQAHPSATHPTVFYVFDFVRNSHNKLKAIDANKLQAGDRAAKEEMSDIVGRNALAEGLCSGEGPMAQMMAMMGGGSVDFGPEVREKLRAVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0I7</accession>
    <name>A0A5N6U0I7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_152265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0I7"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28053" checksum="F84ACBFB8FB4BC21" modified="2020-04-22" version="1">MGFGGVLLRFSNLAIRVLQFLDAAVILGVFSFFLAVLSRHDQNIPQWMKATEGLSGAATLYGLLGILFTCCLGGVAFFAVLAIVLDVCFVGAMIAIAIMTRDGTQKCEGRVDTPLGSGDSNAESASKVKFEFACELQKVTFAVSIIGIFFFLISILFQILYARHHKREKRFGPSPANDYTYGSRPGLAFWRRKKNNPDAASADDMLPNHPTPQDVELGAHSEKSSGLGSMFSRNRNSTHAPGTVPNGYGYGNSAYTGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0U4</accession>
    <name>A0A5N6U0U4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_151882</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0U4"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="453"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="550"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8151979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="756" mass="83357" checksum="02DC95140E90DB45" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U150</accession>
    <name>A0A5N6U150_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_151221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U150"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="300" mass="33176" checksum="C272DE0B3007F85B" modified="2020-04-22" version="1">MSMRIVLFPCKNIANLGQVIIHAGAGWHTPSAKALIRGQGVRRQNTNNDVHYIQISGTSNLSDRPYTKGYIDTHVFPDEEDIYSYEKYRESGETYFQRTADIAVIEEGEASGVTTYIVMAPTIFGLGSGPFNCFSMQLPTMIADALRTGSCSVVSEGDTIWNHVHIEDLAALHLILLQHIHRGIKIPSGRKGIYFCESGEHSHREFSECLAKAGHKSGVFPSSEVAKITIQEAGQKWVFGNTSSAELGFASNARTKAVLARNLGWVPSHAEEWESTFSTELNEFIKSPPTGREVPKYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U171</accession>
    <name>A0A5N6U171_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U171"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969600" evidence="1">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="17210" checksum="B5BC84D06EA6A957" modified="2020-04-22" version="1">MRAAVFFGIGEFLLQILQALQDISIAYPVAAVVDGDDYFYGISLHSTVTGRAQAYGSFPARERQVQGRALEHPAAVEAVFADIKLRGETRRAIPGFPILPITCEIARGDTSPGEIGSWSRSSAMKRELPLDIARTAAGRIDHSHQASEEALCHLSMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U181</accession>
    <name>A0A5N6U181_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_137929</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U181"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="57"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8152355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="298" mass="33319" checksum="28B6C2AF89F295C9" modified="2020-04-22" version="1">MDEKQTKEYCISGDSKELPLGTQQNTTSNIPAASSRTPDPSRHVETIIVREYLPPGVSRIIACGAGCFIGYIDESTVLKYPCVPNHKFLKTEESLEVEAQILDTLGKHPRIIGSKGLNEHGLLLHYLPNGSLYDHVNAHADIPLDQKLRWCRQAAEAVQYIHSKNVLHCDISLRNFLLDDDFNILLADFEGVLKSPDGYTLLDGLARNGVKAYPPSADCGCVNVKTDIFALGSAIYFIMMGHDVFPELNDVHDEEEIESRFRDGLFPTDTHLYCEISERCWKGYYTSAKEVLSDIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1C5</accession>
    <name>A0A5N6U1C5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_67180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1C5"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="10">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="56597" checksum="3B2B9A37CA8A6923" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U250</accession>
    <name>A0A5N6U250_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_170011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U250"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="279" mass="31902" checksum="8187903E63E34B7F" modified="2020-04-22" version="1">MTDISEGVPFRTQNLQEGNGYIKRGQTLFPCPSSVVTVLGKPMGRIILEYDFSLVTKSGHGVRPAEAEAMRLISRYTTVPVPKVYHTNFSSEYDGFIEMSLVQGFPLEGTWDTMDEKRKESICRQTWDLISEIRSVPSQHEGIFQCAADGSPSKDPLLEDLQSPPRPLTSDSDLRARIYERYLHCGGSRYEHELPNMLPKSDHAVFAHGDIAPRNIMIDENGNITGIIDWEYAGWYPDYWEYAQIMRPAFWGDWSIWMERTAPERWNLSGINASRKVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U295</accession>
    <name>A0A5N6U295_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase kinae kinase bck1</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_57663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
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        <property type="protein sequence ID" value="KAE8152706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1247"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
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        </location>
    </feature>
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        </location>
    </feature>
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            <position position="1348"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1571" mass="170974" checksum="2CEB280725D2FBD7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2I7</accession>
    <name>A0A5N6U2I7_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_52768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="139"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="689" mass="77679" checksum="F461937F256DD152" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2J5</accession>
    <name>A0A5N6U2J5_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">BDV25DRAFT_128008</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
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        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Origin recognition complex subunit Orc5, putative"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
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        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="564"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="657"/>
            <end position="693"/>
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    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
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            <end position="801"/>
        </location>
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    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="802"/>
            <end position="837"/>
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        <location>
            <begin position="838"/>
            <end position="875"/>
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        <location>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1492" mass="162952" checksum="766CA9D783E2F84A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2P3</accession>
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        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="19" type="ORF">BDV25DRAFT_150477</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05730">
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00747">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024837346" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8152848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="275" mass="25192" checksum="C3A219FA1938F068" modified="2020-04-22" version="1">MKTTLLSMALLAAASVVSADVSVGECAQMCISNMNNKASELGCKSGDLACLCNSQNYSYGVRDCTSQACPNDDSAAVVAAALAACPNGSGSSATASGSDSTSTGTGAGAGGSTKTGDSASATGTGASKTGDSASATGTGASATGTGASATGTGASATGTESGASKTGNSASATGTDASKTGESASATGTKTGDSSSSTANSSTTLSTSASSTTDGSSSETGSSGSSTDGSNGGSATQTGSSGSSTDAPDSDSAASKTVVGSGAMGAFALAAFFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3J7</accession>
    <name>A0A5N6U3J7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PI31 proteasome regulator N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_149865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3J7"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8153207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="351" mass="37474" checksum="59C332B39B2E1DD9" modified="2020-04-22" version="1">MAENLDVLRVESVLELANQALRRDDNETTLQTPYEAIALIGHACMSAVNFRLVGLGEDHTIESSDSPSLPREWNANDAFSFRYAHPQSAMQYLLKVSRIGNNALIFALALGDDKTTTFDIPVKDFVSTSALPRPPSTASLSDVFISTSRLTDLIALFKINVIQKLAPGVYKEGYEDTSRTVREPAQERPPRHDPLRDDPIPQPARPYPFDDPLAAAPRRPIPPGDFAPPGFEDEFEIQRPPRGYPGMGGRHPLNIGDRDLYPAGLGPHDPLRGGVGPGIGPGFGGGGMHPTFDDPLFGGPQGGGYDPQAPPGSRYDPVGPGGPPFGRGRGPYGGRGAGGGFGGFGFGGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U460</accession>
    <name>A0A5N6U460_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_137272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U460"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024988828" evidence="2">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="206" mass="22231" checksum="ABB2238024D7938C" modified="2020-04-22" version="1">MPKAIVFDLLTALLDSWTLWTSATNDPETALTWRKEYLRLTFSCGVYKPYSELVHASARNVGLPSSAADTLLSTWDSIRPWPETRAVLVRLKELGYRVGVVSNCSRELGHRAAGKCGVEFDAVVTAEEAGFYKPAPEAYGAVLREMGVEAEEVVFAAGSNGDVVGAGEVGMDVVWHNRIGLEGLPGRGASIEGRELGVVLEYLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Y3</accession>
    <name>A0A5N6U4Y3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_148962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Y3"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024993492" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="237" mass="25911" checksum="88555EFBEB3494D4" modified="2020-04-22" version="1">MQLGKIFQVIALLGASMPVLAWNRINKDDAALLVIDHQVGLAQLVRDYSTNDFRNNMLAHAAIGNVFDLPTVLTTSSDQGPNGLLLKEIRDMHPNATLVQRQGEVNAWDNEEFRAAVKATGKKQLIIGGIVTEVCTAFLALSLVDEGYEVYANTEASGTFDPRLAEDANRRMEKAGVTLMGIFGIVTDLMRDWRSTPGLTEVLPMLDKYQFAYGLVARHHAGAIQNGTLAAVEETLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Y5</accession>
    <name>A0A5N6U4Y5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-PSP endoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Y5"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="135" mass="15325" checksum="9AAF6E8005F3E1BE" modified="2020-04-22" version="1">MSHLTYYSYEGVGQKNKATFRYSQAVRLSDRIECAGQGGWNPQTGVIHKEINAQIDQAFANVELNLKDAGGKGWEQVFRVNSYHVPINNEALDAMVRNFKKYMPNHEPIWTCVGVSRLGEDDMRVEIEVVAHDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U669</accession>
    <name>A0A5N6U669_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_168168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U669"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114096" checksum="DE5AA54677B245DF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6M9</accession>
    <name>A0A5N6U6M9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6M9"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="348" mass="39410" checksum="6901237E6B16F549" modified="2020-04-22" version="1">MNDQRITEATSTELDPDGDILMTVISPSKAPAYISRTNQKRSQRIFKVSSRSLVLASSYFAATFGGFWGEQGTLNRDGLLEMAINDTDPDAFEILLLLMHGKTGHLPGRLDLDRLLEVTVLAGLYHCREIAAGPGRTWLAILGRGRYGLHDIPKYIFLSWEYNRIDYFWNLTYHAKNYGPRPFDTLGLPIAQEIIEAINKPRDILITGISRTFMWYRAEIIHDPTQMSCSKCAEKILDWLNRNLGILVASVICPTPDNPGASIDEIFRRLALSESEWSRKWELKGRVGRGIYTSYRETCPGDCISLFKVGIRIQLPDWKKLLKGIRLGVVQNRIADGHFFAGFTLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6N6</accession>
    <name>A0A5N6U6N6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ppx/GppA phosphatase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6N6"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000007">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="3">
        <location>
            <begin position="436"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="661" mass="73803" checksum="F9F6FB94FC3189EF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6V6</accession>
    <name>A0A5N6U6V6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_115493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6V6"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="298" mass="33474" checksum="D169774940706F03" modified="2020-04-22" version="1">MDFTFHPGVNGSDPWVEFFPYNPSKPAGYAFVVLFGLATVTHIVLMFPFKAAYFIPLILGGICETFGYYGRAWAHNRTTAIDSWSLQQMLILCAPTFIAATIYMVLGRIIRSFNAEHLSPMGTKKITVIFVLNDVICFFTQLGGAGVQITGDQQVMDIGRKVVLVGLIFALVVFMVFVWVAAVFHRRLSAYPTPVIMENQLNWKRYMWAIYVSCFVLMVRNLVRLVEFAAVKSALNQKEVYIYVFDAFMMFVSVVVLLVWHPGLLIKRARNAGKAGVMCASMEQGSGVPLTGYADRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7H7</accession>
    <name>A0A5N6U7H7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="6 12">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_102825</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="6 12"/>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7H7"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000028">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024803268" description="Alpha-galactosidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="17">
        <location>
            <begin position="60"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="16">
        <location>
            <begin position="671"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="506"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8154556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="749" mass="82649" checksum="09C73E8FD881A7F5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7I3</accession>
    <name>A0A5N6U7I3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_126569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7I3"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="442" mass="49828" checksum="E1616CBAD5F40ADC" modified="2020-04-22" version="1">MGRTKPIEPELTIHFTEPAVFVPTYTNKPAVLRGCCVLKVKEPLIVKRLTVNFRGVSQVHWPHGLHDTKTVTNRSLTVFGPDITETGIEYHDDRECTTNTCRTSNNTSLPKTRLWNNILNRLSKNAAPPGCQSLSPGTYSYDFEMVLPPQLPESVDIRRGHVRYTVRARVECPGPFKHNIVQNKPIAVIHCPAEDFVEDAEPVYITRAWKRLLRCDILISRRGAPLCHRLPITVSFTELANARFHGLQIFLSENVQFLRKDGLVSCLGPFKRRLLYQAGDDLVSTLLPYLSNDGEEGQGGEEKVGYLGLEDVKRSDCAGKTADCEGMTLDIDLPLPNCQDHGQLDWMHFSTEYKSVRVNHWLEFVFSLSRYGAPIESGVPVVQKIARAPLSLRSCYAEQTNASLPAYSQTCDLKQSCAISSTETLELDQHWWMEEGHRYSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7K2</accession>
    <name>A0A5N6U7K2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_103068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7K2"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024857224" evidence="5">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="32"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="410" mass="46152" checksum="360B40F376188294" modified="2020-04-22" version="1">MRLLSALALFIAPRIAGAISTGPLSTEGRWIVDSNGENVTFAGVNWPGAADAMLPEGLQYQSIEYIVSKIKSLGMNVVRLTFATEMIDDIYEKGSDTSIEDSLVNALGNDNGTAVYREIVKHNSQLGGNTTRLQVFDAVADECYRQGIYVHLDNHISKGMWCCDTNDGNSWFGDKYFDVENWYRGWRYMAEHVKSLPAVKSVGMRNELRSPDSNSDLVDKTYNWQYWYKHMVENANQIHDVNPDVLIYFSGLNYDTILTPIPTGADLGNGTKFLKDDFSYGDKIVLELHNYDRTATSCDDLKSGLWNGGFNALDTTNSSIVNTFPVQMTEFGFPQDNTTYTDVYASCLREWLPEIQAGWMVWVIAGSYYIREGVQDDEELWGLLDHTWSDWRSPAAINNGLKRMVEATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U830</accession>
    <name>A0A5N6U830_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_147000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U830"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8154793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="37766" checksum="EB597597732B8E4E" modified="2020-04-22" version="1">MAPINIMTRLKSLYTKSYDEPVISTQTAVFFSICLTLLYVVPFYISSTTRPSLTLSRDAPSVIRARIKAVTLSCIVSTLAVSWLITTKNNVSFPGTFKLLGWWPIGFPEIIRSLLLTAILFAGPLYESGIAEGEWRDWIKGRRVYETLYGWIGWRNYVAGPITEEVMFRSVIIPLHILSKMSSGRIVFMAPLYFGIAHVHHFYEFRLTHPDTSILAALLRSIIQFGYTTIFGWYATFLYLRTGSLPAVILAHAFCNWCGLPRFWGRVEARVPIGSPPVKGKNDSDRAPIYAYGPLSIGWTIAYYLILVGGAIGFYYALWPLTESPNALVAFNRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8C8</accession>
    <name>A0A5N6U8C8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8C8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="344" mass="37687" checksum="7F4902E3272F5C2C" modified="2020-04-22" version="1">MTRETILITGASGFIATHVVNAFLRAGYAVRGTVRSEEKAAKVHRTFSEYSERLSFVIVPDIAQPYAFDEAVQGVVGVIHTACPFKAEVEDKERDLLQPSVLGTFNILNSIQKYAPQVRRVVETSSFAGMLDISKGNWPGHVYSEADWNPMTYAEATNANTPDIATYCAGKAMAERAAWDFMARENPPFDLVTICPPCVYGPNANATADLVKLNTSSAEIYQLMSPMSKPSDPLPPPVVWVWVDVRDVAEAHLKAFEVPEAGGQRFLVSAGNHSSQKIADILRDHVAEVQDRVPLGKPHSGMGGREVYGVDASKSEKVLGLRYHPLEETVVDAARAFLRLEQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8W3</accession>
    <name>A0A5N6U8W3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8W3"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8155026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="656" mass="74174" checksum="F492CB2A5FB84018" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U920</accession>
    <name>A0A5N6U920_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U920"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26735" checksum="EDA58DDC888CD9FD" modified="2020-04-22" version="1">MNLQHISSPRMTRETARDRFLLPCGPLALLCIFIFLAASRLLPPVSPSKSPEDLVAHYSQNKSAIDAGVFLCLVGSILWPLYTVAINNQLSRIPGIHPTILSLQTASGAVSGATILLIGIFFAAATYRLDRDPVVTELASDLAWLAYTFASTPWFVQEAVLSWGICCDYRAKPLIPHWVAWVNAGLSLSWIPTYATHIVHDGPLAWNGGYTFWVPWGTSGIMYTLVTIYFWKAAGIVDGGEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U924</accession>
    <name>A0A5N6U924_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U924"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="34808" checksum="715A162EAAF23BE0" modified="2020-04-22" version="1">MPLRIPRYLLTTISRPQLITLSDPLRRHFSITPNQDMKIAITGARGTVGRAVVKAAADAGHATVQVDRTDTEYDGTPNSEMKTADTANDFDATLNAFRGCDAVIHLAAIPSPIDKGDDLVHNNNVNSSFNGFRAAAELGIRRFCYASSVNAIGLEYATRPLNFDYFPVDEEAPQRPTDSYALAKDEAESQARAFARWYPGMNIACMRIHAVAPRSEAQKGQLENWDSAAVKSLWGWVSAQATARACLLAVEKAEKLNGTEVFNVVAPTTTQDIPSRELAQKYYPDAEIRGELSGNQSFFTTEKAKRILGWVHEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U963</accession>
    <name>A0A5N6U963_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_38013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U963"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="52030" checksum="1F7570F2C5FA7A17" modified="2020-04-22" version="1">MQEPIANGSTPAANVPIGGNLPVDNPGECFWQTQPHPKSDYRSTEQLPEHSDIVIIGAGYAGISTAYHLLNDFKNANRSITILEARGVCSGATGRNGGHLRPDFYGHIPTYIDRAGKRAGAEIAEFEIAHLPSLKKVIEAEKIDCDFTLARTVDVWCNEEAAAKAKATFDKMVAHNFEYMNDAIFYTGKDVEGICGVKGAVACASYTAGTVWPYKFIMHLTDSILDTGKVNLQTHTPATSITPGSNGSYTIHTQRGKVHAGTVIHANNAYVAGLLPEYAKNIIPCKGICCRITVPEGTTAPLLNNSYINRTEDNTLSYLIPRADGSIIVGGAAAKFRPFKDQWYNNVDDSVLIDSAKDYYDGYMQRTYRGWENSGAKVDKIWTGVMGYSYDSNPHIGEVPAKEDQYIIAGFNGHGMPVIWLAAQELAKMVIQGIPFEKTSMPRLFQTSQFRIDRAQNGKEEDGDILGTGNFPATKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDI6</accession>
    <name>A0A5N6TDI6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_95366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="ML742524">
        <property type="protein sequence ID" value="KAE8144443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDI6"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8144443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="274" mass="29290" checksum="ECF65F3D64C242F7" modified="2020-04-22" version="1">MTQPRDALSFPPSNRSFLEPHLPQNEPTSDLPFTTLTFATSLDSSLALAPGTRTVLSGPQSKAMTHYLRSRHDAILIGVGTAVADNPGLNCRIEGVGGYGGSGLTGQPRPIVVDPRARWEFTETSKILELVHEGKGRAPYIMISAQTSPSPEKRELLERYGGKFIPLELTTTVSGGSEIDWGVLLRRLREEGLQSVMIEGGGTIINSLLGPDSAPLVDSVIVTIAPTWLGQGGVVVSPPRRMDGSGHPIAASRLTGVQWYPFGEDVVLCGRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDN0</accession>
    <name>A0A5N6TDN0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_97122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742546">
        <property type="protein sequence ID" value="KAE8144376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDN0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024998838" evidence="2">
        <location>
            <begin position="24"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="668" mass="62786" checksum="E4BEC2C3D87DC314" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDR8</accession>
    <name>A0A5N6TDR8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_167165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ML742579">
        <property type="protein sequence ID" value="KAE8144299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDR8"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025091643" description="Peptidyl-prolyl cis-trans isomerase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="207" mass="22949" checksum="0A28B720B24C5871" modified="2020-04-22" version="1">MNFRNFFLSLFFVLAVGLALVHAEEAKPRGPKITNKVYFDVQHGDKPLGRIVLGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKDFMIQGGDFTRGDGTGGKSIYGEKFKDENFKIRHTRKGLLSMANAGKDTNGSQFFITTAITSWLDGRHVVFGEVLEGYEFVEAIENVPKNPGDKPKEVVKIVKSGELEVTEKGSHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE47</accession>
    <name>A0A5N6TE47_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_145409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742464">
        <property type="protein sequence ID" value="KAE8144653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE47"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="172" mass="18588" checksum="5FB0932A929BB7BA" modified="2020-04-22" version="1">MSDDAYMAFLDKASADLKEARSRLPPDADEVRTETVEIGVRIPAPLASINSFYISETDEPFEPVTLRWEGASKGVFPDPSHFSSLISPRTDLSSSITTLPASSFDPHNQYSSVLRAVRAAATEASGGGIDESAVEVKVYRVETGTSRVEYYVLALNVEDSLLVGLKAKAVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF74</accession>
    <name>A0A5N6TF74_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_165531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="ML742397">
        <property type="protein sequence ID" value="KAE8145034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF74"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8145034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="244" mass="27159" checksum="25D0AE1156F8DED8" modified="2020-04-22" version="1">MAIRAPFIVPALKKHTATVIMAHGLGDSGAGWMGLAQNWRRRGMFEEVTFIFPNAPMIPITVNFGMSMPGWYDISKLGSDLDFEETLRSQDEAGIIRSRDYFNTLIKEQIDQGIKPSRIVLGGFSQGGAMSVFTGVTNKEKLGGVFGLSCYLLLSDRIKNYIPEDWPNKKTPFFLAHGEDDEVVKYNFGKMSSTMLENIGLEDVKFKSYSDLGHSADPQEIEDLEKFLQQTLPAEKTSDESAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFF3</accession>
    <name>A0A5N6TFF3_ASPAV</name>
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        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit Ribophorin II-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_77286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742386">
        <property type="protein sequence ID" value="KAE8145105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFF3"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044283181" evidence="8">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="30776" checksum="A5CD9F164B96D218" modified="2020-04-22" version="1">MQLWHSVLQLSLLVFTAAPTAAASAWGFADATVSVHTKGAGVGAGFKETIPDNKALSKPVSLGSTDTLKVSLTARDGSSATRAHQVFLFLQDPETGLDISYPFNVKDNGKSKVELTQKDLPVQFLSVSEPLDARFLIGSFGSSEAYNGAAFKLAVTRNPDHPVPTVEVSRYGKLPEIHHIFKDGPSSPPIVITLTFVAMVLAALPILAGVWITLGANVCHLPKAFKSSPISHAVFLGSLLSIEGIFFLYYKSWTLFQILPAVAAVGTVAFISGSRALGEVQGRRLDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFN7</accession>
    <name>A0A5N6TFN7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_134248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742415">
        <property type="protein sequence ID" value="KAE8144911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFN7"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="712" mass="77370" checksum="4FA01B75DFDE871D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFU6</accession>
    <name>A0A5N6TFU6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_133964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742368">
        <property type="protein sequence ID" value="KAE8145244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFU6"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="854" mass="94922" checksum="8BB65E3ED443025A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG47</accession>
    <name>A0A5N6TG47_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_144782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742362">
        <property type="protein sequence ID" value="KAE8145302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG47"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="514" mass="57161" checksum="646CA7F189563750" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGA1</accession>
    <name>A0A5N6TGA1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742349">
        <property type="protein sequence ID" value="KAE8145408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGA1"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="333" mass="36252" checksum="FA3CCA393B2C37BB" modified="2020-04-22" version="1">MTFTPDSEFSSLETPRISTGHLSITALCRFEFEPGKGNEGTKILMLEWEDDDLSRSAEAGTWRVRWEGKQGLSVCDSTASDGHDESNENIRRVYFLLPPSVTIPPVVTLSYEPNGDCAVSVPRHDLHLHPLPAIFPPELLAEGRAAGKGVLHTIWAKRRLQELEREIREESRNVEGVALHMAIREKEWIELNFGVGCASGSGSGSGSGSLDKAEQRSTERYPMGPTTPVSPSTGGKLGEKLKGLRLQTSPRELSGRLLSPQSPDMAVFQPRTVAHYPPAMQSVEGTGFTSIAGPGLGPGPQTNEGEDLFAKALSPRSPDLPRSPFSFAPERVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGE6</accession>
    <name>A0A5N6TGE6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_164778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742350">
        <property type="protein sequence ID" value="KAE8145396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGE6"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41576" checksum="0626B16EA4955287" modified="2020-04-22" version="1">MNIISSAIAGLLAMVLGLIERIIQYILRVDDKKLYSLDHVILSMEVPPQSMWMNMGYWKDTTSFKEASKALLDQVLIAAKLLNEDGTPIEHHSQADVIKLVDVGIGCGDQSLYLTRKVIGVTTFSDRRPPISPRGIDPTAHGIDNSYNGKTRPLFDSYVGVTLIQCQADFARERLMKSTKEPSIASDTTANVEIFVADAANPSSWSPDLQESVLDHHGSTKPKRAQTWLLALDTLYHYKPSRDPLLRYAHETMQASFMAFDLLISDSASTWHKLILRLMCLVSGIPFSNFLTREEYEAQLVRAGYALDQIEMRDISEHVFAGIAGYIRRQDAELKKYGMTVGKFKGAAKAFGWWARTGLVRGYVVVARKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGL7</accession>
    <name>A0A5N6TGL7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_70895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742345">
        <property type="protein sequence ID" value="KAE8145447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGL7"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000042">
        <property type="entry name" value="Putative exoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="386" mass="41378" checksum="B039202A4150280E" modified="2020-04-22" version="1">MAAQRQASSASQTPHISPAELSYLYTSLALPGSPIRPDGRSPTQFRPLTAETDILPGTNGSARVGFADGTQAIVGVKAEVEKTVVTADALKLPQQAKDDYAGNEDGDGNQGSSTGHGSWVQMSIEIPGFRDDDALPVFLSEMMREPLVESVSNGGSGNDEMAGGLKKRLVINKRWHWRLYIDVLLLSQPQSYPLPLLSLTTHLALLSTRLPKLKSKGEEDPFFDDDWGAAEYIYPRALKSKSHLSPSHQVRPPVTLLVISVGENVIFDPSREEIAVADTVLAVSVARDSDSDTLKLLSMRTIDPPSRLTQPGVANSENVATLGSTAAAEEAAILNPSTGEEEVPGVWRPRRGGVKRSTIARMVKLVLQKGGVGEEVLEGLEGVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THD4</accession>
    <name>A0A5N6THD4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742318">
        <property type="protein sequence ID" value="KAE8145732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THD4"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="122" mass="13365" checksum="3556B6E1D342EE45" modified="2020-04-22" version="1">MARHTSLDSERPIMAPSNRASKRFSTVSGNPSIASSGTLGSIPSGDPRLADFHHLRDGLERLENKPLQKQRFVPTPEKSDDLSKLALSAKVERALDRRMTSQDAVMRKPVLSEKPAIESTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THF9</accession>
    <name>A0A5N6THF9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742315">
        <property type="protein sequence ID" value="KAE8145762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THF9"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="381" mass="42112" checksum="5392456B6B924D56" modified="2020-04-22" version="1">MVDDSNQRIALGVIVAFPVLGGIAMLLRFWGRYLSRSALQSDDYFIIMGYILGIGQAVTMWYYVKTNYTGIHFWDIPKDYDRKEGLIWNFATQLLYNPCLTMVKISLLLFFRRLESRSRLINSLIWGTLAFTIALFFAVLFVDIFQCSPVAYVYDQSISGGQCINQGAFYVSTAALNLFTDFLVVSIPILITWSLHMPIRRKIAVCVILCMGGVATVIGIWRLVILAKGFFPSSPPTDPTYDIGFCSSAVEVHVAVMAACAPSMKAIVSKYIPHLLGTSRNGGTSRYGTASASNRFRSGYGHSRPKSKAGDAFELAGPYRAAVDPTAEEREMRKYRRGDSPSLSSEEGGIVKTTDVEVQYSPGHPHSHVEEGRAASVDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THR6</accession>
    <name>A0A5N6THR6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_163658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742305">
        <property type="protein sequence ID" value="KAE8145873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THR6"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000021">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="100"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="295"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="50886" checksum="43D184AF8C541D43" modified="2020-04-22" version="1">MYTDLCTAPKNFRSIFRSHTWGSRRTMTGLSRNSSDEPTERDALINGPNRANSGLKHRTWSYWPLRVVHLTWATIIRDYVNVLLIFVPLGIIAGALHWDSTAVFTLNFLAIVPLASLLSFATEELAEAMGQALGGLMNATFGNAVELIVSIIALKNGQIRVVQASMLGSILSNILLVLGCCFFIGGIRYSEQSFNTTVASTMSSLMTVASASLIIPATLYASLSSATGPVEREKNILILSHGTAIILLILYVMYLYFQLKSHASLFEECTPDAESQDTQVAEEDEHLLNPWAASVALVVVTILVAVCADYLVGSIDNIVEKTGMSRTFIGLILIPIVGNAAEHVTAVVVAWKGKMDLAIGVAIGSSLQIALFVTPFLVILGWILNVGMTLHFHIFETVAFFISGLVVTFLIQDGKSNYLEGGLCLGMYVNLPSPFSLSLVNLSFRYVILALAFYVYPDTATDDALFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI85</accession>
    <name>A0A5N6TI85_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_56770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742290">
        <property type="protein sequence ID" value="KAE8146055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI85"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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        </source>
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    <sequence length="520" mass="58384" checksum="DE156009F23D8DD8" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Henrissat B."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJY1</accession>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJY1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="100"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="424"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="653" mass="71819" checksum="00A3868DF34EC7D4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKA5</accession>
    <name>A0A5N6TKA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rec8 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_132679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742244">
        <property type="protein sequence ID" value="KAE8146755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKA5"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="681" mass="74832" checksum="D82F8CBC65CBC0DE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKF0</accession>
    <name>A0A5N6TKF0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_132816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742254">
        <property type="protein sequence ID" value="KAE8146571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKF0"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="26075" checksum="AA0C2B31820CF2F1" modified="2020-04-22" version="1">MSYLSHELSRLHNKVAIITGGAGSFGTGIATKFIQEEAKVVIADLDNTAGTEIAGRLNCTFFQGDITQRAGWEKLFETAIHVYGGLDIVELAEDEFEKLVNTNMKSLYLSTSITIPYFLERRQPAVFVNIASATARRPRPMLTWYGATKAAMLNAVNSMAVEYAERQIHFNTINPAAVLTRMTKGLLSDPAVERKYLDTIPMNRLCQPADVANAACYLASEEAGFITGACLDVDGGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL36</accession>
    <name>A0A5N6TL36_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_43055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8146990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL36"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="150" mass="17367" checksum="1068D9497DDE005C" modified="2020-04-22" version="1">MLAPRKLHRTRCPLVQQCHVSLDDASFESALERLVCPVQNLSMSSFSEGLYQRQWPTKYPLSRNVRSCHRFFPTYKLLVLSFPPVEIFCFATVNRLYPTVEELHATGPCYYPYLEDAGPSGGKRPHILLMIQAWIMFEIEESYSVFTICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">BDV25DRAFT_142918</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="EMBL" id="ML742216">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000652">
        <property type="entry name" value="Related to VPS15-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
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            <end position="1182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
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            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1540"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
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            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
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            <end position="1559"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1608" mass="179049" checksum="BC2AC3FE5A22A2DB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLQ6</accession>
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        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024861842" description="Mid2 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38914" checksum="16EE3DC53AB8BA33" modified="2020-04-22" version="1">MHFFHILHPTLSILTLLAWFQHTVASPLDFDETSLEKRCANPCGYYSQLCCSSNQKCSTNSDGQAQCVDANSGGSWEYYTTTYLVTETDVSTVTSTWSSYLSATTTAGGSGSCKAELGETICGNTCCGAAYVCSNNQCIVGSSSIWATATATPPVRGTSASTVTATASVTTTQGFVAPVGTNGATLIGEKAPDEGGLSGGAIAGIVIGTIAGVFLLLLLCACLCCRGALEALFACLGLGGQRRRKDTTYVEERYSHHAHGGRPEGRTWFGSRPPAPASAPGEKKKWGGLATLGIMLGALALCLGLKRRRDHEDEKSDYTYPSSYYYSDYYTSASSASSDRRTRDTRRTRDTRQTRRSRTRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLV2</accession>
    <name>A0A5N6TLV2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLV2"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26697" checksum="8AC71270203FF7EC" modified="2020-04-22" version="1">MSFRPMFQQRAVAPIAATLMAGGVAFYPRRTAFAEEPKNRKPIYDDFPVDIPEPTKTLPSPPKLSTPPSSSSPTPTDILTAQVRQARLFLYENSLAAENCFNDFLSRALHIENAFTNTVASLAPSPESGEQLTPGGVYVVVSAMAGSIVSRNRGILLRTASPLAFGTAAAWTLLPVTMRNISDLVWEYEKKVPAVAEQHLYLRERAEHIWSTGIAHSGMARAMMEEKIGETRKKLEELVSKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM81</accession>
    <name>A0A5N6TM81_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_132069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM81"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000055">
        <property type="entry name" value="Bifunctional fatty acid transporter/acyl-CoA synthetase (FAT1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="623" mass="69680" checksum="52904452C3C1AFA4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TML9</accession>
    <name>A0A5N6TML9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor nbp35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">BDV25DRAFT_30100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TML9"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="325" mass="34473" checksum="7C2B81DB09DB968C" modified="2020-04-22" version="1">MSPSLVAPEPEHCPGPESQQAGKGDACAGCPNQNICASAPKGPDPDIPIIQERLSSVRHKILVLSGKGGVGKSTFSSLLAHAFSANPDSMVGLMDTDITGPSIPKLMGVESETIHVSNAGWSPVWVTDNLGAMSVQFMLPNRDDAVIWRGPKKNGLIKQFLKDVDWGELDYLIIDTPPGTSDEHLSVNSLLKDSGVDGAVVVTTPQEVSLLDVRKEIDFCRKAGIRVLGLVENMSGFVCKNCNTESQIFRATTGGGKRLAKKMGIPFLGAVPLDPRIGMACDYGESFVDGFPDSPAAKAIKQVVRAVGQLVGEDPDSVLPDDLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMN6</accession>
    <name>A0A5N6TMN6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_142573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMN6"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="310"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="750" mass="84657" checksum="DDF02E17DF20F8D7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMP4</accession>
    <name>A0A5N6TMP4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3' exoribonuclease family, domain 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_30169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMP4"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000019">
        <property type="entry name" value="3 exoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="41"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="33972" checksum="BFC9483AC7AFDC57" modified="2020-04-22" version="1">MADRRRINGPPGGTRPAVFASSLNTADTATGRPQRQRQFNELRKIFLKTGLIPSASGSAYLEYEPSASLAAARSSPKSLIPPSSALKLACTVHGPKPLPRSATFSPNLVLTTHVKYAPFAARKRKGHIRDSSERDLGVHLETALRGVIVAERWPKSGLDITITILEAEDDRWWGDAPDSHDAPWGMINVLAGCITAASAAIADARIDCLDLVAGGVAAIVSDESEDSEAKPKLMLDTDPAEHKAILSACVVAYLPSRDEITEIWLKGDCSRAMLGADDKRSGHDALIDGAVDAARGAHSVLAEAVRESAQRFVGLAAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMR0</accession>
    <name>A0A5N6TMR0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMR0"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="868"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="919" mass="101774" checksum="E64A3AD096FBBE3C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMV5</accession>
    <name>A0A5N6TMV5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMV5"/>
    <dbReference type="OrthoDB" id="4343623at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="141" mass="15373" checksum="6FCFD5E97E475560" modified="2020-04-22" version="1">MWSSLVGRSMISSRFRDLMSSVRLGYISGQLFLGLDFSFWNLSYLRVYFTLIVLIWLNWLVCGNCFIMDPSDDTVAKPRNDSVASENSLASNLGAVAGSSLDEVKNTISSVAANESVQGVWSQVRYLAGGRSGGESQGLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN83</accession>
    <name>A0A5N6TN83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 15">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_159457</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 15"/>
    <dbReference type="EMBL" id="ML742188">
        <property type="protein sequence ID" value="KAE8147833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN83"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8147833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="41740" checksum="EDBE4E4EAB01E2C9" modified="2020-04-22" version="1">MAEFVRAQIFGTTFEITSRYTELQPVGMGAFGLVCSAKDQLTAQPVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAACIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVKSLPKRERQPLANKFKNADPDAIDLLENMLVFDPKKRVRAGAALAHEYLAPYHDPTDEPEAEEKFDWSFNDADLPVDTWKIMMYSEILDFHNIDQGTDAGQVLVEGAADNQQNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNA8</accession>
    <name>A0A5N6TNA8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_26201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNA8"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="843"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1219" mass="138589" checksum="4C655207554396D7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNC3</accession>
    <name>A0A5N6TNC3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742186">
        <property type="protein sequence ID" value="KAE8147873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNC3"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6869" checksum="24B9AA59639E5E2E" modified="2020-04-22" version="1" fragment="single">MATPQFWSTPLRYLRWASHEKPAIFYSLVIGAMGPVSLVTLPPIRRAFGDVDPEPIPLTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNJ0</accession>
    <name>A0A5N6TNJ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_25579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNJ0"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="777" mass="85672" checksum="3283D418F40AC394" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNL3</accession>
    <name>A0A5N6TNL3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_142517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNL3"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="10"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="224" mass="24837" checksum="BB3A7D058A57B2DE" modified="2020-04-22" version="1">MSRTTAVPRITLYLDIVSPFGYIAFHVLRKSPVFAKCNITYVPIFLGGLMHACGNTPPVNIKNKDQWIMKERLRWARRFSVPMVEQVPEGFPPVTLATQRALSAISLKSPGKLIPTIEALYDSFWAQGNIKIGQLEGFSPVLEKVFGNSGAQEILKAMNQPSAKDLLKANTDRAFKSGAFGIPWFDCTNTKGETEGFWGIDHLGQVAEFLGLDRDSDQGFKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNN2</accession>
    <name>A0A5N6TNN2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1771-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_142486</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="LaButti K."/>
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                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
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        </location>
    </feature>
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            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="70" mass="7555" checksum="210122A609BE6FCC" modified="2020-04-22" version="1">MSRNHIPALVAIGVGIFTGYYTFQPSLKELQVDKTTPQREQQQPQDAQSTMTSVKGGSETGVKSDAGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPA0</accession>
    <name>A0A5N6TPA0_ASPAV</name>
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            <fullName evidence="6">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BDV25DRAFT_21284</name>
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    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742171">
        <property type="protein sequence ID" value="KAE8148182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="GOC"/>
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        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
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    </dbReference>
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        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23022">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="43"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="280"/>
            <end position="434"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="683"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="949" mass="105944" checksum="FB8426CE80871966" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPB1</accession>
    <name>A0A5N6TPB1_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Conidiation-specific protein (Con-10)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="87" mass="9139" checksum="3DA4B66B5D87C197" modified="2020-04-22" version="1">MASNSNPGNFSNRSQDEVSNIARKGGQSSHQGGFASMDPGKQRDIASKGGQASGGSFEPGSQRAREAGQKGGSRTSYDIQDYDQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQC9</accession>
    <name>A0A5N6TQC9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_158037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQC9"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="12006" checksum="9A00F4D3C7CAA79B" modified="2020-04-22" version="1">MAQERSGIVVGLNKGHKTTPLDTPKNRISRTKGQSSRRTAFVRDIAREVVGLAPYERRIIELLRNTQDKRARKLAKKRLGTFGRGKRKVEDMQRVIAESRRVTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQJ6</accession>
    <name>A0A5N6TQJ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_141595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742152">
        <property type="protein sequence ID" value="KAE8148636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQJ6"/>
    <dbReference type="OrthoDB" id="4500984at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="263" mass="29348" checksum="9E013D875361E4EF" modified="2020-04-22" version="1">MESFTGQNAHLRSRPSVELGYDERVTGVQWGPTVQYPQTFPSHILDANGQLEPSISVARSLEPLSLSPSLSISPPTVTACLKPSSTSPVGTAHNLQVPYNESRRQTQNRAAQRRFRERREQERLQARAQLEELRTENDRLTEQFELNRDKGKRLEEENERLKSELHVLRKRWQAALRLMSDMVQQDDRAAGLLSPTTDPSSSSASSPSSSISPSASACALQRDMQSLRSSVMMQTLVSLFDERETGLAYSRGVSESLSSDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQY1</accession>
    <name>A0A5N6TQY1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_157630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742147">
        <property type="protein sequence ID" value="KAE8148766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQY1"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000172">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="247" mass="27498" checksum="088A1CB61D27CF48" modified="2020-04-22" version="1">MASQGFGSRSFAASTKLPDRSVNANPTPFGASTFSRQRLGAPGPDLADAGRSTQQAPQPPVHSQTHGPSQDSNPLSRLTEEQREEINEAFTLFDLDRDQHLDYHELRVAFRALGFTLPKQELISLLTTYGVPRPQVQQQQQQQQQSKAAPATNPQHPSNLLMPLSAFQAVTALKILERDPRDEILRAFELFDEGGKGYIDLEDLRRVARELGETGLEEEELRAMIEEFDLEGVGGVTREAFVSICWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRI4</accession>
    <name>A0A5N6TRI4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_141374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742143">
        <property type="protein sequence ID" value="KAE8148887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRI4"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024811726" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="507" mass="54461" checksum="5AD49B37C4CF9A2C" modified="2020-04-22" version="1">MVSMKSLSIWASSLLYATLLRGCSASDSHLGDEHDIGPGLGSKLSNGASIYFPGNAEFSNATARWSGYGAPNISVVVEVANQWDVAETVKYANRHHVPFIAINGGHGNIGTLENVHHGIEIWLHKLNAVAISDVGNTATFGGGVLSVDVINALWAANKQTVTGVCDCTGFLGPALGGGHGYLQGQYGLISDNFVSLEVVTADGELRIVTPTGPNSDLFWAMQGAGHNFGIVTSVTMKIYDVPGDGTWAFESFTFTQDKLEALFEYLNTVGDDGNQAVDLAYWVTFAREEDVDPANPIITIFVVQSNAATIDAEVSESLHDLGPVVSEAHAGPYTSVSSWTEFNLGSRACGKGGPSMIRFPINLKQYDIPTQRAAFNALAKGTLEHPGLQHSTIMLEGYSVQAVKAVDEVSSAYAHRADHLLVSPVIIYMNETDRAPALEFGDQLRSIFHAGSGESELHAYVNYAAGTEALETMYGYEPWRQSKLSALKKKYDPTNRFGFYAPIPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRV2</accession>
    <name>A0A5N6TRV2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_130646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742135">
        <property type="protein sequence ID" value="KAE8149083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRV2"/>
    <dbReference type="OrthoDB" id="5340163at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF584">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="900" mass="103108" checksum="D3A2B7A070FBEAD6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS76</accession>
    <name>A0A5N6TS76_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS76"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="313" mass="35015" checksum="8173601D0113881E" modified="2020-04-22" version="1">MTTKTTTTTNKTYTYTYSPGSESKPTLLFLHGFPSTRQTWHFQITHFMEQGYGIIAPDLLGFGDSSKPRDLDAYRLKPMTADIVSILDQEGVGKVHAIGHDIGCSVLSRLVDYHPDRVLSASFLVVPYTPPGMEFNLEKVNELCRGVLGREKFGYISFLAAEGSEGVVERFSESLLSLFYPHDPDLWINHLGPTGSIEKWLLSDTRAPLAPYISKQEFQALNAQFTGSSLNWYKALVRNINIPDEITSQPPLKGKIDVPVLMICPEEMDFPVDGIRDVAADVMVRTCSTRGHWVQLERADEVNGFLGEFFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSB8</accession>
    <name>A0A5N6TSB8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_167934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSB8"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="49860" checksum="3924BA41F27E78C1" modified="2020-04-22" version="1">MAINGTNGTKATNGTSAYHAASTQEAIQAEKDFAAHNYHPLPVVFARAQGTSVWDPEGRHYLDFLSAYSAVNQGHCHPKLVAALVDQASRVTLSSRAFYNDVFPRFAQFVTQYFGFDMVLPMNTGAEAVETGIKIARKWGYKVKGIPENQAVILSAENNFHGRTFAAISLSSDPESRENYGPYLPNIGCDIPGTDKPIAYNDKAALREAFEKAGPNLAAFLVEPIQGEAGIVVPDEDYLQEARALCDKYNVLLICDEIQTGIARTGKLLCHEWSGIKPDLVLLGKAISGGMYPVSCVLGRKDVMLTIEPGTHGSTYGGNPLGCAVAIRALEVVQEEQMVERAEKLGHVFRDGLMAIKSPLIQTVRGKGLLNAIIIDESKTNGHSAWDLCMLMKEKGLLAKPTHQNIIRLAPPLVITEDEIKQSLEIIAQAVTELPTLKGAAEDKVIPPPEKKVKVSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT84</accession>
    <name>A0A5N6TT84_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_124553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742118">
        <property type="protein sequence ID" value="KAE8149585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT84"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="125" mass="14557" checksum="AC9363097B06D44C" modified="2020-04-22" version="1">MFEGIEDRPGRSTQTTHSGFLGLSLRVFVDRHELRTFLSHLVHLMKGMACFDRSAIRREGSIMALHTRYLVFFSWFWFTFLSFSLFIFFSFLDLLLSFFFSSICFFISSSSLRSSATGIIGESRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTC9</accession>
    <name>A0A5N6TTC9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTC9"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20852" checksum="DBB202CEF691DA44" modified="2020-04-22" version="1">MRTYNPFGFTLDFEPSNVHFIQKLKTSDVSEIFHISYEEHPYFLKVFHMGDDPGFSPDGRDLCRYRCESQAYFSLSRHGACDQGIVPQFYGVLENLDPSIFEPDLEAFKGDKNQPCGILLEYLQDASTFTSDERSEELFLYSTEALKQIHQARVIHNDPHPTRNLLVASGHRGNGEDRLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU02</accession>
    <name>A0A5N6TU02_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoglobin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_120887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU02"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="38"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="376" mass="42182" checksum="2A1E5E3654454C55" modified="2020-04-22" version="1">MSMNQFDDTNSINMDPVSPVKSDIRRATRKELYTDFGKRMEYLHAFLDFTDEDIEIFNKGSKFLKPAIPSLTDRLYGKMLDFELTARALRTRNTASEAPVKDYFKKDSPHVQRRKIFWKWYLTRFCSDPGKLEYWQYLEKVGRMHQGQELMHPLMIEYIHMNACLGYVKDALIDTISTHPELSVKFKFALIRSVCKVLCIQNDLISKCYIREGQEFFEDEPSTGDTSPTSNTSPRNTTMSTSTTSSASNFSTTDSVSTADNASATDNTSISESSVKTQEKEKENLPRCLVPGWNNSRPNSAGGTQTPRDRSGSVDVDRVLTSTTSASSDCPSTASSHRAMQSIASTSPHLISPFAAGQAFETKIWSSGPKKGNKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU96</accession>
    <name>A0A5N6TU96_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU96"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="570" mass="62226" checksum="18BE89393E2486CD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV33</accession>
    <name>A0A5N6TV33_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transferase family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_140061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV33"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025019651" description="Transferase family-domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56880" checksum="A73836D589BA1903" modified="2020-04-22" version="1">MVELLGAVWWLLGVIRWLLELGRSKEGDEYDTYPLHFMDQMAAIRGLITSYMFRYDCVLDAEELHDSLTRLLQLRDWKKFSGRLRGSNNGRLVIRVYRDMKRQSLCRFSHVSYGVSVHEHSLGRRLPRQTGPTPSIQDGFDTFREFSVPPDMPGDVKHYLTTDEPLLSLRIVSFTDATLVSITFPHVVMDAMGVADFLGAWSAMLQQRVDQVPPLLGVKEDVMASVGSRGDAKAQSSHILERWQLRGLALVAFILQITWDRFTERGIQEGTIYLPVEFVAELRQSAHSEHRREHGMDPPFLSDGDLIAAWGAQMILSSRANKEKSAMICNMFNIRSRVKDVLRSPGVYLQNLVLPTTVNMNIQPTQGHPGISVGIIACLIRDAISEQVTDGQIHRLMRIMRAAHARTGLMPFFGMADSTIITCTNWSKARLQEAAYFAPAVRSSSESGGACVASAGTVLNTSGALRDMLIIYGKDAIGNYWVHGHLRRETWTLIQNVFDDRSSRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVB6</accession>
    <name>A0A5N6TVB6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain binding protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVB6"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="279" mass="31991" checksum="D7B2F647535CBB42" modified="2020-04-22" version="1">MPKERNFNPAQAQRKLDKQKSLKKAKAEAQARRNEKLARRNPERIERQINDLKALEETGQKLRPREQELLEALQRDLRTVQKAREALGDKAPKFESFQSRRGGFGGRGRGDGVLGKRRRDEHGHFGQDSESSETDEEVRRIPMPRDTPPPIPRQYQKKRDGEADTGPRGHHGLPTKPPVVESRTVYEAQPEIKDLRQEAVKKFIPAAVRVKQDAIRGQGKLLEPEEMDKLEQAGYNAGPAGREDQGDDDDTQQRLLEEEQRFNQELRSVQIEEVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVK7</accession>
    <name>A0A5N6TVK7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_154525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVK7"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="599" mass="65536" checksum="3BDC3E49158B1385" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVU2</accession>
    <name>A0A5N6TVU2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVU2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="231" mass="24791" checksum="D63418012FE07E06" modified="2020-04-22" version="1">MNIHTAEKEAFGVSILHSTRVDITLRTTTVAGPAEGGGSRNVMVCSPVEAKFIGLPFVAKAMTTSATRNLASRLTCIIVEIGIVVIPDPFSAPNFIYTFIGGVVVQPDAKCAPHSLRNGGSESDERQRQTHFIPGCLCLELSNSTTIQTVAAVLYRKILFAITLEGYGYAMRLPAKELSTSLLYLGDICGENAYFFGLAHIIIHTSLIAQGVDPQNVDTGTRTGKLSGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWH2</accession>
    <name>A0A5N6TWH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Telomere stability and silencing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_154360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWH2"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="12">
        <location>
            <begin position="96"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="156"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="307" mass="33572" checksum="5DE4685BA43C2D6C" modified="2020-04-22" version="1">MATQNVNVLLSTFPGLSLPSTLSFAISSTSSLSDLTEKITSYLPSRVPLQSLILTTTNGKQILPSSDRLPSLLTTSDGESITTNILPLRLSVALCGGKGGFGSQLRAAGGRMSSKRKRNQGDDNGSSRNLDGRRIRTVNEAKALAEYLAVKPEMDKKEKEERRRRWQAVVEAAEKREEELKNGGHKQKVDGQWMEDKEEMNEKAREAVLAAMKDGMWTDNLHNAIRDNILGGSSTSASEGSGHDSTSSSEEESDDEQEMKDAPGPSEKSGAPRRYIGFDDDDEFMSDSEEEEDEQDNDPKGKGKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWP2</accession>
    <name>A0A5N6TWP2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_154325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWP2"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39633" checksum="0605BF5136FA610A" modified="2020-04-22" version="1">MWDLRISWIPSFIQLFIFGREITHPTNTMNDITPGQLSTTAIPSYVLEYAPLVWLHSEETYWPSDIREQLVHTTPKVDWKLIEGAPSPVTLNNLNELNQLGNTSVYLTSQESIDADPQPTWFEGVKPDENGKTGSTVTSCIVTYDHGDGILDAFYFYFYAYNQGNTVLTMEFGNHIGDWEHNMIRFSKGVPDAIWYSQHATGQAFTYAATEKRDKRPIAYSAKGTHANYAITGKHDHTIPHFNLPDGLIVDVTDRGTLWDPIQNAYAYSYEKVEGKFHPYDSSYPVNWLYFDGQWGDDALPGGPELFGQKKYAAGPNGPKFKHLVREKVCPDSPCVVLPFRIWVAPPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWU2</accession>
    <name>A0A5N6TWU2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_139448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWU2"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="155"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="305" mass="35918" checksum="2F5A8BB3C6A658BF" modified="2020-04-22" version="1">MDVVMDVLDTFVFDHFYAWILPERNSVPSQKTYNQHVNLYIPLHPSSYVDASIWKRDDLARQATSLFLVSWIFALAMYLIGSTIIYHTLFDKRLMRHPHFLPNQIRQEIRQGLGAIPVIAVLTTPFFLAEIRGWSKLYDFASEAPFRGYTWLQYALFVCFTDCGIYWIHRGLHYPPVYRWLHKPHHKWIVPSPFASYAFHPIDGWSQSLPYHIFPFLFPLQKSAYLGLFMFVTLWTVLIHDAEYLSQSVIVNGAACHTMHHLYFNYNYGQFMTFWDRLNGTYRTPKEDGFLQNENRKAQGGVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWX3</accession>
    <name>A0A5N6TWX3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_153619</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWX3"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8150885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="641" mass="70851" checksum="6FF65ACFFAD59BD8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXN6</accession>
    <name>A0A5N6TXN6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_128989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXN6"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="277" mass="31603" checksum="17F1F1EBED964395" modified="2020-04-22" version="1">MMVLVSRSYKFWNYTPSIAAAVIFILLFLTLTVLHSWKLFKTRTWFCIAFTIGGFFQIIGYIGRAVAHDNTTTMGPYIVSNIFILLSPTLFAASIYMTLGRIIRCVKGEHLSVIKVSRLTKTFVWGDVLSFVVQGNSSALSVLGYDTWSKVAVVGGLAIQLISFSIFWLTAIVFKNRIRRSPTPESVQTGIPWQKSLYMLYTVSALIMIRSIFRVVEYVLGNDGYPLRHEWTLYIFDSVPMVIVMVVFFVWYPNKLQRNADFEGGIPLTRSYSNLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXR7</accession>
    <name>A0A5N6TXR7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXR7"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="364" mass="40128" checksum="BFD5B35BEA0B417B" modified="2020-04-22" version="1">MHPHLHDPPRLVLKGSSQEIGRQHGSQLQEQIKSQLRLYGELFEHTLSMKWGDVLQLAEEFRQSLERSTPRLYAEMQGIAEGAGVGILDIVALNCRSELSLGGFSDGCTCLSWKKSDDARVLAQNWDWTSAVQKNLALLDIEQPGRPRIYMITEAGMIGKIGFNSAGVGTCLNVIKARPCVSSKLPIHIALRLCLESTSVDGALETLASHGGVASSQHILLADSTVSLGLELSPLGDAHLKEDEYGTVAHTNHFLENKNVDTPPWNESSPFRLERIRKLTRELSDSGVQGELITPGLLREKVFSDTYNAPGSICAQEDPGNHWTRRSSTLFNIVMNLYRQDPWAEIVIGKPGSGESTVLRMPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXS8</accession>
    <name>A0A5N6TXS8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXS8"/>
    <dbReference type="OrthoDB" id="5372734at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="39313" checksum="7E348E482E6BC62D" modified="2020-04-22" version="1">MSDDEDYYDEYDEDIFWIEEPDPGVADDLAATANYDAIFFEDPSFEVEEYFSDWDDQSDDYYDEDPTAVRRQRAMGLWPNKPNHLRKADGVKTKTMPTPEKLRTKKSTLTTDIASFQGTVWKTPNDDTPPRQLHEPGDGEKVALLKNWREIFRSSHPALGRTRVRKVAPPYTNDMEPPRSRVGDGKMMDISSDENSGVSSLERLRETDVGSEDVSKTTSPAKSSASPPLTVHARRVVASPSDLPVNSKMLEHEYPIEGHDTAVQSSDPITSVPQPQEPRLDRHNSKSAPAPPVRSRKRKASDSVDDQESNGNSETTTTKPKSKRIASKKVGESVDPPTSSGPVRRSARNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY04</accession>
    <name>A0A5N6TY04_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY04"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="507" mass="57199" checksum="F8CCE5901985B8E6" modified="2020-04-22" version="1">MTDEDYERYLRSLLSRPGPRTPTAAEDNLEATRHIVDEACVNFFIYKAGQSLELNDGSFLRICTVFRDASNAVSFGGRRLMRTWNHKGTYVPKARNELIWIVPEKRIIPFDDVKRFVTINFTNSINPDGQHRLGQLFCRLKESRKGETLNEEGSVEYVPYAEADADFRVEPAILRRLWRGQTCAFGEAESKTPVIVLDDEPGTGDKTRRKYTFGDGFCGAGGVSCGAQLAGLQLKWAFDNSEHAIDTYRLNFDTDCEYSDVFSFLTNDYQFLKVDISHGSPPCQTFSPAHTVNSVHDDANSACIFSCSDLLKKARPRIHTMEETSGLFERHKETFYRVIQDFVEIGYSVRWNVLRTDDYGVPQIRRRLVIIASGPGETLPPFPGPTETCTIHRAISQIPQGTPDHDVNTAVVKARERGFIRPPYDAESLAHTITCSGGEGNYHPSGERKFTHRELACLQTFPLSFRFGGKEVTKQIGNAVPPKLATAIFREIVRSLRDTDERESNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYY4</accession>
    <name>A0A5N6TYY4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_128669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYY4"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF20">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 1 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="249" mass="28626" checksum="15C5D2D1F2A9B27B" modified="2020-04-22" version="1">MSKPITVWLTPSGPNPWKVVVILNELEVPYVIESFPFAEVKKPPFIDINPNGRVPAIVDPNTNITLWESGAIIQYLEEVYDTDHKLTYDSFAERHLLNQFLHFQMSGQGPYYGQAGWFNVFHPEKIPSVIERYQNEVHRVLGVLNTVLDGKTWLVGDKCTFADLAYLPWNSRLNMVLQTAVGVDPLDAYPNVQAWQRRMESRDSWKKSKETMVKLMNDQGLQENGMPLGVNNIKEYEEWLARQTSQAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ07</accession>
    <name>A0A5N6TZ07_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_90543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ07"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="552" mass="62383" checksum="F622F44195BED92C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZD1</accession>
    <name>A0A5N6TZD1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZD1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="178" mass="19759" checksum="4A26C748994389CE" modified="2020-04-22" version="1">MPEVPKASEPPSYEHGILIMPSGCALESFGRLKRGNWYLRVGRTSTRAGICNGVLTTCNWVGSDRYRFDENGNQVDLGDWTTKEHLILDRTTQGEKDIQCEFGWPGDSGSLVIDQHGKVCGLYYGNATSWISPESVTIKHASAGLAMDMTEVRKGIRLRTRELVEGRKTPGSIVRLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZF5</accession>
    <name>A0A5N6TZF5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">BDV25DRAFT_88028</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZF5"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="277"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="451"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="469"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="486"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="552"/>
        </location>
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</entry>
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                <person name="Nybo J.L."/>
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                <person name="Daum C."/>
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            <strain evidence="1 2">IBT 18842</strain>
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                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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        </location>
    </feature>
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            <begin position="23"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="198" mass="21547" checksum="44926A130C84B93B" modified="2020-04-22" version="1">MRTTFLLPAISQLQLFSTDALAQPQDPRALALDNQSMQYTLRTFDMRNSNIAQSPPETIDCCPLGSKHSNGQCVPDDGRHCQMCRPGYLVDLEGNCILDPFMRSPADVPDLCLPGYVPDEGGCTLVRSTVSEDDEDGGCTLGPEYNLSGVPDDECLCLPGYILGDGSTLDKESNAPDYTNCSPGYFFDGRECVEMSPK</sequence>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chovatia M."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">IBT 18842</strain>
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            <location evidence="1">Nucleolus</location>
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        <text evidence="2">Belongs to the CWC22 family.</text>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U176"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8151981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="330" mass="34863" checksum="B822572ADA40F59B" modified="2020-04-22" version="1">MGFGAPRGRGGPPGRGGRGAPRGGGGRGGRGLFNHQFLTGQQAGTLLRGFGAPRGRGGPRGGGRGGPPGRGGRGGPRGGGRGGAKGARGGAKVIIEPHRHAGIFVARGGKEDLLVTKNLTPGEAVYGEKRIAVESPVEDGTVTKTEYRVWNPFRSKLAAGVLGGLDEIYMKPGSKVLYLGSASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLVPMVDVIFADVAQPDQARIVGLNAHMFLKEEGGVIVSIKANCIDSTAKPEVVFAREVQKMREERIKPKEQLTLEPFERDHCIVSGMYKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1K4</accession>
    <name>A0A5N6U1K4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 13">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_150968</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1K4"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000189">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="116"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8152494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="53816" checksum="5F46F96291E3EB6E" modified="2020-04-22" version="1">MPSPFLNPGPQSKLDSLALLQLRRDLTIPTILQLQDDQDQGYKEGKVTNTRFGSFPHSTLHDQPWGSQIIASKVDTGSRGRIQSKGKRKADELYSSTAAEDANKSSPQVPVAASSGFLHILYPTPELWTASLPHRTQVVYTPDYSYILHRLRARPGCTVIEAGAGSGSFTHASVRAVFNGYPTAESPAKKKKMGKVCSFEFHEQRAGKIRDEVKQHGLEDLVEVTHRDVYEDGFLLGDPKTGKSPKANAIFLDLPAPWLALKHLVRNPPSGAESPLDPSSPVYICTFSPCLEQVQRTISTLRQLSWLQISMVEVNHRRIEVKRERVGLDYEGARGTVVFPKSVEEAVERTRTVEARSQRFREIQNQDDDETTPAPKAANETPARQDPEVPVYEQGRLMHRSEIDLKNHTSYLVFAVLPRDWTEEDEQRCREKWPSNMVREPRGAPKGKRQMKREEKERRKQEGQPKEEEKQPNTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1U6</accession>
    <name>A0A5N6U1U6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_170388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1553" mass="170525" checksum="DDEB186574E6A6D0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U275</accession>
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        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="299"/>
        </location>
    </feature>
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        <location>
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            <end position="176"/>
        </location>
    </feature>
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            <end position="10"/>
        </location>
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            <end position="52"/>
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            <end position="75"/>
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            <begin position="76"/>
            <end position="86"/>
        </location>
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            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2I2</accession>
    <name>A0A5N6U2I2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_137560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2I2"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930277" description="superoxide dismutase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="9">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="191" mass="20558" checksum="CEA3829F30364A58" modified="2020-04-22" version="1">MYLHRIIAATLATSVIAQTQDAPEVTSSPSDHVYEAILPENPFFDKGSLDGNIRGTVKAQSAADGKGVSFSVSFRNLPNEGGPFLYHIHDAAVPSDGNCTATLDHFDPFNRGESPPCDANEPHTCQLGDLSGKHGKITQEPFTKEYIDPFVSLATDSVQFFGTKSIVLHFGNKTRITCANFVKAGVEETGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Q4</accession>
    <name>A0A5N6U2Q4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reductase with broad range of substrate specificity</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Q4"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31358" checksum="5EB336CDF463DA97" modified="2020-04-22" version="1">MASNPVQNGLFVHNNTTAPEHPSLLSMFSLKGKTAIVTGAGAGIGLSVAKGLAEAGANVALWWNTNDKCPERAAEIASTYGVQTKAYQVNVTDAKAVQEAVDQTVKDFNGRLDVFIANAGIPWTKGPMVDGPLEHYTDVVSIDLDGTFYCAKAAAAHWRRQKEEGTDLNGNKLTNFTYGSFVATASMSGHIVNFPQMQAAYNAAKSAVIHLCKSLAVEWVKFARANTVSPGYIATEISNFVPQETKNIWRDKIPMGREGQPEELKGAYLYLASDAATYTTGADLVVDGGYCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2T7</accession>
    <name>A0A5N6U2T7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2T7"/>
    <dbReference type="OrthoDB" id="4646997at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="389" mass="43531" checksum="BB7AAD2C3E9145FE" modified="2020-04-22" version="1">MAPYFSTVVSESAFKARFQAENAKPFSELENAAASCWGRPHLLACRVIRREPQRTLLPILSDYISPSDTQCPSNEIRAYLQGPDLALMGQSEHYLVRSSDCPFSVAQIWAAMAMFKGDQERRTRLPLVPKQQDYNDESDVETRDPKRRRRYTFQPGFVDSSGIQIGSSSPLADGSFDGSEVSSLAYVDPDSHYLSMTPEDNTLRLASCVIRHILYFAPPQDAPIQPVAVEFRDAKTRLSASTWVRERPIIAIDDGGLCLRRQNPDGGFMLSNDHVAILEGKTQFHCLEDGRPVISDDSFAQMICEALATRLSDATGHSEQSVIIINATQHYMCFLQVDISDDYLSDFESPTPTHMLYVNATPWFDLSQRSGRESVLANICGIMRRAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3W6</accession>
    <name>A0A5N6U3W6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3W6"/>
    <dbReference type="OrthoDB" id="4186099at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024951050" evidence="1">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="112" mass="11796" checksum="D0AA0B9AFBEF4E42" modified="2020-04-22" version="1">MRSTALITASMALAGFASAQCAAGATADCKKGFNYCAKTLRDRGEADSAINVALKAADHGGMVGLPGLQNAIIFHCNDDYTLTVVKSCESGSFCVDGGWEKDDHCGDKWRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U461</accession>
    <name>A0A5N6U461_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U461"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="249" mass="27027" checksum="B2958B7FB6F4C35D" modified="2020-04-22" version="1">MTKPTLIFAPGAWYPSTAFTPLTTTHLTPHNYQTTTITFPSIQDAKTITSLAPDIAAVRNAVSPAVEAGQDVIIISHSWSGLPVNSALEGLSRAERQEQGLEGGVVRLIFISAFLPTVGQSLIGAVGGVVPDWYVFDDEHETITADDPYKLFFHDVPDGREWTETLRPHAAATKNSPAVAAAYVDIPAVYLLCEEDRAIPIAVQEAMVEKAREMGANISTERVKTGHTPWLVDGEFVAGFIRRWAGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4A7</accession>
    <name>A0A5N6U4A7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_27857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4A7"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="100001" checksum="A3D5CE27CB11EF9E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4L9</accession>
    <name>A0A5N6U4L9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4L9"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="494" mass="54565" checksum="EB7B0EF920577A9A" modified="2020-04-22" version="1">MPRQHVAAVECQIENDDAATRYNMRVANEIIEQIGFGRYQWHMFITCGFGFLVDQMLPVALGLVLPQITKQWEIKYPEMMTVSVFAGLLVGSVFCGPLVDMFGRRSVWMVSLFGVTLFTMVMAASPNHIVFAIICALQHMFTGGNLAIDLTVYVENLPKSKDFILTAVASWWALGSALGGLIAWPLIEHFSCPIGTTPTQCKSSDNMGWRYQYIVIGGLSLIMALVRTLVLPMEESPKWLIAQGRFQEAVVAFRKIAGMNKREIDISVEMFQSLHPPLMTSSKMQRTMAHIRALFVPKRLALSTTSVIVLWMCMGVAYPTYTVFLPVYLANNGAHLGSGSTFQTYRDYTISSTVGIFGPLVSAFLVNIRLLGRRRSMAITAIFTAAFAGGFTSVRTEGANIAFSSMVNFGQHAFYSILYSYTPEVMPTAHRGTGCGLAMACGRTASLACPFIATFTDLKTSIPIWVCVGLYAVMACLSLLLPYEPKEFSSADRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4U2</accession>
    <name>A0A5N6U4U2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="320" mass="34478" checksum="417D1860E86735AB" modified="2020-04-22" version="1">MSLTYDPDFAAAAAPMLAAIASAPQPTVHNIDELRAMLDSWLGGLPDLSEVPDIEETIYHTPSYDGHLVAIHHYAPKRESAAPAGPAVLHAHGGGFISGSAAMFRIPMQGMVKASGVPIFSVDYRLAPESPFPAAAEDMYAALTWLHEHAEEVGVDRTRIATMGESVGATLATSAALMARDRNLSPPLAKQLLIYPCLDDRTTLSDPALEPLLLWKQEHNLTAWTAYLGQGKVGSDHVSPYAAPARATRFDGSPETYIDVGEFDLFKDESVRYAGLLEKAGTKVTLEVYPGVPHSFELFAFASQATQRAMGLRVAAMRSF</sequence>
</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
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        </location>
    </feature>
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            <dbReference type="EMBL" id="KAE8153818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="227" mass="24211" checksum="8F9AE892715A0B16" modified="2020-04-22" version="1">MERVTVEEDPRSAPHVALNPEGHSYPYIYVPDERDKYLNPSATVHYAAVSPQYPVYPAPAPRRKKWIWITAGAVILVIIIVAAVVGGVVGSRSAHQDSAKSDITPTPTPSSAGANATTSTTSLFSSTSTPTNTSTSASAQPTDTTFGATVHMSRNDTCGGTTDSFSVLNSNTYRCVIVPAEKRSIRVSQNQGCKVKTWSGNNCLGLNFRVPDTECHSVLYASVSVDC</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="592" mass="63946" checksum="39704FAEBC604BBC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
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    <comment type="similarity">
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        <property type="protein sequence ID" value="KAE8153941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="119"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
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            <begin position="152"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8153941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="199" mass="22071" checksum="7A18297825012C3B" modified="2020-04-22" version="1">MADDTQTQTTPTLEQQDSPQDPSQQKKPKHEFPKSQVGKLWDAFGNPEDSANVLAASGAASSRKKNDDITVTDAMKSLSLKEASSFYKAPCARDSLLLGIGAGFGIGGIRGVVGGLRSMWTACNWAVGAFALTSLAAHEFCQRRRVQELDGMKQAVELMKELKVKKQREKEQKVEEAARLAEEEKKRKSWTNMSNYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7P0</accession>
    <name>A0A5N6U7P0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_103362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7P0"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="270" mass="30547" checksum="75E42B8FE44A8C2C" modified="2020-04-22" version="1">MPYFTYETDGTGLARFLPDPLVAQYVFCVFIALAWCNAIELVVLCLNTFKRYAGTYFWSLFIASISVIPFGLGYLLKMFHISFTDSFFELAITDIGWAGMVTGQSLVLWSRLHLVLQNRKVLKALLYLIIFDGILLHASATTLEFLNNAYPADHNVGMAFGIMERIQVVWFCAQELLISFVYIAETSRLLHLDRGGNSRTILTQLIIVNALIMVLDVSVVAIQFAGYFTLQVTTKVLVYSIKLKLEYIILGRLVDVAHIRSQPETPRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7U3</accession>
    <name>A0A5N6U7U3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dyp-type peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_135591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7U3"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048327">
        <property type="entry name" value="Dyp_perox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="8">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34820" checksum="2C72530F926240EC" modified="2020-04-22" version="1">MSRRVPIESQRVDAPLTQSATFLTLTVKDNPDAIQTVRSTISGIDDLAKNVSIRDLGSQFACTVGIGSDIWDRLTRLPRPAELHPFQEIKGAKHTAISTPGDLLFHIRSERRDICFEFERQLIDLLGDAVTLVDQTVGFRYFDVRDLLGFVDGTANPVGPSVHNAVLVAEEDASFIGGSYIVVQKYVHDLSQWKNLPVEKQEAIIGRTKWENIELDDADSGQQSHKSLATIEENGEEHEILRDNMPFGSPSSGEFGTYFIGYTRRLWVVEKMLERMFVGDPPGLHDLLLDFSSPLTGVTFFAPSASVLASLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U825</accession>
    <name>A0A5N6U825_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_171531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U825"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:trehalose-phosphatase activity"/>
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    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000208">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit, putative"/>
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    </dbReference>
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        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF75">
        <property type="entry name" value="SYNTHASE SUBUNIT OF TREHALOSE-6-PHOSPHATE SYNTHASE_PHOSPHATASE COMPLEX (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="460" mass="51370" checksum="E9E0067CDB7576C4" modified="2020-04-22" version="1">MASDNEKKRGLIIVSNRLPLSVNKEGDSYKSSLSSGGLVTALSGLTKTTNFRWFGWPGIGVKDDEDQKQVAAALAENSAVGIFLDPQLAHDHYNKFSNSILWPILHYQAGVAFDDDAWKAYQRVNEIFADTVAEQAADGDLIWVHDYHLLLLPAFLRERLKKQRKHCPIGFTLHTPFPAEDFWRALPVQKSLLEGILASDVVGFHTDEYKRNFTESCGRSLKSNIETEGKITLDGHESCVGTFIVGIDPQKFADSLQDPGVQKRIKELEEQYNGTDVIIGVDRLDYTKGLVQKLEGYNCFLNEHPELNGKVTLIQVAVPSRQDVKEYQDLEREISTLVGKINGEHATPDGTPLIYMHRSVSFTELTALYTVANACLLTSQRDGMNLVASEYVACQKDRHGVLVLSELAGAASFMTGGSITFNPSSAQELSESLYNAITMDKEERRERHESLREFITTHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U843</accession>
    <name>A0A5N6U843_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-utilizing chromatin assembly and remodelling N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_147383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U843"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="8">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="7">
        <location>
            <begin position="387"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="681"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1001" mass="115955" checksum="A3AC90383AA12E3E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8D5</accession>
    <name>A0A5N6U8D5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8D5"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="226" mass="25200" checksum="95342FE9F0D63276" modified="2020-04-22" version="1">MSVKFDHNIIVKFSDIAIQGKTQVPSPLETPSTYNNDTVVFGLFDGQLDIIVRLACLHAKALEDRAAACADSVQEFNAVNEWNPPNDEVPADAPFTSGEIACLYLLYKFAFLVWAACIAIHDAAGDEEKSALNHVNVQGLIAEALPLLDEELQEDLYPYLSIPLFVLGSACVDPEGQSKIKDVSSNILEGFKADIKEYAGPMFDMVNESWERHNENVEDSWDWRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8H9</accession>
    <name>A0A5N6U8H9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_170996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8H9"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024995916" description="FAD-binding domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="462" mass="50603" checksum="40CDA50896BCFDBA" modified="2020-04-22" version="1">MAPAPFKVIIVGGSIAGLTLAHCLEQAGIAYTVLEKHNIAPQLGASLSISPNGGRILDQLGLYDCIEPMAVAIKHVRFAFDDGFAFIERYPSTLRPRYGYPLLFLERQQLLGVLCDKLRDKSAVFAHKPVVSVRHTGEGVRVTTEDGSTYDGDIVVGADGVHSIVRSEMHNAASKLPSGPISKRKHDQMTSQFSCTFGISTDVKGATAGEVLWTSHDGHEVIAFPSHDGKVFWFLMVKLNTSHQHPNVPRYNHNNAIETCQAHVHLAVGNGLTFGDLWTRRWLFGMTALEEGVAQTWHFGRMVCIGDSIHKVTLEIGQGANLAIEDAAALANTIRELVKGNETPTPDELNSALKKFNDFRLPRVTSVCKFGSSVTRLTTGDHPVRALFARFALQYITKLCPVAGRRIFALADKIDYLPTPMRAGPEFAEALRPTRWLSPTLASAVVVSVLFFVFILAPSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8I2</accession>
    <name>A0A5N6U8I2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_147319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8I2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="92" mass="10549" checksum="6F88C754440BC978" modified="2020-04-22" version="1">MHYIDMRLLIQHDTSSFKTQVLMFEWQPSRNLYVYTANIPPGLLDKLDNPATSFHSCPVEIRCRKIPLKHSKSVINRLHNIFCPGSCACCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8K9</accession>
    <name>A0A5N6U8K9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin-1</fullName>
            <ecNumber evidence="4">3.4.23.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspergillopepsin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Aspergillopeptidase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_63712</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.</text>
            <dbReference type="EC" id="3.4.23.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.18" evidence="4"/>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8K9"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024988168" description="Aspergillopepsin-1" evidence="14">
        <location>
            <begin position="21"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="93"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8154942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="41980" checksum="0A10C6D183DCB490" modified="2020-04-22" version="1">MVVLNKLAAVAVGLSTAASALPTGPSTHSKRGFTISQITRQSARPGPKTASFPAIYAKAIGKYGGAVPAHVKSAVSGGTGTVVTTPEGDDIEYLTPVNVGGTTLNLDFDTGSADLWVFSEELPKSEQTGHDVYKPSGNASKLSGASWDISYGDGSGASGDVYKDTVTVGGVTAEGQAVEAASKISQQFTEDKNNDGLLGLAFSSINTVSPKPQTTFFDTVKSQLDAPLFAVTLKYHAAGSYDFGFIDKEKYTGELVYTDVDDSQGFWQFTADGYTVGKGEAKKSPITAIADTGTTLIMIDDEIVEAYYEQVPNAENSYSAGGYVFPCDSDLPDFTVQIGEYSAVVPGKHINYSPLQEGGSTCVGGIQSNSGLGLSILGDVFLKSQYVVFDSEGPKLGFAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Z5</accession>
    <name>A0A5N6U8Z5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_146562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8Z5"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="141"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8155095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="605" mass="66614" checksum="DEB4C203B5E83D37" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U925</accession>
    <name>A0A5N6U925_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_169297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U925"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8155123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="756" mass="84928" checksum="35FDD8C1BFEBBC2F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9J0</accession>
    <name>A0A5N6U9J0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_125989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9J0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="53"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="366"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="674"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="995"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8155284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1237" mass="134745" checksum="CCDC7A3DEF74C6C9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UAH1</accession>
    <name>A0A5N6UAH1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_38213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8155191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UAH1"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8155191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="56811" checksum="F7F9D4FC41877906" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCJ5</accession>
    <name>A0A5N6TCJ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_167655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="ML742931">
        <property type="protein sequence ID" value="KAE8144104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCJ5"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="53261" checksum="45632459E7B8E239" modified="2020-04-22" version="1">MSVLLETSLGDVVIDLLVDESPKACENFLKLCKVKYYNFSPVHSVQKNFTFQTGDPLGPDSPESDGGSSIWGLLEGPSKRTFSLDVPPKLKHDERGTVSLATVPSPQDPDQRIAASQFIVTLGENLDYLDGKAVIFGKVVEGFDVLENINGVFIDDRGRPLKDIRIRHTVILDDPFEDPPGLMAPAESPLPSKAQLATVRIADDEDLDDDMDEESMEKLRREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTQDEDLHLIFSRFGTILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSESWRNATISKRSSQRGGFGGVASLEKKRQYRASDNAREQEDDYAMLFDKGDPKRQPTHSRRSYSRSPRRSTNRERRVSRSPPRHSYRERGRYRDRSYSRSPVRGNLPRDKDRGRYYDGERRRDGRDSARYHDRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD61</accession>
    <name>A0A5N6TD61_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_100668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742587">
        <property type="protein sequence ID" value="KAE8144283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD61"/>
    <dbReference type="OrthoDB" id="3535998at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31879" checksum="9256BDAA0426276F" modified="2020-04-22" version="1">MASNPETQPKKRESRAGTRKVATLTTEQLERKRANDREAQRTIRLRTREHIDRLESQVAELMAKGDQYEHVLRRNAELENEIRYLKHQLALLSSGQGFSSAAPEGSYNAHPGSILPSSQFTEPLGVNPVSRAPSALSTSSQVSVQHDWPPYSTTGSPTIGESPDADYSNRVEPFLFENSLQAPNPMAVAAPQVSFNAPNGPPPEPPLHSYPHLHVGSGSHQSRREEHPLNPQHALQFASSHRSMSVPSIPLDREVRGYPILPGAQQYAQPPEQPPRNEYYEWPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD74</accession>
    <name>A0A5N6TD74_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_105153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742643">
        <property type="protein sequence ID" value="KAE8144227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD74"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="273" mass="30310" checksum="F74A542B7ADF0F4C" modified="2020-04-22" version="1">MSDEHIARQTASSLDRLENFNFLLSRHDPALAKSRHYSFDADSAGLAPFQNLSMEFDQTEGMGGLSVSSYDSIDDDRSPIDVRGYPYHAEKLNYSLPDQMISYPAHPIYPPISYGPDDLGHAPGALTPSDVSSSISPPNGQLGHTKYSTQIPGDHLASALSQEEHVRVAAEEDRRRRNTAASARFRMKKKQREQTLERTVRETTEKNASLEARVAQLEMENRWLKNLLTEKHEATSTRMPPPEDNAALNQKGSNGGTGQKHIQPKKKGVGTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDC8</accession>
    <name>A0A5N6TDC8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
            <ecNumber evidence="8">2.3.1.38</ecNumber>
            <ecNumber evidence="9">2.3.1.39</ecNumber>
            <ecNumber evidence="5">2.3.1.86</ecNumber>
            <ecNumber evidence="4">3.1.2.14</ecNumber>
            <ecNumber evidence="7">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">BDV25DRAFT_167020</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32 33">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 29">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EC" id="2.3.1.38" evidence="8"/>
    <dbReference type="EC" id="2.3.1.39" evidence="9"/>
    <dbReference type="EC" id="2.3.1.86" evidence="5"/>
    <dbReference type="EC" id="3.1.2.14" evidence="4"/>
    <dbReference type="EC" id="4.2.1.59" evidence="7"/>
    <dbReference type="EMBL" id="ML742551">
        <property type="protein sequence ID" value="KAE8144363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000169">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 29" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16 29" id="KW-0520">NAD</keyword>
    <keyword evidence="14 29" id="KW-0521">NADP</keyword>
    <keyword evidence="15 29" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 29 32" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1692"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="30">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="30">
        <location>
            <position position="1836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAE8144363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2090" mass="231938" checksum="ED444C148DD136CC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDY3</accession>
    <name>A0A5N6TDY3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_166608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742490">
        <property type="protein sequence ID" value="KAE8144542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDY3"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="530" mass="59662" checksum="2B2104CEE86A804D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE10</accession>
    <name>A0A5N6TE10_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_166415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742474">
        <property type="protein sequence ID" value="KAE8144615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE10"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="62"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="443" mass="48562" checksum="9CCB4A26617738FD" modified="2020-04-22" version="1">MSPSQNSTSSFAATARNRLASLSSQIMGTASPSVFSTSVVPAAPEDALFGLAQAFRNDPSDKKVDLVIGAYRDDNAKPWILPVVRKAGNIIHNDSSINYEYLPIKGLPSFTTAAQKVILGEDSPAIRDQRVTTFQTISGTGAVHLGALFLAKFHPQNPKPTVYLSNPTWANHNQIFTNAGLSLATYPYFDPSTKGLNFDGMLNGIRSAPAGSIILLHACAHNPTGVDLTQDQWKELAVVMRERHHFPFFDTAYQGFASGDLNRDAWAVRYFVEQGFELCVAQSFAKNFGLYGQRTGAFHFVSAPGATAKDDSAHVSSQLAILQRSEISNPPAFGAHIASRVLNDSTLFAEWEDDLRTMSGRIAEMRQGLRQRLEAKGTPGAWNHITDQIGMFSFTGLTEPQVKLLREKWHVYMTKNGRISMAGLNTKNIDYFAEAVDSVVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE86</accession>
    <name>A0A5N6TE86_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_88250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742455">
        <property type="protein sequence ID" value="KAE8144683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE86"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="121" mass="13702" checksum="22FCAEB8BE63954A" modified="2020-04-22" version="1">MSERFTPKVPVQLDPPRYDPITAEELSKCDGTDPSRPTLVAIKGIVFDVSKNSAYGPTGQYRVFAGKDPSRALACSSLKPENCKPDWYDLEDKEKTVLEEWFTFFSKRYNIVGKVENATNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEE0</accession>
    <name>A0A5N6TEE0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_88371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742458">
        <property type="protein sequence ID" value="KAE8144667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEE0"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="393" mass="44062" checksum="05FEF5AE235F2183" modified="2020-04-22" version="1">MNGFAAHGLDEDAFGDKSGLQGGLKTFDAFPKTKPSYQAPSRRGGQWTVLILLICTVFSVSEFKTWYRGTENHHFSVEKGVSHDLQLNLDAVVQMPCDALHVNIQDASGDRILAGELLKKEATSWKLWMDKRNYETHGGAHEYQILSREDAGRLEAQEEDAHVHHVLGEIRRNPRRKFPKGPRLRRGDTVDSCRIYGSLEGNKVQGDFHITARGHGYSDFQGHLDHSTFNFSHMITELSFGPHYPTLLNPLDKTIATTESHYYKYQYFLSVVPTIYSNGLSALDTYSAAPPKTGSKNLVFTNQYAATSQSTALPESPYYIPGIFFKYNIEPILLLISEERSSLLSLLIRLVNTASGVMVTGGWIYQISGWVGELVRKKTRRSEGVLTGKQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEV6</accession>
    <name>A0A5N6TEV6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rec8 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_89090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742468">
        <property type="protein sequence ID" value="KAE8144641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEV6"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="596" mass="65319" checksum="F16FEC173699BF16" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEZ8</accession>
    <name>A0A5N6TEZ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_165708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742411">
        <property type="protein sequence ID" value="KAE8144938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEZ8"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="3">
        <location>
            <begin position="52"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="498" mass="55922" checksum="4464BEE995AD59E2" modified="2020-04-22" version="1">MEELLSPLTSVSRRLHTSDPSDEDYDKQIRDLIIFLKDPGRASDISAVSGYALDKLDPSSHSLSYLFLLLHQINSTQFENKDLRPFDPTGALWPKIVRFLTSFDPFQIRYAGHEWRQLVELTVQSAQAVSKPLLAVPVIRDAILRLDPSSGVLTSIHITFIKLCLMSRSYSYALPILEKQICHFPTATSQTYQKHHKSILCGELEPSITFVTDSSGFSTKLTYRDYLQYFFCGAMIYMALKKWDKALHHLNIVICSPVTNAVSKIMVEGYKKWILVSLLACGKPIPSQSITSSHVMKVYQSLAQPYTTLADAFGKCDLQRLKVEVEAALSVWRMDNNTGLVYQVVDAFQKRTTLKLGKTFSALAVADVARHLPGRLSSLREVESFVASLVMCGTLDAVLLHLRDYSDSTMLRFSGTAKSRFLQENNVQGRILQECQSLRAMGKAVRDVNRGLELSNENFLFLQKCLKWSDNSGKGGINALEQTEGGFDLDEDIMGDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF05</accession>
    <name>A0A5N6TF05_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_165699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742410">
        <property type="protein sequence ID" value="KAE8144948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF05"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="120" mass="12968" checksum="6BCBD0A325292998" modified="2020-04-22" version="1">MSLQTPRVLPAHLHAFHPSNASAHVTNTVRILGTVTALRGDTATITCGNNGDVTLILKPDSHLQMGRLVEVVGKVADVDQGLGIRVLGTTDWGNPADCDYKIYENVVNATHRFKSVFYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFV9</accession>
    <name>A0A5N6TFV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_74156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742366">
        <property type="protein sequence ID" value="KAE8145258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFV9"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="596" mass="64541" checksum="D280F72ED8BD4E6E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG10</accession>
    <name>A0A5N6TG10_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_164933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742359">
        <property type="protein sequence ID" value="KAE8145315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG10"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="464" mass="51896" checksum="8EF5E0A95B297444" modified="2020-04-22" version="1">MSGPKAVAENMLWGGRFTQGLDPLMVQYNQSLPYDRIFWKQDIAGSIAFARANVKTGILSEQEFSEIERGFNQIAEEWSTNSFVVKENDEDIHTANERRLSEIIGKEIGGKLHTGRSRNEQVATDMRLWLRDELRRLDSILCDLIKVSIARAESELDFLMPGYTHLQKAQPVRWSHWILSHATAFASELQRLREVTRRVNRSPLGTGALAGNPFNIDREAMAKELGFEGLLYNSMNTVADRDFAMETMQWGSSFMLKISRWAEDLIIYSSLEFGFVRLSDAYSTGSSLMPQKKNADSLELLRGKAGRAFGQMAGLMVTIKGLPTTYNKDLQESIEPLLDHIKTVSDSIQIATGVLSTLTAIPEKMTAALAPEMLATEIADYLVRKGVPFREGHHISGRVVALAENTSVPMDTLSLEQLKTVDARFDDDVRACLDYERAVELKDAIGGTSRRAVLEQTSVLRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG96</accession>
    <name>A0A5N6TG96_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_164840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742354">
        <property type="protein sequence ID" value="KAE8145362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG96"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1161" mass="127278" checksum="160637659A5D29C8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGM9</accession>
    <name>A0A5N6TGM9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_164471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742336">
        <property type="protein sequence ID" value="KAE8145535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGM9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF46">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="56593" checksum="1999BA5B102345E9" modified="2020-04-22" version="1">MFQFMGTKRAFNWYISCVAAACMVLYGYDASVYNSVQGSANWEAYFHHPDENIIGAVNTAYTVGAIFGGFFMGGPIADFLGRKIGMATGCVLVIAATFMQTWSPRGNIACFLAGRCIIGIGQGIALTAGPIYIGELAPAEIRGKIMTFWQMFYSVGSFICFWVNYGCTEHKENLGEWDWKMVVIFQLLVPVLILALLPTIPGSPRWYIQRGNNIDKARAALAKVREPDEVEDELLKIREAIEYEKEAISGSYSALWKDKSLRKRMLLALIMNAGQQITGQGTLNTYSTKIYQKVFTSAGQIALINALNATFGIIFTLNAVWIIDRFGRKFLLIVGGIGMGICMIIVAAVETETPSPDGSKSTPVGISIVFLLFLFIFFYKPSWGATVWIWTSEVFSMNVRAQAVGMASQTQNVANAIVQQFFPTFLNNCGFYAFYMFAGINFLLAVFVFFFIPETKQVPLEEIDALFGGANHVTHGENLVVGEKQLQVTQSHRSDEKADVVAVENAPVRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH49</accession>
    <name>A0A5N6TH49_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_164711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="ML742347">
        <property type="protein sequence ID" value="KAE8145421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH49"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="266" mass="29292" checksum="4ABED0069D9AB627" modified="2020-04-22" version="1">MSSANIMSPTSSTTTPTWHQFERKVDEVRPSKTDINQLVMDYLITNGYPAAAKKFAVEANIQPKADVEAIQERVDIRTAIHSGDIQVAIEKINELNPQILDENPSLHFALLRLQLVELIRSCTSVPNGDITPALEFATSQLAPRAPTNPRFLEDLERTLALLIFPTENLTPALAPLLHPDLRKEIATSVNEAILQNQGACKEARLRNLVKLRAWAEQKAREAKKDVPDKLDLGLGDNAKDVKTASQNGSSNDSLMANNGDIDPMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THF7</accession>
    <name>A0A5N6THF7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_163806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742311">
        <property type="protein sequence ID" value="KAE8145814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THF7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="72" mass="8147" checksum="4620123074D6568F" modified="2020-04-22" version="1">MTTNSSLSRELQNLNFLKRQSRRGLASNYVVQLLDAFTHKGPNGVHQCLVFELLGPSVDKVHQNVLQQWGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY9</accession>
    <name>A0A5N6THY9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THY9"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="35269" checksum="9B1F7EF279D65454" modified="2020-04-22" version="1">MLRKRLFSTFRPLQHDNPLGLPRSGTPPTLRSRRGLPEKRKIRDVKKVIAVSSAKGGVGKSTIAVNLALSFARRGIRTGILDTDIFGPSIPTLLNLSGEPRLDENNCLLPLTNYGLKSMSMGYLLPQPTPSADHPTTIPMDTTPISWRGLMVTKAMHQLLHSVSWGPLDVLFLDLPPGTGDVQLTINQEVVVDGAVIVTTPQDIALRDAVRGYGMFQKMDVPVLGMVRNMAFFACPQCGTQTKIFSHGDGHRHEEDWGVVAECRRLGVQFLGDVPLDARVCEDADRGMPTVVAEESQDRSVRKKAFLDVAEQVAKKVGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIG8</accession>
    <name>A0A5N6TIG8_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_56692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8146050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIG8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069853" evidence="2">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="16603" checksum="CD3D74AA1D0F5F13" modified="2020-04-22" version="1">MTNITILFTYLCMLMLYAQSGLAAYIPADAPVGSVKSVSTRRHLSASVNPTSLSAQPSLSLYSSLSFQPNPSARPSRSVRSQAFLAGHSFSAAPSGLAPARLSYHPSLSNAGPSRSASLSVPALPSLSVHSNVSQRQTVSVAQTRARPSVVPSHAHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIH1</accession>
    <name>A0A5N6TIH1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_133163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742282">
        <property type="protein sequence ID" value="KAE8146174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIH1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002123">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
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            <end position="473"/>
        </location>
    </feature>
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            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="884" mass="99318" checksum="6F554B548B90D4E3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIQ8</accession>
    <name>A0A5N6TIQ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_54607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742279">
        <property type="protein sequence ID" value="KAE8146212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIQ8"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        </location>
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        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146212.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="938" mass="101975" checksum="EA258AC62AF93FE3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ47</accession>
    <name>A0A5N6TJ47_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_162592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="54"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="456" mass="49069" checksum="2A4221C44A855CDB" modified="2020-04-22" version="1">MAVFTDIFIYGMIVPILPEVLQTRVHVPVEELQKWMSIMLAAFGGAIFVGSPIFGYFADKGTSRQVPFIIGLLALGGSTVMFWVARTLTALVVARVLQGLSAAVVWTVGMALVVDTVGQAQVGAAMGYISMAMTVGTVFGPFIGGVVLSRIGYDAVFAIAIGLVALDIILRLFMIEQKTALKWTQPEAEDETAGLFDGSNQNHITAYQTTEQVSSDNVSIDQRHSVSCPDEIPGEAASSGKTSRVPPILRLMYSPSVLLVVGATVVDAILWSSFDTVLPLHAMKTFNWSPFWIGICFLPLFTPSFLSPQVGDAVDRCGARTIAFLGFLLDLPTFFLLRLITHDTTQDQVLLYVFLFIAGIASTLQIVSLMTEVSIVVERQEKETPGLFGSQGGTAQAYGLYNVAWSGGQVLGPLIAGLLSDLGGWVTMVTIFGVMSGLTAMMIAFSDAKVLRWIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ76</accession>
    <name>A0A5N6TJ76_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_163044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742283">
        <property type="protein sequence ID" value="KAE8146151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ76"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="435" mass="48556" checksum="AE36F161E9FB8E10" modified="2020-04-22" version="1">MTYYPYHTTTMDQVTQPEQMNHMHHVNRMALHDFVRLQVSREMVSHLAMQASQVIRCEPHVTTASAHGQPTPPSTPPLDAVDAQLPPLPSVEEFITSIVTRSQVQVPTLMTSLVYLARLRARLPPVAKGMRCTVHRIFLASLILAAKNLNDSSPKNKHWARYTAVKGYDGFAFSLPEVNLMERQLLFLLDWETRVTEEDLLCHFEPFLGPIRFRYELHERDMAMRQQPREWRRIQASADLLACRLRRQKLEARLDVRRSDSMHRRHRLPASPASSASLSSVSSNASPASLADTDRYQPYPPRRRPSNRSGSSVSPPSVQDVPSLSRVETVPSLSSRASSLAPSSRVATPASLRTSSSITSMNTDIRVVDGTRSPSAGGGYMSVPNLMHPHTKMEDTTQPTKKLRMSGHTGSTGFVARFLASAAGSYMGGRMRSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJP1</accession>
    <name>A0A5N6TJP1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_162150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJP1"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09299">
        <property type="entry name" value="TDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF3">
        <property type="entry name" value="ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="404" mass="44450" checksum="D8753218F168CE12" modified="2020-04-22" version="1">MAMDGRNNPPSPQLSSPASIALWNFSSQWFLIPQGSGILAIILHQLDYQFRGLEIISEVVWVYTIVLLALTVLIYLIRIIKYPRHVAKLLRSRVPEVSGLASISITFTTIIQMIALTITRDWGSSWGLVAFILWWINTAMAVIAVIGIPYIAIQLQSPNIECLTPSLLLPLIATLTSAAGGGVICQYGEINHRLQVPIIIVSYLEMSVGLLLAVVLDGIFLAQSSSRPREVDRYYQDMILCGPFGQGSFALQILGQAVGSGSFAQYARGTFLTAEAAAPVAFASQFLGLLLWGYGTFWWCFAVVRIIHALLAQPGGLRTSSFTMSAWALVFPWGVYTNAAVQLGKIMDAPAFKVWSTVLLLVLLIIWIANHIFTIKGLITGRILGLEHGWKFGRYGLQDDEKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJR2</accession>
    <name>A0A5N6TJR2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742255">
        <property type="protein sequence ID" value="KAE8146555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJR2"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39397" checksum="2913A892F420CC30" modified="2020-04-22" version="1">MSERSCEYADIFRNVARSRTSAPSTSSPAGSKAKDAPPSDAANANSSSHPEDPPVNMLHIRLIHHFMTEIRALFSDTVGTSMLLPGVMDACLSSPYVMNEALALSALHMSITRPAERDFYRHHAAQLQTHALTMLNSMDLQLNQETCVPLFLFSGVLNMHILCDALTFRDNDDFEQFLDHLARGFRLCHGIRAITGSSWVMLRESALKPIILDGEAQFESRSKLSHPESAKLLESIEKAKLGPSLTATYRKAIEALQAAVHIHSHENVGDSISKITAWPVLMPPEYIDLLMPRRPEALVVLTHYAVSLHFRRDIWVFGDGGRFLIESINQYLGPGWAEWLEWPMRVLNETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJZ1</accession>
    <name>A0A5N6TJZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_143580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ML742254">
        <property type="protein sequence ID" value="KAE8146580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJZ1"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="470" mass="49291" checksum="62E564605EE06EC4" modified="2020-04-22" version="1">MSPIIIVGSGLAGLSAASQILTHNIPVVMLERGAKPGGNSIKASSGINGVPTRFQLDSTDSPALFLSDTVTSAGGVFGNSTGSEKMRRQRLVEKLTGSSGEAVNWLVDEKGVELSRVCQLGGHSCARTHRGKGKLTPGFAIVSSLLESLKGSPLFEMRVGVRVTGVVKEAEEVVGVEYLSGEESGRVDGPVVFASGGFAGDARGLLARYRPDLAGIPSTNQAVEGTQPLLESVGAGLVDMEEVQVHPTGFVDGGDVEAGVKILAAEALRGEGGILVVGGKRFVNELETREHVTGVIMRDARRLETGTRQWDVQVVLDEGAAAALGSHMDFYLWKGLLKKAAVGELEPELQSTLRTYAGVVSGETKDEFGRTAFGHWGLREVTPDAVVYVGQVTPVTHFTMGGAAIDERSRVLSNQGVPIRGLWAAGEVTGGLHGQNRLGGSSLLECVVFGRIAGDEAAAFYKSHYSSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK56</accession>
    <name>A0A5N6TK56_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_161957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742246">
        <property type="protein sequence ID" value="KAE8146717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK56"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="149" mass="17169" checksum="ADE9EF93A5187C64" modified="2020-04-22" version="1">MARQSDRAGDVGEAIPLRRHRSSLEGAIYPAPQRLALEKHVEAINVFDRLIQHFEPLQASNKNYKPMTLLRLMKEEVSSEDEFLVLFFNHIEPGELEVTEASLPKTLARLHSFQEWAFEERDALNQSLANFASFLVDNFFLSRMSLIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK63</accession>
    <name>A0A5N6TK63_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_169661</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="ML742245">
        <property type="protein sequence ID" value="KAE8146732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK63"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8146732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="36446" checksum="9A45F6E5BAE15571" modified="2020-04-22" version="1">MALGRKFKLNTGYEIPALGLGTWQSKPHEVEHAVAEALKHGYRHIDAAAVYLNEREVGNGIKTSGVPREEIFLTSKLWNTHHDPENVEAAVDKSLSDLQTDYLDLYLIHWPVAFRHSTTTTQPVDEETNLIDVIDVPIKDTWGALEALVAKGKIRSIGVSNFTRGKIEILLKTAKIPPAVNQIEAHPYLQQRDLLSWCREKGIVITGYSPLGNNIYNIPRAVDDSLVIETAKKLGKSAAQVLISWAIQRGTVVLPKSVTPERIQSNFEDFILPDDAFQSIQSLERHQRMNFPARLGVDIFEEVGEESVKKSAREWAEQQRKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKL6</accession>
    <name>A0A5N6TKL6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aegerolysin type hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742237">
        <property type="protein sequence ID" value="KAE8146887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKL6"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="140" mass="16226" checksum="37B9212C2C063353" modified="2020-04-22" version="1">MDMEMNKYNSKWVEFHIRDHLENGEISVRHTVIEDGEFHNPHDRRKSIHEDEIDDIVIPADGIGEICAHGRRGSEGRLDLFHGDDKICELHWDNREGKLVNLVETLDKSAKYRVEHGGWSPEAGPLGHVYIDVWAKNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKX7</accession>
    <name>A0A5N6TKX7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_143386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742243">
        <property type="protein sequence ID" value="KAE8146769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKX7"/>
    <dbReference type="OrthoDB" id="4526527at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="268"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="394" mass="43866" checksum="BB032C067A8A798A" modified="2020-04-22" version="1">MASKIPLPQFKGPATAEAITTFFQECDTQFEDYEDFEATTLPDRTKIRQAAKAFGDDADMEDDRSKGLKDWYALKRTDLDSGSWDGFKDELKAHLMGPTWRLQILKDFFTHEQNGFGLDEYVNLYNRRRLNLSRTSKMPAVTDDLYKCLLLFRASQSTYENLLDDEADEQWLLSAKVSDLLLKLKKYDSGKQPGSGGDGSGQNGSGQNGSSPSPLSYPQLTAAQTPYMVSTLYSKTASEIGLTATDASTHLNGLPDNPRSLGHLRRVVTKINTSTQLPTVQRLGVDYAGVPWLWAGSESHNNQSYDFNIDAGDYLKSVQVTRRTWLSAVVHVQYTTAKGKSQSYGTSGQEWTTLTAPDGWRIVGFHAMAGSLNRYSTDWHLTAKLGVIYAPIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKZ8</accession>
    <name>A0A5N6TKZ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742243">
        <property type="protein sequence ID" value="KAE8146761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKZ8"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="110" mass="12407" checksum="D93DDD21E706E76E" modified="2020-04-22" version="1">MSFHLSSQNFRLSFEEGCTVFECEVRDRHGEFHHRKIKLDAHIGNTDGWFIWGGQNFTRTARDIRLEQTGNGPKLIATMQTNSGGDRGAQGLMLADKIENNDGHLRFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL03</accession>
    <name>A0A5N6TL03_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_143146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742230">
        <property type="protein sequence ID" value="KAE8147033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL03"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="194" mass="20860" checksum="FC993763604DBC43" modified="2020-04-22" version="1">MTSKAALTRSNPQGKPASTAGVPNQTLYCTNLPDKLRKYDLRLSLYTLFSTYGTILDVVAMKTKRMRGQAHIVFKDVQASTQAMRALQGFEFFGRQMNIVYAKGTSDVISRLRGTYNISAIAAAQTGGTSTDLQKSIFSGPPGSTALPPRPTGETNGGNAAQGVKRPREDESDGGEAPMDEESDVPMEDSSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLF3</accession>
    <name>A0A5N6TLF3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_161492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742235">
        <property type="protein sequence ID" value="KAE8146921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLF3"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025010843" evidence="2">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="154" mass="18184" checksum="4DECE2391E191AE8" modified="2020-04-22" version="1">MNLLTTLFTFFLFLSANALQATPLTMLTIKGYILPNLTESEYHHHLTTHHVPLVKPFLRKYNILRYTLTHQTQAMKEARKRLRLPPGTEDYDVMVQFLMRDVEDFNRLWEDEEFVRTVKPDQGRLLDEERNVYTIGVYETFMDDVDVGGEMVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLQ3</accession>
    <name>A0A5N6TLQ3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLQ3"/>
    <dbReference type="OrthoDB" id="414322at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="403" mass="45651" checksum="46EE6D58A2C1EA95" modified="2020-04-22" version="1">MIEKEEKKITTILTTSPTPSLPSTELISSILHSFTTHCPRLLKSPIIVVFDTTDKISANPRLKRGEASLDTGEKYALYRENVKRLVLSCYSHCPSQENRDPQDERESQESQNYQGGTGTSESGTTTTDTDTEVDEEEEKEDMKKWTTKAEYGLPYPTNEVELSITQTKNGGVTFITPSTRLGFGLAVRSALRLVQTEYVWVQQHDWVLVEDIPVADLLGVMSLSSSSSTSSSSISQETSITGSTGSQSSEEKEVSPTEENIPIKYITFPSIRTLTYTKQPYVLDFPLLRNYARTLTGTFTAPSGAEVPLTPLFFWFDKPHIAQTKHYLERVFPNRLAMRRGEFIEDKIGQVARGQMKEGLWERWACWLFYPEDGRKLCLRHLQGRTWRGEEGDLLRRFGYGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLV8</accession>
    <name>A0A5N6TLV8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_161084</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="ML742226">
        <property type="protein sequence ID" value="KAE8147081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLV8"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8147081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="374" mass="40655" checksum="3D94ACB89E424C0B" modified="2020-04-22" version="1">MSFSNLISDLAFRDNHDDRSSQISHVRSQATARSYTSTAATSVSISGDISSQLHAGYSHPLSRSWQAERQLTKEMLIYPLFITDNPDEETPIPSLPGQYRRGLNRLVPFLRPLIHKGLHSVILFGVPLHPSAKDALGTAADDPSGPVVQAIRLLRSRFPQLYIVTDVCLCEYTSHGHCGILREDGTLDNAQSVDRISDVALAYAAAGAHCVAPSDMNDGRVRAIKLKLIESGMAHRVLLMSYSAKFSGCLYGPFRDAAGSCPSFGDRRCYQLPPGGRGLARRAIQRDIGEGADIIMVKPASSYLDIIRDAKELAEDIPIAAYQVSGEYAMIHAGAKAGVFDLKSMAFESTEGIIRAGAGIIVSYFVPDFLDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMH0</accession>
    <name>A0A5N6TMH0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_132004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMH0"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="449"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="558" mass="62005" checksum="9E80F8D9FBDA4558" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN41</accession>
    <name>A0A5N6TN41_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_159688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN41"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="152" mass="16519" checksum="6956A41D9716769E" modified="2020-04-22" version="1">MSETARLKCTVYVGGLDQAVTVQTLAEAFVPFGEVVDITLPKPDVPNSNELHRGFGYVEFDLPDDAREAIDNMDGSELYGRTIKVAAAKPQNDSNEGLGSKTAIWEQEGYLAKYAVSEEDKLAAEQAQMASDRPQDPMQGLEELDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN89</accession>
    <name>A0A5N6TN89_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Opsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_168874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742191">
        <property type="protein sequence ID" value="KAE8147775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN89"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32525" checksum="39915C7E63A21FE1" modified="2020-04-22" version="1">MIEFDKVPVPTSTPTSVAPVPTVFPGNDPVFQELTKTSQRTLWVVVVLMALSSVVFYILGARVPLSKRILHTTMSISTTISFILYLALATGQGITYKHDTLTTHNAHVPNTHDDIYRQVLWLRYLNWFLTDPLILLNLALLSGLPGAHLVSGIVADWIMLGAGLLGTFAGHTPKRWVWFTIAAIAYLTNVYHVGVHGSRAAVNRDAQTKRFFGTVAGVGLLVKVLFPVALAAGALALKINIDAETIVFAIHDIFLQGILGYWLILAHDASPGINLLVDGFWSHGIGNEGAIRITEEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPA4</accession>
    <name>A0A5N6TPA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_142027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742171">
        <property type="protein sequence ID" value="KAE8148183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPA4"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="95" mass="10501" checksum="322DF1D774BB569E" modified="2020-04-22" version="1">MVPYRSATARIKRAVFRDIFDQGAAHVGVPGPGSTKLGGLDKRFSNDIPKIELSGPQHLRLSSTLPVLFTTEVDKIIPWFIERSIADKPTIILQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPL7</accession>
    <name>A0A5N6TPL7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_20721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742169">
        <property type="protein sequence ID" value="KAE8148227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPL7"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="102" mass="11240" checksum="D06BBCEBD55BDA2C" modified="2020-04-22" version="1">MNNFLTSIQDVFEGQIDFHGQRIAELLSTAFLIVSGVAAFLTGYIYQDIHLTLWVGLWGTLTAGLTIIPSWPIYNRNPEKWLVTLAGSASSARVMVDGVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPW8</accession>
    <name>A0A5N6TPW8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_21207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742171">
        <property type="protein sequence ID" value="KAE8148179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPW8"/>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
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            <end position="487"/>
        </location>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="118"/>
            <end position="179"/>
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            <begin position="211"/>
            <end position="387"/>
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            <begin position="480"/>
            <end position="627"/>
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        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
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        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
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        <location>
            <begin position="49"/>
            <end position="63"/>
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            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="151"/>
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            <begin position="226"/>
            <end position="245"/>
        </location>
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        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
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        </location>
    </feature>
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            <begin position="320"/>
            <end position="335"/>
        </location>
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            <end position="380"/>
        </location>
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            <begin position="494"/>
            <end position="507"/>
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            <end position="538"/>
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            <begin position="546"/>
            <end position="561"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
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        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="897" mass="98051" checksum="BB1BA1C09A4BE988" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQG7</accession>
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        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_131072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742153">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="80150" checksum="A6A7496D5620A56C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR33</accession>
    <name>A0A5N6TR33_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_15533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="ML742153">
        <property type="protein sequence ID" value="KAE8148601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR33"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="545" mass="57712" checksum="80B6B2D5ABDAFA86" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRK5</accession>
    <name>A0A5N6TRK5_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_141284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="508" mass="56276" checksum="1E6A030BF6DC4412" modified="2020-04-22" version="1">MDNDSESNPFATQLALAVAIVKHKPVHLSIREYILQIREQIKDVKATSSSYVRDRERFFDSVSFWRGAYEKSEAEQSKLLDRIYDLERRNEALTAKLQAREVPYEDQSSLKRKGAAGKKVVTARKRAKTQMGSGSLSTGVGLQDAFGPLHSLEEGTTLFLRQVYILQKALQKRNGELDVTKAVACLCKTAADELSRAILRELAVGESKKKATLPTTQPKVSEVLRGIECASGLLLQALRSIPQSEPPNQCSGHITYHIVSLFDSIMDALQQWCAARSDLVHSASASKQKRRLPRKNVKDGLNVTDTKGDQVSDELAHLLGTIIGGIDTPCSGHRDLLDGLLFILISRVGKLICLFVFQDLMSKPDLRTDSVELPLPSGLTESETNDNTFHAAGMEARRLAWLLERALAVLRTAPSPMTPSSLNNCEGVLFGIILKEKLQGTLLQAVFGSDPIWGKTFQRSVEPDSGDWNGIQTSENTDQPSSDWFIQEIWRLLGWDILMKSSPSKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRT2</accession>
    <name>A0A5N6TRT2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_141171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRT2"/>
    <dbReference type="OrthoDB" id="4483681at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="12159" checksum="029D69118E97CF6B" modified="2020-04-22" version="1">MRQELSDFPSRYTYNGKIINGLWASTQSMVIPPAFLNALKQWIQSMYPKANLDRIDWYAPGFNVKRNFNREFKNMSRYNARHAKRPLLLVLHTPGTMQAGPASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSP3</accession>
    <name>A0A5N6TSP3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_140881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSP3"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="293" mass="31396" checksum="910B356492C85A4E" modified="2020-04-22" version="1">MSGEHNTDYEKDISPGNGHDFANGANGATATHQMSAEDTARAAARFGYGPLAHVNTTEAQLRPFGGEFQPGLYKSVEHRKFGNPAPLGLSAFALTTFVLSLINMGARDIAEPNIVVALAFGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWISFAIVLTPGGFEIASSLGGASDPMFNNSFGLFLFGWFIFTTILLFCTMRSTVAFFLLFFFLDLTFLLLGIGYVHRNAEGKPNPPVIKAAGLFGLLAAFAAWYNALAGIADSSNSFFIIPVAHFPWSPTARSRKTERQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTD3</accession>
    <name>A0A5N6TTD3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_130265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTD3"/>
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        </source>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
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    <sequence length="673" mass="75479" checksum="FA2DB94F3E74CB18" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <name>A0A5N6TTG7_ASPAV</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BDV25DRAFT_156008</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
        </source>
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        <text evidence="1">Belongs to the Gfa family.</text>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="28517" checksum="A8A5E6ED263AC6CC" modified="2020-04-22" version="1">MLHQIRTAAVLPAFSRSAVTSLSKQGGRPIPSGKHITPFISYRTFGITPEMAEDVSMGGDPLPNPISGTTHKERWKLRPPYKIQSDEEFGPVQWIGRCQCGQVEYKLNREKPLKSKYCHCRGCQVLHGSPFQWAAIFHKSDMTFTNGTSGLGFYSSTEKSQEYQTPTKVSCSFCRTPIMDEGRNVCLLFPGSIDYGESHEQRERWVKAFEVECHIFYSRRAIEIPDGKPKWSELDESSDLLDDKGNLKKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTQ1</accession>
    <name>A0A5N6TTQ1_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">DUF1709-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_140770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PH_Bud4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AHD"/>
    </dbReference>
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        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1283"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1283"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1353" mass="150694" checksum="EFA1CC3E876FF502" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTS2</accession>
    <name>A0A5N6TTS2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_155705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTS2"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="373" mass="42299" checksum="402EB7BD2104E774" modified="2020-04-22" version="1">MAPLIPSQEELDRRRIVDINPETVSNIPSTDFPGHWPGESHEWSLDKFSEGFNVEFHRNERFESSFSLVGLDASIANAFRRILMAEVPSVAIEYVFMNNNTSVIQDEVLAQRLGLIPLKGSVDGINWMRWFKKPTEDDPEGSNPADFNTIVLRLNIECTKNPNADPEEQDPRKLYNYAHVYARDITFHPVGRQEEFFVGDDAIQPVNPDILIAKLRPGQKIDMEMHCIKGIGADHAKFSPVATATYRLLPDIKILRPILGEDAQKFAKCFPKGVIGLESVTQEEAAKQGSGYEGHAGETKAVVRDAFKDTVSRECLRHEEFQNKVKLGRVRDHFIFNVESVGQFESDTLFLESVKVLKLKCARWKRGLTDLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU15</accession>
    <name>A0A5N6TU15_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU15"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="12028" checksum="5AA84A99EC0BB38B" modified="2020-04-22" version="1">MSATPMEDVMRTKINEAFTPSTLIIRNDSHLHAHHAPMRDSTSQETHFHVTITSESFKSKMQAARHRMVYGLLKDEMSQEGGIHALQLRTRTPEEEQREKERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUA0</accession>
    <name>A0A5N6TUA0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="ML742116">
        <property type="protein sequence ID" value="KAE8149661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUA0"/>
    <dbReference type="OrthoDB" id="4662583at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024968716" description="Indoleamine 2,3-dioxygenase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="455" mass="52047" checksum="2D35EF709534D6F9" modified="2020-04-22" version="1">MSLFLLPFPFIIALLLVLAWRRRTQRLKADATAWQIQNIKSMKRQGAHETATLLADLIENDGAGAWPPKTNYGSWPEPLRAYKDIYLELVPTLPAANPSLDDDVNQEKRNKYRMRMRKLLSERVDIVGVEKLMIAAAAGDTDAFPRDVYNAFYCCIAVCRHAYRWATIPVVKVAQLEKIVDFPPELDVPWPYLQRSFRVDADSGNNTANVLHNFDENGERVFKINVGLNELITSSEDAFFRLFYDLEVLAMPIYYDMIRAVVCFEENDTVSCLTHLQNITFRVRTLLKVFYDGLTASRVSKEVWLSYVQGFQGWGVGRMINGEYVKFDGLSGNHVLIFQALDAFLGIGRYLSDENMDRYIPGRQRDLCVALKKHSFRGKLKGPMDCQIEEEFKKIVNHMKLFRSAHRTRVMPYLEQPAPERLTMTAGKSVLEGPDAKSALKVLDDMLVTRLKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUE4</accession>
    <name>A0A5N6TUE4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_123485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742115">
        <property type="protein sequence ID" value="KAE8149701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUE4"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000652">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="60"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128576" checksum="CF25C4F280397BF0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUN3</accession>
    <name>A0A5N6TUN3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_155261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="13"/>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8150000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUN3"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000119">
        <property type="entry name" value="Probable beta-glucosidase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="14">
        <location>
            <begin position="395"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8150000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="839" mass="91845" checksum="7424EB51C2B8289A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUN7</accession>
    <name>A0A5N6TUN7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Smr domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_155583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUN7"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="465"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="59712" checksum="8EB87B2453FD002B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUY9</accession>
    <name>A0A5N6TUY9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_155077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUY9"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="100"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="327" mass="35786" checksum="CC1E48DF8C00D065" modified="2020-04-22" version="1">MASGTETIRIGYVPEHYLTPLHLALRSPALASLPFKISLVPFPSGTGHMITSLREKEIDLAIGLTEGWVAGLAGKQQAQKDAASGGYKVVGEWVATPLRWAIVTGRERQDIHGVADLKDKRVGVSRLGSGSHIMSFVLAQQQGWKSDSLTSVPLGPFQALRNGVTGHDDSQPEKQPEPTAEFFMWEHFTTKPYFHATTEKHQPPLKKIGEIYTPWPSWMVVASTAVFPDPEVDGKLQQLFKLFDQGISDFEADTAQAVKLLGTGELGCTYGEEDAKEWLKDVKFVQGTKGVDRKTIEGVVDVLKVAGVIDNGMSNDEAVQRVVGIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV42</accession>
    <name>A0A5N6TV42_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_154857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV42"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31322" checksum="A4E1E40BC6BDA886" modified="2020-04-22" version="1">MAPPANLPLAERLKALAQTLQFAWFAGHVTLLLSVFRYILSYITFNYYSSSAQVSYRLAFLSAAATYGIVVYKGHIARGRLQGSVPNIVMKLAGDENVQYLVMAIVWLYSRQIPLALLPFSVYSVFHVATYSRAHLIPTLQPPAQGAAGPTSPSSPSAPKPTANPIADTIGRFVKQYYDASMDLVAGLEMALLFRLGLSILTFSKGSILLFFIYVVFFRARYAQSAFVQQAVRHFTARVDASVSHQSTPPALRQGWETFKGVVRQVYDSTDLGRLTSGATGKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVB8</accession>
    <name>A0A5N6TVB8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_154814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVB8"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000047">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="483"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="691"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="917"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="932"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1129"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1147" mass="129995" checksum="3E484E514AFF19DB" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <submittedName>
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        <name evidence="10" type="ORF">BDV25DRAFT_154096</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">IBT 18842</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="208"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
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            <end position="512"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWF2</accession>
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        <submittedName>
            <fullName evidence="9">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_112545</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
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        <property type="protein sequence ID" value="KAE8150401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008374">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="339"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWN9</accession>
    <name>A0A5N6TWN9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
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        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171917</name>
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    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWN9"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025030445" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="577" mass="64640" checksum="10AC756B62FA13BE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWS0</accession>
    <name>A0A5N6TWS0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWS0"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37266" checksum="B319D86E5C097DF3" modified="2020-04-22" version="1" fragment="single">MMHAVWTNLLADASIRRSSHTLSIIDNDAYIYGGELRPREPVDSAVYRIALGHEVSPHEKITTITSTTVVPPPRVGSASTTLHGKIYMFSGRGGLAMAPIEEAGAFWVFDPVGNVWSQVKPADSHAPYPVGRSYHTLANDGNNTIFLHAGCPEKGRLRDIWAFNLATRQWRELSPAPPPERGGTSLAYAEGKLYRMNGFDGNREQGGALDVFDLEEDEWETVTYPADGISGPSPRSVSCLVSLKILGKPCLVTMFGEHDPSSLGHQGAGKMLSDVWIFDIKTQIWTQAFVDGNNRPPARGWFDADVVTTYSPPCAIVHGGLAESNDRLGDMWRLNFKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXB3</accession>
    <name>A0A5N6TXB3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore protein Mis14 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXB3"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="276" mass="30413" checksum="A89759F91B6E1D15" modified="2020-04-22" version="1">MHRKIELQAPADFTYLHANTVALSRKKLDLHLPPSANPNDGPDPMRERVRELVEEFITRTFTSASSSISINGLDSSSSQFPFPASFTAPTETVEYEPFDGRLASRVTSLYAQLESLTTTVAQLRRDAPQRAAETYAAELRKAIEEDEQDDLDDADFLEGDDRGRATEDVDMPDVDQQSKHTPDDGTNADSSRKTSSKARWDLQVPLGTDHEAERWRTGEMAEVYEDALRTLLRLQGEAVPGDETSGAEGATDDNAVASTIGKAERAGRAVEVVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXF9</accession>
    <name>A0A5N6TXF9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_153387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXF9"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="36113" checksum="680E8491DC29E079" modified="2020-04-22" version="1">MHLNHKIPWNTVSSHFLFVKENPYKNRETDFIIHDRLVDCQGGELKYFTGALIAAIEEFATTERAKYPAPKDLPKAGPLFDASVLTSVEQKYHLEPHRTNSATSNPLCENFRDVEIWIKHAPYSTKDGDLADAVKMLLVANEMVALLRLANHEKVPLVTLDNLHWGHSFGVRHLADVALEAYLLLNIAAAVKANAKSGSANESVCLTRTKRFKTFTNWALADFDYPVQNIPHRLFWGARSITDNHIGDWDPLSLQTDQERKELREYLKMCFELLYRYDLLMKEMGCDPDWNEKILGILRMWGAKSVVFTETGYGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY44</accession>
    <name>A0A5N6TY44_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY44"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="87" mass="8230" checksum="F4FCAEB09B4FCAB6" modified="2020-04-22" version="1">MSSNDTNNSIADLLAGLLGGVGNTLGKTVDGVTGTLGTAVGGLGKTVGGATEGLGKTVSGTSEGVENTTKGVGESTGGIFSSGEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYJ3</accession>
    <name>A0A5N6TYJ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear fusion protein KAR5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_138908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYJ3"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025052380" description="Nuclear fusion protein KAR5" evidence="12">
        <location>
            <begin position="29"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8151385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57355" checksum="3B9FBF182EB5E809" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYY1</accession>
    <name>A0A5N6TYY1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_153012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYY1"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="520" mass="56917" checksum="5A3DDCECE2762925" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYY7</accession>
    <name>A0A5N6TYY7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_171384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYY7"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="39998" checksum="A6B270E872124542" modified="2020-04-22" version="1">MSTPFRVEFEAFFDSLRSDLIESISDMSHFPSLPANVIDRMDKSLAMNARGGKYARGMTVIDTATTILTKPLTQDTVKDLFMLGWVIEIQSAAILVIDDIMDNSTVRRGKPCWYRRPEVGLAATNDACLLHSITFWILNKYFRTHPGYVDMVDLMHRSNLITEIGQTYDNIHTPPGLQGFTREGYNALITYKTGWFGFTLPVVLTLHYLGRGNPVNVMQSERLVVALGNYLQVQDDFLDVFGDPAVLGKVGTDIQENKLTWMITEALELCTVQQRQELETHYGVRDVESERKVKDMFKEIGLEKRYAEYQENVIDNINRMISDVDESEGLSKAIFERILSKCVKRNKWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZI1</accession>
    <name>A0A5N6TZI1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_128561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZI1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="354" mass="38556" checksum="681328548C9B9C40" modified="2020-04-22" version="1">MKAVRFHGRGDIRVEEIDEPICGDGQVKIRPAFVGLCGSDIHEFTAGPVLVPEEPHNITKRSSPVTLGHEFGGIVEEVGDGVTHVSPGQRVVVRPTIFDRDCAACKRGYEYCCENIGFIGLSGYGGGLAKYHVAPAEHFYAIPDDVSLEAAALIEPLAVAWHAVQTSPFKMNDSVLVIGGGPVGIGIVQVLKLQGARHIIVSELYEKRRRFAIQYGATHAFHPGEENLVQKVMEITGSIGADVVFDAAGVERALKDAVSSCRTHGTIVNVAVWEKEPVVPVNKLMYNEVNYTGSALYDERSFVAVIKALEYGQLKPERMITAKVKLTETVEKGFHTLVNDREDHCKIVIDVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZK6</accession>
    <name>A0A5N6TZK6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_128595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZK6"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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            <end position="364"/>
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            <end position="483"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="565"/>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151714.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="653" mass="73694" checksum="B2622FCAE9ED3282" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZQ5</accession>
    <name>A0A5N6TZQ5_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Endosomal peripheral membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_138455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the MON2 family.</text>
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    <dbReference type="EMBL" id="ML742063">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mon2_C"/>
    </dbReference>
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        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
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    </feature>
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        <location>
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            <end position="1220"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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        </location>
    </feature>
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        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1710" mass="189458" checksum="D5F8A5D9737B9019" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZS9</accession>
    <name>A0A5N6TZS9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_152054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742063">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="600" mass="67507" checksum="9FD0F83B4A194283" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U066</accession>
    <name>A0A5N6U066_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">alpha-1,2-Mannosidase</fullName>
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    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_128369</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="17"/>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U066"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8151990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="578" mass="66724" checksum="CBE1E088F1277164" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U084</accession>
    <name>A0A5N6U084_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_78950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U084"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="169"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29229" checksum="D8C3BDD53D74530B" modified="2020-04-22" version="1">MLPSQLNSSPKRANPFSRVSPSPSHSPSPAPKTGRPKSALVTSTKFEEARGHFRNPSSLTPSVQPPFIRSANRQRANSLRNDVSSGTFAPEFIKSEELQRGADQIRGLEGDNDFSGNKYVWLRDPEKAFIRGLVLEEGDNGTLLVQSDDGEQREVDADQVDKVNPAKFDKADDMAELTHLNEASVVHNLHTRYQADLIYTYSGLFLVTVNPYCPLLIYTNEYVKMYKGRSRDESRPHIFAMADEAFRNLVEEGQNQSILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0U6</accession>
    <name>A0A5N6U0U6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Arginase</fullName>
            <ecNumber evidence="3 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_138070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3 11"/>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0U6"/>
    <dbReference type="OrthoDB" id="4489634at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="317" mass="34662" checksum="20D861373D8567A2" modified="2020-04-22" version="1">MIHQAHPPKFVKSSHLAVFAAKVSCGAPRDGAQGGPDAVISSGIFHEMQSKSKLTMTFDVHNDENEGYPESDFHGMKRPRAVSNATQHISDLVYDQAREGNFVLTLRGDHSIGIGTVSGVAKAIRERHLGREIGVLWIDAHADINTPETSLSRRIHGMPVAFVSGLVKVRLQGVFDWLEESYLINLQKLVYIGLRDVDDAERDIIAQHNVKAFYIDDVKRDGIQHIMDTALDHLGSETPLHVSYDINSLDPNWAPSTVFPVEPGLTREEGVYVAKRLAGTGQLVAMDLVEINPQIGPSKLGVTVESGCSVIKSALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U148</accession>
    <name>A0A5N6U148_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_137915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U148"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025051930" evidence="6">
        <location>
            <begin position="22"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="516" mass="55372" checksum="6665C6D1C476E874" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U157</accession>
    <name>A0A5N6U157_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_170514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8152377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U157"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="663" mass="75004" checksum="0EBF7BC2CDDC5BAF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1F7</accession>
    <name>A0A5N6U1F7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_128048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1F7"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="348"/>
        </location>
    </feature>
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        <location>
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            <end position="378"/>
        </location>
    </feature>
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            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="472" mass="52123" checksum="058A258F516B7B94" modified="2020-04-22" version="1">MFTCLNTPRVSLDYALEAQGLELKSNEKDIVRWSATNPRHPRNWSPLRKAYDITIIILLEFYTYLLAQGIGSVIFPPYSECFGRKRLYVGSTVIYSVFCAVIGASSHPAAAAVGRTITGFLSAVPSVVIAGSIEDMFSTRERIWLTLPYMAVADFGIASGPVMSTYITAAWGWEWVFYVSAIVTGILAIFLCLIRESRPTLILEREVAQLRKATGNESLEALNPDRVLDLDTFLRNVVFRPAQLLFSEPIIMAVSIVCGVSSGIIYLFTDVLPPVYASFGLSTTTASLPFLAIGFGFIPNVLTRFLEYRMANKRVARNEPVLPEHKLTGYVIAAPVLMGALWWFAWTIPPAVHIHWFVSVVPLFFIGFAINEFGIVLVGYMADSYLSFSASAFAALCLVRCLLAASFPLFTGRMFDALGPNVGVSVLAVVATVFCAIAPMLRMFGERLRKKSKFASYSLKVHNENTAEKTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1J1</accession>
    <name>A0A5N6U1J1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_67961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1J1"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024807477" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="235" mass="26208" checksum="6878C12F9D678341" modified="2020-04-22" version="1">MFLHYLSFLLTFCLVAYANVEKTIFLAPHTLTVPTVDPTLDDLGLERLSPTNPVLRTKLNASFPTTESQGTESWYFLEHLTPGRRYEVRICWLATQPTAFSLDTHTVTQAVETPDIFSSITFYSQARLASPSNVVPRQPSTIHDQAPTSDSVLFLRVTAAADYFSLDQSLMENVPPVVADIILDPFLFNVFPQSLIPTACYISLVACLAVFIGRWVLGQFDKAIDSTIGQKDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1M0</accession>
    <name>A0A5N6U1M0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_150859</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1M0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="359"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8152567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="663" mass="74087" checksum="ADF20C20073A89AC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1P7</accession>
    <name>A0A5N6U1P7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1P7"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="161" mass="18921" checksum="F9B1C33D3A22E028" modified="2020-04-22" version="1">MDKIKERMNALRLEAEDAQEKVEDLKARVKTLEQENLSKEQEITSLNHRNQLLEGEVEKLENTVKEAKDAANQNAQHDTQNESLQRRVQLMEEELEQADRNLRETVEKLRQTDVKAGHYERKVQAIESSRDEWESKYEEMAKKHAELQKDLHDLEVSISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1R0</accession>
    <name>A0A5N6U1R0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_137686</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ML742050">
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    </dbReference>
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        <property type="entry name" value="RmlC-like cupins"/>
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    </dbReference>
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        </location>
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        <location>
            <position position="106"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
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        <ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
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        <ligand>
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            <position position="257"/>
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        <ligand>
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        </ligand>
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        <source>
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        </source>
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        </source>
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    <sequence length="406" mass="44810" checksum="3C452136651A1F91" modified="2020-04-22" version="1">MAEQVVQLRCGVKNDPWGKKGRSSVAGQLWSKTPGNGTVQDSEPYSEMWMGTYPTVPSRVLSTGQLLSEYLQENPELVGKAVIDKYGPEIPFLPKVLSFAKALPLQIHPDKALAEQLHKENAQEFGDANHKPEIAVALSNFELFAGFKPLHEIEAIMKLKPLEQLVPVNEPFDDDTLREISKTLLTLPPIVVSEIINSLRDLPEAQFGRHRYIPGMLDRLSKQYTEFDNGNLVAVLLMNYMTLGPGEAVSVPADSMHAYLCGDIVECMARSDNVLNTGFCPRAQRDSVELFTRALSFNPHGVDAALLLRKRSSRGVNGKSDEYAPPFSEFNVLATILGAGEHETHKDIAGPSLLFVTKGCGRMEVAEGKSVKSYDLQEGYVYFVGQGVRLDLSTDKGIAIYRPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2K7</accession>
    <name>A0A5N6U2K7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_137568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
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        <location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="667" mass="74787" checksum="BD7912F14A3A52F4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3D4</accession>
    <name>A0A5N6U3D4_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_137217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071677" evidence="3">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="585" mass="49323" checksum="66F0EF10FB8CC1B3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3E6</accession>
    <name>A0A5N6U3E6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_42517</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3E6"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="239"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8153145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="43752" checksum="5AD68A7C24F1AEE6" modified="2020-04-22" version="1">MSSFSSIDSLFNSLIAHLSALPSSSCCDPVDLSMASTVGQTITCKAAIAWAAAEPLSVEDVQVAPPKAHEVRIKILHTGVCHTDAYTLSGKDPEGAFPVILGHEGAGVVESIGEGVTNVKPGDYVVALYTPECGECKFCRSGKTNLCGKIRATQGRGVMPDGTTRFKARGKDLLHFMGTSTFSEYTVVADISVVTVTPNCPTDRSCLLGCGITTGYGAATVSADIREGANVAVFGAGCVGLSIVQGAVKQKAGKIIVVDINDRKKDWAFKFGATHFLNPANLRKPVQDELIEMTDGGCDYTFDCTGNVSVMRAALEACHKGWGESIVIGVAAAGQEITTRPFQLVTGRVWRGCAFGGVKGRSQLPGLVNDYLRGDLKIDEFITHRETLANINDAFELMKQGDCIRCVVDTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U470</accession>
    <name>A0A5N6U470_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_136892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U470"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="224" mass="24992" checksum="62C317C81C6AA75F" modified="2020-04-22" version="1">MDTEAEIMFNEIAPNYEATFAHDPSLHQVIGQALDLLEPSSRVLDVGCGTGKPVSYRLAGAGHDVTGIDISQNMIDIASRQVKGTFTKVDMTKYQPGTKFHCIFAVFSLFNLSRAQTQSLVRKFFEWLVPGGRLVLATIPSDCLFQDPSVYDHSGEWVDQKPMYFMGHDFCGSAATTGAWKTLFGDVGFDIETEFSYQFSPPDVAAHKRDPDHHYFIVRRAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6B3</accession>
    <name>A0A5N6U6B3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6B3"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="35355" checksum="D40BC97985DB11A3" modified="2020-04-22" version="1">MSIQSIAKIFNFNFINDSQKLATMRKQTHAVFLIPEILEMILLSTDTQTLLTSQRVCGLWRGLIKKSPHIQKALFLKPISEKAKKAQGGEQITNPLLSEIVWPEFFCRSLNMRYRPAHESHHFPKIDPAREKAFLRPEASWRKMLLHQPPTERPSFHKRLEFVSQIVELNTPWIPGHGPIDLSDLEAAIDRGLLIPSTYTLLFWAQYDQQRREYTTVPNLKHIEAPINRSLRKSDLIIYMMTHSRDLVILPSPPRSETEGATQRHQAEESDFEILYRSEFRDLVKSSSDNGQIKILGSWDLHRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6F1</accession>
    <name>A0A5N6U6F1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6F1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="735" mass="81818" checksum="600D8D3223AA07CC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6W3</accession>
    <name>A0A5N6U6W3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_136043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6W3"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024804230" evidence="2">
        <location>
            <begin position="20"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="89"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="390"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="533" mass="57116" checksum="40388B7783DEF288" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7J4</accession>
    <name>A0A5N6U7J4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <location>
            <begin position="386"/>
            <end position="404"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="585" mass="65477" checksum="10B5FE971235529E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="12115" checksum="36D2D719D56C2606" modified="2020-04-22" version="1" fragment="single">MPLVKIDLIRGARSRDEVKCLADVVQEAMRRYFNAPDRDRYQIITQHEDYELICEDTNLGFTWSGKLVIIQIFQQGRSQEQKVAAYKALFENLSSKCSVSEGDLI</sequence>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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</entry>
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            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8A2</accession>
    <name>A0A5N6U8A2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
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    <organism evidence="1 2">
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8A2"/>
    <dbReference type="OrthoDB" id="3446576at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33062" checksum="5EC3E56BE3ED1328" modified="2020-04-22" version="1">MSSLPNTVLAAVTTNGSDSYLYYQSGREIREAHSETGSSWTAVASTVATNASGGGSALTAYYVDEDADFDKQATIHVVYLDSSTKVVDKVKVLSKGTWEDGQVTGIETNPATNSRLTGASFNGTTGWNPKGSQWVYYNTPSGNELQITEIRRTPNSPWYTETVLPEETQALPGTDLATSIVNKRIDLYYQDHDGNVDHWFQDGKWNDDGILVPASNVQISTPLATVNADNKHVFYVDKSSPSKIQDRVDGKDIEVANYYPGTHLDALVVDNKVTLFYKSLNPAGAIATKVYDGSSWADGATVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8B9</accession>
    <name>A0A5N6U8B9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_170991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8B9"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055826">
        <property type="entry name" value="DUF7402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF23">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLPHOSPHATIDYLINOSITOL DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24135">
        <property type="entry name" value="DUF7402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025014923" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7402" evidence="4">
        <location>
            <begin position="373"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="55232" checksum="3A8BBE0206F5563A" modified="2020-04-22" version="1">MKVSPLLGGLALLSRIPISTAQTLNIVAHEDDDLLFMSPDVLHEVQSGRAVRTVFLTAGDAGDISTGYWEQRQAGSQAAYAQMAAVDDAWIQTDAGIAGKNIPLFTLRDKPEISLAFLQLPDGNLNGDGFSTTGQVSLQKLWKREINRIQAVNGSSSYTYEELLNTLVDFMHDFQPDRVNTLDYVNQYGDGDHSDHHTAAYFVQIASGRCAVTHSLTGYTGYPIQKMDEDVFGDDLKAKQNVFFTYAAHDSKVCHDLEGCGDGNEAQWLKRQYTVTDEPVANAHEIGDRRVVGLMETVVLDGTKSRAPHGAALTYQWTQIEGATVKLSNSSVPQPSFATMPAPDVVVFQLVVSAGGRSSTPARVTMITTGLKNVARDVMVTASSHNVNTGQTVDKALDGRIDGYPGNTTGEWATDGGKAGTTFTLIWANPQLISEVFLYDRPNLNDQVTGGSLEFDGGSKFDFGALDNYGNLNRISFGRRVASNLTLTITSVSPSTDNVGLAEIEVYGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8P2</accession>
    <name>A0A5N6U8P2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_146789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8P2"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="185" mass="20494" checksum="E3B371C3AC16A968" modified="2020-04-22" version="1">MPPKKRTPAPKKPRQSKLAKENDISNDEEAEIKEVFHLFSTSHPEYKSEKEGVIAREDVRKALVALGLAPSSPAQFQDILSAVDPTETGYVAYESFLAVAAAKLRSRDDDAMEAEVDAAYQLFTRNADGPIKLQHLRRIARELKEDGLGDDLLRDMILEANGGASLESGVTLEQFHDVMRRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U901</accession>
    <name>A0A5N6U901_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_171808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024912976" evidence="3">
        <location>
            <begin position="25"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="38096" checksum="988147DB43F43BFB" modified="2020-04-22" version="1">MHTIIAFILKIVGLAIDLFQQLFARRVGWITIDRKSGKITREQQPLLKKLKLLVLFNPITEWVDRTHLLRLWTHERSLRAGAVETRPESHEEIKSFIKFYNINMAHFHPSDPEAYSTFGDFFIRKHAPGARPIYKKDDPSMATIVSDSRVVVYPTVEATRKLWIKGDKFTIANLIQDPFRAKSWVDGAVASFRLSPQDYHRYHSPVEGTVRWIKVIPGVYYQVDPVALQSSVNVLTENARCCLGIKSEEFGMVLFVAIGATDVGTVEIHDHVTAGYHIKKGEEVGLFQYGGSSIIVAFEKGHIQFDEDLERSSHQKIMVNVEVGQSMGRSMKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U907</accession>
    <name>A0A5N6U907_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_126215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="20626" checksum="37709D156B05BA88" modified="2020-04-22" version="1">MKSQTSPNIPNGSSLPRNPRYPSSVLVETITHLVPEDGIYQDPRNDRLMSIGLSYGANFAYTHRRCYFVVDYGTSETDDVPVTCYEWTGQAFKRVQEELKKAPSSTFHTQKKEKRPVREKIRFKLRGAARINDMDVDWLEHHREDMEWLRGKLRPRFWDQLLVQIEEVWYWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9E6</accession>
    <name>A0A5N6U9E6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase c assembly-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_31</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="COX14"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8155222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="251" mass="27408" checksum="D5BC0E65CDDB18D0" modified="2020-04-22" version="1">MSRSAADATRFTATGPYATSKASSYKLPGFMAPQNQGGSGNGSGNGGKPETPKEKVERLRAQARAARMARSSNGVDAMIDVGRRFANKAHKAMVYTLIAASGICGALTVYSMVSLTLYNRRQRALWIEKELRTLQDAKTAYAGGTATTEQLELLKNERIGEIYEQKKEEEKAQRPWSKMKTYVFGGLKTDEVQPETADKPGVLEALNAKVAEEKAVRPSPVQPGQLDKLAENVEDAAKQTGRSWTSWFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9Q3</accession>
    <name>A0A5N6U9Q3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_126014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9Q3"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="38"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="216"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8155328.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="68924" checksum="D35EAC71C05FB242" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
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    </dbReference>
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        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="323"/>
        </location>
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            <end position="734"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="118"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="722"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        </location>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lyhne E.K."/>
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                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="527" mass="60199" checksum="6079F13DA41C96E9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF29</accession>
    <name>A0A5N6TF29_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CENPA homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Histone H3-like centromeric protein CSE4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_79899</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742407">
        <property type="protein sequence ID" value="KAE8144973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF29"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8144973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="178" mass="19456" checksum="820367C843A6F32E" modified="2020-04-22" version="1">MPPKTGQGRKITAAPRAKAESAGKESAAGTSSVAATNSQSARGPRKSTGVTKGKRPARASDVQPGDPTPRGRQRRHRPGTMALKEIRKYQRSYDLLIRKLPFARLVREVALELLPSEVGAQLRWQSQAIMALQEAAEAFLVHLFEDTNLCALHAKRVTIMQKDIQLARRIRGAWGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFI7</accession>
    <name>A0A5N6TFI7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_165375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742386">
        <property type="protein sequence ID" value="KAE8145102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFI7"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
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</entry>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
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                <person name="Andersen M.R."/>
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            <strain evidence="3 4">IBT 18842</strain>
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</entry>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Grigoriev I.V."/>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="LaButti K."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF25">
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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</entry>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kildgaard S."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
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                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742320">
        <property type="protein sequence ID" value="KAE8145701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THX6"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057559">
        <property type="entry name" value="SAM_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23395">
        <property type="entry name" value="SAM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="577"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="3">
        <location>
            <begin position="775"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="867" mass="97180" checksum="D96F5AD9E183046B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI94</accession>
    <name>A0A5N6TI94_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_133452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742310">
        <property type="protein sequence ID" value="KAE8145819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI94"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="495" mass="54619" checksum="BC10EA8E7FD9EAA4" modified="2020-04-22" version="1">MKKPRLRIKQSQSTFAEGNARWTNLDLDPVPLHKRKWGPLSFIAYWISDAFNAATWQFASSIIAVGLSWRESLGIVALSFFIISFVISANGAVGAIYHVPYIPIVSRVVLALFWFAIQNVNGANAVRAMVGAIWPGFLAMPNRIPEREGITSNGMVAYLIYWVVQFPFLCLRPDRLRWLFVVKSVVVPVAWIAILVWAFVAEGGGGMFEQRVTVHGAQYSWVFSASMNSVLGNYATLSVNQESDFSRYSRVSPKWQLLYIPTLPLIFTFISFIGISASSAGQSRYGAPIPWDPIAHLSNWSSRACRFFGALSFALASLGVNISANSISAANDLTALFPRYISLRRGQVLCGVISWCLVPWRILASADSFLNFMSAYAVFLGPMAAIMLWDFWVVKRRKYDTLALYQAQNPVYWYTWGVNWRAVVAFLVGVGPNLPGLVHSVNAGVRVGVGLHPYQFGWLLGFVGTSVVYVVLSGGGAVMAEEVYGEGSVKDGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TID0</accession>
    <name>A0A5N6TID0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_163168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742287">
        <property type="protein sequence ID" value="KAE8146087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TID0"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="166" mass="18374" checksum="32709169BC7C87EB" modified="2020-04-22" version="1">MVVQPPNRKLDEFEDLVFHYSNGMNIPDDEERWEVDSAACNLRFESATQGPPARVSFLFKVIPRLCNAVGTLHGGCAATLIDILSTTILMGVSKPGHFSLGGVSRNLRVTYLRPVPKDTEARLICEVIHMGKRLVLMRAEICRADTGDVCVVGEHEKANTDPDIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TII8</accession>
    <name>A0A5N6TII8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_163070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742284">
        <property type="protein sequence ID" value="KAE8146137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TII8"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="11"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="448" mass="47460" checksum="A1E69DEEB8629B6B" modified="2020-04-22" version="1">MALAADQRRKILKVLMTSLLLDLISFTFILPLFPSLLSFYRAQDPSPTSLLNRIFHYLNAYKNVFAKPIDSRYDIVLLGGALGSLFSFLQAIAAPFIGRLSDKHGRRTALLCAMAGNTLSVALWVAATDFRTFLASRIVGGLSEGNVQLANAIATDISDVSQRGSTMALVGACFSIAFTCGPALGAALSNITTVAANPFATAAGVSLLLIVIETLYLYLCLPETHPRLTKLSHATAQSHGTTSAGTKSATVTPHKHTNNPAVLNAIHFLFLLPFSGMEFSLPFLTATFYAGHSASPSALNGRLLSMMGLIASLLQGTVVRRLPPVIIVRVGVVACTVSFFLLARVSTLTGLYASGGLLAITSATVVTGLNSLGSLEAQEGERGAVLGRLRSWGQVGRATGPLLFCSLFWWVGREIAYTTGGFVMLATCGAVFTMLKSPSVNPNPQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ30</accession>
    <name>A0A5N6TJ30_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_52142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742268">
        <property type="protein sequence ID" value="KAE8146363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ30"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="73" mass="8955" checksum="1D1A00E35D321872" modified="2020-04-22" version="1">MLYKNQMLRVEETPKARIPQFNLTCKVHRNICNDDEYAHCEDIMYMPVQICFYLLCFYTIVKEKSRKEMVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJA6</accession>
    <name>A0A5N6TJA6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_143686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="ML742261">
        <property type="protein sequence ID" value="KAE8146454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJA6"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8146454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="199" mass="22842" checksum="44B5B5F04FD39C4A" modified="2020-04-22" version="1">MSAKQTYLLLYNSLCTLLWLHILLTTITAFTSTSLTTTYTTLEPWTRWTQTLAAIEVLHAATGITRAPVFTTFTQAFGRCVQVWAINYAFPEVTASSWAYPSMLFAWSVADVVRYLYFVFLLARGSVPDVLKWMRYSLFFGLYPIGIASEWWMMFHAANVTTSALVMGIFYFFLALYVPGSPMMFSYMIKQRRKILARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK55</accession>
    <name>A0A5N6TK55_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_46997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742249">
        <property type="protein sequence ID" value="KAE8146650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK55"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="49443" checksum="5E866EDC3168E357" modified="2020-04-22" version="1">MADSQLAALEFFLQDHPEITYVPPFSPYYPAARKVWNVGRPDRPLAFLYPQSAEDVSAIVRYAKSAGIKFTIRAGGHNLEGRSIVENALTVDLRALRSVHVAADHQSATVGGGILASELGNELWKEGVATPLGAIPSVGYVGWATYGGYGSFSSNWGLGADQILGATLVNADGDIVKADEGLLKGLRGGGGVFGVIVDITIKVYPLKSLLAGAIMFNSQDVTNTFIDFNAEYEKLQDEGIPLELTVQQICFNAPPGRVYGVIFVWSGDDLEEGKRWNERISSLGPVVMNTVAVTTVPEYYAGNAGLVPNSAYGSTRTLNIRRTTPEVARAIGSSLAKMPSDPVTMLSVHQLRGPSAAPKENSVFGTREPHFMLEIIGCATAQEVREFSEEWAAHVVNAVQQTDSANILSTVYASLYPLGKGCQSSTLNKIFGSHTQEILALKDRYDPENVFSLTVPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK99</accession>
    <name>A0A5N6TK99_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_46019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742244">
        <property type="protein sequence ID" value="KAE8146745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK99"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="203" mass="22037" checksum="DC6C0917ED2A0D17" modified="2020-04-22" version="1">MNMDHMNHATSSASSSAATSMSSMSSMSSMSSMSMSMVFVNAHNTPLFSNQWTPSSSGAYAGTCIFLIVLSIIARLLSAFKAVMEQHWLDTHLNRRYVAVAGKSTEAGRIDADPDAKVASLVTAQGVEESVKVVRRTTREPLPWRFSVDLPRAFLFLVITGVSYLLMLAVMTMNIGYFCSVLAGAFLGELAVGRYVQANEHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKJ6</accession>
    <name>A0A5N6TKJ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKJ6"/>
    <dbReference type="OrthoDB" id="4359289at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="248" mass="28139" checksum="A478B7A3233877A9" modified="2020-04-22" version="1">MWTITEQSEAFIEKDGDVVYDHTKIILRQGENYFSATVKERVPKPEDLDITSLDMAHIPSEDFCPEFKHGITIAPDNLSNTYIKRPSLVAWDPSHPKTIGDLVRHEAEICEILKEHPHPNITKYLGCVVKDGRITGLCLVKYTSTLSEILAKSSAFERAMYCKDIERGVCHLHQLGLVHNDLNPTNIMMDGNIPIIIDFDSCRRTGEKLASKAGTFGWEIEGAEFATPENDLYSLAKIRELMLQPRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKS4</accession>
    <name>A0A5N6TKS4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_43321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="8"/>
    <dbReference type="EMBL" id="ML742234">
        <property type="protein sequence ID" value="KAE8146947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKS4"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000524">
        <property type="entry name" value="3-ketosteroid reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="429" mass="47005" checksum="015FEFC8BA18861B" modified="2020-04-22" version="1">MMSAHGTDPIQEQTFILVTGANSGLGFSICCRLADEFLSAHQQPHQSLTVIFTTRSSKKGHDTLTRLQHHLRTTAPTNTTRVTFVPENVDLGNLLSVRALSRRLNNTYPKLDAVVLNAGIGGWTALDWPAAIWGVLTDTVHQVTWPTYKIAPAGMLTDPQTTDQEPCLGSVFCANVFGHYMLAHNVMPLLRRSGGRVVWVSSLEATVKMFDIDDLQGLRTPAPYESSKALTDLLALTADLPSAAPWVRSFCSTPDTSEGEQNTQPNMYLSHPGVCGSGILPLSWPLFYAMLAAFYFARILGSPWHTVSTYMGACAPVWLALSSQAVLDSAESVYRQHGGGRVKWGSASTVVGKNSSASTETDGWGHGGVVGPAVVDDDRWRRRKRGAADLTAEERQEFEELGRKCWQGMEELRIQWDELLDVAERTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLB1</accession>
    <name>A0A5N6TLB1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Meiosis protein SPO22/ZIP4 like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_169373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742223">
        <property type="protein sequence ID" value="KAE8147142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLB1"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37818" checksum="2D40A9C8024B00FF" modified="2020-04-22" version="1">MTTSEWKEWRERVFIDLVWTLTDLHIHVQNGLQLIWKYIEVARSEGNTGLAEQFSLLVLEDPILSHEFSLTELNWLSFKSYNISLQVPKSSCPELVIRLIEISLELIVEAREEGEHGAKVPERFRIHIQGQIQASGKSDSHNEWCHKYRVVLSLDFESAIFLDQWERATRIIEESGSVLDGELASTFLDCIIRSGAVVRNIAQAIQKVIFAILTSQSTSLDCPAIQALLPRYLHTCFQLCLDASEYTLAEMNIDQALSLASHEQQEGIHYPSDELQWMATVAFNQAIDFYLASNDKDFRGWAEKAIRLTDFGEPECCALRKLLQEKIKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMU8</accession>
    <name>A0A5N6TMU8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_29110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMU8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="643" mass="71244" checksum="A494A27C53A174D1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN98</accession>
    <name>A0A5N6TN98_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_131798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742191">
        <property type="protein sequence ID" value="KAE8147767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN98"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845024" evidence="8">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="256" mass="28339" checksum="0AE50ADBAD76E9D4" modified="2020-04-22" version="1">MKFSILSTALVALASANPHHGQWRPAGADDFRGPCPMMNTLANHGFLPHDGRNLTRQAVIDGLGAGLNFNASLASLMFDMAIVVNPEPNATYFTLDQLNQHNVLEHDASLSRTDAYFGNNHIFNASIFATTKKYWTAPILDAKQLANSKLARQIESRAHNPTYTFTSSVEQFSLGEIAAPIIAFGDMQHGKVNRTLVEYFFEHERLPTELGWTRREEVVSIMDILGVTQMISNASSLITGEGRADRRRNLHFGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNC7</accession>
    <name>A0A5N6TNC7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_26356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNC7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="128" mass="14551" checksum="28F4076316D7A3C3" modified="2020-04-22" version="1">MQIFVKTLTGKTITLDVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKNICRKCYARLPPRATNCRKKKCGHTNQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNN4</accession>
    <name>A0A5N6TNN4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_142488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742194">
        <property type="protein sequence ID" value="KAE8147721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNN4"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="37654" checksum="1B24D05DE576F7AB" modified="2020-04-22" version="1">MTITTYPQGLGAQDPTLTNLSLSRLLARLEHNLLSPSADLKPLRRSEYQRMRVGANIAYARSTLQDLERSLPQIKPVDRRHEIQSDVTRDRQLLKRLQDALDQLNSEAEIRSSSEGGQQPEVAYEDDDESMDGEDLLDTPEEGSTSDEGRGLGVVEGDVEEEKKAAPEPTTSSPATATTTTTTASVDPIPTAAPTPSSTLRNRHNVSAESPATATGSSLHDNSTSVQPSPSTAKLQSTEEALDTQRREQEDLTNSLLSLATQLKSSSQAFQSSLESEKSVLNRTVEGLDRTTGNMDAAERRMGMLRRMTEGKGWWGRMMLYAWIFGLWIVAVLIVFVGPKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNQ4</accession>
    <name>A0A5N6TNQ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_142257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="ML742183">
        <property type="protein sequence ID" value="KAE8147945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNQ4"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="251"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="543"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="881" mass="99182" checksum="5E998B64EBE27482" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNS6</accession>
    <name>A0A5N6TNS6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742179">
        <property type="protein sequence ID" value="KAE8148012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNS6"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="374" mass="42321" checksum="F6E0DE2362C8D6A7" modified="2020-04-22" version="1">MASDSSKKPAVLIVGGLGFIGRHLALYLHENNLASEVRLVDKVLPQLAWLAPEFEEACSKDKFVQADASREQHFPRIFDRANGEQFDYVINCGGETRHSQPDDVYELRSHNLTVALARETARRGIRSFVECSTAHVYKSGSSPRKEDDKLQPWHKLAKWKMKASDEISKIPGLNYCLMRLPHVYGEYCSGYFAMGICLARAHLDMEKDLELLYSGDVKINTLYVRDAASALWKAAEWRATAPVDGSAPLAFNVVDHGDTRQQNIADALSNVFGLKCSFLGSLASQFAKLNLDDVIDDMNEECLQVWAELMEQKKIVRPGPISPFLERDVFKDQDMSIDGTLFEKTTGWKPSKERFNTDSVRDMVESYKRMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP27</accession>
    <name>A0A5N6TP27_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_22533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742174">
        <property type="protein sequence ID" value="KAE8148116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP27"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="226" mass="26047" checksum="A79C13726A0151C3" modified="2020-04-22" version="1">MSPMPDVISLSDIMRFRRELLVNPLLWTSRHLDAFGCSFQHIDNASTRDLDNGYEAPPQRNDKQESSAEGRTRTSDAEMLATSALPAVKYNILCRFLFHDGSVLNRRRKGPEFSFAGQPVHRPYYTVFYRRNEPNQFNPDVQPLIGYLDYLDVMGRRIRRYMPPTRPGNDHDAVGTRLFAKKLSRVTPAEWTEDPYFLCILLSIAQLQQRLSKDLSALSFFSNHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP67</accession>
    <name>A0A5N6TP67_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_131539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP67"/>
    <dbReference type="OrthoDB" id="3446576at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34526" checksum="5B5EDD411BED8874" modified="2020-04-22" version="1">MSSLDSTDLAGISTNDQDIYLFYQRSGNIVEAFTEQESSPPTESVNVASDAQNNGSPLTAYYVKEDQDHDKKSTIHLIYINKDRTLVEKVRVLPGEDWQDAPKPPGEAVDQSRICSDVSQIDRGPDSPPGSQWVYFTSQEGNKLPLTELRRNNKGNFHIERVLPEKSLSLPGTHLACVVTRERVDVYHQDHDKNIKLWRHETQKSSSWEDMGTVVEGRKVMVNTPLAAVNKDGMNHLIYADNQMKIMDMVEGKTIQVASRIYGNAGINAIPYKDRVVLFYKLIDPVGAIGTASYRDGKWKEEGPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP76</accession>
    <name>A0A5N6TP76_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_142040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742172">
        <property type="protein sequence ID" value="KAE8148152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP76"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
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            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148152.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="56529" checksum="1C7A41D3BD62D101" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPD7</accession>
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        <submittedName>
            <fullName evidence="8">Calpain-like protease palB/RIM13</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_159123</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00648">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="846" mass="94694" checksum="B063C9F5DB9A74FA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPF3</accession>
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        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_20772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742169">
        <property type="protein sequence ID" value="KAE8148233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000745">
        <property type="entry name" value="RNA polymerase II transcription elongation factor (Ctr9)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001586">
        <property type="entry name" value="RNA polymerase II transcription elongation factor (Ctr9), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1197" mass="135209" checksum="1169545778B42CED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPW1</accession>
    <name>A0A5N6TPW1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_131326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742165">
        <property type="protein sequence ID" value="KAE8148327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPW1"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="423" mass="46533" checksum="9F900045DCDDE867" modified="2020-04-22" version="1">MASTTSPPVSQQDDPLSNVAALPPIITDATVKRPPIRQRSSSYAKDRLSTHSNVSLASQNRSRPGSHVFPVFHSSLPYALVRDFAYPPTHPLHYGPLPPRASGISTPASEQRRLSDPPAPWDSSRGQWSTGPWSTDHSYGHQQLPAMSFGDGPPYSEDEDLHSPVFSAPRHRKNKSTGTDLNGGRKKSQSHGGFLGDADRGMFVSANADGSETYYVNDEDEADDGPGGEYVTYPANESRYSYVGPYGNYPGCDQDPEYDSEDDYAGDRYGDFQFAVGCPDEEMHGKAVALFDFTREHENELPLTEGQVIFVSYRHGQGWLVAEDPRTGESGLVPEEFVRLLRDIEGGLTSLNGGDIDTEFADDTHHHPDPTGYQTMTSTQEDHAGYVTNGGKKDHAQHGVEKFEHPTEQRQQEGNHVPIETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPW5</accession>
    <name>A0A5N6TPW5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_158351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742162">
        <property type="protein sequence ID" value="KAE8148393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPW5"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="279" mass="30555" checksum="CCC967F5DFAA65EF" modified="2020-04-22" version="1">MSSQPLQEQEQLTVMPASPARTTTLLQNLTSVISRVTAAGSKAADSKPVRLIAVSKLKPAADILSLHQPPAAHLHFGENYLQELQEKSKLLPPSIRWHFIGGLQSNKCVTLARDVRGLWAVESVDSEKKASLLNKGWGERSAELRATDADSQLRVFVQVNTSGEENKSGVEPVTEAVSLCRFIRDKCPLLKLQGVMTIGAIARSKATTPETENEDFVCLLQTRDRIVRELELQGEDARLELSMGMSEDFEGAIALGSDEVRVGTTIFGDRPPRDQAKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR58</accession>
    <name>A0A5N6TR58_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein subunit L20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR58"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="199" mass="22984" checksum="E926EDCD65FFDB65" modified="2020-04-22" version="1">MATYFTSIKRPLPSLPFLSPSSCEPIAWGARRHQSSYRRTKQRLRVKPDASFGTSSTNTYDHIIHNPPSSAPSVFQTPTKFLPVDDVRRTLRGSSTHVSTAEFSPVFETSGEKRYHLNASDVEEIRRLRLSDPMTWSRWKLAKRFDCSPMFIAMVCEASPQKKEIQKQVLEAVQSRWGAKRRMAREDRQLRKESWGRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR59</accession>
    <name>A0A5N6TR59_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ran exchange factor Prp20/Pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_130872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR59"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="87"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="387"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="506" mass="53900" checksum="D9C412E630AA869B" modified="2020-04-22" version="1">MTTKKTSTTKVSTKGHAAKLGATKPKDDARTKTASKGVRVAPSNKRKADAIEEPVHKPKKPRVAENRATKPKPKVVINQAPTTRLNVYVCGEGSSGELGLGPEKNAVDVKRPRLNPHLSADKVGVVQIAVGGMHCVALTHDNKLLTWGVNDQGALGRDTTWDGGYKDIEDNKSNADSDSDDELALNPHESTPTAIPSNAFPEGVVFVEVAAGDSSSFALTDDGLVYGWGTFRSNDGILGFDATHKVQPTPTLITTLKKVRHLACGDNHVLALNDKGAVFSWGSGQQNQLGRRIIERNRLNGLQPREFGLPKNIVHIACGAFHSFAIHQSGKVFAWGLNSFGETGIPDNAGEDEAAIVHPTIVDSLSGKNVTQICGGAHHSIAIANGEQCLVWGRLDGYQTGLKIDTIPEDAVIKDERGRSRILIEPTPVPGIKATAVAAGSDHSIAIDVDGRPWSWGFSATYQTGQGTSDDIEIATIVENTAVRGKKLNWAGAGGQFSVFTEQVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRI7</accession>
    <name>A0A5N6TRI7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_168249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRI7"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="228" mass="26161" checksum="46FAE2D383D36C42" modified="2020-04-22" version="1">MTSTLKPIRLYGGSFGPNPFKVSIILSELNLPVDPVPMDFGKLKTPAYEAINPNGRLPAIHDPNTGITLWESGAIIEYLIEIYDKENTISFAPGTPEAHQARQWHHFQASGQGPYYGQAVWFKRYHPERVQSAVDRYVGEIKRVSRVLDKWLETREWLVGNKLSYADLAFVSWQNGAKSLLSDEGYDENEFEHLTAWLERMNSRETVKELIDRQDRMIQEKMKSSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRN2</accession>
    <name>A0A5N6TRN2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_11188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRN2"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000478">
        <property type="entry name" value="Cell cycle protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="82"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="55807" checksum="0F382AEE6775F270" modified="2020-04-22" version="1">MCALHGAPAGIFELQKTGSLNHPHSATRPRFVVEDGATTDSDDASVTGHEEDDLHDEEDVDDSVKEDMKKLEDTFPGISERFRLVNRIGEGTFSTVYKAEDLLYDHYKNDWDTFQDHQYETWTSPPSKKRRIEGEGQLLPIKRRLSKFVALKKIYVTSSPFRIQNELELLHDLRGCRSVCPLITAFRYQDQVVAVLPFFPHTDFRIQYRTFMVADMRHYFRSLFTALHSVHKHNILHRDIKPTNFLYNPDIREGVLVDFGLAEREGSEYTGTCLCANPGFVRRSRFLQSYYTTHVSTSTMSAGYPKNDSRPSRRANRAGTRGFRAPEVLFKCTSQTTKIDMWSAGVILLTLLGRRFPFFNSADDVDAMIEMASIFGTRRMKTAAAMHGQVFETNIPTIGEKGYSWEKLVKWASCVEELTESEKQATRLLAGLMELDPYKRLSAKEALQHEFFTDPIEHDVEWGGHPEDSADSVEEEGGKDEEADEVAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSK6</accession>
    <name>A0A5N6TSK6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidic acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_156703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSK6"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF158">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G08970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="125"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="434" mass="48684" checksum="A9B01F4B62892836" modified="2020-04-22" version="1">MDRIPSKLPFTKRPLRPRIVISYIFDYVILVICIGGFFILDSIEPYHQHFSLENRTLWYPYATHERVPMPMALCISGVAPLLIIAVYTLFVDGLFSHSKPVDPKTGKRKLTGPYRFKDRLWEFNCGFLGLLLSQGLAFVITQCLKTACGKPRPDLIDRCQPRPGSVDAFPGLSNYTICTGDKTILKDGFRSWPSGHSSSSFAGLFYLTLWLCGKLHFMDNRGEVWKALLIMTPCLAATLVAVSRIMDARHHPFDVITGSLLGIVCAIISYRQYFPSLAEPWKKGRAYSIRTWGKDPTEVPHCAPVTESTAALRNPEQERLNSSSAPDAADPTQLRASRYMPPANNPFATVHDDDGNWSSSSEDVANGYEMQQGYTRTQNPAMGGGQLPRYETDTAYHSQLQRSESEYSAARPPTASTIRPTNERELTDMPARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSQ9</accession>
    <name>A0A5N6TSQ9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSQ9"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="116"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="505" mass="55605" checksum="DB41656A8DEC6BCF" modified="2020-04-22" version="1">MFDGLMGKSLRNSINMIGQEMTKRSPLNFSGHFGDLLDPQTSSISFIPSRFLWFLSCLSFNCRAVNMSTISRTANLLFRTSRASLLRPRAVNPVQHVFLKDRVAARGMATAFERSKPHVNIGTIGHVDHGKTTLTAAITKHQASKGLATFLEYGAIDKAPEERKRGITISTAHIEFSTNDRHYAHVDCPGHADYIKNMITGAANMDGAIVVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKVDAVEDPEMLELVELEMRELLSSYGFEGEETPIIFGSALCALESRRPEIGTERIDELMNAVDTWIPTPQRDLDKPFLMSVEEVFSIAGRGTVASGRVERGILKKDSEVEIIGGGFTGMKTKVTDIETFKKSCSESRAGDNSGLLLRGIRREDVRRGMVIAAPASTKAHDKFLVSMYVLTEAEGGRRTGFGTNYRPQVFVRTADEAADLSFPDNDESRRVSPGDNVEMVLKTHRPIAAEAGQRFNIREGGRTVATGLVTRVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSS4</accession>
    <name>A0A5N6TSS4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSS4"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="118" mass="13339" checksum="EA5BC6972EAE63F0" modified="2020-04-22" version="1">MNENQAVKYLESLIGQTVRVHATDTRIFVGSFKCTDSARNIILANTYEYRFPSSSAVQDAATKAENQDSQTTTESQNFKVNMTSRFIGLVVVPGQHIMKIELEETPQQSRVRETLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TST7</accession>
    <name>A0A5N6TST7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_3160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TST7"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="433"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
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        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="818" mass="90009" checksum="977415063186E775" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT39</accession>
    <name>A0A5N6TT39_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_140724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT39"/>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="242" mass="27905" checksum="2E98564774CB1363" modified="2020-04-22" version="1">MAHMCLWCMRAFESREALHLHNENTGRHRLWCGRCEEFFASDDDKAYHINHSSNHFICPRCFADLTSYQALNDHLRKKHHLCFFCELYSSSAEEALEHAVDLHYYCPDCNKYYSDRGALVRHRASHEQTAVQCPRCHHDFRFFSGMVHHLEHNICSVDTEEVRVYELAVRSNVSARCVLPESQGALERYYCESCGRKFMHLSGLCQHAENTAGCMQLAVGNGVLVLLRKVLETALEGTRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT91</accession>
    <name>A0A5N6TT91_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742128">
        <property type="protein sequence ID" value="KAE8149281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT91"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="137"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="506" mass="54785" checksum="2C29EB8A07A39417" modified="2020-04-22" version="1">MTSFSNGDARPSLSHADQLDSQHQLLQHDSTLTVAQSVSLTIGGDSLLVVDERPRSTDQRACCGLIAKSTKTTHAIGLYNILDADLSSTGLTITYAEPVPKDSVTVTALEYPIAEEEKAHAQAWVSQLSMLAYGEAQPYKRLKVLINPFGGKGTASKIYHKHAAPVFAAARCKVDVQETTHQGHATEIVEEIDIDAYDAIICCSGDGLPYEVFNGLAKKPNAGEALAKIAVAMIPCGSGNAMAWNLCGTGDASVAALTIVKGLRTPMDLVSLTQGKNRMLSFLSQSFGVIAESDLGTDNIRWMGAHRFTYGFLVRIMHRTVYPCDLAMKVELDDKQVIKEHYNTYAHNPAPTRSPEETAGQSKGLPQLKYGTVLDELPKDWEVIPGEVMGNFYAGKMAIVSKDTNFFPGSVPNDGLMDVVTIDGTIPRTTSLKMMTAIPEGGFFDMPDVNIRKASAYRLIPRQKEGYISVDGESIPFEAFQAEVHKGLGTVLSKSGHLYEAEGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTF6</accession>
    <name>A0A5N6TTF6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_140571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742116">
        <property type="protein sequence ID" value="KAE8149655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTF6"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="36606" checksum="3689B77072628411" modified="2020-04-22" version="1">MARRASKRSGAQSLGPTHQLLLAIARVTNSANAAASVVGATRASLPTEAQLTYAQVIVSLAQLQSAVSELSKAYINHANTVLNRGETVEIGSIANITNALYESGLLGTIGGARATSPGAKSDTGDKKKRKRAPPDPNAPKRALTPFFLFMQHNRSKIAEELGSSAKPKDVSDEGTRRWADMPEEEKEYWKKTYADNLAIYKEKMKAYKAGLPYSDDVQAANQLQQEADRAEATAAEESEEEEEEEQEQEQEESSPEPVKEPTPPRTKRRRSETNKAAKEAASPAENKRASPEKKKTTRTPAKKAQEETPASTRKTTAQDKTRGKKKRKSEVAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTL5</accession>
    <name>A0A5N6TTL5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_155848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742115">
        <property type="protein sequence ID" value="KAE8149703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTL5"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="229"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="39625" checksum="68908394CE1B4CA9" modified="2020-04-22" version="1">MGDAPTSREHLLIAFYQDNSRLLEAREKFPQLDISTVKLEFGAPIPSELARKATYIVTLNNLPKVEDAENIKLIHFISAGLDHSLHNPIFKETAIPLTSSSGIHGPPIAEWTVMNWLVASRKYAHAYENQKEHQWRKDVDKHFESIHDQVGKKVGILGYGSIGRQIGRVAHALGMTVHAYTASPRPTPSSRRDTGFIVPGTGDAEGTIPVSWHHGTDKESIHKFLSLGFDHLVIALPLTPQTTRFIGAEEFALLSANALPKHPKPYITNISRGKVLDQDALIASLESGELGGAALDVTDPEPLPADHPLWDAPNVQISPHVSSLGVEYFSRTLDIFKENLGRLQKGENLINEFQRGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTS7</accession>
    <name>A0A5N6TTS7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec61beta family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_155941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742116">
        <property type="protein sequence ID" value="KAE8149684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTS7"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="128" mass="12727" checksum="8A7FAC7D11AB6863" modified="2020-04-22" version="1">MASPRAASPLTSGAESGPDAKASGSGAGAAGSVSSVARTSSPTPPGGPRAALRRRAAADHKESLRNARPSSTRAAGAGGSSGTMLKLYTDESPGLRVDPVVVLVLSLGFIFSVVGLHVIAKITRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU04</accession>
    <name>A0A5N6TU04_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_120907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU04"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="191" mass="22158" checksum="C83EE120489CAD97" modified="2020-04-22" version="1">MALGFMPSYAHLIKHRSDFALAHAYHLIPEQVKWTEWCQFIQYFRDLDDTQVAKRYHYGQMRLSRLNWAVRLFQPPSATTVWFYDIPNWSIGTYVQRIAKPLIFGFASISLALASMQVLVSITAEDLGWGAIGIRAMCRAIWVFSIAVLFLSGIVWLLMFVIPMAVLVWQVSWGFKHRDKQHTARMDTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUB9</accession>
    <name>A0A5N6TUB9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUB9"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025051118" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="496" mass="54699" checksum="6862956C4369EC2D" modified="2020-04-22" version="1">MKASTTWRAILVASIAANPPVAAADICSQLEAEGIETEKRLTIDYHKTLTDYWSTACGDLRPTCIATPSSALKMSQIVKELHDVDTLFAVKSGGHMPNNGFASIQDGLLISTQNLNHVIYNAQDQTATIGPGLSWEEAQKGLEGTGRTIVGGRLGGVGVGGYMLGGGLSFLSSQYGWAANNVVDFEVVLANGTIVNANAKENTDLFASLKGGGNNLGIVTSYTLQTHPQDHKVWGGNYVFTSDKTPQILEALRDFTENYPDEKAAIIVTAERGALLDLWIMFLFYDGPEPPQGVFDRFKAIGPMDSTKTWDSYYDLLKHNDFFILKGQRYTIATETTPLPNKTVGAEVMQTYYDHWLNVTKTVFSVPNMLGSIAFQPMPRTIAQKAKDRGGDLLNFPTDQDYIIIELDFSYAFAASDGKIDAANKNLFNGFNTIISRYIKEGVLPDVYRPLFMNDANYAQDYWGRLGSTAQARQTRQKYDPDRFFQKRTSGGWRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV64</accession>
    <name>A0A5N6TV64_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_155318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV64"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="27177" checksum="D248A11689806C05" modified="2020-04-22" version="1">MFSRTALARAFALPFEQSARPLTTRFGVCLRQASTTTTSQSHPEQPTEPLSATPRAQTSAPSQQPPTSTPSSTPQIPASKLPVAPAFTSPVEVTKSLLENLPYLTGQKPHYITAHLHDKPYLLTEGDHLRLPFLMPNVKPGDVLRFNRASLLGSREFTLKGTPYVDERLYECRLRVMGVDSEPLRVKEKTKRRRRHVQRVTSKHRYTLLRVMDIKIKTAEELLQEGAVVVEDGKGVSEVEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV69</accession>
    <name>A0A5N6TV69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_113591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV69"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="26124" checksum="BA55DA896CE5F390" modified="2020-04-22" version="1">MQPSQDNPGNANDRPGTPPRPPYSPVTPVFAHLAPVQNIGAPSHPIVPPSPGNAILEEGAPVSPTTRAVFAPEPTLVPISESENPDAIALRSTISILQLQKQQSLRDIRTLERLKKAAAADPEGFARELAAGNLTARDPGGLVNFTHDEDTEGRGGRTTLPTPQNVVRMPPINWSKYQVVGEPLDRMHEDQRRRPSLGEPRREESTQRAQEHILASPYRPLVDKLESPDKVRGVKNKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVP7</accession>
    <name>A0A5N6TVP7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_154275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVP7"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40265" checksum="E0D232F48878AFD6" modified="2020-04-22" version="1">MDQDTENKVLVIKNIDSGYLVAGEQVTLETVQYDATQDIAENELMLQLLYATYDLFKRDLTGPNDSVDVRQPKPVETMSIAKVLNSNNENFQAGDMVIGRLPVQQYVILSAESASGVKLLDNPGEIEDVRLFLSVLGIPGISAFSSLYEIGRPKKGETILIANASDEIGQIAGQIAKLEGLNVFGSVDSDEKLDFITTQLGFDGGFNYVKESPYDALSRFAPNGLDIYYDNLSWMSRLSIGGLDTHYDLLGSKHLNAAFGSMRRYGRIMFYGTIAEQTVLDPIIGMFLHNTVLKRLTIRGFTLCDPSFGKKWGGLHQERMQQWIKEGKLSIPTYEIQGIEHAAKAFVEAFYSTQTGHTILAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW54</accession>
    <name>A0A5N6TW54_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_154228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW54"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="170" mass="18582" checksum="9EBE66C90D258309" modified="2020-04-22" version="1">MSLVNLAHVCSHLNNASRARLGLTSIPNSNLHLRLCLALQNSGYISSVVRGGPTPPPQHNILGVPAANDEIEGVQSLTQSNVASRRLWLGLKYWQSEPVLGKLSMVSKPKRRINIDVTGLRRVIRGEKSGYVEGLRSPGESLYLSTDRGILEARECVEKQVGGLVLCRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWI7</accession>
    <name>A0A5N6TWI7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gaa1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_172171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWI7"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:attachment of GPI anchor to protein"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="767"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="889"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
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        </location>
    </feature>
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        <location>
            <begin position="670"/>
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        </location>
    </feature>
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        <location>
            <begin position="682"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="890" mass="98975" checksum="4C85B3E33F91AAEC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWU5</accession>
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        <submittedName>
            <fullName evidence="5">Pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">BDV25DRAFT_153833</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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            <begin position="133"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111872" checksum="FCC652E9DFBCEF97" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWW0</accession>
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        <recommendedName>
            <fullName evidence="8">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BDV25DRAFT_139564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31309" checksum="A67BEDAF19F4FA42" modified="2020-04-22" version="1">MTRQKTVLITGCTPGSIGYALVREFQSRDYHVIATVRNTDLVPELTSQGMTALALDITDSMSIAQCREQVGRITENKLDILINNAGRGLVTPAVDTDLADARAVYETNLFGVIATINAFIDILIPAKGLIVNISSASALIPYVFGSVYSSSKAALAAYSRTLREELKPVGVRVQVVMAGTVRSNMGKAVKGELAEGSLYEPVRHLYLARRGYSQKEGSRPMETGEFARRVVDCAVRDEVGGFWRVVGFGRQDWVFEGGMARLVGWGSWVGEWVVVLVCGVVFGLGGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX07</accession>
    <name>A0A5N6TX07_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_139348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="453"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1585" mass="175311" checksum="A9CCDF2F49645A28" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX20</accession>
    <name>A0A5N6TX20_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_105005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX20"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="571" mass="63401" checksum="3D7376C7DC20BB7B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX26</accession>
    <name>A0A5N6TX26_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPI biosynthesis protein family Pig-F-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_139477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX26"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="270" mass="28687" checksum="291A27AC5B27B5BD" modified="2020-04-22" version="1">MSTSTQTPTNPAPPAAQKITPPTQILNTTIAKLYSTIHPLVLLILVTVRFDALVQDPISELLNDLPFLVGLQLLFVVLCLPPAGADEKHDPVHKSKAGIRRRVKTDAVGGVSGIVAGFIPGVLSLILTTLLATPVLTLLLVLFGAPATTHHAQTVLAGAHMAVLASPPLIYVHGVDGSVWREVWGANRPGDVVWGGALGTCVGAWFGAVPVPLDWDRPWQAFPITVLVGAYIGYAVGVWLGGSVLFGRRLKIEEDEDLDLDSEVEGKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX88</accession>
    <name>A0A5N6TX88_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_129181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX88"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="41773" checksum="37753C01D4483B78" modified="2020-04-22" version="1">MQPSKDRPHSPKRLRSTCDRCTTLKVRCDKKKPYCERCESTQHRCVYGPYRWKGRQPATHDFASKTYGHPTELTKSAKVSKPSPQHTASTAQMSTGLWPVAHPNILSNYALFSEMKALPVELHDEIDDFPAGLGGELGQSISPLPLGMESSSGPDRTPSQETSNYMSSLPGSDTLSVLETSPSLSYMSSPESRTPDVACYCATLAFSTLHDMHHAEFAFRMENNSGLLSRDHIFKMNRTAVQNLNQLLSQHCIVCLSDHSVLFLITAIGSKVLSWYQILFSRISRHPPDARLMHPLGTGSVAPVYFGDLELDGVTEQRITAQFLLCELQSLSKVFELNGEESMGTVLSTTCSFLFSTLNNLASTIDLFCVSKPSVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXK0</accession>
    <name>A0A5N6TXK0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4 12">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_153219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="12">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXK0"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11 12" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="13">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8151116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="154" mass="15805" checksum="94A78A0A127CA573" modified="2020-04-22" version="1">MVKAVAVLRGDSKISGTVTFEQADANTPTTVSWNITGHDANAERAFHVHQFGDNTNGCTSAGPHFNPFGKGHGAPEDEDRHVGDLGNFKTDAEGNAVGSKQDSLVKLIGAESVLGRTLVVHAGTDDLGRGGNEESKKTGNAGARPACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXQ0</accession>
    <name>A0A5N6TXQ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXQ0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="27408" checksum="57C1C3D7F946FDC8" modified="2020-04-22" version="1">MTQNIVLVTGANQGLGFAIIQVAALRHPTNTYILCSRDLNAGNQAIQKLRDLGVTARIDLVQLEVTNDDQITAAVHHVTTTYGKLDVLINNAGILHQPNSSLRTSYNNLLNVNLTSTAMVSIAFTPLLHKSPDPKVINISSGLGSIQNSLTKKMGRTVPYGASKIGLNGLTVHMQVAENDRVEVGEESEKPRIRYFVCAPGALKTAFSNFWPLGRLPEDGAEVVVRLLGDDGGVYGGGSFWEFVEGEMRIVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXT2</accession>
    <name>A0A5N6TXT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXT2"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF307">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="431" mass="47640" checksum="F3522D5AFF9244A1" modified="2020-04-22" version="1">MTTQAKTPFQVVVVGAGIGGMAAALTLGLRGHHVMVLESASKLQDVGAGIQVSPNMLRIFDRWGLSPSIHARDVALENIHVRRWQDGSLLGTMPVNKLYGQQVVIHRADLHNALVEKALVLPNVDLRVNSTVIDVQFSPASVTLSNGTIVRGDIVIAADGVKSTIRGHLLGQESNLKAIPTGDAAYRIILPRSVMEKDPELRELVDEPQATRWLGPDRHIIAYPVRKHELFNVVLLHPDRHGLEESWTTKGSKQAMVDNYRGWDSRVTKLIDLVAEDEVLEWKLCLHPPLKTWYKGSVSLIGDACHPMLPYVAQGAAQAVEDAAALGVLLSVISSKHEIPLALQAYENSRKQRAETVQQSGSANRITLHLPDGPEQRARDEQFRLSMQGGANPDRWSDRETQTFLWGWDAEKAALEAWTQIEGDMSPRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYV3</accession>
    <name>A0A5N6TYV3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_171336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYV3"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025032295" evidence="1">
        <location>
            <begin position="29"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="114"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="451"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="598" mass="64910" checksum="035CDEBD4B4B5D35" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ75</accession>
    <name>A0A5N6TZ75_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ75"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="38853" checksum="1D5DA74349405B82" modified="2020-04-22" version="1">MAHLGIVPQFLARVTPMETKLAALNEATAAYTAAGYTGMIDMAMSDAEWNVLKTFRDGYGEDFPFHIAAHWIVPYSDDREQVFATVDLAIARHREYSPSISPRFCIVGIKLMCDGVVDGCTAALTEPYNGSENPVDPIWPVDLLQEVVKKADAAGLQIAIHAIGDRAIKDAIDALSQAQPGHRHRIEHLELASPTDAKRLGELGITASVQPVHSDPALFRAWPELIGKHRCARAFAYREFLDGGAPMALGTDSPTAAHAALPNLYNATTRRSAIEPQCTDVVNAHFGLPLAAAITAASTGAAYSRKAESWTGCLRAGYQADFVILNMDWEAESLLKARVYQTWAGGRKTFDSSSGRGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZG6</accession>
    <name>A0A5N6TZG6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_87953</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000051">
        <property type="entry name" value="Nonribosomal peptide synthetase sidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000055">
        <property type="entry name" value="Nonribosomal peptide synthetase sidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000027">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000038">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000014">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000015">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000056">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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    <accession>A0A5N6U092</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21195" checksum="C80F455052E9D872" modified="2020-04-22" version="1">MTTLRTHDEFLLDHEEVDEPRKKNKVLHSATRICYDWMVISGNCHYARDRAVFASYRPVELRLKNNVFNPHDELLVAGIGTVHLTVCRSPQDPTPHIITLEDVLHIPEAVCNGFNPLLFGSSMSCNADHWEGADRAGQPVWFSVPFAGHTRLVLAGNPTGESDLIEGRYYTLSLYITPEEKQFLHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0E5</accession>
    <name>A0A5N6U0E5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_151724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0E5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="76" mass="8342" checksum="DAB040139D1FBB13" modified="2020-04-22" version="1" fragment="single">MVVFIMSELTMKAASPDTLGASRAACPVIQPFQNNTFSTLNHYPTTHNPYTSMVSSGISDFTSPRSTPLRTEQETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0G9</accession>
    <name>A0A5N6U0G9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_151595</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0G9"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024808832" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8152117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="193" mass="18775" checksum="E26B3F3281C49670" modified="2020-04-22" version="1">MKLQYIPLTLAACLATVAAQGMDGLPDCAKDCATGSIPKKCQNIDVACICGDKNFINDIACCVSTKCSSEQQEAVIKFANQICSGAGVNDLPKSATCASGSSSAAQTSSGSSASTKSSSATTTGTNASASTTDMSGSSDSAAKPTSSDSSSSSKTATSSASSAATSSAGASLVQGNDMNLFAAVGAAAFALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0K9</accession>
    <name>A0A5N6U0K9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_170861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0K9"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="533" mass="58433" checksum="BDE80EA8FF7588E6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1N5</accession>
    <name>A0A5N6U1N5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arabinosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1N5"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="GH43_Bt3655-like"/>
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    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
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    </dbReference>
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        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025068270" description="Arabinosidase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36020" checksum="3D0DDBDE52A75011" modified="2020-04-22" version="1">MKLAQIISTSLALSIPALASPVKRDEKAGYLSVYWTTEDESVFFALSENDDPLDFSPVNGGRAVATPTIGTGAVRDTSIIAGQGESEGKYWIIGTDLNIGKTTWDNAVRNGSRAIYVWESNDLVNWDDTSLVTVEDTTAGMVWAPDAIWDPEEEQYLVHWASKLYSETDAAHKQDPQTPNILRYAHTKDFKTFTQPQTYLQQPTDIIDLSFLPLNETTFLRSYRDDSGGLPVEISTTGLRGEWTFLSKPPDSGSFEGPYFFRDNLDPSKGYFLADLVGSRPGVQAWVSSGDVAGGVFVKDTDHELGFMRHNSVLAVTGEQVGVLRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1W5</accession>
    <name>A0A5N6U1W5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1W5"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="287" mass="31454" checksum="078A0AD1E40449DE" modified="2020-04-22" version="1">MGNDGGSIPTRRELVRSAARTPSTAQIKETQREQQSHAWSVCPLSHKPLARPIVSDSLGNLYNKDAVLRFLLPDEEIEGISSKGDCEEVLGGRVTGLKDVVELKFQVEEDGDEGRHKLDRREGWVCPVTGKKLGPGVKAVYIVPCGHVFSEEAVRFLKEEKCLQCGEGYEGGDVVGILPVKEEERAALGRRMQGLKERGLTHALKKVGKKRKKGVEEKGVEKRAKSGGNGIKNAATAMLTARVLEEEKEKKRRRVGMNENLDSLFSKSSGTSNGDFMTRGFTLPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1Y8</accession>
    <name>A0A5N6U1Y8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_150793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1Y8"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="37245" checksum="49E583BE6D550C69" modified="2020-04-22" version="1">MAPENMKQWSVKGKENGFDELAYTDAPVPKVGDNDVLVKFHAASLNYRDLIIPRGMYPFAINFPVVPGSDGAGEVVEVGPKVAGFKKGDKVITLFNQLHQYGPIDRQGAGSGLGGVIDGTLRQYGVFNENGLVKSPKNLTHLEASTLSCAALTSWNALYGLRPLQPGQTVLVQGTGGVSMFALQFAKAAGATVIATTSSSEKADKLKQLGADHTINYKSDPNWGETARKLTPNEAGVDYIIEVGGSGTLNQSFKCIKLEGIISIIGFLGGVDPKTQPSILDTLSNICTVRGVYVGSKELLNNMVRAIEANDIHPVVDAKVFTLDKAKEAYEYMWAQKHFGKLAIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2E6</accession>
    <name>A0A5N6U2E6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_57422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2E6"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="40413" checksum="F7EB1676C431958F" modified="2020-04-22" version="1">MAKSARRAGKAKASTTPSVSSSGTSTPSSQSGPLPPFTKAPASLQPFLEPLSPQEVYLVHIDTSPVDIKKQTFIAPVVLNVVITAILAFRAYTVRNVYPALLATLIGLSSSTTVDTSAMTWSEMGAMILRRTGTIMVDYFLVTIFLSWPIGFVRGPVMWRYKIGFKEREVVVRRSQPALTEGLERNRWIREDEAMRDKIVAAVTPDRLLKTGYLLVDADWNLDYKAMIKAHELVDRAKKHDDGIPLDEFRTAVIVNTDSDGWLIWHVEDEDTPEGRARSGQRDQILAFKDKLTAMGKEDLFFRWAELIQYESTRPGGFTLERQQSAMLQAKKMFEDENVDFARFWQEVGGLDGFVEQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2K2</accession>
    <name>A0A5N6U2K2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2K2"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="38103" checksum="7BE14E0BB7C2546B" modified="2020-04-22" version="1">MSFSVPSYIRDSYTMLCVCPTRLEFAAMEGALDEVHPNIATTGRDKNAYTLGQIGRHNIAVTVLPEAGHGMAGAVVMQALNDFKSIRFGFLVNVGGGIPSGDEYDIRLGDVVVATPLGTSSGVVPFARGRVQANGDFEQTKMINKPPQVLLEYVHRLQSKHLREGHKIDQIVRGMLGKFHIMRDERFENPGADQDLYFQNAYEHNGARGCATCDRTRLVARLPRAAAPLRVHYGKIGSSNTVINSAAIRQTLHQQLGVICVETEATGMMDEFPCLVICGVGDYLDSHKNSQWHPYAAATAAAYLKELLSVIPPSNNNGDRFLNSDVKKGLRHGEKELHTRTFHSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2L8</accession>
    <name>A0A5N6U2L8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spc98 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_57093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2L8"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="275"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="577"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="960"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112116" checksum="2E4B43BF3F6EDDA0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2V9</accession>
    <name>A0A5N6U2V9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_150347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2V9"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000639">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="400"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting protein 11 C-terminal" evidence="11">
        <location>
            <begin position="905"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="955" mass="106905" checksum="0E5FC9674C8D37B8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3B7</accession>
    <name>A0A5N6U3B7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_137465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3B7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
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    </feature>
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            <end position="481"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="510" mass="57358" checksum="FF5075EAA5F35796" modified="2020-04-22" version="1">MVTSKSNVVVEHQSSNSINDENSHSFQRQKWMIPSLSRYFGNTENLVVLKVDLLLLTWAFVSGLTKDMDQSATTQAYVSGMQKSLSLYGNELVEFTTFFSIGYAIAIVPSQLTQTKIRPSIWLPTCEIIWGALNLATFAAKNAKTVYTLRFFLGIFESTSWPGLASLLFNWYTPKELGTRLAIFGVSGYAGNMFLGILQAALYRNLDGVHGLHGWQWLFIVTGAITMAWGTLGLFVIPDSPSITRALWLTKRERKVAVDRMESYGIKTNELVDKRVVLRKLRALLRTPLTWLYIAAYLQYAWSQRCNSYFLLYLKGLKNSDGEQLYSTYKVNLIPLGGYAISIVSNVGLNFLSDKKQWRWQIAVGTALLQVLCCSVLSAWPNSRSTIMAFYFMTFATCGWGYSLLAWIGEILRKEPEVRSILVAMTVTLVCASPAPNVGHATIPLRIWRTSDSPRYPIGFPLAAAWAAGSILCMLGIEFYIKRHQEILEYGLSGGPEDEERDARDYLKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3F9</accession>
    <name>A0A5N6U3F9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complex I intermediate-associated protein 30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
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    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
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        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
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        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="232" mass="26220" checksum="BB64FDF212A158E7" modified="2020-04-22" version="1">MDAQLSHLPLFGGPKAWHASDWTSTDDRVRGGSSQSELTCSPSSLVAKFHGNLDITTLGGAGFASQRTKSEKRKWNLSSYDGIELNIAGGDGKLYTLNIKDEIAPKRPDGRQESALVWEYDFRADGAKKVYIKWDDLRPTYRGKEQGNVRPLDLKKVKQVSIMIRSFFGKQEGEFQLDIVSISAFRVKHYRDDPEDEDYEIIDDKMEDDVYSPDNPKRQGWLSWFGGCCGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3H9</accession>
    <name>A0A5N6U3H9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_169482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="604" mass="67179" checksum="FF97BCB1F7EB2F0A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U401</accession>
    <name>A0A5N6U401_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_127602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U401"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="89"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="341"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="481"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="581" mass="66738" checksum="52837B89C4F8A5D1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U446</accession>
    <name>A0A5N6U446_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U446"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="47888" checksum="D8F0C7D2BEC9316D" modified="2020-04-22" version="1">MSRYKVIEHTVRCQHVRGRPGATEPYRSGDLRMAVKQYVPESNQKPTPGDVTVIGAHGNGLTKELYEPLWDDLHEELRKKGRRIRSIWIADVVNQGRSGVLNEMILGDDPSLFDHARDLLFLVNQYQDEIPQPIVGIGHSMGGMHLAYLSLIHPDLFQALILIDPVIQRENIGRKYAVPATYRRDVWPSRQDAIARFRRNKVFENWDTRAFERYTECAFRDLPTELYPDARKHGDHPVTLTTTQAQESYMYMRPSYADGKIGLREGEWRVEMHPEDRDETYPFYSPTPARIFRRLEELKPSVLYMFGEHSPLSTPDLRQAKLEHTGMGVEGNGGRSVHRVKEVILSTGHLVPMEKVHDCAMVAARFTDTDLSRWEDEERKFLEKWDSIPRRQKISLGDRWKQNIGHHSRKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4W1</accession>
    <name>A0A5N6U4W1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4W1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="543" mass="62291" checksum="4269432A02764E53" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5G4</accession>
    <name>A0A5N6U5G4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_168907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5G4"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="241"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="45965" checksum="D08F6EC4F5435ECD" modified="2020-04-22" version="1">MSSSSTDVSREGTKVDASDAEMALNQKAPPPMTFPDGGAQAWMVALGAGGVLFCTFGYVNAFGIYQDYYITHQLSHRSASDISWIGSMQTFFLFAAGLVGGPLFDRYGGKVIWVPSFILVFSVMMTSLCKEYYQFFLAQGVLGGIGMGLSMAPALSSTAQYFQKKRAAAIGITVAGSSLGGVIFPIALQRMFNSHLGFPWGVRVVGFIMLAVLGFAVVAIRARLPPRKREFFKPSAFKSKKYVGTIITVFLLDLGLFTPFFYLPLYGEQHGMSSRMSFYLVSILNASSFFGRVIPGILADKFGTLNMLSFLSLVAGILTFCWDKMTNNATIIVFAVLYGFFSGGMISLTPAAIANVPENPQDIGTYMGMGTAVISIATLIGPPINGALINHYGGWLQVQIFSGVVILAGSVFGIVTKLLSGKGLLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5X5</accession>
    <name>A0A5N6U5X5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_148379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5X5"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="471" mass="51962" checksum="CB73204F11CDF32D" modified="2020-04-22" version="1">MAAYALSQAHRDQMEKSLVETDPEIAQIMEKEIQRQRESVVLIASENFTSHAVFNALGSPMSNKYSEGYPGARYYGGNQHIDAIELTCQARALKAFNLDPAKWGVNVQCLSGSPANLQVYQALMRPHDRLMGLDLPHGGHLSHGYQTPSKKISAISTYFETLPYRVNLETGIIDYDTLEANAELYRPKCLVAGTSAYCRLIDYERMRKIADKVGAYLIVDMAHISGLIAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVRSTDKKTGKDIMYDLEGPINFSVFPGHQGGPHNHTITALAVALKQVDTPEFKQYQEQVLKNAKAIEAEFKKIGHKLVADGTDSHMVLLDLRPKSLDGARVEAVLEQINIACNKNSIPGDKSALTPCGIRIGAPAMTTRGMGEEEFKRIANYIDKAINICKQVQGELPKEANKLKDFKAKVASETVPEILELRKEVAAWASTFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U699</accession>
    <name>A0A5N6U699_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U699"/>
    <dbReference type="OrthoDB" id="4220319at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="166" mass="18745" checksum="229DDFDED844446A" modified="2020-04-22" version="1">MWRGTIFPRSGWQTALKTRTVPLARRGVVTVQSKEKKDEALDFERQVLNPERTETCKTGTDDEVGHHKASYDPSMTAPEREYLADEEECRLEGRGHHPLFVSPANVEVSHLLNPMVGGAVHGADREGPSGMGWTRKNKKVHVKAVPGSEYEKYEKVLKGLRKVRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6E1</accession>
    <name>A0A5N6U6E1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_148449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6E1"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="663" mass="73991" checksum="3E9380A1622F66ED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6I2</accession>
    <name>A0A5N6U6I2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6I2"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="538" mass="60913" checksum="13C3A4B2D27C3AAB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6V5</accession>
    <name>A0A5N6U6V5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_116385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="278" mass="32143" checksum="37135E6C85806498" modified="2020-04-22" version="1">MADLNKEDAELLMGQDEHNNHSHDDSWRAPTPCKRCHQRWWFIGLLLVSILVNIILLVNLLRSPVASPDDPTTKFAGLQRTIEEPFVRMTKYSSENETLQDQLWHDINVDHGVVALSDEWAMQHGLRTAQRFPWDQSKGIYILHGYHNLHCLKIIHISISEYRNGQPQSRSWHHISHCMDALRRQVLCDADDTPRATERRAEVVSGVLQHRKCRSWEALEQFAKQHTACYKRPEKPDGVPIIERYKHCPPGSGYVVDDDYVPTDEFLVGLPEESLDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U7A9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7A9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="398"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="92483" checksum="984A36207CC3C837" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7V2</accession>
    <name>A0A5N6U7V2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_147598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7V2"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF4">
        <property type="entry name" value="HYPOTHETICAL AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="564" mass="62616" checksum="58541C54FC38B082" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U876</accession>
    <name>A0A5N6U876_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U876"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF55">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="563" mass="61067" checksum="E35FF7B2F8E907B0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8B6</accession>
    <name>A0A5N6U8B6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8B6"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852167" evidence="7">
        <location>
            <begin position="29"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="43447" checksum="FCBEEE4D0632D137" modified="2020-04-22" version="1">MAPRFSPSHRLGLALSAGLLLFSAFAIAKEALPVGEWSVGQIEDELQNCPLVESLNEQKRANSPQTTSLTARIFSVLFPGSPAVNAILATAYISGPPNFLLALCPPNIDPSSLSVMVAFAVGGLLGDTLFHLLPEIFLGEDSPDHVRFVMVEPNRNLLLGLGIMVGFFTFVAMDKTLRIVTGGEGHDHSHGHSHSSETGTTTGVSTSQPSADLKRRKPTSTPDPKDQEKEREQKEINPSVKLGGYLNLIADFTHNITDGLAMSSSFYASPTIGATTTVAVFFHEIPHEVGDFALLVQSGFSKRKAMAAQFVTAVGAFLGTFIGIAVQELGGSHGAEAGALAAGAGLWGTSLSWGDMLLPFTAGTFLYVGTVSVIPELLETGKDKGVEIKKTIVQFLAVAVGAGIMLLISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8C4</accession>
    <name>A0A5N6U8C4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UPF0160 domain protein MYG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8C4"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="362" mass="39591" checksum="4B8017FF1747B31F" modified="2020-04-22" version="1">MADETIAKKIKTSSPLIGTHSGHFHADEALAVYLLRQLPTYSASPLVRTRDPAQLATCHTVVDVGGEYEPANHRYDHHQRTFSTTFPNHNTKLSSAGLVYMHFGRAIIAQHTSLPEDHEDVALLYEKLYTDFIEAIDANDNGISAYDPAEISAASIQKRFKDGAITITSVVGDMNNPDPTCPPGEPQDEDSLFGRASTFIGNVFTRKLHHASTSWLPARATVGNAYKTRRDVHSSGRIVVLPQGGVPWKEHLYNFEKELGSKEANSAEEVYYVLYPESAAEGSKWRVQCVSVNESSFVSRKPLPESWRGVRDADLDGVMAAEAEQSGKPKIPAGAVFVHASGFIGGHQTKEGAFAMAVRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8P1</accession>
    <name>A0A5N6U8P1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8P1"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="508"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111134" checksum="213C077F78B4A970" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8R3</accession>
    <name>A0A5N6U8R3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_146831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8R3"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="258" mass="27189" checksum="2648C3C90D556198" modified="2020-04-22" version="1">MSGKLDKSLDEILVNRRQGVRRRNRRSTQSKTAAGAVGGVKKNTKAAKPAGKPAQGGHPASTESKIMVSGLPSDVNEANIKEYFTKSAGPVKRVMLTYNQNGTSRGIASIVFSKPDTAAKAAKDLNGLLVDGRPMKIEVVVDASHAPEVSAPKPLGERVVQNKPQPKPATATKAADNGRGRNRRNRRTGPKPNRPKPKTVEELDAEMVDYFSNENAGPAESNAPANGTAQQPANGGEDLGMAEISVSGVNPDHALASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9P1</accession>
    <name>A0A5N6U9P1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9P1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="235" mass="26826" checksum="725753E274FEEC7F" modified="2020-04-22" version="1">MLRLHFQALRGNAIGRRYFSKESDFISRFIRHHKPPHEALKYFSALDWTRGIFQNDKYEPVAFFPRYVDKQTGENTFFGSTVNTPATIPRLLALRRKALGAVDPETSSVTATEAAEGLHGRSDALCLMTLKEDLHAHPSIVHGGFQGVIFDEIMRFVILLHYDRTAQPGPRRRHYTLQMSLSYHAPVLTGGDILVRSWLTRREGRKWFLGAEIVDPANRDLTSAESMWLTGRTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDG3</accession>
    <name>A0A5N6TDG3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_134794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742581">
        <property type="protein sequence ID" value="KAE8144296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDG3"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024831677" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="724" mass="79266" checksum="F7D418387CF0C805" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDR2</accession>
    <name>A0A5N6TDR2_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8144416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDR2"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="72" mass="7819" checksum="C40471A0F30E81FC" modified="2020-04-22" version="1">MLNTTKLLARTWIDAKGSSMLITLFAFHAPQGIRCKTGDGSLRSGEITRRQATEPNRIGLLICIACGTSNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE80</accession>
    <name>A0A5N6TE80_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_166256</name>
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    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="83"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="587" mass="64608" checksum="FD9FEA7F258E335C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEE3</accession>
    <name>A0A5N6TEE3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_166282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="ML742459">
        <property type="protein sequence ID" value="KAE8144666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEE3"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="219"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="379" mass="41062" checksum="CF13DA81AD4E4100" modified="2020-04-22" version="1">MAHPTGTDKLTFIPSEDIDKVFAHTTNLASAALNSKVLACSNEWFAEASNLLTPTPPINRPGVFVHTGAWYDGWETRRHNPEPYDWVVIKLGVSSAAIQGVEIDTGFFVGNYGEKAELQGTYAPADSGITDAEIADPKYTGWTTILPPQPQGPKQRRAYKLNDYDPANPKPYTHVRLHMYPDGGFGRLRVYGHAIPSTLPQTVASADRPVEELSSALVGGLALEASDQHFTPCSNLLLPGRGKDMGDGWETARSRAPGHVDWAIVQLGLPGSVSKIVVDTKDFRGNFPRAVRVHGLVAGSVPGGEAPAHDHSGWVELIKGDKPCKADTEHVFEASDLATGSEDTRTFTHAKLTLVPDGGVKRFRIFGKRDAAIDAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF91</accession>
    <name>A0A5N6TF91_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_79431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742402">
        <property type="protein sequence ID" value="KAE8145002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF91"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="95"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="230" mass="26103" checksum="46551B543499C5AA" modified="2020-04-22" version="1">MVVILEKARVKSLPDDAFYIADFVTEEEEQLLLQKITTAPLPRWTHLSHRRLQTWPSALTKSDTLLSSPLPPWLVSPIIHRFKALGIFADAPHGAPNHVLVNEYRPGQGIMPHEDGAAYYPLVATVSLGAPIVLDLYQKGQAQPQHRILQERRSLLVTTKTIYTDLLHGVAETTKDERLSPDSICNWDLLRERDQFQCGWCERETRISLTYRDVLKVAKVGNAMKFLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFC0</accession>
    <name>A0A5N6TFC0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_134109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742391">
        <property type="protein sequence ID" value="KAE8145074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFC0"/>
    <dbReference type="OrthoDB" id="5417628at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="528" mass="58648" checksum="F93276DCA754126C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFV2</accession>
    <name>A0A5N6TFV2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_133963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742368">
        <property type="protein sequence ID" value="KAE8145243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFV2"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="53"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8145243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="518" mass="56093" checksum="20C1E0722DC662AB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGN6</accession>
    <name>A0A5N6TGN6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="8">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_133693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="8"/>
    <dbReference type="EMBL" id="ML742335">
        <property type="protein sequence ID" value="KAE8145545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGN6"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="34436" checksum="BADD23DDF1AA0244" modified="2020-04-22" version="1">MTELLADPCSHQRVCEAYSFLNERLPKSLKKPQVAIVCGSGLGGLADTINDEPRVEFDYSSIPHFPHLTVPGHAGKLVFGLLGGQVPVVLMVGRAHYYEGHTINRVTFPIRVFKLLGIDAIVLTNAAGGLNSEYAVGDIVVLNDHIFLAGLAGIHPLRGPNAEEFGPRFPPLSDAYDLELRRHVHKAWKEVVRSESQRRLHEGVYAFVGGPSYETRAECRMLHLLGADVVGMSTVPEIVVARHCGIKVLAFSLVTNSAVLSPVPRGDDRLLQDKAVEDLDAILQEGKASHDEVLEAGRSAAIDMQNAFEEVQQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGQ5</accession>
    <name>A0A5N6TGQ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_68579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8145565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
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    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
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        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="795"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="403"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1688"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1201"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1698"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1712"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1987" mass="223173" checksum="2D7C77DD6B866054" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGW2</accession>
    <name>A0A5N6TGW2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_133679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="ML742333">
        <property type="protein sequence ID" value="KAE8145566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGW2"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="849" mass="92363" checksum="340F2B0A392D4481" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THN7</accession>
    <name>A0A5N6THN7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_163735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="ML742308">
        <property type="protein sequence ID" value="KAE8145842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THN7"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000014">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="181"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="340"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="488" mass="55020" checksum="C17BD8CC28C0B820" modified="2020-04-22" version="1">MGQEGSPLPEGISSLLDTDLYKLTMQCAVLKYFPDVHVTYGFTNRTPHMKLTRGAYNWLLKQMDRLANIRVSDEEIQFLKKRCPYFNDAYLNFLTTFKLKPTEQIEIKFTPIKDTGSDEDLGDIEYLVHGLWLDTILYEIPLLALTSEAYFMFSDKDWDYNCQEEKAYRKGCTLLENGCIFSEFGSRRRRDYHTQDLVMTGLMKAAEEGKKQGWKGKLTGTSNVHFAMKHDVDPVGTVAHEWYMTIAAITDDYENANELALRYWLGCFGKGVLGIALTDTFGTPAFLDAFRKPIPAFTSAGVGAVSTSASGPSTTTESNVQSEAETHAPITAPIHSEYTPSSDETYAQVYTGVRQDSGDPVYFVKMVRDFYDREGIKDKRAMVFSDSLDIEHCLEYKVIAEEAGFQPVFGVGTFFTNDYTNNSNGEKSKPLNIVIKIATANGRPAVKLSDNMGKNTGDQQKVQEVKKKLGYVEHQWEQGDESNRWSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THV0</accession>
    <name>A0A5N6THV0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742303">
        <property type="protein sequence ID" value="KAE8145897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THV0"/>
    <dbReference type="OrthoDB" id="2730545at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="232" mass="26604" checksum="EACC3F19FC0AF6E3" modified="2020-04-22" version="1">MNPEHEKKAHINRYEPLRLLRRNKVPCVVWFEDTLRYYGVPTVLFDLYILVPNIEVAANLLIKEGWVLDTQGPAMIGNAEVDLPQSRLVSVCGQKKTVLLPASDWKFAFPWELQQRASYFPSFPEFLDALVESWLDCPFEDPFLLLHLACQIGYLYAHAGALQERAFAKSLKRQHRQFHYDVLAGMVTGTAQFRAHERAVRDAFLQGQYELQECSAYCDNAQLFPVASDAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THZ3</accession>
    <name>A0A5N6THZ3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_163432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742296">
        <property type="protein sequence ID" value="KAE8145988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THZ3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="60" mass="6622" checksum="F56A20DAFFB8E12C" modified="2020-04-22" version="1">MNFPKSTPRRRLGVQIVTVGVHLSSQLTPTSYTSFTTNVYQTGKPFHTFPLPESVTAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIB0</accession>
    <name>A0A5N6TIB0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742288">
        <property type="protein sequence ID" value="KAE8146072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIB0"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="479" mass="54254" checksum="86B6B43B9D7BF09D" modified="2020-04-22" version="1">MSLPAKGPYLRTKLRNGRIQNPERDDKAQRWNPITSQHDAFDACSASLSMRTGPIFSRIPTPTRSISTLYSHAGYKRENRRSALSAPGSQDVKLNMNVREGVNENPNNAGREKRISNENAAQWLEFQRRPFHLDVAPMHRLSDPYCLKTNEDTRLQRAITRSYPQQPQQDTPVTRLFPVPIAIKSKSRHSGKLPVARYATGSPSTRLSKSASLSTSRFEAGVHRKLKVDEYYEGIVTPISNDARGISFRKERVENHLVPTQTLRMYSQLTGSNQTRAPETEYNLGIPSEKMGYIRKGFRWTNSYASVKIENRTERSTERSTVSRPSNSTARCQSAARLSPLPDTRTAKPKDQSGRMLLSRSLSTGVRSKLKKPGLTAYVDFVSQVSGSQPQQYWLGRFVTLMNAFHYEDSFNKPDIATGFGMLSSYSRPLGHLDSNEADYRIKRAFMVLENVCMNEEASASLQQFRHAYVSKFGDRWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIF2</accession>
    <name>A0A5N6TIF2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3128 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_133178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742284">
        <property type="protein sequence ID" value="KAE8146133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIF2"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22826" checksum="BE6F4289B5F97283" modified="2020-04-22" version="1">MGWWWSSSKNESQAPPSSNAQPASNISSSLPSPPQTMTREEQADAEFKQLLASLEADVNKASSTSPQPSESNESIPQSSPSSIAPESLYPDTMSCRSAFDYAFFCQSFGGQFVNVYRYGELRSCSEHWDNFWLCMKTRTWSDGARKNAIRDHNRKKAIKYKTGPSSEDVWDLRTEPVRNAFEGDFAALEREMQAEEEAQKAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TII9</accession>
    <name>A0A5N6TII9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742289">
        <property type="protein sequence ID" value="KAE8146070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TII9"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="484" mass="52901" checksum="DED43C5E986BB06D" modified="2020-04-22" version="1">MPRFDDADFAVDAAPAAQGAGVAPPARSPRDSRGSGSLPIPSDAGATIEIPATRSSISDAAQFMHNLSLSPSTRDRRGSRNSFGTSLPIPRSPRVSRLASVVTADGNSVSRDILASQVQDMSKEKVAAAKNMAFAFDIDGVLAHGNHPIEEAKQALKMLNGDNELGIKIPYILLTNGGGKTEAARCQQLSEVLDCPISTDQFIQSHTPMQALAEYYDTVLVCGGEGQKIREVAESYGFKNVVHPKDIQAWDPTVSPWATLTEEERAQAKPRDFSKVKFDAILVFADSRDYQTDMQLIIDLLLAEDGKMLTRAKDPVSTRIPVYFSQGDLIMPTDHRGPPRLTQGLFRISIEAQYKALTGVDLERVVYGKPERATYTYADEVLKAWMEQIHNENRLPQNIYMVGDNPASDICGGNMHNWNTCLVRTGVFQGGDNDPNNPANFGVFPNVLEAVKTAVRKELGQEFKFKWNPKVNPVLHGDSGSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJD1</accession>
    <name>A0A5N6TJD1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_143648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742259">
        <property type="protein sequence ID" value="KAE8146478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJD1"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35117" checksum="6B442E7D11E7BF87" modified="2020-04-22" version="1">MRSSSTIPADGLVVDSAFWDKERCDMDIDRGPWTPAVDYIKALALGEIAWIQRYAKPRTPDDPLYVSNSQNIPSGHISLLQKYLFVAPYLLPQEEDILGPILWHPDLCTPNIFVNDRGNITSIINWHSTWAGPLFLEGRHPHFLQYYGEIMLRLPKDFRQLDTSTQAGLREQATKSILVYLYERYMTNINPTLHRVFVYPNGLTLSDPVRFAGSTWEDILPLQESLMRVVTKWDSINDTVKCPIHFPPEDRCKHYEEGEGWNEIQDFWDTMTGILEKDSWTSHETYDRAREIFAKLQAPAPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJE8</accession>
    <name>A0A5N6TJE8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_51745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJE8"/>
    <dbReference type="OrthoDB" id="3880384at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="164" mass="19497" checksum="5E461BCC77D2FA26" modified="2020-04-22" version="1">MAPNLFLCLRNVFCPTYWFQRGERIQGSIHKEEHWDSPVPGIYKYIPGQGWHLVCKDGNDYDEKVPVPLVYCRILHRYMFEHELEERCRWHSVTVHEGAKPERFLFFRLDDGDTWVAGWDAKGKFIPGPYQKWYYDSVKRTMRRVLFPESSNVSRASIVPSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJQ8</accession>
    <name>A0A5N6TJQ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_169792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJQ8"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="574" mass="63209" checksum="97B2CD93B219C239" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKA1</accession>
    <name>A0A5N6TKA1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_161757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKA1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="53"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="299" mass="33245" checksum="9D829B2F123A83C4" modified="2020-04-22" version="1">MKQNKTMAPVQLTFLTTGTVRIRPSMRSQPANGYALMRRLRSICDREWTEPFPIGVFLIQHPEGLFLFDTGQSPCCNDSGYLPRTAVFSSLLSQFIIERKDGTLEQLHARGIKATDLKAVVLSHLHTDHAGGLEDLVAEAPDLPIYISREHWEAFGKHPLYASFEGSTPNHWPEPFTPSIVDFEDAPLGPWKQSFPLTSDGGLVVVDTSGHVPGHIGLVVYSRSEDGPLTTYFLPGDATYGIDLLDREEPDGINDDPMRALQTLKTIKEFARQTAVVVLPSHDNNTPRLLDQRVVYVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKT4</accession>
    <name>A0A5N6TKT4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_132491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML742233">
        <property type="protein sequence ID" value="KAE8146957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKT4"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000007">
        <property type="entry name" value="5-formyltetrahydrofolate cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="170"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="240" mass="26658" checksum="CC2DC7AB3A46EBDC" modified="2020-04-22" version="1">MMAGLQTAKKDLRRKMRDVLQKIPADAITNQSRTATNKLFSLTEYQHAKKIGVYLSMPSGELSTTAIVQDALINGKQVFIPYIHNIELPSAQQKTSIMDMLVLESMEEFNSLTPDKWGIPSLAKAQVANKTNCFGGTGISSSADEPNPTGDWGLDLIVMPGMAFDQGFRRLGHGKGYYDHFLNKYSKEVENKTTPKMPLLVALSLKEQALSPTEQIPVANHDWPVDVLIVGDDRCLVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLB3</accession>
    <name>A0A5N6TLB3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742223">
        <property type="protein sequence ID" value="KAE8147147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLB3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="552" mass="62124" checksum="F80E08A9501E167E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMV1</accession>
    <name>A0A5N6TMV1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_131925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742198">
        <property type="protein sequence ID" value="KAE8147630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMV1"/>
    <dbReference type="OrthoDB" id="4183264at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="456" mass="52522" checksum="A742CA5C7D7E741C" modified="2020-04-22" version="1">MEIFNLFSARSSDAEDEESIEVSATAPIPIPCSAYLGDEDDAREIQIAEAENEIIDALMEDFTKGFNPSTFHQEVMAILPILSKDVLPGSYEHLLVILLESNDRMQEIQYQLQIWLRDRYQCWAFTHPDLVSIADETYFVSELEILRKLLAPFRGEGESHIYWINNRRKVYKKVREELEAAVRVIELFKKDLYLELRTVDETKTFYTTLLVGQQRTSIMSVKHRRLDACKASMTWDGYAESDMELTVFHQYYKNYLSASEPEKARELSMLPPSDLIAPVASSEKAVPGDLAHWPYEDKNGLIHLLIKMALWLSVGRGLSAVHLFCDIVRYFTIDGPPEDAKDDLISYLEFLTQIRVSDGSIKSELPTPIPYRDRQQSENNPDYFSDVWHSNKSLGVVLVENPTFFKQPVPKLELFEPPIRRTFRKEMRALKDTVEITGSLVHGCPHGEVRPNERHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMV2</accession>
    <name>A0A5N6TMV2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_168962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML742196">
        <property type="protein sequence ID" value="KAE8147664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMV2"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="13"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="501" mass="55647" checksum="913686015D387FB9" modified="2020-04-22" version="1">MTAPKIQHQRLNAKFKGIERKIEGTAVHQFRGIKYASIPARFECAKPVEGFNGAVVNASRYGPRCPQVDVDVRHLLRIPEDIEIPIEPEDEFECLHLEITCPPLSSDSEALPVLVWIHGGSQVVTFCSAASKICDPVKIVADSIKAGQPIIFVSINYRLNIFSFGDGKEKNLALKDQRLGIDWVRGNIVEFGGDASNITLAGESAGAVYVHAHLITGPPVKRAVLASGSLYLSSPLPVEKGDGLIKALEAKVKDLEQPSLRHATVPVLIQALKESYVNTMWIQEEPELRDWESRPERVDELMIGDTEYESIIWRNGVETLNGQTIASAFEQDRQWGMKLRKMYQVVPDRPTASKLGALDFINDTRYALPVELISEKCKEADKPVYRYVFDQCNPWQASSRAHHAVDLLFLFAGVDLSFSPAAETVSRQLRGCWISFVNGISPWSVEKRFAFGPLGECRDITEAQFASRRRVRHIEALKEAGLGVYMPIAATLAAGKISLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN23</accession>
    <name>A0A5N6TN23_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_29031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN23"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="161" mass="17957" checksum="B000CCEFAEA6706E" modified="2020-04-22" version="1">MAPHSDDALTKVSTDAAMEFVQSFYPALQSDRAAIASFYNQTTSRILFNGNTVADGKAVQDIFVNQMPPAHYEVQSFDCQIINQAYPTPTPTGLKLPNDATLKDKSILVLVSGYVRFGESRDLPQRGFSETFVLVPNPSDGPRGKRRREWLIETQTFRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNH1</accession>
    <name>A0A5N6TNH1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_131682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNH1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="603" mass="67638" checksum="B0C9EBDEFA635F86" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNT7</accession>
    <name>A0A5N6TNT7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742178">
        <property type="protein sequence ID" value="KAE8148026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNT7"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="480" mass="55039" checksum="089DA7470FE26C03" modified="2020-04-22" version="1">MDYNKPLDLLHMVEESDWVRKVNMARVDGRICDWARGFHPKNIPCRLDGGFLNGSYNLGQKIIFDDGSTWFLRLPRASSISPEYADEKVAMEVEALYLLREEASIPVPEVYAWGFAREDQLGLGPFILMSFISGVCLNDIFGGDGSRLLKKEIPDTDIEYVYRQMARFMVQIFNINFERIGSLPTPKTQFPAPIRPLTWKVHEILRVGGVNTFDDRNEDFSTAREYFQYVNRQDWNQLLFQPNSIAGPRTAKSRYASLKVLKSLIPELTNTTYDRGPFKLICDDFGLANVIVRSGDDLTITGVVDLEWVYAGPAQLFGTAPWWLLLDRPVNDEWDFEEGEAPKATDRYFRCLEIFKRVLAEEEARMTGFRNKELSTLIKWSEDTGAMWFHMLLSSGSFDTASFPCMQLRKHKGEEWWAKNLDDYANGEEVETFIASKLEGLEAYDKVKDTVEHIKALMDSGEMTTKDFINTVTALLHPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNX0</accession>
    <name>A0A5N6TNX0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vta1 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_159126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742179">
        <property type="protein sequence ID" value="KAE8148010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNX0"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="398" mass="42944" checksum="0452F35947858195" modified="2020-04-22" version="1">MANNIPAALKSADIGRFAVRAAQLERVKPVIAYWCNFWIVNQIIERGLHTTDDEVKLYTTDLVDKLEQFKSENPDNETVLDAVAASAYVEQFGLEILGRAETTMRANKVTKQTADTFQAAATFLELCQIWNPLEPETAAKVKFAKYHAVRIVKAIKAGEDPNESNPVITEEEEDLEVKTDDPEVQAIVGSPPAQPGQPSVEDVPDESMRPSRSSPTLPEPPTEIPASHYAPRTPSRNMDLDTEQDAPLNLPSAPATLTSSSTSVPHLPDTPSGPSMHQPAGAHDAFQSFPPPSAMPQSPPTVSHDPSAFYSQPSRSPYQPAQSPAPVAPRPAPQPVAVPAPITSTGPSSNHASSQAVDDESIALAQKHARWAVSALTFDDVNTAIKELRNSLKHLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP53</accession>
    <name>A0A5N6TP53_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP53"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="85" mass="9245" checksum="B02D97CBC09597AB" modified="2020-04-22" version="1">MMQQLVKGQTATPRPASSNQPKVPSTAAKVTSLLARQQNPFRIVSWPCHSRGRLNICSDPLFLSCKKAGTVSGKRHKVSVAKQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP60</accession>
    <name>A0A5N6TP60_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_131670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP60"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="432" mass="50207" checksum="EC0E961D857AF3ED" modified="2020-04-22" version="1">MAIPWNIRGSASQILFQDRTSSQYRALLAIADVPHPDRSILEAARYFLHRICTEDASKEPPEKIKLEFLSEWKTLVDKFRPTLATSISNETKTLIYQRDGGRCCLTHTPFKSYLDPGIEYVHMTPPCVFTDPDLAEGYTVDANLFRPQCDPWLYTMTDEVLLDNKTPELTPIISEELLHIHARFSKSLAWMDAKQYMDTSVDNGTERRSSRPLLASPFSLFRHCWLALSSYIRASIYDALVWVGSRIYGPSLSMTVFRLPFGLYLRRGSPMLASKYHVEAHTLHMIEQFTHIPAPRAIDVLQSSRTMTDEQVKQAVNDLKEYLFELRKIPPNTTEFQICNPQGGGILDWRLSDSQREELRFRSEADFNKYLTDPFGEEIRKRWFPEYWEYTKAHFSVRSLMRWLADVVDQVFEGYRDELQVENMLSDLLSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP72</accession>
    <name>A0A5N6TP72_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742172">
        <property type="protein sequence ID" value="KAE8148153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP72"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="379" mass="42774" checksum="16F1E310497E8AC4" modified="2020-04-22" version="1">MPSHRLDRRTGQTYSETTSARASVFSKGPSWVHETPFLTRGWEETNEFGSPSLKHSAMRQTLSDQRNLVPQLFENVPWRIAAYLWDCLGRSRKRTFYMWKVFATAYPDEFRQIAQHRSMKIEGPRLPMRDYLEMVKSENLRWRTVLTIVNSHARVPEMVDVSSVRNLVALEVSTPPQINSCEDLETPMAALSDRIVRTWSELAEGSGGFAHVRVLKLCHQDLSEVALRYLRALPSLQVILVHDCQGIHSVATSASGAAGWEYRRLPGEEGPPTLYELYQTSLTDQNKAEPTLDRDSPILDFQIGQASRTPTRPKNAQTLLLYRTGATVRSPTEGSGPQAKRPKVGVSAGGEAQKRLGPRRPVMKDRKTKDLAEVLGQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPD1</accession>
    <name>A0A5N6TPD1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_159209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742181">
        <property type="protein sequence ID" value="KAE8147991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPD1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="583" mass="63948" checksum="4063A35735FD5F9E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPV8</accession>
    <name>A0A5N6TPV8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_141854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPV8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="434" mass="48158" checksum="7444D5FA83E90C45" modified="2020-04-22" version="1">MADVGDRMFCHACGGVWLRSDEHELKCPHCQSEFTEIIEIPPDTEAPDPPTSVPEARSFSDNPLRDHNPWEHDDSDDGEWDPGNGFRHRTYRSPDGRFTFSSTTYTSGGPRSAPRQPSADPLMPMVRGLDTIFHGLADTYRQTEYRQHDQRDFDQERGMGAGPNLGRGPRMFSTSFDFDLDGRRGEGMRSRSNPREGLHPRDADSPQPMATPLGTLGDILELFRADFGTNMQRDRENPVMTGPNPLSILSTLLSIDRRGDAVYSQEELDRVISQLVDMNGNRSAAPPAARSAIQSLPKKAVDREMLGSEGKAECSICMDSVELGTEVTVLPCKHWFHYNCIEMWLTQHNTCPHCRRSIDVSARPEGSSDNPVVISDSPPTSRRSSGHSPEHRHVPEQGGQSPWAGGRSQEPEQAQGNSHGGFANWVRSHFGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ28</accession>
    <name>A0A5N6TQ28_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="12">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_168489</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="12"/>
    <dbReference type="EMBL" id="ML742162">
        <property type="protein sequence ID" value="KAE8148397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ28"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
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    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="30"/>
            <end position="391"/>
        </location>
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            <begin position="436"/>
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            <begin position="265"/>
            <end position="271"/>
        </location>
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        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
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            <begin position="401"/>
            <end position="434"/>
        </location>
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        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="109"/>
        </location>
    </feature>
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        <location>
            <position position="284"/>
        </location>
    </feature>
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        <location>
            <position position="612"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="113"/>
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            <name>substrate</name>
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        <location>
            <position position="163"/>
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        <location>
            <position position="207"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
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        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="324"/>
        </location>
        <ligand>
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            <position position="327"/>
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            <position position="359"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAE8148397.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="740" mass="81494" checksum="49A880555A169119" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="UPF0676 PROTEIN C1494.01"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="182"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="368" mass="40480" checksum="BBE8ED394851F1AB" modified="2020-04-22" version="1">MATEETPTGSLIQLPILDISDPSDPAVGKAMLDAAAKYGFLYVNSTGTDFAASDVEKAFDLSKQFFKSPFEEKAACRIQPNNHGWSGMHVETLDPEHQRTGDFKEAFNFGEFQNGKAQQPLPQSLAPHEADIGHFADLCNKTCDRILMLLALGLEIQDDFFTARHDPNKGPTGCTLRYLYYPSIASQAVSSYEHGTDVRAGAHSDYGSITLLFQRPGQPGLEILTPEGTWAPVPVEPAQAVKDKSATFPFPPILVNIGDLLSYWTDGLLKSTVHRVVFPLSEQRDPNPQDRYSIVFFCHPLDRTELVPVPSDLVTTHRQRCKESGAQDEKVGFGGGAGNLEPGKRALTAQEHLMSRLAATYKFNDEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRS8</accession>
    <name>A0A5N6TRS8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_8398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742139">
        <property type="protein sequence ID" value="KAE8148994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRS8"/>
    <dbReference type="OrthoDB" id="5399817at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="125" mass="13625" checksum="8CCA472078776B97" modified="2020-04-22" version="1">MPTSRTLSASAISFAVLSIGHTLGGIQWTNDPAHALITGTKPWSCGIVGWYQGSAFFLMTSLIHYQWSRNPRALQDPTNKAIALITNGLLWASSAWYFRTGIVENGWMVGLSAALQAWAVVQNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRW4</accession>
    <name>A0A5N6TRW4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative hybrid NRPS/PKS enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_141197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742137">
        <property type="protein sequence ID" value="KAE8149034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="8"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="968"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2422"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3583"/>
            <end position="3662"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="968"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2506"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2511"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2523"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1000"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8149034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="4016" mass="438755" checksum="6874E578BB27D678" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRY4</accession>
    <name>A0A5N6TRY4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_156934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8149116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRY4"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="55919" checksum="9C85796CFACB151B" modified="2020-04-22" version="1">MHPSNGLDSKPSPESSVESFSTTEKDATCVNVVSYDVESGEQSQDEGDNIVHWDGPSDPANPMNWSEARKWITIGLISLSSFNVSMVSTIFAPGVPEVLKEFHTNDSSLASLMVSIYVMGSAVGPLILTPITEISGRLPMTHAANVLFMAAAIVCAASINMPMLIVARLIMGVASSVPVTVGGGFVADMMPMERRGTAMTIWTVGPLMGMVTGPIFGGYMVETIGWRWTVWLEAILGGVIVIASVILLRETYAPKILKQKARKFEKATGQRYCTKFDSDRSAGQLLLTSLARPIKFLFLSPIVMIVSLYSSVTYSYMYILFTTFTDVFENVYGFSPGQAGLGYMGLGLGFCFGQITVGYYSDRHLKKQEKIHGKMKPEDRLPPLVVGCFLVPIGLFWYGWAAEYRVHWVVPIMGTFFVGAGIYYVHLVTQVYLVDAYTRYAASAVSAELALRCIFGATIPLAGTPLYDSLGLGWGNSLLGFIALAFAPTTYYLLKYGERIRTNPKFMPKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSC9</accession>
    <name>A0A5N6TSC9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_4543</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSC9"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="575"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8149262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="608" mass="66027" checksum="B1BD27CE1377CC10" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSM7</accession>
    <name>A0A5N6TSM7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_7598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSM7"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7563" checksum="AF2362E02111E5C1" modified="2020-04-22" version="1">MEAKNPKIFGDYGGTSRMFSMVEVAFSLGAMLGPLLSGSLSEAVGYYYMNVTLATICLVLGSTCFSFFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSN5</accession>
    <name>A0A5N6TSN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_156583</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ML742127">
        <property type="protein sequence ID" value="KAE8149310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSN5"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="66"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8149310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="396" mass="44825" checksum="4FC070FF5C92CCAF" modified="2020-04-22" version="1">MKLDAKAIRYLTAEDFRVLSAVETGSKNHEVVPTPLIAQISGLRGGSGVNRAISNLAKTNLIAKVKNAKYDGYRLTYGGLDYLALNAHQKQKCIYSVGNQIGVGKESDIIVVANNKGTQRILKIHRLGRISFRSVKNNRDYLRHRSSASWMYMSRLAAMKEYAFMKALGQNGFSVPEPIAQNRHTIVMSLIDAFPLRQISKVPHPDQLYSELMDMILRLARFGLIHGDFNEFNILIKEEEDPDAKGKAPADEEDENLRLVPVLIDFPQMVSIDHVNAEMYFDRDVNCIKRYFQRKFRYVSDEPGPFFKDAKKQLLENPGTRLDVEVEASGFSRKMARELEAYMKEVGANEEGEGQGSEEEHSGSEEEEEEEEEEGESADAIDESSRRLDELHVSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSZ2</accession>
    <name>A0A5N6TSZ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSZ2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="344" mass="37442" checksum="90E3473AE0574DD6" modified="2020-04-22" version="1">MSQNKALVFKQIPQGYPVVGQDIVVENVSVDPSSPAPENGVVLQSVYTSFDPYMRGRMRSAESKSYAPAFPLNQPIDSRTIAKVLRSNNSKFKEGDLVIGFVPVQEYIVLDSQNVARISALENPLGIEDIRVFLGALGMPGLTAYSSLYEIGKPKKGETIFVSAASGAVGQLVGQLAKHEGLKVIGSVGSDEKLEYITKELKFDGGFNYKNEKPADALRRLAPEGIDIYYENVGGEHLEAALDALNNFGRVVVCGLISQYNSAPYPIKNFQNVLVKRLDVRGFIVGDAGMGDKYAKEHQENVQKWIKEGSFKALTHETVGIDNAADGLLGIFHGKNKGKAVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT14</accession>
    <name>A0A5N6TT14_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT14"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="36763" checksum="F89FB4EE42D6202A" modified="2020-04-22" version="1">MSRIFITGATGYIGGDVLYALTQAFRSCKITALVRSEKKASLITSRFPSVTPVIGNLDSAAQIASGASEADVVLHLASSNHLPSATAIARGLTETKRQSPVWIQISGASLLSGAEVATSSYGQARAQNHNDLQGIGEIRNIISSSPKRAVDQMLLNFSSEQPNVRTAIIYGPLIYGLGRGPVNQRSIQLPDLAKATLQLGHGVQVGKGLSGWSNIHIADLSNLIVRLVQESEVRQGGNPSLWNENGIYFAENGKMPFGEISRRVAAFAFQNGFTKSTHVEEIDAEMADRLTAHGAVLWGSNAQVTASRARELLSWKPAGPSIAEEIPRAVMDEALRLKSRPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT34</accession>
    <name>A0A5N6TT34_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_2167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT34"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024950696" evidence="11">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="228"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="34532" checksum="1F896EA8EA717102" modified="2020-04-22" version="1">MPTDALSILLASTSASLALDLLIHPLDTIKTRVQSREYTQFLERNRGAGIWKYPGISRGLYQGIGTIVAASFPAAAAFFLTYEYTQSGLQVVRQKFGSDESSSIHVLSDFCAASAADLAACVVYAPAVALKNNAQMIQSEQPNISGPMTGRKLKVVAQSATSLAFKKFASPRQLWSGYPALVAHSLPVSVIQMPLYEAFRHYITEYRLEDEKSSYLEPEPKSRERKQRQITIKEVSVTAATRIMLDAAHTNAAQQQQMIKLVQEILRADGLRGLFRGCTINSVMMGLGSGLYFGLYESAKCWLRKGSPGAHLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTF2</accession>
    <name>A0A5N6TTF2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTF2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="19022" checksum="478AA5F3CB0F4928" modified="2020-04-22" version="1">MPDWTVGSSPGTADVHPDNSLTFQVLLVVCLSVYVLTAIWLLIRSYCLAYSSSIPTVNDSTANDARPPTNMEQRLQFLERAAPTKPFKTWWMSVQTIKSPLKKSDQLFTCSICLDTVHRKDPIHALKCRHVFHRQCLEKWYLGDHNHCPVCHKAFFEEPPRDPGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTM4</accession>
    <name>A0A5N6TTM4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_155770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTM4"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="601" mass="69310" checksum="AB4DFA8FA3247EDE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU86</accession>
    <name>A0A5N6TU86_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU86"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="247" mass="27716" checksum="1C08F73F10873DF4" modified="2020-04-22" version="1">MYNVIQQLKKAEQTMDAMPEQLKSLSGKFDRTIAILEVIKKQKELHTEIVQQNVVAVTEDCKVLQSYMDRLSAEIKHRKVRQLFHALVSGEEDKQELDGILNSIEQSRNGLHTSISVALVSLVGDIKKGSYGVSFNALINTNRGFRNVTGDDLQLVKQLNGRQPDSDGYFKLNTADLEQLGLTAGGCQRQSTFHDNKTRGKATVYIDTFAKKDEVAVPMDMYNNEFGPELRVVAAHFDPHLAMKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUA5</accession>
    <name>A0A5N6TUA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUA5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="156"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="398" mass="45663" checksum="6B8488CEC7E79F93" modified="2020-04-22" version="1">MPSIELKSYQEDEDYLSQENPEPNRRSQYLIYHHNSNSKKWWIKVTLLGPVSSTSGPSEIQKSTKRKRREEFKVFVQLINFESLPLLRDTVTELILGKDLEATTTLKLNHGAEDSLNENVEFFSNLKYEIREDPSRVNYPPCQDFLFFRRFHAAQLTDKEEIVDGVFRVIHHGIPFILKVVDRPFYQPRDTYVLRQELENLRQFQGVPNIGQAAGIAVDSNPYSTSMTADQQQVVVGIMLEFYSGGSLQQVFDGDCFQNYAWEKWPLQIATALSCLHRAGKTHMDIKPSNVVLDSCGNAIIIDISGIGGITRAWCAPEIQNEISPFELSFNLRQWSDVWSFGRLLLEITKHAKQNHYVKHLKSIAEELTKEEISKRMSLADAIPQLTPPGSWERCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV06</accession>
    <name>A0A5N6TV06_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_114507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV06"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="221" mass="25660" checksum="6E592E370DADDECA" modified="2020-04-22" version="1">MSLQPIKLYGHANGPNPWKVALLLSELGVPHEIDFMQMTEVKKEPYILKNPNGRLPTIEDPNTGIVLWESGAILEYLVETYDKERKFSFEPGTHEYFHTKQWLHFQMSGQGPYFGQAVWFSLYHPEKIESARVRYINEIRRVSEVLNTALAGREWLVGGKFTYADVAFITWFGVIPWITGDEIDMEKDLPNLYAWLQRMKARPAIAETLKRKEEINAKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVZ0</accession>
    <name>A0A5N6TVZ0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVZ0"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50266" checksum="FDEB39BD3C8284CD" modified="2020-04-22" version="1">MGWTQVSQRRWERPVNGIEGYFTVLRNMIAPLCGGREHFTLFAKVKVEIDVSDAEGALRHAWKQIRYEQPQIATVVEDMKKVYEVPDETGLEEWLRATFIVSSASDAEELYRRAEPVSRATLYYVPLSSEILVRIPHYTIDAIGMLLLLHSYFRALENPAKDVRFGDEYTRLAPAVEDTLGQPEEPTPEQLKEAIDTARQWTREMPGIGPVSKAGKAPSGQSQNLEEVYSKEMTQRIVERCKEKGVTVTSAVHGAYIWMLRKYADPTGNLSRYVTAASINLRPYLAEPYGSSQYAASVYYAIISWAFDMPETYWDGVRLLNEKYQTAIKGNPVALEKSSHFTRGLCEVVQTPEFLANAVARDALPSSLGIVEQYLQRTYGSNIAVQDFKLGVDIVQGMCLLCIYTFNDQLRLVYNFNEGFEGASDIRRYLDEMKEVLERELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVZ3</accession>
    <name>A0A5N6TVZ3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_172043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVZ3"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="516" mass="55622" checksum="ED4341D916A8F894" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWP5</accession>
    <name>A0A5N6TWP5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWP5"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="488" mass="53761" checksum="8FA5EE55A0D45F9E" modified="2020-04-22" version="1">MVQDNDHSSTTATSVIDASNFPSINSPTERKDSAQPCNDPRLSHHGLATSLAQTSDVVPPQKPTHSFHRRANTEYIVRQTPLPTQQLFADQAKTLEDLNDKDITPPAENFTRRKLEEGAKRLSGWFQGKSEPVNLGVHHSDRDSTKTTAMDTRDLYGVPRVTPRAQKRMTAPSPLKQVTSSSPFSFFGLKRQDNSSQLPEPADDELLNLDITAALFPTGSGDLNDQEAVDVLKNNAELVIKRLQAAYKQRTFALHEALAEKSEKQEELEETRTRVGNLKVQLDGMAEKVNQQEIAMKALAEELEEERQSRQREDEARMRSIRLIRSSDDESVSDIGGDLQTPKHSMKRASNATFASDSGFDSGDESLAESVFSRRDGHESPASTVAPSPSVSQVTLPAPVSTPQKELKPQPPATSSQTSTPRQSAYDRVIKGIASHWMNNSKCGICHGVPSSEAWSVLGILKEENKGLKERLGELEMVIDDCLSMIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXN3</accession>
    <name>A0A5N6TXN3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_153369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXN3"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="303" mass="32013" checksum="6E93F641FB25A54F" modified="2020-04-22" version="1">MSISSINTSIKGLLSNYSPVSECSSHPDFEKEYLRDGTSSDLESSADKPNRGRLGSEKSESKIIDGRLVSDAIIGLSDGMTVPFALTAGLSALGDTKVVVFGGLAELIAGAISMGLGGYLGARSEEDSYHATLKETEKQTMTDPSGVNDTISDIFAPYDLPPQLVSDLTMHLSSSPMLPSFLMNFHHTLQEPSGSRAFICALTIALGYFIGGFIPLLPYFFVGPNDAFIALRWSIATMAVALFLFGYGKTCFVSGWKGRQNIRHGLIGGFQMVIVGGVAAGSAMGLVKGFQLLASAGDNGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYS2</accession>
    <name>A0A5N6TYS2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_91385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYS2"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024936812" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="39"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28407" checksum="D0B02412E5608323" modified="2020-04-22" version="1">MHALPGEPAHKCSATEHHRMAVLMLLLPLLLVISFGRAETCYWPNGDTAPDNYHACPNSKVCCSAGEACLSNGLCYGANLNIAYRGACTDKSWPIAECTRVCYTEIDNGWANLYPCPNNTNQVFTCGAPGWASSVCEADLGTVTWPSGDVSYAKVSNSTTTSSTASSTSTTTGATGTPSVRESPTDAAESNKSSDNSVALGAGLGVGLGVPLVLMSLFLFILWRRSKKQVAQTYATPAPVMVEPKGSYGHTMTVGSELEGSQPPVRELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYU8</accession>
    <name>A0A5N6TYU8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C3HC zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_98832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYU8"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="278"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="434" mass="48496" checksum="D79CE0E582B5EE84" modified="2020-04-22" version="1">MSYAVETKKRKFHRVLESLTKPSTPEPSSKPAPATPKERASADLSTKKLRRENETDLESVRKSILKVARPSSRDSTVSSASRPTYVPWDRERFLERLETFRRVDRWSPKPAAINELEWAKRGWICTDVSRVTCIGGCGGSVVVKLPDELDELDGYDSEKVQERKEVRAKLVEEYANLLVTGHGENCPWKNKGSDATIHRLALSNPDAAISGFQTRYTNIVKMGNQLPSQDIIQTPESFDIETIIRILPHGFGDNENTDDAPQTPQPSDSNKDMINRTALALAFFGWDTVSDGAAGLAGCSACFRRLGLWMYKPKENGDVSVYDVLDVCNEHMEYCPWVNGKAQSGTGKPSEKPTELRSGWEILAQALRVKHRRSVRSTASIDSRAVSESPSMDGSVFDETNGEAKKASDREWWAKLRRMRQVLNVKSPKKPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ90</accession>
    <name>A0A5N6TZ90_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">dTDP-D-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_128629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ90"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="55"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="379" mass="42247" checksum="1A645E203EE4049D" modified="2020-04-22" version="1">MAPAATETLDITPDITPGITPDTSVSPSDSGEVSIDTFLTGVYKFQPLSNVRTILVTGGAGFIGSWVTRHLVRQYAETYNVICLDKMDVVASLNNILDLFACPNFRFVHCDLNDQDTILFALQTYHVDCIMHFAASSHVQNSFSDPFTFTRNNVLGTQSLLEAVRSYGKISRFIHVSTDEVYGETNGQMATEASTPMHPTNPYSASKAAAEMYVMAYQKSFGLPAIIVRSNNVYGPCQYPEKIIPRFANLMLKGHKLTLQGNGNNARRFLYGADAADAFDTILHKGEIGEIYNIDSKYEVSNRKVAAMILDLFGHDPVKGFSNMVTWLPDRPFNDNDYAVDGSKLHALGWTQRVDFDNGLAMTVDWYRKNMSTWWHQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZB9</accession>
    <name>A0A5N6TZB9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZB9"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="557" mass="62757" checksum="EB841BBA46E49080" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZM1</accession>
    <name>A0A5N6TZM1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742064">
        <property type="protein sequence ID" value="KAE8151817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZM1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="120" mass="13852" checksum="3F01A891C47C5399" modified="2020-04-22" version="1">MEQQTQPEPQIKTEDTSNDPDGRNPLLHSNCRAGRAYRRWIHDIVTTLVPRLTTAQLRQLKEWPEEERDVHGFITNMGLVRQYVPWDSGDPSKPITDQLAREVLGYAISLADASRMMCQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZY8</accession>
    <name>A0A5N6TZY8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_128385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZY8"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="728" mass="80473" checksum="3DB8A4A88FB20F04" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U098</accession>
    <name>A0A5N6U098_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_151743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U098"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="174"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8152005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="441" mass="49824" checksum="B531458930499372" modified="2020-04-22" version="1">MARPDRRISLALARIIPSVLLCIVIYACYAVTKPLCIDYLIHPRPKYNRKPRAGAGAAIIVVFYVLLFPVIVTYLRLLYNVIWNPGFLPRGSPSVTDEEDTDTLAQHSQGHKRRKRSKRRTRAAEKPETSTEVDIESGPDNNAGGKAFDLDTAGLERFYTKDVFVCQPDGRPIYCSTCCQYKTDRAHHCREVDRCVRKMDHFCPWVGGVVSETSFKFFIQFVFYTTVFCAFALIICAIFTAELKRETGTANPHWAVGIGLSTLFGVFTFGMTISSLQLAMYNLTTIENLNRRSAVWTLAIRVPSHMLAKLNPESRWAPTFRTITYPLPPMPATPEEAPQYPQYRPSGEQHVFAILQTLPGENPFDLGSTYKNLQQVLGYSLLDWLLPFKRSPCADHTSQESAFALGPVVQRLKAEAGLEAPVASSRRSSRHKRRERSRHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0K5</accession>
    <name>A0A5N6U0K5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_151925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0K5"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8151889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="391" mass="43245" checksum="2786F1698B305B46" modified="2020-04-22" version="1">MVYIRQHQLPKLKEYRYAGVDHSLISRYVLKPFYNNFVIKCFPMSMAPNAITLTGLFFVVMNFLTILWYNPSLDQDCPSWVYASCAVGLFLYQTFDGVDGIQARRTKQSGPLGELFDHSVDACNTALGVLIFCAAMNFGQSWATVLTLWGSTMTFYVQTWDEYYTQVLTLGIISGPVEGVLTLCLVFGLTAYMGGGSFWHQPMLETIGVPKLEAIPEQVYDMPFTQWYLVYGSVVLFFATGSSIVHVMQTRRERGQDPIAPLLGLLPLAAIWAFVPAYLYLQPTILENYMVPFALYVGLTNAYAVGRMIIAHLTKTSFPYFNVLLCPLVLAVLDSAGPVLDLWPSALGSEGGQVAFLYVSLGLAVGVYGSFIVSCSTIGDVVSHSTDRVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0W0</accession>
    <name>A0A5N6U0W0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18909" checksum="158C858BF40A02C3" modified="2020-04-22" version="1">MFAFREAWNLFQYDHSSPRSDDSAFPSIVQPSFLPDMDEQSPVNNSAPGDEITANSNVELIAELRRLREDLQQLQLTSDPNIDASGEPPHPNELRDAAGQASSRSDALRCWESCCNGRTFSNRSNLIRHQRERRGEKVKLRCSFCDAVFSRRSARDAHEAGRRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0Z6</accession>
    <name>A0A5N6U0Z6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plus-3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_151389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0Z6"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="268"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="615" mass="68936" checksum="0421A91C2ABC875C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U168</accession>
    <name>A0A5N6U168_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_170511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U168"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="309" mass="34179" checksum="37BAC6A1DD70CBA8" modified="2020-04-22" version="1">MTFNRIAVYGHRGFVGSRVVPALIASGAPITVLHRSSSDTSNLPDHVRKVEVDVFDEDALVGALQDIDIVISLVGDEGTDRQYGFVKAIPRTNVQLFSPSDFCLRYCEQGMRMPCMKAKAKVEKASKDAGIPTSVVHVGNFAEFTLSTLAVGVDLQNNMVVFTGNSASERVTMCTKDYVAAAYVDIFTSRPIHTIQNRTITLSELAPTGMDIAAIMKEKNGRDPSIVTRSLQEVNQTIEDCISAESNLAVPSYCRKMWGTGEMMKMLPDDLWEVKDYKKASLEDLVLGGRLESYRTLPDHVLEYLRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U183</accession>
    <name>A0A5N6U183_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_71974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U183"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="480" mass="53505" checksum="31E76F2100B922C2" modified="2020-04-22" version="1">MDPTMPNLYGEISEFAERYYHIAKTGPILNHPSKKRLSTIENNTPPKAGRLIRDVIQEAEEILSYQLSTGHPRNFAFIPTPVSPVSWMGDAITSAYNPFGGSSVSGAGVCAVERSLIAWIAERFGLPPSAGGQFVSGASMACLTACTVARDQRLNDHTRCKGVAYVSEETHFCTRKALHIIGLLDYQIRTIRCDAAFHMNVDHLRQAITEDLEKGLSPFLVVATCGTTSTGAIDHLDQIADIARRHKLWLHVDAAYGGSVAFSSTHRKLLNGIERADSIAWDAHKWLFQTFSCGTILFREKSHALKSFASTANFCRDIEDEEDPHNPWNYGIELTRPARHMKLWFFLQVLGMNRVDQMIGRGFELLDLAVRELNKLPHWVVMAPPSLAIFNFRFAPENVNQGNLDKINERVSKELIARNAACIITTRVRGVVGLRMCTINPRTSDEDICRVVKELDHAAHAVYKDFRAAETGMTKDAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1H4</accession>
    <name>A0A5N6U1H4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_151132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1H4"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32209" checksum="1879DA0EFFB2A698" modified="2020-04-22" version="1">MHTHCEDKSTMDRPNTATLDGDNYLLIRDSAEDMRLHCQHLIWELHTQYILSPDIPVTEHMRIADIGAGNGVWPFHLSQKVPSTVQIDGYDISSASFPPPSTLPQNVKLDLLNALSEPPESLRGVYDVVHVRLWCFVIRGNDPDALVRTVGYLLKPGEYIQWEDVCRDAELVQPGPTQTFENAYTRFLQRYDINMEWVRHVPERLRDAGFEVIRHSDGPFEKLVEAMYFDNYVSAALRVLGADETVAREAMAHIVQDLSRRGRDDIRLPFRSLALVARSAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1I6</accession>
    <name>A0A5N6U1I6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARS binding protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_67553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1I6"/>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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                <person name="Nybo J.L."/>
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                <person name="Daum C."/>
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                <person name="Magnuson J.K."/>
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    </evidence>
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                <person name="Nybo J.L."/>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="178" mass="19594" checksum="A6333897D5EE5DEC" modified="2020-04-22" version="1">MYDSYRPHPLLAQVPLTVSPFINLPASVTLPYTYKSVPSTLPPSVTADPSNPDSKPRYIVSASGEHAASPEEILASCTSLEQHLKKARDDAGKAIKDWEESIIQRELAEKRRVAPGWLDREEKLLQPRRSMIPGPSGHQVQSLLDSSSADPVVSRLPSMKPRDEGEELDRAFGGLDVK</sequence>
</entry>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:GTPase activator activity"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U254"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000030">
        <property type="entry name" value="Mitochondrial large ribosomal subunit L49, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="190" mass="21074" checksum="7C6BF16B6D42704E" modified="2020-04-22" version="1">MASFLQSRPVCSAVCKQSTALPSYLSHSVTTSSRTCSSFPTLSSSRLINSQYTPLQRLNSRSGLPTQQSRTFLVQLNRQSQTLKETTSTSAPSVANLQLTNLPYFVRRTASNQLPVYLVTKAGGTKQQTKIQKTEGDVDTLRNDLAQYLGLESSGSSKSSDITINRLNGHIIIKGWRKPEILKFLQERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U280</accession>
    <name>A0A5N6U280_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_127754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U280"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="8">
        <location>
            <begin position="88"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="543" mass="61199" checksum="26609A55F6335809" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2F6</accession>
    <name>A0A5N6U2F6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_137642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2F6"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="205"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="382"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="922"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152700.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="107427" checksum="BBF9739184267461" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2P1</accession>
    <name>A0A5N6U2P1_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="129" mass="15003" checksum="B384C4D4A895813A" modified="2020-04-22" version="1">MARLFEHRIFPTGVAFATRALREAFEVDHDEPHRSVYILGAAQWILWYGQTLSSLVWQRIHSDARPEFPVTAEHSLDRFTTEKWKLWKTRFREYQGNDECAKVAQKAACLMDALEKNLTSPHVDQPSTT</sequence>
</entry>
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    <accession>A0A5N6U2R6</accession>
    <name>A0A5N6U2R6_ASPAV</name>
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        <name evidence="9" type="ORF">BDV25DRAFT_150428</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8152820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
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        </location>
    </feature>
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        </location>
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            <begin position="237"/>
            <end position="257"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="30521" checksum="198716494FD4E2B9" modified="2020-04-22" version="1">MFLNMPSLSRRALKPYAAEFLGTALLIVIGDGVVAQCLLSDYQYGTWLSINIAWAAAVAISGYLSNPSPAINPAVTICTALVRPTPGQWKKLPGTLFAQFLGGFVGAALVYTNYRSAIQAWDPEYTIPGGSILSPQGHHSAGIFSTYPAATLMSNWEAAFSEFLGSAVLMFGSLSIADPANAVRFHSTQLSMFLLLAAIGAALGWQTGYAINPARDFGPRLFSAIIYGREVFTAANYYFVVPIFAPIAGCLVGATVYDSVLYEGDGSHIKDALDKVGDRDGLLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2X3</accession>
    <name>A0A5N6U2X3_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
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    </feature>
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        <location>
            <begin position="674"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="765" mass="87713" checksum="3748D293C314D227" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U387</accession>
    <name>A0A5N6U387_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_137276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U387"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="33"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="535" mass="56767" checksum="642985592E8FCB38" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3D9</accession>
    <name>A0A5N6U3D9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_169720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3D9"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="47064" checksum="29AA55F1F1FBFCC1" modified="2020-04-22" version="1">MDRKADLEWMPLRPEPVQWRSRQRSLAYSVTLTLVALLLTFTLRLDFVPSFLARDSVLQTPLEQVLTRVPLTDGHNDFAIWTRAFYQNHIYQDNFTDHNELYGQVDFPRLRKGRLGAQFWSVYVECARHPNEPGSEYEIVRDTFQQIDLVHRMIDHFPDFLVPASSVADIHHNFYHSPGRISSLLGVEGLHQIGGSASVLRMYHELGVRYASLTHTCHNEYADSEAPAEPRHGGLSAAGEAIVAEMNRMGMVVDLSHTSLDTQRAVFKVSRAPVMYSHSSAYALCPHSRNVPDDLLQMLKESDGIVMISLYPEYTNCQDADAASLAEVAGHVQYVGNLIGYRHVGLGSDFDGMSHGPKGLEDVSKYPDLLQELLDRGVSVDDLVGVTGGNVLRVLGAVERVAESMRDTLPLEDDVKPFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3G5</accession>
    <name>A0A5N6U3G5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_127385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3G5"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52981" checksum="E47729E31C3433CF" modified="2020-04-22" version="1">MSPTHSSKPSIATSVDTYLSNSTTSDWKRYSANVDLEDQQPPRKCFASWRYLLLTIYRRLFTLIYCANAVAFVIIMVRSRDKLHAFVNAAAVNLLICGMARHPLVVNAIFVSICRTPLSTPLWLRKMAAKAYHYGGVHSGCGVASFLWYVGLVALISREYWILPGSETVSLPVVILAYVLLADLMAIIVVAHPTFRIKLHDYFELTHRFGAWLAVALFLTLLVVFSDQGRRAEGVILGQYLIKFPAFWIVLAIVVIIVHPWLLLRRVKVWPEYLSPHAARLHLDHTSTAFGKVIALSKHPLRTWHSFATFPDPDGKSFSCIVSKAGDWTTRCIDQQPTYLWKRGTLMYGFIHVMRVFRRAVVIATGSGIGPCLSWLSEKNRPPLRVLWQTRNPSRTYGPDVLNLVRQLDPSPLIIDTNSSGRVDMVPMARELVREFDAEAVCVISNAVLTKKIVFELEASGIPAFGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3J0</accession>
    <name>A0A5N6U3J0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_150430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3J0"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="470" mass="51864" checksum="ED2F63922CB411DB" modified="2020-04-22" version="1">MLSPYHESPGFGIQNGIPRDCELSQAHILHRHAERYPESDWFDGGGMESFSDKLNKYIQNHGEVGTGLAFLRDWRYLLGRDVLLPSGAATEMSSGADIWSSYGRMLYRAPASQSGWEPGLNKYPNGTERSKPVFRTTDKQRVRVSAEWWLNGFFGLGSGNDDYELVVIPEGGGLNNTLAAEHSCPGDLKEETEDAARFLQKVTAKALPRLSRHLPDFSLTSPDILAMMNLCPYETAALGRSSFCDLFTEQEWLDYAYHLDMRLYGASGFGSPTGRAQGIGYVLELAARLEGKLPSLGDTSINTTYDTDPARFPIHQPLYMDMTHDKIIIGTLAALGLQYFNYGPKGLPVDVGHAVPRTFHLNRITPFGAHLVSEVWTCPGNADLNVLDKMLYTNPDLSNSNNTTEYIRFVLNGAPVPMTGLVGCEHAVNGFCNVSDFVNAVPILKTEAMYQEACYGNYTPGHQVGNGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4C1</accession>
    <name>A0A5N6U4C1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_24036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4C1"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="217" mass="24098" checksum="F6DAAD156A53979F" modified="2020-04-22" version="1">MTSNSFRDSVNSLGWSRRDPDVPVRTNASSGSFLTRLQSWNPFGQGEGYVQLPTHEAPGAPLPAATRREEEDSFFALSRWDRMLIFIACNAGAAVCFFICFFLFPALSFKPRKFAILWSVGSLLFLLSWAVLMGPLVYARHLISGSRLPFTAAYFGSIALTLYFAVGLHNTFLTLLSSIFQLAALVWYLVSYFPMGSTGLQFMGRFGAQRVGAWMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4C2</accession>
    <name>A0A5N6U4C2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_27655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4C2"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="512" mass="55047" checksum="7A4AE95E0CA1C305" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4G1</accession>
    <name>A0A5N6U4G1_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Ribosome biogenesis ABC transporter Arb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_149306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4G1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
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        </location>
    </feature>
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        <location>
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            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="606" mass="67967" checksum="DFA25A53A84AB508" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U500</accession>
    <name>A0A5N6U500_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_136616</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="174" mass="19048" checksum="4F42D72473D79A55" modified="2020-04-22" version="1">MPSNQSIQTALSLIEQNPPQILNLTVGPHQEVKPGQYIPRAEAQSAPQISFPVASSSATYMVVALDIDAPFPSFNVLGPILHWIQPGLKARDGRLEITEPSVVNYIGPAPPPGSSPHRYLFFLYEQPSNFEGKAHAPPDGQNLRIWSRVRYSLDDWGKTAGLGPVLAVNYFCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5E5</accession>
    <name>A0A5N6U5E5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative MFS maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_168302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8153792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5E5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="30"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="500" mass="56063" checksum="D9EE2D7384276CDB" modified="2020-04-22" version="1">MQKNVREATEAEQQMGFTEALRLYPAAVAWSVGLSTAVIMEGYSLMLLSNLYAQPQFNRRYGDLQSDGSYVISAPWRSGLSNGALCGELLGLFLTGVAQDRYGYRKTIFAALFMVTGFLFILFFAQNLPMLLVGEILCGIPWGTFQTITTAYASEVCPVALRAYLTTYVNLCWVIGQLIVSGVLRGVLDRDDQWAYRIPFAIQWIWPVPLMVMCVYAPESPWWSVRKGRFEEAKRNLARLTQGSEDAIDATLALMQHTNELEELSTAGTSYRDCFRGINLRRTEIVCLTWLIQAICGAKFMGYSTVFYVAAGVPQSWSFNLTLIQYAIGFVRTVLSWFLMAHVGRRTLYLYGTLLLCCLLVIIGSVSLAPRSNHVAHWADAILLTVFIFCYDLTVGPVCYSLISELSSTRLRAKTVVLARNLYNVAGIVNWGAKSIFFWGGICFCCSLWIFFRLPEPKGRTYGELDILFAQGVSARKFSCTMVDITDSTLSREDKLTAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5W9</accession>
    <name>A0A5N6U5W9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_167745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5W9"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="179"/>
        </location>
    </feature>
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        <location>
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            <end position="211"/>
        </location>
    </feature>
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            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="57441" checksum="D44DF1AFFBA24072" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U636</accession>
    <name>A0A5N6U636_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U636"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27274" checksum="CDC99389259E62E5" modified="2020-04-22" version="1">MTTQPGRGWFGSKWLKQTIHFADLPSSWRIVQKLQEQETIFLQDDYRSSGLYSESIGIFLCEEIGTSTPAIMKIRMQVPNTVDDPSSSRTFIQPPEKDICGRTSQEIDALMALTKAECSCTPKYFASKHTNQTPDDWVPGGFLDYIVMEKMEGVTLSEEYLRELSQREQQELRNAFKSSYLECQERRFYHLDASLSNLIWNKQKMKCYIVDWEARVRKAYSWDDEEYLRWGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U665</accession>
    <name>A0A5N6U665_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_1431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U665"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF0">
        <property type="entry name" value="FI21273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="3"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="447" mass="49714" checksum="842ACEFF96264E1C" modified="2020-04-22" version="1">MHPLKVYTRWRPLTEQETPLSTTTIPHNPNYSITLSNTNPNPNTNPKPWKSDPTYAQIFAPTSTNQDIYETVVLPTLPDILKGNTSNILAYGHSGTGKTHTIFGYDFAHSPELGICLSTAKDLLDTLHALNHSSSDPLSKKREDKLGLGVRMYELRQKTAFDLLNSRRPCHVREGYDGRTHIRGETEVLDEGKVRVRPVVAKACWGFEEVLETVRCGLGRRATGSSGVHDLSSRTHAVVELEIVSWSLLQAREGVVERESELVPVAKAATDVYLREHMRALVLGEGGEYVVDPGVRVDLGKIEEAEGRKRVFEGYVKEAEERVRRVFEGGFEGLGGRVVFVDLAGSEYFDRSVRVRQTPQEVREGRQINSDLLALKEVIRARALKMARIPFRASPLTMVLREHFVPAERESYSAMILTVSSAAEQVDATLNTLKYGNLVGVAGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6V7</accession>
    <name>A0A5N6U6V7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_167850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6V7"/>
    <dbReference type="OrthoDB" id="5350472at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="313" mass="35421" checksum="760C9991F07AA054" modified="2020-04-22" version="1">MVQPREQILQAFGGQVNMRIAFQFSRDEIKQFLGNVRANPVAFGAAGTDIPAIQALCQDIARLWAFDGTHYSDPSLRPEQHILRVLHPEWPREYISKFRLGRHLFKDVNFWSLPDLLGLVLNLLGPAPAGATRRNFFLPLIAMFGKWCQKLCVEYPPVVLQCTWTTGGNGEYFLGASMSGYNVDKVETGSWLAVLNRARFSVISTERFRLSGWSQAWSPSIRRRRRDGRPFGRCAETYPLRFLLRDTADKSAIHGLGLSARVLWSTHAYDDRLAGPIWEGTWNPCSNCMALIENMEGLVANFNRYNGRRGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Z6</accession>
    <name>A0A5N6U6Z6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_135859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Z6"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154425.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="726" mass="81758" checksum="659A2CE453E5337A" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <location>
            <begin position="48"/>
            <end position="68"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="11201" checksum="6FDBE2CA8C24A9FB" modified="2020-04-22" version="1">MTTRTPRPPTGMPTPIPRPPRPPATEAHPPTPPHLPIQTLRTRLRLPTPAPRPTQAPPTAPPPTPTPRPTVVRLPTALRLTAVTLPAPITAVTLMHPRPPVNVQ</sequence>
</entry>
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                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7R1</accession>
    <name>A0A5N6U7R1_ASPAV</name>
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            <fullName evidence="4">Integral membrane protein</fullName>
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        <name evidence="2" type="ORF">BDV25DRAFT_135586</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="209"/>
        </location>
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        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29010" checksum="D3F8252D5E0F2CF5" modified="2020-04-22" version="1">MPPKQQLKALAENINSHPLYTKTCNPQTWQYCSILCGPLWGLTFLLGLIAMRSFPPMPPSWDADRVHAHYKAYHTGTEAAAALFIFTGGFFLPWGAVISRQISRIPNVDPILPQLQLASAAAGVFSFIFSGIFLGVITFRDRGPQLTLLLSDLFWISTLIQWPTLWMQSWTFAWAVFADCSARPMFPKLVAWVNVVTPIVFACATGVHTQFHGPYAWNGVFAFWMALGFLGLEIGLDALSMLKNVREEGRVQEVVEVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7U6</accession>
    <name>A0A5N6U7U6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_135585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7U6"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="287"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="741" mass="81971" checksum="18AC06550F87E9F4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7W8</accession>
    <name>A0A5N6U7W8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_135934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7W8"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="154" mass="17143" checksum="5E94EEC7EA6E74C5" modified="2020-04-22" version="1">MSLASGVSITDECITKFNEFRMSGGKGDKIKFIIFKISDNKKEVVIDDVSHDTDYEVFRTKLDEARDSKGNPAPRYAVYDVEYDLGAGEGTRSKIIFISWVPSETPTLWSMIYASTRENLKNALNIHTSIHADDKSDIEWKTVLAEASGGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8M6</accession>
    <name>A0A5N6U8M6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_135306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8M6"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="395" mass="44206" checksum="A975A4F5C1239A73" modified="2020-04-22" version="1">MSETTTNPQPQNASPLNLNPPPPDSAYICPSPTLPKDLWTPPAEPYFLYDTLTDPTVLRELLVLKEEPQLRPAYILGYEIKLWGQCPALLDKRGSIVKGFVYDVRTEEDAAKLAAYETKSYREVPCWIRYMDGEKPVEDLGRTFLFAGDFGELREGVFDLGVFLGGRGRGRGRDCVVEKVGERLDTYTSISPQMLQAILALKDLLASGYELSHIIGGDSAGGHLCLSLLSHLHHRRPFEDSVNCHVDRNTGVRGCFLVSPLCSYNFNTPSYKRWFSADTLGQRVSKWGKCLVNGSPWHHEISAGKGWGMALDVPERWWEGLNVVDRILVVGRYEEAFSDHVQQLGATLQRCSKGEVALHMFNEAHDGPLMDFAAGRPPSETTKTITHFMVSSFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8W4</accession>
    <name>A0A5N6U8W4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8W4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="74" mass="8442" checksum="A84FC846DE2A9510" modified="2020-04-22" version="1">MGSCLYCMIEAVTRVDIGFGSFGLFFFCYVLSCSSSSGLRRLRGGSLGVRVRFRFRYKMKMSVDSRWNTAIWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8X5</accession>
    <name>A0A5N6U8X5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_135393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8X5"/>
    <dbReference type="OrthoDB" id="4502805at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="133"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="527" mass="59072" checksum="4C27D7AD31477200" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U962</accession>
    <name>A0A5N6U962_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_135159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U962"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8155116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="381" mass="40064" checksum="83B714131DF32C7F" modified="2020-04-22" version="1">METVTDALVMRNFGEDLRVERVVAKGPAPDEVLVEIAATGICHSDLLCMSGNLPFPTPTILGHEAAGTVAAVGTGLLGSYSVGDQVILTFDSCGDCNSCKTDHPAYCHDFTSRNAPSDLSDDGKPRLHMATPDASPVWGKFFGQSSFARYALVSSRSIINITASCGLALPREELQYLAPLGCGVQTGFGSVMNSLGVTAGSSLAVFGAGAVGLSAIMAAKAVGASIIIAIDLVESRLALAKELGATHVLLNSGTTLAQDVKDIAPVDRGVRFAIDTTGVSSVIEAMVQSLGLMGKALSVGMAYANPELKIDINQMIMSGQSYLGCIEGDSVPDKIIPRLVEEYRNGRLPVDKMARMYPYTECNRAIADMRSGKTVKPILVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD69</accession>
    <name>A0A5N6TD69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_167410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742661">
        <property type="protein sequence ID" value="KAE8144206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD69"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="84" mass="9315" checksum="DBEC03B7738D2EDA" modified="2020-04-22" version="1">MSQTFTSAEVASHNNADKGLYIIIDNTVYDVTNFVDEHPGGAKILKRVAGKDASKQFWKVFLDNPPSPPFSLSLQFRPVALYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD73</accession>
    <name>A0A5N6TD73_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_167302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD73"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="362" mass="40087" checksum="64A41252B2A68C90" modified="2020-04-22" version="1">MDTVLSNTLLPRGGGDGGARGEQALVVTAVLTGISIVIVGMRMVARVMFLKMTGREDYTILYSLVLAIVYLALVAAQVHFGLGKHNDSLSSYELKQQLKRLWVAIPIYNASLAFTKFSILFQYLRIFPDPKFRITCHIVMGIVAAYTTWAVVSGYVNCVPVAKFWDRDIPGSCLSFEAVWFFNASMNIATDLTLLVLPMPLLSQLQLPRLQKVALMGVFAIGGLVVITSVLRLSSLRSVANDTDTSYSNVAAAYWTAAECNVAIICACLPFLRPLISRFFPKLLSTNNYTRNPTMTATRSRTNRIELRSQDRDYGLYTIDIQGGDQKDKTLAGIEVTTEMYQSTETSKNDESTSQRRLVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDT4</accession>
    <name>A0A5N6TDT4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_145605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742516">
        <property type="protein sequence ID" value="KAE8144457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1751210at2759"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="403"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="707" mass="77311" checksum="DD4AC8DA1E4F36F8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE11</accession>
    <name>A0A5N6TE11_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_90026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742475">
        <property type="protein sequence ID" value="KAE8144613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE11"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="59580" checksum="5417D9B1CFB24253" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TES0</accession>
    <name>A0A5N6TES0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_87036</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="12"/>
    <dbReference type="EMBL" id="ML742443">
        <property type="protein sequence ID" value="KAE8144750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TES0"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="17">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="18">
        <location>
            <begin position="297"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8144750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="419" mass="43566" checksum="7FD7F5421840730A" modified="2020-04-22" version="1">MSSAQQRLTQVASHFTPSGKKGAAALTEKHPDDIVVTCALRSALTKGGKGGFKDTAGADILAGVFKGVIEKSGIDPNAVEDVAVGSVLAPGGGATEFRAAALVAGFPETTAVKSLNRQCSSGLQAIVDIANAIKSGMIEVGIGAGVESMSSQYGPGAVTEFSDLLENHQESANCKVPMGVLSEQMAKDRKISRAAQDAFAASSYQKAVKAQKAGLFNEEIIPLEVKWTDPKSGEEKTITVKADDGIRDGITPESLGKIRPAFAKDGSIHAGNASQISDGAAAVLLMKRSTAERLGQKIIGKYVAASVVGVKPLLMGIGPWKAIPVALEKAGITKDDVDIYEINEAFASQCVWCVNELGLPQEKINPKGGAIAFGHPLGCTGSRQISTLLTELKRTDKKIGVTSMCVGTGMGMAAVWVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF90</accession>
    <name>A0A5N6TF90_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_134141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742397">
        <property type="protein sequence ID" value="KAE8145033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF90"/>
    <dbReference type="ESTHER" id="9euro-a0a5n6tf90">
        <property type="family name" value="Thiohydrolase"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="307" mass="34647" checksum="C7B684D387470C96" modified="2020-04-22" version="1">MPTIENVEFPTVDGLTLRGRLYAASQRGPAIILNPGFNLVKEVYVPEMAECFQRANITALIYDFRNYGDSDGLPRNELDPSKQADDYSDAVTFLAGLPIVNPSQIALWGVSYSGSVAVAAAALDKRVKMVFAVCPMTYEPIEQDNLEKKKEYRKLLMKCNRDKVAQMRGNPPARMPMMDSTGRSSFGNAYYEDGVYETVMRLKETIAPNFEPEFTVRTMINMLKWDPMNMLRFLDVPVWWMVPQSDSVSRADVQMEIFESIPGPKRLYGVEGKGHVGSLMGEQLPEMVDAQLSFFRDVLEGKFGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFA5</accession>
    <name>A0A5N6TFA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_78401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742394">
        <property type="protein sequence ID" value="KAE8145055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFA5"/>
    <dbReference type="OrthoDB" id="3786931at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="455" mass="51466" checksum="980CB83412B1BE0E" modified="2020-04-22" version="1">MCLEAAPLSPAVKYPQSIADLSKSDLRLLTAMLIEENLNEPGSPNGGDEHIISAIKKLPPSLRKRRLIFTNRRPTATLCHSHGKLNAYVIRHVFELLRYEVTTRMECMYWYHERVHADLRCVVEGLEEMHLIWTPSRRSIFRGPVRYQQNQCHACILARVVKEPRFLILLRTAILSRILVKRNYHVPRLLPFVDEAVRCHESAREQIHYLSGMWAESMKHQRNKALCKLQSSKPIATVPLVIDPESLVSSRRECQRQVHENPDLALQAAVKKGESDADTLSGIIEVYKFGIPSPTPASSPTHHSQSYFLPPTRTQGSSIYSSSNSGTTLTRTFNALTIRPLTVSKASKQPIGKGVTDQMPGRDEPPAQGSEELAAEYQKLLDPHLHYTSDEHEGPIPGSAYTNEPTMEHGSPETTWAMMIFEEYEGPIPKRLAHADVPAREHESCETNWDMFKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFQ4</accession>
    <name>A0A5N6TFQ4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_134035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742380">
        <property type="protein sequence ID" value="KAE8145146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFQ4"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="244" mass="26946" checksum="563C964ACFDC6AF0" modified="2020-04-22" version="1">MSGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVIDQQSCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSITSRASFSRIQKFYNQIKMVKESANSGSPTGASYLASPINAPSGPPLPVPVMLVGNKSDKAVERAVSAQEGQALAKDLGCEFVEASAKNCINVEKAFYDVVRMLRQQRQQQQGGRSQDRRPTGLGPMRDRDAGPEYPKSFRTDRGGRHRGSLKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFQ8</accession>
    <name>A0A5N6TFQ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_134036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742380">
        <property type="protein sequence ID" value="KAE8145147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFQ8"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="9"/>
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        </location>
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            <end position="485"/>
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            <begin position="552"/>
            <end position="636"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145147.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="75847" checksum="E33239AB41A1DEFE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFR8</accession>
    <name>A0A5N6TFR8_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_165149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8145215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="97" mass="10891" checksum="B628001DA76FF802" modified="2020-04-22" version="1">MSFGVRRQINLSIRSRSSFTLTQPARSTPRPHYFRQQQQHHPYSSTPPNSSSPYNRSQFKIAPFIAIFALGSGSYALLVKSRTGIHKPKADSQSPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFV3</accession>
    <name>A0A5N6TFV3_ASPAV</name>
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        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_165621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="10">
        <location>
            <begin position="623"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1849"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1920"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1962"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1979"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2052"/>
            <end position="2061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2117" mass="235991" checksum="CCFBA9377DF1FA9D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG83</accession>
    <name>A0A5N6TG83_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_164772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742350">
        <property type="protein sequence ID" value="KAE8145394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG83"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="307" mass="33399" checksum="886C9D3DE1B28B3C" modified="2020-04-22" version="1">MAEFNGRRAPNFSQYLEDLNAIPSPYDQAVQQQQQQQGSFNLDAELSLFTNAEFFDFDNFGAENFADLNLPAFDSAENGSSKKENNQPTRQNPDMEFLDLLSGGFGNVPEYSAAGFNSTNTHSQSTSLQNAQYSSVPQIPHGSVNASSSPNESAATSSPSPSTPSQAPAPATSSTATAPGPKRKNTQKPTPMSVEEAARVAAEEDKRRRNTAASARFRVKKKMREQALEKTVKETTDKNTALEARVTALELENQWLKNLITEKNGQSSDEGKKSENDIADMFKKFLASQKADSQRNSAESKLGVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG86</accession>
    <name>A0A5N6TG86_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_164867</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742355">
        <property type="protein sequence ID" value="KAE8145353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG86"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="108"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8145353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="562" mass="63024" checksum="03E6522941E16E19" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGI4</accession>
    <name>A0A5N6TGI4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742346">
        <property type="protein sequence ID" value="KAE8145436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGI4"/>
    <dbReference type="OrthoDB" id="4226885at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="603" mass="66209" checksum="F7093F71B8FA1070" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGJ8</accession>
    <name>A0A5N6TGJ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_164535</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="ML742339">
        <property type="protein sequence ID" value="KAE8145505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGJ8"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8145505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="640" mass="70633" checksum="E2B4FE070BEA1AF8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGU4</accession>
    <name>A0A5N6TGU4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_68722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742334">
        <property type="protein sequence ID" value="KAE8145552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGU4"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="728"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
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        <location>
            <begin position="660"/>
            <end position="730"/>
        </location>
    </feature>
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        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
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            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145552.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="843" mass="92564" checksum="5E11E0517E4DA4D0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGY0</accession>
    <name>A0A5N6TGY0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">Dihydrodipicolinate synthetase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_164224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DapA-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="147"/>
        </location>
    </feature>
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        <location>
            <position position="176"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36141" checksum="77134EDC0913FBF8" modified="2020-04-22" version="1">MASRTPLRPGVYAPTMTFFNPDTEDVDVPTIRRHAVRLAKAGLVGLVTMGSNGEAVHLTREERKTVIRETRSALVEAGFQNVPVITGASEQSIRGTIDLCKESAEAGAEYALIVPPSYYRYAVGNDETLYDYFTSVADGSPIPLILYNYPGAVSGIDMDSDLIIRISQHPNIVGTKFTCANTGKLTRVATALNAIRPESPLAPQRKNPSTKKAENHPYVAFGGIADFSLQTLVSGGSAILAGGANVIPRLCVHIFNLWSAGRFTEAMEAQQLLSSADWVLTKTAIPGTKGAIQSYYGYGGYPRRPLGRLSAEQTQTVADKIKEAMDFEQTLPDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH94</accession>
    <name>A0A5N6TH94_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742340">
        <property type="protein sequence ID" value="KAE8145499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH94"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25021" checksum="3354A943CD7CFEA9" modified="2020-04-22" version="1">MDSTTQIDRATMIELPGTSSGSNADGHDVFEWYPHYQNCQRYFLDHAQHSTTVQALSAFLNIRLPFQRQPHPVFNSSSENTTTDNQPLPTSSSTSSSPPPVSLIPYIRRLVATGMDFPGVLHGYFGDDWGSGIGFLHEQERRNYLFAAKSGGWACVKKDYDMPPLETIPFLRPLQGPLESEIEAAERSWSEWLAMEDWMVGPRAPDILRDSSSQVSRPRSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THK4</accession>
    <name>A0A5N6THK4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742306">
        <property type="protein sequence ID" value="KAE8145864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THK4"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="360"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="713" mass="78528" checksum="8D1F555C8397811F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY1</accession>
    <name>A0A5N6THY1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742299">
        <property type="protein sequence ID" value="KAE8145946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THY1"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="273" mass="30305" checksum="FFCE7FF221E16AAB" modified="2020-04-22" version="1">MLQQRLIAPFRVLERAIGPTLRSTQSIPRSSPSIIPRSIISASAPAFSNRLFPLSQVRHASHASQGTANRHSRDPAGKRLGAKRSGGEYVVPGCIIFRQRGTKWFPGENCAMGRDHTIYATEAGYVRYYLNPELHSERKYIGVCFEKDGKLPTPRNAPSRRKLNRVAVPRIETVPAPIAGQSDLVASIEDGVKVSSVEAVNAESGSQLRPGYMYREANWQIGRAAEKAGITAKQYSRNNRWLAWRKRKARAERAAQMKSLKNKKKASKGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI44</accession>
    <name>A0A5N6TI44_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">A49-like RNA polymerase I associated factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742293">
        <property type="protein sequence ID" value="KAE8146015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI44"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="53066" checksum="FC421F6096324270" modified="2020-04-22" version="1">MPSDKVEKKRKRASNGHERPSKKPALELRDLPPLAASVVDDDSELAPVIVTTPGVNAPRSLRLKPYLKDRAASSTSTRNKGIVSSELLLQSSEHPKMDFVGREANDDADSQLKHYIAVVDPEKKSWQFVEVRKVTLRGAVRSTKRAVEDESEAESEEEEMKTMRAQKTELTNSFGTKQARKAAQSMAENAQLSNAPAGAASAAESAILSSMPLDTATDIATKAASVQAQVQANKPIPQANLDASHPSDVYPLDVLVPGGLSTLQQLPGITEWQETVHSGQAVSTTSRYVSRRVEAVVNSTNTTQLQVLRFIFLLLELARGLRPGKERGSKRLPPREELRRILSSPTGAKNDTTEALPVPVIDAVRRKFAPQGSQITKNDITFIHTTICALSLHIPPQPAKDGGSSSQGGNSPNELATDPSDLRDDLHLENPVITQYFRELGCRIDKIREAEFAKWNIKGGKAEAAARRVARLKVPLVFPKVSRGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI87</accession>
    <name>A0A5N6TI87_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_170058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742291">
        <property type="protein sequence ID" value="KAE8146037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI87"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="186" mass="20188" checksum="006F05535DB05D8F" modified="2020-04-22" version="1">MTTQPLNPVPPPYWAVALNAPAPPLAKAAAKIPDPPGFSRATGGKSRAQQQASTAASKPVETDTLKVKKAWEIAMAPSKQIPMNAIMMYMSGNSLQIFSIMMVFMLFKGPIQGLISTNTVFAKFESEGTRAKLLGVKAVYVLMQFVLLALGVWKVNAMGLLPTTSSDWLAWESERQPLERAYFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIA9</accession>
    <name>A0A5N6TIA9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_56839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742290">
        <property type="protein sequence ID" value="KAE8146057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIA9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="136" mass="15579" checksum="E4738575AA21DDB9" modified="2020-04-22" version="1">MHLPPVRCLKGSAPLAHRTGRIKGGRSSERLSVCEALPIIGHCSHAGDVYHRFGQWKPKFQRIEPLHVTPSGSFPSDPLDTTALWTCNGPPISQRPYLDPFLVFILFYFILFYFILLILAPLRFSFCNWVNRHFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIP3</accession>
    <name>A0A5N6TIP3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_162967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742280">
        <property type="protein sequence ID" value="KAE8146197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIP3"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="65" mass="7545" checksum="F1A685F3BF55F711" modified="2020-04-22" version="1">MAKSKNASQHHNSQKAHRNGIKKPKTHRYPSLKGVDPKFRRNHRHALHGTMKALKERKEGKREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ11</accession>
    <name>A0A5N6TJ11_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_53319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742272">
        <property type="protein sequence ID" value="KAE8146307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ11"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="467" mass="50908" checksum="2213A04C3D05A29A" modified="2020-04-22" version="1">MRDSSPPSLSEYPTSPPQNDGKSKWTPSTFIRSAERSHSRIPGIRKIPFRALAVILFVALINILVWIAAAIVLRYYPSLVSNAVLAYTLGLRHAFDADHISAIDLMTRRLLATGQKPVTVGTFFSLGHSTIVIITSIVVAATAAAVSSRFDSFSTVGGIIGTSVSAAFLILLGLMNFYILYKLYRQMQKVLDLPEGQEDEAWKIEGGGILFNVLKRMFKLIDRPWKMYPLGILFGLGFDTSSEIALLGISSIEAARGTDFWVILIFPILFTAGMCLLDTTDGALMLSLYVQPAANFLPPKEDSSSDAPLIGEDHEIQAPQNHRDPIAFLYYSIVLTCLTVVVAIVIGVIQLLTLVLNVAEPTGRFWDGVQTAGDYYDAIGGGICGCFIIIGGLSVLVYKPWRRWVARRHGKTVVTDEERYRDEVPAARPETPILNDERGGAPGASYGSVNKKAASQVAVEPVDGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ36</accession>
    <name>A0A5N6TJ36_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_132977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ36"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="367" mass="41795" checksum="48140D20C175F4E6" modified="2020-04-22" version="1">MALRQASQTLPLSVRSSIARTRVNYVQLGRSGLRVSNPILGCMGFGDPKWLGWTLAKEQAMHILNAAYERGVNTWDTANAYSNGTSERIIGEALRQNRIQRRKVVIMTKCYRPIADDDDPATFVPLLDKELSQSKDYVNQYGLSRRAIIESVNGSLERLRTDYIDLLQIHRFDSTVPPEEIMETLHDLIKSGKVRYIGASSMWAYQFSILQHTAERNGWTKFISMQNHYNLLYREEEREMNKFCKETNVGLIPWSPLAMGRLARPLTEDCSTLRSTVDRIGKRFPIGESSEDQEIIRRVHSIAEKRSWSASNVALAWINNRVTAPVIGVSSVGKLDACLEARGKVLTEEEQRFLEEPYVPKAVYGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJG7</accession>
    <name>A0A5N6TJG7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_54338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="ML742277">
        <property type="protein sequence ID" value="KAE8146231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJG7"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="431" mass="47332" checksum="2BF82DB2DCB02FFA" modified="2020-04-22" version="1">MSDLDRAIAQLRACRLIPESQVRELCYKARELLIEEGNVVCVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGALVLGASSELEPSGPSMNDNTQTTMPLDDAELETEILNSKGEVTGSTYRPRQRTLSDSSTDTRNISPPRDISATPGQTPLRTGAPGTGASGSGGGSYSSRTGSVLCVHGGLSPLIDTVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGGDIVKQFNYRNDLSLIARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVASILELGEDTSNGGTVTRSNGDYGRSNGIISTDKPGVRSPGRRYRVFEAAAQDTRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJZ5</accession>
    <name>A0A5N6TJZ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_46515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742247">
        <property type="protein sequence ID" value="KAE8146688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJZ5"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7851" checksum="32F2527ADE971E16" modified="2020-04-22" version="1">MNVCIGGMLESHPEAGQTPPFKGSVIVVRAESENAAREVLKGDVYARSGVWDLNAVQIIPFMCAVRVGDRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK32</accession>
    <name>A0A5N6TK32_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742260">
        <property type="protein sequence ID" value="KAE8146469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK32"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="55420" checksum="4260D709272ED195" modified="2020-04-22" version="1">MDTLSDLQLNGLIVIGIIGLWFALDKLLNNFSLSRERHCNRVTPTSATPPPTISEKKSSGYAGVLPPQSRQALAVLLRSAVTLKEIDEKEVLQHILPMTTDYTTCRDEAYTPTGISIVEVQELGNFPDYAQLSGVPLPTEYSQFDINKALPRPYRPFRWGYHQTMSLTKLETDWWIELENTYENRIAQRKDLYAKHGDAVLGWLPGSELACKELMEMVLQFICARYPQYFTLKDSCILHNKILGTEQDVRSKHPLEILLDNVPEDFGVMQRDEKTGCYFLRAGVICSSLGWNVRDKIGLQLHEIHGPIPDYKEKMQFSMDRFFTKMSADKPIQRGSWGLEVGQPLYMPRGDPHERFRTYQEPKLQLQDCHLRVDWQTLRRLPLSGAIIFNFKALFTPVAEFRDEAGIPALVAKILKEGKKSLMDYKNTWHVEHVVLPKLEEWAKEQEENGIVPRNWEIATLGESPWYKNWESKWHHQQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK47</accession>
    <name>A0A5N6TK47_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_132689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742245">
        <property type="protein sequence ID" value="KAE8146734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK47"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="558" mass="63095" checksum="61F8642243C29FA5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKH6</accession>
    <name>A0A5N6TKH6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MIND kinetochore complex component Mtw1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_43859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKH6"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="337" mass="36900" checksum="B7BDE20D66424F9A" modified="2020-04-22" version="1">MNDATTSLLTEHFSYTPLSLVDDVINSINNLIYQAISSLEAGLLSTPPERLGFSHATNGSTIPDTDEDGNVVYPEAKLEIENGLHQLETLLEATVDKAFDKFEIIVLRNSFRVDDDLLNWVRLKHYEGLDFSPSPDAPTAESILALRKELQETKKLNRALKQETARNDAVIAQLRTILSATQPADGAKDTKKEADTETPASAGNKQDLDLSFLTDSPAARQLRVGAAMGSNIQHTPLTTNTTFITSQLPALQALLKQLRPKLATLPKSNETAGTDPKREERKEYIESRIRLHLERTGQLGVGSDGNPVVAGRKIDVSEAQALEAVTGMLTQDDKMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKN1</accession>
    <name>A0A5N6TKN1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_161679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742240">
        <property type="protein sequence ID" value="KAE8146830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKN1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="9">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="405" mass="44266" checksum="489C6F0059F6334C" modified="2020-04-22" version="1">MDFFPFTRAGIGRRTLGICLLLIVVVLWTASNFLASTIFADNTYSKPFFVTYVNTSLFVLPLFSILAGRVWRLWRSGKLSQVHSFQSLLRHIDSHDPDADNHHSDEAGDPETWNTASLEPVAKEQESSSKLGLRATAKLSLQFCMLWFLANYFAMACLQYTTVGSTTILTSTSGVWTLIFGALIRVEKFTVRKLLGVVASLIGIILISRVDLSASETPPTDDGNSGGFPQKSTAEIALGDAMAGFSAVMYGVYTIVLKKQVGDESRVNMQLFFGLVGLINMFLLWPGFLIFHFTGLEKFSLPDTGKIWTIILVNSFSSLLSDICWAYAMLLTTPLVVTVGLSLTIPLSLVGQIVLQGVTSSPLYWVGAAIVFLSFLVVNHESQEAAAKEAAAGDYDAVPGDEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL25</accession>
    <name>A0A5N6TL25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_161194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL25"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="372" mass="40524" checksum="C8912CCD5B732AA8" modified="2020-04-22" version="1">MASRPTVTIATAEGKPSGATQPLPAVFAAPIRPDIVQQVHTGMAKNKRQPYAVSEKAGEQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNQCRSGRMFAPTKVWRKWHQKLNLNQKRFATASALAASSVPALLFARGHRVANIPEVPLVVESKTFENAAIAKTKAAITLLKALGAGEELVKVNKSRKMRAGKGKLRNRRFRQRRGPLVVYNPEVDGKELVRAFRNIPGVETSPVFSLNLLQLAPGGHLGRFVVWTSSAFEALDQVYGTTSSPSALKKDYVLPQNLVANADLSRLINSSEIQSVLRAPKGEARTKRANVQKKNPLRNKQVMLRLNPYAAAFSKEKLGQKSVEHAKPEAPSKEFINTLYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL40</accession>
    <name>A0A5N6TL40_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_41007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL40"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787861" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="285" mass="30932" checksum="0664B28335BEE9C0" modified="2020-04-22" version="1">MKLSFLALAAIAPLVSAHYFFDTLIIDGKESTPNQYVRSNTRPAKYNPTKWVNTRDNMTPDMPDFRCNKGAFTFAGQTGTAEVKAGSKLAMKLGVGATMKHPGPALVYMSKAPSTAKTYQGDGDWFKIYEEGICDKNKDVKSDAWCAYGKDRVEFTVPADLPDGEYLIRSEHIGVHGAHAGEAEFYYECAQVKVVGGGKGTPGPTVKFPGAYKKNDPSFTYSVWGGYKDYPMPGPQVWTGASGSKSFSKVVDVDATGATSSQENAATIEGSFARREHARDFGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL79</accession>
    <name>A0A5N6TL79_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742225">
        <property type="protein sequence ID" value="KAE8147103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL79"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="179" mass="19783" checksum="DA574C96A1D006B4" modified="2020-04-22" version="1">MASGLILNPQTLLTTLPLASSTGTIVLATSELNFFSTFVHPELRKKSGSILPRYWEYLFPRALPLVLACNLTTIVSSACNIYFRSERRLLPVSKTTLYWLGLAGAIGHLCFVPSVAPPIKRMIEAKDEAVSEMKESHGNPLASLRRDIAALSSNCIKSISVDVIEKLQILRDVYFRMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLF2</accession>
    <name>A0A5N6TLF2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_169275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLF2"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="492" mass="54055" checksum="835868270F2CA222" modified="2020-04-22" version="1">MSDEEKLPQEDLASSKEIYPVTDLRKGVVGWDSQDDPSNPRNYPASRKWLQLATVSIITFISPFASSVFAPGVTFADREFGNTSTIRSSLAVTAYLFGYSSGPLLLSPLSEVCGRRFTLNTATSIFVVFQIGCALAPNLSALIVFRFLTGFGGSGCLTIGGGVISDLFEPERRGLALSFFSFGPLFAPVIGPICGGFIAQRAGWRWAFWVLVIVGGTLTGIVMVTNRETNPVILIHRKTKAMRKELNRPELRSCYVKEGQTRGPVSLLAKTFTRVIRLLATSPIVVILALYIASVYGCLYLLFTTITTVFQDQYGWSVEISGLSYFGLGLGFFVGQVVFAATSDWMVTRLKRRNNNIFEPEMRLPLCLPFALFVPVSFFWYGWSVQMKTHWIVPIIGLFPFAFGLIGVFGTLQAYVIDSYPQYAASGVGALTVTRSLFGALLPLAGPPMYQSLGYGWGNSLLGFITLAMVLVPILLNRVGANLRKRFVVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLN4</accession>
    <name>A0A5N6TLN4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_161327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8147001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLN4"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="386" mass="41646" checksum="31B342F803F93ED9" modified="2020-04-22" version="1">MSSQTPHPTLLIPGPIEFDDAVLQSMAHYAESHVGPGFVKTFGETLTLVRKLFQSTSPTAQPFVISGSGTLGWDVVASNLIEKGEDALVLHTGYFADSFATCLETYGANATQLKAPIGERPSFEEIEQALKEKSYKIITITHVDTSTGVLSDIKRVAEIVRRVSPDTLVVVDGVCSVGCEEIAFDAWDLDVVLTASQKAIGCPPGLSILMMSGRAIDRFKSRKTPPASYYSSIANWLPIMQNYENLKPSYFATPPTQLVHALHTTLSQITSRPLAERFAIHSQASDRVKAAVAEIGLKQLASKPEDQAHAMTAIWLPEGLAPPDVLPGLLKRGVIFAGGLHKEAATKYIRFGHMGVSVTDPARKDVDNAIAALKEVVIEAKQAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TML5</accession>
    <name>A0A5N6TML5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_159981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TML5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF199">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15915)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="340" mass="36673" checksum="A34598C36C0FC79F" modified="2020-04-22" version="1" fragment="single">MATPLAGTAIITGGYGSLGSAIAVAIAKAHPFVHLLLLARDIRSDSVKELRDKIRLIGPRSLEVAKIDLASFNSVVSFAENTVERVRSKEIPPVTLLINCAAVASYVADQVTRDGFDPVYQVNCIAPFLLTVSLLEAFRAGDGTPTGGAKVINIGCSAMSKGSLDYFNKHDFGNQQPGTPLTAKEGNMRFGSSKLIMSAAMYALRRSLVLNGSISLNIYTLDPGGLTGEGHLTENAPLSVRMAHQTRSGLRPFLRVFSKSAINNPSVPAKVISKVAFQKDTVEHWGREKYYILNNEYEAGSVIPVLRDSSKMEALMKKMMGQMEIGIKGMGSPQSRISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNB2</accession>
    <name>A0A5N6TNB2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_30040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNB2"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="510" mass="57843" checksum="B42D5445CDEE9660" modified="2020-04-22" version="1">MNRHHAFTNGYAAYPRGHGSTFSISPHRFQPRPQPALRRRKQLIQRLFLIGGVSLLLLVLIFPSWRAALLPVVSLGLLSSGEDTQIQTVRYYDLSAVQGTGNGWEKGERVLMCTPLRDASSHLPMFFSHLRNMTYPHHLIDLAFLVSDSKDDTLGMLNRMLEELQTDSDPKMPYGEISVIQKDFGQKVTQDVESRHGFAAQAGRRKLMAQARNWLLSATLRPTHSWVYWRDADVETAPFTIIEDLMRHDKDVIVPNVWRPLPDWLGGEQPYDLNSWQESETALALAETLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMELDGVGGVSILAKAKVFRSGVHFPAFSFEKHAETEAFGKMAKRMGFSVVGLPHYTIWHLYEPSVDDLRHMEEMEEERKAREKEESEQAERSARVNNLFRDIKPESEADNAIIRDNMQTEKDELTASENPKKPEAGKAEEATAQKPPKVPGQEDQKASDSWKSKDLKDAEEVPAIKPAKEQAGVAHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNR4</accession>
    <name>A0A5N6TNR4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_159200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742181">
        <property type="protein sequence ID" value="KAE8147988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNR4"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="28228" checksum="B7DDF4C41A91914F" modified="2020-04-22" version="1">MASSSKPPSFLLYTCIAHRTTILAEHSAPGTSSTAASSLASIILPKITHEKSQKLTYTHERLFVHYIADSPTGATDEQTRHEPNSYAPLSFIVVATAEQGRRIPFAFLLEMKRKFLSTYPPSSTDFASLPAYGCAAFNTELRTLLHTYNTAPPSDSLASARREIDSVRDIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRVRSRGLRRRMWWKNVKLMILLGVVIVFLLYLFIGIGCGLPAWGNCVSHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNX5</accession>
    <name>A0A5N6TNX5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_26841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNX5"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="52069" checksum="6745089CDF213BD8" modified="2020-04-22" version="1">MYHVRQGHSQRVLHDLHKKYGPVVRIAPNVVDLDFPGLIKTIYNTKSDYRKTEFYHGSSAKSNGKIIYNLFSECDPEVHARQKRPIAKFYSMTGVLPLESHIDEVISYFCQRLEEGFVDGSNAGKTCKLEQWLSYYTWDVVGKATFSELIGYLQHGHDFDGTIATSDKAMDYFSLIGQLPVLDHLLDKNPVYRIGPPSFGNITNISIQHLVSRRQGKETSAHDPSKPDFLDRFIDAAAKHPDVVDDAQIISYLMINMIAGADTTAIALTAALYFSLRSRSVWTRLQQEIPALQGSVVPYHTATSYPYLTAVIREAMRMHPGVSMTLERYVPVEGLTLPTGQYIPQGCIVGMNPYVVARNRSIWGEDAEVFRPERWLRDPRESEDEYQARLRLMNASDLAFGAGSRVCIGKNLGMLEVYKVMATLVSRFEIELVDACEWKTHNSFFVRQEGVNVRISRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP02</accession>
    <name>A0A5N6TP02_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_142135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP02"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="39"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="426" mass="46989" checksum="ABE3F00BA7B7C7D0" modified="2020-04-22" version="1">MAPGLDILNQKLHAVLENRRKEGRLIMPPSAATLAEMRDFGSNDGLSLSSSGVLSATFLRELEKHPSFTIGSGSSRILDGTQHYLESLERDLAQFHGAESALFFNSGFDANVAIWSTIPQPGDVIVYDELIHASIHDGMKRGRAATALFLHNDCASLRSCLRDVLDQDPAIAKGEHIVFVALESFYSMDGDMSPVLEIVQVVQEELPLGNYVLVIDEAHSNGLVGPNGSGYICHYGLEQEFGIRLQTCGKALGSTGAVVLANGTIKLSLLNYARSVMFSTAPSFLTVSGVRAGYELLASEEGEKRRHRLQQNLRYFYQCLTESPWWGSVKQQRILSLPTEPTWEMEPFLAPVIALVTQPGMETKLAEYLRQAKYWVNTANFPLVPKTKSRIRIVIHADNTIDDIGAVVRLIGEWAQRQMIVASSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP05</accession>
    <name>A0A5N6TP05_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phophatidylserine decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_168686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP05"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="446" mass="49853" checksum="0E675275F7CC81EE" modified="2020-04-22" version="1">MPHKHGYHTPRLHKLGEWMPSTLDSHHEWVGGLIAHVDSKADHELHPVLKEFQHLIETNTRVYLLIEAMFREVPRNRVYATDPTGCPQMRDYRHMLKVLNQLLTSAPSWSDFTHRVGLVGLPINAVLDWPMGTPSGYAAFLDPEINAMVKKVLNAWGEYLQSPESAHVLDDSQYGWFGETGKESLIAVANVGETSYAFEDMFVCDPTKKYHGYKSWDDFFTRVFKPGIRPVASPDDDNVIANACESQPYKVARDVKARDCFWIKSQPYSVYDMLAHDPFADRFVGGTVYQAYLSALSYHRWHAPVSGKIVKAYVVDGTYYSEPLFEGLGDPHPSENQDIDAVGEVTAQEYLTATATRALIFIESDNPAIGLMAFLGVGMCEVSTCDITVSEGQHVKKGDEIGMFHFGGSTHCLLFRKGVNLDGFPSADTDRNMPVRAQVAVVSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP08</accession>
    <name>A0A5N6TP08_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mono-functional DNA-alkylating methyl methanesulfonate N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_131736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP08"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141035" checksum="DDCF4C4E703F213D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP82</accession>
    <name>A0A5N6TP82_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_22326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742172">
        <property type="protein sequence ID" value="KAE8148166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP82"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="108" mass="11042" checksum="076861222F879D25" modified="2020-04-22" version="1">MSTAELACSYAALILADDGVEVTADKLQTLLTAAKVQEVEPIWTSIFAKALEGKDIKELLTNVGSAGPAAPAGAAGAAAAAPAEAAAEEKKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPJ2</accession>
    <name>A0A5N6TPJ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742169">
        <property type="protein sequence ID" value="KAE8148225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPJ2"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361:SF1">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49056" checksum="32AD4CD91318979B" modified="2020-04-22" version="1">MSTQSPTPPTPRGIRNNRRNPKRNMTPTTQKAVLLATPPSSPPRHMSPGGTATDSSVNLSKKKYGKSNKKPRDAPKASPAQRNGHRHTSSHANNATPQLKDSPHYAGPTFHASPAPSALPIPSFISKSMPDPELTTAQDVDGDLCEIGSECEVTPSKPRSRPHFQDGEPESTPLDFLFKAAVQARSSQAHRSPEAGFRACSPQMDSSKAQPKPKGSSGLFASEMESPEPRTAQIGPSFATSYKDRMDALRSTNSPSPPLAELDEEQRRAKTEALKNLLLNPRPQRPTSAAKPCHNHFDTLNEWPAAGSEVSHVTTPPRITSGPPSAPSYQSLQECNHYPAGNGWQMHIPNAYPVGPQPYGQYSIPRKERIPFIPVNSTNPGEVIPPPVGHEQLGFASHHAQVHYQSPVLQSMPTSTPTNVLDTKRIEDDLRRILKLDVSQGLTSNGIQSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPT4</accession>
    <name>A0A5N6TPT4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_131309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPT4"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30420" checksum="00285ADE6BE50B8F" modified="2020-04-22" version="1">MGKLNERDGIAILQLIIFPFILAAAIFIWNRTGWRVGSKIWRYAVTLSLLRIAGSIATMISIDHKSNGVTRAENVCELIGIAPLLLTYIGILRQIDTEEKIPARPLTFVTILGFIGLILGIAGVSNADVTYTKVDGQWTYTYHPGKLVQASMAIFIAVFIITILLTSWLFFQLLFTLKRFQRKLFLATALSTPFLIVRLVYSALGDYDGDDTRFSLIKGNATIYLCMSVLEEIAAMAITMALGMSAVLERDFIKPQFEHRQETRDGLKYNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR45</accession>
    <name>A0A5N6TR45_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_157638</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742147">
        <property type="protein sequence ID" value="KAE8148770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR45"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="716" mass="78077" checksum="F03CD28F88874E21" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS78</accession>
    <name>A0A5N6TS78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742132">
        <property type="protein sequence ID" value="KAE8149164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS78"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="467" mass="51524" checksum="1436A97E0C61AEC3" modified="2020-04-22" version="1">MALSTRSVRHASKLAQSSRPLAQYTARRSYATAEPDLKSTLKSVIPAKRELFQQVKQQGDDVIGEVKVSNVIGGMRGLKSMLWEGSVLDPDEGIRFHGKTIKDCQKELPKGPSGTEMLPEAMFWLLLTGQVPSTSQVRAFSRELAEKSHLPQHILDLIKSFPRNMHPMTQLSIAVAALNTESQFAKAYEKGLNKADYWEPTFDDSISLLAKIPRVAALVFRPDEIDTVGTQALNATQDWSHNFAELLGKGGEKHQDFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDEDVRTYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRSDVLANPVFQLVKKNSEIAPGVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSK2</accession>
    <name>A0A5N6TSK2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_130636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742134">
        <property type="protein sequence ID" value="KAE8149119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSK2"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="516" mass="56939" checksum="21A25900723B07AA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSK8</accession>
    <name>A0A5N6TSK8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_3790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSK8"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930150" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="345" mass="37369" checksum="C5BF281049CC8F12" modified="2020-04-22" version="1">MHPVLSLLAGAGVVSAWTEIHHKTFMNKNVDPIVLPGTYTSHMHTFFGSDAVTKDMPTSADLQKGCYSGENPNDLSAYWVPTLYHVDGDVFTEVPVFRFSTYYINSFSEIAIPQDFSMLSGNASAQSQAAAGDSPNNLEWFCEGSDERESDIAKFPTSTCDQHLQVSLRFPNCVNPDNLAEYDFSDDSNKCPEGMKQFSQLRYAVRYDTKSVAPDGWSGDAPFQLSCGDAVGNGYCFHGDFINGWFEDAAENMLNNGGGGYDDGQFIGGEHGEAAAEATCTPADQDPDNGTSDYWTSVEMKGGDVPADASETSAAVATPASTTFMSASIPKPTFSHKRKFATRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTN1</accession>
    <name>A0A5N6TTN1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_155767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTN1"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
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                <person name="He G."/>
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                <person name="Devries R.P."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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    </evidence>
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</entry>
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            <strain evidence="3 4">IBT 18842</strain>
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</entry>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="325" mass="35866" checksum="ECB206C6767AB348" modified="2020-04-22" version="1">MVKTLSLGDHQVPVPGFGAIGLNSAMGTDLDLQQSEPVLLKAIELGCTFWDTAITGENERLLGDFIKKHDVREKLFVASKCGFDVFGPERKVTNSASHIKEYIEGTIDRLGFTPDLYYLHRIDPNTPLEESIGALDELRRSGKTKYIGRSECSAATLRKANAIAKIDAVQAEYSAFETLHETSGLIETAKELGVAFVAFSPLGHGWLVDDFQFQSPDDFAPNDFRRTVPKFQGENFYKNKAIVDEIKKLATRKGCSVAQIALAWVAAQGLITIPGTTKPSRLEENWASREVELTEDELAEMRKIVDAAKPVGARFAPIYESMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVY6</accession>
    <name>A0A5N6TVY6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_110602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVY6"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000048">
        <property type="entry name" value="Sreptomyces cyclase/dehydrase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="90"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="245" mass="27551" checksum="191EBFC4DFF951C0" modified="2020-04-22" version="1">MKSITLSRQLSRTIHRPQSRRLSILPQQTPTYTNTLNPTRKTLNPTIKQTQSKRPFNLSSLSSLLTNNNNNNNNNKNPEGRTLKASRTLPYAPNPLYKVISSVESYSQFLPFLTASTVTARDPETGYPVRAFLTVGYGPLSETFTSRVDCDRSRWIVEARSGAKFGVDSKDGQDVFPGAVEGIFEYLSTKWVLTPLGEDVTRVDLEIRFEFRSQLHAAMMGAVEGQMAGVMIEAFEKRIREVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW49</accession>
    <name>A0A5N6TW49_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein Gephyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_172035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW49"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000013">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="443"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="707" mass="74210" checksum="490B732E2C1BAEDD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW72</accession>
    <name>A0A5N6TW72_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_129398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW72"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="43"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="440" mass="50896" checksum="0F95DFC2B2CE03D5" modified="2020-04-22" version="1">MATRMKPSKVKYQFVEEVERLDFYVPGGYHPVMLGDEFCSGRYRIAHKLGFGRSATTWLAEDMENHRLVALKISTAESADRTHEVEILSRLAKAKSNLPGQAIVQNLLDCFTIAGPNGIHRCLVTDAARLNMNEVKEYPYHRLLPLPAARAIATQLVLGVQFIHSQGIVHGDLHPGNILLQLPPSMQNMTFEQLRAEIREPVKEPVVRKDGAPLDPGVPSELIIPIWLGIDSDKVALEDSPIMIADFGEAFDPQDKNHYIVHTPLLLAPPESRFVQAGDLDEPLSFPGDIWTLACAIWEVFGCRPPFESFPISLDEVTMEHVEMLGKLPDRWWKEWKERNNWFDEDGRKNVKENLQQWYGNTHRDWNTRFDEYIRQPREKHKFELFSKEEEMAFRGMMDLMLVLEPSKRATIDEVVECEWMQRWGLPEWRRMQDLIRMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWD6</accession>
    <name>A0A5N6TWD6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_129331</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="361"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="19">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="18">
        <location>
            <begin position="756"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="20">
        <location>
            <begin position="1010"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="623"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1214"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="685"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1221"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8150708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1785" mass="199484" checksum="8DF5D55C9F191D1F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWE3</accession>
    <name>A0A5N6TWE3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_153864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
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        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="369" mass="40560" checksum="0473DBE9B86D6918" modified="2020-04-22" version="1">MRIATLQLAPKLGDVEGNIRRANELLRSGKVLGGAGIGLDILRPNILVLPELALTGYNFPSLEAIKPYLEPVGTGPSAQWAKDTARRYQCKVCVGYPEVEKSDAEGSDSQAETYYNSLLVVDENGEVLVNYRKTFLYYTDETWAAEGDAKRSFHELTFSKSHEQQALSAKVATSFGICMDINPYKFETPWTAYEFANRVLDSKSELVILSMAWLTSLAREELDALDGEPDLDTFNYWIQRFMPLIRKKLRHDANFDGEDPQAGKKIIIVFANRSGEEEGVEGTDPAKYAGTSAVIAVTQRPSLSGETSARDGNSGEESDGNESGENDTSSFDVKILCRDMVGATEQGICFADTTADPKMVFGLVKASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWH4</accession>
    <name>A0A5N6TWH4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_171961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151379.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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    </evidence>
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</entry>
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                <person name="Nybo J.L."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Baker S.E."/>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
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    </feature>
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        </location>
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            <begin position="1682"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
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    </reference>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U010"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="483" mass="51253" checksum="0071A596E46B8175" modified="2020-04-22" version="1">MSAPVTNGSKAAIPLIINNESAVTKTVFNVYSPATGKVIDRCASASVDDANRAVQAAKDAFPAWSKMKPYDRRDILMRAADIMLSRREELIGYQMEETGAARPFVEKTFELGAGFIKDFAARIPSIEGSVPSVSEDGECAMVFKQPYGVILGIAPWNAPYILGTRSIALPLAAGNTAILKGSELAPKCFWAIGDIFREAGLPAGCLNVVYHQPSDAAAVTTALIAHPAVRKISFTGSTNVGAIIASTAGKYVKPVVLELGGKAAAIVLDDANLERAAMCCTIGAFLHSGQVCMSTERIIVQRSIADKFRDILAATSEKVFGKHTPASVLVTSAAVKKNRDLVSDAVSKGADIVFGNTNASEACSNALRPVIVGNVTKDMDLYSTESFGPTVSLMVVESEEEAVELANDTDYGLTSAVFTDNLFRGLRVAQQVESGAVHINSLTIHDEPVLPHGGWKSSGFGRFGGGPAAYDEWLQTKTVTWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U046</accession>
    <name>A0A5N6U046_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_83833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U046"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63405" checksum="8001110E2A4E81A6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0A6</accession>
    <name>A0A5N6U0A6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_138307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0A6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="79"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="404" mass="46201" checksum="6583AC03961FAAD3" modified="2020-04-22" version="1">MTEQKTFVLRPTKRKSDCLDEESTNEACVNSTASPQKRVKLVINPPKLRLKLTLHPLPSTYKGEKIPKLEENFESDGVLGQSGFIGQGGFGSVKIVYKRSNKETRRTKNKAYAAKVVKRIQGESLVQYTERVFEEYSISKRVKHPNTVMAEKLTRDQESLSCVMEYCKHGDLWDLIRKGYLSWEDKKCLFKQLLLGVGHMHRCGIAHHDIKPENAVLGDDSVLKICDFGLAHVVETKVQVRTDGKRKQNRTINWCEPSTRGTISYLPPEAIEPKDKYDPWPVDVWSCAITGIHIFCGENPWNTANSEEDGAYADFLEAWTNFLEEFPYSGITKTRYPVCRDLFAFLPVGLQHLLIRMLHPFPEMRITMRDVLKDAWVQDIECCSPGMPLSVPRPVHDHRPPNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0G2</accession>
    <name>A0A5N6U0G2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0G2"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025033324" evidence="3">
        <location>
            <begin position="18"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="647" mass="72674" checksum="B2A1F0A461B01B80" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0S7</accession>
    <name>A0A5N6U0S7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0S7"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="351" mass="38517" checksum="8AF9435174E65C6C" modified="2020-04-22" version="1">MPPRIRLSSGRIAQSVRRQRLVCQHELPVLTRFASTATTPAATPEQMTQSVAPIARYPPSQPPSHRNPEYRRSQLLRQYTSVIRTTPLMVFFQHDNLQSVEWAAIRRELAKALQKVDDQIASEGRSLPPLAPHVKVSIVQTSIFEVALRIVEYFRPNASTLKTGQTPSAVDPATQTSAEISLAGSRDDPTLSHDLSRVAHDAVKPMKGKHEMSPILVGPIAVLSIPQMSPEHLKAALTVLCPKAAGFPTPTRRANPSWHELPVQNGLNKLALLAARVDGKVFDVEQTKWVGSIEGGLDGLRSQLVMALQSMASSVTNTLEGAGKSLYFTLESRRSVLEDEQKGPEEKKNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0V0</accession>
    <name>A0A5N6U0V0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_151492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0V0"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="117"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="480" mass="53138" checksum="0D2E894D1F0C2137" modified="2020-04-22" version="1">MATPVTLETLPNLLADDIKVKVAGIDCDGILRGKVMSKEKFLGIAQKGFGFSSAVFGWDMQDVLYTTDANIAPKDSGYVDFIAVPDLSTFRRIPWEDNIPFFLVRFVQNGQDVSADGRNMLNSICDKLAADNCQAMAGVELEFMNFQTPSEDGYSANASQTQNVATFLEKNVPSSLRPITAGSFSYSATRPVAFKKYFYDIFNTCSQINCDIEGWHTEGGPGVYEAALKVCNVREMADKVALFKLLAKSIGVEHGVTPCFMAKPIQGQPGSSGHIHVSLCDLDGKNLFARETPDTNAAWPDAAGLSDFGRQFLAGVLEALPDIMPLFAPTINSYKRLVENFWAPVNVSWGLEDRMASIRIITPPVCKPGATRFEVRIPGADLHPHYALSVILAAGWRGVQKKLEIKVPPMSALKETNERPEMLPNTLEEALKRFNAPNSIAREILAGEFVDFFTATREHELRVWREAVTDWEFKRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1Y6</accession>
    <name>A0A5N6U1Y6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1Y6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="53" mass="5941" checksum="304D303213CCBE96" modified="2020-04-22" version="1">MLNLYRLYSAITFSGHSSLFSCGLPVVICDIIRAVNPVKVGDLFWRTGYLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2F5</accession>
    <name>A0A5N6U2F5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_127812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2F5"/>
    <dbReference type="OrthoDB" id="5345625at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="38172" checksum="9C2A43FAEB0009C8" modified="2020-04-22" version="1">MQSTTLLSSPVKDGRRVLGEKPANACLSPARRHAASPTKRSLLGPLSSPQKLLPSPSFVGQKRTIDQVNDQDSLHGESRAETPSLHDVREETPTQLTADNDDRPDQEQTDARDESLFDKQQTPQPQESQIPTTQLPAAGLTRNVPEDPETRKQFIQEKAALLRDRIQSAMRHVRDPQFDRRLSELEAHSRKFPRLSLPEATAPSPQDAVTPRQQQDSPSSAATTPRALQPPIELKPSSESTSTPHGLSSPPLSTGNSGLQDPMRTPTQRSRRRADSTDSPVQLSSPPATVSRTGRDRLVGTSDETEEDCEGTPTEKQAVTPSQRGDAVDGLLKLMNTGDKRESSNTWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2G3</accession>
    <name>A0A5N6U2G3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_150518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2G3"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36695" checksum="C81973BC9E992878" modified="2020-04-22" version="1">MPIPNPQIVMSRSISNELDEIDFSALDLVCPINSDDIKNRWIQAYIPIPGQTVKEYPHGVSSFIYSTLKSYSAVAVKGRGTLPFIHPKQLMAQPAGSPLTTCLSLVRICSNQLPGSKHAAVFVLQREMHALYDLRDRYNGEALFAGFQAYLIYAMVLFFWLGQSCDDHFRAIMTNLQELACASARHGLLCAADQRRARPRWEEWIVTEAKRRTLFVMYLFDSVLSTQEGLPTFLGTELHGLPAPANKLLWQAGSRYEWEREYNIHMAEWMEGGLTIDELWPTPADLGESGIMRRRARVDQWLENLDEYGTMLYAIMRCTHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2M7</accession>
    <name>A0A5N6U2M7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_150562</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2M7"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="422" mass="47176" checksum="A91E0D9B56EB07DE" modified="2020-04-22" version="1">MGDVAVENPANTVTPHTKPAPFDTIPNIDTIEGTGTDGGDEYATLKRLQRHLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGENEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVNGSEFVQKYLGEGPRMVRDVFRMARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFEQSSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTVASKMSLSPEVDLDSLIVRNEPLSGAVIAAIMQEAGLRAVRKNRYNIIQTDLEDAYAAQVKTGQESDRLEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Y0</accession>
    <name>A0A5N6U2Y0_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_59637</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="127" mass="14890" checksum="29F8D6F7DDF20D72" modified="2020-04-22" version="1">MRLSEYVHQKEQLLEDIRFLFLSSSVIYLFILFYFSLFISLRISSDCCTFVILSDMIVLGEHNIGLYPFIISCRGRAYYLWSQERKKKGKNIHTEGDKEREKKKPYGLPQSTGYSPFFLRSEGVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U303</accession>
    <name>A0A5N6U303_ASPAV</name>
    <protein>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="149" mass="16972" checksum="B6E34ED3003DE23E" modified="2020-04-22" version="1">MITFIFVALNVFLLSLYGRYFLLPVGVGVLYLSSFPLLFSLFSLFIFHFFLYLIFLTFPIFPFPFSLYPVFFSFDFEEGESDGLHLVFSVCADFENLPILSLPSDHLPHKPVPHHFPSLLVSPIISPSGISKQNTKSKEGGERGERIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U323</accession>
    <name>A0A5N6U323_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_47937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U323"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="702" mass="79178" checksum="6BF74D19E792217F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U329</accession>
    <name>A0A5N6U329_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U329"/>
    <dbReference type="OrthoDB" id="4510634at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="59" mass="6403" checksum="A0ED6D9038023D2B" modified="2020-04-22" version="1">MCGVPCSPFLSSFLCLRNWGGEGEWVSFDSDYSGWGGASSSFLGEFVLLNWEGFALADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U332</accession>
    <name>A0A5N6U332_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_150543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U332"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.180:FF:000006">
        <property type="entry name" value="Probable 5-hydroxyisourate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="139" mass="15169" checksum="347FB69DD54513E2" modified="2020-04-22" version="1">MSRDPITCHVLNTLSGTPAANLPVTLTLLSAPSNSQSPVSFHAITNSDGRVANWTPVTSSSPSVPAILSSLPAADSKTNWSVRFEVGPWYEAQGVESFWPEVEVKFTVKGRGREGEEGWRHYHVPVLLGPWNYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3M1</accession>
    <name>A0A5N6U3M1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_42700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3M1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12136" checksum="069B7C6BE12D4D6F" modified="2020-04-22" version="1">MAPLVPIFSAEALPGHVSIVRKNFQERRRKGGPVDLEKCKLLEMLQYSCNPPQEGIPKPGVVVCKPVVRLFRRCANGLTVETTAWEPLRLAKEEEANRKAAEADLKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U403</accession>
    <name>A0A5N6U403_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trimeric LpxA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_127427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U403"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="201" mass="22607" checksum="CA99DE949842A34B" modified="2020-04-22" version="1">MLTNIDEKENLARMERGELYYAFTPQLVAARQRCSRLVSRFNRAGELSRREIAEFWKELTKSETPLPSPGQTDEEEDALLQDYPWIERPINIDYGTNLAVGTNVFINFNCTFIDTCLVSIGWRTLVGPNVSFFSGTHPLDPDLRNGTNGPESGKPITIGEDCWIAGNVTVLPGDVPEYHVVAGNPARIIRKLERKVKPDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U411</accession>
    <name>A0A5N6U411_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_127369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U411"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="30769" checksum="70CCE2BEA6CB4D8C" modified="2020-04-22" version="1">MQIPLTQHALVVEEGGRVSLQTTHRLPSLKPNMVLVKTHSVALNPHDVKTLDYYSESGYIPGRDFSGTVHAVGSSVSKSLEVGDRVCGAVSATGGFGAFAEFVAVCGDLLIKIPDFMSIDEAASLGVGTMTAGLALYHTWELPWPKLPASEGGMHVLVYGELLRLSGCIPITTCSPRNFPLVHARGAAKAFDYNSPTCVLDIRSYCGDTLGYILDCIADTGSSQICYEAMATKGGRYIALNILPKNISSRASIKTEVTNVQTTYGEPVDWKGWTIDARPQDYQFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U422</accession>
    <name>A0A5N6U422_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_137068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U422"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
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</entry>
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                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
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            <end position="191"/>
        </location>
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            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
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        </source>
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        </source>
    </evidence>
    <sequence length="359" mass="40731" checksum="3E572B1D61CC4F4B" modified="2020-04-22" version="1">MLHFRSKPTTDTDSFRGSFFIPESREDWLSLARSSGLIKKALGSLAKFGSGSRVKKKQHVLFKAIWTPPAKFYQLVDHAERYNLKDVWQDACNLVASSGELQRYLSLVGEPQKFALLTETDGAWPGSWVPVLQWQNRVLEFCKMKSAQATGSIATRSQAGKRKRETAPQVEQVLEDYKAPSDESVTNTALVLLLDAVLRLVPSAGCEFTMFRVAFEANFRQGGFKALTDGALWVKGNEDDIRAILEVKKGHRYDNHDKIRMQETAELVCWLKKSYQPWLEFFHGHKILISEDGDQVWITFAKPSSTYAQYLSQDTPVEDAFLDMTTYGPYRLDDKRQMKGLCILIAAIVLRVVSSLRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U672</accession>
    <name>A0A5N6U672_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U672"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1161" mass="129930" checksum="7F51C4CC1F724BEE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6P5</accession>
    <name>A0A5N6U6P5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6P5"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="184"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="403" mass="44856" checksum="E305A4D0E1953869" modified="2020-04-22" version="1">MGSIASAKVSIEEKLDQVIAAATKYKERLSEADSFDARYDLMAKATNLVHTIRGPADMVFANFENASNMGAIRALLEAGVFHAIPTGGTSISAKEIAAETGVDKNVIVRLMRAVTPLGPFRETGEEQYAHTPFSEIYLAPQMAAVFGLMIDEYVPAILGNYEFLKQQNWKNNISLRNNPYTHINDCEGQTMFENVSQSPDRITRFNEAMMAQDSSLPAVELYPFAEELSGLASDNTPTIVDVGGGRGHIIREIKRVAPGLKGRFILQDQATVIEDNGKEIETHGIEAMAHDFFEPQPVKGALVYYIRRCLHDWPDEPESQQILSNLAGAMDRERSRVLITEYILPDVGATMFHAWMDSTMMTFAGRERTEKDWERLCDISGLKLVKIWRVPGIPVGVVEARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6V4</accession>
    <name>A0A5N6U6V4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_147609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6V4"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="159" mass="17930" checksum="6E890BE9178FEBD5" modified="2020-04-22" version="1">MARREPQFNQQVLVDTTPMPADIPSVQEIGATSAPLTSAAYFIGDRCKAFNDDFMKCKSESNGKGEIDCLKEGRKVTRCAASVIKDINTHCLKQFTAHWECLENNNHRLWECRKPEMDLNKCVFDKLGLKKTIPGAPENQTPVHLRPTQIYASFPGPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8A8</accession>
    <name>A0A5N6U8A8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8A8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="438" mass="50341" checksum="EC27CEC158F5DB51" modified="2020-04-22" version="1">MPIRPSIPRLSTLLRKKPFSMPSPGPPLSPYILVDEETSPVYDSKHFYPAKPGEVLANRYQALIKVGWGVSSTVWLAPYRHVEEPERVLALKIVNSNASAAGHEREVEEHISTANESHHGRSLIRTLLDSFEIKGPGGSYSCLVYPPMREPLSMYQRRFVDRKMPLPLLKTYIRALLTGLEYLHHECRVVHTDLKLENIMVTFEDPTVLADFIDTQLEKPMAFKIDSTGRPVYQSCNDFGPLKGLRSVPQLVDFGLATRLEEDDDWGVWPIQPDHYRAPEVVLGIGWQMSTDIWNFGVLLWDLLEGKELFQHIYDQNGRYDAKLHIAELIVLLGPPPLEIIQRYQCMREYAWPEPVRREDDRVCETAEEYFCGPFFGTDGHFLYEDLIPERGLDDTVPFLQGEEREAFLDLVRGMLVWHPYARKTAGELARHPFLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8E3</accession>
    <name>A0A5N6U8E3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_135516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8E3"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000009">
        <property type="entry name" value="Hydrophobic dipeptide epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF3">
        <property type="entry name" value="ENOLASE SUPERFAMILY MEMBER DDB_G0284701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00180">
        <property type="entry name" value="muconate_cycloisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="147"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="371" mass="39869" checksum="EB4591BF1EA356AF" modified="2020-04-22" version="1">MTDLSIARIDIYKVDLPYSGGVYHLSGGREYRSFDSTIVRITTQTGLTGWGESTPFGSTYVAAHALGVRAGIEEIAPKLIGLDPRRVDRINDAMDAALLGHEHAKAAIDIACWDVYGKSVGLPVCELLGGRTESKLPIISSVPVADPEEMRRMVDSFRGKGYRGHSIKIGGEPVADAARIAASLADKREGEFFLVDANGGLSVEVALRMLRLLPPGLDFVLEAPCRTWRECASLRRRTDVPMVMDELATDESSLIHLIANDAAEGIGLKITKTGGLTRSRRVRDICLAAGSTISVQDTTGSDIAFAAIVHLGQTIPERFLRCVLETRDMVTVTTADGDFGVVDGFVTAPRTPGLGVVPRMEVLGEPVASYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8F2</accession>
    <name>A0A5N6U8F2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8G2</accession>
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    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="125"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="153"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="184"/>
        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="568" mass="61860" checksum="263BE2FE180DEF8B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U8N9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_64097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8N9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="88" mass="9842" checksum="079998E907FA30E9" modified="2020-04-22" version="1">MQIRGVCCKSARVGVSFNYFIIFISFYFSPFIFPVEGLGYIQAVTSIILYACPPRGCQTLERCDEYSDVIRSGGSRLGLEGDSSRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8S7</accession>
    <name>A0A5N6U8S7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_82632</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8S7"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="149"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8154819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="46875" checksum="5489B64FA99F58AB" modified="2020-04-22" version="1">MSLSPEQIQIIKATVPVLQQHGNTITTVFYKNMLTAHPELNSIFNTANQVNGHQPRALAGALFAYASNIDNLGALGPAVELMCHKHASLYIQPDQYKIVGKFLLEAMGEVLGDALTPDILDAWATAYWQLANLMIGREADLYKQSEGWTDFRDFRIAKKVPESSEITSFYLEPVDGKPLPQFRPGQYISVQVFVPELKYPQARQYSLSDKPRSDYYRISVKREAGLNTEDPNAISKPGYVSNILHANINEGDVIKVSHPYGDFYLSEAESPNPIVLIAAGVGLTPLTSILNTILSSNAADRKIHFIHGARSTAVRAFKNDVIALKAKYPNLHATYFTSHPTAEEKEGVDYDYAGRVDLSKLDASKDLFLDNKQTEYYICGPERFMTSMRKALHGASVNEDRIKLELFGTGGVPASLYFWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U912</accession>
    <name>A0A5N6U912_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U912"/>
    <dbReference type="OrthoDB" id="4457430at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="96" mass="10618" checksum="4DF8C1A11B076EF4" modified="2020-04-22" version="1">MPNPQTVNVAGIPKRILLEALLAVTKDITATELNMDDAWREYMIYKGPASQICGRVLECDIHPDAVNPVGFDRANRQEGMFAAVVNGLHKRLNDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9D1</accession>
    <name>A0A5N6U9D1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="442"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="552" mass="61133" checksum="D9FFA2C7CDA1AE60" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
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                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAE8144253.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    <sequence length="260" mass="28323" checksum="D4F6E449506426C6" modified="2020-04-22" version="1">MSRNAQVEEVYDSDPDEVAPSDSTPAFNDSLLSAAGISPQGASSMPMRPAPEPRREIPKHYQCLYPVYFDKSRSRAEGRKVGAELAVENPLARDIVDAAQMLGLNVGFEPEKLHPKDWANPGRVRVHLKNEDGKLVNPKIKNKHHLYILIAQYLKAHPTNEKSPYRLRISGLPMPEKLPAAPPAPRGWKIGTILPIHSPAYTGGGVSDNPLKDAMAEMQNMQGMPGMPQIPGMPNLAGMMGEPAGGSGEKKKKDKKKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD44</accession>
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        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_145810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Simmons B.A."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
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        <property type="protein sequence ID" value="KAE8144263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP105-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="408" mass="44948" checksum="F5232758DE9F6E36" modified="2020-04-22" version="1">MSPVEPSYPKFPFARPSGDEPPSEFHRLLRECPVSRVELWDGSHPWLVVKHKDVCDVLTDPRLSKVRQREGFPEMSAGGKAAAKNRPTFVDMDAPDHMRQRSMVDAFFTDDYVTARLPFIQDTVKHYLDELIEAGWDKEIDLVKHFALPIPSHIIYDILGIPHGDFDYLSGCDATRTNGSSTAAAAQAANEELLKYLGGLVGSKTTSPGKDIISSLVVEQLQPGKLEKHDVVQIAFLLLVAGNATVVSMIALGVVTLLEHPDQLSRLIEDPTLSKPFVEELCRYHTASSFATRRVATVDIGIRGQTIKAGEGIIASNQAANRDPEVFPDPDIFNMFRKRGPEEALGFGFGAHRCVAETLARAELETVFSTLFQTVPGLRLAVPKSEIQWAPLTKDVGIVGLPVTWDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD82</accession>
    <name>A0A5N6TD82_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_167070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 13"/>
    <dbReference type="EMBL" id="ML742562">
        <property type="protein sequence ID" value="KAE8144345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD82"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8144345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="208" mass="23083" checksum="6A4BD29D8A14B561" modified="2020-04-22" version="1" fragment="single">NITFHASALTRNERSSARGQKGLTIWLTGLSASGKSTIAVALEHQLLQERGVHAYRLDGDNIRFGLNKDLGFSEKDRNENIRRIAEVAKLFADSTSIAITSFISPYRVDRDTARQLHEVPTPGEESGLPFVEVYVDVPVEVAEKRDPKGLYKKAREGVIKEFTGISAPYEAPVKPEVHIRNGDDLPVAEAVKQIIEYLDSKGYLPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDS0</accession>
    <name>A0A5N6TDS0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_166759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="ML742509">
        <property type="protein sequence ID" value="KAE8144472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDS0"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000220">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000044">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="3">
        <location>
            <begin position="371"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="642" mass="70777" checksum="0D309F3E1BE8E59E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE01</accession>
    <name>A0A5N6TE01_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_93058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="ML742510">
        <property type="protein sequence ID" value="KAE8144470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE01"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="144"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="365"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="869"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="940"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="869"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121016" checksum="8CA9620058508705" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE27</accession>
    <name>A0A5N6TE27_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BET3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742488">
        <property type="protein sequence ID" value="KAE8144547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE27"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000020">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="189" mass="21357" checksum="C4C7B8AFF146DC71" modified="2020-04-22" version="1">MSFDAPALYSNAFDHQARTLSASCLDFLMIELVPMAERLAKELSTDDKTLDEDELKETVFFRLESLGYRVGQGLAERFSRDRPRFTDNLDVIKFLCKDLWTTLFKKQVDNLKTNHRGVYVLTDNSFRPFARMSMSVRSEAVAVAQAYLWFPCGVIRGALSSLGINTTVQAETAELPGATFQIKTVQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFB7</accession>
    <name>A0A5N6TFB7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein Kri1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_165573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742402">
        <property type="protein sequence ID" value="KAE8144997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="472"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="609" mass="69965" checksum="63B339C17B1115E5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFB9</accession>
    <name>A0A5N6TFB9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_165995</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742430">
        <property type="protein sequence ID" value="KAE8144819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFB9"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol transfer protein sfh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
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        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="177"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="369"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8144819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="50090" checksum="76BF8CBBA9EABA01" modified="2020-04-22" version="1">MADQQEKAPAAAVPESQPPTQPAETTTQGTAAPAPEAQPEQPKPAEPTPNDTTTTTEEPSKPEAPKEAEAEAPAPAPAPAPEAESAPAQEQQGEEKPVDNKPEYLAKNPALAELFDHLPAILSKTGHHEMWGVALKDSEDIPTVNVLIKFLRANEGNVKLAEEQLTKALEWRKQTNPAALVEGRYSSNKFGGLGYQSTYKEADGKETVITWNIYGSVKDLSNTFGDLDEFIKWRVALMELAVKDLKLDQATSVIDYEGEDPYQMIQVHDYMNVSFLRLNPSVKAATKKTVDVFSTAYPELLREKFFVNVPSLMGWMYAAIKVFLSKNTTRKFHPVSNGANLAREFPAAVKDQLPKVYGGNGPALQEGARAVSLEEDSEPTPAPTEELTEPAKTEQEPPKEETAPEPSKEESPKEKVEETSKEEPKEEPEPEPKQTVADEPAKAEAAVTTQETPAAAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFE2</accession>
    <name>A0A5N6TFE2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_134152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742399">
        <property type="protein sequence ID" value="KAE8145026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFE2"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="146" mass="16911" checksum="9E1066BB0CA567D1" modified="2020-04-22" version="1">MEDAFSRFPGFQPNPSLSATEEFSRLAHHMNWATGSKTYRKERVKFASTEFERYYHIGNKLQNYRALCQELRVEGPLTSVTQCRKALAKVHVNIFDLIDSRRTGAAVQRFPNQAALRKYTKDTEKIFPKQAAKADGFLKELLRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFZ6</accession>
    <name>A0A5N6TFZ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_73773</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers mannobiose over mannotriose and has no activity against polymeric mannan. Is also severely restricted by galactosyl substitutions at the +1 subsite.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="ML742362">
        <property type="protein sequence ID" value="KAE8145304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFZ6"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="14">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="12">
        <location>
            <begin position="196"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="13">
        <location>
            <begin position="678"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8145304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="841" mass="96543" checksum="9C5A51C6CB69C9A5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG85</accession>
    <name>A0A5N6TG85_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">BDV25DRAFT_164911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="ML742358">
        <property type="protein sequence ID" value="KAE8145327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG85"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="39"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="510" mass="55265" checksum="A105E1ED3360CE60" modified="2020-04-22" version="1">MRPITRSALRPYVCPSCRSSGSLGRRRFGSKSNESPDVYDVVCVGGGPAGLGLLAALRASPVTSKLKVALIETQDLQKARTWNLDSTQYSNRVSSLTPSSVSFLQRIGAWDHLDTDRAQKYQEMQVWDGETDSRITFDWSMETSPFEDLRTVATMTENANLVRALLSRISESGDENLSIFSNTTVSSIENGTAQPDGPDLSAWPVLSLAPSGSAQSHAPARIAARLLVGADGINSPVRRFADIGTEGWDYNRNGVVATLSLAEPDSTPFPIGTRTAYQRFLPSLGGPIALLPLPNNHATLVWSTTAENAAYLKSLSPKAFIAMVNAAFRLAMTDLKYMMRMERPATATSDYEDSHESELTWRLQHTPQADHIPPMATGVQEGSVAAFPLRFRHASTYISPRVALVGDAAHVIHPLAGQGLNLGIGDVASLSKTIEYAVDHGMDVGDLLTLERYTAERWATNAKIGGVCDMLHKLYNVPGQGPVAWGRSLGLEVINRLPFVKGLLMKNAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGZ3</accession>
    <name>A0A5N6TGZ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_144707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="ML742351">
        <property type="protein sequence ID" value="KAE8145389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGZ3"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="42070" checksum="C99E624084BFAAA3" modified="2020-04-22" version="1">MGNESSTLVDEGTLPSVLEARNMEAVAKYINAKKDCRIVVMVGAGISTSAGIPDFRSPDTGIYANLAHLDLPDPESVFDINFFRENPRPFYALARELAPGQYRPTIAHSFIKLLYDKGLLMKHFTQNIDCLERLAGVPGEMIIEAHGSFANQHCIDCKAEYPEKLMKQAIDKGEVPQCLQCNGLVKPDIVFFGESLPGDFFDNRTLPEQADLCIVMGTSLSVQPFASLPAFCRDGAPRILINMERVGGMGSRPDDVLLLGDCDTGVRKFARALGWEQELEALWESTKPDQKARDAETVPQTRDERLRDEVERLTQEVDRTLGISDAYQQRIRQKLEPVAKETADHEPSEVRNGDAEQWSPGGLAHVFPHMARENKPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THQ1</accession>
    <name>A0A5N6THQ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_170397</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="ML742322">
        <property type="protein sequence ID" value="KAE8145669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THQ1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024877565" description="glucose oxidase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8145669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="605" mass="65870" checksum="01C13953CE3D7790" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THZ1</accession>
    <name>A0A5N6THZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742319">
        <property type="protein sequence ID" value="KAE8145711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THZ1"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="566" mass="63307" checksum="21999330DC3AF3A3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIE4</accession>
    <name>A0A5N6TIE4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="11" type="ORF">BDV25DRAFT_163037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742283">
        <property type="protein sequence ID" value="KAE8146148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIE4"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="10">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="412" mass="45292" checksum="BD8614B76B1ECDA3" modified="2020-04-22" version="1">MAPSPCQNCQNNRAVIIRPKNRQKLCRTCFLNVFETEVHETITSTSLFYPGERVAIGASGGKDSTVLASVLKTLNERHNYGLQLCLLSIDEGIKGYRDDSLETVKRNAQQYEMPLEIVGYGELYGWTMDQVVAQVGKKGNCTYCGVFRRQALDRGAARLGIKHVVTGHNADDVAETVMMNLLRGDLPRLSRGTSIVTDSAASDIKRSKPLKYAYEKEIVLYAHHKQLDYFSTECIYSPEAFRGSARTLIKDLEKIRPSSILDIVKSGEDMAELVPAEVKGTSCARGAEDESAGGCGSQNGRSRGGEMAEMEKRLAADEAAESRETEIKLPVQAAPKQTKSKGSNQKVIKTQTMGKCERCGYISSQKVCKACALLEGLNRNRPKTAIEVGVSLEDEESSTTLMRQMERVQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIF5</accession>
    <name>A0A5N6TIF5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_163056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742283">
        <property type="protein sequence ID" value="KAE8146158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIF5"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="607" mass="68033" checksum="9EDF40DEDE0A192A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIP0</accession>
    <name>A0A5N6TIP0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_54350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742277">
        <property type="protein sequence ID" value="KAE8146234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIP0"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="136" mass="15321" checksum="1F8BA08F9E568584" modified="2020-04-22" version="1">MGPPRRKVLATAEETLTPPDELQQGQQIARVIKATGNNIYAVELPSKDTILVELPSRFRSTIWMKRGSYVVIDTNALEGRDNKLVGEIINIVRDEKAWRKAPFWPKQFVKQPVAVSDDEEEESRVGKMPSSDESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIV0</accession>
    <name>A0A5N6TIV0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742273">
        <property type="protein sequence ID" value="KAE8146283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIV0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="337" mass="39220" checksum="A5BE3682734C10FC" modified="2020-04-22" version="1">MEHIAVDPDFDSIAAGYGTDPEDFQSDTTSITSSIAKGRFENGRRYQSLKEDDYWGPSDAQQFEAFEIGHMMFRVLDHNQPNPLFRAPIKESPKNILDIGTGQGNWAIDVADLYPDTTVRGVDMFPPPVIWVPPNCIFEVDDVLREWTWQEPFDFIHMRLMYGAFTSEGWDQLYKQAYDALEPGGWIEQMELDVRVYSDDGSLKQEHQLHGWGNMFVECSERAGRSLRTHETMRDAIQRAGFVDVHEEKYKIPIGPWPKDKSLREVGHLQYAHWSTALEGWAMWLLTHFGEPEPWTKKQVHEYLSKVRMELKDPHIHCYEPATRVWARKPTLEEMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ26</accession>
    <name>A0A5N6TJ26_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_51985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742267">
        <property type="protein sequence ID" value="KAE8146378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ26"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="542" mass="59978" checksum="F6798463C26444B0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ89</accession>
    <name>A0A5N6TJ89_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRP40, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_55451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742283">
        <property type="protein sequence ID" value="KAE8146159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ89"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="368"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="43715" checksum="C81B483B7BCED360" modified="2020-04-22" version="1">MAGHKEKKASPAKMTQDKKASVPPQLVASIESFLTEFGFSKTSQAFVKEQASKSISKSDIKDAPSLLQIFQNWTSQADNAKSSEESASSGSSESSSSSEDSDSSSDESSDSDVEMNDAPKAQPKKQSKSSSPSSSSSSSSSSSSSSSSGSESDADDESEEEAAPAKPQGTKRKAESDSSSSESESESDKAPQNKKTKVSAKEDSSSSDSSSSDSDSSSGSESESNDDNDASSDSSSDSDSSDSEEDTKKDDKKALKAAKKTPLPPSDSSSSDSSSSDSSSDSDSDSSDDSSKSEKSAKKSPSAESSSSSGTLENSDSNAQKSASSAPETGSSSASPAPDNGPAQKRHTGARPTPLALLSEQPYDHHPSNTYVPYAYAEKAWKDLSITRGKGFTKEKNKKKRGSYRGGPIDISGGKSFKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK75</accession>
    <name>A0A5N6TK75_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_161923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742245">
        <property type="protein sequence ID" value="KAE8146737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK75"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="119" mass="13399" checksum="AA5B11A423B6DF39" modified="2020-04-22" version="1">MSAQNSAGIQTLLDAEREAQKIVQQAREYRTKRIRDAKSEAQKEIEEYKGQKEQEFKKFEAEHSSGYKKAEEDANKEAEVKLQEIQEAGNSKGTKVIDDLITALTDVKPEASEKIVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLC0</accession>
    <name>A0A5N6TLC0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_160990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742223">
        <property type="protein sequence ID" value="KAE8147138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLC0"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="446" mass="49417" checksum="D94F53536E891015" modified="2020-04-22" version="1">MNMNGSKVRDGRDSPQPGPFGYSFLSPMDTPYDPAPAPPPGPALLDDNESNMLDNFFTTMNTNNFSNDFWLQTQPNKSLGPASFEWSDELPPTFEGSTTSLSQPPIPHHGMDKSGMGIFPNHPNPDIFAAASMLYQNGMNSSGLNPTFSPHNFGSFPDMDFNNSSVNGRARNQPQPMSSKQPNAFSTARVPVAYHTPEMLFDVRDPISPEQQATAKVRPLHWGSDVSFMDQGYVAPPDQPNVEEQTHELLRHLESLEPQHSAANTRAPSPERIPEGPGAPWAGSIATRPLNDLRRDYRGSIEDLSQPKKRQKTLVKEEDGEDSDGGISQARSRRSKSTSYGKGRRMSTETIRKSKLQQGSKPARENLTEEQKRSNHILSEQKRRNLIRQGFDDLCTLVPGLKGGGFSKSAMLTQAADWLEEILRGNEILKAQLAEMKTMNGLVMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLI7</accession>
    <name>A0A5N6TLI7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742223">
        <property type="protein sequence ID" value="KAE8147150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLI7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="19403" checksum="098AA17193E031D8" modified="2020-04-22" version="1">MFKYKCFRHNTTPKHSTTEAIGTYYLGPILQVFMFFAGLISPMMDRLWGLFIPFYIPSYAQSIGLTDQSNNITAILNALAASLFGPLQPETTPTNSPPSTASEILMLIWIRISKPDMLVFSVLSASPGQLSGSSDHYRYGGGMKLGRIWYGTGCVQSDRSEWDTYYRCDDLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLV0</accession>
    <name>A0A5N6TLV0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLV0"/>
    <dbReference type="OrthoDB" id="4445002at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29990" checksum="9486988D3F457E95" modified="2020-04-22" version="1">MPTNQTSTPTSSTTTFTTITSSTTDHPLSLRPHLTRWVSRKMSRPEIQKHHHHHHQQQEQEQQQQQHQPLRTDIDSSEERVNDSYAAYCRAFTEGRTHSPSTTFQNHSTFQGGQYSFPDFNQNTGEESPRGSRVRVMDRVEGTASTPLDEGLFDFRPIGYYGFSPLQGPGVTPPPQIMTPDMYTQRLERETSLDRSVDSDLASVHRRVGRESFDQSRPQKKGQQTRGQQTREQQKKPQRKRGFLAPLRSLWLQIRSRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLV1</accession>
    <name>A0A5N6TLV1_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_132178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLV1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="36"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="536" mass="57418" checksum="FB66B4EB3625E84C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM96</accession>
    <name>A0A5N6TM96_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_160839</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742219">
        <property type="protein sequence ID" value="KAE8147211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM96"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="45110" checksum="2FED79C923DFEBC6" modified="2020-04-22" version="1">MRRVVVTGLGAVTPLGVGIRRTWKRLLDGHCGIVNVNHRDSRFTDLPCQIAAVVPNGTRQEGGWTPSEWLSRDEERKMARFAQYALAASEEALEDADWKPTSSEQKEMTGICLGSGIGNFDEIYNTVVAYDKGGYRKVSPLFVPKLLINLGAGHISMKYGLMGPNHSATTACTTGAHSIGDAARFIAFGDATVMLAGGAESCIHPLAIGGFARARSLATSYNDSPEKASRPFDADREGFVVGEGAAMVVLEELAHAKARGARIYAELCGYGCSGDANHMTAPKENGEGAFMAMKKAIKSAGLSPSSIDYVNAHGTSTVVGDAAENAAIKALLLGPGGKHTARDVNISSTKGAVGHLLGGAGAVEALFTVLAIHENTMPPTINLERLAEGFDCNYAPKQAQDRRIDVALTNSFGFGGTNSSLCFSKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMK8</accession>
    <name>A0A5N6TMK8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_168980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742201">
        <property type="protein sequence ID" value="KAE8147568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMK8"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="884" mass="99027" checksum="A536D6A7F59318B3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMU5</accession>
    <name>A0A5N6TMU5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMU5"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="346" mass="37086" checksum="387A66D883E389D6" modified="2020-04-22" version="1">MAPTTMKQWIIDRPDQNMQGTRFEEVPLPSVGDYGVLVKFEAAALNYRDAAIAKGTFPFAHKYPIVPVSDGAGVVVETGSQVREFKKGDSVITVFNQGHQYGGIDPYAASTGVGGTVDGCFRQFGVYNETGLVKAPKNLSALESSTLPGAALTSWNALYGLKPIKPGQWVLVQGTGGVAVSGLQLAKAAGAAVIATTSSEEKAQKLRDLGADHVINYRDVPNWGEVARQLTPDQAGVDYILDIGGTDTLDQSLKCIKMEGIINLIGFLGASDQPQPRFADALSHICTVRGLFVGSRAMLKDMVQAFEANDIRPAIDPKIFSLEQGKDALEYLAARKHFSKVVIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMU6</accession>
    <name>A0A5N6TMU6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_142535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742196">
        <property type="protein sequence ID" value="KAE8147668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMU6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="123" mass="13564" checksum="16C1B229017C31E9" modified="2020-04-22" version="1">MRAPQPTLARWPSRLAMTNPPPYYDVERGDGIRLETYNSRSGSKRAHRMETSSLRTVQEGKLSCPCASQSGTRDTINTEEPPPSKASQCARASLVFFVFIGSLCGFIAASVVISKHYNLTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNN1</accession>
    <name>A0A5N6TNN1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_159366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNN1"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="123" mass="13434" checksum="BA8055CA5C8F9594" modified="2020-04-22" version="1">MSSQPLLQTAPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGGLAVGLLNFGDRVGRISAGLFTVIAMAAMIYALCTFHWRAASIRKRGQSGIDDRFGPTVLALALLAAVIVNFILRITEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP44</accession>
    <name>A0A5N6TP44_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742174">
        <property type="protein sequence ID" value="KAE8148126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP44"/>
    <dbReference type="OrthoDB" id="4501861at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="266" mass="29375" checksum="413A7557C6D9C37F" modified="2020-04-22" version="1">MAEPARKSLKIAKDAKIGCSSLLHISTHHDSMSGAETSGDDLPHKLRSPVALLPRLKSDDAPESDGGRLRTPGENSNRIQDNIPNQGADNLHASKSDSGQHDIYKGETTDDDTSLESALSTANITVISDQTQGKDSNPEKPAVKKRYTKEEVEALGAIIYREADAALRGLVDSESEDSHVSEESGSMACAGPIEQGNTVNPHDSCLEPRHIERDMSRPPLSECDHFQDYVNNLLAEYYNQSDDNIDDFGLSTLRRRPLREWYQDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPP8</accession>
    <name>A0A5N6TPP8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="810" mass="89706" checksum="03BA18F067163FDB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQU0</accession>
    <name>A0A5N6TQU0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQU0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="54" mass="6108" checksum="91F6B551AFEE3124" modified="2020-04-22" version="1">MIVISGPTPGLVVPCLRVLFCCPFWLVYIDRKSRLAFNHSDISLMWLESLLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQV9</accession>
    <name>A0A5N6TQV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_168251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQV9"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="305" mass="33600" checksum="DA1B13A20DAF10F0" modified="2020-04-22" version="1">MSKVLAVFGATGNQGGSVIRSILADPVLSKEWKIRGITRDPSKPTAAKLADQGVELVSADMSSIEQALPAVTGADAVFLVTNFWESMNRETEIAQGKAVTDACKQAGVKHLIFSSLRNVTEISNGRLPNVSHFDGKAEIESYIRQSGVPATFVLAGLYMGNFFQFFNKQGDTYTLAWPVDLDKAQVPLFDVVNDTGKFVKAAIKHYPTALNQRILAATDYYTPRRIVEEFSQVTGYKVQAMQIPVDVFKSFLPPPVAQEMLENILLLENPGYYAGESLSPSHDLLDAEDKPTQWKEFAAQNKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRC9</accession>
    <name>A0A5N6TRC9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_157310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742142">
        <property type="protein sequence ID" value="KAE8148903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRC9"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="693" mass="77375" checksum="BD59E7C7A93F38D6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS30</accession>
    <name>A0A5N6TS30_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742132">
        <property type="protein sequence ID" value="KAE8149166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS30"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="53" mass="5859" checksum="2AADB5CD8EE5AFB3" modified="2020-04-22" version="1">MKQNKAFYLWGLLVVTTIEQPSVPFLILPLYLAIAPPQSGRDIPECANCSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSG5</accession>
    <name>A0A5N6TSG5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_167924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742128">
        <property type="protein sequence ID" value="KAE8149295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSG5"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000050">
        <property type="entry name" value="DNA mismatch repair protein Msh5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8149295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="914" mass="101625" checksum="F4BAE3A528473DC7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSQ3</accession>
    <name>A0A5N6TSQ3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSQ3"/>
    <dbReference type="OrthoDB" id="3001700at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="133" mass="15389" checksum="BFAA445D3E7913DD" modified="2020-04-22" version="1">MNPFNPTQPQHEQETQQKDQQSYTDWLRTQYNVQYERWYPWLEDQYLKWFGKGDNKASYVTKDTLNKSKVTGVDQVDQLQDDVHNLVGNQLGDNGLLAPVGKMMSKEGINRAERQGRDEDGKYGFGGWGISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSR8</accession>
    <name>A0A5N6TSR8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_6322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742132">
        <property type="protein sequence ID" value="KAE8149179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSR8"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="37"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="414" mass="45826" checksum="C96B2139E051C71E" modified="2020-04-22" version="1">MSVSLPKDLRDSMRQALRRRELKSARRRLTVLSESSVDFSSNDFLSLSTSPAFRTRFLAHLQQAPAFYPFASGGSRLLDGNSTYAEDLEKFIADFHRAPNGLLFNSGFDANVGILSCVPQPGDVIVHDELIHASAREGMRLSRAGKRVKFAHSSPESLEEVLKSQIKADPLIANGTRNVFIVVESVYSMDGDIAPLREFLQVVDTLLPQGNGYFIVDEAHATGAFGPRGAGVVQELGVEDRIFIRVHTFGKALASHGAIVLCCSDTRDYLINYARSLIYTTALGFPFLACIRTAYELLSEGETKPLQRKLQQLIMYLRTRLGDLGSWDPSVFEVDHFPGSPIFSLRSPLPRQLAATCQKQGFIVRAIMAPTVPSGKERVRVCLHAGNTMEQIDGLVDTVQQWLNQATEKRVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV3</accession>
    <name>A0A5N6TSV3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_156892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="ML742133">
        <property type="protein sequence ID" value="KAE8149151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSV3"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="427" mass="46745" checksum="E4C7D2B77C14D071" modified="2020-04-22" version="1">MPSSAKSDSSKTQKLDNDSFVAFDHAAAGHEGVRCTTSGSFIAKPCTPAEVSFYESCALHPAFIEFIPTYIGTLTSADEQQPFALASLQQGATILPSSDTSEVATATPTSGTDVPQESTTKEEEWVPSGGKKIDTELSIVLENVASGFKRPNVVDVKLGARLWADDAPLSKRAKLDTVSKDTTSSSLGYRIAGMKVWTGVNGENDEGSKTDPYAIKYEGAEGAKGEVIEKEGYRRYDKWYGRSFTDENIKEGFETFLAGAKAGATDRSKLIARRLADQLKLLQQVLESEESRMYSSSILVVYEGDSEAMENALEEEKKAKENPKEESEDEDEDFELEVQPDGSYQIIYAPLDKDDGPHPVVPNSIEPESAQLTDLEDEEEEEEAPKVHDLRMIDFAHASWVPGQGPDENVLKGVRNLAKMFDELAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT24</accession>
    <name>A0A5N6TT24_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF967 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_125255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT24"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.150:FF:000005">
        <property type="entry name" value="UPF0303 protein Ping_1243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20475" checksum="CD8A632DB38A66CA" modified="2020-04-22" version="1">MEVKPLAPASKDTLDLTAQETSSAVFFPTFTSTTAWSLGQALRSRILSLPPDQRKPALISIALTGGSEPHVVFQCATEPGTMPDNEIWVRRKRNVVLRWGVSSWLMRNKMLSSTGLGGGEVEAAFVRKHALTSTGGGGSADDFAIHGGAFPVRVKNVDGIVGVVVVSGLKQEDDHQVVLEVIRDFIHQGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTB3</accession>
    <name>A0A5N6TTB3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_156586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742127">
        <property type="protein sequence ID" value="KAE8149311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTB3"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000687">
        <property type="entry name" value="54S ribosomal protein L23, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="199" mass="23297" checksum="191F62D722C79D89" modified="2020-04-22" version="1">MVRQFSKFPKKPATWVGPSAPLTQRKQVFLPDFTIALIRTPFLPPRYASFYVPLNFNKLDMRDYLQRLYGVNVLSVRSYVEQQKVTRLRPKDKYGYGKLRRPVSKKKMTVEMKQPFVWPDLPDMEKFEREQYFKAAKYQTDLQDQQRPDAGMKAKKDEREAFSEDAKKLLDGSKPWRPTWQALGLSYDRSGLGKSSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTC8</accession>
    <name>A0A5N6TTC8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_124930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742118">
        <property type="protein sequence ID" value="KAE8149616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTC8"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="301"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="534"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8149616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65825" checksum="4A5B401F2208E331" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTK9</accession>
    <name>A0A5N6TTK9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BDV25DRAFT_155831</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8149698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin cortical patch localization"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
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    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="50"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="23">
        <location>
            <begin position="787"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="1083"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="19">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="955"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1134"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1018"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1211"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1233"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAE8149698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1260" mass="138398" checksum="6AE2D95D253CBB5E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTL6</accession>
    <name>A0A5N6TTL6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140563</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024872749" description="Hydrophobic surface binding protein A-domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="21745" checksum="672F87DEC8EEC082" modified="2020-04-22" version="1">MKAAYILSALASTAIAAPLNLPILGNLNLPVLSNLDELLGTNLPVISDLGGLNNVLGGALGSLDGTSGLPLGDLLGGVTGILGGVTSNAPTGTSGATPSVSATPSASGSSGKLLQDLAPKVNDVLIVTGPNAKQLLIKLSPEVTSLVSGLGLPGLGVPLGGIVGSASSVGDLVTALGPQVEGLVTVVAQGVGALVIQLSPEVAGLVSGLGLPGVGVPLGNVLATVGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU29</accession>
    <name>A0A5N6TU29_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_172660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU29"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="103"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="566" mass="64671" checksum="ACEBDD87CC7CCB26" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUE1</accession>
    <name>A0A5N6TUE1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_155246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8149986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUE1"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="122"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="583" mass="64697" checksum="E60E2C6AEDCC154F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUU0</accession>
    <name>A0A5N6TUU0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUU0"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="248" mass="27731" checksum="A5C26448FE728DF5" modified="2020-04-22" version="1">MKFLCLPGSYISAKTFQTQLKPLCDCLSRDGTTNFVFTQGDIPVSPPEEFEGFFGPRPNYAFVKPDDIGAIMFNMRNFPKRETPEDTMRLALKMAGQPTFSDIVPVMDRLIEILDTEGDIDGVLGYSEGAEIAASLLIEETRRQKEYGREPRIKYAVFIGGWPPIHPSIRRVVLADEVGEIIKIPTCHVVGAADPYIDGSMALYNVCDPDQADLFDHGGGHIIPREKNTVQDLVNMIWETIEGMEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV25</accession>
    <name>A0A5N6TV25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_114654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV25"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="53207" checksum="6F11C0CEA0A6C957" modified="2020-04-22" version="1">MGVPRSNGCLLCVQRRVKCDEKLPGCARCETYGKPCPGYDRGFKFVVGKPYRSRRPPRSTAPELRGLSDDASGSKSQYTTKDDSRAVVRRGNLSDLPSAHLQILQGLDILVDDILQPFSTSSAYTPSRWFQYLPSVYGKNKTLDCAIKCFSAHHIGTMTGNDRPVLYARRTYVEALNRLQRSLCNKIESLSSEILCAVLLLCLYELFTNKNDSTSWMKHAKGLGQFIQIRGCHRYQDTFDHAMLHASRGIIVMHSVFANERCFLNSDDWHFIMRNRPDTSLPANFFSLVEDMFAYLTAMPSLVHEFLRIIKADPATPEAKLGRSKLLEQALHMQQNLLVWYNTFTNTVPLPTETLSATGDTLHPIVYYFPNVDIATIYCAYYSYMALIHAILQLCDYPGDHTAMVVYFRDQICKSVEYNSRGILGPYRLGFHLHVVYELGDPVTKAWVKSRLQDLSRNYAALLPENFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVC7</accession>
    <name>A0A5N6TVC7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_129899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVC7"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="709"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="976" mass="109601" checksum="15531972B23F31FA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVC8</accession>
    <name>A0A5N6TVC8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_114691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVC8"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="34951" checksum="737946096D236C83" modified="2020-04-22" version="1">MVDDKFIGLALAVLASVAIGSSYVITKKGLIHAAEKYGFDGEGFEYLRSPVWWCGTIILVSGELMNTAAYAFAPAVLVTPLGALSVLIGALLGTYFLKENMQVLGRLGCATCLLGSVLLVLHAPGDRDIQTIEEILHLAIQPLFIIYCVFVTSFSSFMIYKVAPRKGRTNPMIYISICSTVGSISVMSVKAFGIAVKLTFAGDNQFTHASTYVFTLVLVVTTLTQMNYLNKAMGEFPASLVNALYYVAFTTCTLTASIIFYQGLNTSDWTSIISMICGFLLNFTGISLLTLSKTAQEGRPESVRDVSLRSFDMSRGRYDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVS9</accession>
    <name>A0A5N6TVS9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_154306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVS9"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="44686" checksum="1698208721435994" modified="2020-04-22" version="1">MSDELPVIIIGAGISGLILAQYLKSQGVPFQVFERDSAVDARSGGWGLTLHWALPALRQLLPDDLVARLPETYVNKEAAARGDAGRYQFFDLKSGDALYSVPSTERIRVSRVRLRQLLTTGIEVQWNKAMKDIESTPDAVTATFEDGTATTGRLLLSCDGSRSRSRQILYPNGHEMNTLPVQLLGAATYYSAEELKGAEKIDPFIFQGSHPDTNVYLFFSFLDTPNNFEDSTDKYHCQLVVSWAESKNIDIPPTSAERIALLKSLTENWVDPFRSLVHQLPDDTDALSIKIADWIFRPGHRESHPRVVLVGDSAHTMTMFRGEGANNAIVDVQDLVKNVDFTSPRTFELETLNTSLQAFESDIFARAEPSVLSSRQACLDAHDFQAILNGSPLVSKRILKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW18</accession>
    <name>A0A5N6TW18_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Muramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW18"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33309" checksum="D9E487B81D3DE656" modified="2020-04-22" version="1">MNATKLLRPVYTQLRRSTLCSFRSVPRLPTITNYTSHPAKRLHFHSFHTTMSTPDDDRPLRPSKRDPTVETEQNSADELERLLQKDRFKTWGFVIYRCTYESDSDWEKFMSRFLYHITDNLEFYNGLDLLDNFAPTVFEDRSFDGADTASLRKHFQEWAVTAPQEEQGADRSRVPDAGRYRFFIMVDQEALESVLNAPDPASVNKTGFVRLVNGLWKPDEPDEEELAELGVEGLEEEEPLEGCTLEDVGWMKVLYDEAETWAYLNMGDTVHWSTYYVRPPLIQKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW20</accession>
    <name>A0A5N6TW20_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_154347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW20"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="677" mass="76160" checksum="92ADFB4466E48F76" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWD5</accession>
    <name>A0A5N6TWD5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWD5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="66" mass="7627" checksum="491D011DF388D235" modified="2020-04-22" version="1">MRKPFPFLLFIYPILILGFCAAYILGILGICMQGGCDWFYFFFLLTLYGVARYGGIWGEMEWRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX01</accession>
    <name>A0A5N6TX01_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_129172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX01"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025056235" evidence="7">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="493" mass="51861" checksum="FFFB7D12596DDE0A" modified="2020-04-22" version="1">MLRGLLLTSIATGIVQAQSYSGCHRHGSVEYCYGADGEETPITTHAQSTTNAQITSVPATTTSSAQSSAVTGCHNHGDDVYCIDGDGHEVQVSLAATPTGELPAQYTGCHSHGSSQYCLDADGNDVQILEEGETTDGSDSESSDSTGGMNCHFHAGVEHCVGAGESEGSSTKSCGVQSRDYDMPLRIGTLFVVLVTSAIGVFLPMLLIKLPLPNLNSIASTIIKQFGTGVILSTAFVHLYTHATLMFANDCLGELEYEATTSAVVMAGIFLSFLTEYIGHRIIVARGSKACAETCDDTPETNRSTSSKEGTQPQAMQLAHLGHNHGADPTKPNTKLSVMVMEAGVIFHSILIGLTLVVAGDSFYKTLLVVIVFHQFFEGLALGARIALLPGRIFPSKTIMAGTFALITPIGMAIGMGVLHSFNGNERSTLIALGTLDALSAGILVWVGVVDMWARDWVIEGGDMIDAPVMRVLMGGLALVAGMVLMGVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX36</accession>
    <name>A0A5N6TX36_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_153554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX36"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000447">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000027">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="536" mass="58167" checksum="212C8329EBDA2A01" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXG1</accession>
    <name>A0A5N6TXG1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_153360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXG1"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="164"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="296"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="415" mass="45179" checksum="98758589152B5D7C" modified="2020-04-22" version="1">MAESSFSGANPYLKVGTKDDRSGAFMKISEEDEWEVTSPTDPTFRTANSAAASSSTGNNTFTNSAFGEGGGSGGIRFRRSPFGTAPDEEDEEHDDFSGHPEGARPIGNLNEGFPNNYALGRRTSVSAESLNPTSAGSDSWVPPHHPKTEEQVTRLKTAVSGNFLFSHLDDDQFKTVVDALVEKPIPAKDIKVISQGDAGDYFYIVEDGHFDVYIHPSGSVQSGPDGMGNKAGSIGPGGSFGELALMYNAPRAATIVSTDSKSTLWALDRITFRRILMDSAFQRRRMYEAFLEEVPLLSSLKPYERSKIADALDTMKYPAGSTIITEGDPGDAFYLLESGEAEAFKSEVDEPVKFYKRGDYFGELALLDDKPRAASIIAKTEVKVAKLGRDGFKRLLGPVEEIMRRAEYQTKPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXK5</accession>
    <name>A0A5N6TXK5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXK5"/>
    <dbReference type="OrthoDB" id="4492263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024946802" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="59" mass="6123" checksum="785C8413CA3EA47E" modified="2020-04-22" version="1">MLRLLTAIVLLVSVASAAPSAACIQMCRQEKPDCASGEVASGVEGCWGCCQPVEVDIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXV5</accession>
    <name>A0A5N6TXV5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_98747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXV5"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="307"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="437" mass="48541" checksum="95B80EB916CA8E3E" modified="2020-04-22" version="1">MLQVPMREHTNVASTKAIILVGGPSRGTRFRPLSLDVPKPLFEVAGHPIIYHGLKALAKIPDIRDVYLVGYYDETVFRDFIKDSVKEFPQFRIQYLREYTSLGTAGGLYHFRDAILKGKPERIFVLNADVCCSFPLGEMLRLFEEKDAEAVILGTRVNNDAATNFGCIVSDSHTKRVLHYVEKPESHISNLINCGVYLFATECIFPSIRTAIKRRTTRPRLVSYPSSEHLESSFIAAEEDSEKSEVLRLEQDILSDLADSNRFFVHETKDFWRQIKTAGSAVPANALYLQKAFQAQSEELTPPSATIVPPVYIHPLAEVDPTAKLGPNVSIGPRAVVGAGARVKDSIVLEDAEIKHDACVMHSIIGWSSRVGAWARVEGTPIPMASHSTSIVKHGIKVQSITILGKECAVGDEVRVQNCVCLPYKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY60</accession>
    <name>A0A5N6TY60_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_152991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY60"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="736" mass="82177" checksum="4B9FB2D9F9A772DA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYZ1</accession>
    <name>A0A5N6TYZ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYZ1"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="318" mass="37150" checksum="27A82804EDFCC909" modified="2020-04-22" version="1">MANKYSLSRIIRLPRRLSLREAKNEQRENEWHALERLFKKLYDSSDSVIPADLLQSLPINLQPLDLETDDIPNTDRFFRPWSVVKLETHVRSTEVTEANEDVAVVESILKDDTPRYKAMGGCKTWEWASELCYRLMWEVAVAPRKGTEGDLQTIKTVYGWRCLPYLPDDYRFQPWLCSQQGSWYPKYYFYIPGNSPHIKICMYHNADGVSGQILREELLAMLAAMISRLGQNKFRKHLIIPVCTPNIFSQLMLFSFVGKQHGRIFLAHFDGKGLVVRMSELYPFMAGEEDFHQNLFLFTRYLAGEIDPRGETTRFRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZD7</accession>
    <name>A0A5N6TZD7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_138661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZD7"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF32">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="283" mass="31143" checksum="1EBA2A456C3BC100" modified="2020-04-22" version="1">MAESIYFYNPSLAAAILFTVLYLVPFLYHLYISFIAPYTGKYHHTGYFVPILIGAATEVGAYAVRAASVKTPDDVGLYATSATLIVVAPVLVCASLYILIGKLIRSSGRDSSPETETKEPPLLFERFSPSWIPRVFVTSDIVSFLTQAAGSGIASSNDWQGKEKDVGVGILIAGLALQLFTFAFFLVVVVWFDVRVFSSSSAREGSAAGVRMVLNGIYVAGSLIMVRLIYRVIEFSMGMDTYTWTHEWPLYVLEAVPMLFAMLALGWYHPARWLAPGFGARMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0A7</accession>
    <name>A0A5N6U0A7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_138279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0A7"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="344"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="670" mass="75822" checksum="356A1C66D867CD4B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0I8</accession>
    <name>A0A5N6U0I8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_138181</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0I8"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="335"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="629"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="716"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="838" mass="93621" checksum="88F27955A388C684" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0Z9</accession>
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        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BDV25DRAFT_170593</name>
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    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0Z9"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="667"/>
            <end position="908"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114117" checksum="C5656FF9AA816250" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U145</accession>
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        <submittedName>
            <fullName evidence="7">Mss4-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BDV25DRAFT_137918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="285" mass="31860" checksum="2EEBA985CB3172E9" modified="2020-04-22" version="1">MPTGTCFCGDVKYEFSQDQMQKAICHCLSCRKITGSTYTTNFIIPESNFTLTSGSLRDCTRPHECGMDLSVFFCGGCGSTIYKKATGDMFKGVIVLLVGTVDNAEGVEKAVPDREFYVKHRGDWLQPVQGAVQDAASKPTSKREQPRNPNQHDDNNGRGPTGDPPEPPPLLNKPVLIPKKELKKLLDSKGREMYERLKNGLTSNRQRTVWSGGNHRIDPAHSIQGNSNLKPWNLHVQREAASTTSRDLKDKFGTHAKLIWDVFNIANPPSFQEWCSRLLSLYNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U161</accession>
    <name>A0A5N6U161_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U161"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046503">
        <property type="term" value="P:glycerolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="31503" checksum="9C674AC1F831CA51" modified="2020-04-22" version="1">MQTHDIGASSLEVDGASLHYELIGAGPLLLLMPGANGTGFLYQPLAAALSSQFEVVVYDRRGFGQSPILEAEDPDSPTLLRTQTVDASRLIEHLSPGRPVTVFACSGSGVMGIDLLQSRPDLVYQLVLHEPLLIAPLPEPLKSQIIAEYTNTILEYGKYSSSRLHRALMPLMQSKRDQFRLGQTHQFSRLQTLPGDHTGRFYQHELPQIFDYRPDPGILRRYRERIVLTKGAECAPRLSIASVHTLAQALDIPTVIVPGGHTSYVTDVEPFTKHVVSALRCATAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U231</accession>
    <name>A0A5N6U231_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_150767</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U231"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8152628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="53902" checksum="D5E535DD78272870" modified="2020-04-22" version="1">MYEFGGPLGAAAITVGLPILLYFFAFACNDISGCPAPLLLDPRTLSWKVLRSQIGWTHNAIWHLVSWKVTGVVLAYYLLSLLLWKFLPSHNAHGTKLVHHGRPLEYSFNSFSSTIVQLAFCAAGTYMQGAEFYVWTYITDNYVQILTTNTMIASALSVYVYILSFSVATKYPNSELRELAAGGNTGNPVYDFFIGRELNPRVNLPVFGEIDIKTWCEMRPGLTGWVLLNLAFMAKQYRIYGFLSDSIIFTTFVQAFYVLDGQWNEPGILTMIDITTDGFGFMLSFGDLVWVPFLYSTQCRYLSVYPLHLGWSGIASVSAVFALGLYIFRAANTQKNMFRTKPDDPSVAGLSYIQTKRGTRLLTAGWWGMSRHINYFGDWLQALPFSLPTGLAGYTILTASDAAIVSADFEMLDGRGVIQDGAKGWGAIFTYFYVLYFAILLMHRERRDDAMCAKKYGEDWEEYRRKVKWRILPWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2C1</accession>
    <name>A0A5N6U2C1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_151230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2C1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="106" mass="12298" checksum="F5ABFA65F990DBB0" modified="2020-04-22" version="1">MSYSTLARQVVVIRKRHLHLVAFVRWSSQAPFEPHGECKPWVIRTMRGIFSCRGRIKHTMLHDLVTRLLLSVCSFVSSSRQYILRIGPVSFVLAMIRLVMAWYPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3F8</accession>
    <name>A0A5N6U3F8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_137588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3F8"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406:SF1">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE ALPHA CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE, ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="290" mass="31609" checksum="D3FCA55309F872C6" modified="2020-04-22" version="1">MEQIRGAFTRAKNQKRAALVAYITAGYPTIEKTVDILLGLEDGGADIIELGVPFTDPTADGVVIQKANSIPLANGVTISTVIDIVHESKAHGLRAPILLLGYYNSFIHYGGQRLMKVSKNAGVSGFVIPDLPFEESVCFRNLCEQYSLSYVPVISPVSSASRIKALCHIANSFIYVVSRMGVTGSTDKLSPDLPQRVDRIHAWSNNTPVALGFGMSKREHFLFVQEIAEACVIGSKIISVVGDAPAGQEARRAEDYLFSVTRRRLRRDSRGAFVGEVSLRSGYGPRPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3I6</accession>
    <name>A0A5N6U3I6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3I6"/>
    <dbReference type="OrthoDB" id="4216327at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024940480" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="182" mass="20150" checksum="3808C2417D08DD8B" modified="2020-04-22" version="1">MKLTGYLSLLALALTANAADCTAPNQQWFSDAAVQMMWSIRAWLCPNAWSQSITAGPDGGWCDAGGGVVGAYWGSWTISGMQSEQQCWDVTEQIINQCMWYDYASTSYNGGSWTYDSIYAGGWFWADTSKTCSHAVKRDVMIENGERVNFTLADGSSQAVDRQVWLEFTPEGINVVRDETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Q9</accession>
    <name>A0A5N6U3Q9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_50307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Q9"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="193" mass="20381" checksum="EE8AF6ADB4B5540C" modified="2020-04-22" version="1">MVFARANFLRASARAIGAASRRPTQQFARRTYASESSHTVQKSSDLPWMIASIGLGVPAAYYLISSGPEKKPHGAHGDHHEAVEEAEQKEEAAPAEESQPQPDRDAEQKVEQAAPSSDQKEGGSFGEPPSNVDQPASRGESGGPASVSGKQEGLSNTDTSNPYVNEPGKSEKGEGETDTAKVKGSVDPARPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U447</accession>
    <name>A0A5N6U447_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U447"/>
    <dbReference type="OrthoDB" id="4259138at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024983152" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36741" checksum="149DAFF7483F5F6B" modified="2020-04-22" version="1">MHVLSGGSLLAVLLFSWPLLVHATIGSIFKLKTEKGERGTCHGQLDTLDTWLSESKALADAALQAFEDAGTESHPHQGIARRYLASYFGLDSASPLEDQTSKRFVIFIKKNSRPIEPPPGYSATIHGSSKCCETMPPCKKGAWTPTWKFRPAATCIRSPLKTWSSTAALCGISTTGSGSATGRIPYWSQDLLSYVFDRNYNGKAFCTAVTENGDRGLAATQDTTNPSTMTFCPFSFEMPTKDKWLGSRMPMGHNIVNVTPRSATSYHETFHLVLGMISTLDFTYDWMVQRKAMRQPNAIPDGFEKRGTTDIQLIRQNPQTAKGTRGIASTQALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4N1</accession>
    <name>A0A5N6U4N1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_24902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4N1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF52">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="467" mass="50267" checksum="F3F4B0BC36207C30" modified="2020-04-22" version="1">MSSIPESALNALTESLNSSTIFTPSSPGYQESIKRWSDTGIKEAGIVIQPTTAEDIRTALLWAQSQKCDFAVKGGGHSVAGTSSSKDGLVIDLSRLNTITVHPDTKTVTAQGGAVWKDVDEAAAKYSLAAVGGTVNHTGVGGLTLGGGYGWLSGQYGLTIDNLLSATVVLADGRIVTASVSENEDLFWGLRGAGYNFGVVVDFTFQGYDQPNPVYAGILSFPPEKLDQVVAELNKLFSESPNPKSGAMLIFAPTPASPSIALNTIVYYNGTLSEGETHYAGLLALNPELNTATSIPYSKLNSLQNEMATYGDRKSFKGLFYRLPLDTAFLRSVLDDLEAVNAKYADLMPAVLLECYDMRKTCSVPFEQTAFANRSAAQNGIVHLRWKDAALDGEFRAWARTLQGRFKEFYYGSGSVEAEGVPQYINYAEPGDAVVGNIYGVNLERLKLVKAKYDPGNVFCKMHPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4P9</accession>
    <name>A0A5N6U4P9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_24195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4P9"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025102241" evidence="1">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="446" mass="48019" checksum="3CC2808CE27A1420" modified="2020-04-22" version="1">MLPFALLFSLMGFSLIAARVAAGSDVSVPTLEALGCGPVCQYAFNHGQAKDRKMFGSDFDVDFYATASKFPDSQPGDLLKFETIDPDSLDVIAGLTAYRFQYTSRDLDGSPVPATGFIGVPYKNLRDGDKYQVIAYAHGTTGVFAGCSPSSTATLHNHTSWSLLVEQGYAIVAPDYAGLGNDHTTHKYLSFPAHANDLYYGMIAARKALPDLFTDEWMSVGHSQGGGAVWKLSESKQVKSGAAGKYMGTVALAPASKVYDMTLVGIDALSHAPDYAKYDLFYLSLALPFAIQRALPDMSRAPFAPALQNRTKIGKMAQACNSALMALGADLKPSDLFTSALQDNSDFQKWQDMVAPANGDKADEPIMIVQGSADTAVWPEITTASWKDSCRHGNEAHLHLYPGMKHSDVVAASSRNWLRFISERFAGKPVTGKCGNVNAESESTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4R7</accession>
    <name>A0A5N6U4R7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4R7"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="61"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="419" mass="44889" checksum="C083BEE93856A6FC" modified="2020-04-22" version="1">MYRLLSDDSLYRINADVIIPGRGDPIPDGAVVWQSNTIRYVGPQSEAPNEYENITTTHVPVVMPGMWDCHIHFLGATAASMDSVPRTPQALAGARSVPDLYATVMSGFTSVREVGGYGCELAQVIAEGRIPGPTVYSSGSPISMTGGHGDVHGMQWDALRDMCAHGLPLEIADGVPECLRAVRKQLRRGARVIKVCASGGVVSAIDDPQHQEFSFEEMKAIVEEAARAKRVVAAHCHGKAGIMNALRAGCRTIEHGSFLDEEAVELMKEKGAILVATRSVIENGLAMRDLFTPGSYKKLLEVADAHQKSYQLAISRGVTIALGTDQFISSDNPMLGYGRSGLEVKYAVEAGLSPLAAIEAVTANGPLTLGDQAPQSGQLREGFDADFIALEADPLNDISLLSDAKNITHIWRNGKLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5D3</accession>
    <name>A0A5N6U5D3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5D3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="59" mass="6542" checksum="2C2F6740D325E0B0" modified="2020-04-22" version="1">MSVDSSYARTRSVSTQRLDIVRDHRLFSTSGLRVSLIIDAISTPSCTYLALALSFLVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5P1</accession>
    <name>A0A5N6U5P1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_149052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5P1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="117" mass="12404" checksum="9ED553B793188463" modified="2020-04-22" version="1">MSLTAILCAVKSATRSSATVSCQLARGESLPPSPWPLTPWAAPAFSRSMCSASAPKLSAINKSLMSTCIPASRHLATKSMARMESPPSKMKDLDQSSELWSMSRTCAAILPSARFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5U3</accession>
    <name>A0A5N6U5U3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_148473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5U3"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="108"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="38037" checksum="B8378184EAE6BECD" modified="2020-04-22" version="1">MSTSASSSRSASRSRQLSSQSHHQSTASYFSYPVTHVVSGLYRRLTDPPSKNNNNSKRNTDSTMTTPNDSYSSSSSQVFTPIRTASPFQPPPLTPLTLTGDPSNLQQQLLTRALAEEIRLLVPARLQLVDTWRLAYSLDRDGASLATLYDNCREMANRSPRAGYVLIIRDASPSAAVFGAYMTDPPHPHTHYFGTGECFLWRASVLPPPSNLALPRDAPPPSEDLLELAGLPPPPSAETTNVGRSTTLRGDKKPAGEDTLAPPLLNGHASGTSTPERIRFKAFPYSGVNDYMMLCETGFLSLGGGDGHYGLWVDSSLEKGVSAGCQTFGNEPLSDEGVKFDIIGVEVWYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U661</accession>
    <name>A0A5N6U661_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_167773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3446576at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33090" checksum="8D9E728A2CE5C2DA" modified="2020-04-22" version="1">MSSIVNTALAAVQTNGQDSYLYYQSGQEIREAHSASGTSWTANASTVASNAASTGSAMTAYYVDRDADFGNRSTIHVVYLDTNAKVVDRVKILANNTWEDGQTTGISKDPVATSMITGGAFNGTTGWAPNGSQWNYYNTPSGNELQITEIRRTPRSPWNIETVLPENTQALPGTDLACSIVSGTIDLYYQDHAGNVNHWESRNSQWIDDKVLIPTSDVQISTPLATVNAGKKHVFYVDRSSPPMIKDLMDGDTMDVASFYPGTRLSALSSNGQVTLFYKLLNPVGAIASRVFDGSTWRDGPIVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6A2</accession>
    <name>A0A5N6U6A2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="4">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_121274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="4"/>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6A2"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="513"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8154167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115112" checksum="A789AB86B1755E0F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6B5</accession>
    <name>A0A5N6U6B5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6B5"/>
    <dbReference type="OrthoDB" id="4924482at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="98" mass="10992" checksum="0E9711FD33163E10" modified="2020-04-22" version="1">MLSGHLLGRTMIGKVPNEVTYAEIRIHLESIPLPRKGVSPEENCVSWTRSAIQKLQEKGLAEQFGIDRFMADSLAFADQRMKSPDSTANIINYTSRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6E6</accession>
    <name>A0A5N6U6E6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6E6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="227" mass="25574" checksum="9B97F9D4A48B99FD" modified="2020-04-22" version="1">MNPRYQQETFASKSRSKQSGAVYCDRHKTYHGKNEHACPNRTKIPKSLSNTGVNGTSLSSASSGARGRSISSGTQDGSITGFQYAVDKGPETDYVDGSWTSESSLSTPMLVEGGRSSFLGTRRNAEIAHNTMYQPARIQRSNDSPVTIVSTREEPVYPPSQKSSTVKQSKRSRGRYFYEKGKHRRDNGRLVHSQEVRSARRDQKDVKRKRLLFPWIMDHLVVLRFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6K0</accession>
    <name>A0A5N6U6K0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_126968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6K0"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="589" mass="66158" checksum="E94B4ABC3AF47032" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7S5</accession>
    <name>A0A5N6U7S5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_147274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="482"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1321"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1598"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1878"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1808"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2114"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2207"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1235"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1808"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2116"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2139"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2163"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2210"/>
            <end position="2260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2318" mass="261132" checksum="279BC7F701B49030" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7T4</accession>
    <name>A0A5N6U7T4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_171522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7T4"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="503" mass="54110" checksum="B7AA9986D7A54493" modified="2020-04-22" version="1">MGSHNATVFVQADVAGQNYTKHGVLVIALATIVAAALPSIAGDLGSADGYAWVSYAYLLAETHLLPLWSNLSVIWGRRNAILLANTLFFAGSLVCALAINMSMLVTGRYIQGAGAAGLVPLVNIILSELFTIKKRAKHMAITNTSWAVAAAIGPLLGGALAEHVTWRWCFYLNLPLNGIIFILLLISLQTDQQNTSLPSSIKAIDWTIVSPIIDGTHMLLLGLQFGATGYPWDSIVVICWIILGISMMTLSIITEWYVPSHRPGLSIELFKHRSPLTAFICSWIHGVISIAPYYLHFFFQTDQDASPALSSIHLLPMVLTAAATTIATGTFTQKTGNIVEPIRTGFLITTLGLSLFTNLDEHSSRTKLTIYQIVFGLGLGANYSAPLLAVQRAIQTGDIAIATTTVAFSHQLGSALSLVISGIILQSRVRRQQPRLLAGLGPDATAQLPSPGMQVPSGAFMRTLTGAQRNLVRVVYASSIRPMYHVYVVLSGVAFLLGFLIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Y2</accession>
    <name>A0A5N6U7Y2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein 25D9-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_147320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7Y2"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28797" checksum="8B26D3EB5F59DFF5" modified="2020-04-22" version="1">MSVKFQDQIQDKIQEKIQETIQDEASKGIRHDTKELAHKVGERFTGGLGKKGYLALYLRHLQKNPLRTKMLTSGVLSAFQEFLASWIANDVTRHGHYFSARVPKMLLYGMFVSAPLGHFLVGILQKVFAGRTSLKAKILQILASNLVVSPIQNVVYLSSLAVIQGARTFHQVRATVRAGFMNVMKVSWITSPIALAFAQKFLPEHAWVPFFNIVGFFIGTYVNTYTKKKRLEALRKRYDQRRGPGSEYDKDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8N0</accession>
    <name>A0A5N6U8N0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_64181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">IBT 18842</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="850" mass="96241" checksum="7BF091C9B1E7FF38" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9K7</accession>
    <name>A0A5N6U9K7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_135454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9K7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="430" mass="48792" checksum="4888244DA6814529" modified="2020-04-22" version="1">MTENHRIEYNWVKGVETLENYQRGGYHPVMIGDVLNGRYHIVDKLGFGGYSTVWLALDTNLKRYVAVKVNIADSLPRETKILKALSSSPVRLGYDLVPVILDEFKVQGPNGKHTCYTVTPAQCNLREISFSRLFSLKVARTLSYGLTQAVAYTHSQGYVHGDIHLGNILVKLPSSFDDLFIKQLYEKYGKPETVPVTRCDGEPLSSNVPAKAVVPLFLGKYAEEFSLSDAHPLLSDFGEAFSPASEVRLGQDCHTPPAFRAPEAKFESQAPLSYPSDIWSLATAIWEIIGMKPIFSTDFVHEDEIVSQHIDVLGPMPLEWWRRWEGRSQFFDEEGCPTESYRENRWFPLQESFEVGVQEWRRKMGDEFDNNEKAAFLDLMRRMLSFRPEERPTAEEVLKSEWMVKGHCLITSGAKVGAAYKHALGCLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9Q9</accession>
    <name>A0A5N6U9Q9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-NAD(P)-binding-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9Q9"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO/CreE_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052189">
        <property type="entry name" value="L-asp_N-monooxygenase_NS-form"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254:SF1">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="634"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8155352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="89197" checksum="8625F11F211B8454" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9S0</accession>
    <name>A0A5N6U9S0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9S0"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025049055" evidence="1">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="226" mass="23523" checksum="03C1C156FAC5DE7B" modified="2020-04-22" version="1">MPSRQQILAAVAAVGIPSVHAAMGSALSTGPVATNSWIREATSTLVLPDGPSGGSSDAITSLWVGMGTSNGDLIQSIADNWQQDDWTMYAYTLTSTGVNSQMPIYGDGQKNADKGAKVTMHYKFDDASGNYTQTVLVNGNTVSTLSTSDGHAQGWGSSVECAENNCGTVGAHSWTDTKIILDSADPNYINTLAKGEGVTGGDMSTSDGGKTWTITTFGIPEHTFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCS5</accession>
    <name>A0A5N6TCS5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742681">
        <property type="protein sequence ID" value="KAE8144188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCS5"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="19755" checksum="BBDA9FA8D4EA99DD" modified="2020-04-22" version="1">MFFARRSAASARQLLRNQPQRRFDSHSAHHHAEPVKEAFGRSFYVTVGTFASAYVLYRLTELNKQADGQSWIGNLIQKYTPSEKVFEERNAIRTLAMEKAAHDRHLFQSQGPRVAFELKQPEVSFNSAPPFNVAAGSSVDLSHVTAHYERQNMEREEARVARMQDGKVVSIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD39</accession>
    <name>A0A5N6TD39_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_108551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742704">
        <property type="protein sequence ID" value="KAE8144176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD39"/>
    <dbReference type="OrthoDB" id="4448397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="263" mass="31032" checksum="249730D29D96D2D1" modified="2020-04-22" version="1">MYNLQELRSRLDLFFRTHTGFRSYAEFLSIPPIFREEVFDQLLTTDTFLVMPDTDVRDGVLGDAILLCQKYITNDSSVTLEALETYYQKNHFQVWNAPYLAELLWYLDDPDSDPDEGFDPRQHVKHLSLAFEWDVLLEYGLDPDDPEKSVVGVLEMLADCPKLKEVTFEIKGSSDGIARLRDIFNRYAAELQTLDERLHRNTDDGDIPAGLMLLEIPFDRQLPRKMIPHPWWDIERKEEMELFEEDWWERQEITEQIPLELVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD63</accession>
    <name>A0A5N6TD63_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_145847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742638">
        <property type="protein sequence ID" value="KAE8144232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD63"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="160" mass="18025" checksum="3B36B2AB403CB03B" modified="2020-04-22" version="1">MSLPPAECIYKRRWVPRPSSITGKSSRPNSETSTTANALPPVLGQSARTTDDDAKLIFGTVFSLRNMVRKLGGEDDSFVTYRTSQYKLHYYETPTNIKFVMLTDTKSPSMRVALQQIYINLYVEYVVKNPLSPVEHPGGVGVNNELFEESLEQFVTRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDP0</accession>
    <name>A0A5N6TDP0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_96782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="ML742542">
        <property type="protein sequence ID" value="KAE8144386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDP0"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000396">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000201">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="778"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="892"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127342" checksum="8AE858F97E2D9E71" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDY7</accession>
    <name>A0A5N6TDY7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_166704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742504">
        <property type="protein sequence ID" value="KAE8144496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDY7"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PNO1 second type I KH" evidence="11">
        <location>
            <begin position="166"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="257" mass="28492" checksum="B4D66553B7872DB5" modified="2020-04-22" version="1">MPAPTALKQISQTAVEAPVAQKATPDQDDEVLIDAGEGDAPTVNPTDESAQQTDMHIDEEGRPIFTPAKDTNAVYRVETRKVPVPPHRFSPLKVAWSRIYPPLVEHLKLQVRMNIKSRAVELRTSKFTTDTGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIRSFEIRDVKASLHGEHLSRAIGRIAGKDGKLKHSIENATRTRIVLADQKIHLLGGYRNILIAQEAVVSLILGSPPGKVYGNLRKVASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE98</accession>
    <name>A0A5N6TE98_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_134476</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742461">
        <property type="protein sequence ID" value="KAE8144662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE98"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="962" mass="107413" checksum="44FF4643478131BD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEQ6</accession>
    <name>A0A5N6TEQ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_134537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742480">
        <property type="protein sequence ID" value="KAE8144591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEQ6"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
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        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="374"/>
        </location>
    </feature>
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            <begin position="46"/>
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        </location>
    </feature>
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    </feature>
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            <begin position="256"/>
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        </location>
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        <location>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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    </evidence>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50033"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144591.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="686" mass="73899" checksum="6D32F284425E78B2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144916.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38498" checksum="B4B535F44765EEDD" modified="2020-04-22" version="1">MFSRTPGDYTGPTSYGQAGPHPSNGMDEYYETIPPQWSGVEASPYIAINHPYSTTAAFPSTAILTPISLPDSSFAHARPSPVLSHHSQEYPYAVPESAPPHGLGITAPFPSDFPRTVTAGLAPMPDPMYDFSGATFSPPQPPVRRIRRSPKPVISSREGPVSILPHPEGLQRLEQERRREQVEPHPHQRPRAPGRGRRDPQAEEEDAFVERLREQNLAWKVIREMFRQKFNKDASEARLQMRMLRRRKDRLARWDENDIQLLIRAREYWENEKYNLIAQKMRELGAKRSYTAHQCETQLRYLDSHREQADTISRIPDYPLTRQRSMKASRGIGVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name evidence="7" type="ORF">BDV25DRAFT_165119</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into mitochondrial matrix"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
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        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="188" mass="21622" checksum="3CA0419447861B41" modified="2020-04-22" version="1">MRSFTSLRGLRAIQTSLPRSTLISRSTSRPFSQLLQRPTRPAVLPQSSLRFAIRHNSDSARPLTDRSEDAAKEAEAEEQNRKRREQEPAYQITFTCKPCGNRSSHRMSKHGYHRGTVVIRCPSCKNRHVISDHLNIFFDQKSTLEDILEQQGGKLKRGYVEGDMEFWDDGTVTKKEESKSDQEQEQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG77</accession>
    <name>A0A5N6TG77_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BDV25DRAFT_164941</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="ML742359">
        <property type="protein sequence ID" value="KAE8145317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG77"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="62"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="512"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAE8145317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="647" mass="71224" checksum="ADE734A6538DA377" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGC5</accession>
    <name>A0A5N6TGC5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron permease FTR1/Fip1/EfeU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_133789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742346">
        <property type="protein sequence ID" value="KAE8145435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGC5"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="39120" checksum="A6647F1053AADD09" modified="2020-04-22" version="1">MTTDVFAVPVFFICFRECVETSIIVSVLLAFIKQTLGSDTDISTRKKLIKQVWWGVASGLFVCLCIGGGMIGAFYGYGKGHFASTEDLWEGIFALIAAVIITEKWRVKLAQALETKTVPGGRMTDRIKQWSQKYFMFILPLITVLREGLEAVVFIGGVSLSFPASAFPLPVFTGLLAGVVVGYIIYRGGNQTSLQIFMVISTCLLYLVAAGLLSRGVWFLENNTWSNLIGGDAGETGAGPGSYDIRQSVWHVNCCSPLVNGGGGWGIFNAILGWQNSATYGSVISYNLYWLVVIVWFGFMRYQEQQGRSLPDSLIRCFKGKDERGIGKAESTARTEVVTDHKLSENGIMRFQEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGF8</accession>
    <name>A0A5N6TGF8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_164633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742343">
        <property type="protein sequence ID" value="KAE8145464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGF8"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="118" mass="13831" checksum="6C9FEF02B898D65B" modified="2020-04-22" version="1">MASQPQINPKRQQELQLQYTNYKNTLQQMAQKIGDIEQEAEEHKLVIETLEPLPQDRKCFRMVNGVLVERTVQDVLPTLKTNSDGLKQVLEELLKQYKSKQTELDNWKKKNNIQVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGR9</accession>
    <name>A0A5N6TGR9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_164351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742332">
        <property type="protein sequence ID" value="KAE8145575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGR9"/>
    <dbReference type="SMR" id="A0A5N6TGR9"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043936">
        <property type="term" value="P:asexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="118" mass="13748" checksum="8C78807255E14793" modified="2020-04-22" version="1">MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGT6</accession>
    <name>A0A5N6TGT6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_164395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742334">
        <property type="protein sequence ID" value="KAE8145553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGT6"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000073">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="217" mass="24221" checksum="F2C8D522343A52D9" modified="2020-04-22" version="1">MSKITVAGVRQNIQQLLEYSQNEKKRNFLETVELQIGLKNYDPQRDKRFSGTIKLPTVPRPNMALCVLGDQHDLDRAKHHGIDAMSADDLKKLNKNKKLIKKLARKYDAFLASEGLIKQIPRLLGPGLSKAGKFPTPISHSEDMNNKVTDVKSTIKFQLKKVLCLGVAVGNVGMTEDELVANVMLAINYLVSLLKKGWQNVGSLVIKASMSPPKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TID5</accession>
    <name>A0A5N6TID5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_163140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742286">
        <property type="protein sequence ID" value="KAE8146105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TID5"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15960" checksum="1B58C10C00324C02" modified="2020-04-22" version="1">MPSPHTATRIHAPLQIATVCLALAGFGVGLSIANDLNELRSYHPIIGYVAIGGVVLVQPFLGIMGRRLYRNTKTPSLYGMSHRWLGRLFTAIGIINGGFGFYYAYPINPDIPAASPIAYGAICAGVGIIYVSVLIWRRRKTKRVGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIE8</accession>
    <name>A0A5N6TIE8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose inhibited division protein A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742306">
        <property type="protein sequence ID" value="KAE8145871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIE8"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000146">
        <property type="entry name" value="Mitochondrial translation optimization protein (Mto1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="592"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="688" mass="75262" checksum="7C4FE76A587A55C0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIM3</accession>
    <name>A0A5N6TIM3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_143932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742280">
        <property type="protein sequence ID" value="KAE8146196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIM3"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52959" checksum="B26EC0E82C4DD8BD" modified="2020-04-22" version="1">MPPQPPPLASILIARFLRSNNYPETLDAFIREANLPRDAGQSKTDEAQTWTIENILEEKKRFDTSVQFERYGDSPEKDIWTDPGKFSLLILVLDSPPSTPKIIQTPTSSNILACSVENWKNSTDANAQPHLVATGADRQLHLLKPDDDNVTSVSGLSESPILSYAQIRNGKYTCLTNMSGQLLLQRDGEVLDTRKDHAKYAVKVVVSEDRDGVWIATAGWDSKIFLYRLREPSDDAATIGAPIAFITLASNPESMLFTRHPETKELILLASRRDSTHLYYYRVEGPSTTPCECELLGRQNLAPHSNAWVAFSPACLALSPHDPSLLAVATSTLPHMKVIIVRLLFPSAESLELRTSGPIETAEPVTQATQAMAALALQNREDAAIVVQANTFAPQTAYSTPQVVWRPDGSGVWVNGEDGVIRGVEAKTGKVVTVLKEGHVIGSKVRAIWAGWVDVSRDGEVSKEEWLVSGGFDKRLIVWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIU5</accession>
    <name>A0A5N6TIU5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_143847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742273">
        <property type="protein sequence ID" value="KAE8146288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIU5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="48686" checksum="47C1FFEB21CE9AAB" modified="2020-04-22" version="1">MKTTCVLYKPIEDVERIEHYRAGGYHPVKIGERFHNRYRMVHKLGHGTYSTVWLAQDEVSNRYVAVKVCTAGSSPRESNVLSRLSEPQRSPDTRRSMIPLLLDMFNTHGPNGDHNCLATTPARMSISEAKSGSWISLFQLEVARAIAAQLVIAVEYIHSQGFVHGDLHCGNILFQLSFEFDHLSTETLYEKYGQPILEPVNRLDGKKLPPEVPQHGVIPVWLGKASEDLTLQEARILLSDFGEAFSPTEEQRYKSHTPLVVRPPEARFEPTKPLTFSSDIWTLGCTIWDIIAQRTLFEGFITNEEDMSCQQIELLGPLPIEWWEKWESYRKCLPENAMPIERPKPFSQSWEDRFETNIQRPRIEEGMPSFEPSERRAFLSMLRWMLSFRPEDRPSAQQVLESEWMVNRALPEYEKIRNKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJA0</accession>
    <name>A0A5N6TJA0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_51474</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742265">
        <property type="protein sequence ID" value="KAE8146397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJA0"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="280"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="167"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="352"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8146397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="462" mass="54406" checksum="8C5BE564947B4559" modified="2020-04-22" version="1">MAFHHRMSQVHSSQQHHGRGRKKEDENDALMRLPDKEIAGCINDIGIPFTSADLIKPNPQQIQMVFEWFAELLMNITREAVDPAMRAAADDIGGDYPDIVPTDTRNLMGFFVSLRRLLMECGVNDFTFTDLTKPTHDRLVKIFSYLINFVRFRESQTAVIDEHFNKSEKTKARIDTLYAENQEMEQRLEEMRRNLRANEAQVKEKVRRNDELKARLLELRRNQERVAETLERVKTDKTRRQAQLEEKTEKVVRTRQEVDKLRPYALESPVTLQASLTELSENLLREKAQIDAMEKRARALQTSSDTFTVVSNDVQACVRLLEDISVELQKEDDEESRASRNKEAISERGNSVREVEQTEKLLQRQLARWHERIETLRKNAQEKADAAQTRMEELREVQKQLREERAEKQRDMERRRIRIEQTEKKMADLKENIESEIQSAHDEYLRLESHIKLYITEMEKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJG5</accession>
    <name>A0A5N6TJG5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NRDE protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742257">
        <property type="protein sequence ID" value="KAE8146514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJG5"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="35953" checksum="E7A9B6EAA8A3F57E" modified="2020-04-22" version="1">MCIAFFSTAHPQYRLIICNNRDEFLHRPTSRAEWWPTPQSHVLSARDLVRAIHPTWMGITKQGRVAVLTNYHEDTCERAVGTYSRGEVVNSWLALPPDSPQTTKEFVTESLSSGKIKNIGGFNLVCGNVMEPLAIMSNRDPDEEPVFWIADKQGQTVGLSNTDYDDRSWPKVPQGEELLVDAIAAHVQNQENEDGLVERLLGVLSTDTLPRLAPTAMAQEYIPILSQSIFIPPVGCDKAQTNKAGVSAREDKEDSPPLPSTPEGQPNHVYLEGLYATQKQTVILVGFDGRVRYFERTLYDNDAQPIPEEARDRSFEFKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKY8</accession>
    <name>A0A5N6TKY8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_161743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKY8"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="126" mass="13621" checksum="5F594EE461D67A51" modified="2020-04-22" version="1">MRPVFDAVCPMADETLTQEILDLLQQCTQNQQVKKGANEATKSVKHGLSELIVLAGNTDPLAILLHIPALCESKNVPYIFVPSRLALGRACGVKRGVIAVSINSSEASELAAQIRSLKDKKERLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL13</accession>
    <name>A0A5N6TL13_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL13"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="156"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="669" mass="74077" checksum="096EFACAF39DAF82" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL41</accession>
    <name>A0A5N6TL41_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_161675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742240">
        <property type="protein sequence ID" value="KAE8146829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL41"/>
    <dbReference type="SMR" id="A0A5N6TL41"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="205" mass="22928" checksum="633F50DAAF392735" modified="2020-04-22" version="1">MSSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTKEVLVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFEALDSWRDEFLIQASPRDPENFPFVVIGNKIDVEESKRMISSKRAMTFCQSKGNIPYFETSAKEAVNVEQAFEVIARSALAQEEAEEFSGEFSDPINIHLDSERDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLB8</accession>
    <name>A0A5N6TLB8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_160979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742223">
        <property type="protein sequence ID" value="KAE8147134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLB8"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="231" mass="25330" checksum="68768C4CBF9E9FEF" modified="2020-04-22" version="1">MASQMKMFAGPQLALFRPTCLSTTFAPSPLSRCFSTTSPALDWLTPKFMEKSKSPKGRPHVATGGSSRGTTVVWGDYGLRMKDHDRRLPASSLKIAEETIKRRLRGMNYTLYKRVSANIGVYTKGNEQRMGKGKGKFDYWTAKVGVSRIVFELKGDLHEKVAREAFRLAGHKLPGLWEFVKKGDPPVVGLTKLGNGVTLESLKRARRSPALGSENTPTPPSSTSSSPSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLJ0</accession>
    <name>A0A5N6TLJ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742219">
        <property type="protein sequence ID" value="KAE8147205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLJ0"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="873" mass="97427" checksum="A88421B71ED4D0E2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM14</accession>
    <name>A0A5N6TM14_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA splicing factor CLF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742209">
        <property type="protein sequence ID" value="KAE8147393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM14"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="73028" checksum="6F2E3BE0EA0B37E9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMF5</accession>
    <name>A0A5N6TMF5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_142652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMF5"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="47351" checksum="CF34F9F35A150B2C" modified="2020-04-22" version="1">MEHLPDNFLFRRLLSLAETRQGARIHDLAYRLDIPYSQLLQDVCYSRRELRQTLPPSLFTKQGIIHDDDVYVCTTMPASYEMTVAFFAILSIGAAMIPLSPDLMPEELADFNSRFNAKCIVLHSGDTELAQTIRKYAQDKGSSVLNLLPVRLCPANNTTNQHPCIGPCITIPSECPVIALFSSGTTGPPKGIIHALNYFTAHAGPFGPEDSLVLCHRPMHYGASLTSAITSILRGIRLGIMRPTATPKQIWGRIRQGGVTNLAGSAGFWVSLMEFFQQQLAELPSKELQSYIDGARGLRVTNCSGVMAMPSTKIFWKEITGRPLHIVWGSTESSIGLKTSSDIDTAYMNSIGRPVPGVTIKLSKGTHGEMRVKTPTMFLRYWDNESATRVAFDDEGFYKTGDLVYLQGNDYIIQGRASTDSSETFSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMP6</accession>
    <name>A0A5N6TMP6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_159888</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMP6"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000670">
        <property type="entry name" value="Serine/threonine protein kinase (Kin28)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="60"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="400" mass="44748" checksum="96C494F94C42C336" modified="2020-04-22" version="1">MAVSPLPTRSPSTTLSTSNTAFRLKGVAARSPGNAPSPQILQNADRELTEQLNDNVRQRYMKDKKLGEGTYAIVYLGHLRTEPSSLVAIKKIKVNAEYKDGLSMDAIREVKYLQELSHPNIIALHDVFSSKDQNLNLVLEYLPLGDLEMLIKDGNIHYGAADVKAWMGMLARGVWFCHENFILHRDIKPNNLLIATDGEVKLADFGLARSFADPYLNMTHQVITRWYRPPELLYGARQYSGAVDIWSMGIVFAELLLRVPFVAGNSDLDQITKICEAFGTPTEENWPGVTKLPTYIPADKGHIVPVQGRDFFLRQFPTAGPVGADLLMSMCTLNPSKRSTACQVLQHRWWFTEPRPTNKEDLPRKAGGSQKMGSDLTRKGGELDDSPFKDTARQLDFNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMY0</accession>
    <name>A0A5N6TMY0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar sorting protein VPS1, dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_159838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742196">
        <property type="protein sequence ID" value="KAE8147665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMY0"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="611"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="698" mass="78893" checksum="C6DE51443C1B3CED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN29</accession>
    <name>A0A5N6TN29_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8147773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN29"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
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    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="259" mass="28291" checksum="523C12A787E94A9C" modified="2020-04-22" version="1">MADAPRGRGGFGSRGDRGGDRGRGRGRRGRRGGSKEQEKEWQPVTKLGRLVKAGKITSMEQIYLHSLPVKEFQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAVVVIGDSEGHIGLGIKTSKEVATAIRAAITIAKLSVLPVRRGYWGTNLGEPHSLPVKQSAKCGSVSVRLIPAPRGTGLVASPAVKRLLQLAGVQDAYTSSSGSTKTLENTLKATFLAVINTYGFLTPNLWKETKLIRSPLEEFGDVLRQGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TND7</accession>
    <name>A0A5N6TND7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_131914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TND7"/>
    <dbReference type="OrthoDB" id="4496684at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="127" mass="14982" checksum="A7569B87223967EB" modified="2020-04-22" version="1">MPWKAQVCPFCGIRYVNKTGLRNHLLRYIGVYRIPADGTHDVLKIEKFLNMDSDSLDIGNTPYKCPSCSEIIMHQRRFIDHVYYRQHYSDSEKQGSLATRRRSRYDPEPHRMWQPTGPFPFLRLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP70</accession>
    <name>A0A5N6TP70_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_158999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742175">
        <property type="protein sequence ID" value="KAE8148105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP70"/>
    <dbReference type="OrthoDB" id="5059029at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025029870" description="Secreted protein CSS2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="185" mass="20492" checksum="1749B057146CBB75" modified="2020-04-22" version="1">MLFTRNALITVLCTLPLSWASAPVSDKPSAESQENEAIFDNSYSAYISQIPMAKFQDTLSIMTSSYYTATEYILNMTNTLSTSIKDWSNTVPVLTDCKSLSGTHENLKWVYYAIEPHCGIEERTSIVKHAIDHYQKSPEQSFESCSTQCLRFDEGGKLDGWIKVGLSDGFNQAARCDSVGCVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPC1</accession>
    <name>A0A5N6TPC1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_158864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742172">
        <property type="protein sequence ID" value="KAE8148155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPC1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="565" mass="61124" checksum="A5544EBF001D8D20" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPU4</accession>
    <name>A0A5N6TPU4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_158408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPU4"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="170"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="782" mass="88935" checksum="A9EC6E9D84B00B8E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ06</accession>
    <name>A0A5N6TQ06_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_158783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742170">
        <property type="protein sequence ID" value="KAE8148201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ06"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="686" mass="76441" checksum="5344DDC8E8F41A61" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ39</accession>
    <name>A0A5N6TQ39_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_168397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742159">
        <property type="protein sequence ID" value="KAE8148472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ39"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="35905" checksum="09C8D5E4BAF4A5EE" modified="2020-04-22" version="1">MAAETASSVVTVHALNAGHLTLPERFFVTPLINPEERQTVPSLSFLIQHRAPSGTLTRLIFDLGIRRRPQQYNAKIRKHIESRYPLSGNPDVVASLAQGNLTPSDIDCVIFSHVHWDHVGMPCDFPQAQFIVGHGSMALLDGSDALNNGSHNHFESDLLPLNRTLELRPPDEGIGTHQKALIPGIRCISNSSWKPFGPLPHTIDVFSDESVLLVDAPGHLPGHINLLCRVSLEPTRYVYLGGDACHDRRILTGEKDIAQWSDPDFPGRICCIHTGRGKSRETIKRIRNLEQESLGFGKVEVVLAHDVHWADKATRDGRFFPGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQA5</accession>
    <name>A0A5N6TQA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Asx homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_17220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742159">
        <property type="protein sequence ID" value="KAE8148480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQA5"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="435" mass="48832" checksum="ED7F2F88102CCF3B" modified="2020-04-22" version="1">MSSSKAKTPKRNPRRNAKDRWEEQKLMTSSNSPLVGLDLVKLLADPRAWTCLEESEKKEILNLLPEDLYSHTTPPSDDPDAKIPPLPESFLRYSNHWRDGIRQFQLDLEQGRYDPVWLREAEEAMQQRAEGKFDKFKEEEFEQFWGQKQKMDKTLAAGQSRQVKLSTLIEQGVVRGGDIWKYSRAFSKGANRVLVEKEVRILDAKDGSLTVAFPPGQKVFLSTCQSSKSKDSVAEDKSDPEQPQPDATTAVKTELDKSTEASVDVHSDAIQVPETSPRTKRKPKTEAGPRKRQRGNSSTALTQEATTEGVQAETQPEDASTTQPVLEHGTTELPISDIAQSAPMENNNQAPADATQQVPDVAENKPEEEDVDEIIISGITQPNAIGNKILETDGRVREVPHGNAWKEFRAYRDNQDMGSLWEVRQAWFVKAQKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR04</accession>
    <name>A0A5N6TR04_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_130953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR04"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="517" mass="56507" checksum="39B8F77765C0E739" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSD0</accession>
    <name>A0A5N6TSD0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_156768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSD0"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="455" mass="52971" checksum="72EEFFF86BE0D4D8" modified="2020-04-22" version="1">MSLSRSPSPHPGGGWSSPGLTPGSGTSTPHSGLLSPNPLGSSGISWAAAKAKSDEVRGYPSFSTRNNGFFSRSKRQLSATLPTFRVTSRSPNGYIDKDEFGRQPFSPGKSWRPFGFGKTMLRRRRLRLFLVLAVVLVGYIFFWSSLMERYRRSSFGGGHKFVIILESNIEGGVMELKGAREWAVERNSVKNKQMYASEWGYELEIVNMLAKKRYSHEWRESWEKVDIIRETMRKHPNAEWFWWVDLNTWIMEYSYSLQDHIFNRLDEIAYRDINVYNPLNITHPPTGPYLDEVSRSAEGDGDPSSINFILSQDCSGFSLGSFLMRRSVWTDRLLDVWWDPVMYEQKHMEWEHKEQDALEYLYTNEPWIRSHVAFLPQRYINSYPPGACGDGNDPNIHYAESGKDFMVNLAGCNYGRDCWSELWEYRELSNVINRTWRDTMREKLEDLYDRFWKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTA4</accession>
    <name>A0A5N6TTA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEMO1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTA4"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="366" mass="39988" checksum="D71A1102C246EAE8" modified="2020-04-22" version="1">MQSREASHAGSWYSDNQRTLTRQLDQWLAQVPNDIEGIGPLPVSGARVIIAPHAGYAYSGPCAAYAYKSLDLSKAKRIFVLGPSHHHYLSTLALPELTSYYTPLSDEPLPLDTELIAKLRSSKAVKSNGSTVGFTTMSRSIDEDEHSIELHLPYIHRLLQLQYPNRSTSQYPPLVPIMVGSTSASTESAFGALLAPYLEDPANAFIISSDFCHWGSRFRYTYYVPQAPKPGPKLPLSANSLPQPGDEISNVEEKIELVSAGQSLQRRDRISSREPAIHESISAFDIATMAAITTGETANFLDTVQTTGNTVCGRHPIGVIMAAIERIAGQVEGKKGKFHFVRYERSSDAVTVDDSSVSYVSAFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTB5</accession>
    <name>A0A5N6TTB5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_156469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTB5"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="310"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="718" mass="76062" checksum="90650A50535058D3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTG9</accession>
    <name>A0A5N6TTG9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_155880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742116">
        <property type="protein sequence ID" value="KAE8149658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTG9"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
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</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
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            <strain evidence="2 3">IBT 18842</strain>
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</entry>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <strain evidence="7 8">IBT 18842</strain>
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        <source>
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            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_140314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV20"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="33124" checksum="518D4E03D61C15DB" modified="2020-04-22" version="1">MDSTHGSGLDQATEDLISRLYLQDALQIEDAVDYFESGKGKSRELTDEELAFQLQNGELKDESRRYSDNRMAMSLATAVHTDGQILTDILLDEERAASGRAIKTPQAEFSAAAALRKQKPVGLRSCVACDDCMKPDNTLHAPCGHEYCRSCIEGLYNASLTDETLFPPRCCGQHIDIRIARTFLKSDLLERYEKKRIELETPNKTYCHFLKCSAFINTSCLKGQVATCPECNRKTCTSCKSQAHTGDCLDDPATQQLFATAKVNGWQRCYSCQRLVELDHGCNHMVLVRLICPLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVD0</accession>
    <name>A0A5N6TVD0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVD0"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="53771" checksum="024668F8F213B83B" modified="2020-04-22" version="1">MTDSIKESASHCESLAEESGLPEMQYQKENIIDPNHPQNWSTGAKFSTYLTVCFFTFLANVNGSNFTVATQAVIKEFNASQTQAGELVCFNVFLLGLGNVLWVPLMRVIGKRPVYLLSMISLSMMNVWSSQASSYGELLASRILSGFASAAADATVPAVVSDMVAPQDRGHYLMFFHLALTAGLFIGPLINAYLVQEQNWRWMCYFEAIAAGAIFIIAIFTVRETTYLSRNAFAPKRTPRQWMSLRLGYNPDASFLRTVSDIVCNVAYPQLLWAAFAIGISVGWNIVVQLTASRTFTAPPYNWPAGSVGLLSLSGFIGSVLAFWLGGRLIDIISTRYTERKGGVRLPEYRLPAIVIPGVVGPCGILIFGLCIAYQTHWIGAAFGYAMQAFGVAAISNVAVTYSLDCYRPVTGEALVIIFTVRNTIGMLLSLYAADWIDRQGPAPVFGEMMAIQAFSILLALPLFLWGKRLRSVTATYGPMKRFQDQVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVY0</accession>
    <name>A0A5N6TVY0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein efr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_114109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVY0"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1140" mass="122697" checksum="EFFE441EEB3FE68E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW50</accession>
    <name>A0A5N6TW50_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP synthase subunit C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_154137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW50"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="200" mass="20606" checksum="E6E7D1ACA69E5883" modified="2020-04-22" version="1">MGLYYPTGVVTVSLLVIGGYMLFHGDGEQFNVGQFLESVSPYAWANIGIAMCIGLSVVGAAWGIFLTGSSIVGGGVRAPRIRTKNLISIIFCEVVAIYGVIMAIVFSSKLNLVDDDAIFSGSNQYTGYALFWGGITVGMCNLICGISVGINGSGAALADAADGSLFVKILVIEIFSSVLGLFGLIVGLLIAGKAADFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWE1</accession>
    <name>A0A5N6TWE1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_112400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWE1"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="498" mass="55236" checksum="72AB64161303771F" modified="2020-04-22" version="1">MASISRSSLRLRSVMRVPGARTISTTPHLRAAAKPFFADEPTAPKLSTAIPGPKNKAAAAELDKVFDVRSINMLTDYSKSVGNYIADLDGNVLLDVYAQIASIPVGYNNPHLKQVAQSPEMITSLINRPALGNFPSADWAEILKTGILKVAPKGLDQVFTAMAGSDANETAYKAAFMYYRQRERGGPEKEFSDAELESTMQNQSPGSPQLSILSFKSAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQATFPSLKYPLEEHAQENAQEEQRCLQEVERLIKEYHNPVAAVVVEPIQSEGGDNHASPAFFRGLREITKRNNVIFIVDEVQTGVGATGKFWAHDHWNLESPPDIVTFSKKAQTAGYYYGNPALRPNKPYRQFNTWMGDPSRALIFRGIIEEIERLGLVEHTAQTGAYLYSGLERLAQKYPEHFQNLRGKGQGTFIAWDTPKRDEFVAKAKGAGVNIGGSGQSAVRLRPMLVFQQHHADILLESIEKIIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWR0</accession>
    <name>A0A5N6TWR0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWR0"/>
    <dbReference type="OrthoDB" id="4346081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="246" mass="27100" checksum="1399A20885F3368A" modified="2020-04-22" version="1">MPNQAEKAQADQKTQAIAQIANVSRLLRDAISAAIPVAPEQYLTVSIPGTAIDTRDISEGGTFAWDAQDGAFAPTQVMQAEGKLVDNMIPLSYVMVGNTGKSVARSYSRALDCLVARKASVSTGKHPNGENDMRSPGDKSYDDAMKFLTTPLPNGFTPVDLYVEKQDAWRKAQDEWDTAILEAKTKAQFPNSPVHQVQAYNDWNQAHYRKYKTAVQGRYIDWVTNGHKFNVEQNFGIVGTYELPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX46</accession>
    <name>A0A5N6TX46_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX46"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="81" mass="9004" checksum="07BD5F730E1493D8" modified="2020-04-22" version="1">MSSRFNRQGFSNRVRAKDDDPFVEGAGQHAQAGTDQDVHASSQASDIDVTTGMLDQKSRSTKYHFTHDQLNHADEISRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX55</accession>
    <name>A0A5N6TX55_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_153471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX55"/>
    <dbReference type="OrthoDB" id="2730545at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="27236" checksum="EBE6C21C6F562B73" modified="2020-04-22" version="1">MASREETRYRPCRVLDDNQIPYVVWFEDALHHYGVPTVVFDLYILVPSIEIAADCLVKAGWALQSGHTIGMAEVQIPQQRLVLPGETEMQTVLLSVSDWKFSLDDSRRRVSLSKGVDVVIPPLPSLLDALIETWLDGPSDDPTLLLHLACQVNYLYDYVPVLKERSFADQMRYEHRQLHYDVLAGMDASTLPFRNHERGVREALLQGRYELQECSASREDKLLSGDWGSVRLPEPEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXC1</accession>
    <name>A0A5N6TXC1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_153404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXC1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000453">
        <property type="entry name" value="MFS allantoate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="56368" checksum="312FD9E336FD8378" modified="2020-04-22" version="1">MEDDSKNSKVDTQSATSVEKPDIDSGEVRDIGADLYAEVGQISPEELEREGAEVLRLLDWRLMPLLYVTYVIQFLDKLSLNYASAYSLIPDLGLEGQKYSWVAAIFNFGYLFWAVPSSLLIQRMPLAKYMGVMLLVWAALVIAHIGARNYAGILVLRFLLGMAEAGVSPCMMNFTSMFYKRSEQPLRMSVWLSGNGMATMVGALLGFGLGHSHNTSLHSWQLIFLTIGLLNFVMGCFFLWLMPDSPSTAKFLSHRQRVVAVHRVSENMIGVKTKQIKPRQALEILYDIKVLCCIGIGISCGVINGGVSNFSSSLIKGYGFNGIYATLLQLPTGAIEAVIVPICGLVSTYVRDSRCIVLAVVCLIPFGGLLGIRFTDLNHRWTLVGCTWLQYIIGAPVIISWNLLSTNVAGHTKRSIANGLWFSVYAGGNVAGANIFFAREAPRYYSALTGLLVCYAGMIVLSAVAYVAMWLGNKRRDHRTPLETTEQALAAVLDGFKDLTDMESKHFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXS4</accession>
    <name>A0A5N6TXS4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_153235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXS4"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024908914" evidence="9">
        <location>
            <begin position="17"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="180"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="493" mass="52319" checksum="09A3EBBE9C5825AB" modified="2020-04-22" version="1">MKGIFGLSLLPLLTVASPVAVESIHNGVAPILSASNAKEVPDSYIVVFKKHVTTHAAAAHHSWVQDIHDSATGRTELKKRSLFGFGEDLYLGLKDTFDIAGSLVGYSGHFHEDVIEQVRRHPDVDYIEKDSEVHTMEESVEKNAPWGLARISHRDSLSFGTFNKYLYASEGGEGVDAYTIDTGINIEHADFEGRAHWGKTVPTNDEDADGNGHGTHCSGTIGGKKYGVSKKANLYAVKVLRSSGSGTMSDVVQGVEWAVESHIKKAKDAKDGKVKGFKGSVANMSLGGGKSKALEDAVNAGVEAGVHFAVAAGNDNADACNYSPAAAENAVTVGASTLQDERAYFSNYGKCTDIFAPGLNILSTWIGSKHAVNTISGTSMASPHIAGLLAYFVSLQPEKDSAFAVDELTPAKLKKDIISIATQDVLTDIPSDTPNLLAWNGGGTSNYTEIVASGGYKAGNIKDRFDGLVNKAEKLLTEELGAIYSEIQDAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXV3</accession>
    <name>A0A5N6TXV3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_153658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXV3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="110" mass="12737" checksum="69413D1D9114589C" modified="2020-04-22" version="1">MIYPLVSHPLFFPLVTLPVTGDCFSFSFSSLLLFTEIFRWSETNTCRFSISRVSSMGPLVLFPLWFNESLFRLERIHTQVESICLPRGPSTMVSRARSQLFKIRKGLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY11</accession>
    <name>A0A5N6TY11_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MmgE/PrpD family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_128947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY11"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="352"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="557" mass="61435" checksum="43B7B87AE9B8BBFC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYB6</accession>
    <name>A0A5N6TYB6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_128803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYB6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000063">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="298"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="455" mass="49055" checksum="CBE092D8D0B79790" modified="2020-04-22" version="1">MPKTLANLRRKDLLQTKGLIDGKWTNASSTDTFDILDPASLDTLATLPEMNAQDTHQAIEAAHKTFASFRKTSARQRARWLHRWNDLVLENIDDLALILSLENGKPLPEARGEVIYGASFLEWFAAEAGRTHGETVPAANQSQRILTIKQPVGVAAMLTPWNFPIAMITRKAGAALAAGCTTVWKPAGETPLSGLALAVLAQEAGFPEGAINVVLALNKVAEVGQGICENPLLLAQQCSPTLKKLSLELGGNSPFIVFDDAQIDHAVDALVMAKFRNSGQTCVTANRIFVQKGIYDRIGPLTHERAVDKAMEHIEDAKRQGAQVMLGGAPCSELKGYFIQPTLIHDMKPGMITTREEVFAPVLGMFPFETEEEAIALANNSDVGLGSFIMTENMSRCFRVAEALEVGMVGVNVGMLSACESPFGGVKESGYGREGGTQGIEDYLAVKSILLGVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYM4</accession>
    <name>A0A5N6TYM4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_153148</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYM4"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Coatomer subunit zeta"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8151161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="201" mass="22027" checksum="A0DEC5478D3B1463" modified="2020-04-22" version="1">MPGSLSLFSVNAVLLMSADDGSRIFAKYYSPPHPPAGAAPNSTDYPGANPYPTLKEQKAFEQGLLEKTNKQTSDVILYDNRIVVFKMESDVMLYVVGSADENEVLLYNVVLSLRDALGILFKGATDKRTIVENYDLVALAIDEIIDDGIILETDPVLIASRVSRTPAPDAPNLKSIDLSEQGLLNAWELGKRRLAEGLRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ14</accession>
    <name>A0A5N6TZ14_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_138712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="718" mass="81110" checksum="DEE1F10834730EAA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U024</accession>
    <name>A0A5N6U024_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U024"/>
    <dbReference type="OrthoDB" id="4301468at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024864748" evidence="1">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="191" mass="20976" checksum="8F57A5A1BE2F3703" modified="2020-04-22" version="1">MKFSLSSTVVAAATLCSVANAAAFPSIPETCLEIPQVLGQKPMKLMQYFHTQVCEKANCTATINQHNQYLHNNVYPHLIQDINTKLGVSSSEQALFNQTNTQVVAAVQKSCASEGNKPLCNDVQGLFQYGACAFKASQPILEQHMKQISGSVKLTEEKCQKIKQLDSDQTAWSKTLPGYVDQFAAQCEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U071</accession>
    <name>A0A5N6U071_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U071"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="52083" checksum="3FBE925619B39482" modified="2020-04-22" version="1">MGQSWTEFFFRGYPSTLVDLFRESPRNPDDLRRFTSEGFWRLGKPLRTNMPRGHHIMVLWFILQMEDGSSVRYVAKTFSNFSIHEAESIIRRSGLNPAKFSASEVQRQCDPFLIEARAFEHIQRFCPTPQRAYFPRYLGVITDITRNQFPSSCVLRPRAVVLEAIFPNISSRRILTETKDHINPLLNEFKERLNELSISQLELDWYVSLFTNRLRQIMALHNIGITHGDVRDDHFRLPEDFYDTVLYDFSASYTFSPSMPCRRRLRSLSVLTDTEERQLQEIMFDRAVKLDLRHHLANFLDLDLSTVESLLFQPPGVGGGDLELIILKTSSQPDGFTMPSLASVFPFLESISPKEDPTWHVTRAQSLPHYSCAWLLGTETSGVSGTMLLSFDGRSLVEFDTLPIHEGPYFVVLFPLSWDRHEVHESLINVCNEFRSTGHAGSILSKSKALGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0B6</accession>
    <name>A0A5N6U0B6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_151790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0B6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000822">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="76"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8152025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="396" mass="45067" checksum="7CAA7265E710A48A" modified="2020-04-22" version="1">MATGTVDPSAPKDVQGSSASPREADTSPSNVHGKEKQMVAAVRPPQQRHLNPFVITERPEEKQLGVSTRTLTVNDFALLKTLGTGTFARVWLARLKDEIQQRNKVYALKILRKADVIKLKQVEHVRNERKTLSAVAGHPFITTLIASFSDDQSLYMLLDYCPGGEIFSYLRRARRFNENTARFYAAEITLTIEFLHDVEGIVYRDLKPENILLDADGHIRLVDFGFAKQVHDRETYTLCGTPEYLAPEVIHNSGHGLAVDWWALGILIYEFLVGQPPFWDQNPMRIYEQIVEGRIRFPQNVSPAAQNIISLLCKTSPTERLGYISGGSARVKSHPFFSDIQWDDLFYRRVKGPIIPRVDHPADTGNFEEYPDPDVRSQNIYTDDLRKKYEALFSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0B8</accession>
    <name>A0A5N6U0B8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0B8"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="400" mass="44735" checksum="B8E78CA01115B63F" modified="2020-04-22" version="1">MPIRRPHRKSRHGCKSCKRRRVKCDESRPVCSHCQQRQEVCDYTAEVPYIWATEGKSSGQRGRSRDKSPSQSDSGVSPTTGASFDILDRFGAGTVFTATPSLDMNQLRLIVQWQKETHRLFARNEETRHVWQVLIVDEALNVPFLMHGVLAVAALHLALCGVEPQRASWLALATSHKGQALNPFLERLNDVRPENAKAMLGFAGLVVAFAFGSALTGVADADQPSLDTLNNIFVLCRGVQQITNSAFSHLRQSSFAPLFAAVPPPTILPDAVKNSLDHLDMLNATCGLEGDHDVPTYEQVIRALRDLSAYTYAQPTSMTMAAGWAIRTTPSYLEYIQRKEPLALVVHAHYCAFLHLARGNWFLQSWGSCVLRDIYQLLSSEWRTHIQWPVHEVFGDDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0E6</accession>
    <name>A0A5N6U0E6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_151712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0E6"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_2G17475)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024854414" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="441"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="754" mass="83488" checksum="C3CF8EBF40A66409" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0M3</accession>
    <name>A0A5N6U0M3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_128402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0M3"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="280" mass="31228" checksum="6E66FB613AB1546E" modified="2020-04-22" version="1">MKLLRISEFLLIFSTIFLKISISLYLKRLFLKSKKWKIFFWCFIAFNTITSALDAAVIFPQCTPVEYNWNKSVEGRCWSSTAIDAIGIAQGVIAASTDFVLSILPIIFLWNIKLPKRVKVGICGIMALGFASGAFAIARTTLVPSLTRTEDPTWDLVDLFMWAVLEATFGVVAAAAPSVRPLLGHNSMTTNYSRSKSHSLPLRNHRISRADWDTTVLDPQNDTTWHGEDEDSESQLRLDDRGIMKTTSIEVVTTQGPTFISETDGGSTSEGSSDRKYIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U144</accession>
    <name>A0A5N6U144_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_151842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U144"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="183" mass="20456" checksum="0884423D807C19A8" modified="2020-04-22" version="1">MVRYAAQEISAAKSARARGSYLRVSFKNTRETAQAINGMKLQRALTFLDNVTNKLEAVPMRRFAGSTGRCAQGKQWGVSKARWPEKSAKFLLDLLKNAEANADTKGLDTGNLVVKHIQVNQAPKGRRRTYRAHGRINPYMTNPCHIELILTEAEETVQKAVAKRDAHLSSRQRGAQIRRALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1F5</accession>
    <name>A0A5N6U1F5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_151542</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1F5"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8152209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="109" mass="12276" checksum="27748807DDA7D847" modified="2020-04-22" version="1">MSMTPGPKSRSSTPTVFEQQREELVKEIAVGMEQVLQNINRLNRNLESIISVGNEFSSVEALWSQFENFMGRPEEKGGSDSREKEEHAAEGQSELSEEHDMDARSEMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2B6</accession>
    <name>A0A5N6U2B6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Basic leucine zipper (bZIP) transcription factor atfB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_150540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2B6"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="379"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="475" mass="50526" checksum="145B1D98162364B4" modified="2020-04-22" version="1">MDAKKNALEPEDHQAPSSETKNQKSDVDPQTSLAPPPRPTITSATDTPDYFSSVHNPFSLEPNPFEQSFSGGTGGGSSGETPGKSILPPVAALTSPALPGASSAGGGYSWSNSLRSGPLSPAMLPGPTGSSDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLQQLQSGGATPSTIEFHRTALNAAKKNALNAPTSNPTSDPEPAHQNTSMDLKGSQPAAVDPFGHHDAADAANGLFMLAKGGQTNSNQFSVPNQSSIPPQNIQNTDQSRDSDRRSSQNINGANGGRETSGELSDMQSEQMKPTKGKRKGAITKPGVTNNRRKADDTPAKGSNKKVKVSPEPPSDPGDSEDDDEQRKKSQGDSKKMTDEEKRKNFLERNRVAALKCRQRKKQWLANLQAKVELFTSENDALTATVTQLREEIVNLKTLLLAHKDCPVSQAQGLGPLMMNGMPADYEQYRHNVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2C0</accession>
    <name>A0A5N6U2C0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_57829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2C0"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025014691" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="288" mass="29162" checksum="4E1ADBECB9B3C413" modified="2020-04-22" version="1">MRVSSLSFVIYTLSLLAVVSGQSVAATGGSDNAVTTKDTAAPTQTEAPTTSSTSESSTSSTSSETKETTSKTTEAKPTTTEPTTTSVDPTTSTTDAPAKTTANQPAQTTAAKTTSTNNNNNNNNNNNNNNSSSNDDKTTAESTPSTTATPVVKTLTTIQTISGSAVQTTMTTTSTPVGAATDGPSLNNEDKDSKNSGLSSNQKKTIIGVVVGVGGAILIGALAVVGWRIHARKRAAHDNDEATDLMSGTAVGSGVREKAPSPAAGGTPFKSTLDQYHNPGPVNAASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2E9</accession>
    <name>A0A5N6U2E9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_137481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2E9"/>
    <dbReference type="OrthoDB" id="4226308at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="11696" checksum="C31450510801E750" modified="2020-04-22" version="1">MAPPTSRRLLIFQEARNPQNTAEVVYLPVNKLGLPICGPGPELPSILELPLRILRVFTDIFNQPKYKGWAIVSAGPYHDTSEEGKYYAVVLEQTQGQSQDSSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2G1</accession>
    <name>A0A5N6U2G1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_127719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
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    </dbReference>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="371"/>
            <end position="801"/>
        </location>
    </feature>
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        <location>
            <begin position="1287"/>
            <end position="1595"/>
        </location>
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        <location>
            <begin position="1643"/>
            <end position="1720"/>
        </location>
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        <location>
            <begin position="1762"/>
            <end position="1836"/>
        </location>
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            <begin position="1287"/>
            <end position="1421"/>
        </location>
    </feature>
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            <begin position="1449"/>
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        </location>
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            <begin position="1604"/>
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        </location>
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        </location>
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        <location>
            <begin position="1619"/>
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        </location>
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            <position position="1319"/>
        </location>
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            <position position="1509"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2131" mass="232212" checksum="1B8277572D3998EA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2N7</accession>
    <name>A0A5N6U2N7_ASPAV</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_170022</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="37200" checksum="D3B5F888447644B2" modified="2020-04-22" version="1">MAPSREILESSRPDPDFEQAAISQSSPPFPTNASLQTLRSITEGPKREAREALGGPPPTLTEQDISIPVRNGRSVLAYVCVPSDDIDTAPLPILLFFHGGGFCIGSRHDDLLSNRAIATRGGIIIVSLEYSLAPERPFPCAIHDGFDALQWISNNPSRIHPRASPSAGLIIAGTSAGGTIANAVVYLNRDLGSSVKVTGQLLSASPLLPQSMVPARYRDDSVSHAHNAKAAIPAAEVAQLFLEAYKPDHSSPLCVPAIHPSGHAGIPPTYFQACGLDVLRDEAIIYERILRDENRIPTRLDLYPGLPHHFWEFFPQLTTQIEKRTDDTVKGIHWLLNLNHGSS</sequence>
</entry>
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    <name>A0A5N6U2W3_ASPAV</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_137386</name>
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    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="147" mass="16125" checksum="573E50F270170DD2" modified="2020-04-22" version="1">MGPQHLRVLEAYFDGTNLIIRQTKLLEMKNYDADTVDILARWWFGYAIGETKAMPEGSPICNAGVGLGPWEWFASQGLIGHLKHDDTMTLVVLITPGDDYGLIPIICIIDAERLLFDSMITVLAKGSTASSNKDINLQPESTTGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3T3</accession>
    <name>A0A5N6U3T3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
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            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153089.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="179" mass="20722" checksum="42A23F8D1F4FBB5D" modified="2020-04-22" version="1">MPLYEIEHGLPLDQIQRDELAQAITHTHSRKFATPSLFVNVKFTDTSNQHNYIAGKEAEFHLDQRKINRITAYVRAGGTRTREDFDDLALRISEAWNQTVNGNQKVTKERELNRVFIMGAITAGYENGFLLPRRLIEPDMTIQAGDDAKWLELNAPKFEELARQGDQDFKEMVEEMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U424</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_136987</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U424"/>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024998574" evidence="2">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="159"/>
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        </location>
    </feature>
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            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
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            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="232" mass="25604" checksum="C48D8A27FAF08493" modified="2020-04-22" version="1">MYRFIILLTLYISLVAAGKSASKIAEPKTPKPLRDNCKDISVYEWRPNANQGPIPMLKASCKQPNGNLKESTVDLDNCLGFDRFKGTIIRNVQEALSLGKWCRPCLYNKEWVGSELRCSCDTKSKQEYPMIAKFDLEAVLGFDKGKLYCLHRGPNSNNGVLKKQNTDFDSKGGKDQGSKSSKNVNFGEVTYEPDGNTQGNNQESGQGNTQTNSKANGQANNKGSNQANNQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U463_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U463"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="560"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="15"/>
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        </location>
    </feature>
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            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
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        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="920" mass="98976" checksum="E57255B36C4D31BC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4X5</accession>
    <name>A0A5N6U4X5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136743</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="361" mass="39017" checksum="A151411D727271E7" modified="2020-04-22" version="1">MDPLSVTAGVIGIAATTLHSISRVESAISNIKHAPEAISSVRSELQSVCTIVATLQRTCQDPALINDDLKSILQGVPINATLQNCAKICDEFHTALTKWTKHSTEERLHWLDRLRTGYVEKSTIREFIAEVGSCKVTISLVLDTAIFLNACRASPHTTTGFDDMENKLKAVQNDAESLICRHHSAPGAHVPGTDGGQQQHGFAGDTSTSQTTGQGVQFQNQKDTAEYPRRTVEKSNLQQIYDNIRTAGDATIGKFDVSDDTCVNQQFTNITTERGGRAVIGVGRIGPGRNVGPHDPSVNKRVVGQSGAHVSTATSEELGMLSQHPCCHLVLLVALPLATRIPRLDVDSDIKLMRDVILVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U508</accession>
    <name>A0A5N6U508_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_136664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="7"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2512"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1042"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2604" mass="282546" checksum="789FE925B462C770" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U575</accession>
    <name>A0A5N6U575_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U575"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="63" mass="6695" checksum="05BC7EE09EA30BCA" modified="2020-04-22" version="1">MSLMSLLHTRLVALQVSVVLVVALLSGCAPSLGCTMTSRRGALRAPAASQFRRLGLGARIFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5K1</accession>
    <name>A0A5N6U5K1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_14905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5K1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="270" mass="30492" checksum="D493E90C5BC08358" modified="2020-04-22" version="1">MTVTDIATIDLGKLTAKDPFELERLIQAAQSPGFFYLDFQNDNATKVVKEQGPELFTVTDRYFDLPAEVKMKDFRTDQPASSDRGYKSCESDETFEMSYDEMQQGKLRLPTPLSEKESVFNEFHSHCHLAAKTLLTRLAEALSLPLQEYHREGEPTETGLKLIAEPSLDKASDVQENKHTDSGTFTMLFYNEWSLHIQLPGGGNWTFVPPPSPGVALVHVANSLQRMTQSQLHSPLHRVTQPADGAAKRYFLSYFLRPEADWASREIAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5U9</accession>
    <name>A0A5N6U5U9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_126845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5U9"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="454" mass="50953" checksum="781421113C92A251" modified="2020-04-22" version="1">MLEHDLELTPDRQFVRWGRENKLHPRNWPFLRKCYDTGLVCFLDLIVFLLGQVVGTIVFPPWSEAFGRKRLYVLSSGLSSVCCVVVGVTDSIAAVVIGRVLGGFLAAIPYTVGSGSIEDMWNSRERIWVFFFWTIASNIGLCVGPIIGTFVTASLSWRWVFYIYAMIIGAATVLFFFMRESRPALLLAREVEKMCRETGEKLEALNHDHMPEFRSFVRMALFRPAALFVKEPLVLVIALMIAFAFGLLYIFTEALQPIYESMGFSTTHSSLAFVAIATGIWFSSLTRILDFWILDNLHRKGQPVKPEHKLAGLAIGAPVLAISMWWFGWTIPPHVQGVHWIVPTIPLAMMGYSLNEFDTVLYGYLGDSYLSYSASATAAVAFLRALLSGVFPLFTNIMFRDLTPNVAMSVLAALATVFCAAPLLFIRYGERIRARSKFAKHSLQIQAEIGNKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5W2</accession>
    <name>A0A5N6U5W2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_148522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5W2"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="246" mass="26508" checksum="7B9A7EEA9B2540B3" modified="2020-04-22" version="1">MASQSAFKSAITNRSLRTVRLELEFLADASVITPQQLSSILSQLPTENERSIAVPQPQPQPPVQQQPPIVAPSQPSPAPYSPPTQQFANTSLNEKSGYHQPPPQHYPTPPPPAYAQAPPVLSVASALYAYTPTDPGDLALQPNDRIQVLEHMNADWWRGRNERTNMEGIFPRSYVNVIDTKSAAAPPSSYGNMPLEVSQSGSAANPEEAKNGKFEEHGKKFGKKLGNAAIFGAGATVGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6F7</accession>
    <name>A0A5N6U6F7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_136158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6F7"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="373" mass="40917" checksum="F6B066D0D8718E7E" modified="2020-04-22" version="1">MSSSSDTSALLGGAESATPQYAGMSIVPPSPKGVTIIAVDVLLIVLTTAFTTLRFYSRQLRKGTLFPEDYLYLVALVFFHGLCWVSIAINVKGFAHHIWDLDPQQTTTVLKVGVTLYTDFMPKLTTRRNHQMTFASSVLYAVSLGLVKISICWSVARIFSTPRTVLGAYVLMAITALWVVANITISFVVCRPVGMNWGDLTPDGHCGNLMVSYTILSIFDLVVDLFILILPIPTLWSLGMPTATRVGLILVFSFGVLTMVFGAIRPAALLRVQEPDVLYTGAMGHLWTVVENGVALIVCSSALLRPVFDRATSTLPSLTKKPSTKSTAQPDENTLVGDIWIGIHVRERRYDYTMELEQGRSATQKYWSGLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6U9</accession>
    <name>A0A5N6U6U9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SGF29 tudor-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_148528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6U9"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000055">
        <property type="entry name" value="SAGA complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="195"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="36059" checksum="7408E2B6C1829F00" modified="2020-04-22" version="1">MSRNRPRGPPMPRDNGLAANEETDMWNKILQDLRKAKEKNDKQKSLAEQIAALNEKIGKEGGKPSLQEHNQLDALYRQMLKLCEDERAILQDEPSDVIKNLGLLTALRQASEAEAPLNRAAALGKSRKKRNDVDGSAADSPGPSGASLSDKTGRMKGGIQRGTSVSSNQARDSRDNVQVKVEEGTEGTKGTIAERSGHLVVGAEVVFKHNKNKQGVEGEGIQCIIKGISGDGHKKRYDVQDPEPNENGEQGAVYKTTAASLIPIPHIGSTLPSFTLGKQVLARYPDTTTFYRAEVMGSRKDAYRLKFEGEEDDKEMEVDRRFVLDIPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Z5</accession>
    <name>A0A5N6U6Z5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PrpF protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_147681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Z5"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30825" checksum="F16A9BB23C8C037E" modified="2020-04-22" version="1">MFNTFRQIDIKVFNTNTQQCLVETIQITPDGKFSEDGEYSIPGVRGTASPIRMSFLSPCGSVTGRLLPSGAKQELLTVSSARSRTPFMVRASLVDAANPFIFIDAATMPPLYHHAGVGSSISLEIIEEIRVAGAVRLGLAKDIAAASRTRGTPKIALLYPTTRPEATGISHNHADIEVRAFSLGKPHPSFQLTGAVCLGVALSTPGTVAWELWKQGGPGSSNFYPSLPQKTEPDTLKWLIKHPSGVMDAEVKLSLGDDGDRVVERVSVFRTARRLFEGRVFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7J9</accession>
    <name>A0A5N6U7J9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">POT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_172057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7J9"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="590" mass="65968" checksum="2990D024F4220AAE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7K6</accession>
    <name>A0A5N6U7K6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_147627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7K6"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001196">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_1G12380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="374" mass="41476" checksum="7E51295D5D8395BC" modified="2020-04-22" version="1">MSRSSHRDDFFQTTAALDEQKRKDLKSQNTNGDPIRLQSKILAVEADPLNPGAVFVAQSGGTVRKVILETGETAALYKGPTAPITSICFSPDGRLLFAGCWDKYVWCWDVATKEVKQKYEGHTDFVRAVVSTRLEGKDVLVSGGADAQILVFDIATGQRLSILKGHAKGIQGLAIDPVSLESDDQEVLVFSSGSDREIRHFDIAGGSKDLTGTDAILAHDTNVYRLLFDRDGDLWTASADKSTKCLVREDDWKPNLTLAHPDFVKDVVVYEQGGWVVTACRDEEIRVWNRSTGQLHHTFSGHYEEVTGLILQGSTVVSVSIDATIRRWSLKPEELQTAVERAKKPSTEEEPEQKPTSMLTEEEERELAELLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7R0</accession>
    <name>A0A5N6U7R0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_126349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7R0"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="182"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="453" mass="51376" checksum="7792A8133921815B" modified="2020-04-22" version="1">MLVTTRNWYLVRIVPAIVGAFSALCIWVLWFGANSDRDNVPSLVNHLIPAGHCACRTAVSFQCASCLQCAATTPISPSPAERTYNPVYDAHNRSLDASQCQSFFPGLYEDIHRAESFWSTKNNITRHELDDIHLVDGMARAAIVQGQLYVIAARAKGEDHRRKILGTLASINRALSSSRATSLPDTEFIFSIEDKVNDVTGPNHPLWVLARKAEEEAVWLMPDFGFWAWEHGGSESHIGPYTQVVDRILDNNVSWDEKEPKLVWRGKLSFAAKMRRALLEAARDQPWGDVKELDWHRKANFISMEDHCRYRFIAHVEGRSYSASLKYRQACGSVVVAHQLQYIQHHHYLLVSSGPEQNFVEVKRDFSDLQEKMQALLDDPAAAERIARNSVATFRDRYLTPAAESCYWRELLSGWTAVSSHVSETVSSSQLVRRGMRFESFVLLPSQDMLHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8F6</accession>
    <name>A0A5N6U8F6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_82969</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8F6"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="245"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8154866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="608" mass="68102" checksum="0BD77381E47ECB2D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8S5</accession>
    <name>A0A5N6U8S5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_146814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8S5"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="578" mass="62754" checksum="03B4943945B0DC12" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8V7</accession>
    <name>A0A5N6U8V7_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_170332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8V7"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="542" mass="59844" checksum="9841A789E865E649" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Z6</accession>
    <name>A0A5N6U8Z6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_37817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8Z6"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="185" mass="21189" checksum="05B34D4E338B9B2D" modified="2020-04-22" version="1">MDDPGDHNNLLQDLLYVMRSVDESHAQELFALMRADASIPQLRAFIDRTLSEVQVTTGEEEKIHRLGQVRNRVDVESGIPPFRPKVMDVQYLCDIAPFRVPAHPWTTVTDDDALVSHLVSLYFTWDYPFYAFVDRKAFVHHMVRGNVDSDFCSPFLVNALLANACVGLFPFPFPPHPPIPRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Z9</accession>
    <name>A0A5N6U8Z9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
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        <ligand>
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    <sequence length="546" mass="59640" checksum="2DFED5BA6F41FC37" modified="2020-04-22" version="1"> </sequence>
</entry>
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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</entry>
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        <submittedName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="430" mass="48070" checksum="FCC357B6C7766B60" modified="2020-04-22" version="1">MSRPGNQQKLNVAIIGAGPAGLGAAIEFQKLPFVNLRIYEQARGLREVGAGISIQRNTWRMLDALGVYDNIDPNTIFRAADGHSVQHRNGRTGELVVSNGQRDTPQRYKHARALRTILQTALLKGIDQSKLRLSSRLIQVSELPNKALSLRFEDGHTDEVDLLVGADGVRSVVRQFSFPDHRINYTGVTAFRALVDAQEILSIPNFPDAVTFWHGPTRWVYTCNLNNGIYEVTARTDVPETSQTASWGQDASTDEFVGLYKEFAPIIKEVLSKVKEVKKFPLFAGPRLSRVISHGSIALIGDASHPLSGAFGAGAGFALEDVYVLARSVNWAHERNRPLSDALELYDRIRSPHYKGMYDILDGFRRSDASGKELTLFDDIVASNIKNKWTDDHYWLYHYNVQEVWEKTYQAEDAKQQGNASRSSEVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9Y1</accession>
    <name>A0A5N6U9Y1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-Aspartase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_146392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9Y1"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="671" mass="73150" checksum="9E0FC0C75E8D32E4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDD7</accession>
    <name>A0A5N6TDD7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742764">
        <property type="protein sequence ID" value="KAE8144141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDD7"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="148" mass="16496" checksum="00D3F6E7AF1C9569" modified="2020-04-22" version="1">MDVASSQSSKSKPRATASCHPCRTRKVKCNRLSPCEACVTRGIPEECKYSAPNEDRQAIAQADMITELRGKVNRLREQIAQRGAYRCSSVSSEEDEEEAAAMEIVYSALRLGPEDLVWKLVGRIREGEDVRELARDVANYMGEDDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDK0</accession>
    <name>A0A5N6TDK0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742515">
        <property type="protein sequence ID" value="KAE8144458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDK0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="174" mass="18270" checksum="A14BDBD693AAE7E4" modified="2020-04-22" version="1">MSSKDPLQELEDIQQQQAELQKQATALVGQIKNQPSSKAQANDGPNPSSQHHPFPGSSPEHGSPAQTNSFKRVLSINPNSGLVQTTYYASPASPDGRPAPDDFLRSPAHSPTSPAYDLDSRPNENALWVTPLDPPAPSSPGDRASRGCSPVSRAFSPPSPSGLVSDGHDLASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDP8</accession>
    <name>A0A5N6TDP8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_166952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742540">
        <property type="protein sequence ID" value="KAE8144396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDP8"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="620" mass="68924" checksum="B4FB616C06C11AD4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDR7</accession>
    <name>A0A5N6TDR7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_166653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742495">
        <property type="protein sequence ID" value="KAE8144515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDR7"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="11">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="COQ9 C-terminal" evidence="10">
        <location>
            <begin position="199"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="297" mass="33469" checksum="0487A403E50FADCC" modified="2020-04-22" version="1">MAHPHLTRLQAPLASCKRQLPPTFRLTRPISTSRRLYQPQHQHQHQHHQTGNQRTTSPRRTQTSSIRKYHSEHHPELPPHEYTNSQTAILSAALRHVPAHGFTRDALTLGARDTGFLDVSVQLFPRGEFDLILFWLASRRGLLRASVEDGLFETDTRGQRLSVAEKTKLLIMERLRMNTDIRHQWQDALALMSLAGNIPLSLSELHALSSEILDLAGDTSVDASWYTKRLSVAAIYASSEVVMTRDRTPDLRETETFVDRRVEDSKAIGDKLSGVKQCLGFMGSTAVGLGRSWGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDY8</accession>
    <name>A0A5N6TDY8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Carboxymethylcellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_166504</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="ML742482">
        <property type="protein sequence ID" value="KAE8144583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDY8"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024992607" description="cellulase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="16">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="335"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8144583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="484" mass="51625" checksum="A2A783AED3621608" modified="2020-04-22" version="1">MRIGNLVLAASAASLVNAYPTRDIKKRGSGFTWVGVSESGAEFGQTNLPGTLGTDYTWPDTSKIQTLRNDGMNVFRIPFLMERLVPSDMTGTPDSTYLKDLKTTVKSITDSGAYAVLDPHNYGRYSGSIITSTSDFKAFWKTVAGEFASNEKVIFDTNNEFHDMEQSLVLSLNQAAIDGIRAAGAKTQYIFVEGNSYSGAWKWANTNDNLKGLTDPQDKIVYEMHQYLDSDGSGTSETCDSATIGKERLQTATEWLKTNNKKGFLGEFAGGVNEQCESAVKGLLSYMSDNSDVWMGAEWWSAGPWWGTYMYSMEPTDGEAYSTYLPILKEYFPDGSASSSAPSTPSSTATSASSTATSAPAFTSTSDAINPPTAPTKVATSSSAPTYTSVTVSVPTSTPTTMSTSTRCGKSGKTRTVKVTATPSTSAAVSTSAAATPTSAATPSSSASVAAHYYQCGGINWTGPTACASPYTCVKQNDFYYQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEE7</accession>
    <name>A0A5N6TEE7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742456">
        <property type="protein sequence ID" value="KAE8144677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEE7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="112" mass="13182" checksum="141399082CF9A706" modified="2020-04-22" version="1">MLVPLGDGCFLVLNDFLKRRHVFFCFAMFSLFSFISLNYSIHHCFFVPLSLIHFSLEAFKFMVFGLELTLEFSVLIMNTLNGVKSRRGSQSLEFVEESYYDLRVEALRCAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFA0</accession>
    <name>A0A5N6TFA0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative serine esterase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_165514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742395">
        <property type="protein sequence ID" value="KAE8145045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFA0"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="468"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="947" mass="104584" checksum="F53333ACBF757F50" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFE8</accession>
    <name>A0A5N6TFE8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_78208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742392">
        <property type="protein sequence ID" value="KAE8145062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFE8"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="198"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="965" mass="106229" checksum="BBA2DCAE7A198BAB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFH5</accession>
    <name>A0A5N6TFH5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_165316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742383">
        <property type="protein sequence ID" value="KAE8145124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFH5"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000002">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8145124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="611" mass="67393" checksum="3174A34F393B1D5F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFL1</accession>
    <name>A0A5N6TFL1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="8" type="ORF">BDV25DRAFT_170749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ML742379">
        <property type="protein sequence ID" value="KAE8145158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFL1"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="310" mass="34273" checksum="71CD3B18712FF85E" modified="2020-04-22" version="1">MAEDNHPSHLSPSELGTKDYWETFYARTLTHISTKQPNPDAPTTTEPTEPTSDAESVDDDDDPGTSWFSEHNAPDKVLQFLTSEDFPLAPCNTQGSDSQPRILDLGTGNGSMLALLRKRGGFVGGMVGVDYSGRSVELARELQRLKIHSAYLTDSESEFESESETGVEGEGGGGGEEIRFEEWDILRGEKELGDGSLAWFPYVRGGFDIVLDKGTFDAVSLSDEVVKDQGRKVERRVCETYPGIACRLVRKGGFLVVTSCNWTEEELVMWFTRESGGGDRLVAWGRVEYPRFRFGGQEGQGVCTVCFQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGJ1</accession>
    <name>A0A5N6TGJ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_70884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742345">
        <property type="protein sequence ID" value="KAE8145446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGJ1"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="710" mass="77955" checksum="FB54FBEE529BB751" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGK4</accession>
    <name>A0A5N6TGK4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_164594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="40113" checksum="D4EC4A4DF01F0D6B" modified="2020-04-22" version="1">MTSPYHRRPIPDYFLASPLAAFLYPLHHLLLRLRGPPRLPAPDTHPIRIVCISDTHSLEWTDIPDGDLLIHAGDLCNDGSVRELQAAVDWLRGLPHPHKVVICGNHDSYFDVRSRLPEDRDKSFATVSSSTASIRSIDDLESPHRIDWGDIHYLQHSAVTLSFQPPSSSPISRARSLTIYGAPQIPALVPFGPEHAFTYPPHYDAWSGTVPQNTDILVTHTPPQSHLDLSPVYSTGCPFLLTEAWRIKPALHVFGHIHAAYGSEPVYWDEAQKAWERLCASRRRRTRNTRLSSLFGFLRDLFDLSGWVDSTRVVVYGVLGVVWAQVWGGENSGCGWMVNAACMARDSSGLVNKPQVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THI3</accession>
    <name>A0A5N6THI3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_144533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742333">
        <property type="protein sequence ID" value="KAE8145561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THI3"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="148" mass="16148" checksum="6AC2E2224F3F8904" modified="2020-04-22" version="1">MPQLAWIGLGNMGRVHPPTQITRKQLTIHRAWPAKASQLKVLGNTFVIGMTRCTGSFEAVFPGPYVAYSARMRGGDYHRRREPLFGAGLVGKDARHALEMARSVGADMKGLVLADEYLATVQEVMGQRGDLAGIYGAVKMEGGLEFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THJ0</accession>
    <name>A0A5N6THJ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_170187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742308">
        <property type="protein sequence ID" value="KAE8145838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THJ0"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="3">
        <location>
            <begin position="239"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="322" mass="35888" checksum="540448CF7EC1D3EA" modified="2020-04-22" version="1">MPPSPLTTVYKEKLSSKITTDIYLPNPNGLTHKKYPVLINIHGGAFMLGHSGMVSMPQIDDCLARGWIVVVPNHRLCPGVNILNGPVEDCRDLLAWVYDSLEEFLRQEGKGEYGVDSEKVMAFGTSSGGFLALALGYDTIRPPRAILNFYGAVHFTHPFWRSPLPKMLSSIPQFPEQFLKKVYDEHPVPTDSSISLEGQMESGRSSGPDFSRPRDAFALTQIANGRVLDACFPGGDVRDIDPVHRVREGFPPTCVVHGAEDSKVPVFLSYELLRVLRGYGVECEFVEVPGEDHTFAMGMQVGSRTWELQRMGFDFLERVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THK1</accession>
    <name>A0A5N6THK1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_164259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742328">
        <property type="protein sequence ID" value="KAE8145619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THK1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="55" mass="6234" checksum="131975146E0C0D66" modified="2020-04-22" version="1">MPSQWSSVIFRLELQGRIPGHDRTKIDQLHMITAMTGDLSKHSQDGEDMPPISFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THV6</accession>
    <name>A0A5N6THV6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_133432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="ML742308">
        <property type="protein sequence ID" value="KAE8145840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000022">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000354">
        <property type="entry name" value="DUF1716 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1795" mass="202548" checksum="7EFCF12C03CECA05" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI24</accession>
    <name>A0A5N6TI24_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acyl transferase/acyl hydrolase/lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_163579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742302">
        <property type="protein sequence ID" value="KAE8145910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI24"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="198"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="602" mass="68473" checksum="329B243FA6CCACDB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TID4</accession>
    <name>A0A5N6TID4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742286">
        <property type="protein sequence ID" value="KAE8146106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TID4"/>
    <dbReference type="OrthoDB" id="5126078at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="38012" checksum="DE0D80ABB2D66C1F" modified="2020-04-22" version="1">MKPNDIVYGLITWANQESYNNARIPFPPPPDFKRPKENTAVEVLENILTRVIFAGDEKYDTVFINSQCPPHVNSAMRADLAIKYITHAHRLQIACFIEAKRTRESQRYSTMAVEDEALDYCGEFFSDRSNTCDFVYAATLVGVHIRLWIVYNDDRKLESLWGSPNRGSNNDYKDLGDNASAELIMSAFRNILESAPKPWIGRSSSSAPPTSTTGAFQLARIEPNAANLPGPQFPNITRGSSTGSSALVPIHPEVSVGPVLQASKGTPTTSENCAPFPPRGYARVMTFLPSTVADRYIWMLSNNVTGNGPPSDWIVEDGYFVNSKQKLYADPTTKRLPQEAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIS0</accession>
    <name>A0A5N6TIS0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_143904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742278">
        <property type="protein sequence ID" value="KAE8146217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIS0"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="585" mass="64580" checksum="2FACEB1C1E5A1C4C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ14</accession>
    <name>A0A5N6TJ14_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_133220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742287">
        <property type="protein sequence ID" value="KAE8146091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ14"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="483" mass="55201" checksum="342A96C7BDC4E92A" modified="2020-04-22" version="1">MEIHGSEIQDSVTTVCFIYLLYCAFQYWQRYSYDKSFGQKHNCLPMETWLPYKWPLALDVLKRQYDAPPDQRLLLFMSQYFDRVGPNMTFKLFGNQGYFTADPKNVESILSTNFEDWGLGSRRPGLMPMLGEGIFTQDGRLWKHSRELLRRQFVRIHHQDCRIFDEHIDDLIRELRFARGVVDIKSYVFRFTLSTTTALIFGESIVSLPGEETATFESAFDYASYISAIRLRLAQFEWVWKPPKFQEACAVVKDYADKFVQLALDDMVKNGEHSASETHAFIIDLYKELRDPVLVRDQLVHVLIAGRDTTAFTTGESSKITRALIGKMEYLRCVINESQRLYPQLPINVRQSVRTTMIPSGGGPDGKSPVLIPKGTGIGYSVYHMHRLKTLYGEDANSFRPDRWLGDELNGIGWGFMPFHGGPRKCLGRDFALTEASYAIIRIIQAFPGLRLPPELTVVPPGEEKQSLTLVVSSAEGCKVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJJ1</accession>
    <name>A0A5N6TJJ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_132876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742258">
        <property type="protein sequence ID" value="KAE8146502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJJ1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="232"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="254"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="685" mass="75243" checksum="11D5490E5CB7212E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJJ5</accession>
    <name>A0A5N6TJJ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_169963</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="ML742274">
        <property type="protein sequence ID" value="KAE8146279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJJ5"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024811724" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="16"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8146279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="452" mass="49788" checksum="D62F1A173397C419" modified="2020-04-22" version="1">MNLWLLTLWVTFAAAWVDNQGTTCTLYPESLTHHGQVVDDSPSIQQAFDLCGTNGTVIFTENVFHVNTVLNTTNLLNCHVRLRGELRFSTNIPYWRTHAISVVLQDQVTAWLFGGHNVTLTGENGGFYNGQGQAWYNANRNESNQAGRPISFTVFNSSDLVVDGLRIIQPQFWATFVWASRNVSFTNLFVNATSDSEWGTMNTDGYDSWQSDDLLVENATIICGDDCIAAKGNTTNLLARNIYCEGGTGITIGSIGQYPETPDYNLNTTFDNVTIKHAMDGAYIKTWQGTRIFTPSNGDWGGGGTGLVKNITFRNFDMEDVGLPIQVAQCVYSAGSNKSCNTSTLQIEDVKWENIRATSRFNIASSIYCSDERPCPNMSFENVNITSLNATRGQAYYDTDVQYELFQCSNVLGVNGSGIPCNQAAPSNFSQWIYGNVDSSGWATAVSDHLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJL0</accession>
    <name>A0A5N6TJL0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_49642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742260">
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        </location>
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            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
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            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31002" checksum="426F1B4FD825EFFD" modified="2020-04-22" version="1">MTGRLGYEGRPERQNEYFIPGDGISREVIQADICRYLGNDALVRPGNHNGRQGYFIRAYRNLTSEMIADLKADSARWEADVLRRADQGYPRGSYLQQSVSQPPNMVPTTYPPTTTIHETRTQQGPSPPPAYSAPPPPQSYVDPYTQPAYGQTQSPPYPAASSYPANHSPFGSGQTYPPPQLPYTAPSQPPVSTDMHQTYTYTTTAGYGFENGRNNPRYPGPSYETEPDYSPVTSGIAYPATTAPDPRIGGMDPRYTPESAYSDRSRPQPTRERDPARRR</sequence>
</entry>
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    <accession>A0A5N6TJQ6</accession>
    <name>A0A5N6TJQ6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_52242</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742269">
        <property type="protein sequence ID" value="KAE8146339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJQ6"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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    </dbReference>
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        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
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    </dbReference>
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        <property type="entry name" value="STAG"/>
    </dbReference>
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        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1203"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="43"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1116"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135176" checksum="11A709EFEC1D16BA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJS8</accession>
    <name>A0A5N6TJS8_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_162196</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742253">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="268" mass="29310" checksum="9B533D2F5DED0C76" modified="2020-04-22" version="1">MSSNPPSPRLDHIVILVTYATLETLSERLQQWFVIAPGGTHADGLTANKLILLPDGVYLEFIAFVRDVDPDRRRNHRWGTQTENTIIDWALTLPTERDFPPVQQRVQASTSGFKYQDLVAGGRRRDDGTILEWVISTAIDSLGDATPPGRLPFWCLDRTPRGWRVPYQEQPDLIQHPSQVLGISSVAVSAPEAQISGLAAAYNAISAPGDLTTATTRDWHYEVPSGSPAGKRTISLSGNGQGTNITFAFHGPVPGRIELLPGLVLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKK6</accession>
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            <fullName evidence="13">C2H2 type master regulator of conidiophore development brlA</fullName>
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    </protein>
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        <name evidence="17" type="ORF">BDV25DRAFT_143290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742238">
        <property type="protein sequence ID" value="KAE8146886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000845">
        <property type="entry name" value="C2H2 type conidiation transcription factor BrlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0183">Conidiation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0749">Sporulation</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8146886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="417" mass="46578" checksum="FE5D2728F1726B3A" modified="2020-04-22" version="1">MRAQNNLTLDVDRSSLGSNECPSMISSFSPMDSPTPTPTTIYSQESLASPVWQDAGSYHSHGYERHTGATPMRSASRMAGMTLNENMGLPYGSMDAQDRMHINDFLPAYDENVEPFWIASDAPKTYETGTHGLPYPPTMPQCPPMVRSSYRPHAPYLSESASNPCLARSIFHQPERVPTSMSTMLPWMPQPTESIAPQTIAPSQVGPVTPPPSYNEFPGSLHFKTHSPTTPVRSCSLGTASGPDTPMSRLSGGTGDYLDDFQQSPYRDGLHRLQRQSSRKVLRKSSSRQNMTLENLPSIIKQVQFKCQEPGCKGRFKRQEHLKRHMKSHSKEKPHVCWVPACHRAFSRSDNLNAHYTKTHSKRGGRNRYVATLDETSPDFDPEFRGQLTPDGRPIRGSTLDDPLPDAREYSVDVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMB0</accession>
    <name>A0A5N6TMB0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_36220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMB0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="76" mass="8439" checksum="AE886766D87D31F7" modified="2020-04-22" version="1">MDMLVWLSLAPTGHPLQDRASRERSLVAPASTYVPLVIPHTPVTLNISRYGFGLKGSHESRNSCFRITLGRDHPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMJ1</accession>
    <name>A0A5N6TMJ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FK506-binding protein</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_160622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMJ1"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="385"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8147329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="471" mass="51737" checksum="DF5B7D93F6CFFD26" modified="2020-04-22" version="1">MSGIQPVAVYALRVPPGGALVPALPEQAAAMFRVSMAAIDPDEEPDFDGLDANKRPRATLKIIRAPPGMDMDESDDEDYEDIDSDEDSDDEELNGGPSDKEKARKLKELAALKEMEMDEDDEDDEDEEFDLKAAISKLVKGKGPATDDDEEDDDESDEGLEVEEMVVCTLDTEKNYQQPLDLTVSEDEQVFFKVTGTHTIYLTGNYVMPTDEGRSPYDDEDEDEDNYDLSPDEDELDMDELMGEDDEDDELDDLENPRITEVDSEEEAPKLVETKGKNKRTAPVEEEEKPKAKQANAEEALSKKQQKKLKKNDGNAAAVEQKKEAKEGKEAKKVQFAKNLEQGPTPSAQDKKPAEATTGTLGVKEIKGVKIDDKKLGKGAAAKSGNTVAMRYIGKLEDGKVFDANKKGKPFSFKLGKGEVIKGWDIGVAGMAVGGERRISIPPQLAYGKKALPGIPANSKLIFDVKLLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMR2</accession>
    <name>A0A5N6TMR2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_30620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742201">
        <property type="protein sequence ID" value="KAE8147567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMR2"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024991984" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12766" checksum="96B9CB36E5EAAA27" modified="2020-04-22" version="1">MTGHLSIVRTYLFLLGRSLAFPRTNKTRFLVRLAPGLFEGRVRNFNRLALVSFRAKSQPSYLHRGWIYKSPPACVGEIRRKEKAKEQGRTTTPLVIPVIIVVLLEANRSLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN46</accession>
    <name>A0A5N6TN46_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742193">
        <property type="protein sequence ID" value="KAE8147725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN46"/>
    <dbReference type="OrthoDB" id="5598843at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="140" mass="15331" checksum="70C8F6F8B65F481F" modified="2020-04-22" version="1">MSGPGDDRSHARWRGGRPFDQNRQRHSMHRTMSAHGNPRGGQAQNPSNNWGESRDQSGTGPAQDQHVPVRGFNAAEAKAALKKDPREPKPFFYKPNGKDVNRSGGPWGSKPNNMASGKDFFLELRKQVTSLRQGANVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN52</accession>
    <name>A0A5N6TN52_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein Cdc14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_131857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742194">
        <property type="protein sequence ID" value="KAE8147717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN52"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="32272" checksum="EADC95D7C00D4F3E" modified="2020-04-22" version="1">METLLAHSFDYLSSYEPSKVRKGLRQVEGLLAQICLSKSKQPASDKRRSLLSFGAPQPVPKALSELKDDPAFREFFKLQEGFQWNVAMRLVTCLEHLLGRGSNGINDLLILSTLDLIQGVLLLHPPSRTLFAREIYMNLLLDLLDPINCPAIQSATLLTLVTALLDHPANTRTFEELDGLLTVTSLFKQRATSREVKLKLVEFLYFYLMPETPMLPAGAASAGFQRSPTKLGGPLSRNANGPGAHHRRRHSRDTRTTDEKQSLLGRYLNNVEDLVEDLKETAPFGATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNE6</accession>
    <name>A0A5N6TNE6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_159954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742198">
        <property type="protein sequence ID" value="KAE8147629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNE6"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="101"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="928"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <sequence length="1177" mass="131286" checksum="745385486777329A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AIP3_C"/>
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    </dbReference>
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        <property type="entry name" value="SRCIN1"/>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="901"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="707"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110627" checksum="6FD1892DFA1402C5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP46</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_22664</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742174">
        <property type="protein sequence ID" value="KAE8148128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP46"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="64" mass="6999" checksum="C2C151464C50546F" modified="2020-04-22" version="1">MSPGLYCVTYSTGHFLFLVAHLDLLLGLELLLISMDSVMCPSPATVIFLCFLAFVAISFVILVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPD0</accession>
    <name>A0A5N6TPD0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_158812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742171">
        <property type="protein sequence ID" value="KAE8148174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPD0"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="50671" checksum="8464A5CD5FEC28FD" modified="2020-04-22" version="1">MAEGEPSYIDYEAFLDPEFSPASFANTLVVATNNATDTPLDLSTPLSRVLFDLQEIDTHIHTLTTKSALPLLTHTRDQTASAGRILKEAEDQVSSVTQGYERLQKEVLQKWESADEARIAAEKSLATVRLARAVARCLTLGRQLEGQLAEVTGRGGGLAAGIDASGPGRDDYRALERAASTIVSLRRMFTETAPGDEGYGLDRVKVIRTLRSELAIPAENMVKSRAQQTVNRFSLSTVSTGTSSHTQSGYKQARDARARFSSAVTILYLLSPIPKDLPSASSFQPELLLSTLHGYMHTAIMSSLNALSRSLSMLPTLEKALSDISAKCQDIFALESLLASLRPPSHPLFPPADFESQASKTTSNSNNNILQLLLGSLDTSSLPSYFWRSLASSLTSRVQEILNRGGVSARTLRSNRDRLKKDLKECVMRGSQLPASSIVAEKGLSASGGNWEREAAVMVSAVANVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ78</accession>
    <name>A0A5N6TQ78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_158218</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="ML742159">
        <property type="protein sequence ID" value="KAE8148485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ78"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024823291" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="307"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8148485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="818" mass="92790" checksum="B24F064A58C7E307" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQA0</accession>
    <name>A0A5N6TQA0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_131194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742159">
        <property type="protein sequence ID" value="KAE8148467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQA0"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="29824" checksum="F039DFA394CDEA6E" modified="2020-04-22" version="1">MAEPITLTYQDRIAIITLNQPEKLNALAPELYYELGERLREVDKREDITITVITGTGRFFSAGADVKANRADGIFNGARQSLTRSFLVNNLDITNTFAHHSKILVAALNGPAIGLSAALIAMSDFIYAAPHTFLLTPFSSLGLVAEGGSSRAFVERLGIAKANEALIMSKRITCDELVGAGFVNKVISAPSGRTDDSAGFLGRVLEEVKERLGEHLSQSSLLKIKELIRRPEREVLDRQSQLEAFAGLERFLSGKPQEEFRRVASGEKKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQA1</accession>
    <name>A0A5N6TQA1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_158265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742160">
        <property type="protein sequence ID" value="KAE8148454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQA1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="785"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8148454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="880" mass="96467" checksum="12D89C18281790E5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQG1</accession>
    <name>A0A5N6TQG1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_158113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">IBT 18842</strain>
        </source>
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        </subcellularLocation>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">IBT 18842</strain>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PTR2_2"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="627" mass="69709" checksum="C56A70791240754F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSG9</accession>
    <name>A0A5N6TSG9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_141004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSG9"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="43295" checksum="D13358A85645FD86" modified="2020-04-22" version="1">MPSKGDLVQLVNAIAYYGLISSLTPQVAAGGNSASAVQGGYTYGQPMPVTCLNRTIDSGEHVTHPHAPVDNKIQTLYPSTDSLITDSLGKLQYIPFPTCKETSAPLALRYGVTETISCTISSIPDEYYHLLEYYVHSDVPMNCRVPTAPLGVSVSSHPDESNPQEDTVGTELSALSDEGPPYTPITFALQGTLQRSHLHIWTDMNVLLHNIAATPKGNRKKKRAAPGYLVAGTAYSVPEFEVSLLESQKKTSDEDNEEGAVSEGAREPWTAGHGTKVIRGQPLTFTFHVNWIEGGKSIGWPHRASDMDESSAVMSFFSKIFFFAIATSLGAAMALYWERVRRRGWRGDGILGVRPRARGSVGPMYGNGGKINGYGGYSANNVSMTGNGSGYGYGGFASGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSS1</accession>
    <name>A0A5N6TSS1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSS1"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000016">
        <property type="entry name" value="Translation initiation factor eIF4E, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="238" mass="27675" checksum="B84277EFC06C4606" modified="2020-04-22" version="1">MALPKLHVNDASPISDDTTAKENAMDKQPSAQALPPTRKSLHQNIFGKLRPLPFQYHWTVWYDRHSDSADYDNRLYVLHEDVADIATFYRVYNNYPWEKVRLRDTVHIFRKGVRPVWEDHENLKGGCWKFRVPKSKAQEFFHEIAILCMANEFQAVLEKEHDHVLGVSTSVRFNTHLISVWNKLGSNERSIKALEQVILDRLSPELRPTGTGSNAYFYKRHDENEGFQDAVQRVAQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TST6</accession>
    <name>A0A5N6TST6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TST6"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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            <strain evidence="3 4">IBT 18842</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">IBT 18842</strain>
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</entry>
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                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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                <person name="Baker S.E."/>
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            <strain evidence="6 7">IBT 18842</strain>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV44"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="251"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="445" mass="48302" checksum="4D97E6985B0A0D7C" modified="2020-04-22" version="1">MELESRPQHSTTPDLSRSNLITDDSLGPPDEDQTESQLPPVDGGKHAYLFLAAGFMIEALIWGFSFAYGIFQDYYSSHESFKSSGNIAVIGTCMMGVNYLISPITFVLLQGLPSLKRWSCPAGFVVMCLALALSSFAANTTHLILTQGIAYGIGASFAYSPVIIFMNEWFVQKRGLAFGLMWAGTGVSGVVLPLVLQWLLDSYGHKTTLRIWALVLFLMSSPLVYFVKPRLPISRASSIRTFDLSFLWQHTFVIFQMGNIVEALGYFLPTIYLPTFARTLGANSIMASLTVILCNLASVFGCVAMGHLVDRYHATTCILISTIGSTIAVFLFWGLSVSLAPLYVFCVVYGLFAGSFTSTWPAVMNEVVKKSQLADPSIVFGFLSTGRGIGNVVSGPLSDALIKGSWSHEASSFAYGTSYGPLIVFTGITALFGGLSIIARPFKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV96</accession>
    <name>A0A5N6TV96_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV96"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024819557" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9306" checksum="8E514FCA24FC739D" modified="2020-04-22" version="1">MQITLTTLLLFVAVYSSIPHMMVAPCSKTEPETGILAISQLIFGQKWDVSFQIKKKKAGCFVYPLEGSIFLMPEMPRCPQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVK9</accession>
    <name>A0A5N6TVK9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_113401</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="ML742097">
        <property type="protein sequence ID" value="KAE8150327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVK9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF424">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
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    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
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    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1038"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="75"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8150327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1115" mass="121717" checksum="9739011966D8D84D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVN8</accession>
    <name>A0A5N6TVN8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_154543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
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        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
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        </location>
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            <end position="208"/>
        </location>
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        </location>
    </feature>
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            <begin position="259"/>
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        </location>
    </feature>
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            <begin position="47"/>
            <end position="285"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="41754" checksum="9E20DE95C41053DD" modified="2020-04-22" version="1">MASSTIVPAMNPPPGLTSNFIDPPYIGAKFVVVNAVFLPIAVLSLLLRTWTRLFVVRSFRWDDSLMIMAMLLSCAMTGITVDMLNFGLGKHMWDIPATYVSPWFLRRNVIAAILYCAATGFTKVSVLIFYLRIFPSRNFHIAVWVLVFIAAGYSVASVLANILSCTPVDKAWYPMKAGHCMNRPVFYFANAGLGIFTDFATVVVPVPWLRRLQMPIRQKIAVSCILAMGCFVGIVSCIRLSTLYTLLKSPDLSWSTTDALMWCTIELNLGITGGCITAIRPFVRRYFPRLLGLSSSSGYKSSSMSRKYGHPLGSIPRPNAPNFSNVHSNQYSTTATALDNESEENILQKPQPIATSPKGIGIVRTVEFDVEDGRGNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW28</accession>
    <name>A0A5N6TW28_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_110807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW28"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="139" mass="15636" checksum="4B86F227EE1F8A6E" modified="2020-04-22" version="1">MIGQLPLRPLAPKDELPPSDNDDGATKKGKRRRTSLACLECQKRRIKCGSGQPCDPCALHGRECVYDEYKDKRRKIAAELTQQNLHFYQEFVGSLLRAIQLGSPDNVERLINLIRQGAPLDDIVTMVNECLDQLPPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW98</accession>
    <name>A0A5N6TW98_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_112723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW98"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="72" mass="8165" checksum="1F5EC4B01F84419D" modified="2020-04-22" version="1">MILYLSTANDVVSEYADKRQDAYDLGCHSADLKRGLSSWKNQHVILGDRRYKRASIPLGHYHPITSVYPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWK8</accession>
    <name>A0A5N6TWK8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative SAM and PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_153840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWK8"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="190"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="657"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="813" mass="90733" checksum="E1C9B59CAAD3CAB3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWZ2</accession>
    <name>A0A5N6TWZ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_129292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWZ2"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="224" mass="24610" checksum="16B0DF2256C7D187" modified="2020-04-22" version="1">MSPNNLYQYSVISALMQGVARTGPTINQVLCHGDHGLGTVDHINGEVIVVDGLGVEATDVFPFIMMTHFKPTLSKRLPSLNMSNLQDGLSPLLPSRQNCFLSVRVDGRFDRVTFRVIPAQTQTREPLLALAQRQQMHSVENVRGLLFGFWSPSFTNGFSVSGFHLHFLSDDRSAGGHVTGFEAGDAKISAAVLKEYQVELPQDEDFHEVPIRGFGTDDMHAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXC8</accession>
    <name>A0A5N6TXC8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_171824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXC8"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001166">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_4G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="467" mass="50639" checksum="52B5ECF1F89765E7" modified="2020-04-22" version="1">MNSYLLNRTLGSISPHDFHVAQTSRLIHLLEPAPGIRFSSRNEVESRSAVDVNLNADAHPAHRAGVNVLAMDHYEGRYMVSGGADPSIHLWDLETRGAELHHTHRSIASVTKSSHADAHTHAITSVSIYPFDPVPSTILTTSRDGTLKLSALEPAAITPVHTFSLDCTPYAHSLSSHTASPLLIAVGTSEKPVRLLDLRSGLSTHGLPGHSASVLSVAWAPHQPHLLASASTDNRVIIFDIRRGGHNSAIATLDMDDAIGLVPPRCAPASYQSRPAFSPHGRAHNGAVTGVRWTSTGSHLVTAGQDARIRVWDASTGANTLVHFGPRVRNAVTSHLAERAPLVLPKGVTAPGQETLLWPNYNEHDERGEIFMFELREGTFIKQLKVPGLITARPQRGRSTALTAARINNLAWRGNGAAGEGIEMFSAHGDGTIRTWVSRDEPDEDEAEAEDRKRKRDVLDEIYKGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXH1</accession>
    <name>A0A5N6TXH1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BDV25DRAFT_153390</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXH1"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
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</entry>
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</entry>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="448" mass="50290" checksum="1D4B52D162FF39C8" modified="2020-04-22" version="1">MLTPIRVRGRRKKPPAALALTKRPPGRRLNRITEARRSRKRSKRAKLHHEPTPPAKRRTLSRLEALPVELIEKIFLASVNVNLPRASTVLAATVSSERIYRALVLLAFWNDDLVGGCSGEVARLLRPLDYVPLGLEARARLQGEIFRCKWCTVARVLGRLPEMMGLSVRRHWFDAGVVMVSGEEERLNRFLAREESEHGNGHTFTGTVNDTIHTLTISPPISITITDTATDSAQTHRILRITEFPVQLLTRPSFTPETTTYLEFLRLASGLNTSTLQETSVSISRDALQKGIRTALHTRNKDALATLLKLDEYYFRAQNTAITATQSPVYGLPAEHFRVAVRADDPGLFQLLVRASAESVPDDSEITAWAMELDSGLGRWVLDLLLHLPQRVEAARANPVEGAVFYMGRANAQVELARQYLSEVLGVEELGSWMEESSLDVRRLWRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY78</accession>
    <name>A0A5N6TY78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY78"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="40409" checksum="E1713E1BBBADF9EF" modified="2020-04-22" version="1">MSENESFAGYRWSYFSSMSEGPLRVRAQTFLDSIDWDALLRCASAKRNGVECRLLPDIGLGYNHMVRVVEFVDQVQWVARLRMPRVDGGDAGERIKSEYETIRLVQKESKIPVPHVHMLETDLDSHVGAQFMLMDCLRGNVGMDLSFSILPENKPDAYAAMAEVQIEMFKIRLPKIGKVVGVNDDGSYRLGPIPALGGPFDTAAEYFKAWAAKAEFGPFVDEILSSVSTFRKLLADNAEWLSVNNTGPFPLCHDDFGHNNIVFDDNYRLLGVIDWETAFAAPCEISGEFPLSISLIPPAMDAPWNYDETEEEQGLTEGYTLSSALQDNKRQYLASAMRLYQNGKAGWYSKVMEELRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYE4</accession>
    <name>A0A5N6TYE4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_97957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYE4"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="419" mass="46363" checksum="5ECC516AAFDFBADC" modified="2020-04-22" version="1">MKLPPAAVIASWPTPNYVDPPTRGNSVLIVTIVGLAMSFVVTCLRLYTRFKITCSPGIDDILIVIALIFAIAMGAVVSVATEHYGCNRHIWDVPLEWIPTDSKFNLIFQILFSISSSITKLALLWFCKRLLGTGSKGGLKLYNIVLILGMALVAALCIIFLFFCIFQCSPIHAYWDLQPDYPHRCLDEGNVVFAASVVNIFTDFLSTVLPMPLIWNLKLPARQRIAVISIFGLGIVVNIAGTIRTVYVYKSMVASYDTTWLGWPVFLAASIEINLGLICASAPALRPLVTFFLPRLLSSTRHYASGYGQSRPQKLNSTANPSRHSAKASKAASHQYTDSQLERLEVYRTIEMESWTEPKSSHPTHDPYELPANHTQVAAANFDFDFKNGNAVYTSPGSDKSSSSLTRETSSPFKDKHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U014</accession>
    <name>A0A5N6U014_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U014"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024864457" evidence="1">
        <location>
            <begin position="18"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="112"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="255"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="453" mass="51065" checksum="2453A745514F0405" modified="2020-04-22" version="1">MKIQLWSAVATASLCAGFVIPSQETLKELVTDDTEPSYSDLQTPDYETAPYIHHLDAVLDSFTDCDDDDLFFYDPVDDDDEDYYPELDDDDDYYYYPEDLPPLHPPHHPPSDKTIYELISESKYTTVLAKIVNEDDDLVNLLNSTKSNHTFFAPTDAAFEKIPHHPHQKPPAEIIRAVAKYHLVPGLWDATHVFHSHTLPTELEDPALNSLPQRLAIRVGWKGLTVNFYSRIVATDIKGSNGIIHGIDSILVPPPSTLAILNIIPTLFSTTVLALQKTNLTELLTSNNHGGTLFAPSNKAFEKLGFKLNAFLFSPYGTKYLRALLKYHIVPDRTLYSDIFYTEKGEGRPFGVKGYTHLDLPTLLPGKEVAVDVVTLGPYASLKVNGFRDVAVSDLLAKDGSVQVLDRVLIPPKEETEEDWVEEFMTVEELKSRLEDYLDGEKEEFEWPHETEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0J6</accession>
    <name>A0A5N6U0J6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease P 40kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_76767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0J6"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="372" mass="41427" checksum="0A761817D98C9D31" modified="2020-04-22" version="1">MFDLQDDASRREKCYTSVANLSAFVDPKHPPTKKAPFSTIWGHPFVHTVEVLLPERVYKTIQSSVETKLPKLRYARVFMSLSALLEGDFFNTYVKTGNILMISEGRSGSDNVFTLKDGVLKLELSKEIYERTGLTGKPIRSGGRKHAKERFIVEINLRLPSMLHGKKGFERIAWAFKNVLTHTVAWLFYDLASGSNGISDADTSLKGNHPHILESDPVRTDYRDILVPPFALWESTPEQELRDNCDEISEWLAMVSLGSPRVSSTDDIDPYLSRYSVPDASEAKPADIVSLKWRGLIPPKWVMGLFYHLLRETGKSSESSWFGISAGALGKEAVEGKDGYMVMVLPSDGAEGDADKSSQSAVCWEFVGASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0L3</accession>
    <name>A0A5N6U0L3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_138504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742064">
        <property type="protein sequence ID" value="KAE8151791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0L3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025041474" evidence="2">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="150" mass="15997" checksum="0A9C0FDB42F08A6F" modified="2020-04-22" version="1">MRIGLFLTLSATATALPAWGPVRNGTAPGLNPSINAVGHSIKDTFLGKNNKDESYNQKTDESKTYAPNDDHSKTYAPTNSTDDRDYSTNDSFNEKDSNNQDKSNHPQVVESLLDSANVTINGPLTTAPLIDADGTLLSLPSFLPIAGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0N8</accession>
    <name>A0A5N6U0N8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_138201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0N8"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="148" mass="16533" checksum="0BDF0D070DDE5AD7" modified="2020-04-22" version="1">MGGVTVRDVDAQKFIGAYSAFLKRQGKLPIPGWVDTVKTSCSNELPPQDADWYYVRAAAVARHIYLRKTVGVGRLRKVHGSVRNRGSRPNHHVDASGSVDRKVIQSLEKIGVLEFDEDKGGRRISQSGQRDLDRIAKTTVDEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0Q2</accession>
    <name>A0A5N6U0Q2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_75189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
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    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
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            <end position="344"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152193.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="518" mass="59335" checksum="DD0EF5A05B352181" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1A9</accession>
    <name>A0A5N6U1A9_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_151074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152413.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1A9"/>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="190" mass="21466" checksum="9189878D89F88F82" modified="2020-04-22" version="1">MMRERIVVRSTFYHVGSTTPEQLLVSRLKSAAKKVTRDVEVLFSNDLIKDLIYDEASINDHNISEILSIIDEGRDNIIQSFGTTSLRCISYLILRPNVETYQDKGLYLLLDASLSNVERNQDGEIGSGVSSEIGASLQQRLISVLYQLFIDENQYNAHRRLAGKLLTELMLESQDGGNLLARFQEPTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1H8</accession>
    <name>A0A5N6U1H8_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="1074"/>
            <end position="1106"/>
        </location>
    </feature>
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        <location>
            <begin position="1107"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1326" mass="148067" checksum="D193725A7FC5B16B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1T2</accession>
    <name>A0A5N6U1T2_ASPAV</name>
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        <submittedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_170235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8152584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="295" mass="32074" checksum="F8C3BBBCC222C356" modified="2020-04-22" version="1">MEAKASNESFKLENLFNVKGKVALVTGGGSGIGLMATQALAVNGAKVYISGRSSEKLDRVTELYRKNLPGQIIPITADITDKSSVDKLVKEVSSREKYLSILINNAGISSQKQNTELEDPEELRKELFENTLDVKEWDDVYRTNVTQLFMTTSAFLPLLQKGSEQEEGWSSTVINITSISGIIKVAQHHFAYNASKAASIHLTKMLAHEITSSGLRIRVNNIAPGVFPSEMTAGKSDEKQKSGIPKEKYEGKVPAARPGKDEDMANAVLFTTTNQYLTGQTVVVDGGYVLATGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2C3</accession>
    <name>A0A5N6U2C3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_137590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2C3"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="54469" checksum="F4EEF128999A7BBF" modified="2020-04-22" version="1">MGPTEPKSVTSTKDAQDAASCKDAPTGTSDEQPQTPYSVLSERERIFTICISSMTTFLTPVAANMYLTALGPLARDMHVSDYKISLTITIFKIVEAIAPLLPAGYSDRNGRRPLVLASISIYFASNIGLALQDNYAALFVLRCLQAFGSSSLSPLSFATVADLVPRAERGRYMFYSMLGMTVGPAIGPILGGVLTQYLGWRSIFWFLTISAGVLICAILLFLRETCRAVVGNGSVPPQSWNRTILQIIRPNNQALSQHESQATATRPRLGIIATLLIVLERHVSLLAISSAVSFGGTTAILTTLPILLERKYGLNSLQIGLCFLTFTLGAIACRWNTGILVDRNYKRHARMIGANLQSNQELPVDQRLFPIEKVRLELTLPFLYLACLSIIAYGWLMEFDVHLAAPLIVLFVLGNASSGTINCINNLAVDLNPHRPAATIASMNTAKHLTAAGAVAAAVPLIDAIGIGWTATLVAALCGLVSLTLWVLYAKGQGWRQKGVSEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2S3</accession>
    <name>A0A5N6U2S3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2S3"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32237" checksum="95FBFE3EB57036A3" modified="2020-04-22" version="1">MTIDLQSRRITLVGATGSLGSEILSALLASGIHHVSVIARPTTSKGFDDRVTVHHADFEDVPALDVLIMALNPESYPRQIPPIRAAAEAQVRYIVPTEFGSDPTHETLNREIFLARMQTPFRSLIEELGVSSWIGVVNGLFFDFNIRNGFWGLDLQNRKVMLYDDGQVKINTSTLSMPEPFVRKHRNNWVFFSSFLVSQLDVFESAMRVSGTQEADWEVVKVNAKLAAENAKKSMQRGDQMAIFRLLFALTFQEGFGSDFSRRLIDYQEMEMAAPCLDDVVKKLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2W1</accession>
    <name>A0A5N6U2W1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_150881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2W1"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="275"/>
        </location>
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            <end position="381"/>
        </location>
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        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="854" mass="93833" checksum="4BDD6662CED4B70C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3P3</accession>
    <name>A0A5N6U3P3_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3P3"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025034225" evidence="2">
        <location>
            <begin position="17"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="456" mass="50344" checksum="C139D61515CC62B9" modified="2020-04-22" version="1">MIALLVTLLSGTPSLASRDSFYPPLNHTTFITNSSLGTYGGIYSAPGDQPSTIGDVYNYCAMPHPHVDTYALPPPVANNSVSAKILYLEYLQRHQRRTPYNLLPGGENQEYNCDSIHPHLFAAPANPGTPPAAVYGQAYSDSSNPFLTTYVKGTCQYPQLTIGGLLDGYQHGRDLRAVYGDELGLIPDSPTDQVWFRSSSAALTQGSAGGVLRGIFPDHEGPIPLHQQASGIDTVNRGFPCSARDRVLSAIQSTAEWNEHLSVTEQLRTRLSTMFNATSSWTSTFDHFADNFQARLCNGYALPCRVEDRSDCVSTEQANEVFRAGDWEWNYWWRRNANATQYIQLVEGLFLGEIVRKLEAVEQGTSDLVYSHNFVHDGDIGPILGALGIKALRWPGMASNIAIEIWQTATTEYYARVLYSGSAIETVHGTLDWIPLTRLIDILKPFLPDDIIAMCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3V1</accession>
    <name>A0A5N6U3V1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_137061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3V1"/>
    <dbReference type="OrthoDB" id="4510909at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="29466" checksum="101D61F8FB880BDF" modified="2020-04-22" version="1">MDFAAWEAAVNPKVQGALNMSNAFQQKDLEIFVMVSSVSSLCGNAGQTNYCAANGFLATFAAQRRAMGLPASVAILGPVNDIGYVAGASEAVHRQLDKYHSYRLSEAELHTTFAEAIIASRLQSGVSPEIMTGLRYADLSAPEEDRAPWVANPRLSHLVTDSKSMKLASTATDFNTPLRDRIDAAEIADDAFQAIVGSLAVRLGQMAQKPSNEINPDLTLVAHGMDSIMTVEVRAWFLKELQGDISVLQTLGNYSLADICHEVLERHNEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4C4</accession>
    <name>A0A5N6U4C4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_149739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4C4"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="356"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="448" mass="50640" checksum="868FE3F32E91D9A6" modified="2020-04-22" version="1">MKIKALSRPTASQQAPGSAVVRQPRNLDPAQHPFERAREYTRALNATKLERLFAAPFLAQLGDGHVDGVYSLAKDPGSLERFASGSGDGVVKVWDLTTQGEVWDTQAHENIVKDICWTPDRKLLSCAADKTVKLFDPYNSSSDAPPLATYLGQGAFTSLSHHRNQPAFAASSSSQIMVYDLSRPSSTAAQTLNWPTSIDTITSVAFNQTETSILASTGIDRSVIMYDLRTSSPVHKLVTRLASNALSWNPMEAFNFAVANEDHNAYIFDMRKMDRALNVLKDHVSAVMDIEFSPTGEELVTASYDRTIRLWNRAQGHSRDIYHTQRMQRVFSAKFTPDNKYILSGSDDGNIRLWRANASDRSGIKSARQRSKLEYDQALIQRYSHMPEIRRIKRQRHVPKPIKKAGEIKREELSAIKRRQENMRKHTRKDKLAPRQSEREKMILAREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4D4</accession>
    <name>A0A5N6U4D4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_127253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4D4"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000025">
        <property type="entry name" value="Related to Dibenzothiophene desulfurization enzyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="279"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="445" mass="49241" checksum="700DAF6E1EEEC9C7" modified="2020-04-22" version="1">MAQSNLTILTLQNHPPPSPPPPSSDPAIYQVHHEAFATKGQPTTTAGWLERARKVSDILAPDASARSKEQKIPRAEVSLLKSSQLTRVLGDAKHGGGGETWETGYKVIREVAAGDGSIGMLLGYHLLWSVTARIVGTDEQRERFDKLIIENNYFVGGAVNPRDNDSRVTRAPPGDGLVFNGFKNFNTGGVVSDLTVLEGVYEDTEEHIFAFVPTNQPGIIFSHNWNNIGLRLTESGSVRIDNVPISWEDALGWSKETKAPIPEVLQTPFPSLLLPTIQLVFSNFYIGIAQGALRTARHYTLTQTRAWPFAHDPKSTPTDEHYILARYGKFLASLRAADALADRAGREVSDAFIEHGAKRDISPRRRGEVAEWVASVKVVATHTSLEVTSGVFEVTGARSTAEKYGFDRFWKDVRTHTLHDPVAYKESELGRFFLLDEVPNPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4E8</accession>
    <name>A0A5N6U4E8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_149683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4E8"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
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            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="363" mass="39780" checksum="C5059E98F925EE19" modified="2020-04-22" version="1">MSEKIPGSTLNTVNLVTQCLCIPIVTIFVVVRFSIRCWYKQFVIVEDTFCFLAWLLFMAYCATGIVVGNYGGGVDNDLIPEQYHVAFRKFCYVATVVYCPMILFTKYALLSIILRIFAPYRGRMMFIYGLLACLTIYYVIAEVVKIRMCDPVPAYWTGAPASCLDQRAALIADSVISAVTDAIILVLPLPLTWSLQMSRSKKLRVIGMLSAGGLATAFSIYRLVLVLHDGTSANVSVFFTCVILSGNAEGGVGLICACLPTLNILLRKLRVLGYSYNSNKYYQGESSMHLSNMKGANGKGFSAIGSKLSTADRDTDFGCDQSHLISYAGAVETGTTHDGGIHKTVDVSQTVEVLKDGERDRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4H8</accession>
    <name>A0A5N6U4H8_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_127267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8153472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
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            <end position="90"/>
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    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="35"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="425" mass="45259" checksum="5AF4D624CEC056B3" modified="2020-04-22" version="1">MVPEEDRELSTLEMADSSELSCTGDYPEGGLRAWLVVLGAWCAMIPSMGLLNTLGILHAWTNTHQLQEYSESSIGWIFGAYGFFLYLAGAQAGPIFDMYGPAYVVIPGSVGIVAALICFSFSEEYYQIFLSFSVLGGLSACTLFTPAVSCVGHWFDIRRGYATGIACTAGGLGGAIFPLIILFAAPKIGFPWAIRIIALLSAILCTLACLLMKTRLPRNLKAGASIDFKALKDIKYASTTIAIFLVEFAVFIPITYIASYATHAGVNDTLAYAQIIFLNLGAVPGRFLPGLIADRLGRFNVMVLTSLICSVLTLALWLTAGNNIAAIVCYAVFFGFWSGAAISLTPVCISQVCATEDYGKRNGTTFTIVSVGALTGIPIAGAIQQRDGGEYQGLIVFGGVLYLAATVAFAVSRGICAGWSPKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Q8</accession>
    <name>A0A5N6U4Q8_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">RanGTP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_149390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Q8"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="654" mass="73735" checksum="DD9AA2A86F3B4DBC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4S3</accession>
    <name>A0A5N6U4S3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_127143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4S3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF867">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="196"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="354" mass="40159" checksum="96C38E5F51040B9A" modified="2020-04-22" version="1">MSKSPQSRNESSDDFEQVPVIDVSALSSRDPHRRQDLAAQIYYACTKVGFFYISNHGISQELLDSVHNAARRFFALPSEQKMEYYVGKSQKYRGFMPIYTEQMADMEIGDDTKNSSTGALLESFDIGYEIPLDPERTANDTLPPDTYSLYGENQWPIEEVLSGFRDIYTRYCAEALRLSRSLMRCFALALNLEEDYFDSMMKYPGVTSRMLHYPPQPVQGEIMLGLGAHMDYECFTILSQDNVPALQVQNMRGEWVLVPPIPGILVVNIGDCLSIWTNKIFRSTIHRVINLTGEERYSIPFFFGVDYDATVSVLPNCISEERPMCENPFKAGQFVRAQLAKSYVAYQGEGSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4U8</accession>
    <name>A0A5N6U4U8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_149908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4U8"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="600" mass="68094" checksum="B589F01FF6E9686A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5R8</accession>
    <name>A0A5N6U5R8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_148429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5R8"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="747" mass="81757" checksum="4CBF0E6DB93ABF5F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6S9</accession>
    <name>A0A5N6U6S9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_147995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6S9"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="108" mass="11527" checksum="B752589329B7CFEC" modified="2020-04-22" version="1" fragment="single">MSDHGNVVEIKSDAEFAEKVTNSKGVVVVDCYADWCGPCKAIAPKIAEYSTTYPGAKFYKVDVDELSSVAGELGVRAMPTFFFFKDGEKVNTVTGANPPAVEAGIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U781</accession>
    <name>A0A5N6U781_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_147719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U781"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000528">
        <property type="entry name" value="Nucleoside-diphosphate-sugar epimerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="304" mass="34027" checksum="1BF258F0E110A904" modified="2020-04-22" version="1">MTIALLITGSTGKQGGAVVDGLLAQDADVEILAVTRNPQSPSAKKLAQKSDKIKLVQGDLDHPAGIFESAKKASQLPVWGVFSVQTPFAKGESLESEERQGKALIDEAIKQHVQHFVYTSVDRGGDSSTDNPTNVPHFITKHHVEQHLFEKTRDGSMNWTVLRPVFFFENLTPDFMGKVSATSWDAYLEGKPLQCIATSDIGYIASIVLLQSDRFKNQCISLAGDELTFDQLAKRFKTQTGKSLPTTFHFLTYLLMMMAKDFRLMFKWFFRHGYGADIKQVKQIHPGVKNLETWLKEDSLFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7A4</accession>
    <name>A0A5N6U7A4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neutral protease 2</fullName>
            <ecNumber evidence="15">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_172115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="15"/>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7A4"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 15 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025075197" description="Neutral protease 2" evidence="15">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8154486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="37367" checksum="7FA41384D1010D12" modified="2020-04-22" version="1">MRVTALSTALFALASTAVAAPVTESSSPGLEVKLTQIDNTRVKAVVKNTGSEEVSFVHLNFFKDAAPVKKVAVYRGSDEVQFEGIKRRFRTSGITKDAVTSLGAGETLEDEFDIATTSDLANGGAVSIRSHGFVPIVVDGKVTGYIPYKSNDLTLDVDGGKAAKVTKVLSQPIRRTTVDSCQGSNKSALQKALSNAADLATQAADAAESGDASKFEEYFMTTDKGTRSTVAERLRAVAKEASSTSGGSTTYHCDDPYGYCEPNVLAYTLPSKNEIANCDIYYSELPALAQSCHAQDQATTTLHEFTHAPGVYRPGTDDLGYGYDAATQLSADDALNNADSYALYANAIELKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7F2</accession>
    <name>A0A5N6U7F2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:glutathione transferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF22">
        <property type="entry name" value="GST N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="258" mass="29904" checksum="09275ADACEA0A089" modified="2020-04-22" version="1">MSGQKQPDYHLIGTHTRYSGWTSRVETVLEYFNISYTAQIITLSEVKSVSHTGLVPLLECRSLDHDTPLNDSLATCEFLAESHPELGLWPRDRRLRALARSAAAEMHSGFTTLRTSYSTNFIARYTGNIPVSEQAKKEINRLFVIWDTARRVTKQRLAELGETDEGFLFGRFSIADAFFWPVLWRFRTYNLPLDGATQEVLAWMGTMWDDPTMRRLAHNYYRQAKNPATSIEHYDNIFPGRDDIHYGTFPEDWRFTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7F4</accession>
    <name>A0A5N6U7F4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_126445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7F4"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="641" mass="73181" checksum="E5A78AFC2CE9306D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7G3</accession>
    <name>A0A5N6U7G3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11 12">Catalase-peroxidase</fullName>
            <shortName evidence="11">CP</shortName>
            <ecNumber evidence="11 12">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">katG</name>
        <name evidence="14" type="ORF">BDV25DRAFT_147511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11 12">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="11 12"/>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7G3"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="131"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)" evidence="11">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8154577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="753" mass="83890" checksum="B285373FDE342874" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7L8</accession>
    <name>A0A5N6U7L8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_167808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7L8"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="33"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="37245" checksum="7AA46A0EF6D2010B" modified="2020-04-22" version="1">MRAPYSITPTDQSGAIVITATLFMSWMCMVSLFRLYMRLSMNGPLSLDDLAAFIGGLCQAFGVGHVGAMMYSVSHGLGRLTEQSYEEEQSAREALYAADLLFFAGHSAAKISVCLLLRRLGRAKRYLLMCNVTGLATCVWALASILGIAISVVDRVGSPIFANIGWKVLTAFDVVIEATLLGLSIFLVWGIHMPIKRKAAVIFAFSTRISIIVLAIIRQLYINQAFAAYNNPVYVADAVIMTEVLLHCSLIAATIPCLKPFVASFDTGWGQGTARKGQSSYVNSGSDSHSTALAPRCIGESQMAVPGSAQSYDSHSSRQLMLSRDDNWDADMIEMDLISRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U817</accession>
    <name>A0A5N6U817_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U817"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000101">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="303" mass="34389" checksum="E42D0834464D5734" modified="2020-04-22" version="1">MRSSTKLTLRILTHNIRYATSSPFKGERPWEERKQPLVNELLYTTRNQDAFICLQEVLHGQLVDIHSGLNENSALPSKPQDEVWAYIGVGRDDGREAGEYSAIFYRPTVWQLRHWETVWLSETPEVPSKSWDAASIRIVTVGVFTHQISRQTILAMNTHLDDQGSRSRFEAAHIILKKIEEYQNGEYGHVISGVFLTGDLNSEETQEAYSVLTGDDSSLVDTAKEVDQTKHYGNELTWTGFGYEKEDPSRIDYVLLGPRPVEVNDGGQPWTVEGYAVLANRFDDGMFNSDHRAVVVDVRLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U844</accession>
    <name>A0A5N6U844_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_147861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U844"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43728" checksum="597C45FEA0F910FF" modified="2020-04-22" version="1">MKLSNQYGKTPLELAVANGNQTIVSLLSGNTAKQHRKLTNNGGSHTKTASGRALPMIDPLELVTSELCSKCTNFTTWIRAEESHSYHPHLKSYQEICQSANAGCMLCAVLQDSILDQIGEGVTERASSNIAVTITLRTDAQKNQSHDLLLARVGRETVTCAELFVDKNMYQNGKYLLPWYHAVEASSGQIVTGDAVRAPLRFAQYICRHMKSRCTAGIWHADLVCGLLWRACSTDFTFMNKFGPPTWSWTSIKSPISYSFAQSSRPFDPDSPYVATFGNLLPDQPSMTDRQEQALLISAMSTSFSKLNVQDQYEFYFDRRESRSNKFQKYMCLLLGEHLAELYGAGRQIGIVVEVRGMSLDQPEYIRSGVFLGPTVTSDLSGWVRREFRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U867</accession>
    <name>A0A5N6U867_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U867"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="509" mass="56379" checksum="41333573F5727E0D" modified="2020-04-22" version="1">MPLWPAHVPTNHEPSSHPLNIFSIMFDDVLYDIHSDNDVGATDAHNWSMKMRWLVTVIVCSIAGLVSFAAAVDSAAISQIASEFHVSEEAESLATAMYLFGYGVGSMVSGPFSETLGRSLVYIISLLMFMISTAATGASNGLATQSVFRFFAGFFGASPMVCVGGSFSDFWTARQLNYVFPIFAISTFVGSALGPCVGAFLAEASPSWRWVDWITVIMAGAMLIVVVVFLPETFRPLLLKLKAREIQRYIRSGKHHDIPFQQVQKASFARQILETIYRPFVLIIREPIVILVALYLTIIFVILFTSLNGYAFIFGKTYGFTQSQTGLCFLAMLLGNCLVIPLVPVTYNLYCRDLRHFRYSDDYSDTSSTEDITMPPPENQLYSAMFGAPFIPLSLFSMAFTTSPDITPWAPILSSVPFGFGFTTVFISCYQYVMDSYGIWSASALASVNLARCLVTGVMMMVTIPLYTNLGVRWSLMLVGVLSTAMVPVPYAFYKWGYVLRRKSRNALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T4</accession>
    <name>A0A5N6U8T4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8155027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="27549" checksum="50AC6FFCE4FD81BF" modified="2020-04-22" version="1">MDVPGIALITGAGSGIGRACAQLFAKEGSTGLALIDLSQASLEATKASIHASVPNPPKITLYAVDITSEPAITTTITSAAQEFNRLDYIINAAGISIKHPGGVGHATTDSWNKVLSVNLTGTFFVLRAAAKIMLAQAPLSSAIDGRVLCRGSIVNFSSIQGYAGIAGSAAYTASKHGVIGLTRTASEDYAKDGIRVNAVCPGYTETPMTMDDPLVREAMRVRVAGAVPMGRMGRAEEIADAVVFLAGGRSSFVTGTTLCVDGGFLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDB3</accession>
    <name>A0A5N6TDB3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_101890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742606">
        <property type="protein sequence ID" value="KAE8144267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDB3"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000014">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="279"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="846"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112595" checksum="689457ADA37BD0DC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDM0</accession>
    <name>A0A5N6TDM0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_93019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742509">
        <property type="protein sequence ID" value="KAE8144473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDM0"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="265" mass="29319" checksum="4A96ABC6129B6979" modified="2020-04-22" version="1">MATDIPVHFFDITSTLPGPAKAWSVNTFKTRMVLNFKGIPYTQSYISYPDIAPLLALYGVTPQADTIQYTLPAIVHKPSVKSNPHGALMDSFAIATHLDQTFPSPPLFPSADASYALSLAVIKLLSNLMSKSYQLLIPKVADLLDPRGREYFIKTRSAMFGKPLSEVYPEEAEVRKITNAAKAELEPLAQMLRGRLGKKGPFFEGQKPGYADILVISFMAWVEISNKALFQELIGVGEGELKALWDACLPWVEGQGETKEWDIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEH5</accession>
    <name>A0A5N6TEH5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_145350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742450">
        <property type="protein sequence ID" value="KAE8144706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEH5"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000457">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="215"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="465" mass="52699" checksum="FC0C5294667D8281" modified="2020-04-22" version="1">MAPQHSNDVLAPLLGALNLQTQRPKYPFVFLPEQMPQIPQMPQMPYMYPNVLPYPTLPYLMNCNEEQKTENFNLPFQMMKTPNGYILQDLESLTQQDPAIPRAVPAMWTNPSELTLAKCLENREGITNVYIRGFLPETTDEMLYAYASRFGKIDRCKAIVDLDTGLCKGFGFVQYYNFESCENCIRGFFYLGYQASFAQKSRNSRLKDLEDKTSTNIYCTNIPNDWTEADLRRHFEPYRVVSEKISRDEKTGVSKEVGFARFETRDVAEKVLNEYHNITGKDGVKLLLRFADTKAQKLLKQQSNERRAYRAGEYNYSVEVVQGSTPSPSLHRLQQTASHLSPGSQISYSSPIPMGSTWTPATSISPSYPVVKNQPSNMHLNTWSAGNSPATMDHTPHYRGRLPVNRKAWNDTISRGSSRTALPSTPCADPRSGTSSPRKENIKAESLSPIPSRREIIVKSPRSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF45</accession>
    <name>A0A5N6TF45_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_145189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742422">
        <property type="protein sequence ID" value="KAE8144870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF45"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40031" checksum="D4E20F1BF081CFAE" modified="2020-04-22" version="1">MADPLENAYETVNSLPSVSEKTYPIAGILVTVFGLEELPSHVSEVACLWLLHPRLATKERMSGFATAAITDWNIRAKTDSHDDSNLSAKGLIAIAFDQRNHGTRLVEPLANEAWRQGNPRHAQDMFSIFQGTARDVSLLLDYLPSYVFPDSGRRVCKNLVLGVSLGGHAAWSCILHEPRVSAGVVIIGCPDYVNLMMDRARLSKHTTWMNSDPPGSQFLGSEAFPTPLLSAIRKYDPASLVFNHLHADSGIGPSCKDPLPEPTEQEKQALRPTLTRCLAGKKILNLSGGSDRLVPYHCGESFLTWLKKASAPDGWFADGAMTLEDVIVEGAAHQVTPKMVSEAVRFISDTLSHGDSREAGTDRGSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFB1</accession>
    <name>A0A5N6TFB1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_166026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="ML742432">
        <property type="protein sequence ID" value="KAE8144809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFB1"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000016">
        <property type="entry name" value="phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
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            <dbReference type="PROSITE" id="PS50975"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144809.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="572" mass="62280" checksum="70995133B031B159" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFS9</accession>
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        <submittedName>
            <fullName evidence="3">Spt20 family-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">BDV25DRAFT_165129</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <end position="305"/>
        </location>
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    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="813"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145224.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="938" mass="103729" checksum="20A089FFDDF63297" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">BDV25DRAFT_164932</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
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                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
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                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FR47"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="263"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="405" mass="44133" checksum="A60461DF622D1399" modified="2020-04-22" version="1">MKLKHHISFSNLNSPMDPEKPYLEPCIHDYDPQALITLLKSHLPHSVPLLRRLQHGLAYPSSTSRILTTFSGADAPVSPWLAAHVDLFTGGETQIVIYSSLEAQTTSPFTERDGVSTLLAPPEILGQARAQLLTLLSHIKAELLPVYLSSIQPVGPTPNSSSPVLNPASSQPGLIPPPPGAFFIGNLHTGLFSLLKASGEYSHPDPVPGLRIHRFNNPPYVKYLFRGHQFVSPGSASAPLPAGYRFTDKTGRLGVQSHHLDLIRSRTSIPRSRETLNKLPGAPIYSDRETQPHPSDSSGAADNPHDRSAVGEMPIAWAFLGVDGSLATLHVEPEYRGQGLAMAVAQEAMRLGMAEGGIWRDHGEEGEVWVHTNALESNIASRRVMEKLGAEPAWTCTWTVLEWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG25</accession>
    <name>A0A5N6TG25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_144816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742366">
        <property type="protein sequence ID" value="KAE8145257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG25"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26960" checksum="4CF0D4F67E344ED4" modified="2020-04-22" version="1">MASLYSSSLRQRRFAPLSAEGRESSNAPLLKGIVFDVDGTLCLPQNYMFGQMREALGIDKKVDILHHISRLPTPEAQLEAADKIKAIEREAMRHQEPQPGLVELMDYLQERQIKRALCTRNFETPVRHLLGNHLPAHVFLPIITRETPGLLPKPDPAGILHIANEWGLQNQGENLIMVGDSIDDMTAGHTAGAATVLLLNDHNGHLKEHGHTDLCIERLDELIGILDGGFVGHREGDKAPTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGA4</accession>
    <name>A0A5N6TGA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742367">
        <property type="protein sequence ID" value="KAE8145250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGA4"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="328"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="60133" checksum="95C5214B8EE60A92" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGF0</accession>
    <name>A0A5N6TGF0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_144705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742351">
        <property type="protein sequence ID" value="KAE8145387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGF0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024854411" evidence="2">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="348" mass="34339" checksum="32A0CB4BEFB978E5" modified="2020-04-22" version="1" fragment="single">MKLSIVLLTTAILGTVALPPNIPRNRGTIVVRNIVEASNSAPEAGHSSTDQHDSGKHSSTSSKSKGHDNTSKPQGHDSTSKPTGQDSTTTKGQSNTSSVNTAATSTSTGESNGSDSSQSPSGSESTSTSSSTTMATTSSSSTTTTNTAEDPATTSSTISNTSTSTTAEDPATTTADDGHTSNPSLDASGNQATPSSTSTNTSEEPAATSTSGSTTSTSNTAEDPAATTSSSTTATNTADDPATTTSSSSTTSDDGHTSNPSLDPSGNQAAPTSTSTATTVVTSTATSSITSFTTSTGTSTTTSTATTTITATETSTTTSSVTDTVTDTVTDTVTDTVTDTVTDTVTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGH0</accession>
    <name>A0A5N6TGH0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_165223</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="ML742375">
        <property type="protein sequence ID" value="KAE8145191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGH0"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="954"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8145191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114538" checksum="859F4A00A0ECFCFB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGP6</accession>
    <name>A0A5N6TGP6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742366">
        <property type="protein sequence ID" value="KAE8145261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGP6"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="543" mass="61653" checksum="B3AD32D83138ACB5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH22</accession>
    <name>A0A5N6TH22_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_66513</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="ML742327">
        <property type="protein sequence ID" value="KAE8145626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH22"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8145626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="553" mass="64156" checksum="061B5F3F27EB98B1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH73</accession>
    <name>A0A5N6TH73_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742318">
        <property type="protein sequence ID" value="KAE8145724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH73"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="113"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="218"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="33812" checksum="88EA72E905D3F924" modified="2020-04-22" version="1">MSSTTAEVVPAGPKLEKKPVKFSNLLLGAGLNMFEVTTLGQPLEVIKTTMAANRGDSFPGAMGRIWGRGGILGYYQGLIPWAWIEASTKGAVLLFVASEAEFSAKVLGAPDFLAGILGGMTGGVAQAYATMGFCTCMKTVEITKHKMAAQGVKPPSTFATFMDIYRKEGIRGINRGVNAVAIRQTTNWGSRFGLSRLAETAIRRTTGKDEGQKLSAWEKVLASGLGGGLSAWNQPIEVIRVEMQSKKDDPNRPKNLTVGKTFKYIYDSNGIKGLYRGVTPRVGLGIWQTVCMVALGDMAKEAVEKLTGEKVTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THE9</accession>
    <name>A0A5N6THE9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742311">
        <property type="protein sequence ID" value="KAE8145804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THE9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="84" mass="9567" checksum="7BBE0C5368877C7A" modified="2020-04-22" version="1">MPISSSAGDRVMSARHHPETSALTSLEFTFTGLCISLPLYILWELPIVLSHICIRQVAVRLYPHRIIFYQQDQKCVQARLISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THI7</accession>
    <name>A0A5N6THI7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742308">
        <property type="protein sequence ID" value="KAE8145844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THI7"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000431">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="38793" checksum="4B47310415350A94" modified="2020-04-22" version="1">MASAGASVTQLASKLYEHCLNNFPLDQLFYQQDLLGLGIVPKSDIALLLKCTQSLVDQKLFRLLQGKNERLAWKIISREDAEKLQNLSPDESLVYNVIHSTGRSGIWVRAIGNRTGLHKSILDRCLKSLEGKNYIKSVHNVKFPSRKMYMLAGLAPSEDVTGGAWFTDGVLDENFINTVAGYIEYTVSRKSWFEVPSADAQRNKRIKTSDGSAAVKQEPGQKSYIPFPAGFRGYPTVAMLTGAVNESGITPVRLGEESIVQLLDMLCYDNKLVALNNGEMYRSVKNPEAVKQSQSRKSAGEDTGIDDRLVTNGMTEAPCGHCPVFKLCAPGGAVSPENCEYFDPWLEKALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THL2</accession>
    <name>A0A5N6THL2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_163796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742311">
        <property type="protein sequence ID" value="KAE8145807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THL2"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1050" mass="118134" checksum="A4F86F17DE100B0A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THR0</accession>
    <name>A0A5N6THR0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Utp14 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_60708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742258">
        <property type="protein sequence ID" value="KAE8146508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJG4"/>
    <dbReference type="OrthoDB" id="4812032at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="273" mass="30784" checksum="9BAFA20A7EC3D24B" modified="2020-04-22" version="1">MERQLPTRDLPIKRRSTSPQDNEDSKRPREAALDLLALRSLSESLKILPVPEDTDDLETTARKIEDLAQVVEDGNSLALWTGLKLASMRDPETLAEAQMTLSELELYEEWKRMRNPRIDGVDNDDTASRDTTTTTMKLPEFNWDENKAPVPSGAQSVKKFTQRAAAMDVVWGHQGATAEHAAWLTFNMVHILPLIKAITKLSNIQKHIKETDPLAGKLTNTEAAELETARKVIAITEGIKTREMGKIRKQIRSIHESAAALKSRMQALERRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJV1</accession>
    <name>A0A5N6TJV1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_143559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJV1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="583" mass="65001" checksum="49EE4ECCD21191B6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJX6</accession>
    <name>A0A5N6TJX6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative glycogen synthase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_143726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742264">
        <property type="protein sequence ID" value="KAE8146409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJX6"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="407" mass="46599" checksum="7CB7404D662A8A8C" modified="2020-04-22" version="1">MSQNRPGVFSSLRMGGELADVDITCCYAEVVREKVQDGLTGETKEISYSQCKIVGNGSFGVVFQTKMMPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPNTGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKAPHEAIDLISALLEYTPTQRLSAIEAMGHPFFDELRDPNTRLPDSRHPNGPSRELPNLFDFSRHELSIAPTMNSRLVPPHTRPALEARGIDIDNFKPLTKDEMMARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK70</accession>
    <name>A0A5N6TK70_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_46169</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742244">
        <property type="protein sequence ID" value="KAE8146756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK70"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000154">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003387">
        <property type="entry name" value="PRK04531.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="354"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8146756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="905" mass="98896" checksum="B9746469B59B65D1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL34</accession>
    <name>A0A5N6TL34_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL34"/>
    <dbReference type="OrthoDB" id="3485856at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="41274" checksum="5C5722073154FE52" modified="2020-04-22" version="1" fragment="single">MAAGLTPPGSVLEPPLTPSSTDEKPLSTSARSVVNLLQLHLQGHRLQPWWERRLEPDDYTEVLRVLDADESLRNYVEDKIRYDYDPCRHCLAIRRPSPLHDILCAKIVDEISRQLSQFQQIDGPVADFTKEVEHFATSRILIPEDTEDGRQIYSRREPDASFGHRQAHYPGVIVEVCYSQKRRRVAHLADEYILNTDGSVNAVLAFDIDYRDSKRATVTVWRPDYVTVDGVEGFQAIAVVDAQPFRTDSGLPVDGCRLQLSLRDFATEYLCRGRSDLKREIVLTSEQLCCFLSSAEARQDSQTQIQGSVNLVRPGVLKRRRPQTPPEQASSEDEGSVGRERDSKRGRQSSDYRPCSSSEGSKSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL37</accession>
    <name>A0A5N6TL37_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="1">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_143091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="1"/>
    <dbReference type="EMBL" id="ML742227">
        <property type="protein sequence ID" value="KAE8147067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL37"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000025">
        <property type="entry name" value="NADP(+)-dependent glycerol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="325" mass="36859" checksum="AACF10D9CC3079E6" modified="2020-04-22" version="1">MSSGKVFKLSNGVTIPGVGFGTFASEGSKGETYKAVQKALQVGYRHLDCAWFYQNEGEVGDALQDFLKENPSVKREDIFICTKVWNHLHRYEDVLWSIEDSLKKLKTDYIDLFLVHWPIAVEKDGQEKPKIGPDGKYIVLKDLTDDPKPTWDAMEKLYADKKARSIGVSNWTIKGFEKLLKHAKVAPHVNQIEIHPFLPNEELVQYCFKHNILPEAYAPLGSQNQVLTTGERVSENKTLNEVAQKSGHSLAQVLIAWGLRRGYAVLPKSSNPARIESNFQITELSDEQYEAINKVAEGRHFRFVNMKDTFGYDVWPEESAKNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL72</accession>
    <name>A0A5N6TL72_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_161140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742226">
        <property type="protein sequence ID" value="KAE8147102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL72"/>
    <dbReference type="OrthoDB" id="4392610at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="133" mass="15724" checksum="EFF5489CE61625D5" modified="2020-04-22" version="1">MTSVDHNAIIHAYRHLYRQGLKVVNYSTPSRYVLLRTLRSSFRSFAHRDFDPQKISNTMYFLQRATDVAGLEHRIVKNLLMVRYWEQPQVRKELRQLKGLGIDQRHLPLRKDAIKQFNLTLMLLNESLGTCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLM9</accession>
    <name>A0A5N6TLM9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_36219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLM9"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="166" mass="18980" checksum="5C8EDA41C91D55A3" modified="2020-04-22" version="1">MKDIELNISDIHSLGRDQAFEILNQISRVEKKTFPANEAFSFCEELWRKKPNTKVLYATSAASDIRSPLVAYAVYVRQKGIALLHKICVAESYRQQGAGKQLMSYIKQRLQREGCQCIQLWVDKARIAARGLYIKFGFEEREEIANYYAPGRTGIKMILNIDNGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLN3</accession>
    <name>A0A5N6TLN3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLN3"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="171" mass="19479" checksum="051FA798AD07F42B" modified="2020-04-22" version="1">MSDQLTKVDSAIAGLSISPKDEKKNHKRNSSQTDGVWNIKDLEEKRIELVLPIETQKTGWKLNTSPSTIEDKDILKLHLVNPPVKKIDLKFPLGLEVHARNLKGVTIKDALDAIYKQFKKKADDELDKPYLAGFEWDKDESWTRLIVHQTKTPPPQQQSSNKKSKKKKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLW5</accession>
    <name>A0A5N6TLW5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase dimerization-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_160574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLW5"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF21">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="192"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="284" mass="30311" checksum="5ABA634DDB10F3AC" modified="2020-04-22" version="1">MPTLAFIGCGNMGSAILSGLLDATRQSPTTAKITDFIVNTKTAESATALRTTYQADASRVTVTNGQNVRAMQEADIIMLGCKPFLAEGILSEPGVAGALAGKFVISVMGGKTPAQILEFILQGAETRELEKPVITRAIPNVAARLRKSMTIVERNSELSEDRAEILAWVFEQIGKVKFLEPEQVDVGSMLMATAALMCVPVDGILDGCVIEGLRRPEALEMTAQCLEGMAGLLREGVHPAVLRESVSSPRGCTIQGLHTLEKQGVRGTFADAIVNGTKHFRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN30</accession>
    <name>A0A5N6TN30_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_159719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742193">
        <property type="protein sequence ID" value="KAE8147734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN30"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024956511" evidence="2">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="270" mass="28763" checksum="F55A8C1CCFA5BDF5" modified="2020-04-22" version="1">MYFTNKSLLLFLGSQILAANAAPVSTATSGTEPSGIAQYSNYGNYGQYGSYGSYKRDAPEAEAEDAKSTATTTATATGTPAQYANYSNYGKYGSYGAYKRDDAEVADSVTTTTTVSATATPVQYGNYGNYGQYGNYGSYKRDEVPEDEDSKATTTITATATATPVQYGNYGNYGQYGNYGSYKRDEVQEDEESKATTTSTATATATATPVQYGNYGNYGQYGNYGSYKRDDVPEDAANESATTSTATATATPVQYGNYGNYGQYGNYGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNF1</accession>
    <name>A0A5N6TNF1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742186">
        <property type="protein sequence ID" value="KAE8147886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNF1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="55" mass="6280" checksum="554A157D4B5B4E4C" modified="2020-04-22" version="1" fragment="single">KKNGEVGAGQASVSPEQSRSSLSACRWIHEPRVRRAERMRVTPMTEFHEDKLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNL8</accession>
    <name>A0A5N6TNL8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_159378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742186">
        <property type="protein sequence ID" value="KAE8147877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNL8"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF694">
        <property type="entry name" value="AMINO ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="472" mass="51165" checksum="DF4B2985358989F1" modified="2020-04-22" version="1">MSTPLEEVKDFKITQGLPTNDDIAIANADELKPENDSFEVFKKGDGQVDFRTVSWLRASAIFLKMLFATGILSIPSVMYDLGAFPGAVNLVGWCAINAYGAIILGNFRNAYPQCHSVADMAQLIGGPVLREIVGFIFIVTYVITAASGIIGVSAAFNALSLHAFCTVWWSFIATAIIAACASVRKFAHIGWLTWVGFFSVLIAVFIIVIGVTTRDRPAVAPQTGDFDLGYRVIGQPTFAAGITAAATIFVSSAATSAFLPVISEMRKPKDYPKAVYLSMGFVTASYLAFSLVIYRWCGKWIASPALGSAGETIKRVSYGIALPGLIVSGSLYVHVAAKYLFVRLLRHSRHLQANTPTHWATWLGCTTILSSISFILACAIPIFTYVLALVGSICFAPLSISLPGWLWLYRHGHYWKKDAVRSTIYILHVLLVILGLFMTIGGTYGVIVQIMDAYNSGKIDKVFSCADNSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNR7</accession>
    <name>A0A5N6TNR7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_159230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742182">
        <property type="protein sequence ID" value="KAE8147964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNR7"/>
    <dbReference type="OrthoDB" id="5376312at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="47302" checksum="A0B2AF21778659A2" modified="2020-04-22" version="1">MYIPDHGQLIRRNETTSDSDKASKSDTTHRNNIFIICAACIVFALALILMTYFSMRALRRMDCSPKYIPGKFLKDKWNRWQVGATYGQVPDASSSNRNGGETDSRPREDGAEMNTNSAVRRETSVRSVMTLPPYSSSPKPTEQVIAREGERGGMDVVVEFPETAEEEETRREDLMEALYQVRQQRRQEIAEREARRQERREARARGDYIRLEQLRMEGRNRAQSHSSANGSAPNLASAVNLAEQQSRGRDRRISSVSYAALGYVRHDGTRMRTRSPDADSSPLLSNAAAVSSDTPGRSSTSSLTHVHSRGESYSSFQSGTTGGSDQDALLPVQSRPTSTHAPAPSADGGDVGDLTIPPPNYDNLDWGEAPPYESPIAERATPHLLTPLPTIHIDLASPVSNTPTPTTPTVPHRDDTNSPENRDTHRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP14</accession>
    <name>A0A5N6TP14_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="ML742179">
        <property type="protein sequence ID" value="KAE8148017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP14"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969029" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="467" mass="50239" checksum="B6F9BC50DCD820DB" modified="2020-04-22" version="1">MMQPTSALLLVASLLAALPANADGLYTKKSPVIQVTQKNYDQLIANSNHTSIVEFYAPWCGHCQNLKPAYEKAAKNLDGLAKVAAVNCDDDANKPLCGRMGVQGFPTLKIMTPSKKPGKPRVEDYRGDRSAKAIVGAVVDRIPNHVKKVTDKNLEEWLSQDEESPKAILFTEKGTTSALIRALAIDFLGSVKVAQIRNKETEAVEKFGVTDFPALVLLPGGEKEHVVYDGELKKQPIIEFLSQVAAPNPDPAPAKPKDKSTKSSKSTTAGSRSSTVIDDQAENLKPTESPDPKVEDAPESKPAQVPIPAPPIDTLPTVEALEAACLQPKSGTCVLALLPEPSEPDADLPSPAKEAIVSLSEIAHKHAVRKSHLFPFYTVPAINSGAQTLRNGLGLAEGAQTVEIIALNGRRGWWRQYDPSDVADYSVTRVESWIDAIRLGEGSKAKLPDGIVVEAEPEKPAADHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPM5</accession>
    <name>A0A5N6TPM5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_168556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742167">
        <property type="protein sequence ID" value="KAE8148265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPM5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="90"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="426" mass="48897" checksum="CE5BF71A76EACE4A" modified="2020-04-22" version="1">MHRLSFNTFVRASRYSTLSLRHLTSPRLSFSFVSQRRTIATTHMSQPRRFPSSGFHLLDSSTTIEEETLPDYLEERYYPVHIGEVFQSQYQVVTKLGFGSSSTVWLCRDLCNERYLILKVHVRTRRPLAEVGITKHLQAVHGTHGGEKYVRLTLDAFEISGPHGMHPCVLYEPAGIDIRDYTRCLEGDALPESLLRPALRLVLIALDYLHQGSVIHTDVQPNNILLGIDDMSILAEMEEDEVSNPSPRKQISDRTIYATRAMPLTSGEPMLADLGEARLASGKQTGLIMPSIYRAPEVSLNMNWDNKVDIWGLGQMQGHLFRGQSLENEMEHAQRFAEMISLLGPPPVEFLERSKESLKFWDENGNWKYNSIEVPEQSLEGRESRLEADDKRLFLQFIRKTLRWLPEERPTAKELLLDEWLRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPQ5</accession>
    <name>A0A5N6TPQ5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_22899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8148111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="374" mass="41362" checksum="3A13A98F447FAE2E" modified="2020-04-22" version="1">MNTVTNTTNTSTQEVQRGGSRSSSSLMTDSSEEERKPIPSPDLLPPRLLVCNPKPVYGPIEPLPAHLEAILEEWHRKPGNGGKAPPCKVQKTPNTRWRTFDRQGNLLGLSLFEVQKPARYHVLVLRPAEGPEKLVSSYFSFGTQYGIYLVAWRGVGAGFEGACCAVRKSAKGDDRDSYQPEAWTALDTLVKRRKGAAAQTETEQPVPQSARLRRMHAAAQEPPAPPAEVQEEGEEESSEEESGEESTSEEEEEEEEPLPSPVVKRRRIEEPSAPAGKAPKVVFKLVSYKTAAIRCFPLEECKSGKDLFDKARQFFQLFDKNLDVKILSCQIASQRAQQYVFEGSEGEFNLLVEQAVGVKDGDTVIVDVGHVQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPQ9</accession>
    <name>A0A5N6TPQ9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_20059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742166">
        <property type="protein sequence ID" value="KAE8148305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPQ9"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF100">
        <property type="entry name" value="SAM BINDING MOTIF CONTAINING PROTEIN (AFU_ORTHOLOGUE AFUA_4G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="399" mass="44555" checksum="581445C31EB274A6" modified="2020-04-22" version="1">MDMMSVGTAAFAPAAASGSDLHSLISSTGPTRAATSTSSLNSLNDYTNFPLIRQGDRTYLRDPENLYPLPCDLPEIHRQTLRSLMLVRVFGGPFCNPYFADRPPVRVLEIACGSGLWSSLSHDFFARRGARNVAFHGIDLVSVAPDLRKKGVNWQFKRHDLRKARFPFPDDYFDFVFIKDAGMCPSSPAQQASGLSEPLRVLKPGGVLEVWDSDCVFRSLLPNPAPARKLASREQEVADATATYTFSSATPFTKVQNKFLQDYNSWVEKAFDHRKLTALPCATIGLSFNSEVDVLEKVDSRRIAIPLGDLRWERESKDMSGTRKQLTADQMSIRRTALLTVIQMIEGMEPILMEASGKSRDEWDRWWTAMMADVFQKGGLANGECLEVSAWWGQKKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQN3</accession>
    <name>A0A5N6TQN3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_168353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742154">
        <property type="protein sequence ID" value="KAE8148597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004222">
        <property type="entry name" value="Os02g0288700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="306"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="626"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="972"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1289"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="854"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8148597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1537" mass="171581" checksum="870B89759EC57E6A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQR1</accession>
    <name>A0A5N6TQR1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_157825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8148693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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            <end position="61"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="615"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="715" mass="80533" checksum="2FC297D26A43D2FE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQY0</accession>
    <name>A0A5N6TQY0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_131142</name>
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    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
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    <dbReference type="EMBL" id="ML742156">
        <property type="protein sequence ID" value="KAE8148541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
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        <property type="entry name" value="ENTH_VHS"/>
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    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
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        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="794"/>
            <end position="1037"/>
        </location>
    </feature>
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        <location>
            <begin position="249"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="296"/>
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    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117775" checksum="544E65AA1CDE01EE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQY5</accession>
    <name>A0A5N6TQY5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_158132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742138">
        <property type="protein sequence ID" value="KAE8149010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRT7"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="15">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8149010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="827" mass="90136" checksum="F7453E7CDD69848B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRU6</accession>
    <name>A0A5N6TRU6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_168075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRU6"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="256"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="450" mass="47156" checksum="07FB120AE0DD3619" modified="2020-04-22" version="1">MSNTKGISTGVELQQSGQIGDRLNKSPGEDTATPPDPDEVIQASLLADAEVPDGGYGWIVIFGCAVFTWWFIGTAYCWGILQAALVKNGVSSSSTLSFVGSLAPACISFLGILNANIIRKIGTRISALLGIFLLGLGEVLSGFVTSNIGGLFATAGVVMGIGISLCFMVVSAVPAQYFKTKRGIANGIVYAAGGLGGAITSFIMNALIDKVGIAWTFRIIGFMTWGTGLPTAWLIKQRVPIRRTAFVEWRLFRDIRFTLLFAAGAIATFPLLVPPFFLPLYTESLGMSSSAGAGVVAAFNFASAMGRLLCGFCSDYVGPLNTLFVSLLLSALSMLILWPVSTSLGPLIVFVIINGMANGGFFSTIPTVVGNVFGSARVSVAMGMIVTGWAGGYLLGAPIAGYILNASGGEDGGVVAYRPAIFYAGGMAMSATIMAMFIRLKTDTRPLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS45</accession>
    <name>A0A5N6TS45_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_141057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742132">
        <property type="protein sequence ID" value="KAE8149165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS45"/>
    <dbReference type="OrthoDB" id="5369299at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="36736" checksum="D83E5972D41B4973" modified="2020-04-22" version="1">MWTVVLSKIPSLLARSGLGDGESVSVSPIINCVEGAVIAVQVWKTAGMRAQIENVSGKIVDLADGDIIPVVLGMRRAFQGYCGDIPDTLNNGDTVSCISKSGIVGVNVSVSGGKDDPVPMAVLGSIQKDGAAMNIKHYSIPRQQSLHHSAPIFAVAGSATNTGKTTTAVKLISHFKAKGLRVGAAKLAGAAFMGELRSLITAGAAPVMSFADGGLPTTCIDPKEVVEVAMGVLNQVNQAGVDVIVVEIGTSLLGFYNVLPILDSQDFKKHLAALFITATDPVSAWGGKRMMEEHGHHVALITGPVVNNASFLRFVETTLGLPAESNVGDMSKLFRLADSILERITLNLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS84</accession>
    <name>A0A5N6TS84_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_156781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS84"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="86384" checksum="67F2C889C66FF1EB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSF1</accession>
    <name>A0A5N6TSF1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_4274</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
    <dbReference type="EMBL" id="ML742128">
        <property type="protein sequence ID" value="KAE8149293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSF1"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000456">
        <property type="entry name" value="3-ketodihydrosphingosine reductase tsc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8149293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="366" mass="39993" checksum="70D3D214F6015CF0" modified="2020-04-22" version="1">MHQTLSLITSDLSPTKLGFSVLFCSFLLYTVGKMFGFGSRNEFVVEGRTVVITGGSDGMGKAVACQLAAKGANVVIVARTVKKLQEALDDVKASAANLNRQRFHYISADLKDAAQCEQIINEVTEWNDGLPPDVAWCCAGYCNPGFFIDTSVETLRDQMDTVYWTAANTAHATLRKWLVPVSPAEQKPMPRRHLIFTCSTLAFVSVAGYGPYSPAKAAIRSLSDTLNQEVEIYNGARVSGHAAPAADIKIHTVFPMGILSPGFDNEQKMKPELTKQLEAADKPQTTREVASTSIAALERGEYLITTMFVGHIMKGSAMGVSPRNSLIRDTLTSWLSSLAFLHVIPDLRRQAWNWGVKNGLPFTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSK0</accession>
    <name>A0A5N6TSK0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSK0"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="273" mass="29963" checksum="8D0ADEADC2D90105" modified="2020-04-22" version="1">MLIGTLSMIEGPHGQPSNAGNATYITSSLRTTINHLRTHVGNSFCLRGFALVLIHDIARDTILQALLPINGNSTLKRNTRYLISVVVLANLQVLWVHIVITRPSPKFLYQRLPSLNCWVRAIPIALLESILCRLAVPITLLIELHLIQAVGKIDIDQNLDTNNQAGGHAYALAAVAPTLIKFWLALPARVILVRIAASMVPDDDEPIVKLDARLKGGGAPLGMFGAWRKDSWARACKIQTRGLIAGTAIFLLGQLVLPDFQSYVPFVPMWFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSV5</accession>
    <name>A0A5N6TSV5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BDV25DRAFT_156366</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSV5"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAE8149442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="370" mass="42180" checksum="191DFE7BA72E1BCA" modified="2020-04-22" version="1">MPGRVLPTFTSAEVASHNDAKSCYVTVGSKVYDITSFVDDHPGGGDLILEYGGKDVKEILRDPVSHEHSEAAYEILEESHIGFVVNAKTAGVENGEGQGSTPVYASTGMSREEDLSVETDYTNDFKTHKFLDLNKPLLMQLWNSGFSKEFYLEQIHRPRHYRGGESAPLFGNFLEPLSKTAWYVVPILWLPPVTYGTMLGFAGLGNVPAAASYWAGGLFLWTLIEYIMHRFLFHIDKFLPDNRVGLTLHFLLHGIHHYLPMDKYRLVMPPTLFIVLATPFWKLAHAVFFYNWYAALTVFCGGVFGYICYDLTHYFLHHRNLPTYYKQLKKYHLQHHFADFDNGFGVTSRFWDRVFGTELETPAPKSVKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSX1</accession>
    <name>A0A5N6TSX1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_130338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSX1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="28450" checksum="1D2D09753675196B" modified="2020-04-22" version="1">MPDQTTKPPPSLDPSNYPNGKKSLAGISLRAFIIGTTLGLSVSGTISLLFLDTPLWRLPFFLASLCLFHFLEYYTTAAYNTRYASISAFLLSSNGWAYNVAHISAALECVLAWSLWPSASYLSWGALVPGFKIQVALGLVLIVVGQTVRTLAMVQAGSNFNHTVQVERKEDHNLVTHGVYSIFRHPSYFGFFWWGLGTQLVLGNVVCFAGYAVVLWKFFNSRIYREERFLVAFFGDDYVEYKKRSWVGIPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT70</accession>
    <name>A0A5N6TT70_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_156075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT70"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8149565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="794" mass="90606" checksum="256EF53A68B33B3E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTF4</accession>
    <name>A0A5N6TTF4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mannose-6-phosphate receptor binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_124432</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742117">
        <property type="protein sequence ID" value="KAE8149642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTF4"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025065024" evidence="10">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="319" mass="34994" checksum="942090C8B54A152E" modified="2020-04-22" version="1">MKSLATSLLGLLFFLSSPHTSVHAASDSSGSDALSPCVARSPTTGFYYDLNTISLSPPSTKDEKLRGNIRDESWHAKGHDYNANFTINVCAPVVEDIKDVVGVESARWKNVSAYYEKEGKIYSIGQQASQPFFRGRKLVLNYTDGSPCAGDFIGNGSRTKSTIMSFLCDRDAPTYQATPSFVGTMDHCTYFFEVRSSAACGAVAPADNQGLGPAGVFGVIALIAVVAYLVGGCAYQRTVMHQRGWRQCPNYSLWAGMFDFVKDMFTIIFSSLSRACRCRRPNHNQRNGLIGAIGGRRNTGRDIDAENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTQ9</accession>
    <name>A0A5N6TTQ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_123100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTQ9"/>
    <dbReference type="OrthoDB" id="5272500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="303" mass="35061" checksum="EBC7104A1C6F4F3D" modified="2020-04-22" version="1">MSTSGIVSPFRLSRRDQEKLARNEAFGAVREHLKRQEMGMNAPSFCSFHRHSCSDQEQESFRLHRDIVHTVLLPLFLLHHQASRVAARALPTHKAAESERAFRGEARSAYAWLHCILSEEHDWYLTERCPACIVLHVLHSEPTIRFVAVACLLSDHLQGLDLLHDNGRLPSFDFWLEALEMAVRDDPFWGEDFWPDIEYRACALTDGVKQLVLQCLELKSALERQSYQSQSYDPSAYFRRESSRQQSHPSMKLSSSASRMTGEEQKILSKVAANRCMQSYLQDRPQRFHVRRHADPRRRSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU18</accession>
    <name>A0A5N6TU18_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_122114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU18"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37674" checksum="B5D5D748684CAFB7" modified="2020-04-22" version="1">MSRDCIVSPYSVGSRHRICSHHPPPPVALNQPGRNLLNLDYDDPQVISQTCVRNPPVAGVDGTDRIVVQITESINVGLCKRAQVVTARVLDAGSLTSFTTDQVPIAKFYDPYYESFNDQPFLGVDINYTHECAAYTRLADLQGSFIPVFFGSFTLRLPVGDQCRIVRLILVEKISGSSMDRLDISRYSRFLRQRYLKEIIDAESALYTKDICHRDLCPCNVMFTIPRQRNRPVVIIDFGFVDFGRSRKPSDPEIENAWFPGVPISPLLRWQERYSRRTSFTSWIDWEWQPWLEAQCEHTRDSITDAQRERWQPLPQKDHISPPSSCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU66</accession>
    <name>A0A5N6TU66_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+ regulator and membrane fusion protein Fig1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU66"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="286" mass="31709" checksum="CC3E1AE1977F4BEF" modified="2020-04-22" version="1">MNISKKPFFKISSHHILMVICLISIIILSVLVSGCSSTEMSNIYLISMEYNNITNPVRGEPVVINHAIAEHIYNISENRHETIRGVLTGYRGFCVIQRDGAHVCSTRAATLAKTINGRNSRLRNTTVDPLNLIWMSQNFQDKMAFDGFVFMSIILMVICIVLFAGFPGWRKEIDSSGEEKEVKPYPSRWLMYSALVCSGLSSTMGLVVMQSQYNSVVAAGVMAEQLMYGAIQTHVGAAGMALGWVAVMCMGVVAIAAFGYVVKHQALSLIRKMLDKKDEEQDKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUG6</accession>
    <name>A0A5N6TUG6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_155763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742114">
        <property type="protein sequence ID" value="KAE8149721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUG6"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="48711" checksum="2F8C3EEB6C034189" modified="2020-04-22" version="1">MSPIVQLVLHVKRARAAINRGRRKSESMRQNLFSSSTSSTPELDRLNPVPTSSLWDILPVELQIKIFAHCGITDLFPLKLVCKSFYKLLSTHEHAITRQYLRQRRHGTLPSPIDSERTYTRHPEDDVVLLSDLFPPAKSAKGGHIYTFRYVYSLRRRQKLCSKLCYYIADRVMDRFAYTEMGFMKTMFPSKNERLEFMKRATARIWFYLTPLMYYTLYFLESYTLARREQTNMLLQDFEAGRLPVPIPPDVRKSMYRDLQVKIIQSPPFTNTATLIATHHCMQLLVSYLKYTVPPDEPGPTDDSWISSLLTVSPFTRIVQYFSAEIGDGGNQRVQRKDFMHNFHSDITVNEKDDMNSLVFESAPNAHLHSSIQDVWFDVARRELASRQATQHRAESILIRDNLPVLLGCQNCRDSVGYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV31</accession>
    <name>A0A5N6TV31_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannosyltransferase putative-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_172513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV31"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="55237" checksum="838A60B70AC6D62A" modified="2020-04-22" version="1">MRPSGRYRVILLVLSTVLILYSLHLYWRADVEFAAAAENVSLKERQTLLWQQLRSLLEDYEPDCPSPVRRDSSGAISFNANRAIPRPDLIVNADEIQEPLQQAHDGFVNAMQRVKPHVAHVPGTSGIVSSAGKSYLPLFVTSLRMLRRTGSTLPVELFVKDTSEYETHVCEEVLPQYNAKCVVLSDIFMVEDQFTTVEIAHYQLKIFAVLFSSFENVIWMDSDGFPLYDPESLVKAEPFASMGLVVWPDFWVSTASPLYYNVSRQSVPDMTERASSETGVFLVSKKTHMRTLLLSAYYNYYGPSHYFTLLSQGGPGEGDKETFVQAAVAVGDGYYAVSEKVDAIGHKKPEGGISGSAMVQSDPIEDYRLTSQGKWRVKDPSVAKPPRVFFVHAHYPKFNPAENLFGSQWETAPTMKQDGSDGRAWVVPENTLRRFGYDAERGYWEEIKWVSCHLEDTFESWQDKSGICDRVSEYWTNVFEGSDEVPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV58</accession>
    <name>A0A5N6TV58_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_172296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV58"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
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        <property type="protein sequence ID" value="KAE8150331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="426"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="622"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="865" mass="98821" checksum="7140F39B6DCD1048" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWB6</accession>
    <name>A0A5N6TWB6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_129361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP-bd_C"/>
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    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="519"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00501"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150675.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59687" checksum="3659A7B741C74332" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX87</accession>
    <name>A0A5N6TX87_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX87"/>
    <dbReference type="OrthoDB" id="4379169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="87" mass="9320" checksum="9194A665A6C83A8C" modified="2020-04-22" version="1">MFLPITSISHYHSLSYSIILLPRYSQTTTMRLTLIFSVFAAVAIAAPNACTPNGLPCNSQTNCCSGLCMVDDLDAEPQNGSCAQNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXB6</accession>
    <name>A0A5N6TXB6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXB6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="56" mass="6351" checksum="F5AA718F08B9EC19" modified="2020-04-22" version="1">MSWLCCGVLWVGFCVNCFWGFGLMLGGKVWGFSFLLLVYDGLCLFWVLVAYTILCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXV0</accession>
    <name>A0A5N6TXV0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_128977</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="16">
        <location>
            <begin position="152"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="17">
        <location>
            <begin position="1205"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="833"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1144"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="867"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1144"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8151208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1310" mass="146990" checksum="A8474B1A1E48C5EB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXX8</accession>
    <name>A0A5N6TXX8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_153568</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXX8"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ATPASEC"/>
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        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
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    </dbReference>
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        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
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            <begin position="93"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="16835" checksum="8D40525F97EFAB09" modified="2020-04-22" version="1">MASSRVFASRLATTMAATSKVARPATRVQIAAPKRTFTTQRKTAIPMTPFQTVKRQQPSLIQANARQVFANVQGRRQYSSEIADAMVQVSQNMGMGSAAIGLGGAGIGIGLVFGALLLGVSRNPALRGQLFSYAILGFAFVEAIGLFDLMVAMMCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY64</accession>
    <name>A0A5N6TY64_ASPAV</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAE8151267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="54" mass="6057" checksum="98730F34962F4672" modified="2020-04-22" version="1">MKCLSIPGQLDRKYHQSNHFTSPSVPSIQLLQVQPILSTSLSGNRATYRGSINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ06</accession>
    <name>A0A5N6TZ06_ASPAV</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_138791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="258" mass="30334" checksum="B8482316A27758D5" modified="2020-04-22" version="1">MPTNNRQLERKDRRAKLRVIRKKINRLGKGYLDDHDLKTAGVNRQLMSLEDKSILPRFFAPYQAKVDPPQDENVTDSFPRFDELIFEDHAESAQRFLHKYIQNGELPQDEEFPLVPCYKDWGDFGFPDLVEILGKPTWQLMTAWDMPLRKQPHIKCMLSTDAVAENRLLYSEIVTIIEIIRQRLRTRETRPHVDAPVFLYSFVDSSVRVLEGNFDGAELTVRATKLFDFSNDDRRGFELSLFLARWWYGDTTNEYTTL</sequence>
</entry>
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    <accession>A0A5N6TZ99</accession>
    <name>A0A5N6TZ99_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_128622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ99"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="562" mass="65157" checksum="A0464DC4361C92AB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U026</accession>
    <name>A0A5N6U026_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_151867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U026"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="132" mass="14151" checksum="B8526AAE8EC70CF7" modified="2020-04-22" version="1">MSERGSFRGGRGRGGGYDRSGGRGGHRGGGAGGGAQQQEKPKKENILDLSKYMDKEVRVKFNGGREVVGLLKGFDQLMNLVLDDVKESMRDDEGNENTRSLGLIVARGTLIVLISPADGSEEIANPFVQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U070</accession>
    <name>A0A5N6U070_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_151791</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U070"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8152026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="162" mass="16666" checksum="70427941A1905819" modified="2020-04-22" version="1">MENSEFSPKFAPFFSFAGIAAAMIFGSMGAAYGTAKSGIGISGVGQFRADLIMKSLVPVVMSGIIAVYGLVIAVLIAQDVQPPPTQNTSLYTGFMHLASGLSVGLAGVAAGYTIGIVGDAGVRAYLQQSRVYVGMILILIFGEVLGLYGLIVGLILNSKSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0F8</accession>
    <name>A0A5N6U0F8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_171097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0F8"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="295" mass="32216" checksum="79358E5A266E8EBE" modified="2020-04-22" version="1">MAEHWKSTPRYWCKQCKIFIRDTGFEKSQHEATAKHQGNLKRFLRDIHRDNERQQRETQRAKNEVERLRQTVAGGPAKSSGAGAGGAPPWKAAAAAAPRAPERPVPLEERKKQMAQLAEMGIAIPGEFRGDMALAGEWETVSETVVGEVDGKGLSRGVRKRKHVADEEEEEAKREAERFVSKGWGSRTREYPGAMDDGDLDALLASTAEVKKVKSSTVPDLTAPEASTAPGGKDGEIAEASRAEDTPAVELSQETPAKEESAEAGSVPLDLVAKTEEEATPGVVFKKRKPKVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0M6</accession>
    <name>A0A5N6U0M6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore Sim4 complex subunit FTA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0M6"/>
    <dbReference type="OrthoDB" id="3432781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025213">
        <property type="entry name" value="Sim4_Fta2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13095">
        <property type="entry name" value="FTA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="28912" checksum="12D07FEB6FA3CFD8" modified="2020-04-22" version="1">MQEVQQDEHYKLLLNLFLSEETLDVDFTSDSSITNLDEVVEQYPMLKRFVGHKDKITKPKLIGNGQQGFVFKFKHNERDLCLKLFYEFKGVYDDEEVTSYISPFGCESRAFARLCDLHQNGQWAVRCHGWMYLTDSQLQQLWEVSRPDPRWHGARWAIVKDFIAEEPPSREDENFQNVMAKFHIPKCGRILPRDVKKENYRGDLIVDLGSTVTFPFYRRYARWTEHIAFFQDLDTERIPEWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0T6</accession>
    <name>A0A5N6U0T6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetamidase/Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_151373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0T6"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.580:FF:000001">
        <property type="entry name" value="Formamidase FmdS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="410" mass="44841" checksum="4FC48127C798E0A5" modified="2020-04-22" version="1" fragment="single">MGNKGIRTALKVNLDKPAWEQPGLHNRWHPDVPSCGKISNNEVVKIECLDWTGGQIKNDDSADDIKNVDLTQIHYLSGPFDIETAEPGDVLLVEIQDVQPFEDQPWGFTGVFHQQNGGGLLDEIYPKAAKAIWDFEGIFCSSRHIPRVRFAGLIHPGILGCAPSAEVLSEWNRREGELIAANTTTRDVAKPPEPKSAHAGSAEESLKAKIGREGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGIITIKFTVIKDGMAKMGMKSPIFRPGPVEPQFGPGRYLTFEGFSVDGKGKQHYLDATVAYRQTCLRVIEYLRRYGYSDYQIYLLLSCAPVQGHIAGLVDIPNACTTLGVPMDIFDFDIQPEAEAVKMDMGSCAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1N9</accession>
    <name>A0A5N6U1N9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_137727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1N9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="101" mass="11675" checksum="0CDC93E7F3BE9795" modified="2020-04-22" version="1">MTEIQLQVHVQSTKIHQLTESQWPELLARRQWSNRLLSRIANSITDADLRSLSLPVCDIGLARRYVPAEFEGRVINDESAPLKLQMAVERAIRERLRDVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2K1</accession>
    <name>A0A5N6U2K1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_137558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2K1"/>
    <dbReference type="OrthoDB" id="10649431at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024936210" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="35830" checksum="C34D709CC161541C" modified="2020-04-22" version="1">MKQFLLLSALACLTAAQSTQDFFQALCSEERTGGTKRFPNGIIVDYYCNEGPVIAEATTTMPNINSPADCAKLCADAKGQCKSSVWLYAANACQLQPTAGKREPATGSLTMVLTGQNAAAGAGDVIAPLAQPAGCGGLHDQYQQCVIKEGQRECKDDLSKCEKGRQDDAKKCKDEKDDLKHKLKKCSEHGEGQACCQDLANCKDKVDRYRKQNCELLDRLANCQTTDASGNGNLLLAEIEMCPDIDSTQRTVGGVTYTIYCNRGIKEDTLVAKEQELAFNQCVAACSKDATCQGINYYPANDKPCVMYQSWANTPTAAGTRIMIAAIPVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U372</accession>
    <name>A0A5N6U372_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_44758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U372"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="333" mass="36706" checksum="65C25DAC8778495D" modified="2020-04-22" version="1">MASDSKGPTVSGVAVSFAIWTFIIICLRLFSRVFVIQRMGIDDYLIVVACLTSWAFSAVTVVSVEKGMGDHLEEMDPNNMETYALAVWLSSLFYLSTLGFIKSSVCLFYTRLGDRILTRLSIIMLCVIIAQASSFVLTAAFQCRPIEKAWNVAEPGKCVNINIFYLANAALNILTDVLTYSLPLQVIWKLQVPMKQKAALAFILCVGLFACISSIIRITYIPAMLSDPDATWVISEPMYWSVIEINVGIFAACMPSFKAIASRFQPRLIGEYSSGRGYAYSGNSDAKKDAGFAKIRGNNMQMGPLRPDRGEVDSVIGTQIGRDRSYRSPSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3B9</accession>
    <name>A0A5N6U3B9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_44741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3B9"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="61979" checksum="B9E4EAE7C6D2DAB8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3V5</accession>
    <name>A0A5N6U3V5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3V5"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="36"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="452" mass="50951" checksum="6E3354B64FEEDE83" modified="2020-04-22" version="1">MAKARTKKRTHVRAQNASAAARGSAAASSMNKTPKSMVIRAGASQVGSSVSQLVKDVRLMMEPDTAVRLKERKSNRLRDYTVMTGPLGVTHLMLFSKSATGNTNMRLALTPRGPTLHFKVENYSLCRDVEKALKRPRGGGQDHKTPPLLVMNNFNSPNATENSKVPKRLETLTTTVFQSLFPPINPQATPLSSIRRVMLLNRELSSDDTEEEDDYVLNLRHYAITTRKTGVSKRIRRLDPKEVRTREKRGVAVPNLGKLEDAADYLLDPSAAGYTSASETELDTDNEVEIAESTTKKVLTKRELQRMKSGEQEKAQKKASAGPEVEKRAVKLVELGPRMKLRLIKVEEGLCEGKVMWHDFIHKSEAEVKKLDKNWEEKKQEKERRRKEQKANIEKKKAEKAKARAEGKEVEDDDDEDVDMEDDEDDWLSDDFEDENAEDAGGDEDEDESMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Y3</accession>
    <name>A0A5N6U3Y3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_38834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Y3"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="264"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="437" mass="48010" checksum="813ED7BC1082B24B" modified="2020-04-22" version="1">MATISTIPFAEPPYLRLPSPYYTPAHRAFQKKCRAFLWEHLISNASTWEKEGQVPDHVFRTFCQHNMLLPNLPAPLPVQWLHKLGIREILDVPVAEWDYMYTGIYCDELSRSGLAGPAASLNAGFAFGIPPIIKYGSAELQERVLPDLLTGRKRACIAITEPEAGSDVANITTTATKSDDGKYYVINGTKKWITNGIWSDYTTMAVRTGGPGAAGLSVVLVPLKGYPGVTMRKLQIGGSRTSGTTYIELDDVRVPVANLIGREGEGMRIIMTNFNHERLTIAVGVTRQARVALSSAFQYCLKREAFGKTLMDQPVVRHRLAKAGAELETMWAWLEQILYQLCHLSKEEADRQLGGITGLAKAKAGMVLSECAQCAVLLFGGAGLTQSGQGELVEAIYRDAPSARVPGGSEDVLLDLAVRQMVKIYQVQEKKLRQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U487</accession>
    <name>A0A5N6U487_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U487"/>
    <dbReference type="OrthoDB" id="4468080at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="87" mass="9752" checksum="EC4D960AECC60ACF" modified="2020-04-22" version="1">MYPSSMPTRRYARGMYRRPYGPGGIGGLVKVAFIGTCTYLVAKKIFHAGQESVSRTDQRTAAVPYTPGSRHSYHGPIHHEAWNQSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Q7</accession>
    <name>A0A5N6U4Q7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_149091</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Q7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="553"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="956"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="923"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8153564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119294" checksum="89AB3185E4AF8D9A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5P2</accession>
    <name>A0A5N6U5P2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5P2"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="207" mass="22336" checksum="6A6FA4147BC3BF6C" modified="2020-04-22" version="1">MSTINTSTGTQPIDPYKAKNLEDPPLAQKIEDLVDFISESKFGMLTTRLSGSEYLTSRCMALAGKENGGIDLLFHTNLFSSKTLDLTTHPSEVNISFLDQVSGSWASISGTASIIADRATIEKYYSPTLPAWLGDLGDGVHDGGPSDPRIGVIRLEAKVATYAVARRGIFGRAVETVTSAVRGDVPGFNSIREVSGGELEEWRRTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5S9</accession>
    <name>A0A5N6U5S9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_126846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5S9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="AdenyloSucc_lyase_C"/>
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    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
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        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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        <property type="entry name" value="ADSL_C"/>
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    </dbReference>
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        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
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        <property type="entry name" value="FUMRATELYASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="623"/>
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        </location>
    </feature>
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        <location>
            <begin position="750"/>
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    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="877"/>
            <end position="894"/>
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    </feature>
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            <begin position="452"/>
            <end position="898"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="946" mass="104487" checksum="E71803467F7B9C7E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U752</accession>
    <name>A0A5N6U752_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135870</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8154436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACW-9"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024925943" evidence="1">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="234" mass="22960" checksum="D7D9693D5346A6D0" modified="2020-04-22" version="1">MQLTHFTAALLLSGAYAAYAPPSNEQTITVAEVSETPTPTEIPGGCNPAHPGSCPTPTEIPGGCNPAHPGSCPETTSTSIPGGCNPAHPGSCPESTEIPGGCNPAHPGSCPTPTQIPGGCNPAHPGSCPSVTVVSGSSTYLSPVPKVTPSSFSSIAGIPGGCNPAHPGSCSSVTVVSGSSTYVSPVPAATSSATFKGNLTNGDINLFMGAAAGTQVQYGVLLTGLMAIAARAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U797</accession>
    <name>A0A5N6U797_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative arabinan endo-1,5-alpha-L-arabinosidase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_136341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U797"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF5">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024830888" evidence="10">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="403" mass="45070" checksum="701768BCF38276FE" modified="2020-04-22" version="1">MLQIYIIHLLLLLCIVQALPSEKLKGHVFSVTKKYPLPNQGHLRAHDPNIIRHEDNFYLFKGGIHAPIWKSAGLSGPWTKVGTVLDGPTVIQKQNRTRPWAPTTVEWKGRFYCFYTVSKNGVRNSAIGVASTDSLESGWTDHGGIIYTKQGPRSHIWPYTVSNAIDPAFIADQETGQPYLVYGSYWDGIFQVPLADDLLSVKNAEKPDAKNLVFLPHVKVKPDEGAFMSYREPYYYLWFSHGKCCHFNKFPTMGQEYSVRVGRSKDVRGPFVDKDGKSLDDGGGTTVYGSNHGLVYAPGGLGVLSGNDTDPDILYYHYLNTSIGFRHSDAFLGWNYLEYKDGWPVARATKNAAPTRQPGYSFTVFAVLCMCCLALMLLPTRLPLQKLISLLLFTVTAGILLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7G5</accession>
    <name>A0A5N6U7G5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_172382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7G5"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="529" mass="60481" checksum="E8AD874DE8BD0D3F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7K9</accession>
    <name>A0A5N6U7K9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_1383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7K9"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="55"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="266" mass="29448" checksum="562C4EAC023816F5" modified="2020-04-22" version="1">MASFLPRAGFRVLTALPRATALPRVSLASKLPCVQPLQPVSRRFVASIPQEQPRLRLGSTAPNFQAQTTHGEIDFHQFIGDSWAILFSHPADFTPVCTTELGAFAKLKNEFDQRGVKMIGLSADDLSSHGDWVKDINEVGNTTVQFPIIADPERKVAFLYDMIDQRDLDNIAEKGIPFTIRAVFVIDPAKKIRLTMLYPASTGRNSAEVLRVVDALQTADKKGIATPIDWSVGEDVIVPPSVSTEDAKKKFGQVRELKPYLRYTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U820</accession>
    <name>A0A5N6U820_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U820"/>
    <dbReference type="OrthoDB" id="4508034at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="48587" checksum="17B2D4C6CEF40622" modified="2020-04-22" version="1">MAAASPEGEAWFFHNAIKIDGKFEPTDPKQFYNHILLEVVTNWTVDEGFQMPELPFKDHPRADKQCWDPASRTFYTRYRYMTVMTGHTCEDIKRKKAVNGSFSFNDLARQTGKNMIALVPVLVPDINERYLWFTSRSVTLDAYESSTSWENELEERLSDLGNAVGGNIGSQIGGTAGSTLGAALDGSWAGDASDMMRNDPLLNAEFEKREKAMEKEDKPVQPAIKANQVTLPNHKTAGWEFQPQWTARFDIFALARLLAIPTHLLNPNYKDPYRFIKLYNCKSVACPKPEKADSNMNPEEVVQFDKLLSVQIGSNFTYQGNGQDPNFLVKVLSGLVAVGLSCIPMFGPLIALGEQLIVDAILDPDSFKSQQGLISKIPGVASAMAGTAQNASGYLSKTASLSHAPPVLALEEQDRRSIYVGPGEPGVVNVSVWQRMRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T7</accession>
    <name>A0A5N6U8T7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_147072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8T7"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="339" mass="39605" checksum="D0A01DF640509D04" modified="2020-04-22" version="1">MENHTASKGRAAMKKVLTGIKTRIANKNRPAHKILFTPDILERILLTLDMRTLLLSKRVCRMWNDLIDHSPKLQAALFFQPIPETEFTGERHIPNPLIVDEVWPRYFRRTLNSRHRPAQECLCLPKVQSLQKEKAYLRPEASWRRMLLHQPPTSRVAFFTIIDFIGGPDYCYASWKPIEDCIRLMDLEIHIDSGALVPSTEAFFLWSDVRGALRTRKRDIHLEDVEPAVNQCLGKCDFIVYTMAQYLQFLNPKGKRDGFSCQFDRWAIESHAEIVRCSSYQSFWSIEKKRLQRKKFECRYRRKENEILALESSDEDDSSDEEDSSTRRSCSPYPGCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U959</accession>
    <name>A0A5N6U959_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U1 small nuclear ribonucleo protein of 70kDa MW N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U959"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1 small nuclear ribonucleoprotein of 70kDa N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="142" mass="16395" checksum="AB4425505724E3BD" modified="2020-04-22" version="1">MTDKLPPPLLALFQPRPPLRYVTPIDRAPEDVKRSTFGGVAQFLPDLKEYGEEHPYNATESWIQRKLRQKQEKKENLDKHLTDGLQDYEPTNDAQARGDPFKTLFIRIVKDTVTPKGSKKPHKGYAFIVYEREKDMKGIIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9I5</accession>
    <name>A0A5N6U9I5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9I5"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024816948" evidence="3">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="101"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="53135" checksum="09C300694F439A7B" modified="2020-04-22" version="1">MWVRNYLLALSACALQATAIEPTGTDHLSPRATKAIELNKGWRSLSENVLSKPYDPERYPDGIINLGLAENWLIQKELAQYLEDHFTIDPLVHMTYGEGAAGSPRLRKALAEFFNDYFNPTSPVHDYEIIVSSGVTSLIDSIAWNTCSDNEGIIIPQPLYNGFPSDIDLRSSAKLLNASYLWEDHEYNLDDVFDPVMIRKSLDRAWDEYAADGVAIRAVMIANPHNPLGRPYSEEGLLEIARFCGEHDIHFVSDEIYANSVFDNGEEVQPPAFTSALSLNLDGIINPELVHVLYGMSKDFGVSGFRLGALVSRNENLIQAAFGLDLLSWPSYIAQDMWAGLLEDKPKTKYFLDANVQRLGDAYGNITEWLDAKQIDYYHDGNAALFIWTHLIPADSTVTPEDLIAECRANGVNVGDGRNFLAEGEPGWFRLTFSYPTDMLLLGLERLEEVLTGFGLLSNGNEGRPERPARPGHSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9L3</accession>
    <name>A0A5N6U9L3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_126061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9L3"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024940482" evidence="10">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8155119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="494" mass="56522" checksum="C7C9239D2D5ED079" modified="2020-04-22" version="1">MWVFLFSVLLMFLMRNLYRLYLHPLSKVPGPKLAAVSHLVEFYYDVLRGGKYLQQVENMHKVYGPVVRISPSEVHVSDPRFYTEVYSAGGRKRNKSPKIASGLRAAESLPAIINHDHHNLRRRHLNPPFSKPATRAVTPTIQSKIEVVTAQFVRAYMKDPTHALIDLDPVFTALTADIVTQFTFGKDLRFLEDQKFNNVIVGTVREMTGQYHVNRFFPWLSPLLDVLPPWFMYTLRPKLAGMYEFQNRLNQQPETKENGSRALINVLSDPSRSPEERSPEFIRDNINILLGAATDTTSGTLLMGLYYLAQNRSLWLRVRQELGEMMPTPDSPASWPSMEKLPLLHAVFNETLRLGPISIRSARVPVDETLVCHGHSIPPGTCISMSARILHMNTEAFPDPYHFDPDRWLRADQQQHVKMMQALVPFGKGNRDCIGRYLATAEIYMILASIIRRFDVELYDTTPDDVAFTRDYIVGRSEKGVWQVKIRITGVVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9N2</accession>
    <name>A0A5N6U9N2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_167728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9N2"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="522"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8155316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="942" mass="105873" checksum="86333DBE96B471CD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UA69</accession>
    <name>A0A5N6UA69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UA69"/>
    <dbReference type="OrthoDB" id="4646997at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="409" mass="45685" checksum="A8D9D4E7C8A39169" modified="2020-04-22" version="1">MISTTSLCLPPPHTPRKNMGLAPYFSTVTSESVFRARFQAEKARPFSELHHVAASNWGRSHLLACRVLRREPVRQILPILSDYTIPSDVHPSSSDEIRAFLNGPDPTFTTQSEHYLVRRSNNVTTLGQIWAALATFVGSPDRRSRDLSGTPEGDEFDDDHYIEVEPRPTRFRCNSIQDNFLDSSRIQIGSSSPLHDSSQRTPSSLGYVDSDSHLLGVAPEDETLRLASCVIRHILYFAPPQDSLTEPTVVEFCDAKTRLAASTIVGQRSIVAIDDSSLCLRRQEPGRGFIAVKDRIALLEAKTQFQCLENGRPIISDSCLAQMVCEALAARLLDFVQGSHQSVIVINATQHYMCFLQFDISDEYILDFEDESSANFLHVSSTAWYDISQRSGREHVLANICAIMRLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDV9</accession>
    <name>A0A5N6TDV9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tom7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_166586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742488">
        <property type="protein sequence ID" value="KAE8144553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDV9"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="53" mass="6139" checksum="BA6AFE57E91FBE69" modified="2020-04-22" version="1">MAQFSEETKERISKVIDISRVAIHYGYLPLIVYLGYTYSEPRPSLFKLFSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEC0</accession>
    <name>A0A5N6TEC0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_166254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742455">
        <property type="protein sequence ID" value="KAE8144682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEC0"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000704">
        <property type="entry name" value="Ribosome biogenesis (Nop4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000822">
        <property type="entry name" value="Ribosome biogenesis (Nop4), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="318"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="503"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="727" mass="82164" checksum="D01F89FF461622CB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEJ9</accession>
    <name>A0A5N6TEJ9_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEJ9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="88" mass="10032" checksum="8A6CE837E35FC17E" modified="2020-04-22" version="1">MFSRRPQTINLIPELAGFKSAEVNVSTVETESDFSWIQKNCGGERDIKCLSMVENDDMGDELRTFSFSFLSFSFLSFYPPVVVRFCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEL9</accession>
    <name>A0A5N6TEL9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RecF/RecN/SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_166072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000006">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="845"/>
        </location>
    </feature>
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        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
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            <end position="510"/>
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    </feature>
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            <end position="845"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1178" mass="132941" checksum="A265849137E010DA" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TET1</accession>
    <name>A0A5N6TET1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742420">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="62" mass="7138" checksum="CDF26790409AF4B5" modified="2020-04-22" version="1">MVQCIGVQKGRIGARSGILFAFFYSSFSFIFHYFSLFLKCSKCVVEKSTAPDRNNRTIRYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFG2</accession>
    <name>A0A5N6TFG2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAP-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_134131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742395">
        <property type="protein sequence ID" value="KAE8145047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFG2"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="374"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="542" mass="60993" checksum="A5D054CC47635FCA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFM8</accession>
    <name>A0A5N6TFM8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_81510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742417">
        <property type="protein sequence ID" value="KAE8144901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFM8"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12941" checksum="C51E492D924FDF7A" modified="2020-04-22" version="1">MHATAALRTAARTPLIRFLGRRTVPQSVDHTPRPHPASPTGILPDSFAAYRIKAQQHGPLGRASFTQGAIGRNSGASLGAVQPKQGEFFDRTELPSRFHRLPWSEAEIEAIETGGASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG15</accession>
    <name>A0A5N6TG15_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_78555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742396">
        <property type="protein sequence ID" value="KAE8145041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG15"/>
    <dbReference type="OrthoDB" id="5334244at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="163" mass="17947" checksum="BF5C74E9AA6FD5C5" modified="2020-04-22" version="1">MNSILRTSFRLPTTKSLVPSTYSARRAFSLSPRTYGQSSYGGEGDTQSQQPNNPRNSPTRDIEHPGPAAPDVSKGSTTSKPQSSTTQEDRDEQDSEGTPTHMSPSNKAHPTITDGRQSPNLDSKGNPRSDVPKDVKKHNEEMEKRYDRPYNQIGDEGGVRKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGH2</accession>
    <name>A0A5N6TGH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_71394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742349">
        <property type="protein sequence ID" value="KAE8145407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGH2"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="273" mass="29313" checksum="079ADC1019ABA012" modified="2020-04-22" version="1">MPSIKPALQPLQTPRTMVFPSELQSDSGSTLSAGTGRSDEPLSTPITPPVAYTEFLKKFKPILSPVTGEPDFTKLSILKEKEASAASTSTSSTPNPTSSPTSNPTSNPTSQPASAGSATSKPNEVQVPRPVVTLPPPTPYTAPPVRRDPRSLRALRIPPPPRYSSTLETPRSATTIFSPYSASPYSASPYSAAPYSASVYSASAYPASPYSASPYSATPSDWRLRYWEGPHSAAPSGRFSVRHVITHTVTFKRTQLEDPPKGKRRKREASKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGS2</accession>
    <name>A0A5N6TGS2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_165002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742363">
        <property type="protein sequence ID" value="KAE8145291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGS2"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="255" mass="28072" checksum="2315B697D3FE588C" modified="2020-04-22" version="1">MARMNDAPSVAFFGSTGGCVLACLALALKNGCTSCALVRDPAKLQGLLRERGVLESQIDSHLTIVKGNSTDLEAVRRTLAPNGEPVDLVISGVGGKLLMGNPLKPVLNNPTICADTVRTVIEASGELERKPTLVVISATGMKNKHDLPLAMQPLYWWLLKCPLADKTIMEKTILEEMKKPEDRRAIRDYSIVRPSFFTDGEGEGLAKIRDGREDRPAVGYTITRNDVGLWLFENFVRRPLHQENRFLGQAVTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGZ1</accession>
    <name>A0A5N6TGZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_144508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742330">
        <property type="protein sequence ID" value="KAE8145596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGZ1"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="183"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="764" mass="87404" checksum="A7958080575482A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THF6</accession>
    <name>A0A5N6THF6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_62404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742315">
        <property type="protein sequence ID" value="KAE8145763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THF6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="54255" checksum="3FBA5425823D040A" modified="2020-04-22" version="1">MATEYKLPFELDNPSLLHFDSYVGNNWVQAKSGKRFEVIDPGTDLPWASCPTNGAEDVPSAVETAHAAFEQYKKTTPRQRAQWLMKWDALIREAKPDLAKIVTHETGKPLAESYGEIDYATGFTWWFAGEAERIHGTISVPAAPNRRVFTVKQPIGVAAALVPWNFPIAMVLRKAGAALAAGCTMVVKPSPETPLSTLVLGYLAQKAGFPAGVFNVLTTDLENTPPLSEALCKHPLVKKVTFTGSTRVGKLIASHCAHGLKKLTLELGGNCPFVVFDDANLDQALDQLMALKWRHAGQACITANRVYVQAGVYDRFAQLLKERTQQLVVGHGAQEGTTMGPVTTPRSIEKALGQVEDARRLGADVILGGNRVTGTKGYFFEPTILTGMTKDMLVSREETFAPIAALYKFETEEEAVQLANDTSMGLASYAFTKNIDRMWRLLENLEAGMIGMNTGNSSAAESPFGGIKESGYGKESGKEVAVNEYLVTKTGTLTIEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THT2</accession>
    <name>A0A5N6THT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
            <ecNumber evidence="5">1.1.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; D-arabinitol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.250" evidence="5"/>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THT2"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047038">
        <property type="term" value="F:D-arabinitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000240">
        <property type="entry name" value="SDR family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="310" mass="33294" checksum="0F3887CE0F2AFC75" modified="2020-04-22" version="1">MGSSQNEIPLPPTPEVRKKMPWIQLGEVDPASTLTPPPALFPESSKVEQRAAMRFSVSGNAVFTGGTGVLALASARALLEHGLSGIALLDLPAALDKGAAEVNSLRQNFPEARVLTHACDVTNAQSMDDIAQRVQNELGSVNILCCFAGIVNCADAKDLPVEQWRRVVDVNMTGSWISAQAFGRHMIASGRGGNIVLIASISGHRVNYPQPQVAYNVSKAGVLHMRNSLAAEWTRYGIRVNSISPGYMDTVLNEGADLEQWRQIWAERNPMRRMGSPQEITGPVVFLCSDIGGSYVNGTDIVVDGGGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI37</accession>
    <name>A0A5N6TI37_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_133280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742293">
        <property type="protein sequence ID" value="KAE8146013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI37"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="904" mass="101718" checksum="57FBC1755EED1740" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIU2</accession>
    <name>A0A5N6TIU2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="59804" checksum="12023E2727898EE1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKX8</accession>
    <name>A0A5N6TKX8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12/S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_41816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8147004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKX8"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="145" mass="15838" checksum="83CA25C7874C51A5" modified="2020-04-22" version="1">MGKGKPRGLNAARKLATTRRENRWADLHYKKRLLGTAYKSSPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVKVQLIKNGKKVAAFVPNDGCLNFIDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLX2</accession>
    <name>A0A5N6TLX2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_132167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLX2"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50346" checksum="913F04BAFE263504" modified="2020-04-22" version="1">MSRETDTQSKRVLLLVYLTAFLFFLGENIQQAPRTQIYEAIICRHMLPWNSGTARERCKGETVQEELAFLKGTERLLGALPTVLVIPWNMIAERYGRSFTLKLAFFFICWFSDSAPIRLILLAPLFEVIGGGPAIIATIMYLLAADVTTAETRTSTFFIIRAMCIAAAILGQLASSSLMTHNVWVPWFLGLICILLSAFAVPFVPKLITEDSLDENSLLRPDHNARDMGTLSQDGSLSKYTSIKCRLILVAKQLREGAQVVYGNASLTVLLVISFLGELCEDSLPMILLLYVSKRYSWEFAQTNFLWALGGAVQFIFLIILLPQINRILLARFGNTYAADLTISIASATVMSLGSLLLGLGFSIPVAVIGVIIMSTAGGLQSALRSLLTTVVSRDSVPVVYSIYTVLHVFSTSLAGPVYSGAFALGLKFGTEYTGLPFIVASGLAGLCLPLFLFARSPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM76</accession>
    <name>A0A5N6TM76_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_142744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM76"/>
    <dbReference type="OrthoDB" id="5391043at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="676"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114669" checksum="BB46B9BE176FD5F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMI2</accession>
    <name>A0A5N6TMI2_ASPAV</name>
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        <submittedName>
            <fullName evidence="2">Heat shock protein 9/12-domain-containing protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_32334</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="89" mass="9603" checksum="6101D27A583CA6CD" modified="2020-04-22" version="1">MSDTGRKDWSTKAKEQITPDSAKSTQDKIKETATDTGDRISRGFQPDDQKSAGQEAYDKAQRSHDNKQHGGASGSLLDKAKDAVGLGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMM9</accession>
    <name>A0A5N6TMM9_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742200">
        <property type="protein sequence ID" value="KAE8147588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
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        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
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        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="293" mass="31411" checksum="1B67C7780F4D8980" modified="2020-04-22" version="1">MARIRQGVLNARATPTVRHITPVVGQVDAQNGFGFVAAQKGMAAAVEMARVYGIGMVSVKHSNHFGMSAWLVQQAVDGGMMSLVFTNSSPALPVWGGREKLMGVSPIACGAPAGQECPFILDMAPSVAARGKIYKAARRGEKIPGDWALDGEGAPTEDPHRALEGVMLPMGGPKGSALAVMMDVFSGVLSGSAFAGHVTGPYDPSKEADVGHFLVAIKPDLFMGLEEFKERMDYLYRRVVGSEKMAGVDRIYYPGEIEQITREERLRTGIPFVQAEIDALNLEADRVGVEHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMQ7</accession>
    <name>A0A5N6TMQ7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_33656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742209">
        <property type="protein sequence ID" value="KAE8147399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMQ7"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36617" checksum="00F1D0FED86C9BB8" modified="2020-04-22" version="1">MVGILAETTLSVNDGPLTSDNATYLRPSDPNLPLDELRKRYDEDGYIFLKQVLPREDILEARRRYFEFLAPTGVLHEGTDPVEGVFNKEKSEQDYPGIGAGHADGNGRPGGESATQFVDRAIDAHYKDWYTKNVVNHPALYDYIAKFTGWGESTLTFKRTLLRNNIPGSKPIGVHYDQIFLRYGEPTAVTAWVPIGDIKINGGGLIYLEDSEPVGQKIENEFTEKAKKAGLTEEEAKFAFNSNMMATGLLSESPAEFAKEHGRRWLVSAFEAGDVVLHKPHMIHASTINNDQDNVIRLATDLRFCDSSKQYDKRWMNYYRFNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMQ8</accession>
    <name>A0A5N6TMQ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_29882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742198">
        <property type="protein sequence ID" value="KAE8147628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMQ8"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="151"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="436" mass="48576" checksum="17C3989992EC8B5A" modified="2020-04-22" version="1">MPPKSRFTRLDAFAKTVEDARIRTTSGGIITIASLLVVLWLVWGEWMDYRRVVVLPELVVDKSRGEKMEIHLNMTFPRLPCELLSLDVMDVSGEQQTGVAHGINKVRLSSAAEGGRVIDVKALELHSEQEAAKHLDPNYCGDCGGVPAPSGEKRCCNTCEEVREAYAQQQWAFGKGENIEQCEREGYAQRLDAQRQEGCRLEGVLRVNKVIGNFHIAPGRSFTSGNVHIHDLENYYETGLADADKHTMTHIIHQLRFGPQLPDELSDRWQWTDHHHTNPLDDTQQTTDEAAYNYMYFVKVVSTSYLPLGWDPLFSSAVHNSYESSPLGSHGFAYGSQSSIETHQYSVTSHKRSLMGGDASDEGHKERLHAAMGIPGVFFNYDISPMKVINKEARPKTFTGFLTGVCAIIGGTLTVAAALDRGLYEGVLRVKKLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMY2</accession>
    <name>A0A5N6TMY2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoD-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_131839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742193">
        <property type="protein sequence ID" value="KAE8147732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMY2"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024933515" evidence="1">
        <location>
            <begin position="20"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="625" mass="71053" checksum="A27242193C4198C1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMZ1</accession>
    <name>A0A5N6TMZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_29171</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMZ1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="17">
        <location>
            <begin position="77"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="83"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8147704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="449" mass="49589" checksum="42B968D6BE1064DE" modified="2020-04-22" version="1">MVMAPTACIPAEICMTKQCHDKPDFNYSQNLSQFSNHGGNDLPQSRLAAKEMVMDVLKKRAAEVDVDHCGPGEEDAFYVADMGEVYRQHLRWKMNLGRVKPFYAVKCNPDPEVLRLMAKLGNGFDCASKAEIDIALETGIDPSRIIYAQPCKTKSYLRYAAQMGVKQMTFDNADELYKIKACFPDAELYLRILTDDSTSLCRLSMKFGASMDVARQLLELAHELELKVVGVSFHVGSGAEDPAAFIKAVQDARLVFDQAADIGHELHTLDVGGGFTGETFEKFAGVLGEALDVYFPPHIRVIAEPGRYYVADAFTLAANVIARRDVRDPEDPDNDAYMVYLNDGVYGNFSNIIFDHQHPVAQILTCANAPNAATSQGIAYSIWGPTCDGIDVITQRITLPGLLDVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGASALLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNB9</accession>
    <name>A0A5N6TNB9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_142334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNB9"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="260" mass="28564" checksum="53BE13E4FEE03B72" modified="2020-04-22" version="1">MSTPSKATKSSRITIACNACRFRKQKCSGKRPVCTQCLQHNRICNWPEQLKRGPAKGYIEALEHRLHETENVLLRVLAQASDSQLSAALVGERQMRSDEYSPFLRAGKRGAEYWKEFPLDTVSSVRRWQRDCSGFGGGASGRDVGVDADFGTRSPGERAKGKAVRGYDRSSSQVSCDAHPSRSLGDGGRVSSRSTSPIADKQQDKSGVEKTGTPIQDTTARLTSAEQSQADVVPDRSSTPREPNLWSGAPSVNFQQQFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNE4</accession>
    <name>A0A5N6TNE4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_159447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742187">
        <property type="protein sequence ID" value="KAE8147868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNE4"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="76"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="418" mass="48027" checksum="472094A58B7383C7" modified="2020-04-22" version="1">MDHQPDVDDKHESDNLREHLENTQDAESERASQTSETSQSDEKASYVAEKEDAIRRACDLRDLDALVSYATSEGGFLRDDIRQLAWPILLQSDKTPELPEWTKLSPHADEDQVQLDVNRSFVYYPNCTDAELLSKKDELSSLLKQVLRHYPMLCYFQGYHDIVQVLLLVMGGQKAAPAVTRLSLFRIRDYMLPSLSPTVKHLQLIPAIMERADPALRRHLADIQPFFALAATLTLYAHDIQEYSDIARLFDFILAREPVVAIYLFVAIILSRKKELLEIPEDEPEMLHFTLSKLPCPLDLEGLISSAVKLFNDYPPESLPAGTWNKIPQISVLKSSRDIFDPRPTEEAIDLFERQARQLRYEERKEKAIGFLWQHRRTIGTVAATIFVGAISIWMRKKGLDMTLWSYINRVKLAFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNZ8</accession>
    <name>A0A5N6TNZ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_159486</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="ML742188">
        <property type="protein sequence ID" value="KAE8147849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNZ8"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="254"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="571"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8147849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="769" mass="82375" checksum="222A9A9784628254" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPH1</accession>
    <name>A0A5N6TPH1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_158686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="ML742168">
        <property type="protein sequence ID" value="KAE8148256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPH1"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="233" mass="24913" checksum="8276168051FD157B" modified="2020-04-22" version="1">MSLETDPTLNFDSIEDTLKAFKNGEFIIVLDSQDRENEGDLIIAAESITPAQMAFLVRFTSGLICAPVSPDIAARLELPQMVIENADPKGTAYTISIDSSDPSVTTGISAQDRALACRTLASPTARVEDLRRPGHIIPLQAKSGGIRERRGHTEAAVEFCRLAGKSPAGVIAELVEDGELVPGVPEIGGNNGMMRRDGCLKFGKKWGIKVCTIEDLVEYVEKTQGSASVNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPR9</accession>
    <name>A0A5N6TPR9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_158534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742165">
        <property type="protein sequence ID" value="KAE8148324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPR9"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="932" mass="103553" checksum="2595891BD4F4EBB7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ34</accession>
    <name>A0A5N6TQ34_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_17391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742160">
        <property type="protein sequence ID" value="KAE8148445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ34"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="159" mass="17838" checksum="957B6B2C35F7E057" modified="2020-04-22" version="1">MNIELDGIAPDRGQTGNDVPQEEEPNLPIHSRGVHAKKEHGRLQVWWAKHIRPELTAEEGDPRDYLALERTYLAYTRTANALASFAVVASQLFILNDESVVAGKVLACLSLVFAIYITIVGCIRYFKQQGSLQQNKCCLWNPDSIRVALVFFVVSVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ36</accession>
    <name>A0A5N6TQ36_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_141794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742161">
        <property type="protein sequence ID" value="KAE8148410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ36"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="160" mass="16906" checksum="5968920FE0DC7D3C" modified="2020-04-22" version="1" fragment="single">MASRLAKSAIGAARLRPTLPVRNVAAINLTASRSASNVPTEDPKKKAQSILDSLPGNSLVSKTAVLSAAAGLSIAAISNELYVMNEETVAAFCLLSVFTAAAKYGGPAYREWAEGQVQKHKDILNAARADHTNAVKQRMDNVKELSGVVDVTKQLFAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ71</accession>
    <name>A0A5N6TQ71_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_168558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742167">
        <property type="protein sequence ID" value="KAE8148271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ71"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="48584" checksum="3CBF3F74D216281E" modified="2020-04-22" version="1">MSSPTDTADPNQTKVIIVGIGIGGLSAAIECQHKGYKVTVFDRITQVEKKKGDVIGIAQNGARVMATWGNGEFFERTRDLRYQSDGGVIFDSTGRHVVTSTMPGYRPDEGFVFNRGACVSAMYDYAVSIGVDVRLGAEVTGYWEGECEAGVIVQGERMAADCVVCAEGINSRAMIAITGYDFEERSTGISIIRGNLDAGLLVGDPDLAWVLELSGADKGYMWHSGTAQFSIWCKMGCTPELFWYGAYKDEECKDPNPVGPILEAIKDWPVKNQLEPIIHKAPTQRIIRQKLTHREPLKTWLSPGCRIIVTGDAAHVPVPAGGQGGSQAIEDAAVLAICLELAGKENIPLALQVTEKIRYRRATEVQKRSREMLEKSHSMSLEQMRRGEIPFLYLIPYWFYGHDCQSYTYKEFPIVVEAIQSGREYLPRNFAVDDSIHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ72</accession>
    <name>A0A5N6TQ72_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_141708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ72"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="639" mass="69873" checksum="5742AA1CC9068AED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQC3</accession>
    <name>A0A5N6TQC3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_158529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742165">
        <property type="protein sequence ID" value="KAE8148321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQC3"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000024">
        <property type="entry name" value="Similar to exosome complex exonuclease RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="269" mass="28444" checksum="07D65EFA3967E886" modified="2020-04-22" version="1">MPLDTSTTYPLTRLRLDGRRWNELRLFQAQISTNPASSGSSYLAMGNTTIMCSVHGPAEGRRGDATGGAAGASGAVVEVDVNVAGFAGVDRKRRAGGSDKQSSRIATTLRAAFQSHLHTYLYPHSTISIHVSVLSSDGSLLAAAINACTLALVDAGVPMPGLLCGCTAGMSGSASTPRDPRNDELDPILDLSLPEEQELPFLTVGTTTSVPVGENAMDDDEEEMKVSMLNMDSKVHCTYVETMLAVGIDGCKQIREIMEGVVKGSNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQF9</accession>
    <name>A0A5N6TQF9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_141720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="9">
        <location>
            <begin position="9"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="2038"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="2390"/>
            <end position="2418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="3142" mass="357183" checksum="83488DFC3EE09C43" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQN5</accession>
    <name>AVEC_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nonribosomal peptide synthetase aveC</fullName>
            <ecNumber evidence="3">6.2.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Isoindolinone dipeptide biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aveC</name>
        <name type="ORF">BDV25DRAFT_141604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="1106" last="1106">
            <title>A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <person name="Kjaerboelling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Petersen T.I."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J.M."/>
                <person name="Maekelae M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Pangilinan J."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="de Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
            <dbReference type="PubMed" id="32107379"/>
            <dbReference type="DOI" id="10.1038/s41467-019-14051-y"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NRRL 4517 / IBT 18842</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="J. Am. Chem. Soc." volume="147" first="18923" last="18933">
            <title>Genome Mining of Isoindolinone-Containing Peptide Natural Products.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Wu L."/>
                <person name="Wang Z."/>
                <person name="Han W."/>
                <person name="Kerr T.A."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="40387549"/>
            <dbReference type="DOI" id="10.1021/jacs.5c03321"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Nonribosomal peptide synthetase; part of the ave gene cluster that mediates the biosynthesis of the dipeptide L-Leu-L-Cl-Isd also called isoindolamide A (PubMed:40387549). Within the pathway, aveC is a monomodular NRPS with an inactive condensation domain which activates D-alanine and transfers it to the starter-unit:ACP transacylase (SAT) domain of PKSs aveA (PubMed:40387549). The alanine racemase aveF first catalyzes the interconversion between L-alanine and D-alanine. D-alanine is then activated by the NRPS aveC that transfers it to the PKS aveA to produce R-dihydroxymethyl isoindolinone. The flavin-dependent halogenase aveE catalyzes C-6 chlorination of R-dihydroxymethyl isoindolinone. AveG then catalyzes the gamma-replacement of acetate in O-acetyl-L-homoserine (OAH) with C-6 chlorinated R-dihydroxymethyl isoindolinone to generate the amino acid chloro-O-isoindolinone-L-homoserine (L-Cl-Isd). Finally the ATP-grasp enzyme aveB acts as an amide-bond-forming enzyme that activates the carboxylate of L-Leu for condensation with the amino group in L-Cl-Isd to give the dipeptide L-Leu-L-Cl-Isd also called isoindolamide A (PubMed:40387549).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>holo-[D-alanyl-carrier protein] + D-alanine + ATP = D-alanyl-[D-alanyl-carrier protein] + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:55132"/>
            <dbReference type="Rhea" id="RHEA-COMP:14102"/>
            <dbReference type="Rhea" id="RHEA-COMP:14103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138620"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.54"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase. AveC has a monomodular architecture with an inactive condensation domain (C0), and adenylation domain and a thiolation (T) domain (C0-A-T).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.54" evidence="3"/>
    <dbReference type="EMBL" id="ML742152">
        <property type="protein sequence ID" value="KAE8148645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQN5"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000462909" description="Nonribosomal peptide synthetase aveC">
        <location>
            <begin position="1"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="786"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Truncated inactive condensation (C0) domain" evidence="6">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation" evidence="1 6">
        <location>
            <begin position="257"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="40387549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="40387549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="40387549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="911" mass="99927" checksum="439E6175BC42AD82" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRX5</accession>
    <name>A0A5N6TRX5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742134">
        <property type="protein sequence ID" value="KAE8149106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRX5"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000141">
        <property type="entry name" value="Acetyltransferase, GNAT family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="151"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="285" mass="32261" checksum="255C68B9315DCF60" modified="2020-04-22" version="1">MADFTDNKSAEQPINGFKPLSNVDGFPLPTTGDDLSRLSDRVDYTMANGIPMDEDDDDDEEVDEDYVAVDQDDLNNEFPYWFRRPPMHQRTKLDELHPFVQVLTVSNVDDCVSVESAFPEQERCSREKFIYRLNRCPELCLGLFTLPIVGEDQPKPRATLVGHIVATRTSTAFVTDKSMDLPANWQTERMTVENGEAVGHDEYGSTIAIHSLAVLPEHQGKQVGSTLMKSYIQRIREAQIADRISIIVHDHLVSYYESFGFENRGPSKCQFGGGGWTNMMLEFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS48</accession>
    <name>A0A5N6TS48_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_4960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000119">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="745"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1559"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="909"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1257"/>
            <end position="1287"/>
        </location>
    </feature>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8149188.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2061" mass="225357" checksum="6373DA28323CCB75" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS60</accession>
    <name>A0A5N6TS60_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BDV25DRAFT_156763</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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            <name>pyridoxal 5'-phosphate</name>
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        <text evidence="2">Belongs to the threonine aldolase family.</text>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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            <position position="252"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="44627" checksum="4F72F4B582F0344A" modified="2020-04-22" version="1">MRPFTRLLTRPFLRSASPVQRLGYGHKFIMTSATTASNVSGNKPNSWQGAGLAEFDLRSDVMTKPTPSMLEAICQTTLLDDVFQEDPTTTDLQAYIAQRTSHEDALLVMSGTMGNQVAIRTHLTHPPYSVLCDHRSHIVCYEAGGVSSLTGAMVQTIVPKNGKHLTLEEIQKHAVLDDDIHHCPTKLISLENSLDGLVLPLDEARRITEWAHSNGIKVHLDGARLWEAVVSGAGSLTEYTTLFDSVSLCFSKGLGAPIGSIIIGSKEFIKRARWFRKAIGGGVRQAGVIAAAARVAVEETFGPDSSGQEGKLRDTHAKAKKVADLWTDLGGQLKVPTETNMVWLDLEASGLGPNDLAEIGNGQGLNLMGNRLVIHYQVSDEAIARLSEVFKIAMSGQFQRSTDHSKAYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS82</accession>
    <name>A0A5N6TS82_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS82"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23589" checksum="4CCC818E53D09C8A" modified="2020-04-22" version="1">MAPKRSRDVDAKPEEQQRTAEPPVKKKKGFSVGPANLPDGTYRRKTQKLKADLIQKAKVKKAYAKVKAEELAAAPRKSVYERALELEEKEHNSPQIEPASLELHPDRQAMLDEPVPERAPKPERSQNRDRRNRKPKPSAFAKEMELAEKRKQEAQRRQEERDFRQKDREAMTRARRPDQQGKRRLGRESTVLLNRVQRMVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSI9</accession>
    <name>A0A5N6TSI9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_4071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742127">
        <property type="protein sequence ID" value="KAE8149322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSI9"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000112">
        <property type="entry name" value="Mitochondrial carrier protein (Pet8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000123">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial S-adenosylmethionine transporter), member 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="33880" checksum="101546F6319DC20C" modified="2020-04-22" version="1">MSQSVETDPLVSPWTRSLISGAVAGLTVDCSLYPLDTIKTRLQKARHHTPSGPSTSLSLRQTIRGIYAGLPSVLFGSAPSAASFFIVYDGVKRTLLPASSSETPTRTQVILTQSLASSMGEISACAVRVPTEVVKQRAQAGLFGGSSLLALQDILALRHADPARGLKGGYGQVVRELYRGAGITIGREIPFAVLQFTMWESMKEAYAKRLRRGEQIPASTSAMFGSVAGAIASGLTTPLDVIKTRVMLARRGDSGDGAAVRVRDVVREVSKEGFGAFFRGIGPRVMWIGIGGSVFLGSYQWAWNALERRRESEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTI1</accession>
    <name>A0A5N6TTI1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTI1"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024803266" evidence="3">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="247" mass="27275" checksum="33350AE7111A7AB8" modified="2020-04-22" version="1">MYFSKLLLGFFSLFVSTPTHAGDFSYNEPSTAWANLPAGSSIPVERVRLSFSPDEVLQMQDSLKHARHSYLNSGDRDQNDWISRASDSWSEITVPNLETDLNRHPQFNASLAVDGQSSNIHFMALFSQEPAAIPIVLLHGWPGNVAEFSDLFDIFRSRYSPADCPFHLIVPSLPGYTFSSGNPILDRADLVRVTRTIDRFLADIGLDNGYIAHGGDIGSYIARMLGSYSSNCKGGLFPDGTCSLRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTY0</accession>
    <name>A0A5N6TTY0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial Rho GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Probable catabolite repression protein creC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">BDV25DRAFT_140411</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTY0"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000127">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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    <accession>A0A5N6TU68</accession>
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        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BDV25DRAFT_155572</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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    <sequence length="887" mass="97532" checksum="EAB6D2BE3DCED3B8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUI9</accession>
    <name>A0A5N6TUI9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_155310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUI9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="73" mass="7665" checksum="7C85913E39E167E2" modified="2020-04-22" version="1">MLSPMSLPSLASHLVSTLAPLACLPFLLPLDLLLTTSLPPLPVTLSPPRLSSPVLSLTRFPPPRTSALLALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUK4</accession>
    <name>A0A5N6TUK4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUK4"/>
    <dbReference type="OrthoDB" id="2588474at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110:SF1">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="357" mass="38822" checksum="EC042B9B4336C36F" modified="2020-04-22" version="1">MTVRKLERDDCIVTDRGGIVENRHQIHAAVTDATGKILYSVGDPSRITLARSAAKPAQALAILETGGFDQFGFDDADLALMCASHSSEDRHVDRARTMLEKTQAREEDLRHGGHPAVWEVVNRVWIKNDYTPTALCNNCSGKHVGMLAGAMAIGVGIADYHLPSHPIQLHVKSVVDELCGLDEGISKWCVDGCNLPAPAFELHYMARLYASFAAAADAPGQDENTNDRIQHMGRIFRAMAQYPELVGGHERFCTVLMESFQGELIGKIGADACYGVGVRASEQTRRLGAEGAIGIAVKVEDGSIPILYSAEAEILEQLQIGTPAMRQSLDGFHYRSIKNTAGVVTGRTSHLFKLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUN5</accession>
    <name>A0A5N6TUN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_118834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8149994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUN5"/>
    <dbReference type="SMR" id="A0A5N6TUN5"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024890942" description="Chitin-binding type-4 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="251" mass="27591" checksum="97BE1DA3F52FF3E6" modified="2020-04-22" version="1">MKPVTCLFTLGLATSVAGHGYMYIPSSRTKLGNEAGVDSCPECAILEPVESWPDLDAAKVGRSGPCGYNARDGIDYNQPTSNWGSEAVKSYKAGEEIEVQWCVDHNGDHGGMFTYRICQDQSIVDKFLDPDYLPTEDEKQQAEDCFDKGLLSCTDVDGQECGYSADCSEGEACWRNDWFTCNGFEASESPKCQGVDNSELNSCYTSIAGGYTVTKKVKLPDYTSNHTLLSWKWNSFQTGQIYLSCADIAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUZ6</accession>
    <name>A0A5N6TUZ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_154925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUZ6"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001680">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit (Pwp2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="751"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="900" mass="99574" checksum="ABF31AE754FCA927" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV57</accession>
    <name>A0A5N6TV57_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV57"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48080" checksum="4BB588F4B19BA74B" modified="2020-04-22" version="1">MSEQKRYALIGTGGRAMFFYTAIVRDFQHTAELVAFCDTNTTRLAYANSRIEALGHAAIPSYHAADFDRMIDETDPDEIIVTTIDRTHHQYIVRGLERGCNVITEKPMTIDAPRCRAILDAVERTQRQVRVTFNYRYAPHNTRIAELLASGAIGDIHSVHFEWMLNTSHGADYFRRWHRDKRNSGGLLVHKSTHHFDLVNFWLGTKPESVVAMGDLRFYGKENAERRGETQFYSRTRGSEVAARDPFALDLEATETLQKLYADAEWEDGYYRDQSVFGDGISIEDTMGVMVRYRTGAVLTYSLTAYAPWEGFRVNFNGSKGRLEVEVVEQSYVNSGGEQALEGALESRTILLRPLFEKPVEIDVPTGSGGHGGGDPQLLEDLFGSRSPDPLNRAASHLDGAWSIATGIAANESMRRGQMVRVDDVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVI2</accession>
    <name>A0A5N6TVI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Structure-specific endonuclease subunit slx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_117557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVI2"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="11">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150109.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="403" mass="45187" checksum="C14EFF11C9290417" modified="2020-04-22" version="1">MANVYDGVVKPIPAFYCCYLLRSTVRHSSLYIGSTPHPPRRLAQHNGVAKGGARKTANDKRPWEMTVIVEGFTSRVAALQFEWAWQKPGLSRHLDPNQDESNSTEPQPHADSTRQAKPRARGPARSLKKHIENLHALLRSTYFSHWPLKVRFFSADAYQLWRIWSDRVNGAIPKHIGIILDGGCADDNQPGTGNPRVGSVQQIQPDYSKISGYLEKAAFRLDDPGDLRCSICRVLVDPKDELVVVCPQERCYCINHLLCLSARFLDSTRDPERLVPMSGTCPECRQIVEWPLVMQELTLRNRGKKELEAVLRKKKRSDGRTIAAQSDIGTAAVETRGSLPSADTQTGWKDGLDENNPEDFPLDEDWIESLAPESDSEMGDPQRPLPVGPSRVEIVIEDSDCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVI7</accession>
    <name>A0A5N6TVI7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Cell cycle inhibitor Nif1</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">BDV25DRAFT_113137</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742097">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVI7"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="82185" checksum="409BA767B0D22741" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVQ1</accession>
    <name>A0A5N6TVQ1_ASPAV</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="81" mass="9529" checksum="4A332B55BE7EDED0" modified="2020-04-22" version="1">MPPLAKYLSRPDSHLSMWMSHHREWDDSRNREKEEALQSYTSGIWELEEEPAQRSNAFCYIGDWGTGCDYYADFASWGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVZ6</accession>
    <name>A0A5N6TVZ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_129467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="110"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="404" mass="42930" checksum="0FD96D46A8672C21" modified="2020-04-22" version="1">MQAAQGGDSRYETITPLLNKLARFDEATHQVDPDEIAQGLSLLLNDKLTETQSSALLSLLHHKKKDRDVSVIAAAIRRIVQPKIDAARIQNIISTRGKPEGDYLGGLCELTGTGGNATPTLAALTTTASLIASSSLLVSQHGYMGANSPTADLGNDAILSNIQPTPPALSSTPENIDKVLKESNYIFLPEPSFYPTMKHANSIRQGLGIRTIFDLVSTLLHPLRGHLEARVIGVSNPDLGPAFAQALKDTAVKKALVVSGQGLIDRISPQGSTSCWMLSGGEGTVQHFNLQPSDFGLPEQPFGAVKARSSAAEEAGTLVDILQGKLEDDDPVLQIVLMHAAALLVISGICEVDSGEIGQEHVIEERGPGGQRWKEGIRRAKYSIASGGASTALKTYIRAPQDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWM1</accession>
    <name>A0A5N6TWM1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">High osmolarity signaling protein SHO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">High osmolarity signaling protein sho1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 8">Osmosensor SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein BZZ1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_105515</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BZZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWM1"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="17">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="577"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="683"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8150782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="741" mass="81943" checksum="04BFAEFF95C869B0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWU7</accession>
    <name>A0A5N6TWU7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese/iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWU7"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="298" mass="33451" checksum="9075143A0A9E0CCF" modified="2020-04-22" version="1">MLPRLFRPQSTLRAVSPLTQKPISALPRFQFRGLHHVPKLTHDAQFKASGVPQLLSPEAFDFAWTQYQSLLINKLNLLTQDTVDADAKPGELLVKYSRRPEMASVFNYASMAHNNHFFFNCLSANPTEIPDKFAKDIVDTCSSVESLKLDFLATANAMFGPGFVWLAKNLEREGLMHIFCTYNAGSPYPAAHSRRQPVDMATHTLETQLGNQFAGAMGAHSANQKSMAPGAVDVQPILCVNTWEHVWMMDYGIDGKAEYLERWWDSINWDVVFDNYNAVSSVKGARHAANRNRSLSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWZ6</accession>
    <name>A0A5N6TWZ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_103397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWZ6"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="247" mass="27937" checksum="86F8E87E7F5F1643" modified="2020-04-22" version="1">MAFARSHALTRNAFLKPPEKEVPIKRQNAFLEPLEDEDVQLPDEALKRKRKASVYDAVAGRINAHGFLPSAPYASRYRDTASSTTRSVRPEEVLFRRQNAPIRYEENDFYFAHESLPSDRPLPTSDLLESIHTYSADFYDNATVDRGQDDYCSMDETALIAMGILMEEMAKESLGATGDLVLVEGEELESIEDFKSEPRRRFGRKRTNTGRSSVLQSSGDELEGVVRKNKRTKKRHVSQTASTTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX67</accession>
    <name>A0A5N6TX67_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_129359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX67"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="54"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="55617" checksum="3A6775E595085C2A" modified="2020-04-22" version="1">MIPRNTRSRGYFLQPWELSTLEDAEGHLQRLDFQPFQLQNLVNGALVPHPHNNWIDSVNPKTGLRFACIPNSSPEQVHAAVSAAEAAFPTWSATLPSLRSEYLQRIASRIEEQRELFAAWESIDQGKTLSRARVEIDRAVANFRYFATYILHQETRARWTDTNILTYEHRSPKGVFALIAPWNMPLCSLTGKIAPCLAFGCTAVAKPSELTSMTAYLLSTVFRDVDLPPGVINLVYGAGDPTGSALVRHPRVKGISFTGSTATGRQIRRDTVDDIGKYLSLELSGKNPTIVFDDVDVDKAVVTAAKAAFENQGEICLCGSRIYVQRRLWSEFVCRFVSYVREHYVLGNKVGAVVSLDHYNKIRSYLTLAAEDPISVFHLGSIPPENPECGFWIEPAVLTVSESSPLLTDEIFGPVVTLTPFDTEEEAVQKANGSAYGLASILLTKDGARMRRVGEKLDAGLVWINCWLAKEMGASFGGISVSGTGGDSSREVYTSGRTLHIPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYT0</accession>
    <name>A0A5N6TYT0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_152530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYT0"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="47"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="18767" checksum="0C191140535F8453" modified="2020-04-22" version="1">MNPFRSPFNRGAAWQRVGLASEFPEVSTDNESCRVTSRCKAFRIPATNVPGEPEGPVETSIRRPGELKDQVLVFKYKGKMHAVDHQCPHSSFPLSQGSLFDIEDFGITLSAGITCPKHGWSFDIFSGQGDRGNYKLKVWEVQLRDPSTPTEDASDQEVWVRRKQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ37</accession>
    <name>A0A5N6TZ37_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_152477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ37"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="53"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="457" mass="49895" checksum="9B5C9D7A7E2BDCBE" modified="2020-04-22" version="1">MTMHREPESPTIQNNPNYDDTFTDVEKKQFEDEAPANDPFGSEECGEVKYRVMSWWQCGMLMIAENMSLGILSLPSAMATLGLVPGVIILVGMSGVSWYTGYVIGQFKIRFPQTHSMGDAGELLLGRVGREIMGTGQLLLLIFLMASHILTFSVLFNTITGHGTCTIVFAVIGMVVSFIGALPRTMNKVYWMSVASCISIIVATFVTMISVGVQAPAHVQVDATRDVTFQDAFLAVCNIIFAYITHVAFFGLISEMRDPREFPKSLSMLQVVDTSMYVVTAIVVYRYAGPDVASPALSSAGPVMKKVAYGIAIPTVIVAGVIYGHVACKYIYVRIFRGSDHMHQKSLLSVGTWVGIALALWVIAWVIAESIPVFNDLLSLISALFGSWFSYGFPAIFWLMMNKGVYFSSPKKILLTIVNLIILGIACAICGLGLYVSGKSIHDNSNNSSWTCANNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZA5</accession>
    <name>A0A5N6TZA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZA5"/>
    <dbReference type="OrthoDB" id="4752469at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="156" mass="17047" checksum="0F7DBA832FBCED7B" modified="2020-04-22" version="1">MSCQDQETLTCCTAPPGRENFDWVRATSAGPAGVLAFFETDANGDCLRCSSTGVINSRYHNVHFETTMMINAASACPRHAKKTTAGEVLDNSTSLYKATRQVDTLTVGGYDYNISHLPLEELVKDIAADLPDQELLKKWSLDQDKATLARDVIDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZV5</accession>
    <name>A0A5N6TZV5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_128415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZV5"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35596" checksum="04261CE09BA46184" modified="2020-04-22" version="1">MASSLSKGSLFSPVRSQNPIYQLYSCQCRLFSHSSQRNALRGAPENIAVKQPPQPSMKTRGKTMSRHDLPQDLGVLPGTFIKPRWRELPSIFQFPRERLQFEWLWIKTGFMNFASLVAYSKWLHKLPLRLKERRQVARELHQHMYSAFAKGDVGTLRKICCTGLANNLKYRIESRPKDEKVTWSLDKYNRGLSTLLTGVRVVSDRATQIPDLADSGIRQVVVRITSKQSTGKFKVDKSGAPVEESTPTKQQDCTEYIVIQKLRWLGEEGEWRLWGHTTFTSMDDLSSPAFAPGLTLNERMEGMKDEMMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0S9</accession>
    <name>A0A5N6U0S9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_75389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
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                <person name="Magnuson J.K."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">IBT 18842</strain>
        </source>
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        <property type="match status" value="1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="LaButti K."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    <sequence length="372" mass="42451" checksum="39F0E9F068CE22E5" modified="2020-04-22" version="1">MSYMPSSLELVGWPAWSTLFWFSLASGVLILVKRSSGHQKGAFQESNVHAEPTAYPPVEPLPDFEWQTKEPLKLRPFKPKYNLTMAIEEATVSELIEMDKNYADRIALRKALMTDHPETVLGAEQCVAAAVNEFYSWMVETYLPTRFPRMFRLSPPFKPSILHNLVTNEKLPLRAVGHPIETLRVLGGLVDEDVLFLLPSDDGDGYTLKGFVTCFPNGFNTKEKLNVKLRDIHKPVPKYKEKLEKSMDRYFDKLKVGKFMKRANWTITTTPNLAFFQGTHLYEGDTVSQEEVNVENARFRCERQVVHRLPQSRAIILTIKTYLYTLSEIKGEGLGESLAQAIDGLREGNVPAFHFYKRAAIWGESAKAYLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Simmons B.A."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
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        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="570" mass="63492" checksum="906583A6E72F05EE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1G7</accession>
    <name>A0A5N6U1G7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_138256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1G7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821134" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22834" checksum="118856230989AD7A" modified="2020-04-22" version="1">MLYILIIITLYLTALATAGLPLPPEPVKDLKTENLLSHCLEITITNEIREARGRSAIRGPRPLSPDVSPDPPRSRQRGPLQRRDLPPLYMRAKCRNSPTDAFHYSRLELDKCLGLIHEDSEYTLIAMENGDGIKKAGCRACTYGNYVPYPNTNFVYPYQIICTCRMDTMILSLRFDGRGVFEYDSKSGRLTCFKNQGTLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1J3</accession>
    <name>A0A5N6U1J3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_65015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1J3"/>
    <dbReference type="OrthoDB" id="4455544at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111985" checksum="533EA1568C05B531" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1Y2</accession>
    <name>A0A5N6U1Y2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_170657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1Y2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062248" evidence="8">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="9">
        <location>
            <begin position="401"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="562" mass="61599" checksum="AC4F7E768CB7D685" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U232</accession>
    <name>A0A5N6U232_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_60138</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U232"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8152646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="36224" checksum="C7D30788351A5394" modified="2020-04-22" version="1">MSLGRVFKLNSGYEIPAIGLGTWLSKPHEVENAVETALRAGYRHIDAAAVYQNENEVGLGWKKSGVPREQIFITSKLWNTHHHPEHIEEALDKTLKDLQTDYLDLYLIHWPVAFEHATDTLTPIDPVSKRFRLADIPVSETWAVLEKLVKKGKVRSIGVSNFTKDKIEDLLKTAEIPPAVNQIEAHPYLQQADLHKYLKEKDILSVAYSPLGNNIYEAPRVVDDSGVKEIANKLGKDPAALLISWAVQRGTSVLPKSVTPSRIESNFQDFIIPDAEFEALNQLDRNQRYNYPFRWGIDVFGELGAEEAERRAEEHAAKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2B9</accession>
    <name>A0A5N6U2B9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_127887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2B9"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000100">
        <property type="entry name" value="3'-5' exonuclease/helicase (Wrn), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="42"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="277" mass="31315" checksum="6979EC94DE97DB2C" modified="2020-04-22" version="1">MLEHIKATTDTPTIITTQSNNPAQTTPKYWSHRLPKTPNITVHYCKTLASTEEIAQKFLQDKVLGLDLEWKANAPASDGILSNVSMIQLANESRIALFHLALFKPARGRQHLVSPTLKRIIESPDITKVGVSIKADCTRLRKFLNIHARAIFELSHLYRLVKYCRSEPKNVNKRLVSLTQQVEEYFGLPLAKDEDVRCGDWTTSLAYSQVHYAAADPYACYRLFHAMNEKRLALEPVPPLPAHAELDLPIRIVCENPVVESDVKIETHVSRGDRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2D2</accession>
    <name>A0A5N6U2D2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sas10/Utp3/C1D family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_53084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2D2"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="375" mass="41506" checksum="BEA7A06435AC3EF0" modified="2020-04-22" version="1">MAAATQNPEASSLPDISTLLESITGCLTTAVSSLPKDQRNAPSDVSIEPPQDGISLLDTKSDLLLSYMHNLVFLMLFQLRGLSKDQTEESTSNQSLRDELVQKLVEMRVYLDRGVRPLEARLKYQVDKVIKAAEDAERAERTAANVKAAEAEQSGSEDESASDEEGSEGEGDDIDEMAFRPNVSAFTKKAEPEARTAKSDNKASSDGIYRPPRIMPTALPTTERRERKDRGPRKSNVIDEFVNSEMSSAPMAEPSIGSTIVRGGRHTKSKKEREHEAERTAYEETNFTRLAKESKKDLAKRGQQRGDSTFGGEEWRGLTEGADRISRLTRKAKGSGGALDRSRKRKNTEDGPRGDGADVGSIFEKRRKKIEGWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U2E0_ASPAV</name>
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        <name evidence="2" type="ORF">BDV25DRAFT_150473</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="90"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="34810" checksum="1ADC4832653A57A1" modified="2020-04-22" version="1">MHPPTTLQTFLTTTLGLTQPPALTRHTSIEGDDHMIYSLSNTPHILRVTKPRRNRVLTGQQMQAFDIALRRLIRDEYRGRGLSENLIPVSIASQVLDEEGVYAASLETRMHGTGLHIARATEETVAGFVDLLSILKGIQVDDLERKLGLEGGIPRIPFPDLQELRISALQAWDRLYRNNQLGDCAFGTGNIHSLLETKTDFVSALPCPSRAGSVLIHNDIKGEHVLVDECGRVTGFLDWADAGIGHVATDIAGLVLTVGVDMARRIARLVGYEEMVLEGVLLARCECVLRLDWRLNGEDGVSPVKLLREQLVLAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2H3</accession>
    <name>A0A5N6U2H3_ASPAV</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2H3"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="92" mass="9848" checksum="131C93C8B9136FCB" modified="2020-04-22" version="1">MPIAWTAEADAKLLVAIISTSKMKIDLKAVAAFMGPECTVSSVQHRINRIKDKVKDPNAASSAEASPEKPRKRGRPARLAGEVPAPKKAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2J2</accession>
    <name>A0A5N6U2J2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA element modulatory factor 1 TATA binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_150404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2J2"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="738"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="750"/>
            <end position="850"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="157"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="853" mass="95049" checksum="AA5CAE2525E23301" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Y7</accession>
    <name>A0A5N6U2Y7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_50299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Y7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="110" mass="12580" checksum="153FCCE57CFAF529" modified="2020-04-22" version="1">MTRSLFILQHFFSCDHRSRGAGPQRAFAWCGCSWSMTFVLLHTLVLLYIGCLAFYRTQLHGYSDDSIGVRLVRVRATGEGNAPLPYNHNVRSRADRLLDDAQMVYVYFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U319</accession>
    <name>A0A5N6U319_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_44857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U319"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="36796" checksum="CF385CAB84788630" modified="2020-04-22" version="1">MDQHDAWLRNANRVVAGVGISINTSLLLLRVYTKWHILRKLWWDDLFLAIAWAFSIGTQAIIFYGFAHAGYGVHIQYLSPATLKIYGKCIFAASIIYVPALAFAKLALLVLYYKLLHATHRLWVYTIYTVAGIITGYSIALDLALIFGCSPLEKSWNLAITEGSCISQTGVYLATAVTNTVSDVVLILIPIPIILTLRLPFVQKLGVACVFGIGCLTIVTSIVRLATLMPLVTSKDQTRQISLAGLFINIEANFIIICNSLPYLRHFLRHHAPRWIGDSLSSRRKSCSADSPGRVRKPGLTQLHDDIERAINQVEGVDSVEGRSEMSRAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3J4</accession>
    <name>A0A5N6U3J4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3J4"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="345" mass="40311" checksum="B81A53E26290D2FD" modified="2020-04-22" version="1">MPASLLDLPSELINHIIHLVLIYEDTPRPCPEPPYEYHVSWYRDSHDCLTQNAFGPKHVKYWKGQERRHKRWFSNPLALLLVNRRISQMTRWRLDRLPRSCALDVMLLGETYLLPTWISLPAPCRQIEDLTATIRIVGNSLTLNGRQHRFYPGEEGSPPLILWSFYYLLERFLEVGPLAEHRQPEPRPRLKRMPFTINRLTLNCVSCPQKYKVAPPDMSIWTWMEGSNSDTEPAGRYEGVLFLLMRPDWLARLINEYIGYLLGMDSDMALYGAMLYEYVGSIRVCIDGEVLKEYHLDRRLKDLNYTSLGDVHGDSWRQTRWLPPFAQWKKRVGCARARAGLPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3K8</accession>
    <name>A0A5N6U3K8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_38800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3K8"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025012204" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="218" mass="23763" checksum="2E6DA648049C6AD7" modified="2020-04-22" version="1">MNALLLFSVLSGALSLPLASVQDTTTQCTNPCNGVESTNHPSSLCGNKFLGPAVFTAPSDPDWSDMFAGYDPLAQLCPTSFLKQWTTGSAYIYPPDDGALLDSAQKPVITEYTLQEGYELDRFGSQYGGYLAPRGTPFAWRSIPPGNLNPHANSTQYNYWVWRVKVPFNVTGGPIAPWFGQPGFGLQFYYEAGLGELESQGFIELVESRSCPCVAHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Y9</accession>
    <name>A0A5N6U3Y9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Y9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="51" mass="5819" checksum="8FF85ADC7DDEBCF4" modified="2020-04-22" version="1">MNLSFTAFNDGNAWGSWFFRPSFCVRALLFLGLVVMGFMTLTHGVGPWYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4H5</accession>
    <name>A0A5N6U4H5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_149243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4H5"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="304" mass="33211" checksum="78372384A403465A" modified="2020-04-22" version="1">MATPTQKPLPFQYQFAAGAVAGVSEILVMYPLDVVKTRVQLQQGTAAAGEEYYNGMLDCMRKIVRNEGASRLYRGISAPILMEAPKRATKFAANDSWGSFYRNLFGVKEQNQSLAILTGATAGATESFVVVPFELVKIRLQDRASAGKYNGMLDVVKKIVASEGPLALYNGLESTLWRHILWNAGYFGCIFQVRAQLPKAEPGNKTQQTRNDIIAGTIGGTMGTILNTPMDVVKSRIQNSPKVAGQTPKYNWAWPAVGTVMKEEGFGALYKGFIPKVLRLGPGGGILLVVFTGVMDFFRKMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5F2</accession>
    <name>A0A5N6U5F2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_14507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5F2"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="39992" checksum="C3340CBA0813CEFC" modified="2020-04-22" version="1">MGRRRQLALSKSIQLALFRDPRAFRMSLLGRILAFFSIFYIKLIRYKAQIFRKLRNEIWDIPEEDYRACFLSEEDKTLPLLPKGDLGFSGSTFFSTSDSAFLVKSLPRHFEHSFFREDLLQPYAEYMSTHPESITVWITDYVYAPYQSLGTIFQTTPAHHIIMENMLCGKEEDPDADRWETYDLKPVDYFFPERDLLPDPFVSQETLSRLADEFPDKIRLARADYEDFKQTIQSDTEFLQSANAVDYSLFLVRFPASSSPSVIGKQNKWRVGFPSTDGKWKYRAVLLDFFWAKHKLHAQAMTGVIQTFNVIGRQGPMTITTTADEYRQKFLALIDSIMEVHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5H0</accession>
    <name>A0A5N6U5H0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5H0"/>
    <dbReference type="OrthoDB" id="4380184at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024820425" evidence="2">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="196" mass="21818" checksum="01B5FE5A0BD9173B" modified="2020-04-22" version="1">MYFSGLLATLALAPAVYGYGIAQVQVNAHDDCPIGHEAQHTVKKEMPAKVFPTKDSCPKVKVLKGFDIDTYSFSVEPITPDTFETCHGLAIYANEECVGVPDFVVPFHPRKNHAQSPCLPEIAFEKYVSLTLLCEEGHHRSAKEIAEGKAHEGTEHHDEDEHEEDHDEEEHVEHEPKQQAQDHTQHNSSPLGSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5L0</accession>
    <name>A0A5N6U5L0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_149251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5L0"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="240" mass="25783" checksum="776EC112D25B851F" modified="2020-04-22" version="1">MSAKTIIVTGASRGIGLAVAKYLLTASHNVVVVARSVEPLQKLKEQYTKQVEVLNGDLADVSMGQKAVDLALKSFGRLDGMVLNHGILGQVSKSAEADVEQWKHGFDVNFMSFVAFVTAGLPAIREVKGKLVFTSSGASTTPYPGWGLYGATKAAMNHLALTLGAEEPDVATFSIQPGVVDTEMQRELREDHATSLVPMMHSKFTTLHKEGKLLKPEQPGHVMAKLVLDGPKDLSGKYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5L8</accession>
    <name>A0A5N6U5L8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_148342</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5L8"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000005">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="13"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8153937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="353" mass="39799" checksum="199C8F879CBA5513" modified="2020-04-22" version="1">MAPDNASSHAKPPVDRNVKHVVLGDLLFQTWYQSIYPDDLVSKDTDRLYVCRWCFRYSCDVDTYAKHTRICQHRTTPPGTKVYDHGGYAVWEVDGDDNKLFAQNLSLFAKLFLDHKSVFFDVASFLYYLLTFTDPDNPDNYHTLGFFSKEKLSWDANNLACILIFPPYQHKQLGKLLMGVSYKLSDWEKDGGLIGGPEKPLSEMGQKSYNRFWQERIARYLLSHEVKPADTEESAQPKQKASKGARNSHPHEVMTAQDIGLATGMLTEDVITALKGMGVVEPTTPSKRRKVDQQPGESGPGTTVIIRKSDVLEWAKAHHLTLQDPVRDEGFLGRWAPAESLEIGGSGSDENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5P3</accession>
    <name>A0A5N6U5P3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5P3"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="293" mass="31604" checksum="0872F283B882EDF8" modified="2020-04-22" version="1">MKQADVASAESNHVVCIGGGAGAEIVALAAAWRDLMDEERISAGIAGVSLDESANTEQPSPDAVSESKSNPGLSVTTVDIADWSSVVHRLSTTIRSPAVPGSKSHPTPLLGLGKGNPAEDKNGFNVRFERSDVLTVPDDELKRLLHLETADKGSSPNATVMVTLMFTLNELFSTSMAKTTGFLLRTTDLLQPGTLLVVIDSPGSYSTLKLGKSKGAEGEASPAVQERQYPMKFLLNHTLLTVAEGKWESIYSQDSRWWRRDAARLGYDVGEGAGLEDMRYRVHIYRRLATSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5V9</accession>
    <name>A0A5N6U5V9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_167980</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5V9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="512"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="690"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8153962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122278" checksum="94D0D48D3C890C1C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U614</accession>
    <name>A0A5N6U614_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_167747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="62"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="389"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="725"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8154046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1293" mass="141968" checksum="18E5A5E7374DD7D5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U684</accession>
    <name>A0A5N6U684_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_126766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U684"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="255" mass="29313" checksum="49AA651DA81D4398" modified="2020-04-22" version="1">MSNPCNEDTIDDDRPNHIEETTDAQRNRSPSPDGSIALTFERRYYHCDSLFIKRNLRPSEYRMTQRGTLHVPRLGKERLQNEAECLRFIRRTTDIPVPTVYGAFEINDSFYLITEYIQGISMASLSEEQKRTVGLEIRQHLDTMHAIKSNTIGGPSGIVIPPYRAMRASANDDWPARSSNTTEYVFCHNDLSQQNIIVDPDTLRIRAIIDWEYSGFFPEYFDSPFYERLGPSVALEGENDDVKSLLKFLCISTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6A8</accession>
    <name>A0A5N6U6A8_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6A8"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="317"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="706" mass="79814" checksum="176FA50361554265" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6C2</accession>
    <name>A0A5N6U6C2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6C2"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025006478" evidence="1">
        <location>
            <begin position="20"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="232"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="682" mass="74465" checksum="94DCE1D1E24EE9E5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6P1</accession>
    <name>A0A5N6U6P1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6P1"/>
    <dbReference type="OrthoDB" id="4177946at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="176" mass="20614" checksum="9255716BF67DC9BC" modified="2020-04-22" version="1">MAAPYISIPIIDEFVRFVEEDSQYEDSVKAMALTILSHYFQAMSGYSVISEAYRNNGIPDFVIVRIQRRFPGDRSIVDHTMVEAKKTTDSLNESMEQLEGYLENANTEFGRCYGLLVRGPYFMFYEYHKQFPINDRYVPWGPPNQPHQNTFHARHDSATIDWMLRHMEQNPLPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Q2</accession>
    <name>A0A5N6U6Q2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Emopamil binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_127001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Q2"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="61"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8153801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="231" mass="26520" checksum="20F5BC84CCD8BB5E" modified="2020-04-22" version="1">MANMTSMISHQYFPPTILLPHYAANETSVLSLIGQFGVLWVAVLGSALILIRRVRPTASGSDQLAFVWMCLTGFIHLFFEAYFVVNYAGLAGSQELFGQLWKEYSLSDSRYLTSDAFLVSMEAVTAFCWGPLAFFIAYCIAVQHPARYALQLVISLGQVYGDVLYYATSLFDLYVHNVEFCRPEKYYFWFYYFFMNFIWLFIGSYYVKQSVTEITKAFKKISQLQASEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U714</accession>
    <name>A0A5N6U714_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U714"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="33089" checksum="105C5DC0401657BF" modified="2020-04-22" version="1">MSKYNTAPIQQSEANTPALTPVHFFSHGSTMMLGEESTSADYWKQCGDEALKCGIKGVIMMGAHWDCIGDQIQVATNPNPGKSPVAYVHPSKYIDYKLVPDLETSQRCIDLLAEAGYNVTGNPTFDWIHDTYLILIRMFPNGCPPTTLISMNARYDPHYHMKVGSTLRGLRKENYLLIGTGGAVHNLYRNRWAPMLRFRDTFAQDSPPESWALEFRQAVEDVLTKTSGPQLRRAMTRLMKHPEYRDAHATDDHFMAAMFVAGAAGDFEDVGAPAVLAAETWELTNMCNSQFTVGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U742</accession>
    <name>A0A5N6U742_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U742"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12337" checksum="88C707B81C6AE7E9" modified="2020-04-22" version="1">MGWFNEDSNEAEAHQQLRDFDGSEEHKAKFSHELIAGAASYEAMKAYEEHCEKNGKPDDHAKAKEILAGFAGAFIDREFESKGLDFIDREKAKYHAHQQLEEASSRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7A1</accession>
    <name>A0A5N6U7A1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_109850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7A1"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8154498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="197" mass="21947" checksum="7903B2B7D00D08F8" modified="2020-04-22" version="1">MFLQSVSRAAARSSAMPTTAIRSYRVVPGPMACLNARPQPVQKSIAPQQTRAASEHAISNPTLAGIEKRWEAMPPQEQAELWMQLRDRMKVDWHQMTLQEKKAAYWIAFGPHGPRAQAPKGEGLRIFLKVAQLTAASVAVFYVIHLFAKPQPKTMSKEWQEASNEYAKAEKINPLYGISAEGYEGKGFVQSPPLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8F4</accession>
    <name>A0A5N6U8F4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8F4"/>
    <dbReference type="OrthoDB" id="4461787at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14059" checksum="4B3D9F129D77858D" modified="2020-04-22" version="1">MSQRKLKHTPHLRATCKRKDGLATEKTTLLELNLCLGWNKKTETLYRQMNGQGLARGACWGCRYQALGGSGPRFGCYCAEVSNPVEVPGSDEEGAWVQFDLDSAVDVSNNGRLKCRTPQVGTKNKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9R4</accession>
    <name>A0A5N6U9R4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_167736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9R4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8155337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="508" mass="57865" checksum="0A5018BFA426C6AA" modified="2020-04-22" version="1">MPQAESARSNPMCCQLLLTQDTANVIIHKSCLLVVYRLFFHPLSHYPGPKLAAITNWYPAFLAWRGDLHLKNLEWHEKYGDIVRSAPNTLYFNDSHAMVSDIYSTRANVCKVDAWAIYSASRRSPNTLSVVDKDIHAFKRRTLATAFSDRARLLSEDMDKKAGNWSPGINMVAINNWLIFDLIGDIIYGRSFQMLDSPSKRWIPPIYIKMSRRGMTPKIYKCKLDQIFLAPMYKDIWSAGTWVRERVKDRMDMGESVEEKDLFSIMAEAKDKKRNREYSLKDIWTESMLLLAAGTDTTSTTMSALFFYLCHDLDALSRVTGEVRAIFDNEDEICAGPKLNACQFLQACVNEAMRLVPGVPNASPRRVLAGGQFVDGKHIPEGTTVASSLYVLFRKAEYFKNPDDFWPQRWIVAPETGVIEESVNLAKKVFCPFSIGPRSCIGWKLAWIELNWALARTVFLYDMRLAPGAQCCLDNKVGKKCHFNFKSFSIATPVSELVVQFRKRKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9W5</accession>
    <name>A0A5N6U9W5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_125946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9W5"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="292"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8155219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="43223" checksum="58428B4F4D91B9F8" modified="2020-04-22" version="1">MASPVPRGLRQVLQKSPSDIVILSSLRTPVTRAKKGGFKDAYPEELLANVLKATLEANPKLDPALIDDVAIGSVLQELGGAKAGRMAQIHAGFPNQVPFHTINRQCSSGLAAITTIANGIRAGAINVGIGGGMESMTRNYGSRAIPTVLWPELKESHSQDSRDCIMPMGITSENVASRYGISRADQDVFAADSHKKATAAQNAGLFDSEIIPVKTLSYDPENPDAPPQEITVTKDDGIRPNISVEKMASLKPAFAADGSSTAGNSSQVSDGAAAALLMRRSTATELGLASSIRARWVGTAVAGCAPDEMGVGPAVAIPKLLSNLEMDVKDVNIWEINEAFASQALYCVRKLGIDEAKVNPKGGAIAIGHPLGATGARQLATLLPELERTGQEVGVVSMCIGTGMGMAGMFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD29</accession>
    <name>A0A5N6TD29_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_167426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742665">
        <property type="protein sequence ID" value="KAE8144202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD29"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="174" mass="17987" checksum="D403C1EF0BE109AC" modified="2020-04-22" version="1">MERLRNATTSIFNSGQTVAREHTTALIASGTGLALATAPITGPAILGAVGFSAAGPVAASFAAAWQSSIGVVQAGSLFATLQGAAMGGAAAGTFTTASNIGIGMVGSVAVGKQWTYIKKRLWMKHDSEHFEEAGYYDESQPAEDNEDVANNPQMPDIDDLLGTEFAKFLAIDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD52</accession>
    <name>A0A5N6TD52_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML743189">
        <property type="protein sequence ID" value="KAE8144089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD52"/>
    <dbReference type="OrthoDB" id="10506793at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="27599" checksum="962454A6CEB5E081" modified="2020-04-22" version="1" fragment="single">MIADDPRDAGTTTALTSAGTSDSPTITTTIDPSVSPSRTPGATTSSSSSLQQPHTYVPPVPKLPQGRFSFEYQLPLRRRTLASHTSSLIDTPSVPNPTPSSHRTFMYDRPRRSIPSFSLSHGRPPKESVSLPPSPRFTLDRDPESALAPDADSTVKTLSPNATKRRKDSFYAQQTPPNVKRRMPSSATIYTQEGILGDRSRIVNGVDRHTLEVSGRTSVADDTRSKNEDIFLNIARSDAGRRESLGRSELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDH5</accession>
    <name>A0A5N6TDH5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742576">
        <property type="protein sequence ID" value="KAE8144306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDH5"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024945685" evidence="1">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="31364" checksum="665576171D60A3B9" modified="2020-04-22" version="1">MTGLHRLLPTVALVLTQCILPTIAVPLTAGEDTQTFLTDTSASSPYHPEQDADTIHTENAEAQRAPSWFTSTLMARRLLALSTTGVASTIFPQDPPENARTPPEVAGQSISLKEYISDCDAALPADISEGGNGDPTFLALHVATTFRNTAAGSNISLSLDWWDHLNDTEPLFPGFPLSPAGLPRVTLFGHIEEFPAPLSRETESALQACYLDAHPDARVWLPGRPHSPHASFWARMVVTQVYWIGGFGGFQQIGWMNVSEWKGVRREASLPGIGDGRGWADVRLPGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEB8</accession>
    <name>A0A5N6TEB8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_95351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742524">
        <property type="protein sequence ID" value="KAE8144441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEB8"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33667" checksum="8BCE4AB7AFC0F008" modified="2020-04-22" version="1">MAPQKPVTGVPRSILCSSARTTILPPQNIVLLTRQRQNTLRLLSRNSAGRQRQAWAFSPHPSTFVASRERTVSWPASRQSATTRPALESTGGPIRYNGVYVAAFNLARRAFHASAPQQRDHYFDTLKFVQRLKSEGFSEEQAVAIMQVLNNVIQESIQNLTRTMVLREDTERSTYTQKVDFAKLRSELLNADSTEAQLTRSSHEKIAADLAKLNSRLRDEIGRTQASVRLDLNLEKGRIREEANGQEMRIKETETRIEQEVAGLRERVEAVKFSTLQWLMGVCTGTAALILGAWRLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEI1</accession>
    <name>A0A5N6TEI1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_166210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="ML742450">
        <property type="protein sequence ID" value="KAE8144707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEI1"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="95"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8144707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="294" mass="32820" checksum="2272E456F7F0865E" modified="2020-04-22" version="1">MTDPGVHSQMHPQSNGANLHTTQYPSTPTPKQDDNLNQSTQPTLSATIAQCHQKVQTFLNESHAPDSLLGKVQRQTRISLDVAATALSRYTLPELALSYNGGKDCLVLLVLFLASLHPHLSPKEEGKGEGGLKSIPAIYALPPDPFPAVEEFVQWSSNAYHLDIIKYTTEPPKTTIKSSFADYLALNPAVKAIFVGTRRTDPHGAKLTHFDRTDHGWPDFVRIHPVIDWHYAEIWAFIRQLGLEYCPLYDQGYTSLGGQTDTHPNPKLRVGAVQEDYRPAYELTEDLEERLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEX8</accession>
    <name>A0A5N6TEX8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">BDV25DRAFT_165919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742424">
        <property type="protein sequence ID" value="KAE8144856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEX8"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="247" mass="26653" checksum="E8DC6A47DCE1AB52" modified="2020-04-22" version="1">MAVRAQFENSNEVGVFSRLTNSYALVAIGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNRKGLLVPTTTTDQELQHLRNTLPDSVRIQRIEERLSALGNVICCNDHVALIHPDLERETEEIIADVLGVEVFRQTIADNVLTGSYMALSNQGGIVHPKTSIRDQDELSSLLQVPLVAGSVNRGSAVVGAGMVVNDWLAVTGLDTTATELSVIESVFRLGEMGPRGVGMGNTNKESIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEY8</accession>
    <name>A0A5N6TEY8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_165912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="ML742423">
        <property type="protein sequence ID" value="KAE8144867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEY8"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="292" mass="32314" checksum="FFC677EC11EF7EEE" modified="2020-04-22" version="1">MSFLSYVTSGISSFVVVTVSLFALGQKVPRAAFGARCLAAYGSLLFCATYGVVASIVLRLVGYGRVSQWATARSFKWVMRYTTGVRFDIVEGQEHLATRPAVFIGNHQSELDVLMLGYIFPPYCSVTAKKSLRHIPFLGWFMSLSRTVFIDRANRETAVKAFDSAADEMRNHRQSVFIFPEGTRSYSDKPELLPFKKGAFHLAVKAGVPIVPIVSENYSHVLSPRHWRFNAGTIQVKVLPPISTEGLTPADVDNLTKSTRESMLKTLLEMSENTQDKVDDTVASSTSTAVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFF5</accession>
    <name>A0A5N6TFF5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_165931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742425">
        <property type="protein sequence ID" value="KAE8144849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFF5"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8144849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="380" mass="41892" checksum="0BB0C7EF2872EC81" modified="2020-04-22" version="1">MTTPSIRIPFTGLLPPPIIVPPSARTVHGAIDALLSFLTSAPSPYLRGVDVGRHSQSVLLTGAGISVASGLSDYRGENGTYITNKTYRPIYYHEFLTQHEFRKRYWARSFVGWPGLLKAKPNTTHRAIRDLNTKGYISSVITQNVDSFHTTTHPESPIVELHGYLRSVVCTSCRNQFSRNKFQKSLENLNPAWAEFLAKVVDSGALDTENPEEQRRKGLKLNPDGDVDLAKAPYSTFRYPPCPTCLEKPPRLQDGTLARVEVEKDGAWLPGSTAGILKPAVIMFGENIDPAVKTAAEEAIDDAGRLLILGSSLATFSAWRLVERAHRRGMPIGIINIGGVRNEPILFGQHDPDTPHFRCSLNSDLILPPVVAQIPSLNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGX4</accession>
    <name>A0A5N6TGX4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_69772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742340">
        <property type="protein sequence ID" value="KAE8145500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGX4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="89" mass="10052" checksum="1D34B13A6825B8BB" modified="2020-04-22" version="1">MRNVNLRRVLGYFHFSSVRYLVWPKVNINSLGGSCTKKFSNLVSQPFMSPLSTTRRNGISYACIVLLLSLSLSLSLSFPQVTHPVEQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH37</accession>
    <name>A0A5N6TH37_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_133674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742333">
        <property type="protein sequence ID" value="KAE8145560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH37"/>
    <dbReference type="OrthoDB" id="4230925at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="55" mass="6040" checksum="14D16A3381F7AF1F" modified="2020-04-22" version="1">MANQCPGHVFAIVQATNGNILTWRCSDCTSGPFVAIWRCKICNHCRCNSCHTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THE0</accession>
    <name>A0A5N6THE0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_164006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742318">
        <property type="protein sequence ID" value="KAE8145727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THE0"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <location>
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        </location>
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            <begin position="34"/>
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        </location>
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            <end position="378"/>
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            <dbReference type="EMBL" id="KAE8145727.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="708" mass="76184" checksum="CC0D260195E6FD81" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus avenaceus</name>
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            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the ATP12 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40694" checksum="088B8813314C02B1" modified="2020-04-22" version="1">MPNLPAFTAFSRRVVWNITRHDIALLRYLHSTSPKAAIAHPVTAHGPPPKVPSPAPEFCERNERQHVNAGSQVDSNSLPAKPSPLKKRFWKNTDIRQNPGGNHSVLLDTRPVRTLTKEVLSLPSTKPHLAHLIALEWDVMTSAQQALKNHMIPLTSLAARAADIVREDVNGDMATRVQIVNTAMRYLETDTLLCWVPEKNIHDPGEVNENGQSPESLRKAQERVAKDIISFLSTKVWPGIEIKPILDTESILPVSQTKATRDIIEQWVSNLQAHDLAALERGVLASKSLLVAVRLVSEWSENFRYIQRSGLTKFGIEEAVEASSLEVKWQTDMWGEVEDTHDVDKEDLKRQLGSVIVLVSGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIS5</accession>
    <name>A0A5N6TIS5_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_162877</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742276">
        <property type="protein sequence ID" value="KAE8146246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIS5"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </feature>
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    </feature>
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</entry>
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        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742250">
        <property type="protein sequence ID" value="KAE8146636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJU9"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="574" mass="64289" checksum="95AD9816E0D7C830" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJV0</accession>
    <name>A0A5N6TJV0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742252">
        <property type="protein sequence ID" value="KAE8146612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJV0"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="334" mass="37750" checksum="CC676A682EDAF0D6" modified="2020-04-22" version="1">MHFTNILQRAPPLSRTRQLKQLSGQGGPASLGEQLCNQQQQVKGLQSTLQKIATLAQEATKPPNALSAGSQEQDQPSSDERHPQNSIVHTENRNPMSEGGPFPIPGLSMPVIPLCNDEVWGTDLRCGESERNFLQVLGHAFSIVEGFPLTLGILANDPVADDDFCIRAVMQGWGAAGKRAPADPAWTLLQAVDQGLFYRADPVTRLTLLRLMRSMILQRMDPSSQRRSVPEYMRKSQLQSTVPHAYFLDFFPWPEFRDYWIARGLDYASEMCASSFARSIYFKWPFEFRDAFMRDVFSDTFSFSHEFNTRYSEIGSWHLVIPAEHVQHAQALPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK64</accession>
    <name>A0A5N6TK64_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742259">
        <property type="protein sequence ID" value="KAE8146481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK64"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="37708" checksum="DA10267DDB611583" modified="2020-04-22" version="1">MSMRQAKTWVLDGQTGPERLKFEDVTIPELGENDILVKMRATSLNFRDLNIVKGSYRNATKERLTPGSDGAGIVESVGPKVTAFTPGDKVVTYFVKGYSDTEPLTFAAIYKNGVGTSVDGSLREYGVFHESTLMHMPNQLSFLEASTLTCSGLTAWNALFGLAGLTPKPGDFVLVQGSGGVSIAALQFAVAAGASVIATTSSNEKAEKLKLLGASHVVNYKKIPDWGVAVKNLTPDQKGAHFVVDVGGVSTIGQSVKAIRPMGVLSITGVLGNNSDEQVPNIMDCLTYNCVARGVLVGTREQFRAMTHFIEDKAIKPVIDERVFHLEELKEAFEYIGSQLHFSKVCIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKG6</accession>
    <name>A0A5N6TKG6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_162183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKG6"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024801408" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="177"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="658" mass="71839" checksum="408344353621CB36" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKV9</accession>
    <name>A0A5N6TKV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_42954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742232">
        <property type="protein sequence ID" value="KAE8146982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKV9"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="43154" checksum="137FEE98D408DB7B" modified="2020-04-22" version="1">MGSYLNSLPLLNSTVAKWAYISLAAFANLPGKFNRTAFRAPWATTEISNEHLGQTLSYLNTTDFVAYDPRFFDIIGPNARVEHVQKLAFQSHEAPCYIKDTKQVFFAEWGPPGGERGIHSWQYLLDTETNTLRNITTDPPTYNAHGCVYYNHSLYVVTDGYSDVQSGELVRIDPFSHKKETILNNFLVQPFNGFNDLEIDQDGNFWLTDSNAAWGREMIQFTRLTNPSIYFVEGSTLRTKVVHTTTGNTNGVAISPDGQTLYLPDTGVSEYRPKRTNPYGMRQLWAFDIAHSRSVLSNKRLLSNPISYFYDGVRVSRNGWIFCGAGDGVDVIDPESGFTLGTIRVGGGKNVAVNIAFGEHELWVVGQGGVWHVKGIRDRLDREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKW7</accession>
    <name>A0A5N6TKW7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_41695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8146994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKW7"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="380" mass="41873" checksum="BFF06AD87ED0FAAF" modified="2020-04-22" version="1">MHGLPNTFTGEDHPRHRSDASTNFNPLNITRDTFQALLDCYPATVETVVRRKATNRLIFGASARAKKVKALKRVAELEDQLPELDEGQKEQIDSEAKAYLTLDKYRYDELPARAKERAAKEGSRYLEKDEVVQIVEWKLKHGVFRPALLGMVKGNQDKSIRKATSDAFAAISSAAGSPGPEFGTFKYPQASLDGLVKGLRGIGVATASLLLSVGTTSTGPGRDVPFYSDDTYLWLCVKQFPNTEAQAVSDADKEGMHDAPKRASVRRRASDEPKLKYNASEYRQLWDAVNELRSRLDGPSSAAKTDNLAISCTDIEKVAFVLRHIDVSGYAKGYASQDRQAKPTDGGTVGTTATKRRRHDEPNSSNTRRKTKSTAGATYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL12</accession>
    <name>A0A5N6TL12_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aromatic amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_132417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL12"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
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    </dbReference>
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        <property type="entry name" value="UBC-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
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        <location>
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            <end position="726"/>
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            <begin position="727"/>
            <end position="746"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="919" mass="100935" checksum="ABC588CAD2146E41" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLN2</accession>
    <name>A0A5N6TLN2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_36282</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8147257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="412" mass="44865" checksum="78223F712FE4398F" modified="2020-04-22" version="1">MRGLRLLACSYPLVGSTWAQTGMTKPISEACGPSLVCVNRYANVLPYHFYRNVTTMGNISSFSDTRVANGSMLEEVKLADFLVFDKQRGFEILGPNPSYEFMFTVSDAVHEAPVYVASQNKLYLSQLAPPPGYLPQLVVDLNLDPPTLTEYLSDPPVYAPNGGTFHNGKIVWGASGGNRSIGGSEQRVSLRTLDPKTNKSVTLINNYFGYYFNTIDDLAVHPSTGDIWFTDPQYSWFNGLTDTAPQLPSASYRYNVSSGAIFVIDDSIGQPNGIAFNPEGSIVYMTDTAAVNAPIDPKFGHPGSTFNTTQRRTVYAFDVSEDGTSAYNKRPVYMASGFVPDGLKVAANGYIVAGVGRGVDILDPSGQLILTIQTNYTVQNFAWTGPELKTLWLMGNGGISKVEWALAGQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLT9</accession>
    <name>A0A5N6TLT9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_160666</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742214">
        <property type="protein sequence ID" value="KAE8147308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLT9"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="326" mass="35352" checksum="D722B29AE05620E1" modified="2020-04-22" version="1">MGESNGTEQQESSFPSGTIAKLTCDILNNTFYNIIHDIVSKVHRDEKMARMRSAVTIARQKAEDEAARRREETGAKPTALKPGEDFEELKDIHVETDGAVFDEGKVFLKGNPLQTTKEIICPDCRLPRLLYPVTGVGARPPPDPYREYCQKQPMISKPGHDVHGNPFATDKLNPKKKKQTNTSNTPASSPPTTPDSSFKQAAPEKVSFPTVKCPNCPRYFVVTRVAQHLDRCLGLSGRQVNRNKTPMENGTSTPSSAPAKRPLDEDTPSTLPKKKKLGAPKKLSGKKPPPAPSSKLKNGVTPDMAAAADAAAAGDGDIKSETNGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN91</accession>
    <name>A0A5N6TN91_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_30248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742200">
        <property type="protein sequence ID" value="KAE8147581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN91"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001278">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="360" mass="38849" checksum="E03B3D85F0455C40" modified="2020-04-22" version="1">MTMVIENQNRQYGGMGFDNVYQHNMPHHNTPQFTDPWTAAHTTSHSTPPVYATSMGSSQILNHPKQEEVSRPSPLSMPYSSIPVSAPSMVTGSTYSTTPATSYPAPEVMGLHHDMPRTSFEQAPAYTTASSMSSFAPASYAPLSYTSPLHGDSRRISHADPRAGQSQASSAPTFGDALDASRGMVALSQDLTPRNIYGPRNTRGSADSYGFPSAHSSGSSISSGGSYPYYSASVGSVESSVTDYSSTTSESYENGHLSRTLPRPSNLLTGSAPPGPQSMMSQFSSKMPSNTQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFACDVEGCGRHFSVVSNLRRHKKVHKGEKEGVSGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNN5</accession>
    <name>A0A5N6TNN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_159309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNN5"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.40:FF:000002">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000005">
        <property type="entry name" value="Mitochondrial ATP-dependent RNA helicase Suv3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="346"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="716"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="761" mass="85390" checksum="E97035EF94FA1DA9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPT6</accession>
    <name>A0A5N6TPT6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_168540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPT6"/>
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    <sequence length="507" mass="56703" checksum="AA8F3F50D7DCE141" modified="2020-04-22" version="1">MAPRSGSHARVSRSCGNCRPIKRRCDRRLPHCGQCIRMREPCPGYRDEWDLVFRNQTDHTIKRSKEIRAKRDNKATVARGVHSDPHPSAGFSPNPNEIGVNYFFHYFVTGCQSSSRGYLNYIPAVWTADGHHPTLVASIAAVGLVTLANTTRQPTLAKHARAKYTEAIEQVNLALASPTESIKDSTLMSVISLGLFEHVSNFVSWARHIQGAAAVVAARGKCQFATRAAILMFNQVRADMVAASMYSNQPFPAELEALQEEAAKYVDTTSVFWRLGVVATQCTKLLWVVKNNRAESSWLSLLEQANSLQRELDQIFVILSTKSPYTIFQKPGGNPAVFYRERFDLYTNIWAIRVWNNTRILQIKVCDAIRYILNHILVSDLNRITQVPLKQKLRDTMKMSSKLGEDMMATVPQVLGMVSSASETVPNIHGSFPTNGSAGYMMTWSLYTAAKSSVIDYEGRKWIVGRLQDFGHVGGITLALQLAEDIINFDRCENRESLILLSGPFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPY1</accession>
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        <recommendedName>
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        <name evidence="3" type="ORF">BDV25DRAFT_158428</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1535" mass="162699" checksum="E23E56D809D81D63" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_168389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37647" checksum="ED5B278B3E479894" modified="2020-04-22" version="1">MSLFQILALSRGFILHALQHPLDALLSFGPTLNEATFGLMGTTFDPTRDIGDLSGKVILVTGGNAGLGKETVLQLALHNPSRIYLAARDAVKAREAISSIQETLTSPVDIRHLSLDLSSFKSIREAVVKFCSNCDRLDLLILNAGTMGNPPQLTEEGFEIQFGTNHIGHFLFTKLLLPTLQRTATTTNRDRVSDVRVVTVSSAANLIAPPFEVMTSTSALLAAHTMKRYGASKAANILFASELARRCPDILSVSVHPGAVTSELYRYAPTIHPFAKVTLSVISGFFRSTRTGASNQLWVATTARDELTNGDYYVPIGVCGSTGYTKDADMARQLWEWTEEQISTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQL2</accession>
    <name>A0A5N6TQL2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UBX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_158041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQL2"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="510" mass="55426" checksum="21C9E60B30BF71DB" modified="2020-04-22" version="1">MSSHVVVLDSTARRATIKTTPGKYLTDVLQEACTKLGVDASQYGLKYKGKQVDLSLAFRLSGLTSGAKLELVQLSRSPSVVNVALQLPECESHGAPNGRLMDKFPSTTTLWLVLRKFEAGVAGSSLTRNLTARGVPVTGNGDGGAGRLFYEMPVVQIIGRELSTFTDLQKTLAQLGYNSGNVLLRLSFRRTDDPLEVAMVKIQEYFSSSDDTIPQNKEPSAPAEAMQAADQPNTPQEEESTQSTPDVPAPAPVMPEQPSETQTAPSPLPADSLEPTTVPSRSVTVFAPPANDTPQSAQTPFNENDYIPSVEHAQAHQRRLNIAHQNKRLPSDAEIAAKAAAEAEKLAAIKDVDVKVRLPDQSQVVAKFGQHDTGKSLYGFVRNCLAEPFAREKFIITQFPAPGPRTSSKGHQNVVPDSDQRLLIKDLNMAGRVMVNFSWDTSASSAARQARTDLLRPELRSKAQEHKVVQPPEVMDTSEDTVQPKSDRPDKPSGRKPGSLPKWLKLPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQN0</accession>
    <name>A0A5N6TQN0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_15633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742153">
        <property type="protein sequence ID" value="KAE8148610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQN0"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="556" mass="61833" checksum="4DCB1B1CB2AB8FF2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQT0</accession>
    <name>A0A5N6TQT0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lactonohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQT0"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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            <begin position="219"/>
            <end position="317"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="446" mass="49515" checksum="7B1C0FAC9D773821" modified="2020-04-22" version="1">MDLFNSTTLLINMKHIFAITVNTAIALGNGLQWHDDQHVILDSFHHSSKTAADSLVHKCIAPGVVCLENQAANLPYPFWRDSPNGTFVTNLADIKFQHGAKSTSWEQVRHADFVIFDEERGRKLLGESPSVDFVFPVNPWALHEAPVFVPGLNKIIFSELSPILEQFAIDLNVDPPTLSQFKADPPIYVPNGGFYHDGLIYYSTAGSSKKLKQRPGITTLDPWTNKSSTLLNNYYGLTFTDCDDVIVDPVTGFIWFTVPYYSWWLEVADTPPQLRSATYRFNPATGSTVVVNDEMRSPNGIAMSPDRRYIYITDTAAAGDSAPISLDIPSPGVMGILFNTTGLRTIYKFDLVDQGHAITNKRPIHYDAIGTVPDGLKVARNGWVVTATGNGLSVMDEYGDMIARVQTNFTVNNFVWSDANDYREVWMVGQGGVARVKWDLQGQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR26</accession>
    <name>A0A5N6TR26_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_12394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR26"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="115" mass="12933" checksum="014CCE8902B45848" modified="2020-04-22" version="1">MTPDRSVERPRAQPAASVNTLPRAHTTPHIKRSSSSRTPTTADPPDAEAAHKPHELNQETLQYNRQMKTAVTELLNDARVTRGSQGSRCLQNILMEAERDLKANRRESLNMHRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSB0</accession>
    <name>A0A5N6TSB0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_141015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSB0"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="515" mass="56249" checksum="8DF39DEAB929CDE2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSC8</accession>
    <name>A0A5N6TSC8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="4">2.7.1.108</ecNumber>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_167938</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="4"/>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ML742129">
        <property type="protein sequence ID" value="KAE8149263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000004">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1293"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1324"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1386"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1439"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1484"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1524"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1564"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="17">
        <location>
            <begin position="122"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="824"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="885"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1212"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8149263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1642" mass="179390" checksum="79E77518BCEC96E3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTB6</accession>
    <name>A0A5N6TTB6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-galactosidase</fullName>
            <ecNumber evidence="11">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_156014</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="11"/>
    <dbReference type="EMBL" id="ML742118">
        <property type="protein sequence ID" value="KAE8149602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTB6"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024961718" description="Alpha-galactosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="358"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8149602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="437" mass="47742" checksum="85AB687AA2C77E48" modified="2020-04-22" version="1">MASYLSATAVLSLLAQANALVRPDGVGRLPALGWNTWNAFNCDIDASKILTAAEQTISLGLKDAGYEYINIDDCWSVKSGRDPNTKRIIPDSTKFPDGISGIASQIHDLGLKVGIYSSAGTETCAGYPASLGYEKIDAETFAEWGIDYLKYDNCGVPSNWTDAYTDCVPDTTNGSNFPNGTCPDLTNPAPAEYDWSTSKTAKRFEAMRDALLNVDRTILYSLCEWGQADVNTWGNATGNSWRTTGDITPHWERIAEIANQNSFYITYADFWGYPDPDMLEVGNGNLTLEENRAHFALWAAMKSPLIIGTPLDSIKEEHVSILKNKYLLAFHQDPVVGRAASPYKWGYNPDWTFDPAHPAEYWSGASSALGGTLVLMLNSEGSKKTRTAVWSEVPGLGGNGYRVTDVWTGEDLGCVEKEYSVELQSHDVAALVVGESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTF1</accession>
    <name>A0A5N6TTF1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_3837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTF1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF142">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="482" mass="52273" checksum="7B61739FD0B60DCE" modified="2020-04-22" version="1">MREPKIASSASSGVTKTTRHVEFEGPEDPLNPLNWPLGKKVYMCAILGISTMIVAFASSVFAPTVPVMMQLYGISKEVATLGVSLYVYGFAFGPLVFAPFSELKGRYIPLVLCMFGFTVFSFATAVSKDVQSLFILRFFTGFFGSGPLALAGPAFADMFSPQQRGVPIVMFCLMVFIGPLAAPFTGGFIVMNQSLGWRWTAYIPGILGGAALVVMAFALEETYQPVVLTRKADHFRRETGDWSLHSEHEEMRMDIRAIFENNISLPLKLLVKEPIVLFMCIFGSFVYGLLYLFLTAYPYIFQITRGMNPGVGGLPYIGVIIGTLLGAVATGATQPWVLRKMKQNGGVMEPEWRLPVAVPGAVAFTGGLFWLGWSGYKGSIHWIVPTASGLFTGFGLLTMFLPSLAYLVECGGDKSASAIAAHTFLRSAAGGSFPLFATQMFDGLGVEWACTLLGCVGALLIPIPLLLYLFGARIRARSDFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU03</accession>
    <name>A0A5N6TU03_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_140674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU03"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="36110" checksum="AF320972F7948ACC" modified="2020-04-22" version="1">MPVLPKTYKAWVIPSVGAPLELQEVELKLPAAGEILVRVRACGVCFTDVAVQKSELGNNLFPRIPGHEIIGDIVAVGEGAQGLSLGQRIGGTWLGGHDNVCRSCRRGSQAGQPWKKGIAPGGPLHMNIDSPRRHLCTPDPAETHYLPISDDDWNSGVGCRLPYTVSAPTNNKMGKFARLAQASHLLARVMRHICDTQADSHFLDTEKGMLDLALRSLLTLTVAEEQQCGIAYCSPVAFVSSALLLLHSFHLGASPSVNKESASYCYREVTELTCKVTLPIARRLKELSSSDAHAPCPLLLDWMYRSVIAYNTVRETDTTVLLSGKRRSSAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU27</accession>
    <name>A0A5N6TU27_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_155949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
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        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GRX_GRXh_1_2_like"/>
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        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="102" mass="11030" checksum="D21A1E4F180AAD16" modified="2020-04-22" version="1">MSAAKTKAQTLINENPVVVFSKSYCPYCTASKKLLSDQGATFHALELDLEKDGSAIQDALQEITSQRTVPNIFIKQKHIGGNSDLQAIKGDLPRLLKDAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUF0</accession>
    <name>A0A5N6TUF0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_119369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742108">
        <property type="protein sequence ID" value="KAE8149920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="7">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="444" mass="49609" checksum="5C1C3628C285905E" modified="2020-04-22" version="1">MSLVQVLSVLASQDEQGNSLARRLAYTEGGPTMDIDPLPSAQRKGLIAVTVMAFLSFLATLALILFVTYRLVFWRSNYARYIGYNQYIVLIYNLVLADLQQSLAFLICLKWITENKIEASSAACFLQGFWLQIGDPSSGLFVLAIAIHTFLLVAMGHKLSHRVFVSGVVGLWIFVAVLVIIPLASHGRYVFIPSGAWCWISEEYEPIRLWTHYIWIFVAEFGTVCLYAIMWFQLRVRIKQSAILGSSHTESLKRLRRVIGYMVIYPIAYIVLSLPLAAGRMATAQGQTPSIAYFCVAGAVITSSGLVDVLLYTLTRKNLILESEPSRDRSYNRFASSKNRKTDHLTTITAAEGRQNRADISVLRTHRHREDDDEFGHTVREGSTDNIVQPTGMELVPLGKVYQHTTIEITSEPAFPAEGEASSDRSSKDSIGKGQDPGSRMWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUS0</accession>
    <name>A0A5N6TUS0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_140167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUS0"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="402"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="690" mass="77337" checksum="C84C24EF80E9D08D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUT8</accession>
    <name>A0A5N6TUT8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_116911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUT8"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="193" mass="20384" checksum="3D47D1EFD700434E" modified="2020-04-22" version="1">MSQINYRTINIDVLDPESSVNFPMESLLPATLPAPGTSSDAAGVASEVRQLLRSGDAEGALRHALDTAPLAGDDRAKEVHLATVIEVLQGIRQGEMLRVLEGVCGGSGGSERADCLMKYLYKGMAAPAQGNGAQSPRRGISPQSTGFSQIQPRNVGEGGSGQQMSVLLNWHEKLVEVAGTGSIVRVMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUZ8</accession>
    <name>A0A5N6TUZ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_154937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUZ8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="68" mass="7165" checksum="4F29880FE095D333" modified="2020-04-22" version="1">MTNSHQIADCKGGVVDVLLGGFEDLLVHSHAHIGYAKGMGCVIVVGAWLSVSFIIHGVCMEIEIGILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV50</accession>
    <name>A0A5N6TV50_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_154741</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV50"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="485"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8150243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="894" mass="100646" checksum="AA1871D9252F0F61" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV84</accession>
    <name>A0A5N6TV84_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_172278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV84"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35435" checksum="44316F4F38F4E9AC" modified="2020-04-22" version="1">MAINDSAAGETADLNSHEPSLTEAKNGYDVETADNRICVRQFSDRIMEWPEEDWSGISDPKQRRKLQNRLNQRVRRLRKRLDAKGLPNCETGVGGGRSHDDGNVAFSLAAIEQIHIFDPDSVRTKRILQQLEAFARTQYILGSPRTDMLLHLIQLNFSKALIENAEILGLTSEHLHYDAISPFNVNGPWQDRFGRSLPSTLQPTVIQRTVLHHPWLDLIPIAEMRDNLITAEDSYDETRLCLDMRGDTSINAGQTGVIVWRDPWDPSGWEVTELFARSWGWTLQGCWDLARSTNSWRTQRNERPLFRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWB2</accession>
    <name>A0A5N6TWB2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HotDog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_110509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWB2"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40293" checksum="BD9651D26EBCFBFB" modified="2020-04-22" version="1">MTLSPKAQRSMRLYPSFVRRGCSAMRRFSVYHAQRSASEPLASGIAASFLSRFQSLGPQTRTQLLDANQLQLLSLTLNRPSLFSDSPSLSNTSGSVPDGTPLPPGYHLVYFTPAFLENELGADGTDVSYNPETPFTRRMWAGGEVHWPRGVNGNPNPLRVGQKVQETTKVLSAQPKTVRKTGEEMIVVGVEKEFRNEHGVAVIDRRNWVFRKALSAPSTPHASNDAPVPSAPAFSSTASVARTYTRTLRQTAVTLFRFSALTFNPHKIHYSTPWAQKIEGHKDIVVHGPLNLISILDLWRDTRSTQGSDPALMLPENISYRATSPLFAEDEYRVVLDEEGDGVGRVQIFDPKGTVAMKAEIKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWJ9</accession>
    <name>A0A5N6TWJ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_153831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWJ9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="73" mass="8238" checksum="242D9BDDC7DE075D" modified="2020-04-22" version="1">MSLLTQIYETEDGSLRRKARLASVSSQIVEVIHIYNDCETRQGSISIVYNYVAIDFTVSNMNALFGIAYLTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX50</accession>
    <name>A0A5N6TX50_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonucleotide reductase inhibitor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_153590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX50"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="236" mass="25891" checksum="05F758308D3C74CD" modified="2020-04-22" version="1">MSSQTTDLSKRRRFQPPITTFFTAATGSDPTVCAPHLSHTHYSAATSSPTPAVPAKVQASLLSVGMRVRKSVAEGYKTQLSKSESSSSNSSSKPSLYSNNTPVVTCSTTYTELAPFCGTTKSGNEYQGKESRMDELVTDDGDAFSLPPSSQESVESVVPVSGHKRSYDSDEEEEDIGFADYAGTPWQRAGRAILTPKLGQQRRRFVPVRTQNSLDIDEFEEPTFLRRREEVDMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXA4</accession>
    <name>A0A5N6TXA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative importin 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_139538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXA4"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000560">
        <property type="entry name" value="Importin 13, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114027" checksum="843FE9C3D55DCCB6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXM5</accession>
    <name>A0A5N6TXM5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_139224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXM5"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="776" mass="87448" checksum="A07099662C49C5B3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY22</accession>
    <name>A0A5N6TY22_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_128982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY22"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31393" checksum="1D5ED536558A182E" modified="2020-04-22" version="1">MRAKSVKPSAYPPIPFHAIRAVGAISTLVVGIILAVFIYHLSQGSQKLPWAFLVLLITAVLSLLNYILTTVTHCFYGLSPRLSLVSNSICLLLWLISLGLLSYSMSKTITTTCNATYWATSTGILVCRIYKALFGFTVLANIAYIAAIALDVIVRRRQTRLGEYDPMASNPGLNDYKMHDRNSSVMSGSMGPYPGVDEHPAYRSNPDDVYKDVPAPGEYPAQRMPPPVYGSSTTFEQHHAGEEHDFSESAPAHRGGPRVRFSNPGYNGYSQPLEQSTHYDPAAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY23</accession>
    <name>A0A5N6TY23_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_152863</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY23"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="168"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="371"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8151288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="561" mass="60871" checksum="9EAC9CE36F22887E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY85</accession>
    <name>A0A5N6TY85_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_95747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY85"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="334" mass="36675" checksum="B99523DCCBA68225" modified="2020-04-22" version="1">MLEAIAQCTLDDDAFREDATTNSLQDYIAARTGHESALLVMSGTMGNQIAIRTHLAQPPYAVLCDHRAHIISSEAGGVSAWTGATVVPVTPKNGDYLTLDDIERSAVISDNIHHCPTKLISLENTLHGIVMPLDEAQRIVDWAHSNGILVHLDGARLWEAVVYASGRYSLRDYASTFDSISVCFSKGLGAPIGSMLVGSSEFIKRARWFRQSIGGGIRQAGVISSAARVAVDEVFGRDPYGEEGKMSGSHRRARHIASLWTQRGGQLLKPVQTNMIWLDLDASEVNPSYLREVGRQKGVRLSASRIVVHYQVSDETVSRLREVFDVVLQWPQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYI8</accession>
    <name>A0A5N6TYI8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">BDV25DRAFT_99436</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYI8"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="39299" checksum="557ED47C8D834B42" modified="2020-04-22" version="1">MCQSDIHDFLQGLPKCEHHVHLEGCLTPDLIFELAEKNNVQLPNSPAYESVEALHDRYGHFSNLDDFLSFYFTGMSVLHHESDFADLAWSYFQKAHADGVHHAEVFFDPQVHRDRDIPYETIVAGFVAGCHRAEKELGLTTRLILCFVRHLPLDSAARVYDEALASKHFEDDVLHGLGWSSTEVGPPKDMFRTLYSSASARGIPLTAHAGEEGDASYISTALELGARRIDHGIRLVEDPALMERVAKEGVLLTVCPISNLQLRCVDDIAKVPIRKFLDAGVCFSINSDDPAYFGGYILDNYCAVQDAFSLSVGEWRVIAENSVRASWIGEERKTELLRRIDEYVQKYVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYX6</accession>
    <name>A0A5N6TYX6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_128661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYX6"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
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    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8151586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="419" mass="45872" checksum="A55C48B432D90E3C" modified="2020-04-22" version="1">MDLANPNYDDLSLLGCELEFPFSGKAAPNRFLKSAISEGLASFSMAEPATRGIPSPEYINLYKHWGEGNIGLIITGSIMIDPEHLPATGNAVIPLGSPFHGTRFERFCQASSAAKRQGSLIVAQLSHPGRQTPLHLQPFPISASDVPLRHGMFGNDYGKPRAVSIGDIATIREGFVYAAQFLEKAGFDGVQLHAAHDSLLSQFLTLATNKRTDEYGGDIYNRMRLLIDIRQAISRQVSKDFMIGIKINSMELEKQGFRREDTLALHEALEACQFDFVELSGGESEGERAPSLKKTKVYVTGDLHSTRAMAGALAVVDGVGIARPLCQDPYFCDRILSGAVTEMTLVQSQSNNAYLGAIAALTQIAQLGQNLQPIDLSVPENRDRFFKSFVMHQRNRSDVNDSVPVLEGYNLGLRKALQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ67</accession>
    <name>A0A5N6TZ67_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_138601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4807664at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1302" mass="147133" checksum="1D88CC6E16C352F6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZA6</accession>
    <name>A0A5N6TZA6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_152487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZA6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="238" mass="26981" checksum="51829C5FFD4125AA" modified="2020-04-22" version="1">MVQNGRQYHAFKEGSYNLPNDEEEQARLNLHHHIHRMKLDGALYRSPLPADIERVLDLGTGTGIWAIEMADQFPKTVVVGNDLSPIHSNWVPPNLRFEVDDFEEPWIYSKPFTFIHARDLQGSVSDYGRLLQQALAHLVPGGWFEFADADLLICGDDDTLQDARHLHETSQVVREASARVGKVMGSAKQHRQRLIDAGFVNVQEETYRVSESLPAYVLFRKALNTCTGEMAERSKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZH3</accession>
    <name>A0A5N6TZH3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_87812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZH3"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33283" checksum="E1779619DCADCAB0" modified="2020-04-22" version="1">MGSVSVPQATNICLSADRWANIAYYRILRLTPNHAPRILYVKHDAMETFIMPKAPSWPSHLERLCSIPDFHKQDWTTMTLDESWIWPWGYTLHVDQFEAHCIPPEFLCSSLPKVNLVEFLPVESMMGDAALPRGRVFRAQYRGVSVVLKVANFAYQVRKMKAECDAYRVLLRNGCTAAPRLLGYVFEEVEARVVGVILEDVTGRRAKWRDLDACLAALGQIHQCKILHNRLNPEDILVTGGGVKFLDFGSSSFEYSPVEGWKQKTASEANLLGYIMARSGSGKKGVAEDDMEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0N0</accession>
    <name>A0A5N6U0N0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_138204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0N0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="32679" checksum="9E2225B3C42AB43A" modified="2020-04-22" version="1">MATGPPSYTKVTHSNTYAGIDPTQPGLSTAGKVVLITGASGGIGRATASSFAASGPQALILFGRNADALAETATVARARHAEVTIQTHDADLCDASSVRSALNKVAAEFGGIDIVVHCAGVLPPIAPLLEVDPATFMDGYKTTVVSTLVTAQAVVLANKTTSPNEDKPITFVNLTTAGVLFPPFPGTGAYVGSKMAAVKLLEIFAVENKNVRVHNVHPGIVKTAMLDKLEETIKLPFPPNDSSLPADFIVWVVSPEAEFLKNKIVFSAWDVDELKARKKEIVGDSPGAGELWMGFQGYPRFKNGQPVPGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0W7</accession>
    <name>A0A5N6U0W7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_73440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0W7"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="551" mass="61257" checksum="3F0F244048905E40" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0X2</accession>
    <name>A0A5N6U0X2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_151756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0X2"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="29051" checksum="330CE4709A085795" modified="2020-04-22" version="1">MARNSEKAQSMLFRFRAQQAADLGIIDIGRTRRPKAITSVDNIPMCEKWRGQVLKEISRKVSRIQEPSLSDYQIRDLNDEINKLMREKWIWEMQIRNLGGPNYMRGSGRVYDDEGREIPGGGKGYRYFGRARELPGVKEMFEAAARRGRPAEEDEEGAGRGRGGDVATKKVDANYFGYGLDEEDGTLVAYEKQKEKEAIERLRGKKKEEDAEDGWQPLPGDAGDGVEWRLPSLEEVQEELVDRRRRRLLEKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1J0</accession>
    <name>A0A5N6U1J0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative L-galactose dehydrogenase (L-GalDH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_170212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1J0"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="47964" checksum="926DDF32C94524AC" modified="2020-04-22" version="1">MPRPDVPLSATLPPLVMGTATFNSQYNPDPYALPTTELVRRALRSGVRAFDTSPYYGPAEELLGRALATESVSTHFPRHKYHLLTKVGRIASSSFDYTPAWVRYSVSRSLQRLHTTYLDAVYCHDVEFVTPGEVLQAVRELRRIRDEEGTVRYVGISGYPVDVLCGLAELVLRETGEPLDVVMSYANFTLQNTRLLTQALPRLAAAGVDVVPNASPLGMGLLRRSGVPVGSMGDFHPAPAALRGAILSAAEWVDAQGEKMEVVAIRFALESWLRDAGEVGALGAPLAKSADADPGFLSVLNMGTGERLGVSVMGVSTVDELNETLRVWHSIIEGLENKDEDQQLHTPSVLTPSEDAITDRAWSHSRRQRILDLTRQIQDILGEWVDYVWPSPGPDFVNTLPDDHVAFKKGLAVSGQDSEPITPPPETADPKIPVDTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1W8</accession>
    <name>A0A5N6U1W8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED8</name>
        <name evidence="13" type="ORF">BDV25DRAFT_150761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1W8"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1710:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="240" mass="26528" checksum="23014DD72E8BF20E" modified="2020-04-22" version="1">MSAPKQDQLKTLEQSRQRLVQLTHSLASLITSLNQSDPLPPWNSLQSQASIISKNLLSVSDHLSDNRELLTSLVAYPGPEYPSRTQANTLEQLLRTKLDPRVDDWVARGRKAGASALEDKGTLSEADLAELWDWAPVEANEEARQRNWGGNFTLEEREAGVQNVVTGLRRVLEDEGDESSEEEEGEEDEMEVVGVRRQSTGAGFEFDIAPASAHQKPVEPVVPLDGILRYMTTGVSPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U214</accession>
    <name>A0A5N6U214_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM5</name>
        <name evidence="13" type="ORF">BDV25DRAFT_150845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U214"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="83" mass="9050" checksum="EE921CEE8568125F" modified="2020-04-22" version="1">MASQLLPLELIDKCVGSRIWVIMKNDKEFSGTLLGFDDYVNMVLEDVTEFDYSGAQVKLPKILLNGNNVCMLIPGGEGPVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2H6</accession>
    <name>A0A5N6U2H6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_150410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2H6"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="835" mass="92152" checksum="654AFB68D85057DC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2K0</accession>
    <name>A0A5N6U2K0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BDV25DRAFT_150456</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2K0"/>
    <dbReference type="SMR" id="A0A5N6U2K0"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAE8152835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="151" mass="17169" checksum="89345B6BA251A556" modified="2020-04-22" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRKEYIKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2M8</accession>
    <name>A0A5N6U2M8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2M8"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="375"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="774" mass="86592" checksum="104072088932490A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Q7</accession>
    <name>A0A5N6U2Q7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Q7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="258" mass="29284" checksum="48D13861AC1F9F0D" modified="2020-04-22" version="1">MEIIQKNEAFKRIDGKMRFSYVQIFARWDGALYSGKWPNRHESPSTLEELQDLKQIPTEDRGPEVKTTWSAVFVKTPSLLAYVDGNLEKRISREVEICEILQKKPHPNIATYYGLNESHGRVSGLCFKRYTSTLLEAVNPLHLNKAAFLSSGRELVTESMKTGLQGLLAAIKHLHSLGLVHNDINPANIMLDGEGTLILIDFDSCRNIGESLRSTETKRTRHWHDPAVEISIEKNDIDAFKDLQTWLTGSTSEDFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2T3</accession>
    <name>A0A5N6U2T3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_50182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2T3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000030">
        <property type="entry name" value="Putative histidine kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000136">
        <property type="entry name" value="Sensor histidine kinase/response regulator Fos-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="331"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="587"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8152878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="706" mass="78453" checksum="4E237363CB459CEE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U308</accession>
    <name>A0A5N6U308_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit sconC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongin-C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_137457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U308"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
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        <property type="entry name" value="ELONGIN-C"/>
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        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="103" mass="11480" checksum="A3C4C21E19A99484" modified="2020-04-22" version="1">MASQPSQSEYVTLVSGDGFEYVIPRSTACVSGTIRRMLEPSSQFSEAITGRCVLENISGVVLEKVCEYFCFNEKNKKQMNVPDMDIPPELCLELLMAADYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3I3</accession>
    <name>A0A5N6U3I3_ASPAV</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_127468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8153134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3I3"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="57799" checksum="8689D4B62F450C5E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3J2</accession>
    <name>A0A5N6U3J2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_127492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3J2"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="71"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="552" mass="62914" checksum="9C74E0D1EFAA1BFB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3K5</accession>
    <name>A0A5N6U3K5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_42597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3K5"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="35"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="165" mass="18700" checksum="7D6B457A83FF7798" modified="2020-04-22" version="1">MSLFRTSFPTTGDFAPLFRLLDDYDSHRQTRGQASSVRSFAPRFDVRESENAFHFDGDLPGIDQKDIDIEFSDPQTLVIKGRSEREYHTPEAEAQNEGREVTKAEDKARFWVSERSVGEFHRSFTFPSRVDQDNVKASLKNGVLSVVVPKATAQGSKKITIENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3U8</accession>
    <name>A0A5N6U3U8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_127394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3U8"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF2">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="38302" checksum="925E57E88264D3E9" modified="2020-04-22" version="1">MPPVRVAACHVAPVFLSAQGTTEKAVRLIHEAARHGAQVVVFPETYIPAFPIWSALRAPAENHGLFHRMVTESVYADGKEIQAIRQAAQASGTIVSIGISEKTRFSTATLYNSNLLIDRSGAVLTHHRKLMPTFFEKLTWSPGDGHGLRVSPTACGNIGNLICGENTNPLARYALMAQAEQIHLSTWPPIWPTRFATGDEAGANYDNVSANRTRAAAHCFEAKCFGVLCSGFLDQTVIDSVSAGSHAIDAVQHTLQRSPRGVSLFLDPTGTLLPGFTFDRETAKRQETEYLQHQEGILYADLDLDRCVEGKQYHDVVGGYQRLDVFQLQVNRSRSDPVVFTELSVSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Z5</accession>
    <name>A0A5N6U4Z5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_168634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Z5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="681"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118268" checksum="28EAEA532680FCAC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U513</accession>
    <name>A0A5N6U513_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_149061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="517"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1617"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2743"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4288"/>
            <end position="4364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1692"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1699"/>
            <end position="1717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="4822" mass="527163" checksum="E22DE415F96E0ED4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U519</accession>
    <name>A0A5N6U519_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_168746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U519"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="531" mass="57756" checksum="66A0A47913926DE6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5H9</accession>
    <name>A0A5N6U5H9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5H9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="87" mass="10005" checksum="245824B506A8B535" modified="2020-04-22" version="1">MKLHRYALAACRHWCFVDPLHGCDIRHVTGYPALSRRNMVLIGGSHFYPWHYVCLHKCYGTCALSLAVSVQIVLWLGHLPFSREAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5T4</accession>
    <name>A0A5N6U5T4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1917-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5T4"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="301" mass="33249" checksum="B03F5EDA7A31AC76" modified="2020-04-22" version="1">MAKPQTNPEQDQDLLTPDSSFYGSDTEKARLEELADSYDPGIYWTETHPRVLSVLQWRARRAAHEEDGVKDEDGDDVLADATDVAVKVELEVPMGADVMGGESVSLSRAAGPWVYVLSPGVASEEGDVARLVRSGTKVLRRFTEQKVELEREHDASGAKTKIGLARKLTPLRLGAEREILGRAREAGVVRGKWMVFLGEDEVDEAWGSVVRETLDGRLGVAAKVGTQGKERLLAVYTRDFGDVDDVRRVVGRLVEMGLVDRKGKPVYYKCDAYTYLEILGGNSYGIKASMFSSRDVLERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U638</accession>
    <name>A0A5N6U638_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U638"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="9"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="34571" checksum="418932BAE79BD240" modified="2020-04-22" version="1">MTIETKLKVYILDTYHPDAINLIQTIPGLQVILPDDPRKEDWHADADGIMLRSDSHLTEKDFAKARHLRVVVKQGVGVDNIDLAAAKKHGIAVHNTPALNSESVAELSMALTLTLTRRVSEIDHAVRSGATVLRNKVLSTSMFGKTVGVIGMGNIGKIVAQKWIGAFDCTIVAFDPFVSADAWNDVPHVRAEALDDLLCVADVVTLHVPLLASTRGLIGERELGVMKDSAVLVNCARGGVVDELALLKALNENRIGGAALDTMEIEPPTLDVHGDFLKHDNVILTPHIGGSTKENQSRNGMFVVETLVSVLHGCEAVGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U693</accession>
    <name>A0A5N6U693_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_1497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U693"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="33"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="42800" checksum="3D59F374056C7AB8" modified="2020-04-22" version="1">MPIPWPPQSVPNEPGIATLSLGTWRHHTLQSRLEAAARAGYKWIDLFDECWAAYLEEHGLPGNSPWEPTADNLSVARKLGELVTSLGMKIACTQPLRQIEGVKDPEERRDRLETVAKRFPFMRAFGTDLVFMCANMRTDEGVTADLKSVARDLAELGDMAKVFAKRDGGPMLRIGYEGLSWARRNTWASTWEVVRMANRENVGLIIDAFNVLAVEFADPYHPAGHGRVHATMEAAVDVLCASMAGLVTSVPGEKIFFFQVGDAERMDPRVFQPPTDQDVPALLPWSRGHRLFPNEQGRGGYMPVLLVAAAVVATGYQGPLSLEVFNNSLNRPDADVPASHALRGMIGLRKLAEEIPRVPAFWEMWLQGREEFHDVSIHLRRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6G5</accession>
    <name>A0A5N6U6G5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BDV25DRAFT_1923</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6G5"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="21">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAE8154140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="653" mass="72846" checksum="B8F69876EF16A476" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U778</accession>
    <name>A0A5N6U778_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDSL lipase/esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_147694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U778"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35664" checksum="C5C645D0095B5C1F" modified="2020-04-22" version="1">MRPRVALAASALAGMTCGASLKSRVSSHWPGFDGLKTLFVFGDSYSRTGFDPTAEEQPSSSNPLGNPEYPGRTSANGPNWVDLLTVKHNASQLLTYNFGASGATLDTSIVDNGMDVIREIEELFLPNYGDNGTFEADSSLFAIWIGINDITNSYLTQNDSIHPAIFDSYRYRVDQLYDAGVRNFLLLNVPPLERAPRTTQSSASETRIPIERNATADWNSRTKTLQTRIQYLHSDATVFLYDAYTLFDEVIDNPSKYEQTSVYKNTTSHCEAYKNGTPEIDTKWDNCTYAADEYLWINNLHPTSPIHDLLAEQVAALLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U793</accession>
    <name>A0A5N6U793_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_147740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U793"/>
    <dbReference type="OrthoDB" id="4524685at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="498" mass="55280" checksum="997CFC421AFACA2B" modified="2020-04-22" version="1">MSAVDHAFWAAAASLETVLPPKSQVMSPVESTDSTEDARVMSFQLPGKPSDAKSAFETQLQEFTCHIQSLERGNLRIEIPASRRANEQPLSPPLIDARNAFPLRKRKIEWLDGEQNAYSDCSGTSPFASDDNYSLVKTALDEQTGDIMLPREVVSSLFRELLHHRAAGKQPDREIDLRKHQQRNKAFQTALQEIAKVIMKVANGDLSTKIPIHPLEMDSDIITFKVTMNNMLDQLRVFANEVSRVAWEVGTEGLLGGQAQVAGMHGVWKEVTDNVNTMALNLTDQVREIAVVTTAVAHGDLSRKIERPAKGEIFQLQNTFNTMVVQLRTFATEVSRVARDVGIEGVLGGQARVYGTQGMWHELTTNVNAMANNLTMQVRDIATVTTAVANGDLTQKVRADCKGEILALKNIINSMVDQLRQFAQEVTKISREVGTDGVLGGQATVHGVEGVWMDLTESVFLNDTCFRPFCLCFVDCERMFRRKEAKLWSFMCGMVCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7M8</accession>
    <name>A0A5N6U7M8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_147654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7M8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="225" mass="25184" checksum="327C9CCF265FDBC8" modified="2020-04-22" version="1">MQSKTDPSTARAVYRCHNDFGPLDPSGLGNMYPQITDFGAATLLGNSKANDTVELGTRPIQPDYYHAPEVVLGCGWSFSADIWNLGVMAWNMIEGTELFTQVQDEGNYDSKAHLAEMIALLGPPPEKMLNMSKSMAQVEWSPAITDASGRVYKNNREYFGGPFFDDSGNFLHNDLIPARKLEDTVPSLEVGDREAFLSFIKQMLTWLPEERKTARELMDHPFLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7T2</accession>
    <name>A0A5N6U7T2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7T2"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF164">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="363" mass="40282" checksum="5122DDA42939AE1E" modified="2020-04-22" version="1">MAGGENRSWVIETVSWPLFGLSAVLVVLRLWTRTRIIRSLGWDDAFIILALVCACVNSIMITISAHYGTGRHANTLTEYQQIMSTKYNWLSQGFHVMSSNWGKVSVAMFLLRIIRKVKHHKMAICGGMVLLTIINVVCVYTIYGQCTPTAKLWDTSVDGSCWDPGVQKNYAFFQGSSSAFSDLVLALYPLHTIYGLQMARKVKFGLATVLSLGIFAMVAAIIKTINLASLSARADYPWKTVDLAIWIEVEQYLIIIAACIPTLTPLFNIAIYKRSSKRNASSGKKVYTGPQYGRSDGYAQFGSRPGQEYPLDEYSGDIWTTRKDGDGNSDDPIITEEGGQGIMKTTEIHIQTGSMAERNDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7W2</accession>
    <name>A0A5N6U7W2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_94203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7W2"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="34372" checksum="3F3C291A102C546F" modified="2020-04-22" version="1">MNSPTMTSEFEPATLPPHAPRPSPIMDVEAFSSNQFLENLPEETEPIIATNKQAIRRALKKKLDTDEEESEFILFSYVGPQLFGQLSNDGGSRGEIGIRTFYDASSLNLIVKIPRRAHEAATRALEFLIVQEASRQGLDDQLLAVGSETIKEDPYSKEGDAAFIPQGPIPGRDDKWPTLVIETGLSESLLRLRVDASWWLTMSSGLVKMVIIISIDRAQPKILLECWKLGAVQHSHQLRSLCWNPLRPTKTHSITMTHNGTSTTIAGAPLVIPFDDVFAIPPSGPTQGDFVFGSAVLEGFARKVWRGQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7X7</accession>
    <name>A0A5N6U7X7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_94375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7X7"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="108" mass="12280" checksum="A755E346CDF0847F" modified="2020-04-22" version="1">MSRHHPDLVMCRKQPGISIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCIVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKSFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U804</accession>
    <name>A0A5N6U804_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8154539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U804"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="64" mass="6923" checksum="42565B2E35828AF0" modified="2020-04-22" version="1">MMASLLVYAGANLFMLDAYGPLYGASASGATMLSRYIMSFAFLCLHCGCFRLSVRAGELAFWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U847</accession>
    <name>A0A5N6U847_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">YL1 nuclear protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_82491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U847"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
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            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
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        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="726" mass="80164" checksum="B3DEAFFD6657A40F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U880</accession>
    <name>A0A5N6U880_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BDV25DRAFT_126237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U880"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="639"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="761" mass="86163" checksum="6005C806D5C575C8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U887</accession>
    <name>A0A5N6U887_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_147069</name>
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    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U887"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="405"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="522" mass="56905" checksum="5D5C31D0C0A694B2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8C5</accession>
    <name>A0A5N6U8C5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_82962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8C5"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000099">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="141"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="528" mass="57884" checksum="CC60A9F418EC1FDD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T6</accession>
    <name>A0A5N6U8T6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_170340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8T6"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63419" checksum="5836388D3C695958" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U952</accession>
    <name>A0A5N6U952_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U952"/>
    <dbReference type="OrthoDB" id="4494749at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="168"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="457" mass="52045" checksum="F470B8BC51456E18" modified="2020-04-22" version="1">MVHNVDDFQQIIDDLRPFWATEPWLLRQMAASLCERGDGIGGIHIRDKTVTKLSHPSWRIEALAAVISRFVNYLPDMGIAVNTLDQPRLVVPFDEIQRRLEVEQNLRHTYNMTEDSFTDSMDHLLNLTQSQGGWDKQTDPQWFSPPRQRLMEVAKMACPPETPARAREMTIEDADKLYKTPVGGFVRNFNLSTDLCTIGPTIEELHSLLIAPVSLSISQRLLPVFGECKEDTLLWRGVTSGGISRLGGWTRLHRQRLILLTNGTADHNETILILSEGAQNVYEPADYGPSDFAQDRFDVGFTEIRACEPDCSMYDSMVSVKPPVPLGEQFKVKYLVDIDGHGFSGRWRAFLFSRSLGLKATIFREWHDSRLIPWRHFVPLDNRHDFVANKIASQGRSWASQVLRDEDMDIYVFLLLLEYGRIIDDNRDHIGYGGDGGELDDFDKSFVTRDESISSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9F8</accession>
    <name>A0A5N6U9F8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_167705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9F8"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025094160" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8155253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="523" mass="57302" checksum="84731DBF35934794" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9J8</accession>
    <name>A0A5N6U9J8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9J8"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="114"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="588" mass="68342" checksum="512C7C24DB502177" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9K3</accession>
    <name>A0A5N6U9K3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_126056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9K3"/>
    <dbReference type="OrthoDB" id="4378483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="472" mass="54076" checksum="81567FC9D7AA312A" modified="2020-04-22" version="1">MDTAIFGPDLYAHKEGKAEQLATDMRIIKDTRRSWRLDMGPRLFDSRNPVGRYDKHMHTVVMKESEAWTRPVNDYPNIPLPMASPPRLGFVPRGRFLLKAMAQALPVSDTPFWHGVAEQVYGFSWCLVDNTVLCHKCVIGHCSTGVFCCFPDYLHFLEDLPTILDAVAQSVQDYINHVHQDHSDSVAHHKVMDSWMMCVQSIYLDVLHPKATRMRFPADELQSIKYRLIGAAGRALALHVQLEQHPIVGDDKIVDAVGFASTVMHDICDLRHDNTANEYYNLLTIVTAHKGVCSGTIMRRFCVDVWAWAIDHGALWAIHHAGRELVWQIYMARYKTPILLDNLHPPTSEENWTVDPYCDEVVNSFNPLPRSSDPYNYNLRDRCENVEEYDRLLDGCLTHFQECPDCKGYDKASWEERVPLIGNTYRKKYHDCSCLNTISTYMILASPDRLWWLADPTAAYTGPTAEWSNLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9L6</accession>
    <name>A0A5N6U9L6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_82608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9L6"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="358" mass="39540" checksum="98309D4F4CC9AAD0" modified="2020-04-22" version="1">MPGHFTQKILKTFGLEEPGQGPPQHHPQGNRHIEDNERHLAPTNGTYPRITRVGDNSLLASYTRFENGTRVLGVTRSTDGHHFEPWGEITRGAGDVDNAFILEIAPGTVLAAFRNHDLGDHGPTHFRITVCRSTDGGRSWHFLSQAAEKTPPHGIWEPFMRLGRGGEVQLTYSLEFAHNNQSTIMVRSHDGGATWSQPHCLHGDCDTRRDGMNGIAATWDNGREALVMVFETTTYGTFNLEALVSYDDGHSWDGRHQVYTPARGHNAGAPQIASFADGSLAVIFMTDEDHSEVQWTRNASIKVVFGSPPQNGQIHWSRPQVLCPHTSHWPGIATVAPQMLLATFECDGKPKAKAITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDI1</accession>
    <name>A0A5N6TDI1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="ML742524">
        <property type="protein sequence ID" value="KAE8144444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDI1"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="308" mass="35457" checksum="22A8564E61347A84" modified="2020-04-22" version="1">MPFTHHSHSGQFCPGHAKDNLEAIIQLAIAKKFRVFCLTEHMPRGQADFYPEEIEAGNTEASLVANETAYIAEAQRLRTKYADQIQILIGFEIDWIRPESRTLIDASLARHPFEFFVGSVHHTLTIPIDYDRDMYVKARDLAGGTDEQLFQAYFDEQLDMLQQLKPLVVGHFDLIRLKSDDPERSFQQWPAVWEQILRNLDFVASYGGMLELNSAALRKGMSEPYPKAEICQEFLARGGRFCLSDDSHGLDQVGLNFHRVLDFTETVGITTLHYLDLAEEGLVVDERFPRTRIRSIDREEFTALEFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDI8</accession>
    <name>A0A5N6TDI8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_167098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742567">
        <property type="protein sequence ID" value="KAE8144326.1"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Sato A."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Grigoriev I.V."/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="2 3">IBT 18842</strain>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742425">
        <property type="protein sequence ID" value="KAE8144847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="18453at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
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        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
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    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144847.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="590" mass="66565" checksum="8DD989E6F4E529DD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFF2</accession>
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        <recommendedName>
            <fullName evidence="7">Transcription factor TFIIIC complex subunit Tfc6</fullName>
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    </protein>
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        <name evidence="5" type="ORF">BDV25DRAFT_145026</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
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    </dbReference>
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            <end position="296"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145037.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="82883" checksum="F31838D12DD73B6E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFH9</accession>
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        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_77007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
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                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
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        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="153"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="60539" checksum="7BB0CB8EC00B46FB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFJ0</accession>
    <name>A0A5N6TFJ0_ASPAV</name>
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        <submittedName>
            <fullName evidence="10">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_77681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="H_N_K_Ras_like"/>
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    </dbReference>
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        <property type="entry name" value="Ras-like GTPase Ras1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
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        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="213" mass="23962" checksum="A20E018B122FF0B1" modified="2020-04-22" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVGNKCDLEKERAVTVEEGEALAQQFGCKFIETSAKSRINVENAFYDLVREIRRYNKEMSSYPAGSGAFGNRAPEGKMDVSDPGDNAGCCSKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFT9</accession>
    <name>A0A5N6TFT9_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742373">
        <property type="protein sequence ID" value="KAE8145202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1726" mass="187657" checksum="3E80E37D72839788" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THC2</accession>
    <name>A0A5N6THC2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Quinate utilization oxidoreductase QutH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742314">
        <property type="protein sequence ID" value="KAE8145775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THC2"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39488" checksum="77173E55AAE0F6CB" modified="2020-04-22" version="1">MDLRVVVVGAGLIGPRHAKSILSNPHTELVALIDPLPNAATTAQQLQTSYYPTVEAMLQAIPKPDAAIVCTPNHTHVPVSRELLASGVHVLVEKPVSDNIDNGVEMLRFLQRPENTHLKLLVGHHRRFNPYVLKTKEIVDSGSLGRIIAINGLWTLFKPDEYFAPPGDWRRAQSSGGVVPINLVHDIDILHYLFGPIVRVHAEKTLPQRPSPPHEAEEGAALTMRFASGVVGTFLVCDATPSPHNFETGTGENPLIPKCSSDADFYRIFGSDASLSVPDMTRWSYDGRSSKGWNQPLTAEKFDVEEATPFDLQLAHFVDVIQGEAELSCSGEDGLRALIVCQAVRKALDTGETVELDSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THM7</accession>
    <name>A0A5N6THM7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_163765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742309">
        <property type="protein sequence ID" value="KAE8145832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THM7"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="291" mass="31349" checksum="C8A002555F0882F6" modified="2020-04-22" version="1">MVTSNTPYKPSPLSFGSPRTSPFRRPSTPNSPPTGLRSSTPGSSPGRGYTPVVSPSKLNQSYTAELEDVSPSSRERIPQPRFSRGSPSASPTRGAMSPDTSPIMTRTAGLMTASSDAAARLAPAQLREIREAFQVLDRDNDGFVDKDDVADVLLNVGQDASRLSEFFPMGGAQTINFPSFLNILSNLLSPLSSRQELVNALAAFDEDDSGQVDVRELRDALLHTAPEDGEQPLSEREINEILDGFTGRRVFGGKGTTKGPGGNKRGEVFRYQEFVEGVLGTENGQTSRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI71</accession>
    <name>A0A5N6TI71_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742288">
        <property type="protein sequence ID" value="KAE8146074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI71"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02737">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="223"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="319" mass="34129" checksum="B775C221AF9FE945" modified="2020-04-22" version="1">MLLSSLRSLYCRRPPIASCAFSTSSAAYTAEVKSLGVIGAGQMGLGIALVAAQKAQVPVTLIDNSQASLDKGLKFADKLLEKDVSKDRITREAADTIRSRITPSLKMDDLSSTDFVIEAVPEISDLKTSIFAKLALIAPKHAILATNTSSISITKIAAATTADPTDMQAPSRVISTHFMNPVPIQKGVEIIAGLQTSKDTIDTAVAFVQRMNKIASVSADSPGFLANRILMPYINEAIICLETGVGAREDIDNIMKNGTNVPMGPLTLADFIGLDTCLAIMNVLHKETGDSKYRPSGLLRRMVDAGWMGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIH2</accession>
    <name>A0A5N6TIH2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_60423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742303">
        <property type="protein sequence ID" value="KAE8145899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
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        <property type="entry name" value="FoP_C"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="322" mass="36118" checksum="13CB84B74E9D6258" modified="2020-04-22" version="1">MDRSLDEIIAERPQKQNRGGRRPPPQGRRREGVRKSYREDRPDLDLDWVHDKYEDDRDSRPSRAPRRPRGDRYSPSPDHGAPTGGKLRIENLHYDITENDLEDLFSRIGPVTNLSLVYDRAGRSEGVAFVTYTRFSDARTAISEFDGANAKGQPIRVNLVSAGGGRRDRNPFDNVERPKGSLFDRVERPRGRDSRSLSPGSDRDDADDGARRRRGRRGGGGGRYRRSDVSKPAPDHIDRYVPGQRSPVRRPANGRRQGENRRPTAARPKKTQEELDAEMDDYWGTANPGAGTADKETVPEEPQQIAPATSAAAGDDDVDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIK9</accession>
    <name>A0A5N6TIK9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polarized growth protein Boi2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_54789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742281">
        <property type="protein sequence ID" value="KAE8146175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIK9"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="725"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="583"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="364"/>
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        </location>
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        <location>
            <begin position="942"/>
            <end position="952"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146175.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="980" mass="106569" checksum="4D8F56575BE3A889" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIQ1</accession>
    <name>A0A5N6TIQ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_169993</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="83"/>
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        </location>
    </feature>
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    </feature>
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            <begin position="274"/>
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    </feature>
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            <begin position="307"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8146207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="463" mass="51443" checksum="AC1AAE386853E920" modified="2020-04-22" version="1">MNPSSLSPRETWRLLILVGICSGILFNTFQDEGAPLIASIAFSGIAFSVTYSLITWLSPVFMKAGLKGKDMAKPKRPEIPESMGAVCAIVYLLALIFFIPFAFYKDIVAATSGGGNRDVVLEVHHVETGRMLHRFPHGRLASYLSGLLSLQCIVILGIGDDLLDIRWRHKVLIPAFGAIPMLIVYFVDFAVTQVVVPVPLQPYLGSFVDLGWLYYAYMAAVAIFCPNSINMLAGINGVEVSQSLVIAILLIANDALYLAPVTPYPHPATDSHLFSLYFLLPFVGVSLALLFHNWYPSKVFVGDTYCYFAGMVFAVVGILGHFSKTLLLMFIPQIFNFLYSTPQLFKLIPCPRHRLPKYNTVTGLLDASVTEWTVPPSPVVATGLEILHRLRLIRVTKDSRGQIVESTNLTILNLWLVWMGPMKENQLAWSMVAVQMVCGIIGLFIRHRLALLVFREDNRVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIR4</accession>
    <name>A0A5N6TIR4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742277">
        <property type="protein sequence ID" value="KAE8146236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIR4"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="394" mass="44225" checksum="E8CAA006D7C11458" modified="2020-04-22" version="1">MDRTRALVQSFGDILRRLTYRETCTGPSLGPQLAPKGRKRERSDSEGVASKRTVSSNISNSEVEQLSAGKELENSPPVTSILDVKDEDEAKDAVLETLWNEKPSGIFDFSAERARRWASAVDLPEGLYNKAEQDIFFRLAMRGFEPIIPRRWRHDFPTLPSTLFADQNDDEPEPLIRALKPTQTYAIKSLSNLFSLGGRVRDHRILGLSPEILIKKAIEKYINWALNDVNLHMESETPQLHLVRTLDEGETTLTAVTRLNQRLQSMAIQYNKVMGMTVIGNDHSSADSRIKEEDHVLTENQDPRVYPLLIGFLICGHMVTILTLGTDPSSTTNGADSKFMFNFDLEESGQDVWNSLAIAIIVMKVRDTMLQLAKKGICGFGQDSQCESVLDEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIW7</accession>
    <name>A0A5N6TIW7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742272">
        <property type="protein sequence ID" value="KAE8146296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIW7"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="389" mass="42568" checksum="E007F717076C27AF" modified="2020-04-22" version="1">MMADPADLNLDAPSDLQDIPEMSMQLIPPPEGTFPDKASLLASVQAHGKAHGYNVVVKSSSTPTEKKPGRTAKVWLRCDRGGHYRPRNGLTEETRKRRRTSRLMDCPFMLVAAGTPGIWTLTVLNPTHNHGPVIEKSRQAPQHKVRKGQVAALPYDWPHDATLTPYTTALVIVDMQKDFCSPGGYLEYQGYDISAAQALIPKLQHILNAFRSAGFPVYHTREGHRPDLSTLSSREAYRSRNNNSGFGIGSQGPLGRLLIRGEVGHDTIDELYPLPGEPVIDKPGRGAFAHTDFELLLRNKGVKNLVLAGVTTDVCVSTTMREANDRGFDCVVLEDGTAASEPPLHMSTIESIKMEGGIFGAVTKVDDMVHAVDNFKNSTVKKLAPQMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ71</accession>
    <name>A0A5N6TJ71_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_50826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742263">
        <property type="protein sequence ID" value="KAE8146418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ71"/>
    <dbReference type="OrthoDB" id="6090458at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024873015" evidence="2">
        <location>
            <begin position="19"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="800" mass="84283" checksum="8D1B1C44362C46F3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJE2</accession>
    <name>A0A5N6TJE2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_49718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742260">
        <property type="protein sequence ID" value="KAE8146462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJE2"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="443"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="562" mass="65987" checksum="D465F3E81EF72B83" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJI2</accession>
    <name>A0A5N6TJI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
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            <strain evidence="2 3">IBT 18842</strain>
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        <source>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="68" mass="7300" checksum="AA32A84EFD13EABF" modified="2020-04-22" version="1">MGGASREGGKVKPLKSAKKEKKDLDDDDLAFKERQKAEAKAKKDMLDKAKGKGPLNTGSQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKB1</accession>
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        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742256">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CID_dom"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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        <property type="entry name" value="Surp"/>
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    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
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            <end position="446"/>
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            <end position="681"/>
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    </feature>
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            <begin position="731"/>
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        </location>
    </feature>
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        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146549.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="808" mass="88777" checksum="4A0B39F9EC1D25D1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLC8</accession>
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            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
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        <alternativeName>
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        </alternativeName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="131"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="47631" checksum="858016AD41068BAA" modified="2020-04-22" version="1">MAAYIPYPFPIPENSPFPISNIPFGIFSTAKEPTPRPGTAVGDYVIDLSRLVSRGLLRADGNTVVQDALREPTLNSFAALPHPIRSKIRKDIQKLIGDEESPLYHKSGQSKFLAVRADVTMHLPFAIGGFTDYTCSLEHVTNLERLRGSSTIPPAFFTQPLAYNGRISSIVPSGTPIQRPYGLTTDRLYPSAKLDYEVELGMFVSTGVPVGDLIPASHARNHIFGFVLLNDWSARDVQFAEMVPLGPFNGKACGTSISVWVVTFDALEEAGAIIPVAVEEPVQGKMTSNPFLRHLEDISIDVSTYHSRNSDQRAPICRSNLKHSFWSPFQMLAHHTSAGCGLGPGDLIGTGTMSSSAEQVKRDFTMSTPGVGRLGCLQELTEGGAKPVQLGGDQSLTWLKDYDEVTLEGWAGEGRARIGFGEVTGRIVPSNPSLSMLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLF1</accession>
    <name>A0A5N6TLF1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_37458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
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        <property type="entry name" value="GAL4"/>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="62790" checksum="13774D56BC5C0720" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM22</accession>
    <name>A0A5N6TM22_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742209">
        <property type="protein sequence ID" value="KAE8147396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM22"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="251" mass="28812" checksum="6FEFCFC491165F0A" modified="2020-04-22" version="1">MAPEIGKPLYGVDGKNANVQRLFKTRQFSLYDHTLITTDFDALKFHAASSLQLQFGLPHETAAPQSNHLITSPYNEPKHLLDLTTLDLPNQLLAKALTILKPTRADYATASYTETFNWQSVFDFLRDLSQAEGYQWQKQHFYVVVFRSRLHADIDNQRLHDLDAYSHQEACASGGLLKYWFGTKNADQQNLATCLWRSRHDARMGGTGPWHKKARGAARELYEQITFTTLKLVVDDDVRSWSFSDWTEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM80</accession>
    <name>A0A5N6TM80_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_160365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM80"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="431" mass="45775" checksum="62B5835FD44DA51C" modified="2020-04-22" version="1">MMPICIECSYPVSHLYSTYSRADDRSLGKGVRLTQCPRCQRFADKYVEYDFVVIFIDLVLIKPQVYRHLLFNRLGGDNNQFDRSIIRLGVLLLLFDVYLTWARIEKSPSLASTFLSRAPIVVQYFFFLGLNALATLAHHLTIRLLASILAPMPRGWKQNAINPSNTADSPLSTPSTPVLPSPPQAATAQSQVSPTSIPILSPPRFNRQGSSNDMTGGLLSAADHPGGEKHAVPPTAQGSLPPPPLRRTSTAPIQSIQPLPPPSPASPTAISTALLVSSCAKLFPILLVIWGPDGSGVTSDAPASNSAGTSSVTPVNVSQRALDGITPAATITATPSGVTRSTAAASSTILESLVQMMPDSVPTSYLAHFLELTGSLFSLGAADTHLVLLSNIEALYVLLGCGYLRAMTLAVAGLMARWTVQKVILGAIGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMF7</accession>
    <name>A0A5N6TMF7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rogdi leucine zipper containing protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_131987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742202">
        <property type="protein sequence ID" value="KAE8147543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMF7"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1176"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1204" mass="135120" checksum="B6D678E9CE3831B8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMN9</accession>
    <name>A0A5N6TMN9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_159966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742198">
        <property type="protein sequence ID" value="KAE8147633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMN9"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
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        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF280">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05170)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
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        </location>
    </feature>
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        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
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            <begin position="343"/>
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    </feature>
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        <location>
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="441" mass="47740" checksum="77ED313B0FE7FB28" modified="2020-04-22" version="1">MGTNADIEEKVVADPQAANNIHHDSEQASDLSNPASEEKPEEPTFDTGLTTWLQVLGSFFLFFNSWGVINTWGAFQTYYEQTFLSHMSSDSIAWIGSLQSFLLMLFGVVTGPLFDAGYFRGLITFGTVGLPFGLMMTSISSKFWHLILAQGVVIGLSAGCLFVPSVAILPQYFRQKRGLANGLAASGSSIGGVVYPIMFNQLQQKIGFPWATRAVAFLCFGSCCISCCLMRMRFQPKEKRKLIQLSAYKEPQFVMFSIALFMGFLGFYNFLFYVQSYAMDTGIVDSNLGFYLLSMLNAGSTVGRVLPNFIADHTGPLNMLTPAAAATAVLAFAWIGVHNVPGIIVLSVLYGLTSGGFVSLPPVVMASMTKDIRDLGTRLGMVFSTTSVGLLIGTPIGGAILDQSNSYLGVQLFTACCLMTAASVFAALRFSRTGFHLVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMX1</accession>
    <name>A0A5N6TMX1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_32849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742206">
        <property type="protein sequence ID" value="KAE8147459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMX1"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
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            <begin position="630"/>
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        </location>
    </feature>
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            <begin position="20"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="666"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="82799" checksum="4D81C5F185CBD337" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNI1</accession>
    <name>A0A5N6TNI1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_159340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNI1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="157" mass="17344" checksum="32E8D4302F6F14BA" modified="2020-04-22" version="1">MASVNSMPAANNASGTSSINPSTQNSSARPSLRSSVSSKADGGRRQSGNPLEGNQRYVVLSIQGSQLFVFFMFSSTYWYPLLLLLRISPLVMHQCNVRRLLSIMPCILICTAMVPLLLVSFSFFSLSLPAFACHRIKTPLRRLAFRAVMPAVLRSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPM0</accession>
    <name>A0A5N6TPM0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BDV25DRAFT_158598</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="ML742166">
        <property type="protein sequence ID" value="KAE8148306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPM0"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="26">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="380"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAE8148306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="744" mass="83867" checksum="E8B850739A7E0376" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ24</accession>
    <name>A0A5N6TQ24_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stretch-activated Ca2+-permeable channel component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_131411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742169">
        <property type="protein sequence ID" value="KAE8148229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ24"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137521" checksum="8508F0F0F9A88CC6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ98</accession>
    <name>A0A5N6TQ98_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_158605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="387" mass="42869" checksum="C0A59A85C1C15064" modified="2020-04-22" version="1">MRPLFRCRQFLKPLPNYISSNKRPLSVIRPDMSAPTSRKSSVPHKVRTAAEPRQNTLYNVRLSHIEEINPTVRLLHLAVPPGTQSLEEQNSDQEEPDQSQLFTFSPGQWLDVHIPSISDAGGFSITSTPADAEALPSLQPDEETLPVDDEETGLPPVDPRGRAPYVELAVQKAPSNPACSWLWKPKEEILGKELCIRVGGSFVWPPSNVDLQNIKNVALIAGGVGINPLISILSHLNNNADETPASHHPFNVHILYSSKLPESALTESVSSPESALDQILFLSRLRQIIRSQSQSHRLQISLDLFVTNLQGTASRILQQPTDMAVHSKRISPDDLHVALAGPDGSIDPRATVCYMCGPPAMTDEFVTILRQWMGNAKEQVFFEKWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQB3</accession>
    <name>A0A5N6TQB3_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_158024</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
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    </dbReference>
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        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative (AFU_orthologue AFUA_4G07540)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148556.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="974" mass="105319" checksum="AD3CC3DDBABC489B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQT7</accession>
    <name>A0A5N6TQT7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_158184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742158">
        <property type="protein sequence ID" value="KAE8148499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQT7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="300" mass="35230" checksum="11E8F041AAC30624" modified="2020-04-22" version="1">METPEMKQQTRMDLLNRISKVNAMCRHLMHIFHEIKHSERSSLTEANMKELRITHSHLDLDEPCYDDSTFYKPLPKSEFPKIDWSEVHFSEWVEHYSAEPRRVEDTLQTVCNELFFAWFNDDTKQHWVQRKCYHEKPSIGTGEYTPDVPYEWRTCGDMEATSLDHPHCIFRIIHYAVPEEPLRRGEILPIAAYMKWRAKQLDHIKHFTFPILVVSIFRSQARILQAHHDGKHLHIRKSKFYNFEENNTENYELFARWLSGAPCGATKTPLPIDGVPVNNRTIQKVDRVLEGVFGGGGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQZ1</accession>
    <name>A0A5N6TQZ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_12114</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="ML742147">
        <property type="protein sequence ID" value="KAE8148773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="869"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8148773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146222" checksum="77527D5C5DB2FE5E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR81</accession>
    <name>A0A5N6TR81_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YABBY protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742143">
        <property type="protein sequence ID" value="KAE8148862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR81"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YABBY protein C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="69" mass="7747" checksum="FADDD1DA5D8E3B71" modified="2020-04-22" version="1">MAASSKPQNRGRRLSAYNQYMKDQLPQYKAEHPDVAHVDAFRAVAKMWKDCAQNPRSAQNGPEEVVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRH2</accession>
    <name>A0A5N6TRH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_10446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742143">
        <property type="protein sequence ID" value="KAE8148884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRH2"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="503" mass="57488" checksum="5C7BBA4A1D1DABAF" modified="2020-04-22" version="1">MLDNIFNLGLYNPSTAVLCLGAIISVTWLLPFLYDILFSPLRNVPGPIWTRFTNLWEFYILLKGNSHEEYIHLHERYVRVGPNRYSVIEPRDVKMVYDFGGAFLKSEYYDGQGTANIFSTRDNEDHKDRRRKIASLYTMTAMVGYEDAVDRMTALCIEKMRHFATVKHLISVPDFMQYYAFDVIGEITFDQNFGMMENMGDTQGIIKEIHATNGTMAHLGLLPELQSPYGLWLKIFGGAAGRLNTYIWSQYWKHRNANSGAKMKSQYDTFLRKILSMEAAHKVDQKHVLDGCGSNIGAGSDTTGITLSAALYYLYSNPDKLANLRREIDTLADEGLISNPVTYGQAKDMPYLNAVIKETLRMHPAVGTILARVVPKGGVTLASGYYFPEGTRVGTNAWPLHYSKDVYGTDAEKYRPERWLEEATQPDFRDSMMFAFGGGSRTCIGKNISLLEITKVLPQIVRNFDLRFEQEKEPWSNYCAWFVYPRYKCWVESRKDQDVERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS72</accession>
    <name>A0A5N6TS72_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase 12 kDa subunit mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_156771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS72"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="101" mass="11651" checksum="E744469087576145" modified="2020-04-22" version="1">MPTPESAAFLAKKPTVAPTYDGIDYEDTVAVHNARDAIIREQWVRSMMSRLVGEELGKCYAREGANHFEKCGVLREKYFELLGERKIKGYLFQEKNYFAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSI3</accession>
    <name>A0A5N6TSI3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucoamylase</fullName>
            <ecNumber evidence="10">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_156994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="ML742135">
        <property type="protein sequence ID" value="KAE8149099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSI3"/>
    <dbReference type="SMR" id="A0A5N6TSI3"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025002906" description="Glucoamylase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="505"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8149099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="611" mass="65758" checksum="FF2FEFE48A2F193F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSL1</accession>
    <name>A0A5N6TSL1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative adhesion regulating molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_4250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742128">
        <property type="protein sequence ID" value="KAE8149290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
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        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="387" mass="41650" checksum="7E40C7C4D1FE711C" modified="2020-04-22" version="1">MSITPIITFKAGICDLDTSGDTQLVKPKSTPGYIYLYSEDELVHFCWRPRTASHTEPELDLVMVPSDGSFTPYRPAGKANPTNGRIYVLKFSSSSQRYLFWLQSKSQHEEEDPSFFSPRDVRLGDIVNTLLQGEDVDVEHEIANLPRGPGGGDDDETMEDVEGVDHNPNHNHGGNSGGAGPDATGGDIREEGEESREGGADGGRAAAADSNPSSVVQNFLQSLQGGSAGSRSQDPERPFTTLQELLSPAATLPFLEIADEKTVDNLLSFLPPTLLLLAQDVDDISSIDDPEIIEAVMASLDISQKKNILRKVLHSPQFTQSLASLTVAIRDGGLPSISEALKIPVENGGFMRRGGVPLGGGDAVEAFLRGVRGHVQDSPQDNQMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSR4</accession>
    <name>A0A5N6TSR4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_3810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSR4"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTW1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="396" mass="43670" checksum="BB1A9E9DE316CE5D" modified="2020-04-22" version="1">MSHEKIKVIIAGAGIAGLTLAIALRRLPYIEVEVFEQATELREIGASIAISPNGLRSLERLGVLNALEEAIGFRNPSGVPMIFRHWETDEIIREEPFVDVPLRRHQTARFHRAQLQSALLEHVPPSIIHVKKRIARAEASDDHVALFFADGTSAVGEVLIGADGIHSNIRKTFFPNHRGFPTGKVWLRSAFPYSTVENIPSLPADSAQWWGPKGAFMASRMGKDLFTTVCNFDLPIDTIKDIQSSQEGSVEVLRQRFQSYSPVVQALAHATPYTRAYPNYAGEPLSTWLLEQRVTIAGDAAHPHGGAFAAGGSLAIDDAYALFLAFEHALGRERTCKPTLVEIQCVLAVYDQTRRPHASKLCTLVLEGLRAQSSITRADDNPIDRVNDKPNATWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU20</accession>
    <name>A0A5N6TU20_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_130025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU20"/>
    <dbReference type="OrthoDB" id="4378483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="47794" checksum="5F4280B6D33F3584" modified="2020-04-22" version="1">MKLSLFGPDLYTLYRDTTSVLTADMRMLPELMNTWTALTAPDFFLHSPVGKYDKPMNGLVFGECVAWSRKLNHFPDLPVPIDAPSRMGLIPRSNILFRAMTDAFSVPDTEFWRAVCEVAYGYSWYLLDNIILCQQCVQGSSCMAMLACFPDYFHFQGDLHTVLEACSQLLDAWFMTVQSVYLNVLHPKAHSLNFPDNELRGIKYRLIDGGGRPLASLAQLEQRPLVGGAKEVNAVAFASTMMHDICDCRHDNHAKDRRLSTNPVHRLCIDVWAWAIDHGAQWAIHHGGQELAWQLYMARYHTAILLDHILPPTSQDTYDPYGDDALNTLNPLPRSSDPLNFDLRSRCQDPTRYDSLLSGCLEHFNNCSNCRGYDRTKYTDCTCLNVIATYMILADTDKLWWLPDPTAKYTGPTGEWSPMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU38</accession>
    <name>A0A5N6TU38_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU38"/>
    <dbReference type="OrthoDB" id="5308323at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868752" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20822" checksum="22AEB2492A6FAE2A" modified="2020-04-22" version="1">MHKPFVLIPLLLSAVTAVPTPSELLPRACTTLAPSAIDILDASTPSSPNTGTQFQLERTSSRQNVKISALTFNNIPAGSTGCRLEIEFPPLTRSNEVAHGANGAQVWSTDPWEASSPPTWSQQPNKREMVGTYNFPTAQTQAPSHTVIASNSCSSTMSWLVELADWQQTEGGVDFQNSVNGIEKTGFMLVFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUC9</accession>
    <name>A0A5N6TUC9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-activated chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_155447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742109">
        <property type="protein sequence ID" value="KAE8149900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUC9"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="169"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="739" mass="85299" checksum="9C47C61ABAB82FD3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUI4</accession>
    <name>A0A5N6TUI4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_129895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742105">
        <property type="protein sequence ID" value="KAE8150026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUI4"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="558" mass="63674" checksum="BA2196855544647D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUS1</accession>
    <name>A0A5N6TUS1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_117611</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUS1"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024907644" description="alpha-glucosidase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="16">
        <location>
            <begin position="98"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="392"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="18">
        <location>
            <begin position="728"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="17">
        <location>
            <begin position="836"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8150115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="965" mass="109936" checksum="8C6C0AB24C774FF8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUV1</accession>
    <name>A0A5N6TUV1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_155142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUV1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="53" mass="6545" checksum="9DC4CA997B607193" modified="2020-04-22" version="1">MIWFPSICMAMQLELLLRNLVTWRSTLWIASCLVYWGWTETRNLEMAHWWSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV88</accession>
    <name>A0A5N6TV88_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_172280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV88"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="503" mass="54162" checksum="89104563455C222F" modified="2020-04-22" version="1">MRVAAPITCLLAGGNAVVHAFSSVQHRAQPNGSVSANCEKACAELSTAFGLALHYPDSDNFTIWDAKQQEVRPACRIEPSNASQVSQVLDILVNHWCHFAVKGGGHSRNPGDSNSVGGVTVDLDRMTQVKILDESRARVGGGANTLQVYKALDSHNLSFVGGRVGTVGVGGFTLGGGTSPFTSKYGWALDNVYEYEVVLANSTITTANETHNADLYFALRGGGNNFGIVTAFTVRTFTQGFVSTTMTTYSRNQTAKVLDQVYELSTDETLTSDPDMSYDSFYTYSSADDSFILSGTQRYAKPVRNPAVFDEINRIPTLTRSTTISNMSSLTHDPEPLGVTRHLFGTLTVAPSRSLLARAVTIFEQEVQAIKSVECMVANFITYAVPRTAIAAMKQRGGNALGIHGDQPLFLILISTAWSDASGDTAVNTMTENTIQRVKEAAASLGVANPFLYINYASAAQAPEVFAGYGEKNVQRLQEIQRAVDPRGVFTSQGLWTGFVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVG3</accession>
    <name>A0A5N6TVG3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_154595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVG3"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="522" mass="57494" checksum="753C961A589AE7DB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVU1</accession>
    <name>A0A5N6TVU1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_139821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVU1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="7"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="56433" checksum="CB94A95011E66A34" modified="2020-04-22" version="1">MGERYYTLSEGCPYASNSTSVQVRNRSGGGLALLQDTQLIETLAHFSRERIPERVVHAKAAGAYGEFEATDDCSDITSASFLNKAGKETPVLLRVSTVGPETGSADTARDVHGWAMKLYTDEGNLDWVFNNTPVFFIRDPIKFPSLNRSHKRHPRTHLPDPNMFWDFHVGNPEGIHELLHLFSDRGTPRSLREMNAYSGHTYKFTKEDGSFKYVKIHIRTALGAKNMTREESIKVAGENPDFYIQDLFEAIEKGNYPVWNVYVQVMDPAEAEKYRWNIFDMTKIWSHKDFPLRQIGTLTMNRNPQNYFADIEQAAFSPSTMVPGIAASADPVLQARLFAYPDAARYRLGVNYQQLPTNAAKAPVYCPFQRDGKMRYDNNYGSDPNYVGSSLKPTKFYQEVKTSGTKRLSLLTEHEKWIGEVVTFQTHIADDDFVQPAALWDVIGRDPGHQERTIGNIAVHLKGVQSVQLRNEVYALFRKVNTKLGEDLRKATEAALVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW00</accession>
    <name>A0A5N6TW00_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_110780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW00"/>
    <dbReference type="OrthoDB" id="4570620at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="391" mass="43331" checksum="076BD8BCF7978C0A" modified="2020-04-22" version="1">MMFACDSKVLFYIIFTLVSVCFAYVPQTDYDVIIIGGGPSGLSAASALSRVLRKVVLFDSGKYRNRVTRHMHDVIGNDHVEPPVFRAAARKQIAFYNVTTFVDQEVIKLENLDKDGFRATTSNGSYTARKVILGSGVKDDLPDTPGLQEAFGKGIFWCPWCDGFEHRNQSMGVLGELSDAFSSVKELHPTLNKDLRVYSNGTNTTAQRAKLDEKYKGWKKVFQTYNVTINNKPILNITRVQDGATNFNGATRQEFDLFRIYFRDNSSELRGAFIANYNTSQASDLPAQLGVGMLGSKMNTTGRGLETTVAGVYGVGDANSENTTNVPHAMSSGKKAAVFAHVKMAGEELDRDIGASKRAADLDERSLHKNAEKDMGNEIMDLYRKLRRNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW39</accession>
    <name>A0A5N6TW39_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW39"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="361" mass="40016" checksum="7D4F17205BAD86D1" modified="2020-04-22" version="1">MPRTLPWLTSVKSTSTKRESTPRPSAKAKRERENDSDATPKANGSRAKKQDLFISSPTPPSSPIYRCPTEEFLIEGLSNDDIYIMVEDEFNSVAQSFTQHLHYAEYVKRKKEAKEQNAAAIQSLARPTDGVTPVSEETKRRHASDVLYALQNTGLEVMGSKRPPVESDEEKEEEDETWAGTSLHDLMTSPRKTRSLMGMQGIKSSTRAAAGFSQASGSGKEIDSSPPKAHTVNDYDETASEDDNLDLQRTPTMKPAQRTRSVKSESISSNPRSSPLSPTKRRADKVHSMDTTYRTPASTISKRRLRFDDLDELPALHNSNVQVQGAGTSPSISKAQHNNPPSKNNPQSKKSRLNEVPTFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWC1</accession>
    <name>A0A5N6TWC1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_153971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWC1"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="245"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="521" mass="57510" checksum="551628B59277B342" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWN0</accession>
    <name>A0A5N6TWN0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_153762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWN0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="75" mass="8399" checksum="59418712BA6AEE09" modified="2020-04-22" version="1">MQRRSHLLHHGPLSNINSSPLVSSEISPKHKESRIIILDPPPPVRNVGWLITPVLSTVLVFAHLPIVSLRRLSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWZ8</accession>
    <name>A0A5N6TWZ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_129444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="10">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="9">
        <location>
            <begin position="550"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="9">
        <location>
            <begin position="747"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="824"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1291" mass="144218" checksum="99CADE7CFA2DB5B9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXG6</accession>
    <name>A0A5N6TXG6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COP9 signalosome complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_101056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXG6"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
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        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="246"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="54917" checksum="7718EA87421C1C0E" modified="2020-04-22" version="1">MDPIPGDTFDSQATSLYAGQVPTIGNTELENLNGASQTPFVKVDDPPKFELESYIANYTGRTRFNRLFLIGTCSTYLSVEALKAAIIEAKSSKDVSRYERAVRALAEVASNEPEATPDKEWVDRMRKVVKAETDRLEHELRGYKNNLIKESIRMGNEDLGQHYHQIGDLSSASKAYSRMRDYCTTPTHIASMLFKIISVAIERGDWLSVQSHVQRLRNLQSKQEEQAKNQPKMSAALGLSQLHSGSYTDAANSFLNTDPSLGDSFNEVLTSNDVAVYGGLCALASMDRNELQRRVLDNNSFRNFLELEPHIRRAISFFCNSKFRPCLEILESYQADYLLDVHLQRHVSTLYTRIRTKSIQQYLIPFSRVTLDSMSKIFSPRAVGGQAHPVDSTSPFVQELIGLIQDGTLDARIDLEKMVLVSNQTDLRTEVQEATLESLSSFVREAHLRVLRTNIIRAGLEVRVLSDERKQGPAGLGGKHPRPPPGMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXH0</accession>
    <name>A0A5N6TXH0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXH0"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005127">
        <property type="entry name" value="PRK06565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF11">
        <property type="entry name" value="AMIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="675" mass="73563" checksum="AA796FFB637252B3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXH9</accession>
    <name>A0A5N6TXH9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_129278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXH9"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000098">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="18644" checksum="79C40B0FD466A54E" modified="2020-04-22" version="1">MASSSTTQRLLRELKDYTNNPNEALLHLGPVDDDDLLQWEAVLKGVKGTPYEGGLWLLSITIPPNYPLSPPTIRFNTRISHPNISFTTGDICLTLLTTEHWSPVYTLSSTLTAIHQLLTDPSPDSPLNVDVAALLRDGDIPAWESIVRYWTEEERWQGPGSSSYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXI4</accession>
    <name>A0A5N6TXI4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_105653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXI4"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="64373" checksum="CEF79D9E65D51271" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY32</accession>
    <name>A0A5N6TY32_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_152928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY32"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000016">
        <property type="entry name" value="Checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="36145" checksum="29E2F48113748088" modified="2020-04-22" version="1">MRFRTQLCNVTTFSKLIGSLSSLGKVCWMRLEDGIIRFTIIPDQGTQVWAQLPVDAIFEESTYILEANSGVINLEVPVGALHRALRSAVAATSTQLRLTKKGNVPLLALTIHASSWTTGSNALGIADADQAATDHATVSGPRERETVIAQEVPVKVLHELSVEGLHEPRCRDPDVHIILPSLFQLKSISERFTKLATDSKGAGTALSSVAPKLELSANMHGSLKLAIATDSLRISSVWTDLVNPALDPAQLSQTELEQLPSERMRAFRDDDEAGWAKVRIDGKDWGRVLSVGRLSPKVVACFIHETALVLYVYLPGNGDDSCLTYYINSYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY43</accession>
    <name>A0A5N6TY43_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_128923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY43"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024931151" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="553" mass="60297" checksum="ECD9702F66CAC060" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY90</accession>
    <name>A0A5N6TY90_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY90"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17933" checksum="AB5328836E552BE0" modified="2020-04-22" version="1">MFPSGVIPNFYGTIRNIQPAAWPNLHMFLDDALLPNAILIEYIPNLQSIDLSNFSVKRLAKLREILDSIHQAQVLHGDPKPRNMMVSLGEYERVLWIDFDSAQTFSEGNLSPRQEKWIEEEVEMVDYFVNALAQDFEEGRLNRTISYYYDWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYE8</accession>
    <name>A0A5N6TYE8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_100014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYE8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="142" mass="16657" checksum="030E12BEE31BC393" modified="2020-04-22" version="1">MERHPRPGWFPKFQTSMNYCSLTGLLSGLLVLSIISYTQLAHSSLLSPFRSSIVLRSPDHLIRLGCGELWVRFLNSYLSRLLPLYFFSFPATIIYQLSHHPLHTWISHFSSFRSLYLSRSSFFITFFVYTFIYKCFLPFPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYJ9</accession>
    <name>A0A5N6TYJ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYJ9"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="505" mass="54922" checksum="A931A9868A40B6D2" modified="2020-04-22" version="1">MGYTTLWKRLSPSQVNLAIQTFSLVSVFFEGYDQGVMGGVNASPNYVAKVGIGRPDGTVTDTTHQGGLVSIYYLGCILGCFAGGWLADRIGRINGLFFGSLFALVGGALQASIQSSDFMLGARVVTGIGTALTGITPVLVSEVSPAKHRGGYPGYVFIANYLGISVAYWLSFGLSFINHGYSDFRWRFLLAFQCIPALVLAICVKALPHSPRYLAAVGRNREARELLSHLRYDKAMQNEIEQEYLEIVATAQYSKPSTPKWKVGQSLGRRAWLCLFLQTMASWTGITAVTAYSPVLLSQAGYSSIKQSGLAGGLNTIGIVGTIISAQIVDRLGRRKCLMLGSAVLFTVELIAGAVYEGSRRHPDRASTYAPAAVAMLFLFHLGYAATWGTVAFLLPTEIFPSDLRAQGNGFGITGWAIGVGMTTLVNPIMFDSIKSRSYFLLAGLNLIWIPIVYLFYPETCNRSLESIEALFSTPSPFYWDMELAYRLHGDVVVERDAEKGGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYT7</accession>
    <name>A0A5N6TYT7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742069">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF4">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        </location>
    </feature>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="578" mass="64318" checksum="7E7F51366FA75DAB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZI9</accession>
    <name>A0A5N6TZI9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_138617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZI9"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025059776" description="Amine oxidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="532" mass="59043" checksum="1889C409B925556E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZL6</accession>
    <name>A0A5N6TZL6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742064">
        <property type="protein sequence ID" value="KAE8151790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZL6"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="295" mass="31953" checksum="B3C56DF4F38BB225" modified="2020-04-22" version="1">MKRRAALGKHAAPAATGLDNYRYNELQNKTCLLDPDTIFGPYGIDGELHRHDVRESQKGIDLYLDLGVMDVETCEPLPDAWLSIWACNATGTYSGYTGINPDTVSVLDGWTTRSDGTTDDETFLRGVSKTNEAGMAEFLTIFPGYYESRTTHIHVTVQTNVTEDDTSYSDAAIQHVGQLFFTEDLINSVYQFAPYKSHLSTLNRTLNSEDSVYSVANADGYNAIISTELIGATLAEGLIGYITIGVNKSAEAINTTGESVNVQGYLPTVSLSASAQAAANTKDAAEGYKINGMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZN7</accession>
    <name>A0A5N6TZN7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_152168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742064">
        <property type="protein sequence ID" value="KAE8151795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZN7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="327" mass="35437" checksum="3E110B37ECA66C3B" modified="2020-04-22" version="1">MSNPIVLPRPGAASSPNKSQPIQAPSETHFTATFGNILPPATYLQTPNGQVAYYELSPSSPVPADQKSPITRVLFIHGVQTPAIGLQPLASALSSRFPHAQCVLFDLWGHGLTDTPVVVHDTALFHSLIESLMAQLGWKDAHFVGYSFGGSTTATFAAAHPERVASMVLVAPAGLLRSEQFDEAQKSYLEGGEGLEEKAQDWIFEFLEGGKLVVPSDWKERVNRGEVVAEAVRDWEVREHGGHVASVVGIFRDGGVLDRHAEFAEAAKRGVSSLCILGGLDDVCREQDLYEVGMQNVAVVPQVGHGVVRQRVPEVVQLIEKFWNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0G4</accession>
    <name>A0A5N6U0G4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_87815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0G4"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="342"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="551" mass="63255" checksum="BB823E3DF6E171A8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0G6</accession>
    <name>A0A5N6U0G6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_152043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
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    </dbReference>
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        <property type="entry name" value="Fe-only hydrogenase"/>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8151839.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="599" mass="64483" checksum="1998AA4D28F83860" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0I4</accession>
    <name>A0A5N6U0I4_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">BDV25DRAFT_170776</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KAE8152136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="59502" checksum="8A2E93CE3D333D2F" modified="2020-04-22" version="1">MTTVKRRRLLRGKITYSAAKEHETNILHALGYWDQQSQYFKDLHQKRHLIEALVAHHLNLGMKTCHIGEPAEWLSGTFNVCIPVFVNHSQRPGFLVRLPLPYRVGEAFNPGNADEKIACEVGTYVWLQRHCPEVPIPRLHGYGFSTGQTFTALENLPLLTRTVNLIHRRLLRLLGYELPSTYVAHKQRQNTLGVGYLLIEYIDQTRGRMLSESWHTGRHDTQLRTNLFHSLSSIVLSLSRTPIQEIGSFIINEQGFLRLKNRPLTLEIQDLENHRIPVDIPRESTYSTVDAYINDILAFHESRFRHQPNALNDIQDGLFQIAALTVMRTVRQAFFRPELRRGPFFLALTDLHQSNILVDDDWNIACLVDLEWACSRPAEMIHPPYWLTSQAVDGIDAAEYEKLHEEFMQAFVEREAVYPQTKLRLSRIMQDGWMRGTFWYALALDSPTGLFRIFYDHIQPRFCRGHVDDAAFFRIVVDYWEVGAFKFVLRKVDDKERYDRLLRDAFSLGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U164</accession>
    <name>A0A5N6U164_ASPAV</name>
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        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_170588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8152314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U164"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="74"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="527" mass="57966" checksum="9846FD21450E6A08" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3A1</accession>
    <name>A0A5N6U3A1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_48132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8153000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3A1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="83" mass="9623" checksum="80E56D1D84F5FB0E" modified="2020-04-22" version="1">MVEECVLEMESVSVSSGLAPRQVSSKGKSSMCIAVTQHSDVNFNNPIFTSFFLFSFFIIAFLLVLYRFWLDYCNLYQNGEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3P0</accession>
    <name>A0A5N6U3P0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_137149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3P0"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="509" mass="56399" checksum="B2A7B246F937057B" modified="2020-04-22" version="1">MRLINVKTYRLEEFFNEQIPPYAILSHTWGSDRDEVSFRDITEGNAKGASRWPIKLDGCCKQAEEDGLHYVWIDTCCIDKTNSVELGEAINSMFRWYKEATICYAYLSDVTVGSVEANNPHMDSEFSASHWFQRGWTLQELLAPRKLHFYNSTWKFIGSKTHIKLLHLTEKSLQAKQSERESSMHIKMHNLENTALSKRYTPVQPAKIRISDGKLITRHILTKDVQGPYKVAFSPDGRILASSGNYTRVILWHMITGKICRILTDHTSLVVCVAFSPDGRLVAAGASDSTIRLWEVASGALRNTLTGHNGLITSLAFSPDGRSLATGGGNVARLWDVATGTVLNMIRYDHYVESLAFSPNGKILAFGADVDTVRLWDIATGVVHNIVAKHGSHVNDVAFSPDGRFLAAGGLNAITLWDIEAREIWNRSELYTRVNSVAFSPDSKLLASGATDHTIKCWDVATGALRHTLTGHTGDLLSVAFSPNGGSWRLGLRPIQSDSGRSTPVDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3T9</accession>
    <name>A0A5N6U3T9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_150396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3T9"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="328" mass="34808" checksum="6037C5709D3075DA" modified="2020-04-22" version="1">MSLGIPRCFQLTAFRASFPSHFPAPSRPRLHPLRLFSPPVFPTAVRVKSTMADLVEAAKRAAGQAAVKNHYPKDAKYVGIGSGSTIVYVVEAIKESGVDTSMTKYVPTGYLSKQLIVSNGLTAVDFDSLPEGTVLDIAFDGADEVDDELNLIKGGGACLFQEKIVALQAKEFICVADSRKLQSRLLSNWKYIPIEVAPIAASRVLKELQEIGSIAPAIRLNPTAPDGAPKSTPLKTDQAFNIIDAPFKTLLTKADVLAGKDGSGKDGIWEVEELSRAIKRIPGVLDVGIFSGETGPQAQARGGTGGQKPVAAYFGMPDGSVSSRTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U445</accession>
    <name>A0A5N6U445_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_136938</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="385"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1282"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1635"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1714"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1718"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2551" mass="282728" checksum="8D3001037FFC37F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4D2</accession>
    <name>A0A5N6U4D2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4D2"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
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    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="216" mass="23821" checksum="88C3F02A50656198" modified="2020-04-22" version="1">MPSILEDPSTKIPPPTKLPPMLSPRKTHLKDQTPVTLYPITNGASALPHELVSLLHREFTAEIEAGCTYPMEEPMDLARFAEYWFGTFAVVAVVDDEGEGNGLRQGRDWERVCLGTFYIKPNYPGRCSHVCNAGFLTTGAARNRGVGMVMGKTYLEYAPKLGYKYSVFNLVFANNVASIKIWDRLGFTVIGRVPGAGRLANSEELVDALIIGRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4I0</accession>
    <name>A0A5N6U4I0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_149441</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4I0"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8153420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="352" mass="40331" checksum="1300188312949579" modified="2020-04-22" version="1">MNTLTATVPLRATSLPKSYLYLAARGYTAVATTGLRCSSPLLAKPYRHQETKRFISSTPPSQIKEYFPPPTAPHIKEVETAWVHPVYTEEQMHQVSVAHRDAKNWADWVALGTVRLLRWGMDLVTGYRHPPAGKEHEAKFQMTEQKWLTRFVFLESVAGVPGMVGGMLRHLRSLRRMKRDNGWIETLLEEAYNERMHLLTFLKLAEPGLFMRLMVLGAQGVFFNGFFISYLISPRICHRFVGYLEEEAVITYTRAIKDIESGSLPDWTQMEAPEIAVQYWKMPEGQRTMKDLLMYVRADEAKHREVNHTLGNLNQGADPNPYSVKYKDPSKSHPGKGIQNLKATGWEREEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4L2</accession>
    <name>A0A5N6U4L2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_24514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4L2"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="274" mass="30514" checksum="3817FDFEEA0B1ACA" modified="2020-04-22" version="1">MVQNQPKIRQRDDEDELDLLDFIFAQPNREEIQGNPQKVLDLIDEFGKERHLIHVGVGKGRVVTDLIAERKPQAMIELGGYVGYSAILFGDAVRRAGGKRYYSLEVNPEFAAIATLLVDLAGLRDFVKILVGRSDQSLHNLYSSGEVPQVDIMFIDHYKPAYTTDLKLCEQLGMIVPDVSVVIADNVLYPGNPPYLEYVRSTVEQKRLAAEKGPVQIYNTEGIPERSVAVFLGKDSAPLFEIVGNPNLVYESTLNQPEGLRDAVEITRCVGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4P0</accession>
    <name>A0A5N6U4P0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4P0"/>
    <dbReference type="OrthoDB" id="4429574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025068271" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12380" checksum="767F8F2FDE5D974B" modified="2020-04-22" version="1">MRPSSLFILATALVPFAFARFSGGPVSASLEYSLKIDSSFPGLKPDLAENLGSLYIDEGASCELFEDLHCDKYLLEVEAPGEDNLFNSGVGYVSNSIRCNYASEAWVYRQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4X7</accession>
    <name>A0A5N6U4X7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4X7"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24769" checksum="D5DC90FA37C88D30" modified="2020-04-22" version="1">MGKSQPYLQEHIASGAPSNVGHPPPLWGNPQYPPQPHHTQAPSRSFQVAFTSWTTRHISVTEMGPIGSAIYTVDLHTRKPQMIFKLGTADAPYVTVEHRTMKTEVDIHFPGHKITLPIKARLKYKTTFASHALPNAQWTWRSTGAMKFLDFECTDQNSMAVARFKPASTWSMHKMGQMELVGPVANGGPVFDEVMITGIAFAYYVYLTHMGAGGTAAASASAAAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Z6</accession>
    <name>A0A5N6U4Z6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Z6"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024942892" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="41664" checksum="F263AB0F08476A21" modified="2020-04-22" version="1">MLFPLAWVLVPASLAAQTLSHDNPTIYQNDADLDTHRILQRNAAIQEQLSQAPAQGMKKMTDDEGEKFLLDYWFFESNSTDRPDTKEPKTTETAFHPRSYPDEPSAPLDNSTALDGWMGPISPLLRRDFQCPSGTYSCTSINRPDSCCSTGSSCELVQDTGSGDVGCCPSGQQCSGTIGSCKPGYTSCSASLGGGCCIPGYQCVTGGCAKVYTVTITVGSTVLVSTVTSTVPATSTASRSSTVNTWAPTTGEFTPPARPTSLTTATTSQTTGAFCPIGFYACSAVYHGGCCRTGRDCDTTSCPQTPSTTITTNDRTIVVPAPTPTIGRCASGWFSCADTVGGGCCPTGYACGSSCTAVTTATTTGTVAKGQPTYSAADKRMPARLKILGMSVVGLLWTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6C9</accession>
    <name>A0A5N6U6C9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_148416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6C9"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="115"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="559" mass="62277" checksum="39398FDBDE07E4E9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U6N5_ASPAV</name>
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="118" mass="13510" checksum="E30A7C4BFF0D194F" modified="2020-04-22" version="1">MTELKEKLPLETRTREVTSTCVHETSPTPHLDHEFQQPQSKQILQAVIAALSDIADEHRCTTCAVETSSRLLTGYLREVREAKKSGKWSKEERKAMKKETKMLASVMKRDVGGLWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U891</accession>
    <name>A0A5N6U891_ASPAV</name>
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        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_147105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U891"/>
    <dbReference type="OrthoDB" id="5329488at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
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    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="246" mass="26030" checksum="2B2C40FC6798E87D" modified="2020-04-22" version="1" fragment="single">MKTSQLLSQWIAILLMGVGVAQAHTVIVYPGYRGNNLHTNGTVEEANGLGAAMSPNSTSNHSMIYPYGQQWIYPCGGMPTSTNRTKWPVGGGAVSFQPGWFQGHSTAFIYINLGLGTVPPNMSHPMISPFQIEGPTNDPYPGTVCLPQVPLPADVKVSPGDHATIQVVETAKHGAALYNCVDIEFAEPEDVAEVTRDNCFNSSHITFASVFASTSLTSGASSIDTSRTLVTTLGPAVLAGVMGFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8M9</accession>
    <name>A0A5N6U8M9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8M9"/>
    <dbReference type="Proteomes" id="UP000325780">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="261" mass="29281" checksum="B18C541A0408A54D" modified="2020-04-22" version="1">MKGMRDIRHQVETEPMRNSGSGTVLLITGQPTARTAQASFVLRDQKTDRFSALPVALMGRLMVTGPAMVYFVSTHTLRPQTLHHTISYVLSFSKKHENSFETAPLVPLPSISLTAIYNWYFSFSRAFNLYSLGSEKAEIGLEKPTILSLFDPGISVSKVFLNTILEDQKTYWRPPLIAPNLFDQSDDTADRDQDILDFHQDIENGGEAIVDPEERRRGQAQEVEALFDETGHRGHSGSGRLETLVEAELVVEVEVDVEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T2</accession>
    <name>A0A5N6U8T2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8T2"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="240" mass="27065" checksum="B347A66B2662564B" modified="2020-04-22" version="1">MREAQLETPTKSTGNLPGFSGVEDTPDAGDSPFHSPGPVEITHLMYPQTKDEQIVNTALVDFLNALTMHFPQANDWTLHRKSFKAAFQHASFEARTDGYLEDDGSSDRVRALIEVKPMLREKKRNPICMQEAAQMVAWIKSDPDPRGVLNLPGRRLHVSQDRHQIFITFAEYDSSYIQYLNNTLPPDSPRPFLKMHEFGPWNTMVKNDMENIGSILLAIALRAYSDANPGKPSTSEQHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Z3</accession>
    <name>A0A5N6U8Z3_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_147157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8154889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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            <end position="79"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="706" mass="79579" checksum="30757851EE816844" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U971</accession>
    <name>A0A5N6U971_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_135212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="291007at2759"/>
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    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="159"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61642" checksum="9D6C54354F7A9973" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U998</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="10">Sensor histidine kinase/response regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="565"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126559" checksum="AC0174F7091F8978" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9L9</accession>
    <name>A0A5N6U9L9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_146474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9L9"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="183"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8155313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="422" mass="47238" checksum="6016A37B27E92F6C" modified="2020-04-22" version="1">MMFFGVLHRVYAGFINPPPVKKNTDAIRFGLLGASTIAPVALINPAKSHPDVVIAAVAARDRTRAEAYAKKHDIPIVHSTYEELLQDPCIDAIYIALPNNLHYEWSLRSIRAGKHVLLEKPSCSNAEEARALFNHPLLKAAGAPVLLEAFHYRFHPAWQAFHARIHSDPEAGRVKKAFAEQYLPKGAIPENDIRWRFDLAGGAMMDFGTYTMSCLRQIFNQELVEVVDANPQSLAASPDVDRAMSASYRTADGATGTLVADLSASGGWPLLASSWTKSLPRLGWPKCEAELEEQTLESSEGQVHTVKRNVTMWNHLAPSIYHRVDVEDTHMIRVGTQVVKSWKETKREKAYKWPSGQSQGEQEWWTSYRYQLEEFVNKIKGRNGSGVWVDAKDSIGQMEAIDATYRKAGLRVRPTSDFDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9N6</accession>
    <name>A0A5N6U9N6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9N6"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF19">
        <property type="entry name" value="CATALYTIC_ HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="76"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="33498" checksum="77998539F33B3817" modified="2020-04-22" version="1">MSPKQYPYPIVDVWANIPGLGTAIPEVENLFTYSHSDPEWANRRRSPKELVSLMDEAGISHICLSAWSRPGKMIFSNEEVAEYTRAYPDRISGLAAVDLHDPVKGVQELEHYVKVENFKGLRIVPWLWNLPPTDARYYPLFVKCIELDIPFLTQVGHTGPLCPSEVGRPIPYIDSIALQFPQLKIICGHVGWPWTAETVSVAWKHQNVYIDTSAWSPKYYAPEFLTFANTTGRDKVMFATNFPQLHFKDCVRNVHEHLLDKGVLRRSSLEGSMGGNAIRVLKLPVKVESDATKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCR6</accession>
    <name>A0A5N6TCR6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherulation-specific family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742698">
        <property type="protein sequence ID" value="KAE8144178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCR6"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="302" mass="33694" checksum="EEB2C2C146926EC7" modified="2020-04-22" version="1">MAAMGLDKHVNGRRCLQSRRSRIILGVFVFIAILAVVIPPAVVVTLRKKNGMGPKANIFVPLYVYPAPGAWDPLEQEISTHPEANFTVVINPGSGPGPDALPDANYTREIPKLASYDNVRLLGYVATTWAKRNISAVRRDIETYAQWPTNSSNPKIAVRGIFFDEAPQQYDEDALSYLQELTTLVKSLSGLGPDKFVVHNPGAIPDSRYMSTADSTVVFEESYDTFNERNGTKQFEVLPNNNRSQLCIVIHSVPDQVEGSKLKDLVKKLRKTADEIFVTHLTTDYYANFGGRWGEFVDWMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCV7</accession>
    <name>A0A5N6TCV7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742653">
        <property type="protein sequence ID" value="KAE8144214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCV7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024872213" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8862" checksum="C27E3F46D1953BE2" modified="2020-04-22" version="1">MRMTLNLRFEWALLCAGLTLPVCGPEAQFWKLCCARETRLSTFRFSDYSFSMEIQSCMYILACILCTLPTYRLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD55</accession>
    <name>A0A5N6TD55_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_145746</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="ML742571">
        <property type="protein sequence ID" value="KAE8144315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD55"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025090425" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="346"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8144315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="513" mass="55677" checksum="B231C581DB16297A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDE8</accession>
    <name>A0A5N6TDE8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_167187</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="ML742586">
        <property type="protein sequence ID" value="KAE8144286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDE8"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="303"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="575"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="640"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8144286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="778" mass="87208" checksum="F2812BD58E322171" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDF4</accession>
    <name>A0A5N6TDF4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_145964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742736">
        <property type="protein sequence ID" value="KAE8144161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDF4"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="471" mass="53693" checksum="7BA58629B491E81A" modified="2020-04-22" version="1">MQEQARPYRSHKIPACDRCRRFKRRCTGGTSERPCVLCDLQEVPCVKSSSPSATTRTRRRVKQDRRHVLPPKIAPAHAVPAIPGDDETAHIGRDYHSSAHQDKSKKELSMLAGPVISEDIQILERYMSNTMSSTEVAPLPVTSTPANPMVYLRVPRRREGLAMAENPGKRQKEILMQILQPYADELVRLYFEESHMAFPILDEQLFLELYKSGDKLSPVLTCDFFAFALILWHHSPVLRQFPKPDAYFIWNLAVEALQQDFLAPGLSTVYSVIMDMTGRPVISMLGNTINNGRAVILAQSLGLNRDPTNWRRSKSEKSLRIRLWWAVVIHDRWSSYAHGISPTITKSRYDVPIPVLSDILTGPNQSEKRLKSAQSFIHLCTLTEILGEILPLVYDLNTDHTDWNQITRLQSDLDNWESNLPEYLRRDTQTKTQRVCGSSNLQLSYLSVRLLLNRVSLHVCPCTTHPNSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDK9</accession>
    <name>A0A5N6TDK9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742512">
        <property type="protein sequence ID" value="KAE8144468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDK9"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="337" mass="35985" checksum="1046A66BF430EE38" modified="2020-04-22" version="1">MTKMCPDINSLPPSRSSSASPRQARNLPTSSDTQHSSSGFSPASATMSNINSQTHQDHATELPRRLSRSSRTGGPGPERRRSAAGANSNVNNNEPTGDTTAPSDHRSSLGHHALRTSSPSSLGGSPIIATGDPHHQRAPSLGELHQELEQEQEAQVNRLLHMIRSQQAQLEQLQHHHQRQGSHGTAIDDSDRSTFTTIPPLSGAGNRNSTQLTSSLSSRRPSRPSSQAASPSLRPVADVPRPEGSEWITGTSESPARRSSRDEGAFYQAEATMLSRENQMLRQRIRELERQVNELTVSSGGGRSGENPAPPATVGGQNADPQAAGGVGLTSEHTDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE51</accession>
    <name>A0A5N6TE51_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_166426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="ML742475">
        <property type="protein sequence ID" value="KAE8144612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE51"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="112"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="358" mass="39727" checksum="8DF912FB3A26FA1F" modified="2020-04-22" version="1">MASESTTISNTENLMKYMSLDQRGNIQAEYIWIDAVNGCRSKTRTISKPVSSVDELPEWNFDGSSTGQAPGDNSDVYLRPVAIYPDPFRRGDNILVLCETWDSDGTPNKFNHRHEANRLMETHAKEEFWFGLEQEYTLLGTDGWPYGWPKGGFPGAQGPYYCGVGTGKVYCRDIVEAHYRACLYAGIQISGINAEVMPSQWEYQVGPCDGIAMGDQLWMSRFLLHRVAEEFGVKISFEPKPIKGEWNGAGLHTNVSSASTRADGGMKAIEAAMKKLESRHVEHIAVYGEGNEERLTGRHETGNIDKFSYGVADRGGSIRIPRQVAKDGKGYFEDRRPASNACPYQITGIIVETLCGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFR9</accession>
    <name>A0A5N6TFR9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_170685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742371">
        <property type="protein sequence ID" value="KAE8145214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFR9"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="275" mass="32590" checksum="23FAA12F0D321F27" modified="2020-04-22" version="1">MPLMYRCKSLKARSKASGLLRLPAELRWQIYQYLFVPCRVEIVRTKNKSDDARKPAHWRLKHQRMRPREPNSQKPLASRNRRDKWPSPMINLVFSCRTIYCETVLLLYSTTQFVFNSTNTVKRFLKTTTADAQSVVHHVELNHTMYNEPHLMEFREYKIRSDIAWYDACDQMAASFSTLKVLHIKLAINDWPIRLELGELWSMPLLQFAHYDGGLDYTGVQLQMKMFKDEKLRAVSRALEKKIMNPKKFQIREDEEMAWELMKSVKATKALRVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG18</accession>
    <name>A0A5N6TG18_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_164944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742359">
        <property type="protein sequence ID" value="KAE8145318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG18"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8145318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="438" mass="48816" checksum="FEDB3D04399FDC1D" modified="2020-04-22" version="1" fragment="single">MPSATGTNWEKYQKNFADDEEPEKKITPLTDDDIQVLKTYGAAPYANALKKLEKQIKDKQASVNEKIGVKESDTGLAPPHLWDVAADRQRMAEEQPLQVARCTKIIQDEKDSDKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQIMLPLPPKIDPSVTMMTVEDKPDVTYGDVGGCKEQIEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDVEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVATEAGMFAIRARRKVATEKDFLAAVDKVIKGNLKFNSTATYMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG36</accession>
    <name>A0A5N6TG36_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_170631</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17 18">IBT 18842</strain>
        </source>
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        <text evidence="3">Belongs to the LCL3 family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9 17" id="KW-0255">Endonuclease</keyword>
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    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
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        <location>
            <begin position="82"/>
            <end position="249"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_144757</name>
    </gene>
    <organism evidence="3 4">
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="413" mass="43099" checksum="973668AF4D28E129" modified="2020-04-22" version="1">MLNTDCPSGKEFYTCAQGPYQGCCSSNPCHNNGICPDDDSSSTTSKPTRTTSRSDTLTKLPLPTFVPVTSTGSTAPSTTSVTVLTTITNSASKASSSSSATSAKTSAAGQGAGDSDGKPSVGAIVGGVIGAIVCLILLLLVGLFVYRRRKRYKGKGPSSPTPPSDAAHAEQAIHAPTKQEKTDMGSSILTPTEFSTTGTTPISPSSPTAELDGSHPHHHRNSPLDLVIHESASASELSDTGVYRTRAELAAHSYRELINVPAHQRQPSNQSLSSLPESDASPAELASQSTRELINRQRPQPSTHQSPPTPQGQSQGQGQGQGQEKAQAPTTPCAPIITADGVVLTANFDTSAPDSLAAEARTSHAMSFMDYDASRKSMLQGYGPDSKGAIREEVPDLPKLSSKEKSDPSISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGC9</accession>
    <name>A0A5N6TGC9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centromere protein Chl4/mis15/CENP-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742350">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="477" mass="52398" checksum="C294BD38B0626A9C" modified="2020-04-22" version="1">MVRPKSIRAPTTASLPSNLLIPSTTPSLVKALGKLPRQALLDLVFHWLDDRNVQLFAPYLESDEADNAEDEGLGPYPAERTIDDVRNAYQELQVRKGGKREVVDRILEGDWRHGVTLRQLAMVDLRYLDNHPASLRWTALELTRIGADGGESSLTDGLACVPRIHASTFLNNVQQQISPLVKAHYYLARSHSLPLTFLRIFVTTSPYQHPRHSAETLTDSSRVIYVAFPDSSPYVYTSIASSSSSRSSTNAFATDVRSLQRIVRDAIPKALSLPQQRYALKATSLTAKNLQALLALRGPGRSNRANGAFSIFADAVADGSPLDPRPSNTVPPEELINQSKLEAPAKDTESRKENDSMTQPSGKRHRDSDTDILIPPKRKVAIHSRFGTSGYLSSASLDRFDVRILDRPQSDDDDEEADSAQPTVSLTFAGSDVIAGIRKLAELGIVDPERMPSWMTGEEGVSVAVVRQGNRVVKDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH57</accession>
    <name>A0A5N6TH57_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_66074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742323">
        <property type="protein sequence ID" value="KAE8145666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH57"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="387" mass="43079" checksum="B97D3E909390025D" modified="2020-04-22" version="1">MCRFLVYKGRHEIRLSKLVTEPSHSILTQSYDSRLRLDNRRPVNGDGFGVGFYTDPKLGPEPCIFTSTLPAWNCENLERLASKTCSNLIFAHVRATTEGALSDNNCHPFQHQTLMWMHNGNIGGWQYVKRTLGDSLADKWYLGVKGGTDSEWAFALFLDLLEKEGVDPSSDPGPEGFGQALLRRVMVKTIAKINEFIRDIPKRHNVSGVETRSLLNFAVTDGHTVVCTRYISSKTDEPASLYFSSGTKWKEGKVKGHFKMERHDKGADIVLVASEPITFERHNWVSVPANSIVTIHNQTVLLHPIMDEFYSEDLNHDRSSCYAVSKGLVSTAPGTTVQPPKADEYNRAAIANTKPPVISVNGSRLDDCAGGLPQHTQDYANQCAMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THQ2</accession>
    <name>A0A5N6THQ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_163606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742303">
        <property type="protein sequence ID" value="KAE8145898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THQ2"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="342" mass="37357" checksum="380BDDDD5EEBBC9E" modified="2020-04-22" version="1">MAADIPKVVPLTCHGHSRPVPHISFSSTVEDDQYYLISACKDNNPMLRDGITGDWIGTFLGHKGAVWQARLSTDATIAATAAADFSAKVWDTHTGECLHTLQHSHIVRAVAFPIQPSPQVVATGGYEKKLRIFDLSRSNSNSNSSSPTFPTPGENGASAQSVTSYEIGPGVHGGTIKSIIWNQDYNILTTAAEDRKIRWWDLRSRHPVIEYTVEGPIGSCELNTLATRQNDPGILTVAAGKSVYLFDGANPGRLLKKSDFRYEVASAAVNNDTGKLVTGSADDTWARVYDLRTDEELEVQKGHHGPIWSVSFSPDGKIYGTGSEDGTIKLWKACREPYGLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THW0</accession>
    <name>A0A5N6THW0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_170413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742322">
        <property type="protein sequence ID" value="KAE8145681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THW0"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="103"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="628" mass="70825" checksum="1C8BAEFDC64EA703" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TII6</accession>
    <name>A0A5N6TII6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742282">
        <property type="protein sequence ID" value="KAE8146163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TII6"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52567" checksum="0A72EEF97FF93D4D" modified="2020-04-22" version="1">MIQFRPHLPWKMVSPDHRIILCPGTREERQYVDLFCNQTTRALSGFFSPQLWNYQLPQLSHSEPTVRHAIAAISAAHERNFLRPSAENSRSIEQFMLQQYNKSIRHLMGHLSDPKPQSADLMLITCCLFVCLEVVRGNNKQALDHLTAGATFLNRREYVAKKTAQYTDIQKELSHLFFRLNLQLSLFGRPLVPVGNGLRALSSFLREGSISFVDLEDARHCLDALMNQTLSFVLSVHTGGLPASDAVLKQQKQSQLDLLQEFHCWSTAFDQLIARRGTSKTLDKRGPLTLRAHHRVSQIWMQSCMSKDQMVFDNFNADFEAIVNLSEEVVRLSSGLDRQCNTVGFSLESEITAALWFTGIKCREPIIRRKAVRLLSDHHRQEGMWDMGLFAKVAGLVMQLEETELSSLPIAKRVPEDHQRIYDPILPEDIVTSPCQVILLSRPYGVDGELHSEVKYVSWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIN2</accession>
    <name>A0A5N6TIN2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldo-keto reductase ausK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_162945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742279">
        <property type="protein sequence ID" value="KAE8146205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIN2"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19147">
        <property type="entry name" value="AKR_AKR9A3_9B1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000024">
        <property type="entry name" value="Aryl-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="42926" checksum="5E78A77AA47581F9" modified="2020-04-22" version="1">MAELFKPAPEPATELGRYRILSSTAGIRVSPLQLGAMSIGDAWSEFMGSMDKESSFKLLDSFVEAGGNFIDTANNYQNEQSETWLGEWMTERKNRDQLVLATKFTTDYKTYAFGKGNVPNHCGNHRRSLHMSVRDSLRKLQTDWIDILYLHWWDHTTSIEEIMDSLHILVEQGKVLYLGISDSPAWVVSAANTYARAHGKTPFSIYQGRWNVMIRDFEREIIPMARHFGMALAPWDVLGGGKFQTKEAVEERKKKGEGLRSIMGGKEQAEEEIKMSEALAQVASEHGIKSVTAIALAYVMHKATNVFPLVGGRKVEHLHDNIRALKIKLTPQQIEYLESVRPFGVGFPNDFIGPDPKVTGQATGLLGATAPYAFVQSPKPITPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIN4</accession>
    <name>A0A5N6TIN4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_162957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742280">
        <property type="protein sequence ID" value="KAE8146192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIN4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="56" mass="6127" checksum="07DFE3B68E321D94" modified="2020-04-22" version="1">MRLMSNPSFGSQMTQVSGCQRNTITLFVPRSLPAYIMEKAFLYPAVGLAIGLQYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIW5</accession>
    <name>A0A5N6TIW5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA splicing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_144085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742291">
        <property type="protein sequence ID" value="KAE8146039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIW5"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="395" mass="46947" checksum="2B039DECC2468022" modified="2020-04-22" version="1">MGGDLNLKKSWHPSLLRNQERVWSEEKRALEERKKLDQLRRERDEERQIQELQRLHEDSGKPRQHNRVDWMYQAPSSATGHYSEEMEGYLLGKRRIDGILLKGDESRKLVRGSDSIGSSSGGGGGGGGVNSRDMMSKVLADPLMEIRRREQAAYEGAVREAASKGRAEGRERGKSHRRERERSRSPRSSRRDHRSSHSHSHSHRERRGDRDRERRDRDREDRRDRDDRRERDDGYRSRQRYDRSRRDSARDRSPSLRDDYRRRSDRDSGRDGNYSRDHGRDRSYRPNDRRDNRGPRDSYPRDRPRETARDDNKKDLEEERKRKLAEMQSNASDIETTRRQRIADVSAQEEKQREEDEKQRSEKGRFVAGLHRQLQEDSLDDRIKRNRGGLTRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ78</accession>
    <name>A0A5N6TJ78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_51971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="ML742267">
        <property type="protein sequence ID" value="KAE8146377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ78"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="63"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8146377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="430" mass="46423" checksum="5D5872E814F8F3E2" modified="2020-04-22" version="1">MPGKTTTLPRITKFTNCRIIRGNELVEQDVWIDSLSGKILRDQEAFYELHISPDEVIDLDGRILAPGLIDVQLNGAQGFDFSVPKSSKEEYDEGLRIVNKGLARTGVTSYLPTVVSSAPEVYWKVLPSLGPSGPKHRAEDGAESLGAHVEGPFISPGRNGIHKTEVLQATEEFEDVIQCYGKANISGDSKTVKMITAAPEIGSMVNHIPSLAAQGIIYSIGHSDASYEQAMNATKQGATMITHLFNAMRPFYHRNPGIFGLLGQNERPRPFYGVIADGIHLHPTSIRIAYNAHPDGLILVTDAMKLCGLPDGVYDWTNGERIVKSGARLTLEGSDKIAGSSATLIECVNNFRRWSNASTAEALNAVTATPARLLGLEGVKGTLESGADADLIVLTDALDPYSGPTLTVDQVWKRGVKIYDSGKAAVNNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJD9</accession>
    <name>A0A5N6TJD9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_54590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742279">
        <property type="protein sequence ID" value="KAE8146209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJD9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="145" mass="17126" checksum="D69634025BDBB2DE" modified="2020-04-22" version="1">MAFLWLPHSLLSLFFFFLSFPLSYRFTLWLPDPTRFSILLSRPVDSDTHTFLVYTGVMPLFVFVLPNSFKHMLLKFHGGDHCSFLFKQRHQEIANFKFKVSMRFIILIHSVSYLVNSSQHCGFFDTQLLQDDLKARRTIHSFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJK8</accession>
    <name>A0A5N6TJK8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_169834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742257">
        <property type="protein sequence ID" value="KAE8146527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJK8"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="257" mass="28485" checksum="0820B496DA2B61F3" modified="2020-04-22" version="1">MPPKPAPWRPLFATHLSQSTSFTLSTITRDPKGKIVPRSRTCQLRGFWPTPSLHPSAVEALKSQGVGLNPDVYESDMLSLTTDIRMEKAGQIRASGAVEGMFWVGGVGNQWRVKGEAFVLGGVFGDGQWEEESRRGVLEGMRVVSSHDDGGGGGGGDGEGWEWERQVTAYFANLSPVMRGSFKNPPPGTPRSEEPGPGLDLGQTVDDLRDKIARRNFRVVVIRPEEVERLDLSDMQNVRRVRWTLDGEDWVETELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJY9</accession>
    <name>A0A5N6TJY9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_162483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742263">
        <property type="protein sequence ID" value="KAE8146429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJY9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="83" mass="9201" checksum="B23EE3D7C01C3753" modified="2020-04-22" version="1">MQIGLAPLRLVELSGLVNSWHLALSSAIYLVSHKFCGRIISCDALVNKNVAPCCANLTSPKKKRKKKKDNHLIGLFDDRLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK83</accession>
    <name>A0A5N6TK83_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742244">
        <property type="protein sequence ID" value="KAE8146747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK83"/>
    <dbReference type="OrthoDB" id="3549121at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="43464" checksum="D097032ACCC15966" modified="2020-04-22" version="1">MGRTVDQEVHAAFVEFRAKEDDKCLSVQCIYCQQIRAKNTSRQKQHLLECPGLRGHTNPQAQSQSAPSAPNGIGAANGYPPPTPNGAAATAPGAGPGPGALSTPSAPMMTNGVNPHATPMQTPLQNMQGRASLPTSGPAGTSAAPPAQQAPRATPKSKPKNSNSNLPAPPLDDVHAAFVEFRAKEEDKCLSVQCIYCQQVRAKNTSRQRQHLLECPTYLSVMKDSIPANNLLHTFPEGDVARSLQIPAPTLELDFRMSIKMNPRVAVGQSIWGQRDWVTFVGGQWAGRWGKGIVLPGGQDSQIVTKESATSLRASYMLQTADDPPAFIIVKANGWLTGAKDVLDKVNDPNVADTINPNTYKYRINLSMETGDERYAFLNTLMWVGSGCRRGHEVIFDAFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKE2</accession>
    <name>A0A5N6TKE2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy-related protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_132608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742240">
        <property type="protein sequence ID" value="KAE8146828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKE2"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="200" mass="22679" checksum="18C1718CB40F809A" modified="2020-04-22" version="1">MAHWKEEYSAALAARDRREKSNNAILNAYTKLADRAGLIATTADDGAQSSESHRQSPAIDSKKQPPGSPGPSLQDVLAATRLDLTEAQRSRSELQDRLTRTTAELEKSRKRGSQDSRRIALLEREASQLQLRLRDRDEELRGKAKLLDDFQDELASLNLQLNMAEERSNRLQKENQELVDRWMARMGKEAEAMNEASRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKK3</accession>
    <name>A0A5N6TKK3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_143253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742237">
        <property type="protein sequence ID" value="KAE8146888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="766"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1859"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2962"/>
            <end position="3040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2936"/>
            <end position="2959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2946"/>
            <end position="2958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="3468" mass="380327" checksum="6A0B6E000E29FCDC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKQ7</accession>
    <name>A0A5N6TKQ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase II-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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                <person name="Machida M."/>
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                <person name="Nybo J.L."/>
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            <strain evidence="5 6">IBT 18842</strain>
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    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="33562" checksum="73B584478F32C867" modified="2020-04-22" version="1">MTSFTASSLNSISDTFKLNGLTTLTTLSFGSLTKVGSIEFTALPNLQSLDFTKGVTEAGSVSITNTGLSSLNGISLETVGGFDVTENTALKSVNVNNLKNATSLINFAGNMDSLEIEFPNLATGQNMTFRNVSSVSVPSLEKLKGQLGFWGNKFKSFSAPNLTETSDLIFDNNAKITNISMPVLKTVKGGFQIARNDKLDSVNFPKLETVEGAIDFSGEFNEASLPSLKSVKGDLNMQTTGNITCTAFDKMKSDGVIKGKKTCDAKAKDPKTRDGKSGSSTTSSSSSSSTSTGAASFVDPASMPAMGMAAVFGALLQYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLE8</accession>
    <name>A0A5N6TLE8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_40498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742226">
        <property type="protein sequence ID" value="KAE8147100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLE8"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="79" mass="8404" checksum="D6DBC0832FFD521C" modified="2020-04-22" version="1">MSEHQYKFNITMSCGGCSGAVERVLKKLEGVKSFDVSLDSQTATVVTELPVSYETVLATIKKTGKTVNSGEADGQTMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLI6</accession>
    <name>A0A5N6TLI6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_36781</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742219">
        <property type="protein sequence ID" value="KAE8147208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLI6"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17322">
        <property type="entry name" value="MFS_ARN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000510">
        <property type="entry name" value="Siderophore iron transporter mirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000533">
        <property type="entry name" value="Siderophore iron transporter mirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="66"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="615" mass="67520" checksum="42A2DC872DFE7B99" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLU3</accession>
    <name>A0A5N6TLU3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_132184</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLU3"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000029">
        <property type="entry name" value="Mitochondrial intermediate peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="285"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8147323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="779" mass="86835" checksum="CAB61FE7849E8775" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLY0</accession>
    <name>A0A5N6TLY0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator PAI 2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLY0"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="259" mass="28494" checksum="7C043B3323B865DB" modified="2020-04-22" version="1">MYLRAIHAETSTKALFELIQNNPLGVITTAIPSSAHHFIQSSHIPWVLDVISEDPDAPVKGVLRGHMAKQNPQAKAIIESLNTAGLPSASSLQQEVQILFTGQYHHYITPKFYTETKPDTGKVVPTWNYSAVQVHGKAKIYHDGASPETSEYLSKQIHDLSQLCETSIMGYTGQNGAKDSWKVSDAPDRYIEIMKKNIIGIEVTIEDIGGKYKMSQESSKGDREGVIRGFESIDSDVALNMAALVLERGKIKDAAKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM37</accession>
    <name>A0A5N6TM37_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cnl2/NKP2 family protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742208">
        <property type="protein sequence ID" value="KAE8147416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM37"/>
    <dbReference type="OrthoDB" id="2311687at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="195" mass="21223" checksum="8AF1CD7201D6872B" modified="2020-04-22" version="1">MAPSEASILSNFLLSPASLPTVISLQQFTELFPKRLRSHPHIRVLYRELQQLREQDMDLVNGNIDRELHQGDSLKAELRKSILKSGVDGMSVNDQREMDMDVQLFGQASTSSKNYHSTSSLLSAMEAACAGIEHETANVDGSATTLLSELNGTVGELSDLRYGKMQGPATAEDVVSGSIEGLQHLEEACYGKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMA7</accession>
    <name>A0A5N6TMA7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_32972</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742206">
        <property type="protein sequence ID" value="KAE8147474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMA7"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="302"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="666" mass="74859" checksum="14229E63FDECB0DA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMB9</accession>
    <name>A0A5N6TMB9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_36318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMB9"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="17645" checksum="7374EFB4F30CA235" modified="2020-04-22" version="1">MNPHQQNKVDLSSLSPDEQRLLRLYGKMPTKKDLLQNKLKERKYFDSGDYALSKAGKASDVGVTNIGSQHPVPENIPHLTATSPGANNAAAANNGGSASFQGQQVPGSISGHPGSIGFQSRSPVKEASYLQRGTSADDSEADTGAPNNEDEPSVSPPPARDGVPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMD2</accession>
    <name>A0A5N6TMD2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_33213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742207">
        <property type="protein sequence ID" value="KAE8147450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMD2"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="179"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="519"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="889" mass="100854" checksum="8A0DC389FF50B5F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMH8</accession>
    <name>A0A5N6TMH8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_160062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742201">
        <property type="protein sequence ID" value="KAE8147562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMH8"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="543" mass="61089" checksum="DA27260EB45EB6C9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMM4</accession>
    <name>A0A5N6TMM4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_160501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742211">
        <property type="protein sequence ID" value="KAE8147359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMM4"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8147359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="187" mass="20984" checksum="4590703615DE5FA5" modified="2020-04-22" version="1">MPTAPKQRKIAIVGSRSVGKSSLTVRFVEHHFVESYYPTIENTFSRIIKYNGQDFATEIVDTAGQDEYSILNSKHFIGIHGYIIVYSVASRQSFDMVRVIRDKILNHLGADYVPLVIVGNKSDLKTEQRQVSSDEGRTLEEEFHCAFTEASARLGYNVEKSFDLMIGEIEKSQNPSQPTGGNKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNC4</accession>
    <name>A0A5N6TNC4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNC4"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="179"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="393" mass="44734" checksum="724603D4D482AF70" modified="2020-04-22" version="1">MIAADNSHLDNAALPSGDSPELVLVPATPEERIESIKLNSVVWKGALDLDTYLARENHLHQQALVKDGLDIWLLVVRGEAENQRTILASCETYKKKAVLAQDGNVEPISAHGLGSVYCRPEFRGKGYAKRMVSELSKKMDTWQTETILANRSRFSVLYSDIGKKFYAQFGWKPYPSAHFSLSPLSKNEHDRAITGVSLPKAKTLVADDVRHSMCNDEIVRKELGLLRTVSQRSPGAKVAILPSFEHYKWHWAREEFLANILRKDKKPPLIKGAGEDKSRVYCAWNRNFGETPEENTLYILRWIYDEPTSAEETEATARAMAAILKRAQLEAYEWNMAKVQFWNPTPLMEKAVAMLDPTAKIIHREMDSVACLKWNGAEKKDVEWLWNEKYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNI5</accession>
    <name>A0A5N6TNI5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742196">
        <property type="protein sequence ID" value="KAE8147671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNI5"/>
    <dbReference type="OrthoDB" id="4502188at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="163" mass="17508" checksum="00558472EEC7451A" modified="2020-04-22" version="1">MTAQAKTNLPRDSEILSDSEISVLDIGPSLNIRKPSRPTMAGNSPNKGIVSLNGAAFTPNQTCTLPDKNPQVSAQSTHYSSSIRKNEQVDLVDQTMGDDTPKKNKRSRSDTVRGALRTISSPLLSPLRSSTSSGKAERDGRPGVSRSKTSFRGQGGTLDRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNK7</accession>
    <name>A0A5N6TNK7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_142301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNK7"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="251" mass="28685" checksum="E38624A79313AB28" modified="2020-04-22" version="1">MVDIVPLSSYPSYIDLLPSIQTCNITNLPENYFLKYYLYHALTWPQLSFVAVVRPKAGYTKHTDEEGRGSATLAEQYPKVVGYVLAKMEEEPTDGMAHGHITSLSVMRTHRRLGIAERLMRMSQRAMAESHRAHYVSLHVRVSNTAALRLYRDTLGFQVESVESKYYADGEDAYAMRMDLKDMWMNWEEIERKDRLRAEKDEKDADEGDDVGDLGKKDAEEKEKEKMVKVKVGRGLGVGDLVEKNESQVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPG5</accession>
    <name>A0A5N6TPG5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="9" type="ORF">BDV25DRAFT_20367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="ML742168">
        <property type="protein sequence ID" value="KAE8148242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPG5"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Flavoprotein" evidence="8">
        <location>
            <begin position="64"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="247" mass="27181" checksum="8B7100BA001D67C0" modified="2020-04-22" version="1">MGLLGSIVILVGSLLFLAVRFPAFRKPYIFHGYFAKSPAINMSKGDNPSKSLTKEMQPPIRPTRIVVAMTGATGAILGIRLLERLREMNVETHLIISRWAIEAIKYETKYSVSDIRALATRCYPVNNAAAAVSSGSFQTDGMIIVPCSMRTLSAVRTGFADDLICRAADVTLKEKRKLVLVVRETPLSCIHLENMLALANYGAVIFPPMPAFYTMPGSVDDIVTQNVGRMLDMFGLDAGNFDRWNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPK4</accession>
    <name>A0A5N6TPK4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPK4"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000510">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="9">
        <location>
            <begin position="167"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
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        <source>
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    </evidence>
    <sequence length="700" mass="75616" checksum="72CF8BA429BD1908" modified="2020-04-22" version="1"> </sequence>
</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Baker S.E."/>
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            <begin position="47"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
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    </evidence>
    <sequence length="139" mass="15476" checksum="71C4E77E651125C6" modified="2020-04-22" version="1">MSTHPELKDLHKILFDEGLKVRRAVVGDTHVDRSLANGSSEFTRPGQELVTEWCWGHVWTRPGLERKQRSLLNLGMLIALKAWPELGVHTRGAINNGLTPTEIREAVLQATIYCGVPVGIHATKITDQTIKEMMENGAL</sequence>
</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Haridas S."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
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    </reference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
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    <dbReference type="PANTHER" id="PTHR31005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148998.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="77319" checksum="DD1BAC139365EB83" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRU4</accession>
    <name>A0A5N6TRU4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">BDV25DRAFT_168186</name>
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    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742143">
        <property type="protein sequence ID" value="KAE8148869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRU4"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="483" mass="53064" checksum="CC2EB072390681D1" modified="2020-04-22" version="1">MADTASKSSSHHVEDTGKPLSTEDIQFEGLSEDDTRVFEKRLVRKIDLHLISSLFLLFIFNILDRSNIANARLGGLQEDLGLSDTQYQTAVAIMFVGYLLGQVPSNIILTRVRPSRYIPTAIFVWGGISMCMAATKDYAGIICVRVFLGFAESPFFPGALLLMSSWYKASELAVRVAIVYCGNTIANGFGGMIAAGILSGLEGKGGLRGWQWLFIIEGAGTMVAGLLAVLLLPDFPGSGQHKWLTPQEQRFAEWRLARSANNEVDENGSVKQGLVDAATDPKVWILVLIQVCQLSSQTWTYFFPTIVKTLGFGSIVTLLITAPVYVFGFLTSLGNSLIANRTNCRAVLIAWPLCIDIVGNIMVISSQVTAVRYIGMFLMCAGSYSAFNVVQAWIASTIPRTRTKRGIVYAMVNLFGNSSNIYGSYFFPTSTSPQYRMGGIILSSFAAGGICLSLFLALYLHRLNLKARKAEEQDGEIRYKYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRU5</accession>
    <name>A0A5N6TRU5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRU5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024864021" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7830" checksum="32A84C603CE23E7F" modified="2020-04-22" version="1">MDRRRHLGLRCVALIVTGSGCRCDLVSSCRHQGSLLATNAGRSESILNSQCRSTSSQISSSPSLSISLVIVPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSA4</accession>
    <name>A0A5N6TSA4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_130770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="ML742140">
        <property type="protein sequence ID" value="KAE8148951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSA4"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="45723" checksum="E36409768FEA5EA2" modified="2020-04-22" version="1">MSGEKIYEGIFAVHKPQGVTSADVIRKLQHHFNPSKLFQPWLETERARRNRESRNQRKRRRTQRLDVKIGHGGTLDPLATGVLVTGVGKGTKQLNDFLGCTKTYETVVLFGAETDTYDRLGKIVRRAPYEHVTREVVEKALEQFRGKIMQRPPIFSALKVKGKPLYEYAREGKEPPIEIQERPVEVSDLRILEWYEPGTHDFKWPEQEAAAEEKAVAEKLLAKDDALPVVSSTEAAGSAEKAEEQEASTSTKRKTPPPADTSEASAPTVAEDENSAAKKQKVTEDGQAVPAQTEQPPADTTKATDENAESQQEEKPCPTPRSAAVKIIMTVSSGFYVRSLAHDLGKAVGSCALMSELIRTRQANFELGPEKVLEYKDLDSGEEVWGPKVQEFLEAWEKKRAAEAEAEAEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTI8</accession>
    <name>A0A5N6TTI8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="336" mass="38207" checksum="9439D7BAE3C53930" modified="2020-04-22" version="1">MYIPNSMWTWSFCIVTFVQTVITLALECYVFADFQLKLREEVSGGESASKTIPTFLALYSFGFVYELVLVYDALRLKNTIQVIGLCLCNIGLLIYGAVQVEQIKVAIGVLAVNGAIDSDVMGQIKPFLVIIPCVVAMGTLLMMIVAWKLYDEFAWSIYKHISADLRMKRRYLTYQIYIALLKFDFFFFLGFTVQFVVIVTNRNDAEFALTLAAIPVTILILLCAALFVRRESSLGMIIIILLYFAAMAYFLFKLVRMFDKNTYTTYLPAQKSLTFFAVITLVLIVMTILNACLCMKNFHKGLKPHINRKKARKEAEKTTELSSNITGQVPNRMMID</sequence>
</entry>
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Lyhne E.K."/>
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                <person name="Lubbers R.J."/>
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                <person name="Chovatia M."/>
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    </evidence>
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        <source>
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</entry>
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                <person name="Henrissat B."/>
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                <person name="Machida M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="651" mass="70237" checksum="6CFE4703707B94E7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUK9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="67" mass="7919" checksum="05617C48AE385A1B" modified="2020-04-22" version="1">MEQSRAVPNFRLPGQMSKLRWGETRNQSRKRGCYMQDMRLSSLSLSADLSTLFLSYIFFLFSFFGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV29</accession>
    <name>A0A5N6TV29_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_155313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Checkpoint protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dual specificity protein kinase TTK"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mps1_cat"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="492"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="423"/>
            <end position="486"/>
        </location>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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            <end position="57"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <position position="520"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="833" mass="92315" checksum="8BDFB25D764A9F26" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_110498</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742092">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10959" checksum="4EE6FFCA75A0F8B2" modified="2020-04-22" version="1">MINPRIDGVATQGKLLPTIIDELARDDPNGLWMEYPSSLSTFDAGFNQITYAELANSVNGVANCITSALGREDTGEPLAWLAPNSPLCSITLIAAMKAGFKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVY3</accession>
    <name>A0A5N6TVY3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_129459</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
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                <person name="Machida M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">IBT 18842</strain>
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        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
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            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
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        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PEX14"/>
    </dbReference>
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        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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    </feature>
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    </feature>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="699" mass="78310" checksum="A698C75EE9CE89C6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    </gene>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Chovatia M."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWT3"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024944397" evidence="1">
        <location>
            <begin position="19"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="131"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="435" mass="47526" checksum="CB14400F68C0EA44" modified="2020-04-22" version="1">MPFKHFALLLLTAKLALGQAISVAATQSTGWNSSFELSFEQVKLGNLTSGMATIINTITNFDRSQLANGGAHEDEFYNVQDLPEGDWPTEPGKAIKIQESTDPSPFAIPAKTAMSRIVYSTTNANGFYANGAPSVHRALFYADIVPFALAKAGYAVVAPDYAGLGVDSSWNGSRIPHQYFVRQAGAYDALNALRAAKGSFSERLSSKYVVMGHSQGGAVAWGLAEILSRGDAMFEDVSKDYLGAVIAAPPTDALSFTTAGFLAWVAKDLDHIYPTFKLSDWFTPLGVRRIELLNQIEGSQMVTFAMFSPDEELLQPDWRKTSYAKAFEGLTNPDDVTVPYNTTKTTVEDTCQAYPGDLEFVTVPQGSHFSAISAAQQMWLRWIEGRFDNQPVAKAGCIESQLDSLLSSENYQVLPNSFLQWAGEPQWSYELPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWU8</accession>
    <name>A0A5N6TWU8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_106333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWU8"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08995">
        <property type="entry name" value="GH32_EcAec43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="519" mass="57830" checksum="928D93B520EFA016" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX29</accession>
    <name>A0A5N6TX29_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_171885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX29"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF1">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE C186.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="416"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8150850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="581" mass="64611" checksum="1C0CC8BC4D6EF82B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXA3</accession>
    <name>A0A5N6TXA3_ASPAV</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_139540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="139" mass="14858" checksum="62171BA646DE1F20" modified="2020-04-22" version="1">MSSHPKNHSNNSTTYTTHTNHKTTKPNDNITEYLQTLFEAHILPHIFRLLDLAQANPLISSFLLVQFLCSCVPIALFIIGAVVAAATALMVFSCVAAFVLGPVVLGTTVLGVVVWGCAWVGGVGGRVAFEALKSYGVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXT7</accession>
    <name>A0A5N6TXT7_ASPAV</name>
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            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BDV25DRAFT_153110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Mondo S."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10003767at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8209" checksum="D1F224FC3BFBCE67" modified="2020-04-22" version="1">MRSGPAEEILSSTRTIPTLLHEISGNISVNDTGPFPLYHLNFHHGNAVVNPSFEALGVIDWEGACIVPWEMVEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXV9</accession>
    <name>A0A5N6TXV9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-ketoacyl synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_139362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF40">
        <property type="entry name" value="NORSOLORINIC ACID SYNTHASE STCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="375"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1635"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1732"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1748"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2042" mass="223238" checksum="A3BD904A00C33D13" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYE2</accession>
    <name>A0A5N6TYE2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_152752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYE2"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF2">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="260" mass="28585" checksum="D51BC24410073625" modified="2020-04-22" version="1">MSTILPRTLRSLTRPATKLLIPRPIQRQARSVQIASATAQDHHASTNSTRVEEVPPFRPQPPPSQPPQHQVEAYISRLPLVQSLRRDPIYKESRPHLSMDPSLRPAHFVAGSLAGTDKITVPPYMFTSTEKLESDKRAGRVISVFHIGNQMCGHPGFVHGGLLSVMFDEAFARCVSASFPSGLGMTANLNVDFRKPAVPDRVYVLRAETVTVEGRKAWVEGSLSSLPAAGEQGDPVMVAEAKALFIEPKFAETMVPLYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYK3</accession>
    <name>A0A5N6TYK3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_95098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYK3"/>
    <dbReference type="OrthoDB" id="5015991at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="111" mass="13360" checksum="293493A5034D367C" modified="2020-04-22" version="1">MCFYNQRRFACGDWSWTSFAHRCNYEYRTGETCGMKLVNVTENESSLCRLCEKIETKFRRRSAEMDRLNRWKRDGSQLPASIAKTQHAIMELDQEIRQLQRERDDRRKALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYY3</accession>
    <name>A0A5N6TYY3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYY3"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="136"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="212"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="42490" checksum="4A5ACF9DC809A700" modified="2020-04-22" version="1">MSFLKNFFGTSAVVEKEAKTPVRALPASWYTSQAMYELERRAIFGRKWLLTTHKHRVPYAGDWVEYNAAGYEFIIVRDHQGNVNALRKDTLTPIHKHIDCNGFVWVNMDASPVPEVAWKDDFEGVDEQPRFQHYNFEEYVFDHTWDMEGDFNWKILADNYNECYHCQVAHPDIPTIADLNSYYVKTKDGHIQHYGAPRQDQIDKGFRIATTYFWPNASFNISPNFFFMQRFTPSSPTKCVMRYEVYRHKDATDEAFNLISDMYKRIMSEDKYLCIHTQKNLNAGVFVNGQLHPEMELGPLHFQKTVREVVTEHSEKEDAVGHEIWPAHQDLPKSSISEDSIDFTYNEKDSLADTLNTNFAPAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ32</accession>
    <name>A0A5N6TZ32_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ32"/>
    <dbReference type="OrthoDB" id="4419870at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="137" mass="15096" checksum="F5DA1F7978E99AF7" modified="2020-04-22" version="1">MSNTLVPLTVIKGAGHEFIPLPQGENATTADFHSIRTKTESPAYFTSGFYKIEAGPQRPAHYTFEETKYVLSGQIDVLDEATGITHHLVPGDFAFFHVGSKVKFSTKSQGFAFYAVTRPVRAPHPNLQGREEGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZM3</accession>
    <name>A0A5N6TZM3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_138785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="339"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150908" checksum="965FD512AC786611" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZY2</accession>
    <name>A0A5N6TZY2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_128445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZY2"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
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</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
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                <person name="Chovatia M."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Makela M.R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1832" mass="208816" checksum="FC68A6DCC8BA1412" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2D0</accession>
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        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2D0"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="58774" checksum="1BD85EE1A7DF4586" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2G7</accession>
    <name>A0A5N6U2G7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2G7"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="200" mass="22299" checksum="690855E0B0011801" modified="2020-04-22" version="1">MSEKQFTVPPHLEQYTAPLAVFRAANPQYTHFVVGGLVFSNPTPTTDNPSPESKVLLLRRALTDSLPGYWEGPGGGCEETDDSIVDAVVREVREESGLHVSRVVDLVGIEEWVKLKPDQVVKAVKFHFLVEVWEAQGFIPGGEGQVVERWEDGVLLTPEEHDAFVWEGVDEVRASLEGKGKYMVLEDEGRNLVKAFELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2H0</accession>
    <name>A0A5N6U2H0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_59755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2H0"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="60877" checksum="9BA3A0954FADC32C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2V3</accession>
    <name>A0A5N6U2V3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_127596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2V3"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="493" mass="56357" checksum="E5A5331B1C47CB67" modified="2020-04-22" version="1">MNLLPTRYADNACWTCRRRRRKCDRLLPACRQCTSAQRQCLGYSTERPLRWTNSVASRGRLMGQAVPNVEIKVPLGRSLIDPGLQDLSLPMRGYIAYFEQFCCQECVVYDSGPTNAFKEFLSLIPSSRGLCHIIASISALYQAQRDVSNQLRQGQLFFTDALVEDGHGNDWLTKQRYHDFLFHKQLALQFLRRECQQASPQDSFGIIASILMFIWSELMESGSHTWVYHLEGLRQIMMRNASDYLSGSAQCLASSFSRLYEYFDTSYAIFEIIGSTLIQSKQSYEPLLMPTSALDILKRSESLTWTGCPAELLYILSLVHSASALDTHAPDVVLDLFCRLEAFSPEQWAILSPLPSHVPNRFRVSSIYQAAICIYMCQVFSFPLGGPYRTPTDANAWLDHTIALFTTMDPQDRYFRALFWPTFVIGAEAQTQTQRKVIMEALHHLWIAWAGAQNVVHAAEVLKEIWGRNSTDGVPPEPWIQFLYERGENWMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U331</accession>
    <name>A0A5N6U331_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_44911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U331"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="377" mass="42259" checksum="DE1F63BC55B81DA3" modified="2020-04-22" version="1">MDSTDRSGAVVIDNGTGTCKAGFAGDNAPWTVFPSIVGRPRRYGSTEEIKKEDFYIGKEAEARHDVLRLRYPVEFGIVTNWDDMESLWRHTYRNELRVAPEEHPVLLTELPFNPKSSREKMTQIMFETFNVPAFHAGVQPLLSLYASGRTTGVVLESGEGTTHIVPIHEGSVLLDSVKRVDMAGRDLTDYLTKLLREQGYTLPAKTEHEIVRDTKEKVCYVALDYEEEFPASMHSCTAVRCYELPDGQVIAVGSERMQVPEALFCPSMLGLDEASIQARMHNSITKCDEDLHEQLYGNIVLSGGNTLYPGMAERLQAEIARYAPPGMNIKVAAPPERKYLVWIGGSILASLSTFQNMWISKQEYDETGPAIVHRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U355</accession>
    <name>A0A5N6U355_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U355"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="38411" checksum="F03ADDDFD7A9F1EB" modified="2020-04-22" version="1">MLGLPEIDKSHRTELLMRLGRALQKQEVSATFWACLQVGDLSALERFVREVEASPRLCKVLSHSFDALPRLWRQKALGEGFSDIDTELSSNHSSGSQASDKLWTATMSPSAADIARSRDGKKCVITGTTCLNPSQIFPLSLLKPKATTDINGSLPNIWEILNLLFDYEHVLQWKSAILQSPDGMDTVPENLICLCPMIHIDWVDAYCAFKPLYLSPDRRELTLEFHWLPTETHSPRDHVSLFKSPSSSKNLQGTGNRYAITADLKLVKSGHVFVLKTHNPVTHPLPSIALLDMAWKLSQIVRLSGARDEDLGGLQKDYNTPHLYNLQAIREWAAESSSYAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3K1</accession>
    <name>A0A5N6U3K1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_127443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8153100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF532">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="792" mass="88502" checksum="92F9259387630FA8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3M4</accession>
    <name>A0A5N6U3M4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_137080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3M4"/>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
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        <location>
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            <end position="145"/>
        </location>
    </feature>
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            <end position="185"/>
        </location>
    </feature>
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            <end position="324"/>
        </location>
    </feature>
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            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="381" mass="42578" checksum="ED8F8655934A1F81" modified="2020-04-22" version="1">MAVDLAVSVPTVVGSLLSALASAFVLVIFAASPKSHFRHWLILNLTIADFLNATNNTVSGFLVVSRHHDLNPGPGCQLNGWIGQLSVQAIDFSILAIAIVALWLVQRPTIVSTLSWRAKSRWFRAHHLLLAGTTALCLGIVGPVSGNWCWIESQYLGLRYALGHGWRIAIVFITAVTYIVVFVVVKRRYAHLSLFPNGDTSSGRDKSRSTEGDPVDLSSIRLDTTITVQSSEVFNTQANTGGVRDSPSRDYLSSQFPISAVKSLPSKDNTTSNERRLRYADTLGTRGDPTERRDKTIRYVEVRRVMLLNGYPAFYVLLWIPGLLNRLLESLGHQMRWLQILQASTQFIGLANAFTYSYNEGFRRQIRSLITRQRQSHHEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Y4</accession>
    <name>A0A5N6U3Y4_ASPAV</name>
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        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_169182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Y4"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="57"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8153298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="505" mass="54801" checksum="378C604CA11C45DE" modified="2020-04-22" version="1">MVSACVKVQEIEIIPPLENIPEQRLEDKASENVELSSSTATASNVHSIFTKHQKRYIIFIASWGALFSSMSIQIYYPSLNSLVHDLDVSNGLINLTVMSYMIFQGLSPMFIGDFADKTGRRPAYLLCFTIYIVANIGLALQTNYAALFILRCVQSTGISSTVALASGVVSDIATPEERGSYLGISMVGLLMGPMIGPIIGGVLAQYLGWRAIFWFLVIFAGTFTVQLLLFVPETARKIVGNGSIPPPVWNRPLINLHRTSESQANTTQPNRQKLTFPNPLRTLSIAFHKETSAVLFVNGMLFIAIFDVSAAIPSIYKDLYDLNSLQIGLCYIPFGVGAAVSSMTTGKLLDWNYRRMANKLNISTEGKRVRDIEGFPIEKARLQLVFPLVIVGGLSIFAFGWLLHFRTHIAAPTTILFLIGGCLTGASGSINTLIVDLYPDNAAAATASNNLVRCLLGAGATALIDPMLNAMGRGWCFTLIAFVVLSSGGLASAIIAFGPKWRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4L4</accession>
    <name>A0A5N6U4L4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4L4"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="307" mass="34522" checksum="009574816D871F8F" modified="2020-04-22" version="1">MGSIRVGDTVPPPGAWDSHVHIVDEDRFPLHPLHPYRPKKAPLSSLQAFHRRVGIDHACLIAFSVYHTDHSSILDALSQLKGKGRAVGCIDPKTITDDELQQLHRAGVRGIRLNMRTRGDPLNKAAVLEAADRVRYLGWAIQVYIALEQMVEFAPLVPQLGLPVVIDHIGAPDEARGPGRLQPGYAEFISLLKSGQVWTKLSGTYRFPNLPDLDEYVTEILRIAPDRVVWASDWPHSGGVEANPGGDRQKVQDYRKVDDVAWIVRCKQWCRDVEGDFGERLARKIWVDNPIILWQWNDDEYVGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4M2</accession>
    <name>A0A5N6U4M2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_21781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4M2"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="669" mass="75913" checksum="D273B7D746DED8CF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4N4</accession>
    <name>A0A5N6U4N4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4N4"/>
    <dbReference type="OrthoDB" id="4389629at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="167" mass="19640" checksum="F3B4433394C8C2D3" modified="2020-04-22" version="1">MDGRPLVFDLKGSTITIPDIPGRPPSTRILHIKRVWRDIFERELGLIHVLCLVENILTRERHIAKIRYELNPKHFKFDNLHAQRDLAEYRFKCEVDAARLLGDNEYGPRYMTHWKQIQSINMPFPGGLIYFLIMGTVPGDIIPENLHDKLTDAQRVDIRRQLTRMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5G8</accession>
    <name>A0A5N6U5G8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calcium-dependent phosphotriesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_148836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5G8"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF30">
        <property type="entry name" value="SERUM PARAOXONASE_ARYLESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43078" checksum="6CD023F07BF88C85" modified="2020-04-22" version="1">MMNPMLKSILGFILLSLASSYLVGRAVIVFLMFKNAPARLEEFRVNADFEVKFADQFRNCEDALMVEEDGVAILSCDAGRDRWNTVMGTFPEDPSQVPSGELIIYHYTSQKESINRVTFLDYPAANNFHPLGVEYHRPSNTLFVCNHHPNGSRLDVFSMDLSKSEATATYRSTIADPVLKGPNSVVAISDHELYVSNDHYFLKRYNPWLSTIETYAGIPGGAVAYVNVKSGTVRPVAHVPFANGVVQLNETVLAVASTSTARVYLYQIQPDRSLRRVDSVKLPFLPDNLSIDKRGTLLIAGHPHPPSLEKVAKSRPRCQADAADCPNVHAPSWVAEWKPDGSYRNIFVSKSDFITSSTAIRDADRKLGIVTGLYEKGILVWREENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5K7</accession>
    <name>A0A5N6U5K7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_148708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5K7"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55736" checksum="14DD50DCB1C16B18" modified="2020-04-22" version="1">MAADAASAPVTEHKVKPAKPSEETFKADLAQAEKEHAAVQEKLNQVKAKIETAKPNNKDSPAAKRQQELRAELSSIRQKQQGFKASRSSTQEKINALDSTLKSRIAEQNNSRTKMSFKSVEDIDREIARLEKQVDSGTMRLVDEKKALSDISNMRKQRKNFAGLDEAQKVINDLKTQIATLKKTLDNPEAKALSDKYAEIQKELDGIKAEQDSAFKNLNALRDERTKLHGEQQTKWAAIREVKDTYYKARKAYKEYEDEAWRVRREKQKAQRDAFEREKKKKVADKKLEEASRLAFTDEILTAQGLIRHFNPAYDFAALGLDDKKDETAQFRAEVGRTIDDSGMKGMKVLKKDEDDYFVGTGGKKGKKGKKSNANGAPAPAEKFNLNVGIIEDFAKVKIDPPMNQSDVPAAIEKLAAKITEWKKDQASKTEENIKKAQEEISRLEEEAAEVDGRAMDAAKKPALANSGVNGKPSADAELKQEKDAAADVSEELQKASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5M3</accession>
    <name>A0A5N6U5M3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_15257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5M3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="108" mass="11890" checksum="C53C02D4A6731FBD" modified="2020-04-22" version="1">MVLAQGGSIWPGTIESGEMAGQSRGIGPPVGLILQAISGPRTTRFAWSACRSSTPSGTIISAWLGKSSRQYVIIFFFFNLFYLFFLAPELKGRLTDFICLVFPCQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U666</accession>
    <name>A0A5N6U666_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U666"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="453" mass="50819" checksum="1A872032FFA2ACDF" modified="2020-04-22" version="1">MASGIPVHLPWPYHHGRTHRTGGWLTEDAKSVVRFVRKISSASKEAKLPLHPLIQDFKALVESTPSLRMYASAMLTEVPDKPPYINDPTGTKGVRDFTHLLHIFNYTMQKVAPQWNVDEYNIGLIGFPFNAVLDWPMATPSGYAFFLNEDVNVHMKRILEDWRIHFLSTSASAAVLTEEKDGWLSAEARRVIEEDTNLDPENWYTFEQFFGHGPADGEHWGFKSWDDFFTRQFANYDLFRPVHAPDDDTWVVSACESKPFALQSNVKDYDTFWLKGQPYSVMEMLNGEPEASDFVDGTIYQAFLSATSYHRWHSPVNGTVTKVRVVDGTMFSEPTITGFMNPEGPDPAAPDRAQGYITHVATRALIFIQAPEPIGLMCVVEVGMADVSTCEVTVKENQTVTKGQEIGMFHHGGSTHCLLFRKGVNLTWVTNAFPGVSDKNIPLRGALAQVTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6B1</accession>
    <name>A0A5N6U6B1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6B1"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="209" mass="23885" checksum="273CFB496D73115C" modified="2020-04-22" version="1">MPALNCTHCAQCTLAIAEVTRDDVPKLSQVWYRAFGTPPNLVLFPDTPCVRTWWNETNLNDLCHRPYQRFLKVVSSTDPSSVLGYAKWDLEPDRCGERFPPWHAESDGEHCSEFFDGIEQQRKNIMAGRKHYYLDMLAVNPDYGRRGAGSKLVEWGCDLADQDGVPIYLASSDAGIRLYQKFGFEILKDRKDTPNGVHPMVREPKNFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U735</accession>
    <name>A0A5N6U735_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_109419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U735"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </evidence>
    <sequence length="553" mass="62106" checksum="519E714DD5287ECB" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        </source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="236" mass="26354" checksum="A310EFF6E9177BDD" modified="2020-04-22" version="1">MSAPKITLYTNHRCPWAHRAHIALKESGLDYEEVIIDLTKPREPWYLEVNPRGLVPSLRYGEDIITESAIVAQFLADAHPSHLLPASNSKDGALQRARIAFFVDTFFSKVQPHSMASQRASTDAERKAASEALVQAIQDDLETLLPDELQGPFFGGSDRLTLAEVLTGSFLLRILSWHTPDTGLFSADLPERLQTVPRFLRWAKATVEQESVNYIWDSKASADAMKAKLAKLAQQK</sequence>
</entry>
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    <name>A0A5N6U910_ASPAV</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_37650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845025" evidence="1">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="217" mass="23611" checksum="6FC1269F70229754" modified="2020-04-22" version="1">MVFQTLITGLVAFTSSVSAMALQPRAGSITPPEGCPLPTWTVSNFQWYNGSKSLDCIHNEVDKNTKGCLCGRAWCDPTTCNSTLVNVCYTGMPNYEPWGYGPPQTLNIDFEDGLHCHDEYIGYRIHDIGYGESNCGYADRSLGRIVSFYGTSNEATSTGHMDYVLGAGHALKCANGSSISYSGSTDFPVTCTHDSFFNATCTAAPFEIPVLSYEWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U929</accession>
    <name>A0A5N6U929_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_126066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U929"/>
    <dbReference type="OrthoDB" id="5427059at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="417" mass="49006" checksum="A13365727CE76EE1" modified="2020-04-22" version="1">MENLPPELRIQIFFSCHDLVSIRSIVHASPIYHQTYQLIKHRLLLHTLHKTYDGLVDMTDAITAVRSYGLYAYEPSHKETILALLDRRRRSKEICRPIVLTTDEIIKLFKLHGIANFFLDEYAKSAPCPKWIESAKWVKDFLPLYLSRTEKVRFLRGFYLLQIYANIFGPVEFPAYESHSCLDNDWIDHTFTRVEAWRVLFGTMAPWEVAEFGCVWQYIYDKIKSPYIEIAEKFREYKSPGIGFPKEAGLPEGCIQLDGDELYMNADEILRSLVATGPVFCSRFLRLESSLHRRDLILANGRCFVWCFPFTFPATPQGQLPLLYPADRFDFGSDWNGLHKLVDSLQPWEGPNFAFRKYWLVKSHEGEAVFQSLNRARLGILLWRWGYAIWDAERLQRWSMPEDRHSAFNLFRHLFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9R1</accession>
    <name>A0A5N6U9R1_ASPAV</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8155354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1203" mass="132335" checksum="26E853B63A4A5EF8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_167683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="63" mass="7500" checksum="D47F44E4B3E00B40" modified="2020-04-22" version="1">MLYFPSLSFPLIPFQWIFSIESFPFFLFFLFSLLLSLIISVTSRFPLRSLVCNWGLILIIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TDJ9_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BDV25DRAFT_167028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="41200at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox_assoc"/>
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        <property type="entry name" value="PX_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013937">
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    </dbReference>
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        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
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        <location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="502"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="998" mass="110071" checksum="F96F40AE975434F6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDN1</accession>
    <name>A0A5N6TDN1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_166765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742509">
        <property type="protein sequence ID" value="KAE8144475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDN1"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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            <dbReference type="EMBL" id="KAE8144525.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="72383" checksum="A23DAB3285976FA6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">IBT 18842</strain>
        </source>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="6">Belongs to the MEF2 family.</text>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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            <end position="514"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="613" mass="66218" checksum="08EE2D0292FE66F8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE93</accession>
    <name>A0A5N6TE93_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_88260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742455">
        <property type="protein sequence ID" value="KAE8144685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE93"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024804575" description="Fungal specific transcription factor" evidence="2">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18101" checksum="E3E7EFC3E28200EA" modified="2020-04-22" version="1">MQSTLKGAILLNLLSNPLLSIPTRAISVSTSILRTPRLNNHITYPQCSSHLFQPKLYATMSNTETDHSQQPTETMEKKSESYLALPDANSADQSQKLDVSGDGSTVKLDHLGPLVVNQDGTLSRISNWAQMTEIEKRNTLRVLGKRNQLRMDALKAAGAGQNEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEU6</accession>
    <name>A0A5N6TEU6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_145176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="ML742419">
        <property type="protein sequence ID" value="KAE8144888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEU6"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="235" mass="25850" checksum="705A1C4BDFCE3A1D" modified="2020-04-22" version="1">MSRKETIETQAKALHEHIFSKPEDTYAGRPWELVKAIDDFANANQMMTFKGPKIEVSKEEIKKIQPPPKTFIEFGGYVGSSAIAWGAILREVNGTDNFNVYTFELSPFNASIARDLIRLAGLGGVVHVVEGPASASLEGLFEEGKLKKGGVDVAFIDHWEEFYLPDLQMCEQLGLFREGSKVLADNTDFPGAPAYLEYVRAGVGANGDIQYQTESISAPGKFRDTIVEVSTAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEX6</accession>
    <name>A0A5N6TEX6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF159 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_81092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742413">
        <property type="protein sequence ID" value="KAE8144925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEX6"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43785" checksum="D1B1A1377AF7003A" modified="2020-04-22" version="1">MAYIQQRLREQGMTVDEAPSDDEVRETYNFAPGNQGAVYRADIYPNITPSAHVQGDTTESHTGESEVSESAVHKPMYKLQSMTWGLVPFWTKRSPDYGSLMRTINCRDDSLVEDRGMWTSMKRRKRCVVVCQGFYEWLKKGPGGKEKVPHFVRRKDGDLMLFAGLWDCVSYEGSEDQLYTYTIITTSSNPYLKFLHDRMPVILEPDSEAMKTWLDPGRTTWSKELQSVLKPYEGELECYPVPKEVGKVGNNSPDFIVPVSSKENKNNIANFFANAKKPKTEPGVQAEVEDHRPTKDSEWSEDNAPKPVAGVKREHTPEGPEHVADETLKKPKAEPVTPLPGKPTEAAKQQPLGSGRKTRSATHNQKTAKKTDEKPTDGSQRITKFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFD3</accession>
    <name>A0A5N6TFD3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_78792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
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    </evidence>
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</entry>
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                <person name="Nybo J.L."/>
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                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
        </source>
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</entry>
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                <person name="Makela M.R."/>
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                <person name="Chovatia M."/>
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                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGL6</accession>
    <name>A0A5N6TGL6_ASPAV</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">BDV25DRAFT_69417</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742337">
        <property type="protein sequence ID" value="KAE8145528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGL6"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="491" mass="55330" checksum="1CD64F18B843C448" modified="2020-04-22" version="1">MSVFRPGRLRTLLCASAALILICTFYLYWTPPPASTVPSTAFEVPLTERQSAFWKVLKVILDTHAPNCPSPTLRLPVDAKHFNATASDPRPDYILLGNEELQAMKDAHASYINDVKNTRKLRPVHAPGTRGLISTAGGSYLPVFLSSLRMLRRTGSTLPVEVYMKDATEYEKSICTNVLPDLGAKCLILSDIVGKDTIQHYQLKVFAVLFSSFEEIIWMDADCFPLDKPEILLNHEPFTSTGMVTWPDFWASSISPLYFEISQQEIPPMTERQSSETGVFLISKKTHYLTLLLAAYYNYYGPSHYFRLLSQGAAGEGDKETFIQAATAVGQPFYAVSERVQALGRHKPDGFSGSAMAQSDPIGDYALTSQGKWRVQDPSVDRPPRVFFVHANYPKFNPAEYIFGDKWETAPTLRPDGTEGRAWTAPEDVLRRFGLDIEKAYWEEIKTLSCDPEIKFKTWKAKTEVCKKVESYWDTVFAEPHEDDPKFVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THJ1</accession>
    <name>A0A5N6THJ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_66675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742329">
        <property type="protein sequence ID" value="KAE8145609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THJ1"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="19086" checksum="410C27E2FA515860" modified="2020-04-22" version="1">MDVSSNRLFRFSKPEWLNNNTVRNAGVYTSGALFSLGFFFLIDAAAFSHSSRNGSNVHVKFVDWIPGICSALGMLVINSIEKSRLHADSWSYSGNGVAWKARFVLFLGFALLAGGLAGSVTVMVLKYLIKQYPLQTLYFGIANVVANGLVMLSTIVLWISQNIEDDYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THN5</accession>
    <name>A0A5N6THN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742314">
        <property type="protein sequence ID" value="KAE8145770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THN5"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="110" mass="12608" checksum="249307E05C633330" modified="2020-04-22" version="1">MFPTVARLSQAVCVTLFTRAGCGLCDTAKHAVTQLHKRRPFDYSELDIMLPSNKLWKDVYEFDVPVLHVQSVKAQSGKEEVDLSDPKKLFHRWTEQEVETLVDEVEKTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THV7</accession>
    <name>A0A5N6THV7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hsp90 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_164011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742318">
        <property type="protein sequence ID" value="KAE8145729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THV7"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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    </dbReference>
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        <property type="entry name" value="Heat shock protein 90 alpha"/>
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        <property type="entry name" value="Heat shock protein 90 alpha"/>
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    </dbReference>
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        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
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        <property type="entry name" value="HSP90_C"/>
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    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="698" mass="79611" checksum="F91D2B9197AFE2D0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY8</accession>
    <name>A0A5N6THY8_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_144182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8145956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="210" mass="23397" checksum="7DD2A60224A30183" modified="2020-04-22" version="1">MSLWKDSFLNLRHAVPRTVSGDRICRTQSKRFLTYSSQNSRLIAQNSIPLQTRKSTSSICQQRSWNGFKTGRRDFSATAGVRHGHITPPKPGEEINVSFLDKDGEKYDFQVSEGDNLLDIAQANDLEMEGACGGSCACSTCHVIVEDPDAFDKMEEPSDDENDMLDLAFGLTETSRLGCQVIMNKDLDGLVVRLPSMTRNLQASDFEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TID1</accession>
    <name>A0A5N6TID1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_163074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742284">
        <property type="protein sequence ID" value="KAE8146138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TID1"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="3">
        <location>
            <begin position="160"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="438" mass="46401" checksum="FB56D1FF785A5920" modified="2020-04-22" version="1">MAPNSNPQAQSEFPSEKPQRNHTSSPSIASKIDTASANGVESIDSPYFKELQRSLRNTLKKLNATVKVDAIIAENPGKSLEDLVTEKKINLDQKAQALKKPALQASIAQIEEQISHYKEFAAQYERRLVTQKAELEKAHKDELDAVREQVAAETNKAGQADLKQRLLNLSKFLCAAATMRRSGDETSSLTRAFEGVLYQVYGGSHEAVSAMLKLIDGVDDKVISVEGEALDITYGKVKESSEEHAPTAEEAPTDSAPASDPTLANAGYTELQDASCSNEASAANGSAGTAAQQEQVAPPAQTLVSDAANPVAEASWNPNPGDSPPSTNTEGWVEVPRDAAEPDDGLQATPPTGDATVEDASGKTAENVTEPKAQGGDGFESVVHHQRQPSFRGRGRGGRGRDGFRGRGRGDFRGRGRGRGGRGRGGPNGNPATPAGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIR1</accession>
    <name>A0A5N6TIR1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_133079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742275">
        <property type="protein sequence ID" value="KAE8146258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIR1"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="631" mass="69287" checksum="8F86B349A2E3907E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ33</accession>
    <name>A0A5N6TJ33_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_170043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742286">
        <property type="protein sequence ID" value="KAE8146099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ33"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="477" mass="51693" checksum="E1DEC59447A43DF6" modified="2020-04-22" version="1">MTSLIPGSKRPPWLLRYRSSTAFIVATVWTSSFTDYFLYAMIVPVMPTALVERAGVPYQDREYWVSVLLMCEAAVAFICCPLFGYIIDVSPTRQFPFLLGLILLGASMGLLSLAHTVGLFIVARLLQGGATAMVAVAGLALLTDSVAFDNLGQTIGYLGSAIALGFLLGPLLGGLVYNAAGYQAVFGMAFALIALDMVMRILVIEKKVARKYHDDPDSTNPESHPREYDYNTFNNTPQEPPKPQKPALLLIARQPRVLISSWALLVQGILYSAFDATLPVFVESHFGWGPFGAGLTFLPSSITALFEPYFGSLADKHGPRKIALIGYTLLTPPLFLLRYVTTHTTPQVTLLITLLTLIGALNNLTLPALFVETQRVLDDMERERPGIFGPKGAVAQAFGIQTMAQFLGLFLGPLWGGFLEWRFGWGVMSGSLAVLVAVTAVPVFWLGGPDIPDDEGGCGFSSESVDGSGVGERERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJC6</accession>
    <name>A0A5N6TJC6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_162449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742262">
        <property type="protein sequence ID" value="KAE8146442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJC6"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="336" mass="37127" checksum="2E10DC2605808EAE" modified="2020-04-22" version="1">MAFFLRRPFAVPTALRQVPKTANTARFIHNTPFKAPLPKPAGPVTSSIFAKSRQTFQNAFRRTYMQQSYAPQSGNLTQRLLYGAAIVGGTILATNLIFNRETREDGGMPPYERSYLNDTFLHTGLGIGIIGIAARALHMNGWSYRLMAMNPWLVAGLGLVGSIGTMYGTFYTSPDNYLAKYGLWTAFNVTQAALLSPLMFMHPALLARAGLYTVGMMGSIAFVGATAKQDKYLYLGAPLLAGVTIVALSGLAPLVLPVTATRTLMWSEKIWLYGGLAVFGGFTLYDVQKVLHHARLAERGYVRRDVVNESISLELDFINIFVRMVQILAMQRQNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJR9</accession>
    <name>A0A5N6TJR9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJR9"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF143">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="53361" checksum="ECE26428C7EB1A31" modified="2020-04-22" version="1">MSEKQNNPQNERDLEAASSEKAPVDPDLVTWDGPKDPENPKNWPSMVRWRTTVAISIFTFISPVSSSMVAPALSQLGTDLHMHSEIEMELALSIFILAYAIGPLFFGPASELYGRVRLLQVSNLWYLIWNLGCGFARNPAEFFIFRFLAGIGGSAPIALGGGAISDIWNAEERGKAMAIYTLAPILGPVVGPIAGGFIAEYSTWRWVFWSSSAAAVSIQIIGFLWLRESHPGTLLKRKRDRLVRETGNSRLHTGGKTPGSKFGPALVRPVRLFTTQPIITIVAVYMGYLFGTTYLLLATFPVVWTELYGENLGIAGLNYISIAIGSFSGIVLNAIFIDRIYRHLKDRNNGSGCPEFRTPTIFIGSLMITVGLFWYGWSVQGHIHWIMPNVGVAIFVAGTMGCMQGMQTYIVDSYQTYAASAMAACALLRSLAGFGFPLFAPYLYQALGYGWGTSILAFISIGVGLPAPFVFWFYGGQLRAMSKYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJV9</accession>
    <name>A0A5N6TJV9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_143488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742249">
        <property type="protein sequence ID" value="KAE8146658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJV9"/>
    <dbReference type="OrthoDB" id="5406275at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="493"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="815" mass="89012" checksum="B293571039A3E997" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK16</accession>
    <name>A0A5N6TK16_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_162035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vesicle docking"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <end position="40"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146682.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="395" mass="44942" checksum="279B02A32C73885C" modified="2020-04-22" version="1">MWRDRTNLYISYRQSFAHHPAKKPRYIGSSNGFSDTPSQPEESRRLISETGGFEDDGDAIIEMDILPPRWVDVQEEVTELLADIAQKSAHLDKLHQKHLLPGFGDEEIRKQEEAIIEQFTQDITRAFHECQKAVQKIETMVRDAKEQGGVSSGDETMAKNIQISLASRVQEASARFRKKQSTYLKKLRGLEGAANSFERSPTPVQNPYTDPSLMESDADKSFSQSTIMQTSQRLTGENDAAIMQREREINDIAKGIIELSDIFRELQSMVIDQGTMLDRIDYNVERMNTEVKAADKELKVATNYQRRTTKRKVLLLLVIIVAGLFILLLVKPKRNSSPEPAPAPAPAPDPPQPNTEPNQQADDVFPRTIETIYRRKRRPLSAQEARKWVDPDINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK26</accession>
    <name>A0A5N6TK26_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_161954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742246">
        <property type="protein sequence ID" value="KAE8146716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5521299at2759"/>
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    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="682" mass="79310" checksum="1206056383DF70C0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKB8</accession>
    <name>A0A5N6TKB8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_161754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKB8"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF3">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="370"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8146787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="597" mass="64486" checksum="6A66FF81FC30E3F3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKD3</accession>
    <name>A0A5N6TKD3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_44674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ML742241">
        <property type="protein sequence ID" value="KAE8146814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKD3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="505" mass="54847" checksum="30820E0E7FC54751" modified="2020-04-22" version="1">MAGLDLFIDLTAPNGRQWKQPTGLFINNEFVKSSSGQTIASIDPATTREIASVYAASAEDVDTAVQAAKTALKDPSWKQLPATDRGILMGRLAELLEKNRELFATIDAWDNGKPYHVAYEEDLTEAITTFRYYSGWADKTFGQTISTTPQKLAYTIRQPIGVVGQIIPWNYPLSMAAWKLGPALACGNTVVIKAAEQTPLSILVLGNMIKEAGFPEGVVNIINGYGREAGAALVQHPLVDKVAFTGSTATAREIMKMAAVSLKNITLETGGKSPLLVFNDSDLEQAVKWSHMGIMSNKGEICTATSRILVQKDIYDTFVENFKSTIQATSKIGNQWDESTYQGPQVTRAQYDRVLSYIQLGISEGATVVSGGGPYPPNSNGESGYFVSPTVFTNVTDSMRIYREEIFGPVVVIVPFETEEEAIERANDTTYGLGAAVFTKDLERAHRVAAEIESGMVWINSSQDCDPRVPFGGVKQSGIGRELGEAGLEAYTQVKAVHVNMGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL81</accession>
    <name>A0A5N6TL81_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_161125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742226">
        <property type="protein sequence ID" value="KAE8147095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL81"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="39375" checksum="5F589C5A2686A367" modified="2020-04-22" version="1">MATTTTSSTSPTPATVFPRSHVGFDSITSQIERKLLKRGFQFNVMCVGQTGLGKSTLINTIFASHLIDSKGRLTPDEPVRSTTEIQAVSHIIEENGVRLRLNIVDTPGYGDQVNNDRCWDPIVKYIKDQHSAYLRKELTAQRDRYIQDTRIHCCLFFIQPSGHALKPIDIVVLKKLSDVVNVVPVIAKADSLTLEERQAFKERIKKEFAFHNLKMYPYDNDELDDEERAVNVQIKDIIPFAVVGSERTIVVNGQQVRGRQNRWGVINVEDENHCEFVYLRNFLTRTHLQDLIETTSQIHYETFRAKQLLALKESSTAGGHSGGSRPISPSAERELSRNSQRMTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLE4</accession>
    <name>A0A5N6TLE4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLE4"/>
    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="470" mass="50664" checksum="F5DB0897218926B8" modified="2020-04-22" version="1">MRLDAVLPFLGVVFANPVIPRQDDTVTATPTTLTGPSDSCVSTSTSSQWLSICDTSIFWPTSTDYFYGPTTGPEASAVSCNAEWVEYDGRATGLASLGVTSTSTYYETYTTSAGACNTYIWGEGWNDPHTGPVTTLCDDIPRALGPRESSTSYWPGTGPCSSYEMTETLTTVVYRSPSPTPSCELNRQDCIPIWKTYSELRSAWSATATTTTPGDTNSPIRPRSCPSTSRNYTVADPCTNCHYLPGTATLFYWPVTTTSGDLCRQDGSTVPATPTGDGPNTAVVDGKTLVSPSIYVSFTSIYARSNQRAHPGGSCGGEYEDVIISVDPTAVSSYRGHRNAKYPYIGTAYPFEYDEFQPHEVGNYTMPLIPWDKYNAGSQCPFRPAEGGACTMVRDDYLPWMGIPDGVMTQIDPRWTECHRSWYIPPVSMVPLVDGLPSWPTAAASAGSPPVTTAVPESGLAAPTPEATGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLN1</accession>
    <name>A0A5N6TLN1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_160707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="ML742216">
        <property type="protein sequence ID" value="KAE8147266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLN1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="506" mass="54327" checksum="BD018AB8389B89DA" modified="2020-04-22" version="1">MSLLREAERCIANQKSHVSLNAFITALQPSGQWREQARDAELRAQQAQPKSKVDGRLIAIKDNICTRNFPTTCASGILDKFSSPFNATVVEQLERAGAIVAGKTNLDEFGMGSHSINSRFGPVQGVRHGRDAEPFSAGGSSGGSAVAVATDQCYVALGTDTGGSVRLPAAYTGTVGFKPSYGLISRWGVVAYANSLDTVGILGRNTADVRDVFNIVNQHDRRDPTNLSPSSRSRIFSHLQTPSLASRMTKTPLRIGVPIEYNIAELEPSVLHAWLRSLVYLEQQGHSIHPVSLPTTKLALSAYYVLAPAEASSNLAKYDGVRYGTPFEDVDGHKQSQGYLYANTRGHGLGSEVRKRIVLGAFSLSADAMDNYFIQAQRVRRLVQRDFNSIFKAEQPLASHWPDVEPASVKSGVDVIICPTAPSPPPRTSNLMHPDTASSPLDAYVSDVFTVPASLAGLPAVSVPVTGSTNDLDAENGGLTGIQVVGQYGDDELVLKVGELLEGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLZ1</accession>
    <name>A0A5N6TLZ1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENP-Q, a CENPA-CAD centromere complex subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_160992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742223">
        <property type="protein sequence ID" value="KAE8147139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLZ1"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="254" mass="29344" checksum="652B28771015FD02" modified="2020-04-22" version="1">MPPKRKHSNEEHDQDNARTKRYAYLKPHVRRVSERTIKTKWSTLPEATQDKVRDMFRALERPVIVRQQNERKRIEAQAAVQTVVKNLGKRLPRMPFPPVTKDSVFEYEAALKEHRSLEANLATMTDSIDLLRAEIEKEELLLAKEKKQLQEIEKNARRVEAEKKRQLKNEHPVLRQLNVAEKQHQERTPVLVASDKSLHTTFGELETDPEVGRLVRQLNGHLRSMQNNTAPLTGLSDAITRSQMALALTSVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM17</accession>
    <name>A0A5N6TM17_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742209">
        <property type="protein sequence ID" value="KAE8147392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM17"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66966" checksum="0E40F93A5E2CE706" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMM3</accession>
    <name>A0A5N6TMM3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_159998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="ML742199">
        <property type="protein sequence ID" value="KAE8147612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMM3"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="122"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="601" mass="66878" checksum="49D32C1ABF1B9A20" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN66</accession>
    <name>A0A5N6TN66_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742193">
        <property type="protein sequence ID" value="KAE8147727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN66"/>
    <dbReference type="OrthoDB" id="5357531at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="180" mass="19670" checksum="89CFE0294D21E94C" modified="2020-04-22" version="1">MYTARAVARPKLTVSISAAQNASRPSLSLKSPGPLPRTPISPSAASPSSARFSSLQVPNYHYSNSCSSKSILKKQTNTGATAVNKRIQFKGTPTVHCVTPIENPEEYYGTYTKLSREERRWTKDLREEHPEYRGFVFHRDMLLASVPAPDSGLAISLQHICRTACGGPSALSVGRPNLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP33</accession>
    <name>A0A5N6TP33_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bacteriocin-protection, YdeI or OmpD-associated-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742186">
        <property type="protein sequence ID" value="KAE8147891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP33"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24414" checksum="95AB694689DFB3A6" modified="2020-04-22" version="1">MLSNPEPSDLPIHTFESAQDFERFLEREHSIAPGIYLKLAKKSSGRVSVSREEAVETALCFGWIDGRALAYDQHSWLVRYTPRRAKSVWSKKNVATVEALRTAGRMRPAGIAAVDAAQADGRWARAYDGPAAITVPEDLATALAQQPEAEAFFESLTRSDRYTVLASLQWVTPERRPTRLATVVQMLAEKRTSSRQGTTVDKRKAGADKGARRVRSRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP69</accession>
    <name>A0A5N6TP69_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742176">
        <property type="protein sequence ID" value="KAE8148090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP69"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148090.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="55259" checksum="EB6E2D21E56097E0" modified="2020-04-22" version="1">MSTTTKIDEPDHLSPDRPPSYDDATASTYRTNADVLNRAIQNIGMGRYQWQLFGVIGFGWASDNLWPIVTSLILVPVSYEFNVSEPPLLTLAQNIGLLVGALFWGFSCDLFGRRWAFNLTIGITAVFGLAAAGSPSFAAVGVFAALWSVGVGGNLPVDSAIFLEFLPGSHQYLLTVLSVNWALAQLLANLIAWPLLGNLTCASAETCTKSNNMGWRYFLITMGGLALLMCIVRILFFTLYESPKFLMGKGRNDEAVTVVHEVARRNGKMSDLSTDSLEELLSADEDQTPRQGLKASDHMRMLLEPLSLPHVKALFNTPRRAWSTGLMILIWTLIGLGFPLYNAFLPYLQQTRGVQFGDGSTYITYRNSLIIAAVGVPGSLVGGAMVELPRLGRKGTLTLASISTGTFLLASTSASTSAALLGWNCSYSFTSSLLYAVLYSYTPEIFETKDRGTGNALVGAANRIGGILAPIIAIFATVQTSSPVYVSGVLFLVAGFLVLFIPYETRGTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPF6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDV25DRAFT_158766</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="22"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="100" mass="11326" checksum="9A2FFE294EC59B2B" modified="2020-04-22" version="1" fragment="single">FKWHVFSFFIFLDLRPHLNHAAGETLNQSVTGNSWGNIWSDVSVSDRISDTPCVYVCLVSSSWHRQPKAILCNKQGYPWTLVHIAMGHTCPTKTTPLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ86</accession>
    <name>A0A5N6TQ86_ASPAV</name>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_17077</name>
    </gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">IBT 18842</strain>
        </source>
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        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoethanolamine N-methyltransferase, putative (AFU_orthologue AFUA_6G04290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="547"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        </location>
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            <end position="742"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="814"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <end position="977"/>
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        <location>
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            <end position="1028"/>
        </location>
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        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118040" checksum="A8137144C0EA5967" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQI5</accession>
    <name>A0A5N6TQI5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative C2H2 finger and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_158007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742154">
        <property type="protein sequence ID" value="KAE8148595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQI5"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000290">
        <property type="entry name" value="C2H2 finger and ankyrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="226"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8148595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="640" mass="71543" checksum="1A13ADF422A49F75" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR27</accession>
    <name>A0A5N6TR27_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear envelope pore membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_141408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR27"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="451"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="557"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="759"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="872"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8148813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="140175" checksum="FB51BF12ABEFB972" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRB0</accession>
    <name>A0A5N6TRB0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_141423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRB0"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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                <person name="Nybo J.L."/>
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</entry>
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                <person name="Isbrandt T."/>
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                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="371"/>
        </location>
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        <location>
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            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
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            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60917" checksum="D95BBB4316C344E7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSE0</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="ORF">BDV25DRAFT_156692</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="445"/>
        </location>
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            <begin position="586"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF12927"/>
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            <dbReference type="EMBL" id="KAE8149275.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <text evidence="1 2">Belongs to the GST superfamily.</text>
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        <property type="protein sequence ID" value="KAE8149031.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF-GSTs"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="84"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="229" mass="25603" checksum="D2ED3DE58045AC0F" modified="2020-04-22" version="1">MAFGTIYTFPGDQPRTIAIKAVAKANNLDLKIVEEPKTPAHFAVSKLGKVPAFVGEDGFMLFECMAIAIYITSQNEETTLLGKTKQDYANILKWMSFFNSEIIIPLVEKYLPLVGIRPYNKETVDMFANMAQAAVDVVEEHLDGKTFLVGGEISLADIFCAGIISLGFMFFYGKEWRQANPNVSRWFEHIINQPIYSAVTEKIEFLDEPKLTNVPPKQGEAEPAPETLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSL0</accession>
    <name>A0A5N6TSL0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_130453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSL0"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF74">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="407" mass="45609" checksum="275E006958C29EA7" modified="2020-04-22" version="1">MLADEKAGRRLVRKIDWRLMPVMCFTYGLQYYDKAILSQAAIFGLREDLMIEDGLKYSWVSLIFYFGYLVGTYPISLLAQRYRIRVVCSVICVIWAMVILCTPACTSYAGLLVNRFFLGVVEAGVSPICMLVVGLWYTHSEQVLRSSLWYSCSGGSLLISPLINYGLGSITGGSLSPWQYMYLIAGAATFAWGIALWWLFPDSLEKTPGFSTEERQLLLERVKLNNSGLENKDFKLGQFKEAMSDYQFWAIMFANARLYIIAGACLPVILGCALLWKLPTSMQAGRILGFYLINFFSSAWVQCIGLGTSNVSGHTKKALYAAGTFVGYSLGNIVGPLMFDAKYAPRYDNGFIGLMVCFVVCFCVALLLRQALAAENRLRDREFGTQSDVGISDDLTDRENKNFRYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT67</accession>
    <name>A0A5N6TT67_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_140664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT67"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF162">
        <property type="entry name" value="SATRATOXIN BIOSYNTHESIS SC1 CLUSTER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="36988" checksum="B42F833001EE27A0" modified="2020-04-22" version="1">MSSSTAPQGMAAHVSATKLIAITWTGVALGLVFTTMRVVIRVRRAHGILVDDYFVIVGLILLITNAVLQTIQTPHIYSMLFGENIVHHTVLYTRYEFIIIGLFWSVLWSIKGSFLALFWSITAGLPGYRRACLATGLFAFLSYGGCWFASAFTCHPATDYFKFGKCTKPIDRKGSIISISYSTAVDILTDLIIMYIPLHLLHRAKITLRQKISLGFIFSIGCFIIATAIVRAVQITDKAYTDPVGLAVWGVVESSVSVIVGCLPPLKTWVSRSEREYVSRSQGATRIQSLAGSEEPPLPLEDMKLSIDESGRVRMTGSQNRVILNERSSRLVTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTL7</accession>
    <name>A0A5N6TTL7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_124472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742117">
        <property type="protein sequence ID" value="KAE8149647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTL7"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="345" mass="38089" checksum="9FCCB789E795E2DF" modified="2020-04-22" version="1">MPTVLLPSSAAAFAPRSSPNVVLNTRIEPWLTATLKRVSRVKRPLNNVTQHTRCLTETLSSSNAIWTLCSIMFPKAPDAELKKDENPLVEALFNYQMIHIEAYVVHVDMVSRNEVAFKLTPETIEALVDFHQDVYSVDTAANTWNWSEKESQLKKLHEEFVQAANKFVYRASAQALEGLEEDGAGELLGGRSEEAKNAISSLFVPLLPPPPRVVNVLRSTPVLPSSTGSENWWHDPMQQPVSMDSWKVLPSSPAMASTTDQNPNLWSSVNLNEFTYASPTPSYSQPYTTSPYNATQFYSTAPLPGVLAAIPFPSTLIQPCATAANMVGFGWGDRIHELPLPYGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTW4</accession>
    <name>A0A5N6TTW4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_156127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTW4"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="74"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="296"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="495" mass="53574" checksum="0929B3EDA6AD1131" modified="2020-04-22" version="1">MVAPIRVAPSAANRALNLLRTVQYTHPPSCPCHSNPNHHHHHRTPTLADHVRRHMSTPIDPSRQKEYAFEMAASSIRFGPSATKEVGMDFANMKAKRVCVVTDKNVSQLDAMKQAIEGLSREGIEFTVFDNVRIEPKDYSIKEAIAFAKPYNPDAFLAVGGGSVIDTAKLMNLYTVYPDAEFLDFVNAPLGKGRPVDRKLKPLVAVPTTAGTGSETTGTAIFDLVSKKAKTGIAHRNLKPTLGICDPLNTRTMPSAVHAASGLDVLFHSLESWTAIPYNERTPRPTNPINRPAYQGANPISDIFSLQALRSTIQYLPRAVKDPEDFEAQSQMLLAATLAGVGFGNAGVHLCHGMSYPIASQNPGYKHAGYAVDDPVIPHGVSVAVTAPAVFRFTAASNPDRHLAAAEAFGIDISNVKRESVGEVLSEAIVKFLAELGDQPLGLKGLGFKSSDVESLVEGTIPQKRVLMLAPNLNEELEAEKAELRGLLEQSMDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU25</accession>
    <name>A0A5N6TU25_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU25"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="27603" checksum="C668129C8240BB26" modified="2020-04-22" version="1">MAVTEQLSADFVACFVFEKRGEKFIILKRFFPTADGVGYWAWDLPGGDMNVVTESSDPLAAVDKIEGVEFAVRYNQIENASQRQREHVAAHYEVEHHTGLQIDLVEPYTKVFNPYRPKADGAGFRCFTRFYTAVCKDEDPKPQIKNEAECKKLVWTTMQDLRIMFQAQTEVEKRKLDMRTYEDRLSKKLMDFFRTEPCPKDASRRAEPYDPGSPKVPKASDLYKPESPEFPEASQKQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUF9</accession>
    <name>A0A5N6TUF9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_118860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8150002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUF9"/>
    <dbReference type="OrthoDB" id="4936979at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.400">
        <property type="entry name" value="Calcium-mediated lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036684">
        <property type="entry name" value="Ca_lectin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="145" mass="16590" checksum="F7A8C50D8885447C" modified="2020-04-22" version="1">MQPESYMKHPENEPVVVSIPEGAKIDISGTTNADFHQRVTIKEIGKDDSYIFEGHGESAVMNLKTGGNRLAVERATGSGLRTWTFDFENSENQQEYRHSKVLRPVYKTVYNNDYKVSKMEWEIVSEDNVDDDYNDAIIHIVADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUL4</accession>
    <name>A0A5N6TUL4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_119299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="ML742107">
        <property type="protein sequence ID" value="KAE8149980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUL4"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="81"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="35219" checksum="6E20E70AEB85BEB1" modified="2020-04-22" version="1">MSSAIDESLKGKGQAAGGWKSWSLKKRLLIIGGGLLVVVAIALGVGLGVGLTKGGSDDGEVPPTSGGKVTTAEWQPKPGTTWQIQLLNPLNDTSLDVEVFDIDLFNNDKSIIDELHQKNRKVICYFSAGSYENWRPDKSKFKDSDLGSTLDGWEDEKWLNLKSQNVRDIMASRLDMAKEKNCDGVDPDNVDGYDNKNGLDLKQEDSADFMMWLANEAHARNMSIGLKNAGAIIPAVIDNMQWSVNEQCMQYDECDKYAAFVDKNKPVFHIEYPKGDDTNNNDDVTTQQKDKACEYNNKKFSTLIKNMKLDAWFQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUU4</accession>
    <name>A0A5N6TUU4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_154947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUU4"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="201" mass="22779" checksum="F74F7BD35ACBAE26" modified="2020-04-22" version="1">MAAINKIALNSPSRQNPSELETAIAGALFDLESNTQDLKATLRPLQFVSAREVEVGHGKKAVIIFVPVPLLQGFHKIQQRLTRELEKKFSDRHVLFVAQRRILPRPKRSVNSRTNQKQKRPRSRTLTAVHDSILTDLVYPVEIVGKRIRTKEDGSKTLKVVLDEKERGGVDHRLDAYGEVYRRLTGRAVVFEFPQSGASDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV18</accession>
    <name>A0A5N6TV18_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_117207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV18"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024839438" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="60" mass="6824" checksum="D81F7A680B26647F" modified="2020-04-22" version="1">MNVIVWSCSIVIIGLIVVLSRDGNRESSLFTDRYMLKMQQDINAPSEYTQRHAEPDPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVS3</accession>
    <name>A0A5N6TVS3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_172209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVS3"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="533" mass="59450" checksum="351034C4CEE68628" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVW4</accession>
    <name>A0A5N6TVW4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_111541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVW4"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="244" mass="26899" checksum="06157AAF4EC2D9C6" modified="2020-04-22" version="1">MASNPPGACCASGFKHEGTPVGETKNINGVDTYIVYPKDKSTEKVVVFLSDIFGIYINAQLLADEYAANGYTCVVPDLFQGDAIKISDMESGKADLPAWLPNHQTSHVDPVVESTIKYVREELGAKRLAGVGYCFGAKYVCRFLKNGKLDVGFNAHPSFVTHEELGAITGPISIAASEIDQIFTTQLRHESEDILKKTGQHWQINLFSGVSHGFAVRADLSNKHFKFAKEQAFCQAVTWFRQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW34</accession>
    <name>A0A5N6TW34_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_108278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW34"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000211">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="298"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="559"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="623" mass="68794" checksum="27340E861FD9806A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWG3</accession>
    <name>A0A5N6TWG3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF167 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWG3"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13737" checksum="50E76CBD940E1B6C" modified="2020-04-22" version="1">MSNATQFLRLVQNATKPRTKPPQTYNLQIACNVKPNASGNREGIIAIGPEKVDVCVAAVPRNGEANTAVSRLFAQVLRVPKSTIDVVKGLKSRDKTLCVYGVEIGSEGEEGFLQGVRGKLENAMIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWL3</accession>
    <name>A0A5N6TWL3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_154280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWL3"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="11756" checksum="04EC705967E136AA" modified="2020-04-22" version="1">MSCIKNEGESNAFPPLKHSPSLKGFTHLATDGVYRSFSSRGEVVDYKQLSPAEIASMLEFFEKHIDSEAFQKVKKFDGVDGRTVTDLEQLLHLGPDIRPVRFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWT0</accession>
    <name>A0A5N6TWT0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_106131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWT0"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000460">
        <property type="entry name" value="Armadillo repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000609">
        <property type="entry name" value="Armadillo repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109609" checksum="5FDF1457D391AC72" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWT7</accession>
    <name>A0A5N6TWT7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BDV25DRAFT_129508</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWT7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="68788" checksum="7A86C1D3A7BD3E4E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY25</accession>
    <name>A0A5N6TY25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_171596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742074">
        <property type="protein sequence ID" value="KAE8151283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY25"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="355" mass="37050" checksum="7CB25007E3DD797A" modified="2020-04-22" version="1">MPLYAFGSNGSGQLGIGHDEDVSMPTKCLFEYDPAKSTTPTTHPENRNVRRIAAGGNHTLVLFDDGSVYASGLNEDGRCGVRPGDVVGVFRRVEFTWEGRLYDSFTDVGASWEASFFVAGGRVFVSGSGGKGELGLGEGVGFVEGVREVGGLPGGVVGVSCGMGHCVVVLGSGEVFGWGGARKGQLGEGARGGKIAWRPVRIEVGLRVEGVACGREFTVLTGSRGEIEILGAEGDKWKILSGRPVLDGWQRVAASWHGVYVHLCEGGVVAWGRNDRGQLPVEHMPKVKEMAVGSEHALALLGDGAVVAFGWGEHGNCGPVADAQGNVREYMSIPLPGGKVVGIGAGCATSWIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYT6</accession>
    <name>A0A5N6TYT6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_128748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742070">
        <property type="protein sequence ID" value="KAE8151500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYT6"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="148"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="319" mass="36069" checksum="1D6ECB67DF43E6F1" modified="2020-04-22" version="1">MEERSRLRTYQLQTIQTAQHTNRSLVSSITSQNYASKHSPSSRRLSPCLMFSPLSTCHHGKPQPQTLAPFPGPHSNIRRSSSQLARAIMPRPGTAAETYVAYGMTQKLFEACSSQADYSIPQVSIKGAQVPKTEAGEDLGVGEGWWYEELGLAPTFSTWSQITFLHMYLLTVRLRALPSYESFQTYSRHLIDHFSHNAEHRMDVLHGFTSRTIRNKFLKDLFIQWRGLLAAYDEGLVKGDAVLGAAVWRNLWKASHAGPDGKELDWTRVARVVAYMRRIISELSQVTEADLIFQLRPRDGKPGIFGYSEVDKKLVDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U023</accession>
    <name>A0A5N6U023_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U023"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="371" mass="42552" checksum="9EFB63329AC9BC79" modified="2020-04-22" version="1">MLQSTLSAEFWKSIRGQTTTLPNLYLLFPNWEPRLHPEYLRARDEVFNPWIERWVANKATSRKFQKADFAFFAAIQCADASFDKLCTIAKHFAWYFIWDDLFDCGPLADDKSKLDSYRDASLQYLRAALCEKGEYPDLSCFSQQLQDSLRCWDEVAAHLREVCTRGTCHDFQFLNIQLAVVVHSNNTAETREELLNKHLFYASSMGVVDSVFAGGVPSLTKFWRRRERTAGVYSVIATIPFTYGIDISKQELSFDLMRLLWRHTSYLVHMTNDMSSLQKEIGDNQAESLVPVLMLNEGIDCDAAMRLAHQLVEESTRGFHEVEARMQCMSQRSPNPVYDAYLEGCRNVVMGLIHFILGNATSISRISALIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0Y9</accession>
    <name>A0A5N6U0Y9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Patched family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_151310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
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        <property type="protein sequence ID" value="KAE8152307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A5N6U0Y9"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:sterol binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024826145" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="375"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="656"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1126"/>
            <end position="1148"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8152307.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1270" mass="139680" checksum="7260B1C340E6476C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U113</accession>
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        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDV25DRAFT_170663</name>
    </gene>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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    </reference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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    <sequence length="329" mass="36797" checksum="3EB8CEA851993763" modified="2020-04-22" version="1">MTTFMASHPKLAGFDLVQTHYKKVDDHEIRADFILPQTEFHGKRPVIVHFHGGGLITGDSLSMEWFPLWLLDLAKKHNAVIASPNYRLMPEATSLEIFEDIEDFWTWLHSAEVTELLASSDNSTTLDLERIITAGESAGGLLSVCLEFAHPDKIRAATANYPCLDMNAAHYSTPNPTPLTNPPIPESLVDEYLAQAKPGMVRSSGILPDRVDLMLAAAHYGRLTQLYERGCEGFPKRELRYPMDRLDQPDVQFPQGGVFIIQGLQDIIVPAEDNKRFLTKAQEVVKGKSVADKITLVMREGSHGFDADISLNEPWLRESITATVESWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6U1A5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_170889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="573" mass="64164" checksum="E0F85F7878A9D92C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1C2</accession>
    <name>A0A5N6U1C2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_69954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1C2"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="529" mass="61032" checksum="E3FE0C9B5C48D5B5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1E1</accession>
    <name>A0A5N6U1E1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_151118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1E1"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000072">
        <property type="entry name" value="AT09463p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="34768" checksum="AA7EC3B18191D1C7" modified="2020-04-22" version="1">MSLVAVGACYVDTILTTPHYPGEDEKLRASSISRRRGGNCPNSLEVLQQLTAHGRSMTGLSLDLVAVLPAKSSIASQQIQSAFEPRVQLSHCIYREKFEEPASSYIFKSQSTDSRTIVNYNELPEMTIEEFKRIADELGPKATWFHFEGRIPDVTLACIHYLRQRFPLVRVSVEAEKPARPGLQELAMEADVVFYSKSWTQGQGYLSAKECLEKQSSIVRKASLLFCTWGQDGAVALDMETGNLIHSPAYLIADSKVVDTIGAGDTFIAGMLYGLNCQQESWDLSQKLSFANRVAGMKVTQEGFSGLDGALELNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1P9</accession>
    <name>A0A5N6U1P9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_65576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1P9"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF45">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="13"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="50489" checksum="A04B6D3F03A0E411" modified="2020-04-22" version="1">MASMEPPAVAGQADRFCDPSLGLAIQWIYLMTFAVVTIIHVTASVLIMRYWLDPEIVHSGVWITMFMVIIVGASYWGSQYMGYYDYILSSVKITVALGLMILSLVLALGGGPDHDRKGFRYWENPGAFAGENSALGRLRAICRTIPSATFSYLGSELIGIVILHTWNPRRAAIRAIRLTFCRILVINIVIVVLLGMLVPYDEVSLAFSKTALMKAGLSKVESREKGVTASVADASTAAAGFVVAIQIAHVPVLPHILNALLLLFVLSAANRSFCMAIRLSHGGAIRQNAVVVFSQTDIRGIPSLVLIVSALPMMFLAYLTLYENLRLVFKSLTNFVAMLNILTWITILVVHISFLRRGPPNEQPDRSEGSTAFKAPFGIYGSAAALGFCILIVIVRGFDTSEPHGHVMFDLADLVLSYLSIPLYLMLIFGHKLNSWRKKRRAISQDHDLQTVETSTEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U263</accession>
    <name>A0A5N6U263_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_150975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742052">
        <property type="protein sequence ID" value="KAE8152499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U263"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="180" mass="19679" checksum="5BD1BDE76EFC3531" modified="2020-04-22" version="1">MQGTAIVWIPACYPVASNPGPDAACPSLRNGSTAFLVSDCLGRGRLAPLHTSTMQSRNFILRYTRDRVSSLACLSIASLAMEPGSRTKRVGCITLTLITYDQVFTASASFIITGLRHSSPYLQVTGRCDEALWRVYRALIVRRPLVRYASAYFRVKLTSKLAAPCNTYSVLQGSTGLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3L3</accession>
    <name>A0A5N6U3L3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3L3"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="108" mass="12576" checksum="1E99A48987E872D7" modified="2020-04-22" version="1">MQISQPCKDYHWIPHLFMYIECCILSFLAVDYLLNMPLLETLFSNQGTGKKRFDMNILHLDKKNPRVYVSMNSTHVYILLPSIVTDCWAISRGTILKTASIRLLLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3U4</accession>
    <name>A0A5N6U3U4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_127423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3U4"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Berberine/berberine-like" evidence="1">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="354" mass="39420" checksum="09DB7E2E10AA8A31" modified="2020-04-22" version="1">MTTSSIDEQLTALRSLLHPEIITPTPQTASPPYRRLVSTTSLSATIAYLHSTTLGFATYSHGFMSASAKDVLVNTSAFDDFHFNEESETVTIRAGRTWAEVHTKLEDTAQDTGSSSTMARASTEPELLWALRGGGAGYLYRFVVRPRDIWAGPILVPWECLEQVADGIERFVSGPVDPRITMFLYVVEKRLLESIGVASDMLVIHAFDAHGEAHGRASFQWALDVPGAVDQTGHIVKGRMKQFWAPLLREITKETTINAVRWYDYIQSTDESLSECTDPVGPVSSCAWRRPVGAGYILLLGTGVLGNHAELHYLPNGLEDFHDTHKVYWGPHFARLQRLKRQYDPLNRFKSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3U7</accession>
    <name>A0A5N6U3U7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3U7"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="333" mass="37008" checksum="57BB6380DB903BF1" modified="2020-04-22" version="1">MVEERKKLSHKAYTVTWICALPAEQTAALAMLDERHYSLPTPLHDDNAYILGHIDRHNIAITCLPSIGTNSACSVLTSTVHTFPSIRYALMIGIGGGIPSKVRLGDVVIGWPVDEYEGVVEWDRSVLKGGERFRCVGSLERVSGGLEDAVDELARGEKLGERIRACLDATERRYPRLMPRYTRCEGLVDTGGVWRGWSVMAWIVFWVIYLLLNPFTTIGKRGSVYVQEMQSERREVRVHYGLIASGNRVVKDAKSRDALDEMFGGQLLCVEMEAAGLMNVFPCLVIRGICDYADARKNKSWQGYAAMVAAAYARELLGSLPVSSEDDMEIDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3W0</accession>
    <name>A0A5N6U3W0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_47716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3W0"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="314" mass="36384" checksum="5EC080318ED38CEB" modified="2020-04-22" version="1">MLQWLVPRFLLPDYTWSTYTPTTLSDRLPPVSQPAHPHVRRFWGIVHPYLRRFSRSYCGWVGIAYDNQIAQLPFGLILKWSDGTRIEEVLTMEVARKAGLPVPRVICYGEHPDTPHAPISILMTRVPGRELGQVYETLNDEDKASVCQQLDQYLKTIRNWQSPWGESRICSLLGTPLRSVRVPNHLAGPFESEQELNNYLREPAWLGGFPSETAYSDALNRAKRMDEKPHRIVLTHGDLQHHNIMVYEGHITGFLDWESAGWYPGYWEFTTPLRFAQESFWWYHFVVALGGKSYLPELDCERALTSLTSASYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U456</accession>
    <name>A0A5N6U456_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_31668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U456"/>
    <dbReference type="OrthoDB" id="4451832at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.440">
        <property type="entry name" value="Domain of unknown function DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50118">
        <property type="entry name" value="Cell growth inhibitor/plasmid maintenance toxic component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="62" mass="6700" checksum="9081C70796C98937" modified="2020-04-22" version="1">MRASVGDTVELSNNATRDRSQCEIIEVVGVNGAPPYRVRFSDGHESLIFPGPDAVVRRGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4L7</accession>
    <name>A0A5N6U4L7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_168749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4L7"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000095">
        <property type="entry name" value="Cyclin Ccl1, putative (AFU_orthologue AFUA_5G07030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="419" mass="46832" checksum="444092A26009CF51" modified="2020-04-22" version="1">MIEDDIYRTSSQFRLWSFTEASLQSLRATTNATACERVRSDIRKSRDAPQSASSSAAGTPAANPGSDVDSKAGEGSEDDCLTPAEEHQLVQYFCEQIIKLGEMYKPPLPTIVRATATQYLKRFYLTNSPMTYHPKNIMLCALFLATKTDNYYISLNQFAAGVPNDPKPDEIIRFEFLIMQSLRFTFDVRHPFRGLEGGIMELSAILEGLGKPAPHFPSQSPDELKRKLQSLSPPQGVQQGTSVQDRLARAHHGTREILKTAAQMTDAYFLYTPSQIWLAAFMVADRPLADFYLDTKLGGPVDENNKGNPFYELRVKLLRTLTDCANLLQSYTPPVSNQEQKNALRRIQKKLSRLQPRDKPEAVGQKRIPAAATDSGNSESEMERLAKKRKLDGAQANDLFGGELVMQRTKQTQGQQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4P4</accession>
    <name>A0A5N6U4P4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_149154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4P4"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="53"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="293" mass="32564" checksum="023700A0901028E6" modified="2020-04-22" version="1">MAQIKRLSQSLTTNTTVFSALAIFGIGAYCTRSYFLQSAHAESNECPVMFSGLGFTTLRVQSVKAVNHNTKRLVFEFPDQNARSGLSLTSALLTFSRPKGRWLPVIRPYTPISDLNHQGTLELMVKQYPNGKSSTHIHSLVPGDTLTFLTSLKGFSWKPNLHPQVYMIAGGAGITPIYQLIRGILDNPADKTKINLVFGVNTEQDLLLRDELEEYKKRFPGRFDYVYTVSRLEEEKGGLKKGYVTEELLKGVLNGEKDTKVFVCGPPAMEASLTGSKGILARLGYNKGQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4T9</accession>
    <name>A0A5N6U4T9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_169348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4T9"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="517" mass="56776" checksum="57DF5E86A911789E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U523</accession>
    <name>A0A5N6U523_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_168622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U523"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031594912" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="511" mass="55698" checksum="5930B497CD4261F2" modified="2020-04-22" version="1">MRLLNPLTLFAALTTATLIVHTDTGIYTGLHNPEYPSVREFLSIPYAKPPLASRRWLPPQPLPESNETHPPAALPPACPQYVTKRPTVFNQLATDFLIDNGNQSVTAGVSARHASEACLYLAIWTPANATTSSNLPVLVFYPGGAFQRGGVPVPYQLPPAWIARTQGHIVVTVNYRLNIMGFPNAAGLHDQNLGLLDQRLALEWVRSNIGAFGGDAAAITLWGQSAGSMSADWHTYAFHDDLIARATFSQSGTGLKTIPSDDYKHTNFTFVAKNLGCESDDPKQELECMRRVPVSKLQDFIGRYTDNGTEPALEFGPIVDDEVIFSDYPARAAKGLIANVPAIISNAANEGAALYKFPSDNITAGPWQPAINAVTLDDWLCASANTSVVRHNAGLKTYRYQYAGAFENISPFSWLGAYHCSDLPMLFGTYPSHNVSKVESETSRVMQDYLFAFASDPEHGLERMGWMPFEPGADGGGVMKRFGGSQGPEEDVFGDEVQGACWGRGEYDPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U549</accession>
    <name>A0A5N6U549_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_168291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U549"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="617" mass="68570" checksum="A07E34BD177147B0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U568</accession>
    <name>A0A5N6U568_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_149387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U568"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="472" mass="53046" checksum="3EF1BF4E1B0DF3B2" modified="2020-04-22" version="1">MDVQYEVPPQQVDKEFHYNFPTEIERSLTSVFAPRNILIVGAGIAGISCALALSKELTPFVPDLQITLFERHDVLSTSGGAINLTPVAQRHLDRLGVLEELDKMGSEGGTDVDAIEMFSARTGRPLGNIDFTDANGNGFGGYKGRRVMRIILSVAMLTVVERTKNIKMVYGKKLVRGEENEDQATLHFQDGTTATGDLVLGCDGVHSATRTHWVSPDCPSEYTGISFVQTVIDTNSIKSPIHFRSTSMNISRHGSLLASFCDREHEQIFLAAIVQFNEAHLPYCRIENGQDFVTQHRIKNLLHDQMQSRFGRSGIPCIREMATKSGDWMLYPVYQVRPGARWHTDRALLLGDAAHAMPPRDESAAYALDDSILFSRILAKHRHEPLPVAFKAYEDLRRNTVTTAFKASRRMWEKNRDLGFLEGRLKEWTLPFYIRNSKEQREAAWEFDATKITIPAPVEDSSMYSFGKSDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5N1</accession>
    <name>A0A5N6U5N1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_148658</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5N1"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000004">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8153906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="794" mass="90680" checksum="2C45CAFA94F5E58A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5T8</accession>
    <name>A0A5N6U5T8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5T8"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="27536" checksum="80321155FE7097C9" modified="2020-04-22" version="1">MDKHGQLALLIRRVNFRDVEVAILLNSREHNERWRNSPPEEEACLIPDILDALKDAPDHARGTNPSKSRGGSDMRSITIVEPLQLLAASPHKRAEAALVANGLPPYLIASEARSIIPFSATSCDVQDHLAQISSRTHWNASDQQEASAVIAPTAPSVALPLQTLAPGVAPEQLSSFTQVLTLHLSRFAQGQVEKGVIPSDEMFQQEARRLLYDSEDSWNQTIADNPEWLSAFRGLYCGNENESPETGGNVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5U7</accession>
    <name>A0A5N6U5U7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5U7"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="43534" checksum="1A3D0F16A41E27B2" modified="2020-04-22" version="1">MQKDESQENWLCAAQEMHDLLCSYGFEHVSVDIIDWRLEEGPSIFVCEPTDIIFSKWDMVRRRILDSVDTSGFQMLGCHRMCYESRAVDCKPTVLVTVNPKFERDWDIAKQDISNILTDFDLPGVVVQIYKDRGIFCVGQRSIEIATIGHSVSARDSSSYGTFGGWLNIRQSPDSEWEPFAGMMKHVKDGDSALHNRLHPSESAEEADCPSYGEIKRHIDVFKQTVSELQREEPYRTLEKLRADGDLPDELKEKWQKHRAHINSHEGSLANLEAYSESKMHRYNMLVTTFFTVAENGKQHATDEHSVLRGLEKAFFEPGDSGALIFKKTGAMVGMGFGGQVQGQVSVFTHVNDLIDDIKDQTGVDQVTIYTQEWPIKGSEGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U625</accession>
    <name>A0A5N6U625_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_1232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U625"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="626" mass="70166" checksum="2EBE409831AC6C50" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6K3</accession>
    <name>A0A5N6U6K3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_126742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6K3"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="38687" checksum="2007D2766B4C704F" modified="2020-04-22" version="1">MGIESFDNTVRVSAAQARSFALSVLQHHGVPKDRAVMVADALVLADLRGVDTHGINRLSGYIQRIQHKVLDPNPVLSFVMKTPAMASLDARNTFGFVAGCMAIDKGVEIAERFGMAMIAVKNSNHYGMGATYVLRAVEQGYAAMAFTNASRAMPPWGAREALLGTSPMAVGIPGGREGDFILDMSPTVAARGKIRKAARRGESIPEGYALDEHGRPTTNAEAALRGVMLPMGGPKGSGLAMMMDIFGGILTGSSFAGGVKNQYEDFDEPQGVGHWFMVFKPEAFLVSRDELDDRMDTLLDRARSCDTAVGVDRIFTPGERSSETEIRRRREGIPFTIAEVENLKELAKESGSDVTLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6R8</accession>
    <name>A0A5N6U6R8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6R8"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39371" checksum="1E54E7890E0A012B" modified="2020-04-22" version="1">MAYRRIRIGFIALILLILFSLNSQSLLRLYYLLRLPFVWTSYSTESIITQQDDGFDLTFSAYGTNYTTLNEGISPLIPARIHHIHLGHAPPPKEWISARSDCLRHHDKWEPFLWTDDNAVDFVRAQYPHLYDMWKVYPYEVQRVDALRYMVLLKYGGAVLDYDLACKRALEPLRRFEFVAPAAHPAGFSIGMMLSAPDQAFVKDLVNNLPVYDQVWPFLPYVTVMFSTGCHYASTIMTLQSNRKNVRILSGPPEHPKMHMLNGLVDTPLFHHLGSSSWHGRDVRFIAVFKNLDQRALFVGVLVALGRVIICGLLCCAKRRISWVEDEEHQSLSFAVEERKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U766</accession>
    <name>A0A5N6U766_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U766"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="406" mass="45148" checksum="FE362C8BF3BC5112" modified="2020-04-22" version="1">MALTTVSALLRKYAIDPRTIGRLEVGTETLLDKSKSCKSVLMQLFGENADIEGADTYNACYGGTNALLNAVHWVESSSWDGRDAIVVAGDIALYDTAAARPTGGAGCVAMLVGPDAPLVLEPVRASYMKHVYDFYKADFQSEYPLVDGHFSNSCYLEALDNCYQGYRSKMLRRARDETNGVDTDRSFLDTFDYIVFHAPNCKLVAKAYGRLIFNDFRLEPERFDQVPPEIRDVEYTASLTDKSLEKLCMGLTKGRFSDRVETSLTAPAHCGNMYTASVYSGLVSLLSNVPSERLQNRRIGMFSYGGGLASTMFSFRVKGDTKFMSQQIRLCARLDSRTAVSPESYDQVSRFSTGISKPRSDRCRCVNFVREPISGRTLSLKAKSIVSRQVHIIWSTLMRSSDGSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7H3</accession>
    <name>A0A5N6U7H3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_171809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7H3"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51264" checksum="6AD75A4E35B8934D" modified="2020-04-22" version="1">MPWSQLSTHTFTRPLGPNEVFIKLVSDPGHALGREHWAINYTVTISPRGDLTNLSSLPDLIRYAWSHLRFQHPSLAAYPDASNAVYHVPDSADALQEWLSQSFFVIDDAKSADEVIPTIKPAAYARLYYIRTAKQLLLHTAHWRMDGVGGPLLLGQLIDLMVLHSKTALSGPLPDPFDAFPWGEEVSRLTPPVEEAGDMPETPTEEQKRIAQEAVSTFALAAGAVGVPYTGDASTPPAGTLAAELTFSPSTTAAVIATAKARGLSITAAVHASLAAVNFRRAIPAHQGRHYTSTIKLSLRPYLPEPYSTPVAASGLYTSGWLARVDQNSTWEDHARTYQAEYQKGISAQYLQAHREYATLLVNILRNPPTPPEPPSDVDISSMGVMEKFLAREYGTAECGFEVTHVGVGVEMLTRQGVVFVWTFRDRLVLRLVYNEAYHTAEQMAGFVDDVRRDLLERFQVDERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7K0</accession>
    <name>A0A5N6U7K0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_147569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7K0"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="238" mass="25225" checksum="2F64337EC096DC8F" modified="2020-04-22" version="1">MAPRKALIAITSAHAPLYPEGKETGLFITEALHPFNVFKKAGFDVDLVSETGTYQPDWLSQQKDWLPDEDRAVWEDHSSEFRSKLDKLLKPGDINPDKYGLFFASAGHASLIDYPDAKGLQGIAGKVFADGGIVSAVCHGGAIFPGIVDSSTGKSVIAGRKVTGFTTRGEEEEGVLDTIKSWDRPTIEASAASCGATYVSPAGPWDAFTITDGRIVTGANPASAHVTAEAAVKAFNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U814</accession>
    <name>A0A5N6U814_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_82012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U814"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8154775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="415" mass="45961" checksum="260B358F7BBC4563" modified="2020-04-22" version="1">MNSLRQLTCREARRSGATGRVLPFQSTPTNRLWQRCFSVTPRIASQLAGLDPSKLTITKTTTPKELVSAKDLVFGKTFTDHMLAIEWSASKGWETPRIVPYQNLSLDPSACVFHYAFECFEGMKAYKDKKGQIRLFRPDKNMERLNKSSSRIALPTVDQEALTRVLGEFVKLEGRFIPDTRGYSLYLRPTMIGTQKTLGVGPPGSALLFVIASPVGPYYPTGFKAISLEATDYAVRAWPGGVGDKKLGANYAPCVVPQLNAASRGFQQNLWLFGEEEYVTEVGTMNLFIALKNKETGQKELITAPLDGTILEGVTRDSVLGLAQERLVPDGWTVSERKIRMSEVAEAADEGRLIEVFGSGTAAVVSPVRNISYRGQMVNCGLQENEEAGEIASKMKQWIEGIQYGDEDHPWSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U897</accession>
    <name>A0A5N6U897_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_147075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U897"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="68" mass="7333" checksum="EECA47C590CE8889" modified="2020-04-22" version="1">MYSATVTGEACGRGSPREMVMRAVEECAAEMRAEGAKRGCCRTRLDGGWGCMVQVAGDREGIMRDRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8P8</accession>
    <name>A0A5N6U8P8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_135342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8P8"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8155005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="38658" checksum="AA880797BFE1FF11" modified="2020-04-22" version="1">MNQENRDRPVGKRKPGMTASHHSILDQHEDEEEDIGPNRRLFLARPTWKVAPAGISKTRNQDWNRPQSNIWKTLATFWSFFVMGANDSASGSLVPYLQSYYGLSYIAVSVIFLSPLAGYVVAGVVDTKIYLTMGRRGVAIISPFCHILAYAVNCFHPPYPVLVITLAFAGLANGLADSAWNSWTSNMDHASQLLGFLHAAFGLGAVMSPLVVSSLTTQAGVQWYYFYYVMTGCAFIELITSLPAFWDLTGPGAYYAQAGDLKKSINHTNSGLRETMFKIPSAARVSWISSIFLFIYAGLELSLSGWIVTFMIDARKAGQFASGLTATWFWLGLTIGRMILGFVTPFYHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U966</accession>
    <name>A0A5N6U966_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_146602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U966"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34721" checksum="5F3398C4CEBD551F" modified="2020-04-22" version="1">MTMLLSYCSLRFSRLSIAGTIAFWCIVLLVYIHPIRLFTLEDTKSSGVLSGPRIPERIWYKIGPKGHDLQSREWMDDCLRKNPTHRAEILTDQLGERFVNESFASRPDIIETYFSLPLPIHKADFLRYLILYAEGGIWSDLDVSCEDVPISNWLPAEFQERANVVVGLEFDVGWGDHIFRQFATWTIMAAPKSPHMLRVIDDIVDAMREVTQSGQLPTNMIDTVVDFTGPRRFTRGILESLGSAVNGTISPDSFTHLLEPKMIEDVVIMPGYSFSASVNKYDPSDVVGPPLVKHHYAGSWKNANGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U969</accession>
    <name>A0A5N6U969_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_126156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U969"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="432" mass="48713" checksum="00EB3EF7B83DAC80" modified="2020-04-22" version="1">MHSSFSSSACNTIHNVEYMPIDDVEKLERYRPGGYHPVVIGEQLKDRYCIVHKLGFGAYLTVWLARDQQSGKYVAIKVSVSSIDHVSSQESNVLRRLGTVYSKANAHPGEALILPMLDEFLLSGPNGTHRCLVTVPGMMNLADAKDASCTRLFQLPVARGIVAQLIQAVAFLHSQGIVHGDLHEGNVLIRLPESIDTLSQEQLYERYGQPHHEPAIRLDKGPLPQGVPTHAVVPVWLGKESKLVSLPEAQVFLIDFGESFMPLKSKRYHSNVPDTLVPPEIRFESEKPLSFPSDIWTLACTIWTILGQRPLFEGYNPSSDCVVKGQVDTLGKLPLQWWLQWDSRARWFNEDGTRHSGANARPLVQRFRDTVQEPRRKCGMGEMGLEEEIALFDMLHAMLAFRPEERLTAVEVMGCEWMQRWALPELTRMKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9D0</accession>
    <name>A0A5N6U9D0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_146348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9D0"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000240">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8155224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="544" mass="60231" checksum="67D846F2CFA35B14" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UAA0</accession>
    <name>A0A5N6UAA0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_126050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UAA0"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8155101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="391" mass="44529" checksum="BEC81FFE9AAD5834" modified="2020-04-22" version="1">MNGVCLPRQVRRLIPGALTAILFVSYLSITDTFGDLSGGFSYRSCETHSRIPRKIWQSWKVDPLEFEERDLLVARSWTSKNPGHRYEVLTDQNDLYYVETHFGPEGFNRPDIVDTYRSLAAPIIKADLLRYLIMYVDGGVWADIDVEALRPLDRFIPDRYDERDIDMVIGVEIDEPEFNSHPILGQKSQSFCQWTFMAKPRLPVMMRLVEHILDWLHDLSVKQGKPIAELELEFDDIISGTGPSAFTAAVLAEMSIRTGREVTWKTFHNIPESKLVGGFLVLTVEAFAAGQGHSDSGNHNARTALVKHHYHASGWPTKHPRYNHPVYGEVEQCNWNRDCVAEWDANTAAFASLSPDEQEQQIALKKALESDVGDAEEPMWDVNQAEEPEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCX1</accession>
    <name>A0A5N6TCX1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_167645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742927">
        <property type="protein sequence ID" value="KAE8144106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCX1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="172" mass="18915" checksum="2BC60A93DA06C7BF" modified="2020-04-22" version="1">MAHQGSSRSFRPIAPRAVPDPPPPTPGGGPPEEVKIKRASAACTECKRRRTKCSADTTGAPCAECALHGRECVVDEYADKRRKVAARRAQEELRYYRGFVEQLLKAIRYGDRPNVDAIVNIIRSGATLEEIRLAVRESLKKDLTVDEDLPDALGQGIESDEVTKDSTPDAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDC1</accession>
    <name>A0A5N6TDC1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrpF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742543">
        <property type="protein sequence ID" value="KAE8144384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDC1"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="381" mass="39706" checksum="A0729A127A74E537" modified="2020-04-22" version="1">MNLRDKKQCSLSAAYYRGGTSRAVFFREDDLPPDRKAWNSIFLGVIGSPDPYSRQLDGMGGGISSLSKVCVVGKSQHPDADVDYTFVALGVKTSEVDYSSNCGNMISAVGPYAVDTKLIQVPSEATEASIRIHNTNTGKIIRATFPVVDGEAASDGSFAIDGVPGTAARIQLDFLKPAGSRTGKLLPTGNVTDTFDGVTATCIDVANPCTFVRASDLGVDGNLTPDEIETYPGLLPRLDIIRRQAGVRMGLASSPEAVPGSVPKICLVSAPAGDGRAVQQKQTASHIDVLARAISVGQPHKAVPITVALALASAARIPGSTVSKCASEKPVDEAGITIGHASGNLLVGADFTADGALSAATVYRTARRLFEGRIFWKGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDS7</accession>
    <name>A0A5N6TDS7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_91733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="ML742494">
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</entry>
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    <accession>A0A5N6TE63</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="10 11">IBT 18842</strain>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEG1"/>
    <dbReference type="OrthoDB" id="4157036at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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            <end position="73"/>
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    </feature>
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            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
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            <begin position="48"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="424" mass="46513" checksum="C1568799F00E4057" modified="2020-04-22" version="1">MARFIPTASKRLAVQPSKSIVEESLKRPWWQAYLLSDIYIPLTKNGRRKEDSPEMSRSSTHDHRQTASLNDADTAWTNPKWLGNLMSPASPVLPSYPPPVRAPTPPGLPSFGTEDAIRYTSQFTVDSAAQPQPSEHANEINKAGSYGQILRRFFRVPASVSRSNRRVDSVARAVDGTAVQGRFPYRQSAHGVSAGGRLDDHPFHRRTMPVAQCDSVNVSGDDDASASKSQSATRRHAIHSNRDVASTLPMERGLSLTPECVSASTSSMPPMYRCESHHASVSLQQRARTAVSTTMDPLPEAEPADNSTAITQSPQDVTLLQGDISIDGSPHSWLESSKIMASCFGCCLRARNEQDMAVYSNVSSNDTYTTARSQFSRESTPQKGRCNSIQEVGRWCSTIRASFQTFCASLSGSSTWLDQAREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">C6 finger domain protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">BDV25DRAFT_166169</name>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742446">
        <property type="protein sequence ID" value="KAE8144729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF20"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="358"/>
        </location>
    </feature>
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            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144729.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="85467" checksum="0B4999AD0331E306" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF80</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8145025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF80"/>
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    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="122" mass="14156" checksum="6EBED6B653C2438F" modified="2020-04-22" version="1">MHYIQVSLKIKLLVQKTMNDNNQPSLPIMNNALSGLVLSLLPKDTILHRHRSKFPQDSHTHTQESQESIFTKARLGTARANKYNNKHKKHREEDNADKYYITLFLLIAILLDMIIAARFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFR5</accession>
    <name>A0A5N6TFR5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_144993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742390">
        <property type="protein sequence ID" value="KAE8145080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFR5"/>
    <dbReference type="OrthoDB" id="5421702at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="40180" checksum="453F1F4BE7BBD102" modified="2020-04-22" version="1">MDQTFTRDSISKRKDDCMHSVVTYKLDDVLTPVSNLGCMKCIERADDDLDILSPTISFNWADDALESMLEEYIDFDNESFESDSDILYELNDSIRRDDCIRDKEFDELAKETSSGTSHTDSIIQPITFSNTIHNSLPSSVDDLYDECIDSEDGIDQDVASEFSFRDTYVQGDSGKETHHFNWLGSPVFESSLTPATISLLFQLAPPKNPKLGDEIWFEGIMRRAMTYVDPVIVYLEKGIEDLTRRGMDLVQFATGRTYKLYSPHGRWILDELEWDEGTLLDDGSMEIYTTRHVVCGNGITTYGGIRTRDRWESDKTQLYQASTTSAYKFRLKLRNRVYRPSPLRQVLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGA8</accession>
    <name>A0A5N6TGA8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_164871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742355">
        <property type="protein sequence ID" value="KAE8145356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGA8"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="606" mass="65186" checksum="861C247B08B7EDF0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGH3</accession>
    <name>A0A5N6TGH3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_164720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742347">
        <property type="protein sequence ID" value="KAE8145426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGH3"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="219" mass="24559" checksum="E2547FA12C98B84E" modified="2020-04-22" version="1">MSLFRAGNIACFRAGRLATPINARFVSTNTGRGDPSVKTSPADAPAVPPKDSSLIRQEGPAEGMARHQPDYEATIDHGTSKFSPVPKRVMDGSEPGETVPAAVLSGAPTDLQARTVRIFRPAKPATQSGTWHQHHWRMDWDVLQKGHRWENPLMGWQSSADCMQGTHLNFKSKEDAIMFAQKQGYEYFVQEPNERRFVPKAYANNFLHEHKKLKHIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGV5</accession>
    <name>A0A5N6TGV5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_144752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="ML742358">
        <property type="protein sequence ID" value="KAE8145331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="11">
        <location>
            <begin position="727"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="1382"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1137"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1325"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1696"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="140"/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742325">
        <property type="protein sequence ID" value="KAE8145649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THM9"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="110" mass="12514" checksum="525042C0FFE4CF1A" modified="2020-04-22" version="1">MNTSSESPSGSSGARTEKKKRPIYACLPCHKRRVKCDHLKPCTPCCLRGTPSQCEFTEEGSNAHMLQSDLIKNLTEECAYLENRLAELESQQPNTKERCKSDKYIYFSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THU8</accession>
    <name>A0A5N6THU8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_59000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="ML742299">
        <property type="protein sequence ID" value="KAE8145948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THU8"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="350"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="485" mass="54329" checksum="B29276FDF1B80C48" modified="2020-04-22" version="1">MASQSNSMSIAAPEVAATAANSAPTQNTRPSRPPRPNYRHIHRFPLPLSVHPLPPLIPHNPISIVSVLLSYLTYLISPPRHEVHSAYFDPDTSSVHVTDPKAIRALWEMGFFGKGSLSRSEPSWLEREKKRRGLLGGVTSEEVTRQRRTERRELKLERARMEKLAIEQRLKAEAAARETGDASAGDTSAEQPLLSSADGVTNDPLPTEKFSLRKAREAKMLESQRSVVQAEEKSTPNSTGQMSPSGGKTVRFSPVVQAKEFAPDSTVLHVTESVGDEHGAEDEPLLNNEEHLQLSNEEAFFLVYGLGALQVYDDKLNAPLSVPSLLSLFCQHSRFPPCHPSSDLDLDDPFMISYVVYHHFRSLGWVVRSGVKFGVDYLLYNRGPVFSHAEFAVVVIPSFEHPYWSATEERRAHCASKQARSWWWLHCVNRVQAQVKKSLVVCYVDVPQPTSGDIQALSGDIGTLLARYKVREMLIRRWVPNRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI40</accession>
    <name>A0A5N6TI40_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BDV25DRAFT_57993</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="ML742292">
        <property type="protein sequence ID" value="KAE8146023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="12" id="KW-0010">Activator</keyword>
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    <keyword evidence="13" id="KW-0804">Transcription</keyword>
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        <location>
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            <end position="397"/>
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    </feature>
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        <location>
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            <end position="967"/>
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            <begin position="1342"/>
            <end position="1492"/>
        </location>
    </feature>
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            <begin position="1"/>
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            <begin position="452"/>
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        </location>
    </feature>
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            <begin position="1553"/>
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            <begin position="1624"/>
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        </location>
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            <begin position="1"/>
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            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
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        </location>
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            <end position="215"/>
        </location>
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            <begin position="462"/>
            <end position="475"/>
        </location>
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        </location>
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            <end position="535"/>
        </location>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146023.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1650" mass="185949" checksum="16F59B07FDFE70ED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIV5</accession>
    <name>A0A5N6TIV5_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024879880" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21004" checksum="16F9287D25DCE39E" modified="2020-04-22" version="1">MKFLQNCSFLAVLVAFSNAISIPSRLRSEEHHQISTAEDIPELPEGFTWRIVEHPVGIDTRISRVVELETQSNQLQKRAFAIGCVGHPGSPPLIDDCNTLNTQVQNYQSTLLVQPGYCHEATYGTCLTYVCAKCRQVAMDTNKWYDLNQAVISHCVDNGEAGYGYDNTDNEYEIGIEHSGDELPSYIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIX6</accession>
    <name>A0A5N6TIX6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_162785</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742273">
        <property type="protein sequence ID" value="KAE8146282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIX6"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025000263" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8146282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="401" mass="43802" checksum="1321C25872CCE38D" modified="2020-04-22" version="1">MRFAVLAFAAVYLAGLADAQKQSLPQCSLECLNDLLPKSACAPTNQTCICTDADFQEQLETCVSENCTIKESLTTLNVTNTGCGAPIRDQTSPSIIIPAVGLGVLLFVGLRIYTRVVVTEANLGLDDWATILLGCCIVPVNVGSILLGKAGLGKDIWTLEFGSITRILYLYYIQELLYIFCVSLTKICFLLFYLRIFPSAQTRKVITISGIITICYCIAFMIALAFQCFPISYNWNAWDGEHTGKCVKKNTLVIAAAGLNIVLDAWVIALPIPRILNLQASISTKLQVVIMFSVGFLITGVSIYRTIMLKIFATSTNATWDTAAGGYWSIIEVDVGVFCLCMPAIRSLLGRMIPSVFGSTKDTNEGNSASQQKPLKVVKTTSLTQLIEMDNMGVERRQDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ44</accession>
    <name>A0A5N6TJ44_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742285">
        <property type="protein sequence ID" value="KAE8146121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ44"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="113" mass="12969" checksum="F48018BF38CBDC9E" modified="2020-04-22" version="1">MTVKHEGPQKKICSVSGWKYLFFCLPCYFFSLFPFCFFFPWAGSFGFFKKKVVGALGLVTAIDQNINPPCLFLVFFRDSLGTKMGRSAAEGEKVDFKRCQRTVKRELERAAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ90</accession>
    <name>A0A5N6TJ90_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_143753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742266">
        <property type="protein sequence ID" value="KAE8146387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="565"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3189"/>
            <end position="3265"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4735"/>
            <end position="4808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="4808" mass="534724" checksum="D19EB1AAAEDB9BC0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJA4</accession>
    <name>A0A5N6TJA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_52428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742270">
        <property type="protein sequence ID" value="KAE8146330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJA4"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="45"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="435" mass="47635" checksum="4C5B3D291DE8C73C" modified="2020-04-22" version="1">MSDTLPQPPLNLARGWPANNLFPRQNLQDSAVAVISNPIVSAQGLGYGPDEGHFELRKNIGTWLSRNYGLSKSIEAERICISGGASQNLACVLQVFTDHIHTRYVWLVEPIYHLAFRIFEDAGFYGRLRAVPEDENGINIDFLERAIQSLTPDSVSSTSERPYGKTYSHVIYCVPTFSNPSGTTMPVSRREALVRLARKHDALIIADDVYDFLDWTPSAAPGSTRHPLPRIVDIDRTLDGGPATPFGNSTSNGSFSKIVAPGCRVGWAEGTPEFAYALSQAGSTRSGGAASQLMSTFINDMLENGSLDKHIRDALLPTYSRRALTLEKAIKEHLLPLGVTCGLGPEPRSIQGGFFTWIKLPHSLDARDIADRAAQEQNLSVAHGNIFSVPRGSHPGNDLRCRIRLCFAWESEELISEGVERLALVLRDALAGLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJP8</accession>
    <name>A0A5N6TJP8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory lipase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742254">
        <property type="protein sequence ID" value="KAE8146567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJP8"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025102213" evidence="2">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="46021" checksum="E4F6219E9BEAE90F" modified="2020-04-22" version="1">MMPRLRIFIQLLTMATVLVGVHINRGSSFLPPSQDPWYAAPEGYEDTLPGTILRIRAAPNNFTAELGRNVSSIFNILYRTTDGRNHPSWAVTTLLVPSNPHPVNGTPSLLNYHIPYNSLNLDYSPSYTLVSHFSAAFNDILPSLARGWYVNIPDFEGPNAAFTVSLESAYAALDSARAAITANKGLSSHSRVAFWGYSGGAFPSEFGAELQAAYAPEIRLAGVAIGGLLPDVAKALRTIDGQPYAGLGPLTVLGLAARYSEVSTYLNHSLRFTGPFNRSTFFATRDMSTWQAYATFANQRIAEYFVHDLDWLAAPALQDSIARNWFMGRYATPKAPLYMYKAVHDEMSPIADTDALVRKYCATGATVLYERNTVGSHLDEYSNGNARAFAWIAGVLEGRDPVGCTVRDVNVTAPPLLEGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJT2</accession>
    <name>A0A5N6TJT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_169803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742254">
        <property type="protein sequence ID" value="KAE8146575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJT2"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50925" checksum="AFAB79F310A850F1" modified="2020-04-22" version="1">MPWTQVTENRYQRAIGENERFIKAIGDRAHAVGREHWSVTAYGTFTLHENVKRSSADVTAWLRQAWQVLRFQHPSIASTASDEILEYVVPAAQELEEWTRDTFTVVHDGTVDDVVASIKPSPFVTAYYLPHRSQIILHLAHWRTDGYGALQLLNAFFESCTALSTTKVEALPWGTEVERLVPSVEEALANPVESTEEIHAAARKYLATTANIPGAVGVSQTTELSTPPSGTRSARLRLSTETTEAISEACDARGISVLAAVHASTAATTYELAHPDAKQKHYTSTMRFSLRPYLPEQYRNPSVAAGIYTGGYMAKVPATQSWLDNAKLYTREYDTGVTDDFLISRRQYARDVFERMKTPPPPPVTPPSEIDISSVDDATKLVHPWHGTSDGKLEVNEVSVGVETLTRQMYCFVWMFRGSLELSVVYNQAFYEGGFVKGAVERVARVLEGNLGLVFGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKA6</accession>
    <name>A0A5N6TKA6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_143372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="ML742242">
        <property type="protein sequence ID" value="KAE8146794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKA6"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000053">
        <property type="entry name" value="Alpha-L-arabinofuranosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000092">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815580" description="non-reducing end alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="10">
        <location>
            <begin position="459"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="637" mass="69304" checksum="FEDC08D7D0C4D699" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKG5</accession>
    <name>A0A5N6TKG5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_169636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742243">
        <property type="protein sequence ID" value="KAE8146770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKG5"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062247" evidence="3">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="37"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="358" mass="38462" checksum="4B50BAEF9D9537A9" modified="2020-04-22" version="1">MLSLLLLLTLTLSITTAYPHHHHRSNTNISNPNTNPTQNTVYWGQSGSREKDLSSYCAPSSGIDIIILSFLYQYGNGQRQPGGTIGEHCKITAGVAQNCESVIAGIESCKVNGVKVILSLGGAEGTYSLSSREEAEAIAQNLWDSYGNSNPNPVPNGSWNGDANGNWNGNWNANGNTILRPFGKSFVNGWDFDIESNRGNEFYPFLIAKLRANFAKDPSNTYIITGAPQCPIPEPNMQGMIAQAQFDYLFIQFYNNPECSMEKVNFDAWAGNISTGASANAKLFLGVPAAPLAANGQEDGARYFFQPGVLAALVKGFAARPQFGGVMMWAAGFSDSSASNGCTYAQHAKKILRTGGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKH0</accession>
    <name>A0A5N6TKH0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_44505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742240">
        <property type="protein sequence ID" value="KAE8146837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKH0"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="271" mass="30577" checksum="F1E7D4B1A9F01BF6" modified="2020-04-22" version="1">MSSAQDEFNRLVHSNKETFSTHPEDRNHSDHDSDSSDGEDDLPQFSDSEDHDPTMRLRSSTYHVPRTVFEANTGPKGVIADAQAFERARQSSFRKTFLNNDPAKSIADDSTLLHNTPPPDGSASDEDEEYFIRKWRESRMQEMQSRGLRRPSPRRKMYGSVHTVDAAGYLDAIEKVTSDTVVVVCIYDPDSDASAIVEDCLDTIARRNPAVHFIKLHHEIAEMDYVEAPALLAYRGGDVFATLVEIIRQIPKGRDCNSNTLEDLLKSHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKI7</accession>
    <name>A0A5N6TKI7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_169769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ML742252">
        <property type="protein sequence ID" value="KAE8146611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKI7"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="647"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="726" mass="79327" checksum="7E7A877351557FB3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKT0</accession>
    <name>A0A5N6TKT0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 69</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_161486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742234">
        <property type="protein sequence ID" value="KAE8146952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKT0"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33004" checksum="9316CDA1B5BD9ED1" modified="2020-04-22" version="1">MLYRNFAARSVLRAISSSNASVARSTLTNNVFKAPLSSSARYPVRPTTPSLALAARKPVTTALVRHSSSTPKEGEEDVDMMAGIKSEAKVIKDTFSLESVPKEALYLGMAGVIPYLATSLETVYLSYEINRAATLGDGLLFSGQSAELMLHMLEPIQVGYGAVILSFLGAIHWGLEWAGYGGKLGYKRYAAGVVAPAVAWPTLLFPVEYALISQFLAFTFLYYNDARAAAAGRAPHWYGMYRFVLTFIVGASIVATLIGREQIANTATEHTFKDKINALLFLQKKEKEEAEARRQAELEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKX9</accession>
    <name>A0A5N6TKX9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_43019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8146985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
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            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="199"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8146985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="820" mass="91758" checksum="B3F3DA1F55A61244" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL19</accession>
    <name>A0A5N6TL19_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_41247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="40299" checksum="F60FDBB79E4BC132" modified="2020-04-22" version="1">MAPQIPSFDHRLEENQPTDAQESKLLFLEEKRVRIENEILRRSILEMRDWYKERDAFIKESEQFKDDFWIRVFASAPAEIDQYVTTPDASALGSALKSMNVERFELNEKGEGEPRSIRLTFEFFTGEQNPFFENDKLVKEFYWRKRSVQTDDGRVKSWEGLVSEPVRIQWKKDMDLTKGLLDAACDLAEAEKKGGDRHDLPEFDILGNKVVELEAAGMENDEEDLDFPSSPVGVSFFGFFGYRGNDITAEESAAVTKKEEERFARRSKGEQVDEEEEEVDEDFEGIEVYPDGEKLAVALADVLWNQALSLFNNSLEAGSDLELEMEDLEDDEEDEEDEQEQRPKKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL20</accession>
    <name>A0A5N6TL20_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_41174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742229">
        <property type="protein sequence ID" value="KAE8147042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL20"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="176" mass="19861" checksum="AC572BAC01987504" modified="2020-04-22" version="1">MSHKGLSGAQVLRDRFRIGICCCWTGWLLLGLRSRSISSSVEVAAGQIGCCWHFSRIQSCRWVVEYVELVERSGLSHTESRLHLSIRRYKYGTTEAISITESNLCFFRCLISRAINKAERRVTKTEAFVSSTAKHRRKANTLTARAVGVCKNKKEGRMGKKGNWCKCERGSTPWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLF4</accession>
    <name>A0A5N6TLF4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_169392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742225">
        <property type="protein sequence ID" value="KAE8147110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLF4"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="6">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="348"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="616" mass="69478" checksum="2881DCE1D18C9626" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLS9</accession>
    <name>A0A5N6TLS9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_169256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742218">
        <property type="protein sequence ID" value="KAE8147240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="911"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="984"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1405"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1498"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1514" mass="162518" checksum="E22FB5FD7ACDAAF9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLT7</accession>
    <name>A0A5N6TLT7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_132179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLT7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="12"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="52869" checksum="24EA160507A89344" modified="2020-04-22" version="1">MGSLDSSILALLTIAICSTIFLISLDFSIIATAIPAITSEFHTLEDVGWYGSSYLLTTASSQLLFGKFYSTFSTKWVFLVALLIFEIGSALCGAAPNSVALILGRAIAGSGNAGLLSGALLIMTHSVPLERRPLFMAMTGGTYGIAAIAGPPLGGVFTDKLSWRWCFYINLPIGAVTFIRPVAETFIGRLKRFDPLGTIVFMPAVICILLALQWGGTAYAWQSGNIIALFVVFTMLLLACVIIQWRAQENATVPPRIIKNRMVWSCAIYQLTLGAGFFIFVYYVPMWFQAVQGVSAIESGKRNLPMLVGNIIATTISGIAVTAIGQFAPFMILGTILTPVGGGLLTLFNPATTTAEWIGYQALVGIGIGLGWQQPIIAIQAAVSIEDVPTATAILSFAQTLGGSLFISVAQTAFTNKLTNVLATTVPDLDPSVVLDGGAANLAGHVPEKYLPAVLLGYNVGLRHAYIVGTAMAALSLFGSACVEWKSFKGKKIETGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMA5</accession>
    <name>A0A5N6TMA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_160296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742206">
        <property type="protein sequence ID" value="KAE8147464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMA5"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000009">
        <property type="entry name" value="Pseudouridine synthase TruD/Pus7, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000007">
        <property type="entry name" value="PUS7p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="376"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="725" mass="80032" checksum="1105BF91D15D7A85" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMD1</accession>
    <name>A0A5N6TMD1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_160275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742205">
        <property type="protein sequence ID" value="KAE8147494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMD1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8147494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="242" mass="26178" checksum="224776EC45CE7170" modified="2020-04-22" version="1">MGIHMDDNIHAPTVASGPSSTGEPARDPAKLSMVDLMQEKQRIEEELSALSEVLGSHGVHMSTSLTTFDGFPRDDIDVAQIRTIRAKIIKLRYDHKEVMKHLETGVHAHFANLQRAQEPTSTINNTNGSVGASNSTTESSSSDTGMLSPPFAKVNSVAAGSPADQAGLRLGDTIRSFGSVNWINHERLSKVAELVQQNEGRTLIVKVSRQNEAGSLAELNLELVPRRDWGGRGLLGCHLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMI0</accession>
    <name>A0A5N6TMI0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="7">Ankyrin repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_169222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742213">
        <property type="protein sequence ID" value="KAE8147319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMI0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="384"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="660"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="867"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="966"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="130354" checksum="1519FA6EF0C0479E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMJ6</accession>
    <name>A0A5N6TMJ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAUS augmin-like complex subunit 6 N-terminus-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_31958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742202">
        <property type="protein sequence ID" value="KAE8147537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50056" checksum="A470B9D01E79C49E" modified="2020-04-22" version="1">MTHSQELLDAPDGSGLTWIFDHCLRYPASYELPLRTMYALNCNPTRQAPPANRAPETAFCNRPSHSSNSSVSSQDTPLDRAADFRALLTHQIARLPTQPCSLPPSFVTSFLRRCFTPDLGDVDFPQALTGLDYLKDLETRRRKEVAAAIERLRLTPDDVTNNKAELVKKYPNVLTWLEANNAKNRKAEALYTQVYIGIRRWTLINEMLLEPHNKANCIAMLNTLFPPVTNATAGPTAQLTPQILKSQRDGFFRYIAAFENNGRQILDSVIAQGAPEGESTGWPLVRDALDKYLQITNDIIDDCAMVNDQSSLKETADSQPRRKVDSGISFASSDDFRVPSLHSRNVSEDVVDKPLPPAPRESQSKSGGSTLERLTRELRKLSDAGKVKNLKKMKSASALTARSESISSHVPDNSTFFEIDEQKRKRLIWEATSRKRTHSKQSSRDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMW0</accession>
    <name>A0A5N6TMW0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1305"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1598"/>
            <end position="1880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1896" mass="212658" checksum="31C9438E4790E905" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMY8</accession>
    <name>A0A5N6TMY8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PinX1-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_159902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMY8"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="295" mass="32867" checksum="AFABB6A7C6B50924" modified="2020-04-22" version="1">MGLAAPRKKTKISQDPNNTNWSRSTSGFGHKILSSQGWTPGTFLGARDAAHADMFTAASASHIRVSIKDDTLGLGARAKRDAMDEPTGLDAFKGLLGRLNGKSDAVLAAEQRKREDVKVARYIATKWQTINFVSGGLLAQEKNVSQPEKDKDTNHAPENKPEEPFTDDNISPTQPCENHASSDVQQIEERRHKKDKREKKDRSEKKDKKNKPSKKRKLVDESDVADSDSVDKKTTDAYSKFSAGEARQGTLPSNTTLSKERRPMGRHVFRSRHIAQKKKALLDDKSLNEIFMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN16</accession>
    <name>A0A5N6TN16_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN16"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PEX14"/>
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        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="416" mass="44387" checksum="8B244858A246A486" modified="2020-04-22" version="1">MADSDSKPPSIPQWQRPSTASDDSTSTPSPSSDDTSRSALLQQATKFLQDDALRDAPLDRKVSFLESKGLRRDEIDGLLDRSDNGSTTQDHTSSESNNKESPSNDSASPSPSTPTVQSSSSSSGVTTTSTSTTPQNKNTQRTSSARDMPPIITYPEFMVKESKPPPLMSLSSILYTIYGAAGLGASIYGASEFLVKPMLANLTSARHDLAQTADENLRKLNEKLEQNVSTIPPQLTSRRVQSAGSTTDDDTESLTSDPAELFHRDVAVQTSDDIGRNSLSSSAPNTADEAAFDPAAAVNTHVKRLEVLRSHLQEFSDSEKQSSSSDNNVRTSLNELHHYLDGLLYSKSGYGPATGYGAYSSPAFDSSNNAAGLGKGEEDAISSFKSEIRGVKGALLSARNFPGGRGARMSGGFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNA5</accession>
    <name>A0A5N6TNA5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_142360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="216"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="629"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8147842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="863" mass="97511" checksum="C8C98EAA24711DD2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNV9</accession>
    <name>A0A5N6TNV9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742178">
        <property type="protein sequence ID" value="KAE8148038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNV9"/>
    <dbReference type="OrthoDB" id="4924482at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="117" mass="13133" checksum="D9ABB8C0C97AC073" modified="2020-04-22" version="1">MSNKRRVMVTINHRDRLSLREHRAQLGFAAYHWGILIQPKNTKGSDSSTYDVSDAAMPDPHTRVDHNPNRDWIFRPKHRVNAELSGRLLGRVMVGKVPNNVPDAHIEASSSPSAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP07</accession>
    <name>A0A5N6TP07_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eisosome component PIL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP07"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF4">
        <property type="entry name" value="PRIMARY COMPONENT OF EISOSOMES (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="483" mass="52117" checksum="3D8F253B33DD4E93" modified="2020-04-22" version="1">MNRLIKDENAAIGAYEKAGRVRVSVAKELSDWGEATEDEAVSDITDKLGVLLAEVGEQEDLFAAYLEEYRTVLKRIRETEGSVQPSRNHRTKIQDEIAKLKIKDPESMRLETLEQELVRAEAQNLVAEAQLTNMTRSKLKEAFDIHTAAVIERGEKQILLARHARRLLNILDDSPVVPGEPRRDYDRGDEATLIISEAEKDLHSWESSTVPIQTSAGNIPESTLLPAPAARRARESQALTSSEPGFDGTATSDSARDLRGSVSSPYTDGYEDQGDNGYAAATRHSAAYVPDIQERAEPVTVAQGLEEPVSGPARGTRGAPNTIAFIPGTRQRVGPDTETEGFGESSTRPVGDASRAGYNASDYNPGVLDNSTCIPGTKERIVLNSQADEVNELNEATDAAPSDVDEGIAGVGDAAESAASTRYATKDYDEPISDAGGIEETSQITEPTTDVNSMLAEARSAREKLQEQPYASSSVPQAVAVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP41</accession>
    <name>A0A5N6TP41_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_142290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP41"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="64"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="349" mass="39123" checksum="3D880E8C385F046A" modified="2020-04-22" version="1">MPPTPFFSLLDNLEALNHEDKYSAFHIIQATYKSSADTGSHITADILIPHTLRNTAGPGPRPVVVRIHGGFLVTGSGLYPPWFNSWILEYALANQAIIISPNYRLLPEVSGREILDDIHDFWHWLRNGSVVSIIQEKYRGVALNHGSTLVVGESAGGYLAVQLAISYPSQIRGVIAAYPMVDLRSRFYRESYSKPIVGVANVPVRVVNDHLATLTQESQRPWVTAANPPDRLELAFAITQNGRYLEVFGSADRELFPMERIEDLLSNGEKVRLPPMFILHGEQDSAVPVESSKKFVRFLREKLPQTTVMLYTQDGDHGFDAEATLETPWLQKRLDIISQVWLEPSSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP59</accession>
    <name>A0A5N6TP59_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_158920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742173">
        <property type="protein sequence ID" value="KAE8148143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP59"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="192" mass="21253" checksum="BC73087FC0F5B235" modified="2020-04-22" version="1">MERRSSYDQTYTEPSAVHFLPRRRQSSDNEPLAEGRKRRRLSHTHPTTGVSHPSQEDGDEAGSIDLTEVQGSSALSKVLAKQREDAVRAQLPVEHEEGLSALKSYKCPVCMDTPEDATTTICGHMFCHKCIIDTLKFGEEQRADAPGKGPRGTCPVCRKALSRNDAPGTKRNLVPLQLKLTTKKRSTIARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP75</accession>
    <name>A0A5N6TP75_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">Ribosome 60S biogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_25564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEAT_URB1"/>
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    </dbReference>
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        <property type="entry name" value="NopRA1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="632"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="876"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126325" checksum="5C92454186391F5E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPY9</accession>
    <name>A0A5N6TPY9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_141831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742162">
        <property type="protein sequence ID" value="KAE8148404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPY9"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF175">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE PKFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8148404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="46314" checksum="D60B27202D8681F2" modified="2020-04-22" version="1">MPYTRKGRTLPLVFNTRDEVLHKRLKTPIANLYSLSNILTFEIYVDQTLEVLFAQLDHRFSSSQQVFNLGDWLQYFAFDAMGTMSFSRRYGFLEKGRDDKGLIKAIWAFMKAAAPMTQMPWLDLVLYKNPVVTLLKPTASQPIMEIVSSRIEERQKELNSSNNTDKGTRYKDFLARFMCIRAKKDTIPIWAVTAWSFPNVIAGSDTTAVAMKTLWYNLLMHPTNMHSLRGELTQAQQQSKLTLPFPSWNEITHLPYLDACINEALRIHPPIRLSFERIVPAGGMTIGGYFFPEGTVVGMNPWVINRDRAIFGIDADIWRPERWLEDPVRTRTMENTLLSFGTGRRICLGRNIALLELKKLTAALVLNFDMEIVTPEKFQAQNFLFFKQEGLYVTIKRHSNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPZ5</accession>
    <name>A0A5N6TPZ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_158297</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="16 17">IBT 18842</strain>
        </source>
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        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8148422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK13343.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="195"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="556" mass="59825" checksum="290B8E47D09082A9" modified="2020-04-22" version="1"> </sequence>
</entry>
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    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        </location>
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            <end position="242"/>
        </location>
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    </evidence>
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        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
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                <person name="Wiebenga A."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="Mortensen U.H."/>
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                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="76"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="265" mass="29079" checksum="8A09DA52124CB47F" modified="2020-04-22" version="1">MTSAFFKVGDDFEKIQAARPDFRREAEVTFSKPPNPSWQPGDGANDDGESLEKSHIEIDPHEEGRPVASNYKLLISGMVPRPIALISTKSKDGKTANLAPFSYSQVINHDPPLFVVGFVGPLEKAKDTLKNLAETEECVINIISEHFVEAANATAINAPYGVSEWEISGLHQAPSSLVQPARVQESILSVEGKLVETKEFESRTTPGKKTGVLAIIEGVRFWAREDAINEDKSVVDLKVLKPISRLGGIQYGRTTDAIEIPRPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQF2</accession>
    <name>A0A5N6TQF2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_19463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQF2"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="59"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="229"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="399" mass="44760" checksum="487C2B2C18DE382E" modified="2020-04-22" version="1">MDPKAIQKLLEDVQTSLNTYQSNPTETSRVEAQEKALNLSRALERPRDAILKISYSPTIVMAIKVAHDLNVFPTLAKATSPVPLNDLAALKPADPLLVERMMRLLVANGFAEEPFPCEYLPTALSKEMTQRTSIGVVESIFLEFFPAIQKVPEYLEVIGYKNPEDPLFAALQYANNIKQDGFAWLCENPAALSRFNAFMEGQRADRAHWADWFPIKDHILTGAHKGADAPLLVDIGGGRGHDLLGFKQRVPEAQGKLVLEDLPKVIEEGRTALDLESEGIESVGYDFFAEEQPVKGSRVYYFRNIFHDWSDDKARLIIKNLIPAMERGYSKVLMEEYILPDKNARSLEGMTDIAVMVFCSGLERTRQRFTNLLESAGLKVNKFWTREGDGQGIIEAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQI3</accession>
    <name>A0A5N6TQI3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_158421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQI3"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8148381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="153" mass="16792" checksum="6CC888CF5B03535D" modified="2020-04-22" version="1">MGSNLPYAADAESPLKAAELQVLRSQYEKEGDYVGIQTKFNFAWGLIKSHTRADQQEGVRLLAEIFRTAPERRRECLYYLALGNYKLGNYGEARRYNDLLLDKEPANLQAASLGTLIDEKVSKEGLVGIAIVGGLALAAGVVGGMVFRGAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQT6</accession>
    <name>A0A5N6TQT6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_131183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742158">
        <property type="protein sequence ID" value="KAE8148501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQT6"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="94" mass="11157" checksum="12B50E9587624A13" modified="2020-04-22" version="1">MATKTRTIRQRRVDNAKSRYQQRNRRMSSLFLKAFEYCHLCDADMSIKVRLRHNGEIVVFNSNDNWSPTQAQLATYYPKPKQVTWQELAAKYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQW8</accession>
    <name>A0A5N6TQW8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_12448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQW8"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000219">
        <property type="entry name" value="tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="234" mass="26577" checksum="5E297FC8C5120FDB" modified="2020-04-22" version="1">MSSSDLPSEKQEAYEEKHVHEVYQQIANSFSSTRYKSWPIVEKFLKDLTPGAIGVDVGCGNGKNLPVNQNVFIIASDRSENLARIASRHQPHSAIVADILNLPHPNSFFDFAISIAVVHHLSTQERRVQAIREILRTLKPTAADAPGGKMLLYVWALEQKTSRRGWDKGDEQDIMVPWVMKGHPKSDSNEQPKVFHRYYHLYEATELEHDISDAGGRVLESGYDRDNWWAIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQX3</accession>
    <name>A0A5N6TQX3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Peptidase family M41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_12547</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQX3"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
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        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
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        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
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        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_lid_3"/>
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    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
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        <property type="entry name" value="FtsH"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M41"/>
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        <property type="entry name" value="Peptidase_M41-like"/>
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        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="426"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="839"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8148700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="878" mass="97984" checksum="35D0C923DE542CE8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRD2</accession>
    <name>A0A5N6TRD2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">High osmolarity signaling protein SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_157820</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742150">
        <property type="protein sequence ID" value="KAE8148691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRD2"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 19" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="401"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="197"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="586"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="727"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1035"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="790"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1090"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8148691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1141" mass="123270" checksum="06530D9B69A16796" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS66</accession>
    <name>A0A5N6TS66_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="4">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_7738</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="4"/>
    <dbReference type="EMBL" id="ML742138">
        <property type="protein sequence ID" value="KAE8148999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS66"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.140.10.30:FF:000003">
        <property type="entry name" value="Probable dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025007609" description="dipeptidyl-peptidase IV" evidence="14">
        <location>
            <begin position="16"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="103"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="557"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8148999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="770" mass="86976" checksum="442AD99EC2046695" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS79</accession>
    <name>A0A5N6TS79_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_141094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742133">
        <property type="protein sequence ID" value="KAE8149147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS79"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="583" mass="63778" checksum="4EB47304F09C1CC7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <name evidence="5" type="ORF">BDV25DRAFT_157015</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="452" mass="50924" checksum="72DA19F6316092B4" modified="2020-04-22" version="1">MPGPTERGTLQLLWSCTSTFILCIWTAMHPNVVPVRGVFPTGFYKAALMIVAVLLPEMVLCMAAAQFFHAKDVHIAWKEKWADWRNRNQGRRTGNNEEEWLGLSGAFFVVMGGFVVDTRKGGASPLVTTITGKGFIELLENDTIQSLVDSGELKKEHFDHFNVEDKGKASNIAKAIVVCQATWMAVQIAGRKASGLPVTLLEAHVAIQILYSVTAYIFWWKKPLDVAEPISIPLDESYLGSHDPKMKTRGDIRDQSFITEDNQIWSATHMFFRVAHDVSMYLGGRVELYSAITALINCALHATVWNSHFPTTTERLLWRLSVAGIGLFPTITYVITVSNRLDRYLLKWFFSTRSYSKNIICRPFQVAQGLWYIRLEACGLRDAEDGRRIEPEGWFGKIHPCLRIVLVDIVILSTSLYLASITYLTIEAFISLRSLPAGSYSLPIWSHILPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="551" mass="61454" checksum="C443F77B628D8670" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTL2</accession>
    <name>A0A5N6TTL2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742115">
        <property type="protein sequence ID" value="KAE8149702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTL2"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="26873" checksum="2A23DF4994E71B00" modified="2020-04-22" version="1">MPLTLHHANPTDTPYIADLFFASFANDPPVEKLFPRAPDVRDWWIRAISQDCRNPRKRVLKVTDEGGKIIGFVLWSLPASPDQVDMDDGFSVPWPGSCDAEYGDRFFGAIHEREMEVMRGKKHYCILLVLFTLVLLSSLNCYRDPLGLMLTVIIIIDVDMLATHPTARGRGVATMLVRWGLRRAESNGIDVYLSSTQMARSVYEKLGFEARGLLLIVEGYAQIPMVWSPGRICSDAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTR4</accession>
    <name>A0A5N6TTR4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_155707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTR4"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="157" mass="18201" checksum="835C19B73BF4D423" modified="2020-04-22" version="1">MFAGKRLSKELLKLKEHLPPGISIAKSENLEEWQMDIRVLDENPLYQNQIYRLKFTFSSRYPIEPPEVQFIELPTTSETPRPIPIHPHIYSNGIICLDLLSSAGWSPVQTVESVCMSIQSMLTANTRDERPPGDSDFVSYNRRRPRDINFFYDDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUI7</accession>
    <name>A0A5N6TUI7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUI7"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="66"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="353" mass="40250" checksum="5F8CBF5F73C58058" modified="2020-04-22" version="1">MQGKIALEEAFEIPSKADQSRDQAALYIAPNDLDRYLRQIKSVTDERVQVSDAHGIGYTVVSHTVPGIQGIRDRSEAESHARTVNDYISNEIRNHRDRLGAFAALSMHDPKQAGEELRRCVTEHGFHGALLNDVQHAGADGETYLFYDQPEYDAFWKVCVELDVPVYIHPAAPQGLYYQQQYAGRRYLVGPPLSFANGVSLHLLGLITNGVFDRFPKLKVIVGHLGEHIPFDFWRINHWIEDVERPLAKKNGDRMCERDIYYYFRNNIWLTTSGHFCTPSLEFACSYLGPERLLFSVDYPYEKIEDGCGWWDGQKEEIAKALGGKEAYVNVGRENAKKLLKLGKYHDSEKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUM0</accession>
    <name>A0A5N6TUM0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fermentation associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_155093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">IBT 18842</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1602" mass="178288" checksum="6EE070A0549A346E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVW2</accession>
    <name>A0A5N6TVW2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OG-Fe(II) oxygenase family oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_154822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVW2"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="207"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="43386" checksum="0DF10E931F851E45" modified="2020-04-22" version="1">MATQTESVVNTIPLTKATKPLEKYTHHPESKEDLKYADLVTIDLSEFDRPGGKEKLAAQLKTAVHEVGFFYVTNFGLTQGQIDEQFAIAREFFKLPEAERLSFRAPLEEGIYNGYRPLGSIEILPGLRDNIEFYNIMKFLPQYDRTHPDVIRQYWNEIEKFHRHCHEHIAYKLFRLLAIVLELPEDELENGHRYEANCDSGLRYMMYRARSPEENEKFKNLYSRGHTDNGTITFVFQQPVSALQVKKHNESDWEWLRIQPGTLSVNVADIMTMLSNGWLKSGVHRVIVPPEDQRHLERLGLLYFVRPSDRLKLKSVNSPLLRREGYHKDTTDLDIPATEWTRERIKKNWSRSPTDLEGKVSLGGFNAKLFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVX2</accession>
    <name>A0A5N6TVX2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_154430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVX2"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000001">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="406" mass="44256" checksum="736403A79BDB25C6" modified="2020-04-22" version="1">MSQPLRQSVGAVSWTRVLPPRARQGPSLHQTRCVQIRAAPAEQPASGSGNNLPVVNTPNSAESADARFDVIGAPYSLLSVNLSASQNLYTRRGTLVGLSGKADNVVSTLSILEPFRRAVVGVPFLYQKVSSASPVTALVSVRSPVTSFAVVHLDGSVDWMVAQRRALLAWTGRSLTIKPTINTNLSLAHWGSSEVTGRGLLALVGTGQLYQVEVKAGEQYIVHPSNVVAYTMTSNPPRPYRFKSTTLKFQVPRLKELPSFIQDSKFIRDMSDSNAWKSAMRIFHKVRTWSRMTIWGDRLFLQFDGPATILLQTRGPRINEILSSREVNEIASTPRGLTVGPANPADTKKLSADEEYRKAAEEAVNAAPVPSRSVEALEQEIKGSAQSIATLTKEGKVIFEKPGQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW68</accession>
    <name>A0A5N6TW68_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_129396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742089">
        <property type="protein sequence ID" value="KAE8150633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW68"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="26543" checksum="0C76CE2649021EA4" modified="2020-04-22" version="1">MTFENVVPMEIVFEKELYSCEFSVIFLILLRSQTCIMKVHRGRGPRKYYEPEDRELDIHVLEATAYRRLKEQGLCDRGIVPQFLGTLEKFDPRQCRPFLDAFIDDEYLPSAIFLEYIPNMEMIHLHNCTEKRLDGLVRGIREIHAAYIEHGDPRPRNIMVFDDDPERVVWIDFDRADTYDKEQITDEQKERLSEEEAIVLGLRECLELDLPKGKLKEAYIFYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWL6</accession>
    <name>A0A5N6TWL6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_153849</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWL6"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000004">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.620:FF:000004">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000290">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="15">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="14">
        <location>
            <begin position="148"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="13">
        <location>
            <begin position="211"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8150775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="322" mass="35636" checksum="FB881BB1F0F5407B" modified="2020-04-22" version="1">MEQQATLNSIQKGVWDGSLPLQIRLAPSESRIYDQTDPYLIASPRISYLPSLLPRLRAFFSSFLINPDSHPHDGWFSFEGVPLKWHLPLGLLYDLYAGAEPASKAMNDPDDTDWDLDNPDSVLPWRLTVHFSDWPDEELVRLDADGMVMNDAFINSVKEADFLRNGTAKGIMSLSKEDSSGLWKSVQNVDLASFQRISNILLPPPNQPFRNIPIRIFLPLPPDSGSPALKVVQSPIPPFIPPSSMATSQLSLSRSSAAPQPQTMGTTLHSLLPNLFPSRRTPVLAKPVLHGAAVPMSAPIEEVVRCSAYGDGWLYVVIRMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWW7</accession>
    <name>A0A5N6TWW7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_108802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742091">
        <property type="protein sequence ID" value="KAE8150561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWW7"/>
    <dbReference type="OrthoDB" id="4948898at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23424">
        <property type="entry name" value="beta-trefoil_Ricin_BEL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053237">
        <property type="entry name" value="Natterin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244:SF5">
        <property type="entry name" value="NATTERIN-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244">
        <property type="entry name" value="NATTERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="383" mass="43910" checksum="539F37777025ED15" modified="2020-04-22" version="1">MDDYWWNEDIEDLPWDNDVDQPEESDGAAQSKLRDAQLKESAAAFDAYYQNSLDNMWDEWQQDCAKGNAMFNNVYHPPPGVSFRLCHYKLDQCIYARDHNTPNTGRVWRAGQSYPDQYFHLVYDMGGNAWAFKNAQTGKYLAAGPQANSNVGHTPALGDKTRVFLQPVKNKKLKGYFKIIFDNDDFQSMLTLSDDHDTFYTVPTDQAETEHHYWYMEYEDMEFFKIEWDDTKARIGSQEVVSLWSESFMNESNVTQQSEINEEQSIEQTSEFGHLFGASIGASVEAKVGLPFVAGATVTASASANTELKWNKISKWDKKYSLKTTFNWPANSYMKGSIVVRKGTIDMPFMVKYKSVSTGEEICSWGLWRGVMSYDQARRLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWX6</accession>
    <name>A0A5N6TWX6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_153627</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWX6"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8150888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="181" mass="20911" checksum="396995BE069C4893" modified="2020-04-22" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKQIMNEDVTTVSPTLGFIIKTIEFQGYRLNIWDVGGQKTLRSYWKNYFEKTDTLVWVVDATDRLRIDDCRDELAGLLLEERLTGASLLIFLNKTDVEGCMTENEVRKQLDLDSIKTHKWLILPCSAMTGKNLHNGLEWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWZ0</accession>
    <name>A0A5N6TWZ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_153520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWZ0"/>
    <dbReference type="OrthoDB" id="5387214at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="168" mass="17982" checksum="6057E3DEC023693C" modified="2020-04-22" version="1">MASTLAAIGNQLTSKDEKRIGSPTKGLTAVPEAEALVPPTSPVEDYDPTIGAKPFSPFYRHATPSITLGRLGLKNKDSAGATKNATDIEYGERCRESGESGNRRESKLWKEKKRHCDWLRNLPRGQRMVIKAAIAIGTVGTMVAIALGITVAVGGGVWRSDHQQSAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYJ6</accession>
    <name>A0A5N6TYJ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYJ6"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="652" mass="74804" checksum="7C3803030CC2A636" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0C4</accession>
    <name>A0A5N6U0C4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosinase</fullName>
            <ecNumber evidence="2">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_151700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="2"/>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0C4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="560" mass="62954" checksum="50B7B95026BD61F0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0U8</accession>
    <name>A0A5N6U0U8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0U8"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25742" checksum="3CA15A96AE4442B9" modified="2020-04-22" version="1">MTQQDKYTDPDLREEIKEEIKQSDKGGKPGQWSARKAQFTAAEYKKRGGDYTTSKEEGEGRDESQRSLEKWGEEEWQTKEGSGTARMEDGSRKRYLPARAWEKMSEREREETDKKKKDESREGKQFVGNTEVAKKKRKEVQGEDGGESEDVNVDGKEGEGEDENDQDEELQDGEAEDQDKEQGDEDGEGAEPGKKRTAKQKETPNKKPRTRQDSKAEREQGEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U158</accession>
    <name>A0A5N6U158_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN3</name>
        <name evidence="15" type="ORF">BDV25DRAFT_151863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U158"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <location>
            <begin position="27"/>
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            <begin position="57"/>
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    <sequence length="659" mass="73165" checksum="113F47E6C184DC39" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1F6</accession>
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            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">IBT 18842</strain>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="KAE8152398.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="171" mass="18882" checksum="F35675174CA6039F" modified="2020-04-22" version="1">MRTSTLVAASAGTILTGLLAYAVYFDHKRQTDPDFRKSLKRNNRRLARAVKEEAEAQGAMERESIKKAVQQAKDEGFPTDLEEKEAYFMGQVARGESLCAEGSDKVEAALCFYKALKVYPQPKDLISIYDKTVPKEVLEILAEMVAMDAALKLGTFTGEGGSADEENHNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1X0</accession>
    <name>A0A5N6U1X0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">BDV25DRAFT_59989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1X0"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="300" mass="31618" checksum="E3592FAFC917849C" modified="2020-04-22" version="1">MEPLQNSVIGPLQPYLRPVVSSLPEPVHDAIISLIGSTCHNALVVDLDVTKDPACTSLAISKALGIAIVGASAIVKVPQILKLIGSRSSAGVSFVSYALETASLLITLSYSVRNQFPFSTFGETALIAVQDVVVGVLVLTFADRSTAAAAFIAVVAASVYALLFNQNLVDAQTMSVLQAGAGALSVASKLPQILTIWREGGTGQLSAFAVFNYLAGSLSRIFTTIQEVDDKLILYGFIAGFTLNVILAAQMLYYWKTPTKPKKEKAAPKPVQKKAPVAQNSSASPSPKPSGKTPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U265</accession>
    <name>A0A5N6U265_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_57344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U265"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="202"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="446" mass="49280" checksum="B4A33BAA54A62A35" modified="2020-04-22" version="1">MMLLYPGAKRYKQSSKDGGTKASGASITSMNTSKGSRSSTENPKKGSSQGKAKGKMANTGNMQKTSASKDSKSKSKESEKRAPNVFEYLDSDSDEFSEDDITIDVPRVSKYSSKAPHIGARLPTQGATNHGHMKPRRSMESYHTDKQNLDLTSIPESYYPSQDASSLHNPHFPPSPPQSPEDNLHNVDTRQKPTPQPVPSGYGSLARQLSSSVDKDEPSLSPLYRRFEDINHRVLLYLQDEIAQMEEELRVLDEYDEMHRVATAEQEGTSILPASRRMDAQAHMYSSLHYRREEVMATLIHKTQQYNTSLSAYSKVMQGLPGASEKDVDTYRAWIKKHNPIAAPETNFLDYTKDLVTFPRRPTARSGSVFSTIIIASAAILFPLIAFSMIAEFSGRLLVVAMAGGAASAIASNMSTGTDQLVASHDGWRIAALYFGFMTFVAMFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2F3</accession>
    <name>A0A5N6U2F3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_150421</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742047">
        <property type="protein sequence ID" value="KAE8152813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="599" mass="69420" checksum="62F2131B387436EE" modified="2020-04-22" version="1"> </sequence>
</entry>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAE8153465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="59" mass="6695" checksum="83D83DA8479021A6" modified="2020-04-22" version="1">MLFLDTTLLPYSPIETLLNPITSIWPWLVSKISSDGVLDSDQSDPLVLRPQQEREIKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U566</accession>
    <name>A0A5N6U566_ASPAV</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U566"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="66" mass="7100" checksum="E3E7B59F85DD1EAC" modified="2020-04-22" version="1">MKPTILFVAGAWIVPGFYFLNTIQAAGYLTVSAELASLNPADPATSDCAANAERIEHQFSTPIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5V2</accession>
    <name>A0A5N6U5V2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
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    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="166" mass="18544" checksum="835BDE18669421AA" modified="2020-04-22" version="1">MTANKDDIWSADTYGNKVAPFVATLTEKIVSWLEPQPTDQILDVGCGEGVLTAKLSQHVNRIVGIDASPNMISHFQTTHPTIDCRVVDCRYLDSDSELTTASFDKVFSNAALHWILRDPTTRLNCLRGCFEALKPGGVFVTGWFWKVCLSKKQEMPRLGGFQPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U634</accession>
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        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BDV25DRAFT_126727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8154042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U634"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30315" checksum="6CAD9AD9ABDCC731" modified="2020-04-22" version="1">MLIPTITRLTPFLNTIRINSPRKNPTRTRMSSSTSAQAAKIIQDTPDFEEKELQRPDFIHDKPITYGDGVLTTPSSTSKGHREIDPYAPDRAMINNYRLLVSAVAPRPIGFLSTVNKKGEKNLSPFSYFQVIDHDPPMFIVGFSSRPGRAKDTFANLQETGECVINSLSENMIEAVNATSIDAPYGVSEWEVSGLTEAESSTVRPGRVLEFVFSVEGKVVDEEGSHVELEKLRPVGQLGAVAYSRVMEVFERPRKRWSEEVGKSEVLKGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U657</accession>
    <name>A0A5N6U657_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U657"/>
    <dbReference type="OrthoDB" id="3941259at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38980" checksum="1E92EDE33175D50D" modified="2020-04-22" version="1">MALAAVRRSSVSGQRVLENLLKDRGESLPITDRIVSAAAEQRNNHALAIDILFEYRASLVVSERVLLAVFRNELWAIRIIDRLVGKQVDITVTETIMEAAVQNRMGYYIIKCLLQYNIAFPVTEQIMLSAAMNTQGDDIIKIFLQHQLDLVITEKVMTTIVRHLRYSIVLPLIEHISQYQQDLPITEQVLASATRNRTSACDVVILLLQYQPRLSITEQVVATAAENALAGYDILMILSDYSADLPITEQVLTMIAAAESSGTRIIEMLTMLLQHQEDMPITEQVVETAAANHAAGPNIIKTVWQHQVNQGKSLPVNKRLIRDAVWESRDKVEIRKFIKDAKKCTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6B6</accession>
    <name>A0A5N6U6B6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_136111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6B6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="52961" checksum="B57312903A234191" modified="2020-04-22" version="1">MLSLATSIKRQTARIASLCDRNRTSTVEIMMGGTRFMPMEILDQIVFYTALSDYDLQGLDGEEPVYSTATLKKLRLVNRQFYHSASRLFFGSIVLHLGCMKRSKFDAFAGFCQKENSRHIRDLKVFAKNSKMHRRLTEAHAARIAGYITRCIEQLQNVRYLSFFGADNCPVLPGKDALRHELRVANMIINALHRSVPLLTGLCLHNLDGTVIARFSGKDNPGMAAVISRLQSIELDVRDSGSSEAINLNEIFQHAKSLRWMCLVRVGTIRDMVIHPDAPLQTIRFSKLEISSTCFSNIIRRYEATYKEVALNEVNILRDNLWRWPTTLNTSKLDIDDSSPHVSMTEFIACLNIIGEARASGDKAILSPQPYNQPGILRQLPYTLKLRLDTPIFRLDAATPIPQAERRSVLCRRGDDSIRWLPSAYETYTEPQDKEDDRPERNPNYHSQFRRLAESGTAALRLLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6F6</accession>
    <name>A0A5N6U6F6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_121412</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6F6"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
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            <end position="422"/>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="460" mass="52172" checksum="398A8EC7C47368CE" modified="2020-04-22" version="1">MSALKTSDSPPIDDGTKDYVPLRGKYDPKKPHTSEQPITWTNWHQHINWLNVFFILFIPLLGCIGAYWTPLYRRTAIFAVVYYFNAGLGITGGYHRCWAHSCYKATLPLKIYLAAAGAGAGQGSIRWWSRGHRAHHRYTDTVKDPYSVQKGFWYSHIGWMVIKQDPKRIGRTDISDLDADPVVIWQHKHYIKAALFMGLVFPTLFCGLGWGDWIGGFVYGGILRVFFIQQATFCVNSLAHWIGEQPFDDRNSPRDHVLTAFVTLGEGYHNFHHEFPSDYRNAIEWWQYDPTKWSIWVWKQLGLAYDLKQFRQNEIEKGRVQQLQKKVDQKRATLDWGTPLHQLPVMEWDDFVEGAKSNGRALVAIAGVIHDVAGFVKDHPGGRTMISSAIGKDATALFNGGVYQHSNAAHNLLSTMRVAVLRGGCEVEIWKRGVDGKTPMVDSSGRGIVRAGDQVTRVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Z9</accession>
    <name>A0A5N6U6Z9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Z9"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein Ligatin/Tma64, putative"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PUA_eIF2d-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
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    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
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    </dbReference>
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    </dbReference>
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            <end position="635"/>
        </location>
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            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
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            <end position="70"/>
        </location>
    </feature>
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            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="651" mass="71851" checksum="3FB11C21E9C95B23" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Q4</accession>
    <name>A0A5N6U7Q4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135806</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7Q4"/>
    <dbReference type="OrthoDB" id="3489571at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841931" evidence="1">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="103" mass="11006" checksum="FEBA76488A23A7E5" modified="2020-04-22" version="1">MKASFTFLIAALAAGAVADLHYTGFCVDTDGGVDAYNRAATEKACAAYKNRNTGSKQWDTCPDCTVKSDQDILYYCDSAAQHIGGDELNYYCKQNGAGGSLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7X9</accession>
    <name>A0A5N6U7X9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7X9"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="165" mass="18660" checksum="28CD31F8C2ABD555" modified="2020-04-22" version="1">MPVSRSSALGSKRKAQEGLPESQAQKPRLVQADCAFDQCWHETDLQRPGLISIQAILRNHHRRRLYVRPIAWVADHLRLLECYFRRIGSGGNCEESRLKASRKGESYHDTGDVSSRMSDDFPRRRLVENKEAILAAGRLCRPTSLAVKKLAVETILGTFNNIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U986</accession>
    <name>A0A5N6U986_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U986"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="399" mass="46554" checksum="BC33D4D059F1C9F7" modified="2020-04-22" version="1">MGRAMNKKTMKKKTVKKKPIEKKPIERTIEKGDVEIMIPDAHFQAAQVEISDERNWIEVAKHPKFGKYAALIEDIKPLPCNYQVGVCKSKRARDYGMPPNIHYHLQHIRRHIGDGPQLKLYRTTRYLPNYKESSENHKNIDDKVFITMCDKRLPDAPSGDEPDGYSSCGGRLPECTVKIPNLGWMIDSYTLGLYHDGLPVQEGEKKPKHPLTYRKHAYRALHSIFTFYLPKPGDMVEGDVQTWDSILEEVHPGLRETVDYLCKNWEFEPTAFRQEDIEQAKKKNVETDNSHCAKKAINAKYVKYGRTWDGYDFKALYESNMKILRERSTELDEVYRSKEICFYEETPKGRYYYDVDDEESGYDSDRPALYNNQKDNEPYPYENYQSQLETVDSEDDKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9J5</accession>
    <name>A0A5N6U9J5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1688-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_146393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9J5"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47584" checksum="91CB590D02C8E9FB" modified="2020-04-22" version="1">MDPEVKYILSLQAVRERAHRVLRLAEEGRLRHFDYHADGFEGAVKYVANIIKRDFGPDRYGSIPPHGRWQHFNVGDADRIKDLQDRWTASGYDKTEQARGLVDLFFVSVLLDAGAGDKWRFTEPGSNAAFGRSEGIAVATLHMFNDGEFASGAERKDIVTGTALRDFSEAKLLRGFQITDNNPFVGVPARVELIKSLGRSLLNLPDIFRESGRPGNLVDYLVARADESNRLDFQVLWDTLQSVLLPIWPSSRTQVDGRPVGDAWPLTVLADEAARTGTQSKCSHIQPFHKLTQWLAYSLMVPLGRLLGVSWKNAEIATGLPEYRNGGLFVDLGVLTLKEESQKRGLSNSGSNLPAFDATADEIVEWRALTVALLDKLHGALQETELGKENLSLAQVLESGSWKAGRELAAAHRPETRSSPILILGDGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9Q5</accession>
    <name>A0A5N6U9Q5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_135094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9Q5"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="295" mass="32349" checksum="12784B4C15DF215A" modified="2020-04-22" version="1">MSPVSDALAVKPAFEDRNDIFTNVNPLWRPDGMKAVFGGALMSQALNAALQTVGPSWSVQSMHCQFTSAANIDSPVFYHVHGMDSKKTFLVCNVSARQQERLIITATLRFTRSSYSVGTGLQHATPKPKIYLGPDPKHYRSGEGTAKGLCEFKTAPDPSCDPQSPAGNRFRRLVRLRSRIPHPAGTRDHVVALAAVTDTYCLGTPGRAHGLSLLRPSEASGEAEAQWKVRQMGTLSHSIHFLNPQAVCLNEWMLEETWCPWAGDERGLVMLHLWSQDGVLLAVCTQEVCDPLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCK6</accession>
    <name>A0A5N6TCK6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_119311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="ML742874">
        <property type="protein sequence ID" value="KAE8144118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCK6"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="249" mass="26499" checksum="23AD5E1A76EE414C" modified="2020-04-22" version="1">MSAATIPPPAAEQDYKETLLPLLMKNNVLSFGSFVLKSGRESPYFFTSSLLHTAPLLRATSAAYASVLSAPPFVTTAADGTTTPNFDIIFGPAYKGIPVCASVLNELAVRDSLSASSQGTWDNVSYSFNRKEAKDHGEGGNIVGAPLKGKRVVIVDDVITAGTALREAVSIIQNQGGIVTGVVVLLDREERVSDDEPKSAIGVAQRNLGGNIPIRAVIGLHDLIEKLGDKIGESEVQRLKDYRARYGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCY7</accession>
    <name>A0A5N6TCY7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742624">
        <property type="protein sequence ID" value="KAE8144244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCY7"/>
    <dbReference type="OrthoDB" id="4501510at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="18067" checksum="80093B7EF5B5B57E" modified="2020-04-22" version="1">MPYWATIRTRNTLIPHDGDKRYQKKYTLFLQECLRILESGCTTAITIEEAKHFPDASDDESDETDFYETVTSAYETGSETDTDETSDETDSESAYGSNSEDVRKRSNRYTTDLPWEKNGEPGVEYALKQLREKALADLRNLDERCGGRIYTKPALGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD15</accession>
    <name>A0A5N6TD15_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_104771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="ML742635">
        <property type="protein sequence ID" value="KAE8144233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000047">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="346"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="587"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="956"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1409" mass="157723" checksum="2D037B393608E8DE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDK2</accession>
    <name>A0A5N6TDK2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_166940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742538">
        <property type="protein sequence ID" value="KAE8144402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDK2"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="569" mass="63527" checksum="34DC0C15CF0D0AAB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDK7</accession>
    <name>A0A5N6TDK7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CrcB-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_166785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742514">
        <property type="protein sequence ID" value="KAE8144464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDK7"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="436" mass="46839" checksum="050539C5543E5E21" modified="2020-04-22" version="1">MQSTDLGELDIHLSETQAPPPTAGQASQRLNLPSAELPPTTDKLPYSPVEPPPARKEHVASPLSQHATQLFTLSYLVFFSIFGTLARLGLQALTEYPGAPVVTGVLWANVGGSLLMGFLLEDKNLFREEWGDVDNKLRRTNNGTPGDHSPQDPSEAAKRHKTIKKTIPLYIGLTTGFCGCFTSFSSFIRDTFLALSNDLSDPSAASTVSRNGGYSFMALVAVIITTVTLSLGALMLGAHLALALDSLTPVVPFRFTRRFLDPIFVLLGWGCWLGAILLSIWPPDRHDRSAEVWRGRAVFAVVFAPIGCLFRYYVSMVLNSRLPTFPLGTFAANIVGTIILAMCFDLQHVDGIGASSSTAAASSSVLTSCQVLAGVMDGFCGSATTISTWVAELNGLSRRRHAYTYGIVSVGVALGFFVVITGSLRWTLGFVGPVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDN8</accession>
    <name>A0A5N6TDN8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_134840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742627">
        <property type="protein sequence ID" value="KAE8144241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1247"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1294"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1446"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="132"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="836"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1479" mass="166308" checksum="508041803CBBEEB5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEQ5</accession>
    <name>A0A5N6TEQ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BDV25DRAFT_134370</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742438">
        <property type="protein sequence ID" value="KAE8144776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742391">
        <property type="protein sequence ID" value="KAE8145069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG27"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="77" mass="9126" checksum="067B73E4BE53BDCE" modified="2020-04-22" version="1">MGSVMMYDHFPQFGLLSLILLCISLINRLLSWILTLSRPMVSTLLRLSKHQLTIKNRHRRCRYNEAEGQWVLYCRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGV3</accession>
    <name>A0A5N6TGV3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_72786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="ML742356">
        <property type="protein sequence ID" value="KAE8145349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1442"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1667" mass="184808" checksum="46FA6E5F88B097F3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGW9</accession>
    <name>A0A5N6TGW9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_164357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="ML742332">
        <property type="protein sequence ID" value="KAE8145576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGW9"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="442" mass="50626" checksum="2D910B205FCB9516" modified="2020-04-22" version="1">MALPRPYIPLRRSFYRFLSPTARTSTRLSRSFQGAPRSYSSKQEPSESKPFTVWRPYLRLAIGVPFIGALIYSMMTEEVTELDSPSIVELDETLKKQATIGENSPMRLRMEKLIKEHQNKIVEELSRIDGNQFKTDTWARPNGGGGISCVLQDGNVFEKAGVNVSVVYGELPRAAIEKMRADHKSFVGTDVDSLEFFAAGLSLVLHPHNPMAPTVHLNYRYFETSDPKDPINGDKNWWFGGGTDLTPCYLFHEDAKHFHQTIKDACDRHDATYYPRFKAWCDKYFYLPHRREARGVGGIFFDDLDASFLESSATSSQNPQETLFSFVSDGLASFLPSYVPIIERRKDMPYTPAQKEWQQLRRGRYVEFNLVYDRGTSFGLRTPNARIESILMSLPRTASWAYMDPVSGTRTEASIEDEENLSDDKQPEKEIMDVLRHPRQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGY5</accession>
    <name>A0A5N6TGY5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_144595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742339">
        <property type="protein sequence ID" value="KAE8145510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGY5"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="475" mass="52267" checksum="C46A684D2AACCA06" modified="2020-04-22" version="1">MADYLYDILTPHLASNNASHIPLSPEQNTTTAQYLNRLPTLSLQALQETEQQSLAQSSHSTLLSLQALSNRSHRTFISSADSLSNLRASISQLTRDAEQLRDVIPKLDEEAVSFSSKYSRAAENAALEKRKKVMQLARNVDRLSDILELPTLLSTAVSSAAASSGAGGSSSTTYSAALDVYAHIKRLQTLYPDSPLVKDVASQAEDAMKDMTTNLITGLRAQNLRLAAAMRTVGWLRRVAPELENLQSDGGTGTGESALGALFLTCRLANLVSTLEALDPLRELADQESQRRLQRSEKKDSAYGWSDGHQTEKFLKRYIEIFREQSFAIVSLYKNIFTPEQSESDIAVAGLRGIDARVKSTVSRPVYNDPLQALPSALATFPMHLIQLLTETLRTYLPNVRDKSSRESLLTQILYCAASLGRLGGDFGMILTELSDTDEDDEMAYEWEEVTKKHRALAGRLEQLTGGHPTTLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THS7</accession>
    <name>A0A5N6THS7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial ribosomal protein L27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742305">
        <property type="protein sequence ID" value="KAE8145877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THS7"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14769" checksum="51EC1FA3D20CB5F4" modified="2020-04-22" version="1">MFKPSQPLMARLRLTTKQVNGGYYKGNRTGSMGYFAKNGSYVIDWKKVRTYVVPEHLDEFKLTPFVTRRMAPTKSKYTRDFEKNGRVITVERAFGAKDYLDLWASDNGQEVLEQERLEQEAASSSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THX1</accession>
    <name>A0A5N6THX1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_59160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THX1"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="290" mass="31522" checksum="7B97D3368782C912" modified="2020-04-22" version="1">MSDVAALEAEVKEFKLQLETIQSSLQVDPDNTELQSLKAELEELINLTETSIAELKPAAPPAPKPAPPKEKGFRDSYSTSQPGYRKPTVENTDEPAPPASFTVNEHVLARWVSGDNSFYPARITSITGSSSNPVYLVSFKSYGTVESLTSKDLRPISSNDSRKRKADGSSGNSATQSPAPQLPNSSVISAAADINPALANQARKEPSKANDGPVRPAKAPRKVKANRELEEGKMKWKDFASKGKLGRKESMFRTGDGVNARVGFTGSGQQMRKDPSRTRHVYQQAEEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THX2</accession>
    <name>A0A5N6THX2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_58967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742298">
        <property type="protein sequence ID" value="KAE8145968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THX2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="642" mass="72052" checksum="F740A5713A34B5BC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY2</accession>
    <name>A0A5N6THY2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_144197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742300">
        <property type="protein sequence ID" value="KAE8145943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THY2"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="878"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="919" mass="100937" checksum="EB066775FDA4FD3D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJC2</accession>
    <name>A0A5N6TJC2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_132943</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="ML742263">
        <property type="protein sequence ID" value="KAE8146427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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            <begin position="22"/>
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            <begin position="318"/>
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            <begin position="30"/>
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            <begin position="1205"/>
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            <begin position="1330"/>
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            <begin position="1519"/>
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            <begin position="40"/>
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            <begin position="1205"/>
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            <begin position="1242"/>
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            <begin position="1334"/>
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            <dbReference type="EMBL" id="KAE8146427.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1641" mass="185643" checksum="88834D1161A14CD9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TJN7_ASPAV</name>
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        <submittedName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
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        </source>
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</entry>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJS4</accession>
    <name>A0A5N6TJS4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">BDV25DRAFT_162651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Spp1/CFP1"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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            <begin position="494"/>
            <end position="545"/>
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="336"/>
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    </feature>
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            <begin position="353"/>
            <end position="489"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="637"/>
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        <source>
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            <dbReference type="EMBL" id="KAE8146359.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="850" mass="94523" checksum="A569708E79296786" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJW3</accession>
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            <fullName evidence="7">MADS-box domain-containing protein</fullName>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
        </source>
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    </evidence>
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    </evidence>
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</entry>
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        </lineage>
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Barry K."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Magnuson J.K."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="39984" checksum="EF6C5CA14E75BF70" modified="2020-04-22" version="1">MLLQSPCVLEGWSTDLFQHLRYEGLSVVCESLSSSPSVYSTAAKTTYGVERIGSHLSRSLWERALESIPSHTKDPGNDVNESIIMAFIQVHAFVKDPIDGLRRDFDRQRQTFLELWTDFKRQYSTRRPLNESTRQTIFAQLAQESSFLAIPKLTKLAYLHYSDHQQLPYAYASIKKLRRAEFSTPIRVLEIVRELFLMTMDQGFSSMAPITVTYRPGADRQGRRFKVVLDGNNRLVAISLLQFLSYQPLSTERGALQNFFQKLGYDEKWLAELDEVLNKLRQEKSLLQLVQDHSNALEYFRSVTRAPILIVQEDEFHTVYGCSSCLAFEAKRQSHGRPKGFYPLPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKL1</accession>
    <name>A0A5N6TKL1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_44153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742239">
        <property type="protein sequence ID" value="KAE8146855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKL1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="177" mass="19348" checksum="07734332A2A5B1F1" modified="2020-04-22" version="1">MAPIAVEPSPATASVLPTSIETPPTHPDRLRVDRGTKAFSSGAVSLISLPAGSVFAKITTATPAKKAYTSVQTGANSHIELNSDLVYCNHSCQPTLNFDMGKMEVRVVDDRDLKAGDALTFFYPSSEWEMDQTFQCNCGTETCKGWIDGAKKMDRNSLEGYWLNEHIEGLLKERESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKQ2</accession>
    <name>A0A5N6TKQ2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_43444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742235">
        <property type="protein sequence ID" value="KAE8146923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKQ2"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8146923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="651" mass="71202" checksum="0668BF8F41B30EBB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKR8</accession>
    <name>A0A5N6TKR8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_169665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742246">
        <property type="protein sequence ID" value="KAE8146709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKR8"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="380" mass="42337" checksum="39E10AA284EB40BB" modified="2020-04-22" version="1">MSSHHNNTRTDPRPKPISTVNYGPELLATAWAMTAVSIAIVALRLVGNYKFHTLHISDIVTLLLFIAATISNVAVHHGYGQTAGSLDHHDEKEAMKYSTTSQALIVLAATAGRLTFNFYLIELLATRKRHRLILWALVPLQVIVNVVSVFLLVFRCSVNIGQLFSPGEEANCMGLDVQIDYGYFQGAFNSASDLLLAAWPIFLFWKFNWNVRVKLVLISLLSLGIFAMAASLVKTVEYPTIMKSIDPRTNRLTLLRWMFIEAGVVLITASIPCVRPILIHWVKKAIRKAHSAHQRLHATHSRMLSSAGQLTESLKSRWMVRTAKPEMEDGDFEGKILANLTTHIFAGDREFLDKHCSGIMKQVEVTVVADEIPLTENGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL59</accession>
    <name>A0A5N6TL59_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_143076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742226">
        <property type="protein sequence ID" value="KAE8147082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL59"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16628">
        <property type="entry name" value="Mac_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="690" mass="75801" checksum="765621081EEF0B3F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL60</accession>
    <name>A0A5N6TL60_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_40756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742227">
        <property type="protein sequence ID" value="KAE8147078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL60"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="658" mass="74673" checksum="D9F5C87891D40FAC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLJ1</accession>
    <name>A0A5N6TLJ1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_160842</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="ML742219">
        <property type="protein sequence ID" value="KAE8147213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLJ1"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="20">
        <location>
            <begin position="42"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="21">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8147213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="47662" checksum="544EBB234DAA3494" modified="2020-04-22" version="1">MSNSVPNLDAVGIKAEPGLTDQFRREVATLLGRNNLNFPGAQPVSFSKRHLLELQNDDYYVCEKTDGIRCLMYFAHGDAESGCPEIHYLIDRKNEYRYVPNLHFPLPGDDSFQSFHVDTLVDGELVNDTYEDGTQQLKYLVFDCLVLDGQSLMHRTLDKRLAYFKDKVLKPYNALYQRFPEEKQHRVFAVEDKSIQFSYGIEMMFREIIPKVKKIHGNDGLIFTCRSTPYRIGTDEHIIKWKPPSENTVDFRLRLEFPLLEPDTDDEAEGIFEPYADYDAMPIFHLFVTLNANEYNHFGEMFVTPSEWEDLKALNIPLDDTIVECAKDEQQRWRYHRLRDDKADANHITTVDKVLESIDDRVTEEDLIRAAPAIKTSWKKRQAQMAADERRARPGPPPVNGNGVKRKFEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLJ9</accession>
    <name>A0A5N6TLJ9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Probable glucan endo-1,6-beta-glucosidase B</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_169250</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="ML742218">
        <property type="protein sequence ID" value="KAE8147222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLJ9"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024941324" description="Probable glucan endo-1,6-beta-glucosidase B" evidence="19">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="20">
        <location>
            <begin position="87"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8147222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="46547" checksum="A5D0E3E36BDC6AA0" modified="2020-04-22" version="1">MILKQLTTFGALITTAVAWLPWTDKGVVSRNGTNLFASSGGKIRGVNLGSQFVFEPWIAMQAWSAIGCKDEKSEYDCVAKLGQDAANKAFARHWKSWITRNDIDEIRRYGLNTIRIPVGYWMMEELVRPGTEFFPQGGIDYLARICEWASEAGLYIIIDLHGAPGAQVPKNAFTGQYAEKPWFYVDHEYKRALRFLDWMTTIVHTNESFRNVGMLEVVNEPVQNADETTSLRSSYYPDAFRTIRGVERKLKVHRKDYLHIQMMDKLWGSGDPHEHLTDDYYAAYDNHRYIKWDANVRVSKDNYISTSCRDRVGSNWPLLVGEWSLGVPEDIQETPDWKPFSNKDFYKKWFAAQVMAYEKQQGWVFWTWKTQLGEFRWSYRDGVAAGVIPTDLNSVFEEDVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM04</accession>
    <name>A0A5N6TM04_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_35753</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ML742214">
        <property type="protein sequence ID" value="KAE8147310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM04"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000061">
        <property type="entry name" value="Metalloreductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="756" mass="86101" checksum="4ED53CD39F028736" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM55</accession>
    <name>A0A5N6TM55_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_33729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742209">
        <property type="protein sequence ID" value="KAE8147408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM55"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000363">
        <property type="entry name" value="Zinc finger protein 239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="579" mass="63859" checksum="80215D56C9014534" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM93</accession>
    <name>A0A5N6TM93_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_160246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742205">
        <property type="protein sequence ID" value="KAE8147482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM93"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="6">
        <location>
            <begin position="517"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="586" mass="65926" checksum="007EEA1C5C19657B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMU0</accession>
    <name>A0A5N6TMU0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_142560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742198">
        <property type="protein sequence ID" value="KAE8147625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMU0"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="487" mass="53679" checksum="244ADF4F05D31570" modified="2020-04-22" version="1">MTNFQHPFQCIQFLEKQETQENGSQKLLVASAGPKLYSYNAETGERLAVWPQDVDANKTHDSAAETDQAPPEKKRKVSPTAEEPVNDVKSGAKAPAWSNIPIVVATANSEHVVAMTAEDKTIRVFQLQADGTFDQLSERCMPKRPCSIALADDDRTIVCGDKFGDVYSLPLIPGNEPYVAPKLVSRPKVPAATPLTVHSKRNLESLEQQLRHQQQKKATEEKTGINFEHQLLLGHVSLLTDVAFVSLPSDVSPTGKRSYILTADRDEHIRVSRYPQAHIIENYCLGHNSFINKLCIPEWAPEHLISGGGDNYLLVWKWAEGQIVQKVSLVDEGSEDTQVAVRGLWAVSSENSKVILVALDGTSQLLCFTHEVDGSLKAQEPIETTGNVLDVTSTGKDNKIFVTVDSIREKNSTQEWRASPSTLIESFRVKSEVEALDWEAVTESPVTNINSSGTSDIVADADAKQRKDLNLSVYGLGNLRKKLGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMW7</accession>
    <name>A0A5N6TMW7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_159898</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="ML742197">
        <property type="protein sequence ID" value="KAE8147645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMW7"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8147645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="343" mass="39146" checksum="CC5844501B95B645" modified="2020-04-22" version="1">MTIHWAPLNIGLERRLQTFVVLCHTLTIAIFLTAFFFGCAIPLTWPILLPYLIYISLFSRAATSGTLNGRSDYLRSLRIWSLYASYFPARLHRSEPLLPTRKYIFGYHPHGIISHGAFAAFATEALGFSKKFPGITNTLLTLDSNFRIPFYREYALAMGVASVSRESCENLLTKGGADGEGMGRAVTIVIGGARESLDALPHTLRLVLKRRKGFIKLAIRTGADLVPVLAFGENDLYEQVRSDRHPIIHKIQMLIKHNMGFTIPLFHARGVFNYDVGLMPYRRPLNIVVGCPIQVIRQEDRDRIDDEYINHLHSKYVQELRRLWEQWKDIYAKDRVSELEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMZ6</accession>
    <name>A0A5N6TMZ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742193">
        <property type="protein sequence ID" value="KAE8147736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMZ6"/>
    <dbReference type="OrthoDB" id="4488533at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="144" mass="15915" checksum="5629569AAC16E819" modified="2020-04-22" version="1">MRHRELSHSATILLADIPIAVLQVLFNRKSYADSTVQAKNPQIHKTEALMLYTKMNLKYLPLAISLLATTISAESYLVMACNTNTIACRTAGIPCDNSYDASCPVRDDMRSEFAEVCRRSNGYVEIRVESGLTLQQAKNAAGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN12</accession>
    <name>A0A5N6TN12_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_159699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN12"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="82" mass="9075" checksum="F9A75DCCF7BD9854" modified="2020-04-22" version="1">MPLNWPANDKVILEGSSQGYHHNLLLFLHNPIFQSQPGTKISIMDRTGAGQSSTVTVTLSSSYALGEKLNLNRRSFFQGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN53</accession>
    <name>A0A5N6TN53_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_160152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742202">
        <property type="protein sequence ID" value="KAE8147539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN53"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
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            <begin position="238"/>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">IBT 18842</strain>
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        </source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Riley R."/>
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                <person name="Magnuson J.K."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="167"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
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            <end position="231"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="842"/>
        </location>
    </feature>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Magnuson J.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
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    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="327"/>
        </location>
    </feature>
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            <begin position="328"/>
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        </location>
    </feature>
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        <location>
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            <end position="428"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8148553.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="99416" checksum="0A490C73AAC7CC5A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="245" mass="27852" checksum="E895F064774CC6AC" modified="2020-04-22" version="1">MTPFTRVRSIKAKFTKRRPPPNLKIWTLPAPILLHIISHLDLPDFQALRLTTRALNTRIKTLEPAIAHTYYVVRRSELSFIAELFPPPPPLYGADDRPEYSLAYLADLTTCWRTCLRLSFYLAEHVVLRGTHHVMTLLCDAVRALMAPCITYSSETWLAALLTQSTLEKVVELFAAAARDGNGRDQRMEFLWSLREVVGCCGEVKLERVWFCAARREICRRGAIPHFSGLSSTLGTGDVRCEFCE</sequence>
</entry>
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    <accession>A0A5N6TRG3</accession>
    <name>A0A5N6TRG3_ASPAV</name>
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            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
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        <name evidence="10" type="ORF">BDV25DRAFT_8638</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNR_small"/>
    </dbReference>
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        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="405" mass="45759" checksum="143075332CA98EC6" modified="2020-04-22" version="1">MSVQVTPSKQTASSLEHLKMSDSPVKKLSFDAAGKENAPSSTPVVDAPATKAVAEKPAEAPKVAPGIKEMEANEPLLQENPHRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLSKDLHDWHNRLNDDERYFISHVLAFFAASDGIVNENLVERFSGEVQIPEARCFYGFQIMIENIHSETYSLLIDTYIKEPKQRTYLFDAIDNIPCIAKKAEWAIRWIQDRESTFGQRLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFSHLNNRPDPQVVEDIIVEAVSIEKEFLTDALPVALLGMNSNLMCQYIEFVADRLLVSLGNKKYFQATNPFDFMDNISLAGKTNFFEKRVGDYQKAGVMASTKKDAVQEQSSSNDGGLNFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRV5</accession>
    <name>A0A5N6TRV5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_156970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742135">
        <property type="protein sequence ID" value="KAE8149086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRV5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="291" mass="33274" checksum="994CA877EF8FB5D8" modified="2020-04-22" version="1">MTQSPSSYVMTKPDEQGEENRLDLQHEIWLLALENRLHTTIFNQSPKAILDIGCGTATWALSMAQIHPEAIITATDLHHPPRLNFTTISSTPNIRFLQFNANDLVWPIPEKENTTFDFIHGRMITSGIHDWPRFLTHCWSLLTPGIGRLEFLDVSHPFRAENPAADGETLSPFIRFGHAIERVWAAKGIDYRATEKHAHRLAELGFEDIVTEEVKWPLGPWVDTTEREMKLGLLNMNNFGQFIRTAGVAILLSNSDNSDDGEQRVDAQRLVDDAVRDLEERWNTNRYYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRZ0</accession>
    <name>A0A5N6TRZ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742136">
        <property type="protein sequence ID" value="KAE8149064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRZ0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="363" mass="39569" checksum="C3E68B7265475BD6" modified="2020-04-22" version="1">MSGPELEISDGETLVSRKMDSKPRSTKLTYNDYTVGWVCALPKEQTAATVMLDRRHPDLPKRRGDHNIYTCGSIGRHNIVIACLPKGKHGNNSIAALSTRMIATFPFIGVCLIVGIGSGIPPNVQLGDVVISTPGNGYAGVVQWDMGKAEPDGKFKPITALNSPPDVLLIAVAKLETHNEIYGSSTRHCLDDIGRRYPNLAPRYTQPGPPGDSSPTSYILYHSQNKWVTMYLVLLEKIVGLLGYTLGWLVFASMRILEKQSPNTTHNALGQFQRKPEGTQVHYGLIASGNQIIENVKTRDRLNKAFGGNVLCIEMGAAGLTSHFPCLVIRGICDYADSSIDRGWQEYAAATAAATAKELLEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TST0</accession>
    <name>A0A5N6TST0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_2468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TST0"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8149418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="18811" checksum="8018894D0B77C28F" modified="2020-04-22" version="1">MASIARQSSLLRQTCLSAFRSPFAAKNGAGVSQVVAFHASSKKQILPPLPQSIQGTMNDPAPIPTPHPSEGSYHWTFERVISAGLVPLTIAPFAAGSLNPVMDAVLCSFIVLHSHIGFQAAIIDYFPGRRVPKTRTFCNWLLRGFTLTTAIGLYEFETNDVGVTEALKRVWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSU3</accession>
    <name>A0A5N6TSU3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ATG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_141028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSU3"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000861">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000065">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="89"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="238"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="715"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="755"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8149199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113011" checksum="7AFED2D3627F282E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSW8</accession>
    <name>A0A5N6TSW8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_2099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSW8"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="136" mass="15238" checksum="EADE17B79C62935A" modified="2020-04-22" version="1">MTDNRVPINYQTPAFPSLYNPFPKPNAAVYYLYYTRDIWRFTLYWTLIFYIASHLAVAAWALAMQGRSWRICLAIPLVYSVIAGLEALLAGSIIGVVLGAVYEAGNFRMSTWIPIIWGGINVLVLILSSFPMQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT76</accession>
    <name>A0A5N6TT76_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_156070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT76"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="244" mass="25616" checksum="0EFA0322101A0454" modified="2020-04-22" version="1">METVYPMETLRTAPPAGYNKQMGHASLLVDRPARLVGQLKPTDLASSVNSVPRVGFSNRTEFAKSPFPTAPRDGSAKPMVPACPPVLTARLAGPLNPTDHVCPLMEKAALRAGRLKATDLASPPGLIVPRDGHNYPTEFASNYHLTAPRAGSVRPMIPACPPVLRAPRAGPNRPTVPAYLPVVKTVLPAGSANPIVHVNPPGAQIALPTGSARQMVPASLPVVVRTAHLAGCAKLTVHANPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTC3</accession>
    <name>A0A5N6TTC3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_124268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742117">
        <property type="protein sequence ID" value="KAE8149618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTC3"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58809" checksum="E3D4DF59CCE8BBB4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTE0</accession>
    <name>A0A5N6TTE0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_155954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="ML742117">
        <property type="protein sequence ID" value="KAE8149623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTE0"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="365" mass="38379" checksum="420AAEC8902C96F8" modified="2020-04-22" version="1">MSVLNGTPRTPWIETPLLESAALSKAAGCQVFLKLELLQPSGSFKTRGIGNLIRNAILNPTNQGKELHFYSSSGGNAGLAAIVAARDLGFPCTVIVPHSTKPMMIDKLRAVGATDVIQHGSSWFEADTYLRKNFIETNQGDSEVKTRNIYVPPFDHPDVVEGAATMIPEIAAQLPPRDTTSCSDFPADVVVCSVGGGGLFNGVVKGLGDYLRSHSASDTNGQPRSNVHVLATETEGAHALAHSLRSGSLQSLSAITSLATSLGALCVAPETLKNAQSPPAGVNVVNVVGSDAEAAQGIICLADELRLQVELACGISVEAAVGSKLREAVRELTPDSRVVVIVCGGSNITAEMIAEYRQKLQQGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTX0</accession>
    <name>A0A5N6TTX0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_155680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTX0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="77" mass="8674" checksum="22903B17F739510B" modified="2020-04-22" version="1">MPVRSSLDGFTELEARVHPINAINESDFPDLPDPPQVEGVSHWNPKQKKKSIGRRPEGANIQSDEVSDDGHRQESWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU05</accession>
    <name>A0A5N6TU05_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_155472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU05"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45007" checksum="E4551B8E9388B067" modified="2020-04-22" version="1">MSINDMLSVDISLRKGEYSSEESYLVSHLTGDKIEGLVTVRPHCDIRIDGLEVFFIGEERTTVQMGKVHRQFQNIKYDVDESGFPPMNKFKSKQRYRFKFDFEVRDHLPPEACTHAVASPVVRQAHLRPPPSFGDPTVSGLGGKLRDDYAPPTCRIVYTIQVNVLRNIPISDKKSVLMTRTLKLRVKPAIDATPPLDLMSSPNDYCLEQDHAVLDSRSKAPMGQLTVILDPPKSFCLPLRDPHSLVSSTVNMALRYETSEAHPELPQLQSFRGQLVATTFYTVTHHDDLPTKKKDFFNRPKNYSDTQFPPFSYSMASLDWVQVSHTMYETALLVPLTLPRLNFIPTFHTCLVSRIYALELRITVPGAAPFTLKAPVHIYAERDPSALPSYIAAVGFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU10</accession>
    <name>A0A5N6TU10_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742118">
        <property type="protein sequence ID" value="KAE8149599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU10"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025026919" description="BTB domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33189" checksum="8ACD55D1CDB5D99A" modified="2020-04-22" version="1">MTSTNAVFLLQMVSQILAHPQRVPFSMDYNPLSQPPEQKTATNSNQRDVPRHAQDTFFKEQPFPFAPSLTLYPKYDDQFTIVCNGRYFQACKSNICSQSEFFATASAFGLLEPLKKVEFPDHPLVVKMMLAYLCRGDYEFYMHYGFDLKTAQNNRGPPADITDRLHCCELSLHIQVFILADRVQMTSLRDVSRTKFMAALETANFANVIPWAVKEVYELTSDRHQVLRNTIIEYVNRALAEGLYNGGYPSQFPMYMLEESPEFTQTWMKLKFDGWLEQLTGSGSGSSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU49</accession>
    <name>A0A5N6TU49_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_140412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU49"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024870739" evidence="3">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="231" mass="24238" checksum="134F148543F4BAE9" modified="2020-04-22" version="1">MRFFQIASLVAYAASSVALTINSPKNGDKVDFSKPYKIEWNTVDSDPNNFTINLVGSNPRVNKEIAKSVKSSDNSYTIKSLWDIKPANGYQLNFVSADKDNTGILAQSQNFNVTKVADPPKTSKHDLSTISPAPSCTKSSTSTKTSCTKTHSSSRPCIIHSTFTPSPTPSRTPCSPPSSTTPSDSVHKASASSSTSATQTAAAPTDSTAGSAALAIPASGSLMLSLFALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUN9</accession>
    <name>A0A5N6TUN9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_155143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742104">
        <property type="protein sequence ID" value="KAE8150078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUN9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000171">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="704" mass="76816" checksum="3A847DD28A199E8C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUY3</accession>
    <name>A0A5N6TUY3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_154902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUY3"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000231">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="63"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="218"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1123" mass="129695" checksum="554F4FD782705E41" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV51</accession>
    <name>A0A5N6TV51_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_115277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV51"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="270"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="443" mass="50824" checksum="6B4C037A6CB5BBA3" modified="2020-04-22" version="1">MLRSHPARRWHAFRQARAPALRAYSGLHHYQPHNPPPWRPVSALDEWVERDIRPISLRQLTFFGRTLTESRLISSANYVRTELPTRLAHRLRDIQKLPYVVVANPHLSLVYELYYKAFERFRTIPEIKTLDDNDDFCDILRRTLKEHLVVIPRLAMGVLECRDLLPPEILDHFMNTLLRARISRRVIAEQHLALTETFNSPWHFPGSHDRTDLNADFVGEVFLKCNAKEVIERCGKLAQDMTRQASGSDQIPEISVQGHHDATFPYMLSHLEYIIGELLRNSIQAVSEKYTGLSEKPPPIEVLVCEAPQHVILRISDQGGGIPREVLPYLWSFNKGPHSKARLQNLEQVPAMAATMQELTVPRERKRVDKETFRESSLDTLTSRPPNLRLGMGLPMSRVYAEYWAGSLELHSLEGYGVDAFLQISKLGNKNEQVTTRASIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV73</accession>
    <name>A0A5N6TV73_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV73"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="174" mass="19539" checksum="2B2E6F58F5E5E5BA" modified="2020-04-22" version="1">MATSIDLLDHLTSFDQLLPSAKSNTNLPIPEALNQTKAAYDKFLLEIYDHNMNYIDAVFELYGKDFDEAEWDSKFQEASEVYETGQTAATKELATEITRIFLAVGQDKYRYYRIGARAYSPGAGYLGVCDRNRSVVQATLMESMGKEWVPALGFRGQISKGYKYATTRVASSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVT9</accession>
    <name>A0A5N6TVT9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_114495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVT9"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="557" mass="62909" checksum="F385E5C000961E05" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVW0</accession>
    <name>A0A5N6TVW0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_172148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742092">
        <property type="protein sequence ID" value="KAE8150518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVW0"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30700" checksum="93A9D67E82179CA7" modified="2020-04-22" version="1">MAHTDDYVLGRSLSDSVRLDAQHLLWKLHTGHTLHPQIPIADGMKVAEIGTGTGIWIFDLAKDLPRTAQLHGFDISQDQFPSRALWPPNVSLRVLNSLVDPPPSLAGRYDVVHVRMWASNIKDRDFGPLISHVLRLLKPGGYVQWEEADLVHQVVEGARAQQFGEKVPVLFGKVGLDYRWASDIHHRLQKARCTVLRFKRGRFQSFLAQKCTETYLLALAEIFRGIRKSCTDDLLPLLSECEADLQELSALHSNKGVVYNWSPIEVLARKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXK2</accession>
    <name>A0A5N6TXK2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_153273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXK2"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="582" mass="63282" checksum="559DE90AD564E2A3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXQ4</accession>
    <name>A0A5N6TXQ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_153131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXQ4"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="58"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="310" mass="34178" checksum="1624BD5DD7EA79BC" modified="2020-04-22" version="1">MAQNPREQWERLQVMLRQRGGRGGFGMGGFPSGGGRGNLGLMGAMVLLGVGGWAISNSLFNVDGGHRAIKYSRIGGVKKEIYSEGTHIQIPWLETPVIYDVRAKPRNIASLTGTKDLQMVNITCRVLSRPRVDALPQIYRTLGQDFDERVLPSIVNEVLKSVVAQFNASQLITQRENVAKLVRDNLARRAARFNIALDDVSLTHLTFSPEFTAAVEAKQVAQQEAQRAAFLVDKARQEKQAFIVRAQGEARSAELIGDAIKKSKSYIELRKIENARHIASILQENGGKNKLYLDSQGLGLNVNANAEDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXR8</accession>
    <name>A0A5N6TXR8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_100288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
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    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14363" checksum="8B2BC81D54C8C903" modified="2020-04-22" version="1">MRAGCINPSMELTGGTALYKYGAITEVTRGIYSKLKTTVFRKLANGEEFRTEEHVILAGVEEGQEVPRGEGPFLLPGDSGSVIFNENLEMVGLAFAGQMQGKFCLFTEVHDLIQDIKDRTGADEVILHGQR</sequence>
</entry>
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    <accession>A0A5N6TXV1</accession>
    <name>A0A5N6TXV1_ASPAV</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
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            <position position="296"/>
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        </ligandPart>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8150919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="360" mass="40831" checksum="7660C32376CBF0F1" modified="2020-04-22" version="1">MSEWFHFIAYEHIWKMMAQVVTAYVIHSDRLCNPDYAQFCRDFCDQVGKFRDLRGRFPETLWPLVRRFSRCGRTLQSTIASCKSILTPEIRRRIAYAQANQCPKDSHTLVDATIELKIMKGEIGFHTPLANEGEVINGIAGDCLLAVFEAAFPITVYVIGMMNYAISHPDYADTLRNEVLSALSSTGGEWPVEILDRMPRLEAFARETARCDLTSIFTATRRLLKPVYFESIGRTLARNTSVTLPVNCYHQNPDFYPNPGTFEACRFYNSEANTCEPRAATVNSSFLSFGCGAEMCPGRAFGMRQVQLTFAKILISFDFDSYPMKGVKMSNGVSGPAATLNQDIIFQWRRRSFRRSGLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXW8</accession>
    <name>A0A5N6TXW8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_153027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742076">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
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    </feature>
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        <location>
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        <location>
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            <end position="668"/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="87973" checksum="7715112BF3DFFCB6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Isbrandt T."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742070">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="94" mass="10632" checksum="FEED73F56FBDF3E1" modified="2020-04-22" version="1">MLHCYVKVPHLRYHLKRIRSTRLLILSVPIATSYTTVFSRETNRHKPLIKFSFQNTSCNGLPLSLSPAYHLCAPDAQCQVGTFSCGLAQLRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZB8</accession>
    <name>A0A5N6TZB8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_152208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZB8"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8151726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="74" mass="8748" checksum="A331CDEFA075CCF4" modified="2020-04-22" version="1">MAGPSKSLILDPALQKYYEVNANRYKYFKWTPRHAWFSFIYMGVIPGVLGYVAYKTEGKFQFRGKRKEDSLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0A8</accession>
    <name>A0A5N6U0A8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_151689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0A8"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="232"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="432"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="507" mass="56089" checksum="AB3427BB3412CEDD" modified="2020-04-22" version="1">MTENEKSYPPEFTDERGLALASNIIDYQLNHGSLLKHIDLAAPFPEGPTTCSPVGVTVFPTLFPREQFERAHELQPIYNELYCAVAEDEEWIFDTIQPLLPIDPLAAALWEIYTQVKQMGHAQDISAGIFRSDYMIQGPGVDFPVSHTGCNVSLKQVEFNTFSCAGGTHASKAGDMHRYLARTGAYRSDGNVSVSYEALPRNPILPSLAACLGDAHEAYGPKRSDQASEKGVLFVVQPNNFNVADERPIEYALWDLDTPVPACRAEFPSDILDYTTLTESRELLFHPPWLPKTIEVSVVYMRAGYEVHEYDAAGKEARLRLELSAAVKCPSLLGHICTFKKVQCALIASGALERFVSPVEAEMLRSTFMAMYPLDESELGMHARRLATDPVLARDYILKPSLEGGGHNVFGDDIPDFLASTPEEKWAAYILMQRIVPPSAANVLLSPRGLDSGPVVSELGVFGTCLWKRGRVLRNSVAGWSFKTKDEEVNEMSVVKGYGCFDTPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0Q1</accession>
    <name>A0A5N6U0Q1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_74863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0Q1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="345"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="896" mass="100104" checksum="3F3D35272C4472A9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U147</accession>
    <name>A0A5N6U147_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_77992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U147"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="337" mass="38261" checksum="906352D901A3C381" modified="2020-04-22" version="1">MAVQEPPVIDFSPFYGPESPAKDKLVQEIREACETFGFFQIINHGISDDLRDAIIQQSKEFFGLPIETKERYNLDVNGNNRGYERLRSQNFEKRDKGDLEEGFYLGPHLPLDDPYVVQGRFEQTRNTYPVEVKDPGEFRGVMDGYSHALTGLAIGVLQMLARTLGLDEATFDDCRDHPVVILRLLHYPPQEPDASHLERGIGAHTDFGGVTILLQDETGGLQVWNNLSNDWADVTPIPGAFVVNLGNMMTRWTNDRYLSTLHRVINKSGKERYSVPFFFSPNPNKVIECLPTCLDPVQGAKYPPVTVHEWMVGRYADTYGRTNDQSFEEMRKEGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U190</accession>
    <name>A0A5N6U190_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_151212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U190"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="45"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8152365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="418" mass="47248" checksum="E2B77790FD79CF53" modified="2020-04-22" version="1">MYENPPSSETAPQYEYIEDCERLERYCPGGFHPIKLGDRLCDGRYLIVQNLGFGGSSTVWLASDQKQQVLVAIKIKTADSASESQEIDILTQLHGCPWIRQLLDFFIENSPNGAHQCLVMETASCSLTQSKSLASHALLDLPTARTIAFLPMYIGRYTVPNNITDIHCGNIFLRLPADVRQMTDPLQLYQKFGNPIFDAVVRVDRKPLPAGVPTHVVWPARIGIQSDQITPMHLPIMLSDFGSSYYPHKTRRTTAHTLPHLVAPEIFFLDKDKDEEGLSFPSEMWTLACTVFEIIGSGGPFSTLGGGILQDQVSVLGKLPNPWWSQWESRAEFNNEDATIDITTGTPVQDSLEERYDWFVNVARRRSDMEKPGEDEKKAFLHMISMMLQYSPSDRATIQEVVESEWMQKWALPAKNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U226</accession>
    <name>A0A5N6U226_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_137627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U226"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="199" mass="22798" checksum="BCF5CA22AC39A691" modified="2020-04-22" version="1">MTQPTQILTFQRPKSPNTPYTLTLQQPTPIPLYTITPSSKPNLTISRYHNTSHPPTNTETSHRQEPKTGTVTLSPHSSKITLTMHASPAAIKLKRRDFLASGHRFTHPRFGVLEWKETDLFRKRFKLVDANKAVLARFEKWEVSPEKRKVAAFLVYVRVDAEMLDWIVVSGLGVVEYRVVSDREWEEELWGEVGEGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U278</accession>
    <name>A0A5N6U278_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_170072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U278"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="237"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="785" mass="89145" checksum="9ACB49B88B532AF9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2U9</accession>
    <name>A0A5N6U2U9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_150374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2U9"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000041">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="211" mass="22361" checksum="E76D909238410922" modified="2020-04-22" version="1">MSVTLHTTHGDLKVELFCEAVPNTVENFLALCACGAYNNTPFHRLIPGFMIQGGDISLGPAASQSTETTKPMLPFDDIPKGGTSINHPGALDQEIHLPALRHNTRGILSMAARPVKDRTAPGSQGAAGPTINGSQFFITFAAAPHLDGASTVFGKVLNLTAQDEGGDVLSRLEKANAKIDKKGRVVQPKEGEDYDALRINSVTIHANPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U395</accession>
    <name>A0A5N6U395_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_150146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U395"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="130" mass="14551" checksum="52E703487FE95B1B" modified="2020-04-22" version="1">MSMPSGVSITNECFTSFNDLRSKRGASKPKFIIYKISDDATSVVVDEVSTDPDYETFLQKLSSSADDRGNLTPRYAVYDVEYDLGEDGKRCRTVFISWVPSNTPIKLCMLYASTKEQLRHALDVKTVSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3H1</accession>
    <name>A0A5N6U3H1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_42274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3H1"/>
    <dbReference type="OrthoDB" id="4510916at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024824457" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="16641" checksum="14962EEF7E4A2AA0" modified="2020-04-22" version="1">MQISIKSTAILLALLGSSVVHGTNLQQRQDFSSTDLGEATPTESGSVSASESATESASLPFFTGSGTDVPTPTQSGETGIPTSGSASPTGSSSGVSSSSAPTSGSASGTTSSDASTSTSTSTATETTSDSSSSSSGSSTGTSTSASASPSETDSGASALTYGGLLVVPAILGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U483</accession>
    <name>A0A5N6U483_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 like protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_169594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U483"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41509" checksum="D07A1511FD8B3AC7" modified="2020-04-22" version="1">MSATTTASATASPTCLDITPGKNGYLPPESCDVILYYVPSFAAAVLFCVLFGLTTILHGVQAVLYKKTYTWVIIMGGTWELLAFIFRALQTRQQDKDYWATLHTMFFLLAPIWINAFIYMTLGRMIHYFIPAKKLAHISARRYGLLFVLLDIFAFLVQLGGAGLTTDTDASEKTIMLGLHIYMGGIGLQEFFILCFTGLLIKMHLLMVRMESSHELDFEKLKGGFNWRWLFYAIYFSLGMITIRIIFRLAQYAQGTSATNPVLTHEWFEYVFDAAPMFLSLLALNVFHPGRILQGPDADFPKVTRAEKKQLKREKKEMKMRRKAEKKTGVPQSTAYMGAQPGGYSPVDVEDHTGRWDRQERFYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4C3</accession>
    <name>A0A5N6U4C3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_127243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4C3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="479" mass="51844" checksum="5C1662866AAE1EFF" modified="2020-04-22" version="1">MAIEEFSETRLFINGQFRASANGKQFPVHNPATHETVALVHEASEKDVDDAVAAAKAASPSWRRLGPAERGTYLRRFADLIQASHDEIMRIEALATGKPVSQFFEARVAADFFRYFSEAGWTAQGTTSLHTPDHLNLSVKQPYGVVACITPWNLPILLFAYKVAPALAAGNTVVHKSSEKSPLAAAYLATLVEKAGFPPGVLNMISGFGTPTGSALASHMDVRCLSFTGSTSTGQKIQTAAANSNMKHVHLELGGKSPALIFHDADLQAAAQQTAFSLSFLSGQSCMTNSRIYVEESVADEFLALFKKAFASSRTGNPLDPATTHGPQIDEDQCRRIKSYIDIGRQDGTLSMGGDAGPGLFVQRTIFEGVPGDSRLMQEEVFGPVVVVTRFSNEAEVIEQANRCEFGLYASVFTRDIDRAMRVSTALEAGTVAINCTSPTVAMDMPFGGWKMSGVGREGYLHSMENYLETKTILMRVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4S4</accession>
    <name>A0A5N6U4S4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_149100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4S4"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="765" mass="85024" checksum="D12B43F548039DAD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4V3</accession>
    <name>A0A5N6U4V3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysozyme-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_136605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4V3"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="3" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024820696" evidence="4">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="269" mass="29212" checksum="59253CA82857B6C3" modified="2020-04-22" version="1">MKFSLATISILALSVTALPSEVIRRGVSDSAVELIGELEGFRSNYYYINGHKTIGYGHDCNEKQDCGSISAPISKSEGAKLLKKDLAGFEKCVCQLDNAKDLNANQYGALVSFAYNSGCGGVQSWWHGAMEKKNFDGICEALPTTNTLNGLLTNRRKKETTGGKEYNTYHDAAEDMGIWNATDPLNRTDMDASNDHRLDGMLDVDNFNEAAPEVSNYVYGTGTGASDEDGDLDRGRTLFDKNPGAYSGMTVYPTEGSDPVCESTFDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U542</accession>
    <name>A0A5N6U542_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="10 12">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FDC1</name>
        <name evidence="16" type="ORF">BDV25DRAFT_18225</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="12">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="10 12"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U542"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1670.10:FF:000004">
        <property type="entry name" value="Ferulic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
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        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 12 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="14">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="13">
        <location>
            <begin position="119"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="15">
        <location>
            <begin position="325"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="170"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
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        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
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    </feature>
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        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051594"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="503" mass="55713" checksum="EA55922D6419B10E" modified="2020-04-22" version="1">MAVTSDVDHSFRAFVEALKADDDLVEINSEIDPHLEVAAITRLVCETDDKAPLFNNLKGMGKNGLFRILGAPASLRKSKHDRYGRLARHLALPPTASMRQILDKMLSASTLPPLDPRIVETGPVKEHSLEGDEIDLTALPVPMVHQADGGKYIQTYGMYIVQSPDGQWTNWSIARAMVKDKNHLVGLVIEPQHLWQIHQMWKKEGKDVPWALCFGVPPAAIMASSMPIPDGVTEAGYVGAMTGRALELVKCDTNHLHVPANSEIVLEGTLSITETADEGPFGEMHGYVFPGDSHQCPVYTVNKITYRSNPILPLSSCGRLTDETHTMIGSLAAAEIRKICQQAGLPITDAFAPFESQVTWVALKVDTAKLRELRWTAKDFQKKVGDVVFNHKAGYTIHRLVLVGKDIDPYEGKDVMWAFATRCRPNADETFFEDVRGFPLIPYMGHGTGPRTQGGKVVSDALMPTEYTTGADWEAADFEHSYPEEVKSRVRANWEALGFRKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U553</accession>
    <name>A0A5N6U553_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_136647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U553"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024862138" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="8568" checksum="E7B512370B520FE5" modified="2020-04-22" version="1">MYFKSIIALLAVTTAASCAPSGGDDSQCTTDQANRCCTGLTNGILNIDILPTLCLPLLGSCNNQVACCETNGIGLLNCLTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U555</accession>
    <name>A0A5N6U555_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_127205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U555"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024786854" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="172"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113105" checksum="CA6198C474F05D5E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Q7</accession>
    <name>A0A5N6U6Q7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_126582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Q7"/>
    <dbReference type="OrthoDB" id="4497058at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="304" mass="34238" checksum="004D47EFD4624D1B" modified="2020-04-22" version="1">MSVTIHSQIIDYDSLIPRIVDDESEGDETSSLGFKHSDIADENGTHHWPEDDCEFELSFTYLYSHGADLEAYEGIEGNNLTDTGVSHVLVSSETITLPRKSWKIPGREQHRYFINSQCTVTRLLIETIYLNLEDVKKKDLNLQFITTPRDFRYTIGGTRYASRLEGAAIVGPRAKYMPVISFTGVLVCGKSLNGFPVETFSAMLGQLAQNLRNLSAAFQDQDVFVVGFHGSYLHIARGLFSKDLITRVLAQERLAHEPVGLELTRGYNLCFKKDWLEATQALSRLLRYLLSGKSNVDSIQKFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U702</accession>
    <name>A0A5N6U702_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U702"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="97" mass="11366" checksum="8CD00BAC86E51F50" modified="2020-04-22" version="1">MPPDQLQVILINSKLRPVLDVDILRIEVFKLRLVDFGEDRLVVRPGIFVIIIIVIVNGRRGLGCWFFVFVFAFFFGGDSTRRVCRFRTRRHCLSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U711</accession>
    <name>A0A5N6U711_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U711"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="371" mass="42555" checksum="C89B21E8FF900408" modified="2020-04-22" version="1">MPEEARRLPPADGASSSTLRHYVHVPETKHELDWADLVTLDLSQFDQPGGKEKLAAQLKDAVHHIGFFYITNFGLTQDQIDRQFAIGQELFELSETEKLRHRADLEAGNYNGYRPLGAIEILPGLRDNIELYNVFKFIPRYERSHPDVIRRHYAEIEHFHRFIYSSIVTKLFKLIALILELPEDYLVDGHPYDGPSDCHLRYMIYRARSAEENARHQNLWSRGHTDFGSLTLLFRQPVAALQVKTPEGAWKYVRPYPGSITVNIADALQFWTNGYLKSSVHRVIAPPEDQAHIDRLGVLYFVRPGDGLDLKTVDSPLLRRLGLKKDEGEGEAEVTAGEWVRARVRRNWDKPPKANDENLELGGVKTTVFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U773</accession>
    <name>A0A5N6U773_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_148380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U773"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024887772" evidence="8">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="148"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="542" mass="59674" checksum="6CA5F8F752DA74F3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7E0</accession>
    <name>A0A5N6U7E0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD binding domain of 6-phosphogluconate dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_126541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7E0"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="167"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="305"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="431" mass="45607" checksum="A8FCC36D5997F20B" modified="2020-04-22" version="1">MSKPAIGFVGLGAMGFGMATHLVHEGYSVHGFDMFPASLQRFKEAGGIPATSLKESAEGKSFYICMVASAPQVQSVLFSEEGINATLILCSTVAASYAGSVATELQIRGRGDILFIDSPVSGGAKRAADGTLSIMAGGTDEALQSGCDLLQAMAAESKLYLVPGGIGAGSNMKMVHQVLAAIQILGASEVMGFAAQLGLDAKQTAEKIIESDAWTWMHENRFPRMLEEDWNPGASALTIILKDVGIITTSAREHRFPTPLCSTAEQVYLSAVLQGYGPKDDSSMVRQYYPSPITSVTTPTTEYQATALQLVLDLMLGINLVAAAEAVTFARYLNADLAQFYGLVRDAAGASKVFVTKGLEMIEGRIGEKAPAASQTIDEAISRLETAVQKARDLHCPLHLGNTALNTLLMVRRAGFGNEAATSVVKVFGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7E5</accession>
    <name>A0A5N6U7E5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7E5"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="176" mass="19148" checksum="932B26F1D275D21F" modified="2020-04-22" version="1">MSPPTLPPGYTLHEGYPAVPTYIHLRAAAGLSPHSAVQAEAAMRGSWYGCYIAYHRHNSTGNNEDTDASEEVVAMGRIIGDGGWYFHIADMAVLPDHQRKGLGDAILKDLLARIRLLAPPPEPGVDGGKTQVTYVNLLADGPGRRLYARNGFVDSMPHSMGMVMTFDEPYSPVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7L3</accession>
    <name>A0A5N6U7L3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_147587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7L3"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="84" mass="9686" checksum="AAA950F6173033E9" modified="2020-04-22" version="1">MSCIKDKNEDTSVFPPLKHSPSNKGFSHLACDGVYRAFSSKGEVIDYRQMSPEELQRCWNSLENMLTQRCLRKEGRSLVWMVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7Z0</accession>
    <name>A0A5N6U7Z0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_148118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7Z0"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="276" mass="32006" checksum="52DBCE70768F7A0F" modified="2020-04-22" version="1">MSERKVLTKYYPPDFDPSAIGRTPKHLRKQGPKVITVRLMAPFSMKCTQCGEFIYKGRKFNARKETTEEKYFSIPIYRFYIRCTRCSGEITFKTDPKNMDYTAEKGAKRNFEPWRDPKNETYNETEEQLLDRLEKEENEEHERAERDKMAELEEKMLDSKREMAIADALDEIRTRNARIERNEALGDEAALAQVKEEVDEQKLKEEQEIEEAARRAFTTDSGEKVKRLVEESNGATPDPKQSEIPPPPPSFARVKKAKKPLPNSLGIKKKAKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U841</accession>
    <name>A0A5N6U841_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_135430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U841"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="15">
        <location>
            <begin position="62"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <source>
            <strain evidence="8 9">IBT 18842</strain>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8R1"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="155" mass="17133" checksum="8AFCC43A5DD61660" modified="2020-04-22" version="1">MCNSDIFLAILAIFFPPVAVWIKVGICTADSIINLALCCLGYVPGLLHAWYIILKYPEQDPDDPFYEPIPGNSRRDAENGRITYYYVSHQQNQHPSQRGYGTVAPPTSSPQQQRQPAPKPQNEPAPGSSSDQGHSDSRPPPTYAEAVKGDHKVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8U6</accession>
    <name>A0A5N6U8U6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8U6"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="154" mass="15518" checksum="034016F52A2FDAFA" modified="2020-04-22" version="1">MSTTTTAAATTSTACTGATQWQIPIQDAACALHKTGNYSSIMDKCCTPAKVSTTDDGCTLYCLAQGQTTGDLQDCFRDQGAQYQDIFCNKSQKNATATASLASSTGSKTGSSTGGSASSTSSDSAGYAVQPAVSKGGLGVLAMMFCSVLMGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Y5</accession>
    <name>A0A5N6U8Y5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8Y5"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8155062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="450" mass="52367" checksum="E6329FCDD40E7818" modified="2020-04-22" version="1">MDGWTDFFFQGCSLKVIKLFRDLPRDPEFREFQESQSWQLGRRASDNMPPGHDILVLWMTARKGKSRTQYAAKTFADFPRERAEARIRTSGLKNHSVEEVQKQLDPFWLESRAFEHVMRCCSNSQKIYFPRYFGVLKRIQRQDYPLSYLLRPRAIVLEAIKPELASRRVLAANSPTANRSKSYEAFSQALDQMALSDFERCWYRSLFSDRFRRLLVLHDIGATHGDVRDDHFRLPGDFYDTVLYDFSSSYTFYPTWPCIRRPKPLSAMTSNEQNILLEILLDRAEQCDLRHYFARSLQLSPQVVEGLCSQTINSEIANLELIVLKVMVRPDEFSMPSLASILPFLEAIRPENKSTWHISRARLLQYYDSAWVLYPRHKEVGEMTLVSLSEKAFLDTDTLPVDDQHTFFLLLFPRSWDIGEAVHRLMAACSDLILSGKQGSVLSRAQFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9I6</accession>
    <name>A0A5N6U9I6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9I6"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="55"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8155268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="402" mass="44236" checksum="07897B69DD03B6EB" modified="2020-04-22" version="1">MSDSDVQAFFGESVLPADANASSYLTLAAADKAGTFIRRDYEKPPSKGFASPVENPDAVYWIASCTKLLTSIAVLQNVDKGLLQLDKDISSILPEWKAPMILKGFSNSDEPILKPAKNCITLRHLLTHTSGMGYPFFNPLIGKFQSALGNGPFFRDTIADTFPTILLREPGSRWEYSPALEWAGQMVERVNGMKLGEYFQRNIFDPLGIKNITFHLTDDMRARLVPTWFRSNGGLVPGQFPIPDPIKDAFGGGGLYSTATDFLTVLHSLLQDDCPLLSKRGIDSLFTPQIDSDMLSKYAVHEADPRSRAVVLGSLPPDTKISWGFGGLVTISDTPSGRKSHSLHWSGMPNCFWWVDRQSEICGLLLAQVLPAGDKQTVDLLTAFEDLVYSMNTGHSSSERPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCZ2</accession>
    <name>A0A5N6TCZ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_167603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8144126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HUPs"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="569"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="403"/>
        </location>
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            <begin position="540"/>
            <end position="560"/>
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            <end position="231"/>
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            <begin position="240"/>
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            <end position="265"/>
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            <begin position="277"/>
            <end position="297"/>
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            <begin position="306"/>
            <end position="321"/>
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            <end position="396"/>
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            <dbReference type="Pfam" id="PF00582"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="680" mass="73842" checksum="06DF2979A6E5BF83" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD71</accession>
    <name>A0A5N6TD71_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">Membrane-associating domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_167074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742563">
        <property type="protein sequence ID" value="KAE8144338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
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            <end position="72"/>
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            <end position="108"/>
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    </feature>
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            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="168" mass="18692" checksum="06F3E1BCF8A0357F" modified="2020-04-22" version="1">MLKPRQLPAPLFRAMALDFPWIYPVRVIQVIFAIIILGLTAYIVGVYNNDTVNFMLFNSIWTAFFATPYLALAPVHFPQIAHRYVIPAVEFITMIFWFAGFIALGVLLPAPRFCYWSACNCAQAATVFGAFEWVLFMATSIVAVLGALRTRSSPSTKPTPQSTAHVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDH0</accession>
    <name>A0A5N6TDH0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">BDV25DRAFT_95868</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Fatty acid synthase is composed of alpha and beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 23">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="ML742533">
        <property type="protein sequence ID" value="KAE8144413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
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    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
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    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
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    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
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        <property type="entry name" value="FAS_alpha_yeast"/>
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        <property type="entry name" value="FASI_helical"/>
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    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
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    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
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        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fas_alpha_ACP"/>
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        <property type="entry name" value="FAS_I_H"/>
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        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 23 26" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="28">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="29">
        <location>
            <begin position="1094"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="24">
        <location>
            <position position="1276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1743"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1744"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1745"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1843"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1844"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="26">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAE8144413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1860" mass="204882" checksum="D7CF1A4228798CCA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDS3</accession>
    <name>A0A5N6TDS3_ASPAV</name>
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        <submittedName>
            <fullName evidence="12">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_167231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742595">
        <property type="protein sequence ID" value="KAE8144271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
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    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
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    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
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    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
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    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
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        <location>
            <begin position="743"/>
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        </location>
    </feature>
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        <location>
            <begin position="960"/>
            <end position="1057"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="233"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118490" checksum="F47F1E0CBE16D0A1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE09</accession>
    <name>A0A5N6TE09_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_134590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GT8_Glycogenin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="36268" checksum="03331FB4D9FDBBD9" modified="2020-04-22" version="1">MADFHSSSGTQDQENKNNNPTNQIWASLITNLSYLPGLLTLAYSLQSTQTVYPFVALYTSTFPAEGLAALHARGIRTQAIATVQPDQSKQFIQDPRFQETWNKLIVFSLVEYERIILLDGDMLVRRNMDELMHIPLDGEEERVFAASHACACNPLKKAHYPEHWVPANCAFTTQHSDPNRAQTIGAPTDAGVAMLNSGLLVVRPSLSAWTEIQRALHTPQRTDTYNFPDQELLSDVFRGRWVALPYVYNALKTLRWPGVHDAIWRDEEVKNVHYIFAKKPWQEDPHEEMEETSRWWWEARDQRQWSEVQKGITDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TER9</accession>
    <name>A0A5N6TER9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_145199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ML742423">
        <property type="protein sequence ID" value="KAE8144865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TER9"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="277" mass="30400" checksum="B60EA1BE32075A72" modified="2020-04-22" version="1">MDMITVGVLALQGAFYEHLQLLKQAVGLLTAANATASQWEFIEVRTPQELERCAALILPGGESTTISLVAARSNLLEPLRDFVKVHRRPTWGTCAGLILLAESANRTKKGGQELIGGLDVRVNRNHFGRQTESFQAPLDLPFLSSAEQEQASFPAVFIRAPVVEKILPHEEGIQTSEIERDETVVAPSKHAKDQAARDAMGTDVEVLATLPGRAARLASEGRNIDADKEAGDIIAVKQGNVFGTSFHPELTGDARIHAWWLRQVEESVKRRHEIEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TET3</accession>
    <name>A0A5N6TET3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_166020</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="ML742432">
        <property type="protein sequence ID" value="KAE8144807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TET3"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1043"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="278"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8144807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1175" mass="123978" checksum="BF59CB9AE04F1786" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TET7</accession>
    <name>A0A5N6TET7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_89825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742473">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8144621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="174" mass="19426" checksum="06913BDF0E65DC93" modified="2020-04-22" version="1">MPGPQIACIGIIGKADNPLHISLFPPYQNATIEFSFLLNSCLDIFDTRQKQTSVDQDLGLLHAVDERLAAYGWLTTSGLKLLVVIDLIGQPISTGFDKRKGPTRTALKDPDLKPVFRALQTAYIRLLQNPFYAPDEHTPAVKDRTPNSKHQQITDNKFVAEVRRIGEMWTLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEW3</accession>
    <name>A0A5N6TEW3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_165823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742415">
        <property type="protein sequence ID" value="KAE8144913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEW3"/>
    <dbReference type="OrthoDB" id="4499133at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="208" mass="23145" checksum="7C661794DEFE0BA7" modified="2020-04-22" version="1">MLDTYKRRTGSPCYSTDTKRIVAIHITSQVMATAAEFNSPGVFRRVRLNLRVHSPMSKDLDSPHRSALAVLSQGKLQRETKSHTPDLRRCLGHHGIFHKCVKAAQDEARQSIHTRFCENIAEDSRNSSTEHESTASPIRAQITRAIKAMSQRRSSGASASPQNELIQVPPYDPPKRTNLAVLRRLYEAKLIPGQKVLPEAGLRSDTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFA1</accession>
    <name>A0A5N6TFA1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_166037</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="ML742433">
        <property type="protein sequence ID" value="KAE8144799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFA1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="293"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8144799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="449" mass="51730" checksum="8D52735BF8DD1C67" modified="2020-04-22" version="1">MSDQAILRITREIKQIQQGPDLSLAVDYDETDIRNVHALILGPPETPYQFGFFEFSIKFGKDYPTNPPNVRALTTNKGRCRFNPNIYASGKVCLSILGTWRGERGEQWSSAQGLESILISIQSLLSNNPYENEPGYDKANSEEDKVLMESYVEKIRHETLRLAVIEPLELSLGILPGAKGTVAEHSSANDGDEDDDLLLNDDDKQICRFMDIRKRRFLWYYSSYMQSVDTAEPVSWRKRKFQTMPFENQGNSMDGHFDYLELKERLTLLKDKIIGEVHSWTAEGDKAKKQELGIAVNLQRQFEQIAEDLKRQKNFAVDLSLIDDNPFLWKLTYFGRPMSHLDGGIFKFRIHISPRFPDEQPRVFVETPLPHVRISQLGVLCYLPRRTEDMRSHIEGIVTALEEESPPYDPRTTVNPEATKLFWGGPEDRKRYYRALRRAVEKSAEEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFI0</accession>
    <name>A0A5N6TFI0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_165421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742388">
        <property type="protein sequence ID" value="KAE8145092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFI0"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001014">
        <property type="entry name" value="Pre-mRNA splicing factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001343">
        <property type="entry name" value="Pre-mRNA splicing factor, putative (AFU_orthologue AFUA_8G04590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000003">
        <property type="entry name" value="Pre-mRNA splicing factor, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000698">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="PRP4-like"/>
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    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="6">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="534" mass="58533" checksum="A3700A6821AD7804" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFL2</accession>
    <name>A0A5N6TFL2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_81470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
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        <property type="protein sequence ID" value="KAE8144909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000011">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8144909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="625" mass="70671" checksum="448DCBC99B6A5D11" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFN2</accession>
    <name>A0A5N6TFN2_ASPAV</name>
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        <submittedName>
            <fullName evidence="4">Spo7-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_165323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742383">
        <property type="protein sequence ID" value="KAE8145127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="52000" checksum="794C8FBC4BB8D65A" modified="2020-04-22" version="1">MASASLDQLVKGSPATGNPLPSSSTNSDLSNSTQQSYHQEYTDPSSPPHPSTPDPLSTLPSSPPQIYLNLLILESSLRAQYLALRERRRQNTFFLLLLAAWIAYFAYALFLRPREDGRGVGGSVYWVVEMGEKVALLGGVVTALLVWGTGQWERGVRWPRRWLAVANRGLRTMNTKIVVIRGPWWQELLSYLSFLFPFSLPIFPSPTGDFQYIERPASEKRGGRPLHPYYNVDTESGLVEEDLSPGGDYIRLLLLPKSFSPEFRGNWDDYRVDFWEKENDRRAQLRQKLRQKERQLAQQDGGWFWWFGFGWKASQRRRFAAATIAKSAEDRGHHRPHHQSSISKHSHDLKTPLRRSTRSESHSRTPSRSTTPVDTDDRPPSRSSATSRPRRGSLTPNSTASGSEQSQQHRRKKSKTITRGISPLTQAQVREGVRAPSFSSDDSGVFEEKDIPKDDPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGU5</accession>
    <name>A0A5N6TGU5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_164372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="ML742333">
        <property type="protein sequence ID" value="KAE8145563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGU5"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="833" mass="96096" checksum="C82F96015C0C2D89" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGZ9</accession>
    <name>A0A5N6TGZ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742324">
        <property type="protein sequence ID" value="KAE8145654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGZ9"/>
    <dbReference type="OrthoDB" id="4497052at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="649" mass="72314" checksum="60BF1BAC0C1F8106" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THH0</accession>
    <name>A0A5N6THH0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_163782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742310">
        <property type="protein sequence ID" value="KAE8145818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THH0"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="346" mass="37543" checksum="84D85EA58D6B6CA5" modified="2020-04-22" version="1">MGSSSKKKKEKQKDFQKAKLKVGKAKGKPENFTDTSFKTKGITLTQQSLTLNAPTSNSQFSHHLSLLSSKSDSQRRDSLAHLTTSITARPVTSPLPQPVSVILPTLLPLILDANTGVRTQLLKLFRSLPAPDVQDHVLQLLPYIRAGMTHLAADIRVSAVEVLTWLVDVAGPEVVSCAGGWIKTLNCFLSVLGWHTEESAKWSANRASFGKSGSKGTPMMKVLIALGEFLNAGIGAPEPTDVEMGDSEQTPGVSNWEFPVGLAAVHMVPDTASPYAYLNLFGQPRDAEGEMYETWEDRYRVFSTRFMSAVERGVENARKEGGELGRAISGVSKVLKESSAYGRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THK6</accession>
    <name>A0A5N6THK6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_163789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742310">
        <property type="protein sequence ID" value="KAE8145825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THK6"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF272">
        <property type="entry name" value="OVO-LIKE ZINC FINGER 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8145825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="400" mass="42991" checksum="0E149B00A34794F4" modified="2020-04-22" version="1">MGTALDALTTPQPLSSRRPAAPSLPSFELPPPNFHPVKYHSHPTHPQPPTNPSVNSLLTPPASTQSGETPIATTATALTSTAGSASADPASSYQPYWQGQNTYTSASAAPRQSWTSTVNPPYPARETFSPSVSNLSRNPATSPPGADTLPSQPYDMNQLPPFQQPLTASVPPQHHSMTHAMLTAQNALPNPPPAPPSLPSNDPYMTKSSSAPAYAGIQPMTSPAAYAPYGQPGLGIHPPGRVASNPHTHHLNYQRQPWPSYSLPAMNGPVMTNVHNPNGHMSPMGNLQPGLLGFNSGYVASMQAMCPPHPGHAPGPTNDRPFKCDQCPQSFNRNHDLKRHKRIHLSVKPFPCTHCDKSFSRKDALKRHILVKGCGKDVTSDAIKPEHQVKQEDKELDPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THZ2</accession>
    <name>A0A5N6THZ2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_170105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742299">
        <property type="protein sequence ID" value="KAE8145953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THZ2"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="49"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="448" mass="48480" checksum="F834E396829B317D" modified="2020-04-22" version="1">MAASQAANLVEKAVGHSDNASVTTDVSNYAKGTYGEETGEKIKATVWQGKNSVEVVEMPKPRVVDEGDVIVKVTGSTICGSDLHLYHGVIPQLEKGDVLGHEFCGVVERVGPTVKNVKAGDRVVAAFPIACGECRNCQKKLTSACERTNENSITNAMYGKRTAGIFGYSHFTGGFAGGQAEYVRVPYGDVNLLQLPDDVPDEKGLYLSDVLATAYHCVVDTGVEKGDVVAIWGAGPIGQMAVEFSFSQGATRVILIDGGAGAWRLDYIKSKIPKLETVDFSNLPKGESITSQLKKIVPGGPDVALECAAGEYAKGWAHYFEILLGMETDTSEILNEMITSVRPFARIGITGVYAGYANHFNIGALMQTGIRLIGNGQAPVQKYWEHLLELIRQDEINPLDMVTHRVQLDDMAELYAAFERRQEGMQKVYVTTRFSHPPAAGSPELTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI30</accession>
    <name>A0A5N6TI30_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_144132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742295">
        <property type="protein sequence ID" value="KAE8146003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI30"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF24">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68360" checksum="801F94972D55185E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIB3</accession>
    <name>A0A5N6TIB3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_60964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742308">
        <property type="protein sequence ID" value="KAE8145839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIB3"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000885">
        <property type="entry name" value="Putative GTP-binding protein EsdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29303" checksum="2A4C36F8E5DAAFFB" modified="2020-04-22" version="1">MSAVQLKFTLRTSSNVKTVHLVGSWDNYSRQIPLSRDDGKPGSWVGKFRFQTSMLKLGGRYWYYYIMDGYHVSHDPAVEYTVEPTTGRKLNILDVPGGSKKPSTSAPKSRLGSSEVVKGRAPSPSKIHHPKPSKPYASRQIRESDFAPTMEDLTRRFAGSRMSDEYSLSNSPPSSVGSSLSSRSSRSDGSTSPSSLSSMSDPSSVCRCERYGITRKGDRVKLDCGGSRCGYVTESSEASCSESDSDEEYRRARRGVRRQGIVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIZ0</accession>
    <name>A0A5N6TIZ0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_163199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742288">
        <property type="protein sequence ID" value="KAE8146071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIZ0"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="480" mass="53650" checksum="F9466305B25540AB" modified="2020-04-22" version="1">MAMAATPSRPFDYLESLPGTTFYKLYQQPSTALAIFRRMLPDLAKCFVMALLYLKDPLPAANLEVWVKAESLKERDNALSILGRLHILSNTMVADNTRAYKITDPFASSLRQALTGAEKTQSFGVLSHLSNSDSRSIAELDEYARRQWEGVLGYMVGTSGLGIQRDVNLSKGVKQLLQAGHLVEIRDRRVEITQDGFAFVLQDVSVQVWHILMLYVESADAIGMSSVEVLSFVFLLSSLELGQSYDKKHLTSNQLRTLTDLADFGIVYQESPDTNQFYPTRLATTLTSDSSALSNPISGSLSGPTGGTTDKAGSGFIIIETNYRLYAYTSSPLQISLIALFTTLKYRFPNLITGKITRQSVRRAIEMGITADQIISYLATHAHPQMRKHNVSRSTSNQAGIPPSVLPPTVTDQIRLWQLERDRVKATAGFLFKDFVSLSEYEAPCRYAEEIGVLVWKSDRKRMFFVTRHEQVAAFLRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJC0</accession>
    <name>A0A5N6TJC0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_162441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742262">
        <property type="protein sequence ID" value="KAE8146436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJC0"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22771" checksum="3AE2B88987898809" modified="2020-04-22" version="1">MESHQSPEARPRDSSTLFKILHWDKFFESDAPPRLGIDVGKRLPYTTTSAFTVGMAIGASHGSKKAAYRFRAENAHRFPTSSTGWFHYHKTKNYTAIVGGVKEGMKMGMKLGFGALAFCLFEETVDYARHDRRDFLSTVTAGLSFSGIYSLLARHDVYTAARTTKLGLKLSLAYGLVQDALESMKGNRPAYIEFLLGNRRSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJL4</accession>
    <name>A0A5N6TJL4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742274">
        <property type="protein sequence ID" value="KAE8146271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJL4"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="37679" checksum="03CC74D0BDC1848F" modified="2020-04-22" version="1">MAPPYISITEIPTVSLLYKLGRLVPIANPIIPPSKLFNDTISLIRNDITKLQGVDCIVNAANESLLGGGGVDGAIHRAAGPNLLQECHTLDGCDSGDAKITSAYELPCKRVIHAVGPVYRYELRGGDDRPETLLRSCYRRSLELAVENDMKSIAFSAISTGVYGYPSGEAARAALDETRKFLANPSNIGKLERVIFCNFERKDEIAYEEYLPLIFPPVEQDLPKSTSLKSESQSTAAGESSPSLEMLAAKLPDPPTVDPAAAGQPGSKKQKVDTDDATQNSKFHTDERSEDDWEEVDKSDDGRTEQLDDEPVEVRPPSPTDVQSVQSSGIIDMVDSHSTGSLMGKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKA4</accession>
    <name>A0A5N6TKA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742243">
        <property type="protein sequence ID" value="KAE8146767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKA4"/>
    <dbReference type="OrthoDB" id="4186099at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787181" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="90" mass="10223" checksum="CC218B06A1288C15" modified="2020-04-22" version="1">MKPIYILTLLAPTIYARACTQYLLYCGSTLKTIDTGYDSIIRTKLQQRGIEVTDHSVEDSWWYCLDFGDINYIDTCEKCVNAGSGNDDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKX4</accession>
    <name>A0A5N6TKX4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_161319</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="11"/>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8146998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKX4"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
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    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
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    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
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    </dbReference>
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        <property type="entry name" value="C2"/>
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    </dbReference>
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        <property type="entry name" value="HECTc"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="WW_DOMAIN_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
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        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
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    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="333"/>
            <end position="366"/>
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    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="393"/>
            <end position="426"/>
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    <feature type="domain" description="HECT" evidence="17">
        <location>
            <begin position="482"/>
            <end position="815"/>
        </location>
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        <location>
            <begin position="134"/>
            <end position="237"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="253"/>
            <end position="353"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 13">
        <location>
            <position position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00056180"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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            <dbReference type="PROSITE" id="PS50237"/>
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        <source>
            <dbReference type="EMBL" id="KAE8146998.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="815" mass="92461" checksum="6FE64D1560AAC49E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKY2</accession>
    <name>A0A5N6TKY2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_41891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8147007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
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        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL17"/>
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    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
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    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
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        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
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        <property type="entry name" value="RIBOSOMAL_L17"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
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            <begin position="170"/>
            <end position="194"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="194" mass="21946" checksum="234D75AF3DDEE193" modified="2020-04-22" version="1">MAGGATKYRHLSRKSSHRQALLRNLVTSLFKHESITTTWPKAKEAQRLAEKLITLGKKNTEASRRSALSVFYTPHDILPKLFGSLRERYAERPGGYTRVLRVEPKKDDQAPSAILELVDGPKDVRFAMTARTVARQRSQGLETLNELTTLNVRKVTRYRKDGVEELEKEINRLGLDGGKEEKPAKTSESSESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLA6</accession>
    <name>A0A5N6TLA6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_143115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLA6"/>
    <dbReference type="OrthoDB" id="5406275at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="826" mass="90344" checksum="696767FA331B7562" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLM2</accession>
    <name>A0A5N6TLM2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_37456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLM2"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="236" mass="26349" checksum="63DD209EC071FD29" modified="2020-04-22" version="1">MDMPEVAQQTSAFLPIQLDRASISHSSISTPVHRPRHNPTASPWSVGQAMFAVMGGFAIETEYIDLMDAKRTIRRLVTPEGVAVLVKTGHLPFIDREDVAERSKADVFAKGVVVIQIIWFALQVLGRLLQGLSVTPLETHTAIHVGCTVFVYASWANKPYNVLRSMLITGPEMQYIGAFFNFSDLSGVVYNKQCEKYEVERMEYWKDRIIQASRGVSAFDMLLFTGSIGLHEVIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM98</accession>
    <name>A0A5N6TM98_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_132258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742218">
        <property type="protein sequence ID" value="KAE8147221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM98"/>
    <dbReference type="OrthoDB" id="3000060at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="563" mass="63830" checksum="351C4F29F794E0B3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMZ0</accession>
    <name>A0A5N6TMZ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_132034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742205">
        <property type="protein sequence ID" value="KAE8147481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMZ0"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="397" mass="42993" checksum="D5185A264AD29965" modified="2020-04-22" version="1">MPSKITVGVAQARTHSTLNETLLALNRITQHAASRGVHLLLFPEAYLGGYPRTCNFGTAVGARDPQGRDQFLNYFHSAVDLGDTPAGAGDDWVQRKLPVAEGKNHRGDGTRETLERVARETGVFIVVGVIERAGGSLYCSALYVDPAKGCLGKRRKVMPTGTERLIWAQGSPSTLKAVTTHLNGVPVTLAAAICWENYMPLLRQSLYSQNVNIYLAPTADARDTWLPLMRTVAAESRAFVLSSNQCVRYNELPKWITGQQNKQVSHLRKRSITSEGPHEIVWPDADKEKAASGGYQPVSTEYVCRGGSCIVDPQGQVLAGPIWEVSADDVPDSSVTAHAAGVDSESISAVGDGLIISHIDLEDCERGRLDLDLAGSYSRNDAFKLTVEGLDLNPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNF0</accession>
    <name>A0A5N6TNF0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_159461</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742188">
        <property type="protein sequence ID" value="KAE8147835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNF0"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="403"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="764" mass="88466" checksum="CE18AF735AB63765" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNG0</accession>
    <name>A0A5N6TNG0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_159547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ML742189">
        <property type="protein sequence ID" value="KAE8147827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNG0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031603442" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="478" mass="52648" checksum="96E0DA485F13BD2E" modified="2020-04-22" version="1">MWLSSPTWLLPLTMAGAVQALPKGAKIGTTVSQTTKDGITYNVFNHAATGAKLEYVNNTGICETTKGVNTVSGYLSVGEDMNMFFWYFESRNNPKTAPLAAWFNGGPGCSSLIGLFQENGPCHFVDGEEEPSLNEHSWNNFANMLYIDQPIGVGFSYGNNDVTSTETAAPYVWKLLQAFYDHFPQYESRDFGIFTESYGGHYGPGFASYILEQNEAVEAGAVQGEKINLVALGINNGMYDLELQEKAYITYSYNNSYKQIIDESTRDSILEDYESDCVPAVRKCQQTKTDADCRDASSVCGSAIEDRIMYSGVDFDVYDIRQGSDDPYPPSTYSDYLARSDVQKAIGARSKYSECASLPGAKFRRTGDIARSTLPDLSEVIKSGVNVLVWAGTSDWICNVDGSLAVADAVEFSGHDEFQAKSVEAYKVNGKETGNFKSVDNFHYLAVYDAGHEVPYYQPETALQAFTQILQKKPLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNR5</accession>
    <name>A0A5N6TNR5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_159281</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742183">
        <property type="protein sequence ID" value="KAE8147950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNR5"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8147950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="737" mass="80875" checksum="AE9025A429E895D6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNU9</accession>
    <name>A0A5N6TNU9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_159217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742181">
        <property type="protein sequence ID" value="KAE8147995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNU9"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8147995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="32761" checksum="5E569B2D23D8FDA3" modified="2020-04-22" version="1">MSGPTKRPQALSQQLVEGIPDAGTFEGIPKIRQVAQDSVGPRVKDKVVIITGANSPAGIGRASAHNFAHNGAKAVYICDYDATYLATHKREIESLYPGVEVHTRQFDAADEAGVKAVIDDAIQSYGRLDIFFANAGIVGQTKLFTDVSAEEFMKTLKVNTLGVFLAVKHASNGMKQTSDAKPYPSGSIICTASVAGLRSNAGSTDYSASKAAVVSIAQTCAYQLAGTGIRINAICPGLIETGMTQSVFDAARARGTQRKIGQLNPLQRGAVADEVARVALFLGSDESSYVNGQAWAVCGGLSAGHPFVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP11</accession>
    <name>A0A5N6TP11_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_142103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="ML742175">
        <property type="protein sequence ID" value="KAE8148096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP11"/>
    <dbReference type="OrthoDB" id="4467523at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="308" mass="36366" checksum="CB8349C13D4EA8C1" modified="2020-04-22" version="1">MASAVIDKHKPRDWDEKPDEPIRIPDLFVSFLCQEPKPHPSHEKVKKASEDWFADVLHLSKTQRSKHWDYDLPYFVSVWMKHASEESYKIVSDWDNWVFCFDDLFDDDDLERNDTDRAAKEVEVVLNITKGKHDPKDDVHEGVMISALRYMYCDVWERIVQNSTPVIQQRVAEAMEYYLQGILNCVRVEAGDIERDLEKLIEFRRGGIGVEPCIALAEFAGKLNVPEKFFRSSVAQELRNCTTDLVFLQNDIISYHREHDMGVTHNLISFLRSEGYTQQQAYDKMDEMLRERYKMWYRILSEIPIYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TP71</accession>
    <name>A0A5N6TP71_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_158869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742172">
        <property type="protein sequence ID" value="KAE8148158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TP71"/>
    <dbReference type="OrthoDB" id="4221933at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="268" mass="31467" checksum="0F8555AC7A35A427" modified="2020-04-22" version="1">MNPWQRNVRMIHQVSEVLDLDSAKWDKISDFIALIEAMREGVTQIDEDSRIPDYQINILFLKELKSRPEWDPWATDMLRSRRLDSPAPAEKLSFRDLAELAIEQEKLTLGMLKSTHHARSESTPLASHNAPPNFHKPSQEEINAFVIQQMKCDGDNSHRNHAYKTHRRRPSQEEINEYVIQQMYREQDHKTRTRSHSQPESKVHSSHQRAKTTSCTFCLDPNHQANNCWRRFRVALEAPHGNYLPKRVEYRTEIPGQPPMYRSGFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPI6</accession>
    <name>A0A5N6TPI6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_158781</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742170">
        <property type="protein sequence ID" value="KAE8148200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPI6"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="94"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8148200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="708" mass="78842" checksum="DBEC3AC5103B2586" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQD7</accession>
    <name>A0A5N6TQD7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_16257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQD7"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="288" mass="32273" checksum="DFA6718F35DDA68C" modified="2020-04-22" version="1">MTTPAFQTLQSQYSSALKRFAASNKNLEILTSIPSNHAQSPPPTPSPDVLYVLDSSFNPPTCAHRRIAISAILENPGHAPRLLLLLATQNADKPSKPALFEDRLAMMELFAKDLLAYLQSHPSASRQQSLPGIDIGVTKKPFFVDKAAEIESAEIYPTSLEQVHLTGYDTLVRIFDPKYYPPEHTLQPLGPFLSQHRLRVTMRPGSEWGGAEEQKQFLLNMARGGMEEQGGRREWAQRIQLVEGRKPEDRPVSSTLAREAIQSNPQDLPRLVPDNVREFLLSQQPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR49</accession>
    <name>A0A5N6TR49_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_157365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR49"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="91" mass="10212" checksum="E254C7141091C49F" modified="2020-04-22" version="1" fragment="single">MTRAQQTLSVLLLVSSLYLVLYLGLVPLNGIVQRDIIPVLPFYAVICFGCYLLGRLGVAVLTFNDVPEAHQELQKEIEQAKAELRRQNIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR60</accession>
    <name>A0A5N6TR60_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR60"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025049053" evidence="1">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="195" mass="21840" checksum="919157178D6F0710" modified="2020-04-22" version="1">MHSFIIIFSIIQFFFTFSHAIPQQSISTDIYYWPVPSPEPSILARVSYDPKSLKINSTTYSPPGTTQDASLGPVRIGLYASGEVGLRQWTGTLTSWPSLMGHDEQNPMLRLHLDPSNEIYHATLASSSEPVVADPNLTFFPIEIGPRPHLNRPLVVGPDGINSDEVVEKTFFQKYWWVFLIITFLALSGSGEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRQ3</accession>
    <name>A0A5N6TRQ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_11207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742145">
        <property type="protein sequence ID" value="KAE8148811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRQ3"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48006" checksum="7606A996CA0E6E72" modified="2020-04-22" version="1">MSSTLSTETPEKVPDDSSKLKTFLSILRKFMGVADIASVRFSLPAHLLEPTPNLEYWNYLDRPEAFASIGKSDDPLGRTLEVLRFWFTKDLKYIKGKPCKPYNSTLGEFFRATWEIDNTLSGVEVSSKMGTANDPSTVTHSKPGVAKVCYLTEQTSHHPPVSAFFIDCPDQGVSARGFDQISAKFTGASIRVAPGQHNLGIFVNIAHRDNEEYQMTHPAAHLGGLLRGALAITVSDTCYVTCPKTRIKVILQYLEDGWISRAQHRVEGVIYRYDPDMDTTTRIKDVPEDDVLARISGSWHGKVYYTLVGSNEPRLLIDIAPLFPMPKNVPPEEDQLPNESRKFWSSVTTAILDKKYSQATKHKQDIEERQRQKAAERQARNETWQPRFFTGAVTPSGKPELTEEGYKVLEGLREGNYRLMESETQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS94</accession>
    <name>A0A5N6TS94_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_5143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS94"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8149215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="292" mass="31030" checksum="698F97E1B1CBF991" modified="2020-04-22" version="1">MSNIKDSNVHGPDFREAKPPQGGSTIPVADLFRLDGRTIVITGANGFLGTTLAIAILESGGDVVCLDLPSSPTAENWQEVENAASKHTAVLKYVPLDVTDGDMVARVFAEFIPTLRYPLRGLVVCAGISRNGPAVDFPISTFRQMLDVNVSGAFLAAQATAQEMNRSNTSGSIVLVASMSGYVSNKGVDTAGYNASKAAVHQLARSLAAEWGSRKDMPLIRVNSLSPGYIRTAATAEALQKPGMEAQWVGDNMLYRLSTADEFRAPVLFMLGDGSSFMTGSDLRVDGGHCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSW3</accession>
    <name>A0A5N6TSW3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSW3"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="438" mass="48409" checksum="6CD94590A179A800" modified="2020-04-22" version="1">MDLANTLIRSVVRAFYETRHILVVDALFIHSVLHAEDLAFLLGMQQKDLRKLCAKLREDRLIAVNTRAEIRDGSTRPVNREYYYIPLHPVIDAIKYKVSKLTSTIKAQYTPSEERKEYICLRCGSEWTELDVLSLYSDEGFECQNCGAILERTEDVKGAEGIDRTGHEKNSKLMAQLDNMLKLLKQIDSVEIPPNDFDTAWDHKVDVVRNQSTHPTRATIVVPSKKQEAVRGNIKTDAAALEISLTSTEEKSAAEQAEEAARRAAVEKQNALPVWHTHSTVSTNSGNANIKSENDTDVKSEIKEEEDQKPGLDALDDKVAAYYAELEREKALQEQEESSAEEDSDEFDEEFEDVGGVSASDAASPAVGGSGPTSAPTTTTSVGIKRELDTDSGTSALQTASATPPSAVEDGPSAKKIKMEPEVKKEESDEDDEEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTJ5</accession>
    <name>A0A5N6TTJ5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTJ5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="150" mass="17269" checksum="DA9810C03192BA77" modified="2020-04-22" version="1">MPLLPDLTPTACFEYTNEDLHVEYGHIDALGFYISVYDLRLKLRNEQDPDFFHLSTEISWNGSGCYLTARTGEYGIGTRVSVPTMRRLWEIYGAEEQHLRFMDRFVVVRRTLDAVLGHRVQIHTLQLDGLAQVETVEILHIESSQGDNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTS5</accession>
    <name>A0A5N6TTS5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_172772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742120">
        <property type="protein sequence ID" value="KAE8149519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTS5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="494" mass="54362" checksum="CA69E781F0796C70" modified="2020-04-22" version="1">MGRRLGLFRAVYLVSASCMGSFAFAFDTGVISGVLTLESFQEDFRYSASSKTTVNSNAVSILQAGAFFGCFFTMPIASRLGRRSGLILSSLVFTVGTILQVINAHTLGTFYAGRVIAGLGIGAATALIPMYSAEMAPKEIRGRLGACFQLFFALGVMIAYWVTYAVSENQPSATKQWQIALGLQLLPSTLLLAGMCTVKESARWLATKGKKEKAWESLKWVRGGEETEELQKEFDEILAGIEEESRIKDSFTIRELLLPVNRYRLFIAISIQLCAQLTGNTSLAYYANQIFEAVGGGSKSKLVTGFFGVVKVVGVSIFQLFVLDRIGRRIPFMVGAFAMGTFMLIIACVLATHPTKSGENNSSPTSAGIAMIIMTYAEAFSFNMSWGPLPWLYVGEIFSNRTREVGVAAGAASQWLFNFMMSQVTPHAITNIKWRMFLMFAIFNYAIIVYSWFFLKETSKHSLEEMQEVFGGREPPKEATLASEKGEIDATVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTY1</accession>
    <name>A0A5N6TTY1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_120679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTY1"/>
    <dbReference type="OrthoDB" id="4779287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="139" mass="15530" checksum="2D69CFC99EF4F19C" modified="2020-04-22" version="1">MSSDLRVGWAVRRPNNCDDNEDGHNTWGKWYTCCPLEMQKFVDADNNAGCTVGGEPREVPKQCAGNSTLVLWSDPYGYFCCDPDRIGFANENHYKGCATTDEYNAGLRNESMTKVFREGTSSGKKPPLLSRNHESRGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUW8</accession>
    <name>A0A5N6TUW8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_115057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUW8"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="282" mass="30726" checksum="118C2711C0EFE327" modified="2020-04-22" version="1">MGAGASTQSPPPAEFASATCPVDHKTREVWLQQHKASGGAPHPLPSEDEQSKGKQQRPLSSDREVSSIPRAFDPVSKEASAPAPAPSPYSASHGTPSNAESETGHDEKSGNWIYPSERQFFEALMRKGNTPTSTSSPKELATSVASIIPIHNAVNERAWQQILEWEGQAPRSDPGSKKCGGPKLYAFRGLGVDPQFLSPRARINNLMGYQLPFDRHDWVVERCGGERIEYVIDFYQGKTSGGNAPGLAANAGPGRLSFYLDVRPKLNTFEGCRMRFSRYTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUX3</accession>
    <name>A0A5N6TUX3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_140399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUX3"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024898217" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8149881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="381" mass="41256" checksum="F653D2792955664F" modified="2020-04-22" version="1">MKPAGHLLFVLIALGLALLQSRRIGVRADDLILEDDDDDDQGTNADSGCPVPRKGLSSGTPQISTTYGCPSNDGKIYETSSGQYMYIQCCTDRTFGRNIGGASVLNLGECMDLCMKEETGTCRSVTWDSSGGNRADAINCVMWAHGGFSTDESRPGSHHAFLVEAPYVDQPDDEIDLCSTQCPGANHQVFTTQYGESFLMICGKRHGTAGQSQYVDSYEQCMSGCGMLVQCKSVDYHPRTGRCTFGDHGGEPTVDAPGYMSAYSMGCSGACKEYPKTPPAIDSHCPAPGDYHAAYWAIDNKAWQSRCSMWQYTGSSYTLNDGPISVENCMKKCQDDAACKWGTYLFATGKCLGYVNSWITTSGVDGQVKDYVNFAPVPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUY2</accession>
    <name>A0A5N6TUY2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_154900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUY2"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024820424" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8150175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="210" mass="23726" checksum="7786BFAC8046621C" modified="2020-04-22" version="1">MRFAVLVIGLLATLVSTVTATALTYKLEANEKACFYNYVDERNAKVAFYFAVQSGGSFDVDYQVVGPGDKVVLDGTKERQGDFVFTAQSIGEYRFCFNNEMSTFAEKLVDFEIAVENEERAQLPSRQGASPEQASALEESVYKLSAQLSTISRNQKYFRTRENRNFSTVRSTERRIFNFSVIEGLMMVSMAGLQVFVVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVJ5</accession>
    <name>A0A5N6TVJ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_154516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVJ5"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="136" mass="15855" checksum="BDF9FBDC4C939F6E" modified="2020-04-22" version="1">MSTILRTLRNLSRVGIKDFGHQMQNIGDTKAGTLIGIDRYGNKFFENMEEELPLRTRWVDYKEQEYDASQIEPGWHAWISYMVDQPPKADKLLQTGVRHWDLPEHRPNMTLSRAAFKTYSTTKPKYSAWDPVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVM1</accession>
    <name>A0A5N6TVM1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_154387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVM1"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="85" mass="9538" checksum="80F4DB736F11D5AB" modified="2020-04-22" version="1">MDDREKHNICRSFVFSFNYRLVTALKMSNNIVSATKLLALVTIVLGLWTDTSQQNIKSLRRGMIASLALSVSIILSGVVRNHECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVW9</accession>
    <name>A0A5N6TVW9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_139852</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVW9"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAE8150447.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="785" mass="85349" checksum="DFAB732825D5E5C4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
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        </location>
    </feature>
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        <location>
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            <end position="602"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="741" mass="83783" checksum="33AF477FC6DF9EC4" modified="2020-04-22" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="LaButti K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15301" checksum="7F9416F8583AA63D" modified="2020-04-22" version="1">MFERRAADRYRLRMHRARTVALTTDEIVEVRAAQRTFEGAYVRTALSQFSFALVVLKIFTSEFYSTGALFAIYGTGVLIIGLFRRQQGNRQFFSEVGEDGVHRNKFRTSGNAVVVLTALSIAAYAALIALTIRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="6" type="ORF">BDV25DRAFT_139389</name>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWV8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="GPROTEINBRPT"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="23"/>
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            <end position="418"/>
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    </feature>
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            <end position="292"/>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150872.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="582" mass="64770" checksum="2B2AB95482CA8CD2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX58</accession>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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            <dbReference type="SMART" id="SM01137"/>
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        <source>
            <dbReference type="EMBL" id="KAE8150880.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1863" mass="205514" checksum="5D57798882624979" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXR6</accession>
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        <submittedName>
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        <name evidence="8" type="ORF">BDV25DRAFT_100212</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Daum C."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphate ion transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EXS_C"/>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="246" mass="28206" checksum="EBE4646A2E325556" modified="2020-04-22" version="1">MYRIDRVTRFQAPFITFALLNAVYCSVWDLAMDWSLGNPYAKHPLLREVLAFRKAWVYYVAMVADVVIRFNWIFYAIFAHDIQHSAVLSFVIGFSEICRRGMWTIFRVENEHCTNVLLFRASRDIPLPYDVAPLHGEADHPTEEMQLQDPQQSTPQAPLPDVEHATPPTPGASLRGRALSRVGTIMASAHAQDFQRRKRPDELLEDNVPHRPGDSPEDSSEDDEDPGDARPYMDDNIVVEDFSYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYY6</accession>
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        <submittedName>
            <fullName evidence="9">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_138727</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742068">
        <property type="protein sequence ID" value="KAE8151598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYY6"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024833113" evidence="4">
        <location>
            <begin position="20"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="73"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="212"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="624"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="8">
        <location>
            <begin position="706"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="957" mass="107074" checksum="29C69C0407ADB7D3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ51</accession>
    <name>A0A5N6TZ51_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_171401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ51"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="27374" checksum="3E4076BDB60EF193" modified="2020-04-22" version="1">MNESKNPQITTVTLQQIAKMIDHSLLHPTMTDEEILAGLRIAKEYGVATACVKPYLIPLAKKELEGTDVLVCPVIGFPHGNSTTEVKVFEADAAAAAALSGDWEYVSNEIREFNDAVIRHGAVLKVTFENDYLEDSHIIRLCQICSEIGVAFVKTSSGYGFVKQSSGMYTYKGATVPHLKLMRQWSDPKVQIKAAGGVRTLDDLLHVMSLGVTRIGASATTAILEEAKNRGITDQPTEVAFRPMPDSGCGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZY5</accession>
    <name>A0A5N6TZY5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ4</name>
        <name evidence="9" type="ORF">BDV25DRAFT_84179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZY5"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8151937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="281" mass="31990" checksum="C48D77653158268C" modified="2020-04-22" version="1">MSVLASRGVLGVRALPRSCSVSVVGCRYIGFSRPTPKYPGHVPLNFVERGALAVGSAVGALLNPRRADLIATCGEATATPYFIYRLRDAMLSDPTGRQILRERPRITSQTLPLPYLRSLPENSVGRAYATWLDREGVSPDTRDNVQYIDDEECAYVMQRYRECHDFYHAVTGLPTFVEGELALKAFEFLNTLIPMTGLSMFAAVRLKPAERERLFSLWLPWAVRSGLSSRELINVYWEKVLEKDVDELRAELGIEKPPDMREIRRMIREQRKREKEKLQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0C2</accession>
    <name>A0A5N6U0C2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_170852</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0C2"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000006">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="16">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="15">
        <location>
            <begin position="252"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8152072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="699" mass="78621" checksum="FEF0CAF286EAB3EF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0I6</accession>
    <name>A0A5N6U0I6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
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    <sequence length="412" mass="45129" checksum="52FB0B731602CEC2" modified="2020-04-22" version="1">MPPFSTPFRLPASRRPNSARPGSQFASTPRFILSQTPSNNRRGSDDDLIDAESPESTPLPTGRVRRDRDTRPIPKDVIEDSDELGQSDGDPDSNSENAGEVDSEFEALFGPTRAKRRRVSLEPVSLDPETPFTQRRKRDNIQTSSPETSPTRDRAVNHIPPEATETPSTPAPTKPSFRSNPRFVLADSQLPSSTQPQFSTRVPASTAPPSSTQRKPAFVLPRSPSPSRGREDPLIPTPFSPSARALGRRGRRPGAPSYLPGGMAAEVRSWILEMGSKRDQMDLATEGVPDLQKYFLVVRVVEARQSSLANSGPLAFVRGRPVSSLDDENIESQLETRNVMLMGPPRARQTTPGLGPGNLVGVHRGLVWEVDLDQTENTVPEVGPEDTGSGKESIQMPGKWLVGMEWELISEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U134</accession>
    <name>A0A5N6U134_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_84238</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U134"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="482"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="870"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8151941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="928" mass="104010" checksum="D505D24F26DCC0E9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1A8</accession>
    <name>A0A5N6U1A8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742054">
        <property type="protein sequence ID" value="KAE8152385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1A8"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="520" mass="56739" checksum="00DE058B024478FB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1C6</accession>
    <name>A0A5N6U1C6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_127975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8152405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1C6"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002054">
        <property type="entry name" value="DNA mismatch repair protein MSH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="788"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="837" mass="93535" checksum="E192E2D01C750DAC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1F0</accession>
    <name>A0A5N6U1F0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_151127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742053">
        <property type="protein sequence ID" value="KAE8152434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1F0"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF4">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="32978" checksum="01DF4D68AA95F118" modified="2020-04-22" version="1">MVFPASIPSPLLEAVSSIALQEGTRDRFVAKVSPEWSTQHSTLGGYLNALMLSAVQKFNALEFGTDRFPDPIHVFVQFIHMVPPDQVVVSCQHLRVSSRQCVVRVEVTRNSRATTVGIVTCADLSKERGLTQPSQPAFAISLPDRHTECVVIDDPVVDATPVTSKLNWVSPKSADGLWGHRVGGHHREVWLSFRDGSKVSDTLHLALLCDMPLQPAATHQPGFYYKYALSTLCMSVEFKKRPDPTTEWVMVRSNSHQVSNGRYDVNIQVYDDRGDLLALSNHIVYVTEIRAKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2I5</accession>
    <name>A0A5N6U2I5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_137535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2I5"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF60">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN (TRI7), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8152730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="452" mass="51224" checksum="4DDC4CE3273A77FD" modified="2020-04-22" version="1">MSIPPRDVAIIVLASYVPAAILGLVGFPRLVEEFYIANGLTLMILSHAIPIFVLAFAAPSSPVRLMVLPFAAIASVMYHKLAPEYFSSRNQAGGMDGPFMLMFLTVVNVFGIQQLYRDDRGVERNGRQASAESKKEIDQSPGESSGSNCDPWARLKWALHVMFSYRGIGTSRQVPNVPSFGLQVPSRSQFVGDQIVACIVEYLVLDLLTNLRLAPLEAFAPERANLFLAPRFWTVPILSLRLIRSFLFWVDRYITVRFIYDFTSIFGVGCGFTDPKDWPPYFGNISEAWTLRRFWATFWHSGLRLPLASNINFIVYDVIRLRRRSLEARTLATLLTFGLSGAIHYYVDEATGIPRSDNMVIRFFLLQAIGITLEDQAQKLYQQLANPRDETPSDPKAKKNQPTETWHRIVGYIWVILWTQWTMAPYAYSFDRNPVDPTFPISAVQGLKKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2R3</accession>
    <name>A0A5N6U2R3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_137349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2R3"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="560" mass="61644" checksum="1BE6B170F4B9670D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U321</accession>
    <name>A0A5N6U321_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prokaryotic phospholipase A2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_47979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8152986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U321"/>
    <dbReference type="OrthoDB" id="5120271at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024953446" evidence="1">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="289" mass="32545" checksum="EEBF149A815F8135" modified="2020-04-22" version="1">MKLILLTAYLLAGLVTAHPTSENELRSLDPRTDQCSEKAVNNLVFKVTIDSFQKARNASYPSGCDFSSDSCSMSPDTPRGYDFTASCQRHDFAYRNMKNQGRFTKKMKKQIDKQFRHDLRTYCEGEEKLRKDFECKRIADIYYLGVRAYGKGTDKLDEVKELKDAISISRRGVGFGFEADHTGFDMNAHANHEFSQYDDDGYEQDGFLESTAKTVVKSMANAAVQDMFDKRGVGLEVDADHDGVKPEANAGDHKVSVEFDFDADIDNQEIPPIADEPVTLVNLEDLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3T2</accession>
    <name>A0A5N6U3T2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3T2"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71686" checksum="B366012AB5D8474E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U468</accession>
    <name>A0A5N6U468_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pkr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_28051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742039">
        <property type="protein sequence ID" value="KAE8153433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U468"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="175" mass="18957" checksum="895F908F40FBC48C" modified="2020-04-22" version="1">MGSFVEELWGSVFTPGPTPTLLVATNVTFAALQVVLFMLLLATYSIHFLILSVLSGSLWYSINWFARELQVVQAQEAEKKEAEVPTEEKAKSDSFRKTPGALDSTESDTETESLMERKVSAASGPTPQPTPAAAATLQPPDQQGEVRKRLSVSGESSGYQSTDSEWEKVDDNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4D0</accession>
    <name>A0A5N6U4D0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_149263</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 16"/>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4D0"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000640">
        <property type="entry name" value="DNA repair protein Nse1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.220:FF:000003">
        <property type="entry name" value="Putative DNA repair protein Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="238"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8153497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="335" mass="36988" checksum="53804963A403E61F" modified="2020-04-22" version="1">MANGYEDGGYDDSNRAFLQAFMARSTMTFAEARPVLAAIYSVHEGEPVSPEDVTQDDFASYIAAANSKISPFDLEIRSTLRQSPVDHDAPGNQSPERVYALVNTTSDALTQLATTYTADEISFVKRLLDAMFDTNNNRLSEAMVVSSMQATQLAKAPSADRRESTSATQTQGGAANSLTMSQAETVLGQLVDEGWLEKSRKGFYCLSPRGLMELRGWLVATYNDENEDGRRMNKIKFCAACKDIITVGQRCGNRDCSGRLHDHCIRNFFRMQQAEQCPVCKASWPGDRFVGERAITNTERYMQGRRRSGNTQRQSTGASQSQAVSQDIDGEADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Q5</accession>
    <name>A0A5N6U4Q5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_127085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Q5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="62"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8153568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="46338" checksum="16ACE708F6121594" modified="2020-04-22" version="1">MNPIKVLFAKARSQLSKIVKTPSQQVSIDRTKLIPAVEEPDYYQSGGFHPISLGDTFKSDQYTILRKLGYGQYSTVWLAKDTRYQKYAALKILRADCYGGPHDIFEREILSRIQEVSQKSHHEGRSYVSGLLDHFKHTGPNGDHVCLVFDVLGHHLDFQAAKYEDGKLPVKAVKTIVRQLCGVIHTDLKPTNILLELESPNNTISQYLEKVPQRTSQGHGATVPLREVITTPLVSEMVYPQVRIIDFGLASWRENHLSDHIQSLALRAPEVTIGAPWDTGVDIWSLGCLVVEFVQGIVLFSGEASEDGTWTAEDDHLARIIEVLGPLPSHLIRSGKRAAHFFDEEGTLIRIPNLKPTKLERLINGTTKPFLKPSDMPEAEVPIFIEFVQGMLELDPGTRKSASELLQHEWIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U570</accession>
    <name>A0A5N6U570_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_168453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U570"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="296" mass="34172" checksum="DF9D06D4582BD34E" modified="2020-04-22" version="1">MELIERWLYDVPEPPKRTRDRPMKILALGMSRSGTESLSRALRILGYDHVFHGFEMWQNTPMLWKGWTQFGRRKWGQSRDTHGTSGLTRADFDSFFGHCEAITDQPGAIFAPELIAAYPEAKVILNHRNVDAWHRSFCTVLRPLTTGLFYHVLPYFNANLYWEAQYLSECVKSFYHGSWERHGKWVYEQHNATIRGMVPADRLLEWTVEDGWEPLCRFLEKEVPPDEFPSGNTVDNTHDSHDNDLLKCVVSARRNLSLCIACVGVLVAVGLGRRVNWGQWIRAVDVRASINSFIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U581</accession>
    <name>A0A5N6U581_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U581"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="36909" checksum="91C5873753B29998" modified="2020-04-22" version="1">MIGDDSHPANLEVDSDFDDQQSVDSDLTSIASSIYNYVYENGRTYRSYRPGTYILPNDEKEQERLDILHHVFRLILDGGLCQTVLEDPQKVLDVGTGTGIWAIEVADDHPSAEVIGVDLSPIQPGWVLPNVHFVIDDVSEEWAFPHDSFDFIHVRCLAGTLADWPYFLKQCFRHLKPGGKIESSECRTHLLCDDGSYPKDSYTHKWVNEFNRIAQKNGRPFDLFPQFKGLLQEASFTNICTFEKPCPLGTWPKDPRLKEICRYFRAQFLWGAADGYSMALFTRFGGWTPVEVEVLLAQVRKEIKGNNMHVYALCSFVTAEKPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5H7</accession>
    <name>A0A5N6U5H7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative florfenicol exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_136587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5H7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="54496" checksum="4C608566464EB5C3" modified="2020-04-22" version="1">MTREDEPTETTRLLPPESREADENAIQNADDLHVDWESPSDPSNPKNWPSAQKWLCAMLVSIYSLIAPTAAAMVVPAMPALARDLHITSSGMLQMTLSAFVLGWGTGPLILGPLSEVFGRAPLLHVGQLGFMLINVMCALVRNPYVFLFLRFVSGLFGSGPTALGAGVLSDLWVSDERGVSLAIYTIMPLLGPTAGPLLGGYIIQYYDWKYIFYLCSSLTGFFLVFGIFLLPETFGPMILHRKRLAKLKKMNALPRDSAWGQRLKSLIGKSLSRPFVLLGTQPIIQVLAVYFGFLFGLYQLTISTFHSLWKDVYGESDMVSSLNYISMTVGLIVGCEIAGPLNDKIYRTLKRRNNNVDLPEYRIWLMLPAATLVPLGMIWFGWSAAAKSHWIMPNLGMGVAAVGLVMGFQCMQAYVMDAYPIYAASAMGALTVLRSLAGFVMPIFAPALNRSLGYGWASTLLAVLAAIVGGVTPGVLYWKGATLRAQSPYAAGDVKVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5I8</accession>
    <name>A0A5N6U5I8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_148655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5I8"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
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            <end position="103"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
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        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
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            <end position="411"/>
        </location>
    </feature>
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            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
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            <end position="568"/>
        </location>
    </feature>
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        <location>
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            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="638"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="668" mass="73283" checksum="657596219DFA2FF6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5Q5</accession>
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        <submittedName>
            <fullName evidence="8">Pre-mRNA processing factor 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_148656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="588" mass="65032" checksum="4A7108D157172E9B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5Y4</accession>
    <name>A0A5N6U5Y4_ASPAV</name>
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        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_148476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5Y4"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="95"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="46"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8154016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="413" mass="44613" checksum="4EFA1CEEFD48AE05" modified="2020-04-22" version="1">MATHMPLRLSIRTQDHEDPVTSVPPSTVMHGLTPPVTPTMGDISPSCGSETSISSRSSSFVSEDGSKPRDLYQKDLHPLRPLQYSDDLEYLYDPKGRPIEYGRGVWSVVHKASSRPSSKTPLMTPPSSPAAGGKLVAVKSPARRDAHAVLDAEALALTRLNKIRGADHHIVPFHGYIPGSHSIVMSAIPLSLSTYIEEKADIAQKHKTTRTMFDPVGGMAQWHGLAKKLITGLNWLHTEAQIIHGDIKPHNILLKSRPSNTDLECDGFPYEPIFADFSSAHNITGSSMSAEKATGTSLTALTPPFAAPELLSISSLTSPDSRPTTATEVFSLAVTLLAAATGDLLLYPGASNMQRLAMAREGHRVIEFARSGPNGSRVPRNGAVEQVVKPAILKDPSQRIRPDEWVELVNSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U637</accession>
    <name>A0A5N6U637_ASPAV</name>
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        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_148470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8154010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:respiratory chain complex I"/>
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    </dbReference>
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        <property type="entry name" value="GRIM-19"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
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    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
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            <dbReference type="EMBL" id="KAE8154010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="119" mass="13940" checksum="3DC71AA84A2DE79E" modified="2020-04-22" version="1">MPQDMPPAGGYGPVQYKRNVPARGFRPIYYLVGMHLAMAYGYYKLFYGIREQNELAREKIWGRLHVLPLLQAEEDRDQVRRHFADKAREQALLGSETKVYNTERFVRPTFVYTPSKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U681</accession>
    <name>A0A5N6U681_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_167764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U681"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="548" mass="58638" checksum="2190C1648F975457" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6M0</accession>
    <name>A0A5N6U6M0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_126980</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6M0"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8153771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="309" mass="33499" checksum="0839B822B792AA4F" modified="2020-04-22" version="1">MSALSSENITGAYIPSALLVVGAAVLKSEWTPYAVAVAAVLVGAKLAGGSGKARKVLNPTEFQNFVLTEKNEISHNVAIYRFALPRPTDILGLPIGQHISLAATIEGQPKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLKIGDNMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMLQIIKAIIRNRPRNGGNDTTQIDLIFANVNPDDILLKDELEQLAKEDDGFRIYYVLNNPPEPWTGGVGFVTPDMIKERLPAPAQDIKILLCGPPPMISAMKKATESLGYTKARPVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6U4</accession>
    <name>A0A5N6U6U4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_148174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6U4"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="644" mass="72779" checksum="68A5BF601EBEEA55" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6W0</accession>
    <name>A0A5N6U6W0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_136074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6W0"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF11">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="460" mass="50584" checksum="18724ADF6174ABD4" modified="2020-04-22" version="1">MSRQSSRAQQACLRCRTQKRKCDKQLPGCALLSRACRYAVQNGSVNPAAQQPSVSVPVPELTQLTPESISSTIKAQVITAIGGERSVRQAAAVYFQTIQSWLPIIDERLYYDRLPSSLKDTPEFCLLTLCMFLLGTVPVDHELSLRMRSLYTLAKTFVALIDATGENTLDLLQARLLLTIFEVGHGMYPAAYMSMGANVRAAVALGANGTCDRQLCAMFNSAERADEARCTWRGIVIADRYVALESGKGSLIHKDVMPMNAAESQGSIRTICPTTRAETAIHEARPSIPSIDQVLTHVHDPTQHQDFNNNEALQLLKTLNAFEATLQAHPALNTLCDSTTALWRSAALTFMKFGCHVKQPDGEYCNALALTRLVELVKDLVSSCVMLVSGVSPFHPGALPVFVIQPVYKAALLLRGDLMNNPRFQNKNAGRDLENSLQCMGGRWLAARRYLLDLGGRDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Y2</accession>
    <name>A0A5N6U6Y2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_136064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Y2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031598062" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="562" mass="61444" checksum="629D97B8EE049D4C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U737</accession>
    <name>A0A5N6U737_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_10012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U737"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="210" mass="24069" checksum="8E881CA5A316C971" modified="2020-04-22" version="1">MSNPPASDTEFRKTWNREEYAQKAAAEEAKRKEESKARYEAKLLGKKWHAPVDYSALEATTSRKQRLDVGSMVGKTTIVSSGAAVGKRGRGAGFYCSDCDLTFKDNLQLVEHLNSKQHLIATGQSGEVTRASVADVRERLRMLAHRKRVREEEERRAWQLDLGVRLKEREEQDAKEREEKRRKRNEKRRKGGDGIKQEEDSWEGRLGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7H2</accession>
    <name>A0A5N6U7H2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_109899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7H2"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF32">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="55157" checksum="B005FFEAD726732F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7K5</accession>
    <name>A0A5N6U7K5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7K5"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="437" mass="49624" checksum="9ED0C6A427F7ECD8" modified="2020-04-22" version="1">MFDLDDVKLRYNKLKGIEDSKEKIIEELFSHVKELRRELKESRDEVDNFKHLTGLFKDKSNRDREALEVKSREQARLNYVSVLVDGDCMNFQDSLVQSGYDGGQKAVRLLKKAVEDHLFDLDPEANPSIQYRIRVYANVTGLMKTYRDTNIVPAEETMEAFIQGFNMENGFCDFVDAGTGKECSDVKLRALFEQDIIDVHCQRILFCASADNGYARVLGPYRESDRISLVEGPPFAREMKELSSNFATAVFPDVFRSNKIPSRRVSFSNSYITPPSTPAQNYASAAKAAVSRSQSTSERNRSPSPLTSARASPTPPRMSVCRNSKGQRVDPPLRYSSKDNVDVLKSQKLCNPFHIVGYCPYGDNCNHGHEPRLKPHQIEDLRYIARLRVCPRGIWCDDENCVCGHRCPRENCHGPGYMGCKFPKVMHWVDSNIVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7T5</accession>
    <name>A0A5N6U7T5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_147243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7T5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="66" mass="7036" checksum="C717441FDF6FB743" modified="2020-04-22" version="1">MVSRLSGHLSKTLMYNCAVQSLAGCIPTGRGGTRTLATVRPSGHSLDHADRPVKGPVHRTAAYMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U870</accession>
    <name>A0A5N6U870_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U870"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024973433" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="157" mass="17310" checksum="80EBD935627724B4" modified="2020-04-22" version="1">MAFQIYGLFGLLLFVLHLAAMRQGELRPFAGAVGGFDQGFSFIGFRLVTLREAHNYATKGLVYELYDGRQDPARARDDLTLGHGLVLYSSMSKFPVDPDPEILACAVAYRSSIADIADKVLLTVCIMLEMMCTSGTFGETMTRTDERTDASRHSLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8A4</accession>
    <name>A0A5N6U8A4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_126287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8A4"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="613" mass="68041" checksum="A203B8C925264BFB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8C0</accession>
    <name>A0A5N6U8C0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_135528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8C0"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF17">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="127"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8154885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="620" mass="70446" checksum="FA0A104BC3C943CA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8F7</accession>
    <name>A0A5N6U8F7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8F7"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="427" mass="48180" checksum="0263000E9D1FE003" modified="2020-04-22" version="1">MYGLAIAVFLALLIFLRIFSNYTRLQRIPGPLVTGLTGLWSTYERNTPGFGRRLTGLHQQYGKVVRLGPHCVSVSDPTVIFPIRNSRPLEKSIFEYGAPGSVDGFHAIGAQDHSMTTRQTCLGTALQYEGIIDRSANNLIQTIRRHPLLQMTAFLRWFAADFVNHLTTGNTVQHMPAEAVGYQSTTPGNWSILENTLLNSSIARLRRSRDLSIGRLFHKVNQEGHLTPAHHGVSESYDNGQEALRSITTAFAVIFPVLLQHPGIMTKLRNEIDNAFDNGSLSDLPCWQELSRLRYLDAALKETLRTFSNTNHTHEIPVPPEGAIASGHYIPPETIIECHSEALKNDQGVYGENIHIFQPERWLNADVRRRRSMVRNLLPFSIEINRSPTVRVVWLELKKIVVLILLNFQVGFLSLLRYICIFLANVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8W7</accession>
    <name>A0A5N6U8W7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_146912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8W7"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8155054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="34472" checksum="70119604AB32A166" modified="2020-04-22" version="1">MKFFKGARSPSDDRTPVYSSTQRQLPMLHLKDTARNNMIAVIGEFVGTFLFLFFSFAGTQVSNTPKPVDGAPPNTSNLLYSSLSFGFSLMVNVWAFYRVTGGLFNPAVTLALCLVGGLSPIRGVLIFASQIVAGIASAGVVSALFPGDLNVATRLGGGASISQGLFIEMFLTAQLVFVIIMLAVVKHKSTFLAPVGIGLVFFVTEMIGDYYTGGSLNPARSLGPDVINRNFPGYHWIYWVGPLLGSLLGCGFFSLLKMFEYQTVNPGQDFNEWEAKNGPGSWDGSQNRPSVNLSDTTTLDRAHSPTSGMRSHPTNGSEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8X0</accession>
    <name>A0A5N6U8X0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_135400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Constitutive protein of the cell wall. Antigen target of host humoral immune response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cell wall mannoprotein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8X0"/>
    <dbReference type="OrthoDB" id="3485059at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.140:FF:000001">
        <property type="entry name" value="Cell wall serine-threonine-rich galactomannoprotein Mp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF4">
        <property type="entry name" value="CELL WALL GALACTOMANNOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024838787" description="Cell wall mannoprotein 1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8155067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="181" mass="19068" checksum="E0DD0FB1CAFFA4A9" modified="2020-04-22" version="1">MHLYLLPLLATTLLSTATPIQKRDSTVVNAVTAIATQMTTLNETVTSYTGGLLGTGTALKIEFESIKLSHALKDAISTTEATANLTSDESGTVATAFVDLKPKIDSTLDNIVARKPEFDTGLLGIGSLSFVVKWNLQQEKDLAGQLGEAVVGILAEPYASVAPLLNDQIAGAFEKALAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9Q4</accession>
    <name>A0A5N6U9Q4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_82920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9Q4"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="262" mass="29887" checksum="EC460538917865E2" modified="2020-04-22" version="1">MASLSFSKRENSTWELETKLYEFVTEYVQPSSTTIASDAAAKINEWAKESQSANDLENFLWQTWGLVIEIAEQIPCDHPAQERLVHLIQALRKLPPQTVRVWDEDLRLWEDLPLLGPNLREAWNLVPSDKPSPSEVNEWVSLNSFTARLLALGGVPWYNFAIWSLREGLEEECPETAVDCHLAVAREWFRHSGPVLRQQATVAETKEERMLAGGSLYQGPAKLCPERWTFWKERLDQIGRQEGNAGKDAVNVKEIMDQVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UA90</accession>
    <name>A0A5N6UA90_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_135404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UA90"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="266" mass="30807" checksum="893EF07F83CAE976" modified="2020-04-22" version="1">MSLRFFRRLRHRYAPPCLYFFPFSIYSIMVRFTIALALRDKFASRELVRLTYQLVNLHRNENLEEGYLVNVNPKGQVPALTAKSLPAPLTDSLSISYWVCERQPSLIPETHRASIHRLLSQLHCIQGNPQNPAVYDLLARRDITPEHRRALEYKRDCQNKQIESLFDDGGQQRTNKARDLFSDVLLEYDKFNRGGVWIFGDDIGPTVLDAHIVAFIARLIDVQLMEFVPSELLKYAKVVMGLPEWEQVMHGRPTEWDPSLGPVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCS1</accession>
    <name>A0A5N6TCS1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_134900</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742705">
        <property type="protein sequence ID" value="KAE8144175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCS1"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:double-stranded telomeric DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="34"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="195"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8144175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="664" mass="76084" checksum="DEEFFD45F0A095C8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDI9</accession>
    <name>A0A5N6TDI9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_166830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742522">
        <property type="protein sequence ID" value="KAE8144448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="10">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="214" mass="24250" checksum="10D2FEB7A1AE51E8" modified="2020-04-22" version="1">MYGELGNKLVQHAKRTQSLAHLPPYQTELVRTVGREVRDLDRDVAHLLTPFSGSFNPSTEPAVACALLVDHLCMRRNKRCLLAYHRVRTEKLEELCWTGVDVLEQQLPPAEENTHQGPASSQSGNHSSLSPEEEEYFRQYSDMLAAYKGQWTDVDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGVINLTKNSQLFVRQGDVERLIAQGFLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE43</accession>
    <name>A0A5N6TE43_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_166468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742478">
        <property type="protein sequence ID" value="KAE8144602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE43"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="320" mass="34520" checksum="4999F8D3D833420F" modified="2020-04-22" version="1">MPSINGQQVGSTGYGLMRMTWAPELPPQEQCFEAMNTALSRGANFFNAGEIYGTPEYNSMHLLRAYFTKYPEQAGKVVLGVKGGMKQGTLVPDGSEENVRRSVDECLRVLGGVKKIDVFECARVDPTVPVERTVGVLAGLVGEGKIGGIGLSEVDAETVRRAHKVHPIAAVEVELSLFDTHILQDGVARVCAELNIPIVAYSPLGRGILAGAFTSAAALPEGDFRKTLPKFQDEAMQQNIKLLNEVESLAKRKGVAPVQIALAWLLTLSERPGMPTIIPIPGGMTSAKVMQNLDAPRLTEAEMGEIDALLERHEIVGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE65</accession>
    <name>A0A5N6TE65_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_96867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742544">
        <property type="protein sequence ID" value="KAE8144381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE65"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="780" mass="88034" checksum="6530678315601E98" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE94</accession>
    <name>A0A5N6TE94_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742484">
        <property type="protein sequence ID" value="KAE8144570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE94"/>
    <dbReference type="OrthoDB" id="5422613at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="114" mass="13016" checksum="2CF631BFEA583194" modified="2020-04-22" version="1">MSDEVAPEHTALSEAINQASEETLRLILHDLVETCQVTRERLAMFLLVDEFEVRTFARDPPPFGPASSQLDSSRGESSDSERRKQVPRFALCAACEQEYDVTENTIRSCWYHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEI2</accession>
    <name>A0A5N6TEI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_134362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742436">
        <property type="protein sequence ID" value="KAE8144783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEI2"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000201">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742404">
        <property type="protein sequence ID" value="KAE8144987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFA9"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="70" mass="7781" checksum="9BAD2854E12B73B2" modified="2020-04-22" version="1">MKSGRGVELDGTHVTINLFIEYPFAVDPSVSLPSVVLSLDLAVLISSFCHCFSFFLPSVFSTLFVLKFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFM4</accession>
    <name>A0A5N6TFM4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbon catabolite repressor D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_144949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742384">
        <property type="protein sequence ID" value="KAE8145116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFM4"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000018">
        <property type="entry name" value="HECT-type ubiquitin ligase-interacting protein creD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="7">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="601" mass="67202" checksum="7B3356CABF6BE99B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFS7</accession>
    <name>A0A5N6TFS7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_165189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742374">
        <property type="protein sequence ID" value="KAE8145192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFS7"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="191" mass="21596" checksum="C80EB6ECF2F372F8" modified="2020-04-22" version="1">MSATKASRIGEELWKTKVDKVNAELVTLTYGTIVAQLCQDYDSNYQEVNKQLDKMGYNIGMRLIEDFLAKSGVGRCSSFRETADTIAKVGFKVFLNVSPTVTNWTSDNNQFSLVFDENPLADFVELPDDGRAQDELWFSNILCGVLRGALEMVQMQVEAHFVSDILRGDDTTEMRVSLVRYIEDEMPPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGC2</accession>
    <name>A0A5N6TGC2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_71131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742347">
        <property type="protein sequence ID" value="KAE8145424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGC2"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="121" mass="13151" checksum="4DC14BEE5EF37B18" modified="2020-04-22" version="1">MSAIGSLIFCNDCGNLLDESSGDPTKLVVCSICGARNRDIVPKTIVSESKPSAFPSTLRAKRSAVQNLTAADKRTEALTQHTCARCGRKEMYFTTVQLRSADEGSTVFYTCVCGYKETQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGG6</accession>
    <name>A0A5N6TGG6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_133754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742342">
        <property type="protein sequence ID" value="KAE8145475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGG6"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="382" mass="43497" checksum="E933C0F1D6B3C3D4" modified="2020-04-22" version="1">MPETNLEMPKITNPFDQILTDCRHDPREIQDRYETHRSTRNAQFHTKLLSPGFSGWQTDEILYKLATQATKAPVDDEVPFVDPRHNLALFARPPPHLRGLVAEIQASIRDIAPSIWFTPPGNLHMTVMEMASCRPEAEVEPLVTHLQQSGAVPELVDYTLHHRARLVKPMVSYDATAMALSFVPASGEDKYTYHHLRRDLFDRLSVTGLVMKPRYIVPSAHVTIARFTTRDGFTAGADVDHERVAALVETIEQINQKLRHNYWPQEDGKLPVGGEWRVNVPKTRRTYCKSKDCKKHQQHKVTQYKAGKASLYAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKIVLRLECTACKAKKQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH54</accession>
    <name>A0A5N6TH54_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_164671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8145459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="824" mass="92406" checksum="AA10F4E7293C998E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH61</accession>
    <name>A0A5N6TH61_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_164043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742319">
        <property type="protein sequence ID" value="KAE8145714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH61"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="762" mass="84797" checksum="D2C9F5CEE7696FAF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THB1</accession>
    <name>A0A5N6THB1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_163924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742315">
        <property type="protein sequence ID" value="KAE8145764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THB1"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000074">
        <property type="entry name" value="Extracellular developmental signal biosynthesis protein FluG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000013">
        <property type="entry name" value="Related to fluG protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
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    </dbReference>
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            <end position="530"/>
        </location>
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            <begin position="537"/>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="860" mass="96686" checksum="D597EB0B8AE468C8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI07</accession>
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        <submittedName>
            <fullName evidence="8">Velvet factor-domain-containing protein</fullName>
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        <name evidence="8" type="ORF">BDV25DRAFT_144112</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
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    </dbReference>
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        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="257"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="310" mass="33899" checksum="5CD73D4796B4F76F" modified="2020-04-22" version="1">MLTFKLRDVVTHLKYIISDRFTVSPPKSFPGMAESTFLSRSFADQGVKLRIRKEPRTLIKRSVPRPEDYPQPVPPRSPDRSSIQMPANAFGTYPTAGRDYSYFGGPVKRQRTSVDFGNRAMYDTDGRMRQMEAYPQTAAMYANQPGAYPTPIMQGYPTGHPGVPDYAVRRTFTSVSPEMTYGIPQSAQVPQMQDPGAHSRSSQQATMQSLGMVNPPGTPTADSTGAMMPQTYPRPQYPTGQTILPPLQRNRNLAQGANGATARGYFDQSSQAATPILPSQPLATNEADRYGSATGQAAFEHPGSANGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI26</accession>
    <name>A0A5N6TI26_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF663-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_163414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742296">
        <property type="protein sequence ID" value="KAE8145977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI26"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="82"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="792" mass="89498" checksum="F1E840E533F7D2F5" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI90</accession>
    <name>A0A5N6TI90_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_163784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742310">
        <property type="protein sequence ID" value="KAE8145821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI90"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8145821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="541" mass="60231" checksum="3DEF4B7BC661EF6F" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIH9</accession>
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        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_162997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="684" mass="75051" checksum="BC5359DF5EC0215C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIJ1</accession>
    <name>A0A5N6TIJ1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="3">Ras guanyl-nucleotide exchange factor RasGEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_163036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742283">
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12623" checksum="598AAE9504A37104" modified="2020-04-22" version="1">MSLNTQTRQTYRAILRELPRLSLSNPTPLHRRLRDLYRTNQTADEDELRMRLQTADQMAQYARAQRSYVALLDRYNPGMTMDEEERIRLTARRVGWDLPVTPGSSKE</sequence>
</entry>
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            <fullName evidence="2">Protein BFR2</fullName>
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    </protein>
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
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                <person name="Mortensen U.H."/>
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                <person name="Machida M."/>
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                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="356"/>
        </location>
    </feature>
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            <end position="514"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145941.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="548" mass="60314" checksum="7EAE487991C2BA6A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIP4</accession>
    <name>A0A5N6TIP4_ASPAV</name>
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        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_162932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742278">
        <property type="protein sequence ID" value="KAE8146223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIP4"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="605" mass="66345" checksum="920D6803D66B041D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIY9</accession>
    <name>A0A5N6TIY9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_162669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742269">
        <property type="protein sequence ID" value="KAE8146338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIY9"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="354" mass="39232" checksum="A664395A52327FFA" modified="2020-04-22" version="1">MPVKSPFEACIAKPGQGNVVLSLLPPSNPSLTTLTYKYPLKLLTRAPGYVPVSSALSCPVSRPVHLYLLTYGGGLLPGDHIDVSITLEPQTRLVVTTPQGSTKIFKTEPNSSTKGRRPGKLSDKSRQTLDVRVGREAALCYLPDPAVPYKDSRYEQVQTFTIDATTTKDSKRSSLCILDWVTQGRTSRGENWDFHLWRGKNEVWALDESGKKKLLLRDSLILDEEIDEGLLEDGDETLIRNGLIRERTRPHGVVGTLILYGPIYEHLSTFFMDRFTSQPRIGARNWSSSAPAAVESPPNYDSKVTFTAARVRAGFVLVKFGASDSETAKDWLGNILREEGTVINEFGEEALFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJA1</accession>
    <name>A0A5N6TJA1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_162437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="ML742262">
        <property type="protein sequence ID" value="KAE8146433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJA1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="45"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="213" mass="23610" checksum="876F2B8294A20E2C" modified="2020-04-22" version="1">MAFAAPAIGSTLFSRVFRPFSTSSPFFFSLTSESASRNMSDATQQATLAAGCFWGVEHLFRKNFGNGKGVLDAKVGYCGGSTASPSYRAVCTGETGHAEAVQLTFDPSVVSYRTLLEFFYRMHDPTTKDRQGPDVGTQYRSVVFTHGDEQESIAKDVSDKVSQEWYKQPLTTLIVPAGQWWDAEEYHQLYLTKNPTGYECPAHFVRNFPPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJH0</accession>
    <name>A0A5N6TJH0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial inner-membrane-bound regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_132937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742263">
        <property type="protein sequence ID" value="KAE8146420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJH0"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1094" mass="124315" checksum="27148BB6F9705BA4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJH1</accession>
    <name>A0A5N6TJH1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
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        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PspA lactotransferrin-binding region"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="572"/>
        </location>
    </feature>
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            <end position="32"/>
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            <end position="55"/>
        </location>
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            <end position="68"/>
        </location>
    </feature>
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            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
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        </location>
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        </location>
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        <location>
            <begin position="547"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146496.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="70931" checksum="7A8E2709CB7450EB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJT7</accession>
    <name>A0A5N6TJT7_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_162635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
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        </reaction>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_N"/>
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    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
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        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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        </location>
    </feature>
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        <location>
            <position position="254"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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            <dbReference type="EMBL" id="KAE8146379.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="499" mass="53599" checksum="D46924E249CE0719" modified="2020-04-22" version="1">MSSLPLPPRQLFYDGKAQPASSGKTFQSVSPSDATPLAEIQIASHSDIDAAITAADRAFPSWSQTPAIARARILQKASLLLRERNDEIARVESLDSGKAFTETSTVDVVTGADVLEYYANLVGGGGLNGETTQLREDAWVFTKKAPLGVCAGIGAWNYPIQIALWKSAPCLAAGNTMVYKPSEFTPLHAQTLAEIYKEAGLPDGVFNVVYGSGDVGAYLTAHPTIAKVSFTGQVSTGMKVAGSAAGNMKYVTMELGGKSPLVILPDAELENAVDGAMMANFYSTGQVCTNGTRVFVPSSMKAAFEKRLLEKMQYIRPGPLFDEATNFGPLSSALHLEKVSAYIRHGIEEDKATLLYGGLGKPQVPKELEHGFWVRPTIFTDCTDDMRIVKEEIFGPVMSILYYEATEEAVRRANATELGLAAGVFTKDLNLAHRIIDQLQAGITWVNTWGESPAEMAVGGWKNSGVGVENGRKGIEAWVKNKSTLVDMNGSVATVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJU2</accession>
    <name>A0A5N6TJU2_ASPAV</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_48283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742253">
        <property type="protein sequence ID" value="KAE8146585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="371" mass="42090" checksum="F2E0C3C949065BCE" modified="2020-04-22" version="1">MAADSLTIETFTEFAIGMCFLTVRLYARIKYLGIQGLQIEDAFAVLAMVFWTMMTIIIHLLGIFGNNIGLNYETAMQVPESKVPDLVLGSKLAFMNWIWYLCYIWCLKGVLLCLYNKLTEGTFWKRLVHIASGFCLATWLACMLTHICICTPIPRNWQIKPYAGDNCTVRKPNYIVIATLNVLSDLVVLLVPIPVLLKLQIPLPRKLILIFLFSSGIFVIICSILRAYYSLKSLSTLSIALGWADRECFVAAIVASLPGIKPLFRNTRWLGSSNRNRSTDKQSSRYPGSYPQKFRGSSKTYVSSHSRDTDRFELLDHQGRSSAQKKLSTVESQESILPKDERAVQESQQGIKVTRELILEHERPDAVPRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKT2</accession>
    <name>A0A5N6TKT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_43103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742233">
        <property type="protein sequence ID" value="KAE8146956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKT2"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024810593" description="Protein ROT1" evidence="12">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8146956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="232" mass="25629" checksum="23497F5DD82ACB9D" modified="2020-04-22" version="1">MIAGYLSLSLLVTAVSAGTMSDLVGTWTTKSRNVVTGPDFYDPINDKFLEPNLTGISYSFTDDGHYEEAYYRALANPADPNCPKGIMQWQHGKFTVSSDGTLELTPIAVDGRQLISDPCSSSKAEYTRYNQTETFNVSVDPYHGVRRLDMKSYDDSPMHPMYLVYSPPQMLPTTTLNPVSATGKSKRHVSRDTAPSFSMKNLVSKEDMINPDRWLWAGVVATALGGLAVFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKZ7</accession>
    <name>A0A5N6TKZ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_161239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742230">
        <property type="protein sequence ID" value="KAE8147026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKZ7"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8147026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="215" mass="23398" checksum="E087188D17BAB237" modified="2020-04-22" version="1">MPGQPDYYKVLGVSPNATQQEIRTAYKRASLKSHPDRVPADSSERPSRTRKFQEISDAYYTLSDTSRRQEYDAARLAEQGPENDMPPDGAGGFKWSSFGFGTNDRASEQFGSVFEEMLREEGLASDESDTEGRHHVRPTSRFWSIVGGISGGALGFIVANAAGAVAGTVAGNRLGAVRDAKGKSVYDVFLDLPQSDRARLLSELAARVFQSTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL22</accession>
    <name>A0A5N6TL22_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_143342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742241">
        <property type="protein sequence ID" value="KAE8146809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL22"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="341" mass="36727" checksum="45BA1E7A995BADBA" modified="2020-04-22" version="1">MTRIFLTGASGYIGGNVLHLLLEKHPEYEVSVLVRDAAKGAKIAEVYPRVRVVQGELDSLAVVEEEARRADVVVHAAASNHIESAEAVFRGLSDPTREKTGYWIQVSGATLLSAPEIEKGVFGEPSEKIYGDIDNEEDIKSIIRQYSAKRVVDSFILNSPSSPKTAVVVPPIIYGQGQGPIKQRSVQIPELARITLQHKTGYQVGRGLSVWSNVHIADISSIFVALVEKAAAGDDGPYWNENGIYLAENGAISFGDISRRVAEEATKLGLSSTDVKEVDHAEADELSPHAGILLGTNARAKAQRARKVLGWTPTGGSLQEEIAETVRIEAVALGLLSKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL43</accession>
    <name>A0A5N6TL43_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_169415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742228">
        <property type="protein sequence ID" value="KAE8147055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL43"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="36123" checksum="DD20C2441053C4FD" modified="2020-04-22" version="1">MTTRSVLITGVSGYIGGTILSSIREAQGPWTAQLELAALVRSEHQASTVLKLGVKPVMFSSFDETELLEKIAADFDIIIHAGAGWHTPSAKALINGQNRRKTKTNRPEDIYSFEKYRESREAYHQRTTDITVVETGEAVGVTTHIVMAPTIYGQGTGPFNRYSIQLPAVIADAVASGTVSVVEKGDTVWSHVHIRDLAALYVTLLEKICNNVTVPSGRRGIYVCETGEHSHREFSERLARAAHELGALPTADVMEINLKQAGDKLALGSFSRAELSFAANARTKAVIGRKLGWTPLHGEEWESTFRIEVEAFMKNPPAPKEIPQFLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLE0</accession>
    <name>A0A5N6TLE0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_142996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLE0"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="395" mass="44612" checksum="CE16ECC99D1CE8CA" modified="2020-04-22" version="1">MSHTVIYPFDKGPRHPIRPVHYSYDPVDTNSTFLKHPLFDYLVSAAKQDPHLHRTSFSLNPESLGVSWQTLFPACRQSRQWREAENAAQELIDQLFRANLSSTGALCKRWRDLAEVLQVVETAVAGVVYMYPRADTARIRLLSKLHVAMWIHDDVPRVAECHQEAALCTCLCAQDEDESVFDADTSPTCQVLSCILQDILQLDPALGCRVVAGALKWHRTSRTHCDRDQNSPRLTALSDYLQDSIADISEDVTLSMIRFAGMIHLTTEQEECPLLKELVNLWAKHRIIVKDLFSFGTECLEHQVQNSTLINAVQVLQNELDVSLDTAKEVARDIQLDIEQEVYVLYQKILAKAGPTSVEVRYVRALVESLAGNVFYSCTTGRNAMPLVRMSIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLM7</accession>
    <name>A0A5N6TLM7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_36243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLM7"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="419"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="864"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1226" mass="138027" checksum="75C5DCF13E3962D1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLZ5</accession>
    <name>A0A5N6TLZ5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_34724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742211">
        <property type="protein sequence ID" value="KAE8147373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLZ5"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="88" mass="10036" checksum="2474AF1AF35EBCAA" modified="2020-04-22" version="1">MDQQIDVSKLSDADKKELNQILTNEAQKSNIQQTVHHLADVCWTKCITTKISSGRLDHSEETCAQNCVERWMDTNLAVLKHLEALRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM57</accession>
    <name>A0A5N6TM57_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_160373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742208">
        <property type="protein sequence ID" value="KAE8147418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM57"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="11764" checksum="8FA1EBFF5E970A09" modified="2020-04-22" version="1">MAPIERITLFKISSEEDRNRLLEQYKVLAKTATKDGKPYILDAAAGHSFPDPRNKGFTLSVKTKFASLEDMQYYDTECEAHKALKTVAKPMAEEVLSTYFESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMM8</accession>
    <name>A0A5N6TMM8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum-based factor for assembly of V-ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_142641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742202">
        <property type="protein sequence ID" value="KAE8147550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMM8"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="328" mass="36036" checksum="87625133A77A6680" modified="2020-04-22" version="1">MVQLITTTRILSALETIPPTHRKDLSLPDNPSLGNPITHDQLIQLSRHLRLTNNSQETTLNALLTGTKVYVPPPPKKPEPVSVHSSQTSSHDNNIYINIYNISTTTTSKHTNQKDAISKQSPEYLALKARLLAAYEQDAYTKMTSGTSHAQPNPIFASSTPTLAALHDPAQYDDAEETLTPSLVFNIFLSVVITGFSVYFALRSFTTPELLTTAVSSVWRSAGRGGGVSESVRVLVSFLAAVGVGVAEVLIYVIYLGKVERARAKERKLKEKKEIVVREILGAEKSGLMVDGDKEEIWGRGPNGGLRRRVRERWEEDKEKSTDGDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMS7</accession>
    <name>A0A5N6TMS7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD dependent oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742196">
        <property type="protein sequence ID" value="KAE8147672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMS7"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF25">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="427" mass="47524" checksum="0B0A37B7ECD92DA3" modified="2020-04-22" version="1">METDNQRSHRKIASEAPHFIGNDISVSPTPLIRPTSRSHRILVIGGGVTGLATAWTLLDQGYHVTIISREWARYGNEPRLVSQVAGALWELPPGGCGPQAVKEKLGMAQQWALEGLEIYRHLASDPELSLACGVRMKMFTAFHTNNIDEDELKAKKMETIKQSKLEGFSRGIHLFKKYGVNVASHGGLKDAYEHYAPVIDTDVAMAFMMRLVKRKGGHFATDTIHGDILDQEAHLLQIYDADMIVNATGVWAINAASDKSVYPLRGGLLRLINDGTDFPKVQNAMLVSTETKSDGNFHDVAFVVPRNDNILLLGSILHQVSWNLDLTPDCDTVQEMRARCEDLLPFLKNARLDPQYPLAQERRPMRPTHVRVEREQRLTSQGQPSRIVHSYGHCAAGWTLAFGSAREVARLAKKTLGDQATPFYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN34</accession>
    <name>A0A5N6TN34_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742195">
        <property type="protein sequence ID" value="KAE8147697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN34"/>
    <dbReference type="OrthoDB" id="5421971at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="357" mass="40392" checksum="050740E7F8B77DEB" modified="2020-04-22" version="1">MIRPRDPRVRQTINQISHNLETANETAQEGLYTFSHNYVLPCFATVGHCIYACASPCLPSREDQLRRRRRGRAEAVFDFYDDWDNDDTNDGLLGWGTDELDRLLAGSGLTRSGAEQPRRQRKMSYGTRRTRRKSSVLVPDDRNDPTVIPSSSFLGFLERFRWRFGARGLKYRPSASDLQEHPTGLRKHAYEDEPLMEAEEENEGPSSNGKIGRYRSSTQSSRETTNSLSSRGDLIPSDEEEDAVPLDDEFAMALGSRRGTGLESEDQFSDKPSSMRSVSGTFSLASKGSKKKKKKRSSRLRSSQSSYVEVAQDITTPSIVDLQKEEQEAERAEELEIVRKRLAARQLASSRGLEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN47</accession>
    <name>A0A5N6TN47_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">60S ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_142401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742190">
        <property type="protein sequence ID" value="KAE8147792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN47"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16406" checksum="0FA55BACCC15C5A1" modified="2020-04-22" version="1">MYKPPDLSAQLPIRLATTTSTTSPSAESPGVVVSIPSLRIITRRKLRISLWGYNEEGRKGKTRQANRLRYRLDHSGRRSFHIQKSTCANCGYPAAKTRKFNWGEKAKRRKTTGSGRMRHLKEVHRRFKNGFQIGTPKGARGPESA</sequence>
</entry>
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    <name>A0A5N6TNP7_ASPAV</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147986.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="105" mass="11941" checksum="1208D649EC047327" modified="2020-04-22" version="1">MSTYIYHPLPGHTIRMLHVSPGSAETDRIECKLAEHSLADAGKPHHYEALSKEEEEEEEEEEEEEEVVVVVVVILALILGAQKRKTQTMSRKWMESAIGNAWRNS</sequence>
</entry>
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    <name>A0A5N6TPF2_ASPAV</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="411" mass="47121" checksum="D7179D581FB11F29" modified="2020-04-22" version="1">MATNTRFKKEPSQDILEPYLDFNPMKDFLDEGKLNLKSRDRKFTTFLDLKMDHHSDFIHRLREHVQHYGYEWSELLASENERYACAESFVEQHGFNYWGSEASRKKYLLEEAIKDPACLTTYPERRDEIVRTVVILLERKAKTHTRTPEKKSIESYDELQMVNSRRSSGFGSALSDDDTETMNNTPSKGLHTLAHFPQSESRPKREVSERSITVPPDMGNVSFEPRSKRTRTSAPEIRPFSRVLEYDEKEDSAKTYKPASQKATKAATRKNVVPEAAGKQVGATGGKYPDDTKFLVVASSQMGMAPVWVSFQNFPSASAFLEHMANECRVYEWDPATQLFTESSHLQAMQGNLAASVKFEWSGFEIRVRQGKDHDWAVVMEELQKAWKAKELNVDGGSVPCFKIRVMLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPF5</accession>
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            <fullName evidence="2">CRIB domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BDV25DRAFT_20761</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
    <sequence length="800" mass="88132" checksum="8A6BD45F5C53455A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPV6</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
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                <person name="Devries R.P."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0016810">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="YtcJ-like"/>
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        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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            <dbReference type="Pfam" id="PF07969"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="535" mass="57683" checksum="EBA20D1542CF57F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43738" checksum="05F4AB63FB60C9A6" modified="2020-04-22" version="1">MDWVAAGHESGVRDNRPYRMHGDGPDSLARGSQRFPPPLPGNAPPQSLTNTADGAWPQRVLDEMKDMLLLLSSDGTVMYASPSCSSITGYDASDLQKADLARFIHKDDQDVFLEDLNECIVMARPVHCHFRFCAKDQDAFCTLEAYGHPHMKTTNQGNSTGDGIQECIGVFLLCRPYPTKSSQQIDSFLEHKIENVRLAQRIAQLKQGEEEDLAANNQQAYSSDSKADSMSGQNPGSSSGRSNSNQSIALDATASGEENESSDTLTNDDLDVRPYQEGDTDKKRLQTEDMAHIRGIEMMTGLHYGEGERSQGLSTGLLQGRLIHFDMESAKLEQQTRIIQDSERKKRQKGEYMCSDCGTSDSPEWRKGPEGPKTLCNACGLRWAKKEKKRQDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR99</accession>
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    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
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                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR99"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="86" mass="10115" checksum="7F2C81DFE74DD9CF" modified="2020-04-22" version="1" fragment="single">MVLCCDMWLLGLPPFVKPIIPRKLRIVNVKLDLCLVYGCYLWVAMLHLCCPQRSVLNDDIAVLLSYYDRGNIWCSFLENYLRKTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRE2</accession>
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        <recommendedName>
            <fullName evidence="5">DUF1295-domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">BDV25DRAFT_157732</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42319" checksum="425E5E1122435FA0" modified="2020-04-22" version="1">MALPLPEVQSVVDCASFEHTVLPFLSQLVTLPERLQVAAAAKDVADLQEIYLSTNPFITALGFSLVLSVCFLIFSEITRNYSQVDRCWPILPAIYNVHFAVWARLSGLQTQTLDTIAAIAVIWSVRLTYNYWRKGGYKIGSEDYRWAYIRSWVNNRFVFFLFNIVFISLTQSILLLLITAPTYNFLVLSQLPTGQSFEIPDLVFSRVAFFFVIIEAFADQQQWYFHCAKHEYLKNARIPDQHKKRFMPEDLERGFVVSGLWSLSRHPNFLAEQAIWLTMYLWNAYRTESYIQWTGIGALIYLMIFQGSTPLTESITASKYPEYRDYQARVGRFIPRFSAKPKYKGGAKKTRKDAKKTDEGEAKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRG9</accession>
    <name>A0A5N6TRG9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_157292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742142">
        <property type="protein sequence ID" value="KAE8148890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRG9"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="481" mass="52268" checksum="05CEE1B1EF1C0948" modified="2020-04-22" version="1">MNPRNYSTATRITATLIVSVLAFAVGAASSIESAVLPQNAAAFHVSEVVASLATGVYLLGFAAGSLVSGPLSEIVGRNAVYIGSLTLFMIFIMASGLAPNIGAQLAFRFLAGIFGCPPLTCAGGTIADLWNPLEKTLYFPLYAILSFGGPVFGPVISSYMGQGTLSWRWTNWIMLIMSGLVMAIILLLQPETYAPLLLKWKAAHLRKATGDERYRSDMDVEHIALFSRIGGACMRQFALTVHEPIILLISLYMTVIYIVLFTFFDGYPYIFQHVHGLGQGLTNVVWVAMYVVIAAAGLWVPVVYIWTKREFESTSTTTTTSTSIDMNTGADAGADAGSGSGSKIHPTRPENRLWFAMLGAPFIPIGLFWMGWTDYSKISIWSPIIASGVFGFGTINVFISSYMYVIDSYDIYAASALGFMTVSRYCAAGGMTVVGIPFYSNMGVQYTLTILACISCLMTPVPYVFWRYGVVIRSWSKFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRH4</accession>
    <name>A0A5N6TRH4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_157230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742140">
        <property type="protein sequence ID" value="KAE8148966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRH4"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="6"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="381" mass="41950" checksum="BF13A4F025338A58" modified="2020-04-22" version="1" fragment="single">MSPLIVDIHTHVYPPAYMQMLRARKSVPYVHDPANNADPRLIILSSDDDPSIPLDQRGRPVDSSYWDINVKLDFMRRHGITTSVISLANPWLDFLEPEEAQTWAERINDDLENTCAKVNQAADPEKTIPLDQKETLFAFGALPLSAPSADIVVNEVKRLKTLPHLRGVIMGTSGLGKGLDDVKLDPVWQALQDTESLLFLHPHYGLPDEAFGGSEAANRYGHVLPLALGFPLETTIAVARMLLSGVFDRFPRLKILLAHSGGTLPFLAGRIESCILHERKFIANGGDVQGPQRSIWDVLKTNMYLDAVVYGTAGLKAAMTASGTDRLLFGTDHPFFPPLGDKEEEWPSVTTNYKAIHAAFDKDDDTVAEVLGGNAARILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRR0</accession>
    <name>A0A5N6TRR0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Steroid monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_168091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742137">
        <property type="protein sequence ID" value="KAE8149048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRR0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
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        </source>
    </evidence>
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</entry>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
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                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
        </source>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33591" checksum="11FA7BD590E42402" modified="2020-04-22" version="1">MDQPEAFPPGYKPSTHIAELPATAPIQDILSVIDRDGGVIVNGLVCEEDLASVEREIAKYTHNDREDDDGFFKGLVPQETVLIGGLVGKSDTLARVCEHPVLEALRKEILTDHGTRRVEGYDLPYHIDPLLSVSLSFRVGYGAPRQLLHRDNGTHLIEHESKPYRLNQAAQLGCLIAGVETTQANGATMFIPGSHRWDDQREPRLDEVTFAEMKPGAALIFLASCWHGAGHNSVPGVTRILHGLFFVRGTMRTQENQFLAIPRSKALTMSATMLNLLGYRQPTAALGMVENGDPMLNLAAVLAAANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N6TRW8_ASPAV</name>
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        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">BDV25DRAFT_141330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742142">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="775" mass="85610" checksum="8E2C5BEA9FFE7198" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS36</accession>
    <name>A0A5N6TS36_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742140">
        <property type="protein sequence ID" value="KAE8148969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS36"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="58" mass="6659" checksum="C9FAB0FAF022AE5E" modified="2020-04-22" version="1">MGPSPFSSFFSTDLSFFAPNRRGCYRDRYYVGLWAVILVICEELLAFSLVIGYDTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSA1</accession>
    <name>A0A5N6TSA1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSA1"/>
    <dbReference type="OrthoDB" id="4185962at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="546" mass="59452" checksum="F6AA65DDD8693570" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSM5</accession>
    <name>A0A5N6TSM5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_130458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSM5"/>
    <dbReference type="OrthoDB" id="4499526at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48623" checksum="5E267AD6014551C1" modified="2020-04-22" version="1">MTVSKESGFFDGPVALDGKEYGLYSWELLEDHPLRSYPRDCFPGLAVYVSGYLAALKKRWSESVFPLVCLFLMFMVVIQFLATLPYGLTYILLRSGFGEQKGLAQWPVEFHGERSACVLQNPRASDTIQHVLEAGCSGVKVDVTLKENDFVLNGSVHYKPQDRLHNVYLDSLLEKLDARDSAVGHWASTGHDSPSGLFDEDPARSFLLFLQIHTTIRTAWPRLIAQLRPFKEKGYLSYRNGTQVVARPVTIVLTGLDESDFEGLAGPSDDSIMDNVMFDTSLEQLLMEDHGSALRISASAHGSKRSGAVRSGRDLKETQEQYRFFSYQTQTATADFTRSIGLPGRGGRYTQQQIDRVRAQVRAAHRRGLRARYEGISCYPPSLRRMIARILVHEGADIVEIDEAGCDLPWWRRFIMIGGTRCLRQKEESSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT72</accession>
    <name>A0A5N6TT72_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ceramide-binding protein SVF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ceramide-binding protein svf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Survival factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_156597</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742127">
        <property type="protein sequence ID" value="KAE8149319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT72"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.370.10:FF:000001">
        <property type="entry name" value="Survival factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="17">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="18">
        <location>
            <begin position="215"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8149319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="378" mass="42187" checksum="68B24EDB4BCA70B9" modified="2020-04-22" version="1">MNWLKSTLASVAGTQEPIYGPEAIRSVAQQAQEVPYRELTKDDLRWRAYQYTNVETKTFYIMADNGTLVFVQIIYSNIVGIHTTAQFNAKIFNVNGDAPHKWYSDPLSNFMFDESMLSFGADNLTLTLNEEGNAYELKSAVNEDCSVNITFNRSSPGFIIGKDGTSYFGTDPENPWGSMSHAFWPRCAVEGTIATKEQTYHLKGRGMFIHGLQGMKPHHAAARWNFVNFQTPSYTAVMMEFTTPPSYGSTVVNVGGIVKDGEIVYAGTTNTATHTEAAQDQDSDWPEPKSIKWVWQGKSKDEKELHAELEGPLGKRLDRIDVMAEVPGFIKTIAGSVAGTRPYIFQYAPREKLTLKLKIGDNETTEEGTMFSESTFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTX6</accession>
    <name>A0A5N6TTX6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_172671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTX6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8149757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="502" mass="55367" checksum="9DC51934EE9F70D7" modified="2020-04-22" version="1">MSSTPALEAGGSSSDGVNISRVLRKVDMRLIPLLFITYMFNFMDKAILSSASVFGLIEDTHLVGQQYSWVSSIFYFGYFFWEGPTNYLIPRLPVAKYMAFNTFFWGAVVALTAACVNYGGLLALRFLLGVAEATITPAFMFITTTWYTRDEIPFRTGIWFSGNSIGGLIASLLAYGVGHIEQPLRPWMWMFIILGVATFLWGFVLFTVLPDSISSATFLTPAERELMAQRAMIAGTGRTEQTDWKWDHVVECLQDPKTWHLFAIAILTQIPNGGTQNFGNLVIKSFGFTSLESTLINIPTSIISAATITVTGWLAGRFRQMNCILIVCIVALSITGSALIYSRAHHVSLGAQLFGYFLLATGPGALPLTMSLVQANYRGVTKKMTMTAMMFVAYCAGNIAGPQLFRASEAPTYQTSFRAILICYIIAGAMAISLRVYLQLLNAKRDRTEGVQGDAGLSGVVGGKAIEQGKRDVSELVRSVDLRPEDYDDVTDWKTIGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUA8</accession>
    <name>A0A5N6TUA8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_123457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742115">
        <property type="protein sequence ID" value="KAE8149699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUA8"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="240" mass="26793" checksum="0FF2E5915FE098BE" modified="2020-04-22" version="1">MIPIMDTRNGHFSLRGQFSSTLRSRAIWRIIEPVLTALVVSLEEAELRQCDFVLYSLHRSLPLRVLLLGPSSIDSKFEPETVSRLTQFYHSISNSQNHAVVFLCSEDAFNRASGKYSLDGLLALQVLMAEVLPSLVPIIPVSDSSCFLSCMEQYFDNLIDIPQQNPTLSESITVLSHATAGSPNVLCEQDTNILSDLFPSMRTLSQATRTIEGREVLVDYLGEKKAEPIIGFWGDDVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUQ7</accession>
    <name>A0A5N6TUQ7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_140158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUQ7"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="2">
        <location>
            <begin position="300"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="464" mass="51543" checksum="2D3D8F8FFFAD658C" modified="2020-04-22" version="1">MTSLLRFLRTALKHHHNYLHNLNPNPTPIYVIGNPSADLDSIISAIIYAYHASTNTPHIPLINLPNVPSGSELRRLRPEFTKALWLSTHHPAVPVPEEEWDERDPAAFLREHCLTVSDFRSHLASSTTTTTTTSSSSTSTKKDERCITANAVLVDWNALPNLKSGSLDGLEGVRFHVLGCIDHHVDEGVLAPDSHPRIIEKSGSCASLVILALQDKGLWNQQAKHHANHDDKDSNHEHEHKDKDKDGDTESIQTQLSTLASVPILIDTANLTSTDKTTPHDTSAIDRLAPHLRIPRSDLYATVQKTKEESLDLLTLPEMLDRDYKQWSEVGKTTKIEIGFCSMVRPVSWLVEKVGSPREFLNGVCDFSVERALDVVVVMTAFSEGGRFCRELFVVARGDVARQAVGAFVECNSEGLGLKGWEGRGCEALNGDEGVWRRVWVQEDLSKSRKQVAPLMREAVTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUS9</accession>
    <name>A0A5N6TUS9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742102">
        <property type="protein sequence ID" value="KAE8150126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUS9"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF11">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="26684" checksum="C040F408CFC8E47E" modified="2020-04-22" version="1">MSQFKPFQSKRLAYRAVEPNAADYDFIKYLQTVSQSRANTSLTLLKPRPQNDPVDGYLNYLVKECLLAVIILRNDNDTATDTFSWIPIGVISLKGDSPECSHHRGGVLSVEIAPPYQNQGHGSEAIEWMLDWGFQKAGLHRISLQAFSYNEGAGRLYERLGFRMEGRQREAVWFDGAWHDMLFFGMLEGEWREEVAEWGGSSVVTQMPRIGLTAHKALQKPLPAGQAGSSVASSVFGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV61</accession>
    <name>A0A5N6TV61_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_154759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV61"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="59960" checksum="1C383B534871B206" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVM4</accession>
    <name>A0A5N6TVM4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_154407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742094">
        <property type="protein sequence ID" value="KAE8150433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVM4"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="27604" checksum="641E7F0C7207C263" modified="2020-04-22" version="1">MSDFTEKNRQVFEKMARTYKAGFEKSIEMICRQVQKRRLWASDTWIDTEAGQGKDVKMLEYACGPGHVSAVLAPFVTKVSGVDLSDGMINEYNLTASEVGISDKMVGRKGDLLADAVPEEFSGPDYTDLDVVFVSMALHHFEKPDLAMKRLGDRLRKDGVFLVIDILPEGHHDHNPHEMHKEFQETKDTIKTHGFTLEDMRKLYEDAGLGVNFDFQVIDKPLEFQRNGKTFAKTIFIAKGQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW48</accession>
    <name>A0A5N6TW48_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Integral membrane protein DUF92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_129445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW48"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="117"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8150603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="694" mass="75511" checksum="B9679F40603DB500" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWA7</accession>
    <name>A0A5N6TWA7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742088">
        <property type="protein sequence ID" value="KAE8150665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWA7"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="239" mass="27073" checksum="2996CC1C85DED89C" modified="2020-04-22" version="1">MNSINSKNLPNSPWGEGLVKLTTLELNLADSPRDSSEFQEIEELLAILLSSRIPGPKLLRTQLDSNEFSVAIGIGGQARVQGPSQSFIQKLERCEYYLEDTLLQSATYLKRCVVKQIHTKETRRTGFHQVGFALREVKLLCHPRLADSRVVKLQGWGLCLDSLERSFSTPRLPFLILERADYNLAAALRQERSQFNFNHLRSIAEDVGLGLSDIHKANICHGDLKLENILLFREQDKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWH7</accession>
    <name>A0A5N6TWH7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWH7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="530"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="633" mass="71670" checksum="FA486F60DC706A7D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWY4</accession>
    <name>A0A5N6TWY4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 2-deoxyglucose-6-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_139489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742085">
        <property type="protein sequence ID" value="KAE8150807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWY4"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="228" mass="24412" checksum="039A6E07346319F1" modified="2020-04-22" version="1">MTHSFAGILFDFDGTIIDSTEAITKNWQRIGADLGIDPQTILQTSHGRRSIDVLTDLDPSKANWTYVSDMERRIPYLVDTPPIEIPGARALLEKLGSLQTHYAIVTSGTKALLESWLDVLDLPRPHDVTVAEDVEVGKPHPEGYANAKARLLGSVSGGGCRDVLVVEDAPAGVRAGKAAGCFVLAVRTTHGVEELKQAGADWVVPDLRAVEVAKGDGGVVVQLTNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXB4</accession>
    <name>A0A5N6TXB4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_153446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXB4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="146" mass="16420" checksum="77328FBDA900927B" modified="2020-04-22" version="1">MTCKECLKYPVNGLTNDSFAESTELAPIRSGPELRSHLSYLISSIGIPVLTCWWLLFLFSFPPFSYMLMIIYFHISNYKEKKGVACSAEWQISIVIVSSICRENTNTAGVTSPDEPYHVQLSRSIEIGLPRVFSWGGCVVVFKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXF6</accession>
    <name>A0A5N6TXF6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_139225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXF6"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="77373" checksum="5C70AE967BB68DAA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYG6</accession>
    <name>A0A5N6TYG6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_128758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYG6"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF229">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="504" mass="57397" checksum="4B0DEDDACEB59C8A" modified="2020-04-22" version="1">MDYTTFLQALVSSLLCYWVGWILYARWLHPLSKFPGPPLAAISRIWTVLHVLRGKAQDEQKALHQKYGPIVRIAPDELAISDPRAVKAIYGVNSGFKKTDFYLPFRSPFARYPDHFTATDEKSHASRRKIVHHIYSLTSILQAEEYVDKCTDLFLQCLGEMADAQTSVDLLKWARMYAYDVVGEFYFGQMFGFLKNKDDHIGYLSSTDSLIPVMTLSAVMPSYVRSIFMLGGFMFSRMRKAVGAFDVLTKAADLAVENRRHLFEKGDVSQRKPDLLTRAFEIYYRRGVELDFQLIDLKMEAFGAFFGGSDTSAIAISGTMYHIIRNEQAYRTLVEEIDQATRDGKLSMPHLMYNEAVKLPYLDACIKEGMRIHPSVGLTMPRHTPAEGAHVAGYWVPGNTRIGINPAVLQKDTSVFGDDAEVFRPDRWLETNAHQLNQYILQFGGGSRTCMGKHMALCELYKIIPEILRSFHLSLESSDTLKTSAFWFYKPASVHVRVRRRSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYG8</accession>
    <name>A0A5N6TYG8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_153114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYG8"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="207" mass="22770" checksum="8878D43F0AC09EB7" modified="2020-04-22" version="1">MATITRATRIRNPALFICDIQEKFRPVIHEFSKLIPTTTKLLRATAPLNIPIYITTQNRSKLGPTIPELTPHLSASNLIADIDKTLFSMITPEIDALLPNTRTGEQALDVLIVGIETHICVTQTTLDLLERGHRVYVIVDGVSSVNEGERRVALERLRDAGAVVTSSESVLFEILGDAGHPGFRGVSGLVKEMKEETKGAMEVFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYI0</accession>
    <name>A0A5N6TYI0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_152718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYI0"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="380" mass="41210" checksum="DC3A3F742E3B835C" modified="2020-04-22" version="1">MADPAADAPIDEFAQTRGGDDLFDDEIIPVAAEAHVPPEVQALEENVATLTLDTQSPPTHTEQSSRSRGGEKRGRGRGKGRGRRASHSSGSKRGDGAPRTKSADETAQTEKKSEDSATPEVTEESKKEDATTDPKPSAEANGPRVPAVRGDRSATGGLKKPKLTEEELSRRIAAARENAAKVAAAHARAEADQASFLEREKVAEEKRRQERQHRRVMDNERERNRQRKLHALGGREWDSQKQEEDYNPRGGRGQFRRGMHGGVSGYVRRDFGDSQPGEETNGHIHHNHRGRGRGGRGGRGRNGRGPRDASGPDSTPNDSSTEHKPASTPVINNENEFPALPGSTNKKEGAGETTDSLDKIETSLSPVSAGTTWAEQVENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZG4</accession>
    <name>A0A5N6TZG4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_138563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742065">
        <property type="protein sequence ID" value="KAE8151742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZG4"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="155" mass="17698" checksum="78C6C24D2EFA5BB6" modified="2020-04-22" version="1">MSRDAIQFDPNGLYILISDIGSDIQFHWALYLAATSHHGMMFHMIWSIETGHKWQYQVKSIMGTPNSLNLLVALKIATMEPALHAALTDRLALIPHTAPITCRLWLKRALHDLDEEGYIQLTGKVDEIEQEALTEAAENQPRRIRTSMRSRYCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U031</accession>
    <name>A0A5N6U031_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_152004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="ML742062">
        <property type="protein sequence ID" value="KAE8151935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U031"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000038">
        <property type="entry name" value="Probable 2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="279"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8151935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="427" mass="47361" checksum="69392EF48DEF6F8D" modified="2020-04-22" version="1">MSANSDACPGPTIRFLATWHQDADELSKDSGKRRLSGRIHILGLGNVGSFVAHSLASRPSPPPVTLLLHNSNLYQSWLQRKKCIEITTNELDDIKTGFDVNVFNDQTWHSVPYWNKDGTAENSNNEISTMAQDVDADEALAQSAQNDERIECLVVAVKAPVTVAALKSVKHRLTPDSTVLFLQNGMGTIDEVNDQVFPDPRNRPHYMCGIMSHGLLHRKEPFQVAHTGVGTTILGSIPPINTLSSVDRDIDWAPSTKYLMRTLTLTPPLVAVAETPTALRLYQLEKLAMNSVINPLTAIMGCKNGELLYNYSFTRIMRLLLIEISSVICALPELQGVPGIESRFSPERLRMMVTQLANKTAANNSSMLQDIKSRKQTEIEYMNGYIVRRGEELGIKCMVNYTIKHLVLARSLQAKNKESAAVPIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U097</accession>
    <name>A0A5N6U097_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_151829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U097"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="312" mass="35076" checksum="1FC2857C64C0CC7C" modified="2020-04-22" version="1">MSEPEFHFKFTTVPGYFLQDEPDTNPDTFDYTENFGLIPRSYDSDGEFDPHKSKTQWQRFKHHIDQLNGASGPETQFKLLFLGRHGEGIHNVAEARYGTKLWDCYWSLQDGDETGNWVDARLTELGRSQARTANEAWRKQMGNCIPSPESYYVSPLNRCLETAAITFNEIGLPGTEPFRPLIKELLRETLGLHTCDSRSSKSAIEKEYPLYRFEAGFAEEDPLYEAELRESDSARDARLKVFLGDVFASDVNTVVSMTAHSGAITSILQVVGHRRFALATGGVIPVLVRAERVGGPAPPVVVEPPFRAPRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U107</accession>
    <name>A0A5N6U107_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U107"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="214" mass="24202" checksum="C020C5734E290139" modified="2020-04-22" version="1">MAGKFAKLLRAESESHPMAEYKPVSSRQSMEIDSQHARYSGADESGECDAHGTYYSPDSCRRPRRSIANGCRYDSFAAAWLPPACRNDELIDQFERAGPNPDGSWPYYGDKNKTQVLSLEEVSMLPETGGHFFSTHQWHLVHCAYYWKKMFLALKDGTIIEHRYNNLAHLGHCEMMFLKRDPLDTIVTEAGVSLHSDVIVTVQKHGHGSHSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U111</accession>
    <name>A0A5N6U111_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_128148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742056">
        <property type="protein sequence ID" value="KAE8152254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U111"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024970482" description="Tyrosinase copper-binding domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="252" mass="28192" checksum="2601D1590B8FE46F" modified="2020-04-22" version="1">MFQTRPSSSIKTTIALTAAAVLGLAPTTLTSCKNPGVRKSALGYDERADYINFILCLMNPEMSLRRREHMDPKAAGMSLLLMWRRCSLPMLWALSFPWHCWYTRVHESLLRNGCVVDGAFANLKMKLTTELTRTTDICLTRAFNQTQSGSVLQDIVDICIEINGYWQMWAVGGTIEHVSFSVFDPILDPILVLHHTNLDRLWTQWQFRNTSRLTAMGGPIIAPATLFGEAQSSSLGVGTFLPYFGDHGNTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U260</accession>
    <name>A0A5N6U260_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U260"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="408" mass="44709" checksum="CC2162CBA9EAF6BE" modified="2020-04-22" version="1">MAGEESSRSSHVPAWKKLGLKLKYAKDPLEESVEGQNSEAKKEDNGASSASKEKKSRKNKKRRLEDDNERVEGDGVAVGEEDESRKKKKKKRVSFSAEVMEQEVNGGENDADADAEDEKPQSGGEKKQKKKKEKKSKKDKDQSAAASGAAPHVHETPILSYLSLYYKHRSAWKFQKNRETHLFKHLLSLEQVPTQFNAALLAYLQGLKGEAAKLRLRQIAEEAVKAEIEGDSSDKKEETAADETEEQPTPEKSDYNKAVDAFRACLSEGKQDELNTTESTGLSDNDLLKKLEKRQRAELVLFALNGSLFSYQKPKPIPQKGKGAKGQNQPGKKKKKNRTAFIEISSSSESESSSDSDSDSDDDKGASTKKKQARPSDSSSDPSSSDSDSDAESTSSSDSSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Y9</accession>
    <name>A0A5N6U2Y9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein Atg28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_150724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742050">
        <property type="protein sequence ID" value="KAE8152611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Y9"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51905" checksum="6549F8A30C140C5B" modified="2020-04-22" version="1">MSTHLPQQSNKHLLDLPLRASTYHRDPLIYIDRQSRHIQRNLQVLIDAQSEGLLAGLRGAAQPDGTPTSGSYTPPTDPSSSHALPTVPIRQPVPKKIGLRAAREGIFKSIYDLLKLREEEKEILTVRVLERTDALDEISGYSLKKVGLEEAISKIHSDGGSQSAHDLRQESHTLESEIHETETRLLQMKARHRFVLQELAQMENSVESKLSSYKESLSLLESDIRRFLQNPPVPPQSVTNDATFYTLNPKRRTLDMAQDYWETERLELRKRQKNVDLEIQALEAGGGVWKQVVGEVSSFEKRLKIAMRRAIQSRQSSESNGLFEGGTESDHVRGILEDLKNTTVHVVQYLDVAEEKDWKLLVCCIATELEALREAREMLLDIFPMSDEDAWATPEQEVSDKPRGDNDNNSQSDPLGADNPEPPEDLLRDTYQRTSDVHPRSDDDEDDEPDPAWLLPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U393</accession>
    <name>A0A5N6U393_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U393"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="278" mass="31967" checksum="0B16917F8554ABA7" modified="2020-04-22" version="1">MRPQAKQFYHLRPKLDEILNDTAPVPYTLGAFVAFLSQNHCLEVLEFILEARRYRKTYDWLEQNDNKDEEQQLRLRRQWDRILETYIETGSSHEINVPDDTRQELLDHGQKSEHIPPPNGLDKAVHHMHELLRESILIPFLRNCSGTSHVQPLSVPCLSGTEPVSPDLRATDDCARQRMKSMRLISSSPADMESSDVSEPSTRPISRATDTPDVYRSSSDEARVISGGHDWDVIPDDTGTKIEHARTTPEAEVPPPVARKKKWRRLQSFAKHFRRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3A8</accession>
    <name>A0A5N6U3A8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_170003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3A8"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8152731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="491" mass="53229" checksum="41FDFC77DB89E0E3" modified="2020-04-22" version="1">MSTNTIPGNSQASSVDKLAAELRTTLQAATVLTPDSEGYAESIIRWTDYTEKKAGVVVYPRSAEDISTTVLAARKHGVSFAVAGGKHNSSGACSSEGGLVIDMGKMREVRVDPATKLVRVQGGCIWKDVDDGAYEYKLSAVGGTVNHTGVAGLTLGGGYGWLSGRHGLTIDNVKAVQMVLADGSIITASEDNHPDLFWAVRGAGHSFGVAVEFTFQAHDQKNLVWAGQMAFPIDKLHTVINFANDLIATTNGDSAVFVGLTAPPFTNRKPAVVTSVFHNGVAAEALPIFKPLLDLNPIINSTKERPYNEVNGMMNHAVDYGGRKLSKGAVFRAPLRPEFVSDIILPELERLHATVPGATRSILLFEFLKSDKWCEKSNTDMAFANRGPHLNLLIGPFWDSSEHDNAARSWSHAVAKLAWLEVEREQVEKGPDAAPAPTTEYGNYDHLAASPRQIFASNLERLIEIKQKYDPDNVFDKSYSLIKGAEEVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3D7</accession>
    <name>A0A5N6U3D7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3D7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024938107" evidence="1">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="206" mass="23131" checksum="1D9819A9CDC2F52C" modified="2020-04-22" version="1">MHFTSYLVGLCLPIALAHAAVARVEPIEPKAEPQLPGLRYGHCYIISSIDRGTELGARWYSDPYYRYGDPSHDHTLQVCRSHRDCGRSKGTYLKEDDSWYFLDRRGTAVSGAPAWLGQVSAYVASIDKSQSSDAVQFTFGEPYSPEDYRMCFKPNKPNSGLFINGDYGMQFEGTGKCIDVVFMEAPCRFLPQQKHWVGAGHSEDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3W9</accession>
    <name>A0A5N6U3W9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742040">
        <property type="protein sequence ID" value="KAE8153325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3W9"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="224" mass="25640" checksum="BE768971FE313C5E" modified="2020-04-22" version="1">MYRGGRCRSRRWKGYKRAPDVEDGGEAEREGLVDGQGPGLLGWCERFCGDTSPVKRFAFSRYIGGFDASVVESTLTSALRAINYKGNISVSVSCPNRSFAVYSPHLVNRLRDNSFVYYACVILQLWVITWPVIWALERRYEVVCPVWSFYRQVGSRREYARGRSEEEIADHLVPVVTQAACERRAGARFLTDQDFRILRRHGQDSGERVVVASWERVSGWGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4H0</accession>
    <name>A0A5N6U4H0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_127194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="103"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="478" mass="52677" checksum="4D0844B92D43D98A" modified="2020-04-22" version="1">MHGRDDPEWIAAQKRYMRKLDGIILPMISALYFFEYLDRGNIANAKLYGYSHGHDTNHGGVGPGKGKLSSTQWQLVVMIFYVGLVLFQVPGCIGYRVFPPSKWIAFGVCGWAMTSMLQCTAYNLAGALVCRVFIGVFEGLFGTGIVYYLSLWYHRTEMGMRVFWFLGPTAVAGAFGGLIAFGIGHINSSVPNWKWLFLIEALPCFCLGLFCLYWMPDRPSTNSRFSGLDQEIAEARYKNESFDKAGKIRKKHVIWVFTDWRLYIQVAVYLPTAALLSSISGFLPTIISNLGYSKPTTANLMTVPPYAVAFVVMLAASYSSDRYKERGIHIAVLMIFATIAYGLLATLPESQLKGKYACVCIAVACVYATYPPSHAWAANNFGNETKRAIGMGLYTALGNLGSIAGSFLYPSTDGPQFRKGHFICMGLSIATGVISLGNSLLLGAINKSRDRKYGKPVPGVAVDVTELADKSPMFRFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Q9</accession>
    <name>A0A5N6U4Q9_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Calcium-activated chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_149171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Anoctamin"/>
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        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
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        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF77">
        <property type="entry name" value="MEMBRANE STRESS RESPONSE PROTEIN (IST2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03330)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="141"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="729" mass="83313" checksum="CD10F830F4AAB0C1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U538</accession>
    <name>A0A5N6U538_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="43869" checksum="1FE1139099103875" modified="2020-04-22" version="1">MPKSLRALRRSRKYQIWSARMALQASGSPSRTRLRWPVPPGSPKSEMLASLSSLPSSLAKLLSGKTSTVIRASILRSNTVMSSDKGRHKRRRNGVGYRIKGVGIDEWQPVSAPDIRGSPQIKATHSMLESDHIHAQKGSPQSELNEKEERLQERQGTKRNRQSHAVVPMRDLSDWEIMMIDGLDRKLGWLSSQLLPGRRPFHFAMLPNHWLNTRTWIVYDPASRAPLDVKRRLGDPRFNKPYPKPDLGRKRRCPKVNPKIAHTPHINSWREAVNKNRKASGLKDLVKPVDLFDGSAEDPPGGQFDPACWMLRKPPQAFSLSSRQKETYYEGGAGWQEKLIDWQNVRRGYRVRKLIHEGRANRTRTKEVALSVTRCTNARMHDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U547</accession>
    <name>A0A5N6U547_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U547"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="49"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="903" mass="100572" checksum="12BABF9EC87B1CD7" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U551</accession>
    <name>A0A5N6U551_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_168443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U551"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30078" checksum="0CB7E0CD2B620B8E" modified="2020-04-22" version="1">MTSETGFLPSVLITGCSVGGIGPALAEEFHCRGLHVFATARSREKMAPLEKLSNATLLELDVTSPQSIAAAVEAVTAKTGGKLDYLVNNSGQNIVRPILDTSVEEAKRLFDVNFWGAASMVQAFAPLVIAAKGMIVNLASVSAWYHGPWLSYYAASKAALVAYSDVLTLELKPFGVRVITVVAGTVQTNIFSNYAGRPDSTLPPNSLYMGAAQDVQDWTDGKVVKDAMSPDDFAKRVVGDVLGGGSGTIWRGTGATVSRIVFSIFPSSLLMRFSFWYAGLGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5T9</accession>
    <name>A0A5N6U5T9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_126948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024943494" evidence="4">
        <location>
            <begin position="18"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="791"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8153910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1316" mass="146369" checksum="E0951DEC4E503542" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5V7</accession>
    <name>A0A5N6U5V7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_167990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <end position="513"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="557"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153978.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A5N6U682</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Isbrandt T."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
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        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6K1</accession>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">IBT 18842</strain>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TMEM86B-like"/>
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    </dbReference>
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    <sequence length="263" mass="28521" checksum="F556FC6DD45F457C" modified="2020-04-22" version="1">MPNPLSIPSGAACLLGISLPLLVISEHRSRSHIGTGIFKMLSSTAFLIIPVLSSTKPSPYHSLISTGLTFSLIGDFCLIPSRSDFYHSKTRTTAPKPRTPSLSFHLGILAFAAAHISYIAALLHDSRETLWSMFIIAIVTMLAIAKWLGVVYPPSHASARGNVLDLCIPEQMKPLVSMYAFIIGVMFAAAVSTAPLEFVTPWPYQRTLGAGMFVASDLFVAKDAFGRSCIPQARGWFRIAMGYGLYFWGQAVIAGTICGQYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6V2</accession>
    <name>A0A5N6U6V2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_116485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6V2"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="362" mass="41049" checksum="60BC9433D043BD4C" modified="2020-04-22" version="1">MLSDPAFGCLSRRRGQVILAASVFLLLLFYPFRSTIVPSVATSSSPSHARTLSARTLLTRPLSRDVTTIPKIIHQTWFPAGSNMSERAQVWVQGLREQNPDWEYVLWDDETNRMLVEQHFPWFLEAYNGLPKEILRADVVRNLYMYIFGGMYMDVDTEALRPVAPLFAGHETALAAHEDTLSSAPFPQKSTMQRAFLGRMAHTVDILGSAAVPNGWMASPPGHPFWLLPVLNVLENPEGTGDGSVEGLTGPGALGLMIKKYWDSFKNDSLRQHACKTIQKREPSWRLFCDESENLKGESLKDALVLLPEKQVYPFSWVDDREHADVCEAAWENPTFNPEECKRRIDVEAWPSYFITYCTHSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U713</accession>
    <name>A0A5N6U713_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_121530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U713"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="578" mass="64036" checksum="2328609A6AE73478" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7A0</accession>
    <name>A0A5N6U7A0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_147412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7A0"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF35">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
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            <begin position="1"/>
            <end position="25"/>
        </location>
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            <begin position="26"/>
            <end position="460"/>
        </location>
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            <begin position="437"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8154517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="460" mass="50801" checksum="5623FEA00682D47E" modified="2020-04-22" version="1">MRYFNGRQLCATSLLLLLNAQTALSDLGITVNNDDSYISAAKEVISPMMEFYKQNQTEGIPGKLTDTWYIAGSMFMTLIQYWQASGDDTENKIVSHDLMFQAGENYDYFSSNYSQWLGNDDQMFWGLAAITASEAGFPERDGKPSWTSLARAVFNEQVERWDSTTCGGGLRWQVWPYQAGYGLKNAISNGGLFELSARLARFTKNDTYQDWAEKIWDWSAKSGLMNVKNWNIYDSVSNDDQCKSPDNHQWTYNYGTYLAGAAFLYNHTNGDEKWLKRVNGLLATSLQTFFPKKFGGNTMSEVACEPIMTCDRNQICFKGYLSMWLAFTAILVPSTRDQILPKLQGSVEAISTMCNGQSDGMSNLCGLTWGAGKFDGVKGLEAQMSALGGITANLMLSATQTPKTIDTNPNADEGTVPSSGESDDPSKPKPITTADRAGAWILMVIVSVAITGAVGWLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T9</accession>
    <name>A0A5N6U8T9_ASPAV</name>
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        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_135381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="103"/>
        </location>
    </feature>
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            <begin position="124"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8155043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="517" mass="57151" checksum="11FA72BB0E6B43EF" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8U2</accession>
    <name>A0A5N6U8U2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_135343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8U2"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8155006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="317" mass="33917" checksum="55EF346EABCEB1E6" modified="2020-04-22" version="1">MAALTVTGRVPATRTIVPLTSIFTPAPDCASRWTYIPQDVVSISRGLLLQNAVPSDTPCYPWGYHNTGRAEASMVLSPGYCPMGYTTAKMEAEAQKTTAICCRSNFTYYTERIQYSNGYQDFFAGCVSNLPQSSNIQASGDTRVTGPVTMWAQPITVMLHSTDMTLYTTPTASPIPVPAAIPIPNTSPTASRAEPTLSKLYSSSQTSTTAEPVPIPTSDAPIPTPPPAQEQPGLSAKAKGGIGAAASVALLAMVALVAYWRVLRIKNSLNESVDSTGMTRRISWSYYIWASCPGPLYDQKGQRVKVVRAGPPAELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U928</accession>
    <name>A0A5N6U928_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_146706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U928"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8154929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="648" mass="71452" checksum="AC1FE66BC49B83A6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9I0</accession>
    <name>A0A5N6U9I0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_134993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9I0"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="39130" checksum="39D79F9A3F588A72" modified="2020-04-22" version="1">MSSLIPLKRKSMDDSQACPLLSPHVSNSDPPSRTQSPVGRRVTEDGSIHSIICNNPRRRLYVKPIAWTSEHLQFLGCSFNLQRAPRTKGPIKTPDQVGSRSQRSQHAKRIKLQLGLPSTLTVKKFAAQEILEAYDLRPQGQERLWFQFNHQHVANLPTDGIFASKDTPSILAFVTFETIQSLRQRHVRPSKSATVCLLNMKRKKLKLLEPLNPAEDPYLVAMLIALAQDQRRQQQQKVQDTSTTTDVTSLKKSQQHCECMDQMVPCFAKSFKKVKILAITGVLAKYLYVYTATIPTAFLDKFDEPLRYSPSDPITVTYCRISVIEETSLERLHSLLCTGSCSFCGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9X5</accession>
    <name>A0A5N6U9X5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9X5"/>
    <dbReference type="OrthoDB" id="4449063at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="78" mass="8771" checksum="59C15199C6EBE02D" modified="2020-04-22" version="1" fragment="single">MAPKMRPETDYERWLQHHNPEVEIDPRPLYGPGRHGGFASSHDGSSVVPLLLLFVVLVAVVVAGREIVVTRKRRSDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCX4</accession>
    <name>A0A5N6TCX4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stm1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_167346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742644">
        <property type="protein sequence ID" value="KAE8144225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCX4"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="96"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="284" mass="31193" checksum="A0D712B6242C59BA" modified="2020-04-22" version="1">MADVRSKNLYELLGNDPELDPNRAPEPPAKAVDRPAQRVGKRDTPKEAPQPRPGQNSRRGNNASGNEAAFRDRNAGRNQNREKPTDEREGPRRDRGGRRNDRQSRTGQTDTGKKVNQGWGGQSGDKEWADERAAEKIAKNDETEPQTPAEEAEPVDKSKSLADYLAEKAAQGDLSAKPVRSANEGSKADPKWAKAKEFKRGEDEEYIKGKEEKAKQQRSRKEKNVLDVDMRFVEAPRGNSGPRGRGGRGGRGGRGGRPSNAPPRGERSAPVTVDEKNFPSLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDB8</accession>
    <name>A0A5N6TDB8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_134745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742556">
        <property type="protein sequence ID" value="KAE8144353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDB8"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="241" mass="27128" checksum="30C4C2BB4CB5F960" modified="2020-04-22" version="1">MSSTFYRILRIPGAEYISSCLCPLRNNNIQGDIFAQHSASDQVAEVKMILAPLARRDIAIARCLGLNYEQHAKESNLLVPIYPLHIHKPITPINLPRDAILISAMAQEGEGLDHEYELVIITGELAKNVPERRALDIVLGYIIRNDVSRCEVVTGRLIVLRVNGHWGKWALLGPGIVSTRLIHNLNELHIWTKLNRELVQSMKWTKDMIFGYFLDLFQGTILKLKFSHGAQGVGMGQKPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDD0</accession>
    <name>A0A5N6TDD0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rdx family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742606">
        <property type="protein sequence ID" value="KAE8144266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDD0"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="149" mass="16625" checksum="598512460696D1E2" modified="2020-04-22" version="1">MTTPNPQPQSQQEQEQETKPKITIKYCTQCKWMLRAAYFAQELLSTFSTDLGEVSLIPVTGGIFTVTIYHGEGRSKVQTVLWDRKSNGGFPEVKVLKSLVRNVIDPSRDLGHTDRALRAANVPVQSGDVTRVDSVPVDSGEKKECEECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDG7</accession>
    <name>A0A5N6TDG7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the POA1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84" evidence="4"/>
    <dbReference type="EMBL" id="ML742531">
        <property type="protein sequence ID" value="KAE8144424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDG7"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="484"/>
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        </location>
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        </source>
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</entry>
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    <accession>A0A5N6TDS2</accession>
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        <submittedName>
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    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_145637</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">IBT 18842</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE56</accession>
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        <name evidence="10" type="ORF">BDV25DRAFT_88808</name>
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        <name type="scientific">Aspergillus avenaceus</name>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
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                <person name="Lyhne E.K."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">IBT 18842</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
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    </feature>
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        <location>
            <begin position="251"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="912"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="934"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1050" mass="116008" checksum="0D99A84B5D5625E1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEB9</accession>
    <name>A0A5N6TEB9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW-domain-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_145411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742466">
        <property type="protein sequence ID" value="KAE8144646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEB9"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25414" checksum="CBD39B77BD81CD23" modified="2020-04-22" version="1">MSINWVMLHEHEGFVRLPQESLIYTSPPRTRLSLQPLSSYKGKDKDSLSIQSASGRIYLTNQRVVYIPAQPSTEFQSFSAPLLHIHDTHVSAPLFGPNVWTALVQPVPGGGIPPALPAVQLKVTFKEGGAFDYHNHFERIKERLEQAVENSQESRRGLADVDMSTIHLDELPAYSGPQHDNSNHAQSHPQGSRPDSTSGPEPAEPPPGYEEAQQQSVANELEERLRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEV5</accession>
    <name>A0A5N6TEV5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_145158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742417">
        <property type="protein sequence ID" value="KAE8144898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEV5"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="462" mass="53590" checksum="0D96215CBFB43DC7" modified="2020-04-22" version="1">MEMRMNPDDVTWEQAEETSDNWLAQFLERSILVPIAYFILEQKRGNATEFAILKKGSYNISLRLKYENEATVIRLSQPGAVFFPEEKVVNEVAVMRFIADQTSVPVPFIVHSGTKKESPLELSPFIIMDYVEHETKMYDALNTPGCPVEERGVLDPDIDRDRLEMLYGQLADVLLRLAMPALPRIGSLSQVDDFTWEVTRRPLSMNMNELVRLGGLPRSKLPKADATFSTTSSYLEALVDLNIEHLAHQRNDAVESADDCRRKFVARRLFRKLARDKRLANPSLDKGPFKIWCDDLRPANVLLNYNMQIAGIVDWEFTYSAPPEFSYAPPWWLLIEKPEYWPKGIEDWTRVFDYRLKTFLKVMKQCEDSAIQQGRLIEAQRLSGPMHDSWTSGDFWVIYAVLHSFAFDAIYWQKIDSRFFGPAESPEHAWKERLDLLDESDKDEMERLVARKLEEMETRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEV7</accession>
    <name>A0A5N6TEV7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_86115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742437">
        <property type="protein sequence ID" value="KAE8144780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001090">
        <property type="entry name" value="Vacuolar membrane-associated protein iml1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742372">
        <property type="protein sequence ID" value="KAE8145212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFV1"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="813" mass="90061" checksum="C7A42A893C399E8A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG89</accession>
    <name>A0A5N6TG89_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_164796</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML742351">
        <property type="protein sequence ID" value="KAE8145388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG89"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8145388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="490" mass="54174" checksum="9FB2AF9979ED93CD" modified="2020-04-22" version="1">MVGLGPKRPPSRKGSVQELPQNLLEQIKHFEDVFTVDGAKLKQIVDHFVKELEKGLSVEGGNIPMNVTWVMGFPDGDEQGTFLALDMGGTNLRVCEITLTKEKGAFDITQSKYRMPDELRTGTAEELWEYIADCLQQFIESHHENEKVSKLPLGFTFSYPATQEYIDHGVLQRWTKGFDIDGVEGQDVVPPLETILKKRGLPIKVAALINDTTGTLIASSYTDSDMKIGCIFGTGVNAAYMENCGSVPKLAHKNLPPDMPVAINCEYGAFDNEHVVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIFRLALLDLLETRPGLVFQGQDTSLLRKPYLLDSSFLAAIEEDPYENLQETEELLERKLNIKATQQELEMVRRLAELIGTRAARLSACGVAAICKKKNIESCHVGADGSVFTKYPHFKARGAQALREILDWAPTEKDKVVIMAAEDGSGVGAALIAALTLKRVKAGVTCGIRDMEDMKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGS8</accession>
    <name>A0A5N6TGS8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_67080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742331">
        <property type="protein sequence ID" value="KAE8145584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGS8"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="61"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="412"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8145584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="64008" checksum="2BBD875909411353" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH31</accession>
    <name>A0A5N6TH31_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_170297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742321">
        <property type="protein sequence ID" value="KAE8145684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH31"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29042" checksum="055E0114ABA6FB87" modified="2020-04-22" version="1">MDVQGSGRNYWESSPCMDMHESAPITPVTYLPTKPSLESGYQGNGATDVAGAPDSPFVWDMSPNMEMPTPMPEAPVETEYSQVDLNDWYPRHLACMQYFVDQGQHSIIVQSLAAFINIRLPYQRFSAPVTQFSAPPSMNSRQGVSLETPAHVPLRPYIRRLIATANDTPAVLQAFFGNDWQSGVGCICKQERINYLFTAKSEGWSSTKAAYDILPDEQTPFLRPLREPTEEELRIAESRWSEWLAMEDWMVGPRSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH65</accession>
    <name>A0A5N6TH65_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_66806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742330">
        <property type="protein sequence ID" value="KAE8145590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH65"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21117" checksum="1F21730CECBA0621" modified="2020-04-22" version="1">MARDILKAAKSASNVVAVHKKYTLQSTGIWERLRRLLSIDPNRSTGVPLNAQYRLPTPGALPPLSYDDPVTVPAGDIADNPYWKRDVRRGYPRLSTVNQADAVGLLTVGSRAAPKEGVLQIGKAGEQQLVSVKQQGEERGLAGFFENEKRGTQGVLNANGLPPKPCNLNPSTSKYQLDHEHGYPNVYPCRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH67</accession>
    <name>A0A5N6TH67_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane proteins 14C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_164643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742343">
        <property type="protein sequence ID" value="KAE8145469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH67"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="10560" checksum="E32D562A5451A9C0" modified="2020-04-22" version="1">MSLQTNSAISLALLTSLGGIIGYARTGSVPSIAAGLSVGALYLYSFQRLRTGQAYGDEIGLLASVVLSGSSIPRALKTGKAVPMGLSVVAVYGLVVFGKAVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THL5</accession>
    <name>A0A5N6THL5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_60856</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742306">
        <property type="protein sequence ID" value="KAE8145868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THL5"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024935903" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="275"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8145868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="329" mass="35851" checksum="DB7D5D595A635BFC" modified="2020-04-22" version="1">MYPSAALRPLFVGFLFLLAFPILSDGRHPDNPPGRNAILLSKVHTLTLYANRLTSSRRVAPIPQMTCIGPSKKICDMHTIDVMRCTNVGYDYDEEDVQWTCTASLPQELKLGSTDVVCEGYRNADDKWVLKGSCGVEYRLLLTELGERKFGRVRDDPWPGYTSNNKWRNGLALVGDLIFFGFMLAVAFLILWPMLRACFGLGDPRRGPNGRGVGWGWGGGGGGGGGGGGPYPGPPPPYSSCADSNTSFRSASSGWRPGFWTGAMGGAAAGYEFGRRSNRYNSPATDRRTASFRNRDYNAYDPGEGSSRSRSPQLSSPTTSTGFGSTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6THY3</accession>
    <name>A0A5N6THY3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Soluble NSF attachment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_163415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742296">
        <property type="protein sequence ID" value="KAE8145978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6THY3"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="292" mass="33040" checksum="28C1AFF4671FE9F5" modified="2020-04-22" version="1">MAQDPRVLLQKADKALSSASGGFSFFGGKTEKFENAADLYTQAANAFRVQKQNKEAGLAFEKAASIQSQNLNEPDDAANSLQEAFKVYRKSDPEDATRVLSSAIQHYVLKGNFRRAATQQQYLAEVYEVELGDTKKALEAYEKAAEWFDSDNAEALANKHYLKAADLAALEGDYYKSIEHYERIGRSSISNNLMKWSVKDYFLKAGICHLATNDLVATNRALDNYRDIDTTFISTREHQLLVDLVQSIEQGDQEAFADKLFQFDQLSKLDKWKTTLLLRIKNNIEEQQDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIX8</accession>
    <name>A0A5N6TIX8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_133034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742271">
        <property type="protein sequence ID" value="KAE8146313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIX8"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="121"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8146313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="52287" checksum="092CC7A9A2D0CF61" modified="2020-04-22" version="1">MDVKNLSSNWKKLQETLKKNTVSGATSTTKRKTSDRESQNGVVKKRKTETIEGKTRLEQTRILKKRKRMADEPSNGGDGAHETVAENPLSRKSSTTSIAARPEVKIAKVNEGRSPTAELGKYVAMDCEMVGVGPNPDHDSALARVSIVNFNGEQVYDSFVRPKEMVTDWRTHVSGIAPKHMVEARVLEQVQKDVAQVLEGRILVGHALRNDLDALLLGHPKRDVRDTSKHPPYRKIAGGGSPRLKVLASEFLGLDIQSGAHSSVEDARATMLLYRRDKDEFEREHLKKWPVRVVVEKERGDDEQKKKKKKKKKTHIQRSSGSEDTNLSDNVTANILPCRIHHDGPVESVRQYWKAVPDEQDKNLQTAHFRGRKLRGRRVAIPEGYEGVVALPTDRVIPPTQSGVNDGNDEAVEPVKVLEKQATFNDYVVWGHELIPAADDSFVKGVEEWVKFAEAMHCQSSGENKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ55</accession>
    <name>A0A5N6TJ55_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742274">
        <property type="protein sequence ID" value="KAE8146280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ55"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="72" mass="7284" checksum="417980584C64698B" modified="2020-04-22" version="1" fragment="single">MSTARLPPTPSAPSTGTAASAAQPPVRAITASWVTLCTSMTTTPRWLAPTTAGLASSSPRATARFPPSTMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJX9</accession>
    <name>A0A5N6TJX9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-dependent bile acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_162023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742248">
        <property type="protein sequence ID" value="KAE8146674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1521" mass="168416" checksum="957C5047943817DC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK46</accession>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
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                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
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                <person name="Lubbers R.J."/>
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                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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            <strain evidence="9 10">IBT 18842</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF84">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09170)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="54"/>
            <end position="71"/>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="175"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="485" mass="53726" checksum="825D6C4D4EC93608" modified="2020-04-22" version="1">MATTIPRASFEKKDMGHVEMAPDIEKPSKDTPQYDKFGSFAKVDPKEIALVRKIDLYMMPILWLMYFLNFLDRNAMVNGKINSLSEDLNLHGSQYNTCVSILFVGYLLGQVPSNMLLNRVRPSWYMAGFMMAWAVVSTLTCLVKDYHGMLVCRLVLGIVEAPFYPGALFMISLFYNRKEATARMAVLYTGNMLASAFSGLIAAGVFAGLDGKRGFAGWQWLFLIQGVVTIGVAIAAFFVLPNAPRNTPWLTPEERQLAHSRIARDTTQREEGTSTWVGLREACMDYRTWVFALMCNLHLSANGFKNFMPTVVKTLGFDSTITLVLTCPPYLVATFTSVAVSWSSGHFNERTWHVTVSKALAIAGFALGCGTLNIGARYFAMILFVGATYGVNNINIAWTAATLGQTDEKKAVAIAITNTLGNLASVYTPYLWPDSDAPRFALAMYCSIGFSVGVVILAWVMKFILMRENKKIRAADSGAVNFYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK60</accession>
    <name>A0A5N6TK60_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_169639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742244">
        <property type="protein sequence ID" value="KAE8146743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="9"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="934"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2278"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="934"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1083"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2364" mass="258955" checksum="97085814A848BF28" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL49</accession>
    <name>A0A5N6TL49_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_169555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742241">
        <property type="protein sequence ID" value="KAE8146811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL49"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="444" mass="50750" checksum="3C9CAC766E95A08C" modified="2020-04-22" version="1">MARKRLLYFLTKRSCSPLSNPGNLPRLNVFSTASRTGASKRGIADLHSSLKPRVFPTSGWESIEPSLPVEEESIPTYKPEKFYPVHIGEVFNRRYQVVGKLGYGSSATVWLCRDFLEHCYIALKVYTASTTAFQEIEIYNHLHTLQSTHAGHSCLRQLTEIFQTPSPDGRSVHTCLVHPPLGISLDQLVQLLPDQVMNSVMVRTTIRNILAALDFLHTEAQVIHTDIQPNNILLGIKDNSILAKFEEAEFEAPVPRKTLKDRTVYLSRPLPISYGTPVLCDLGEARIGTDQQHGDIMPDIYRAPEVILDMTWDYKVDLWNVGMVIWDLFERRHLFRAWNPERKLDDGYHLAGMQAVLGRPPREFLARSDRSLQFCDENGEWKGAAPLPDESLEALEGRLQGDEREDFLRFLRRMLCWLPEERATAKELLFDPWLMHGLFKPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLZ8</accession>
    <name>A0A5N6TLZ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_160457</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742210">
        <property type="protein sequence ID" value="KAE8147376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="994"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1173"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8147376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1495" mass="163372" checksum="B29B01C736240FAB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TME0</accession>
    <name>A0A5N6TME0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">BDV25DRAFT_36374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742217">
        <property type="protein sequence ID" value="KAE8147261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TME0"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="438" mass="49365" checksum="2511007D2B6309CA" modified="2020-04-22" version="1">MIMTTAKPTAQITFLSDLTPPSFERTWLTAPHPTLPLVATCSSDKTVRVYSLTKFELLSTISGGHKRSVRTCAWKPYVQGESVLATGSFDATVGIWRRWDGYNRTEESTESWEWNSETPGNNRLINQEEDDEEWRFAVLLDGHDSEVKSVSWSPSGMLLATCARDKSIWLWEDLNDGDNNFETVAVMQEHEGDVKCVAWHPVEECLASASYDDTIRLWREEIDDWGQVSCIRGHAGTVWYVDWEGVANEPSTTAVTGDYTALFAEWKNQHVLSGPRLVSCSDDRTVRIWRRQPKEQQSQSVFGGTGIPSIIRPIGTDEAWEEEKVLPQMHTLPIYAVAWSKRTGLLASVGADGRIVVYEEIFITAPRQNLDAGSPVDMSPLPYTEWVVIAVLDGAHGIYEINHVTWAKRTDRDRKEKEEEVLITTADDGSVKVWAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN14</accession>
    <name>A0A5N6TN14_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chs5p-Arf1p-binding proteins-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_32633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742204">
        <property type="protein sequence ID" value="KAE8147511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN14"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="678" mass="76660" checksum="F92DCE3A7C8235C9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN25</accession>
    <name>A0A5N6TN25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein sym1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_142419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742191">
        <property type="protein sequence ID" value="KAE8147772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN25"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8147772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="19255" checksum="FB22396A23A596ED" modified="2020-04-22" version="1">MFRWYQTKLARQPILTASVTSAVLFGSGDTLAQQVVDRRGFEKHDFARTGRMALYGGAIFGPAATTWFGFLQRNVVLKSTKATIVARVAADQCLFTPTHLTCFLTSMAIMEGSDPIEKWRNSFLPSYKANLTIWPLVQGVNFAIVPLEYRVLVVNLVSLGWNCLLSMINSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN79</accession>
    <name>A0A5N6TN79_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIM-domain binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="entry name" value="LIM-bd/SEUSS"/>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="158"/>
        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="761" mass="82056" checksum="F5BFDF7A523E8A93" modified="2020-04-22" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        </location>
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            <end position="263"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8147816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="395" mass="44553" checksum="0B0C175148957DE1" modified="2020-04-22" version="1">MFFNNDFEDFHLDIVGFLAILGEGSVSVNYQVSTLSFFTFLPRLMPAPQAFMPPARPLRLDDVPGIVVGARSGNCRHNVYRIPHIILPGEQSMKISSDYTVRRFKIKDKRDNAIDKEADREANNKADTTLISARTFGPLSMLAMLGCAMSIALLGLSIHFNDGWALIATILLSFLSSLLGVACKWTLKLVKRQATGKFIPPADVVVCYPNGSFLIVECDEEIARFLFFAPERCNYLITGTWYRFLALFGTMMLMFGVIALGNAGARMQIGFGASYLLLNAAYWLVAALPESLHWDYSSLEITEPEPEPKHQKPADRKFRDALWKAIKITKTTRWVRTGRIAPDTEAWTEWLKKADEVVNRKDGLDPETWDYSSYLNECLGEYKEGNLSEEPKSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742186">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNK8"/>
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    </dbReference>
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    </dbReference>
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            <end position="226"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNP1</accession>
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        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">BDV25DRAFT_159238</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8062037at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8147968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="236" mass="26229" checksum="AD450579460A3C4F" modified="2020-04-22" version="1">MPPLGYLAPVCAALLVLSVWLAIGLRYRHFRQNRRNNGALDLERMPFRHRPSVISKGEVEKQFPLVKYCDWEANHEATKKEIGSLHSMSDAGRADSVREEKAHEALEHATKPDTGGPPPPSPSDRAQVDSGYFDTNVTCETLAPQIDDLSCLCAICMEGFEGDNYIRPLTCGHIFHPPCVDPWLTKRRASCPLCNKAFSGHSAERREPVVASPRSFVVLPAPRAAMIRGDIFPRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNQ8</accession>
    <name>A0A5N6TNQ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742180">
        <property type="protein sequence ID" value="KAE8148002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNQ8"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF4">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38680" checksum="D39BA1FE1796578A" modified="2020-04-22" version="1">MQLNLDAVPMGQPGILHQYAEKLVAFEYTRGNQSKPNSLLFIGGLQDGLCTVEYVADLVAALQNSDWSVFSLVLSSSYNGWGVGRLGKDIDEVAQCVQYVRDYKRQLFGSGKVVIMGHSTGSQDVMHYISCPNPRPRHPVLDKNVEPLMRSPVDGAIIQAPVSDREGILWVLKAGTERDSPETMREIYRKAVADAKQSTYEDGDRVETVVPLSVTARIGYPSSTAVSSRRFLSLTSPDSPRTPDEDDLFSSDLSDDQLQQTFGAIGTRELLSSKLMVLYSGRDQSVPPWVDKEVLLKRWSVAAGQDFWHQRSMVIPNASHALSDCDQAEPRRILVERVTGYLSEVGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNU8</accession>
    <name>A0A5N6TNU8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_27184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742190">
        <property type="protein sequence ID" value="KAE8147789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNU8"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="560" mass="61497" checksum="0F28C21B02B01FAD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNY2</accession>
    <name>A0A5N6TNY2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_159076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742177">
        <property type="protein sequence ID" value="KAE8148068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNY2"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="498" mass="53949" checksum="1E185486D4FA4EAF" modified="2020-04-22" version="1">MTTVVAVGTPLAEALSNVIQPKLVEMGWSSDGGDDSALTEYVILMLVNGKTQEQIAGELSNDLLGLGEGDTQALDFSRWLFEQVETLNQQINGGGILPSIEGPSAQAIPSFNDQETAELQDPTSAGGAMDADMSMGDGGVNDGIPTGPKAMRNNRQGGRGRMLNQINRQLDRGDSALHRIRGQSGGGRINSHGRDHTKGRFHQNGGRMSGGHQMGGMGMGPNPMLGGPGNMMNMSPNDQMHLMSLLEEQARMMAQFMPGFVSPAINPAFQQNGPQQGRSLFDRVERQQGRRQHGRRDDRNTDVDMDMKPDQAGGEQDESNSDSVCRFNLRCTRRDCPFAHQSPAAPEGTPIDVSDACPYGAACKNRKCTARHPSPAVRSAHQAEELCRFFPNCANPHCHFKHPSMPLCRNGADCTAEGCKFTHLQTACKFNPCLNPSCSYKHVEGQRGGFTDKVWTSDSARPHVSERKFVSEETGAEELIKPGEAPDSSSQNNQEIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPH4</accession>
    <name>A0A5N6TPH4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_142016</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ML742170">
        <property type="protein sequence ID" value="KAE8148214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPH4"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000023">
        <property type="entry name" value="Threonyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="86"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8148214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="526" mass="59276" checksum="F6C6B4ECA0AEB235" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPU3</accession>
    <name>A0A5N6TPU3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_141848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPU3"/>
    <dbReference type="OrthoDB" id="3509531at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34714">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34714:SF2">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="803" mass="87825" checksum="1F44909748935DBD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQD6</accession>
    <name>A0A5N6TQD6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_158462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742164">
        <property type="protein sequence ID" value="KAE8148349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQD6"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="340" mass="37178" checksum="DB9DF70432CC1530" modified="2020-04-22" version="1">MPSLILITGATGLIGFRALLELLRNNYNVRFTARSEAKAQKVLTNSVIQDLAPGERLTPVIVPDMTVDGALDAALKDVEYILHIGNPVPVPGFDPITQVWEPTIKGTANLLSTALKFPTIKRIVITSSIVGNMPLLPDPTKTVTAASRVPSPSPYPTSFPDLFQSYVLTKITEANETDAFVAKHNPHFSVAHIMPGYVFGRNELCLTAEEIRDENSSNRYLMGSITGKDLPFPLHGGYVHIDDLAKVHVQVMCLEPTPQMPSNFGACTDIDYSNLFDIVEKNFPQQVADGTFAPGKLPTLPMSYDSSETEAILGFKFRPFEDAVVDVAKQYLEKLGKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQY4</accession>
    <name>A0A5N6TQY4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_157743</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="ML742149">
        <property type="protein sequence ID" value="KAE8148710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQY4"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="315"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8148710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="578" mass="64001" checksum="A995E945E77AF91D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS74</accession>
    <name>A0A5N6TS74_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative plasma membrane ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_168117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742141">
        <property type="protein sequence ID" value="KAE8148921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS74"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF6">
        <property type="entry name" value="MEMBRANE AMMONIUM TRANSPORTER (ATO3), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="273" mass="29609" checksum="C68A74B6CD66A30B" modified="2020-04-22" version="1">MSDITEKHEDAPTLRQIQTAESVLLPISKDTFEKLYLTPKHPAVAGDIRKKVGNPTPISLLGFLVAATPNAFITMGWRGAGEKGAAILPAFIFFGGFVQILGGIGEWIIGNTFTCAIFFTYGTFWIVQGTSLMPFFATGLLYSETGNAMEGMTSPGYNATVGFYFVALTILTFVYLICSIRTNICLCGALFLLVITLGLFSGTYFQLALGEAALAHRLQYAAGAFNLALCIPIWHIFIAQILDAVDFPFAVPVGDLSTVIPGRSQRVRRDNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS81</accession>
    <name>A0A5N6TS81_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_157134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742138">
        <property type="protein sequence ID" value="KAE8149019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS81"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="251" mass="28667" checksum="B76965419D5E1A90" modified="2020-04-22" version="1">MPSATGTKRVRGVSIFRPFVFGSEAKPFDPNDKPADAPADHTHKWRVYVKGINGEDISYWLKKVQFKLHETYAQNVRSIEQPPFEVNETGWGEFEIQIKLYFVPESMEKPQTLWHSLKLHPYGPDAEAIKERRELVVSQNYEEIMFNEPVEQFHELLTGGPAVAQPQKGKGGKNAKQTVQQGKRTAEIPEKDSPGNPYSKTTENKELDRLAEAAKTVNELIKEEKERLIEREKVLAELRESEGVPANTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TST8</accession>
    <name>A0A5N6TST8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TST8"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="130" mass="14680" checksum="B984566AC367897A" modified="2020-04-22" version="1">MVKTSVLNDALNAINNAEKAGKRQVLIRPSSKVIVKFLSVMQKHGYIGEFEEVDDHRSGKIVIQLNGRLNKCGVINPRYPVQLRDLETWATQLLPSRQFGYVVLTTSAGIMDHEEARRKHVAGKLLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSU5</accession>
    <name>A0A5N6TSU5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742123">
        <property type="protein sequence ID" value="KAE8149433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSU5"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="595" mass="65278" checksum="01375740DD3A43B9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSX8</accession>
    <name>A0A5N6TSX8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_156719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ML742130">
        <property type="protein sequence ID" value="KAE8149229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSX8"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="420" mass="47453" checksum="918BFFD31146F66D" modified="2020-04-22" version="1">MSSKSRWADEDPETEAIVARQKREKEEKRRAKAEKQRQLVQQQQQQQTSQHDESANGETDARPVKRRRLSNDPQKTPETVEPERPKSPEKSTLLQFPAQTWGPCGHITNFERLNHIEEGSYGWVSRAKDITTGEVVALKKLKMENSQDGFPVTGLREIHTLFEARHPHIVYLREIVRGTRMDEVFLVMDFLEHDLKTLLDDMREPFLPSEIKTLMSQILSGLDFLHSQWIMHRDLKTSNLLMSNRGEIKIADFGMARYYGDPPPKLTQLVVTLWYRSPELLLGADKYGTEIDMWSIGCIFGELLTKEPLLQGKNEVDQVSMVTPASLYLLGPRPTDTIADICLDRTSNTADMAGLPLSPQRQIPPCPTNFIRSVEQSTLTAAGEIPLLNQCRSAATVCALGAKPGLTAYGERMSLASVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTN5</accession>
    <name>A0A5N6TTN5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_172739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742117">
        <property type="protein sequence ID" value="KAE8149644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTN5"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="463" mass="50473" checksum="2AA9F980E4B66AA5" modified="2020-04-22" version="1">MTMFASHVARLVHERFEALPGRSKPCVRGDGTREWVPMVGVVVVRGESANEEIACVAVTSGAKCLPASQVSKCKGLVLHDWHAEVLALRAFNYWLLCQCRYAAEEPGAYVRRRTSPDADGPPFELNPDVRVYMYCTCAPCGDASMELCMAAQEDATPWDLIPSSSVSTGAGAEDGAEELLDGRGYFSRLGIVRRKPARADAEATRSKSCSDKLALRQVSSLLSYETSLLVAVTENAYLEGIVLPETEITAVGYARCFGEEGRMAALKGREWSGYRFRAFTVLSVPREEVDVLWAFGKEESTASLSLRSDKSSAGKSKPAVVSAVWVAAPERDVSDGVKALPKLCGVKTGLYETIINGVKQGNRASEPMARGASALSRARLWGLAREIVCGEKQGEGSVLRGIVEARSYREFKKEATVLTGSLEQRKNAVRDAKAVLKGWTPNIRDEEWGLEVLVDPKKRKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTR8</accession>
    <name>A0A5N6TTR8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_140470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742113">
        <property type="protein sequence ID" value="KAE8149758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTR8"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26944" checksum="05F3B9CDF81C5F0E" modified="2020-04-22" version="1">MATPFSFLSGSRPGVDTCNFQIHPSIRFKGHAIANVTGTRLEVETRRSSEKSPRRKRRLNTADKLPKDLIGKYDLVYVRLLPPLAEKVKARVVGNLYRLLRPGGYIQWDELDGENMRVRRDDPGAQTPAMDKICEGFAGSRGSDEAVEVPRLLAGRGFVSVEMESWGEKLDLESMARERWIVEAKGWVDDVDDGRIWKDAYQESLQGAALWVPRIVVVGKRPMRRCWGWLLGLVCFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUJ8</accession>
    <name>A0A5N6TUJ8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isoprenoid synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_155650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742112">
        <property type="protein sequence ID" value="KAE8149789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUJ8"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18602" checksum="B9A1D92E9D3F6EB5" modified="2020-04-22" version="1">MLGNIVESAVSERLNLPGSFSRRASQFIRDKTGAGEVYAHFMFPEHLVKETRYLPTYAPVIACIRDIVDDVNDILSFFKESVVGSETNTHIMNRARASCCSPDDVLEQVCRDAAETIHVASDAVAGEEVVQQLLREFVNGYIMWHLCEDRYWIKEVGIVMTEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUX4</accession>
    <name>A0A5N6TUX4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">rRNA-processing arch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_155032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742103">
        <property type="protein sequence ID" value="KAE8150090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUX4"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
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        <property type="entry name" value="Ski2/MTR4_C"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="167"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="403"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122357" checksum="DB8F895EA56DFA0A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV45</accession>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_115003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV45"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="698" mass="75375" checksum="941D48CB913838ED" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV85</accession>
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        <recommendedName>
            <fullName evidence="18">BCS1 N terminal-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_113763</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV85"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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            <end position="270"/>
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            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
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        <name type="scientific">Aspergillus avenaceus</name>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
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                <person name="Andersen M.R."/>
            </authorList>
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            <strain evidence="1 2">IBT 18842</strain>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000325780"/>
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    </evidence>
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</entry>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">IBT 18842</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF39">
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    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8150473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="552" mass="61969" checksum="E672CF1CE5822681" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWB0</accession>
    <name>A0A5N6TWB0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8150673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWB0"/>
    <dbReference type="OrthoDB" id="4505782at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PHISTB DOMAIN-CONTAINING RESA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36193:SF23">
        <property type="entry name" value="PHISTB DOMAIN-CONTAINING RESA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024830887" evidence="2">
        <location>
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            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="315"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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            <begin position="847"/>
            <end position="862"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="977" mass="105751" checksum="DBE97EBDA023397B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWF6</accession>
    <name>A0A5N6TWF6_ASPAV</name>
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        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_107033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWF6"/>
    <dbReference type="OrthoDB" id="4435769at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="186"/>
            <end position="282"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="467" mass="50539" checksum="DC154EBA2C5ED13E" modified="2020-04-22" version="1">MVVDSLEQHLSKAGCTNAVKQSSPSAADNSTCRPRKKGGRSQSPRAMERRRLQNRIAQRNHRRRMKERTAAGNMDDIQEPQTTSISQPASSDNSNKTNTHNTSSQPFSSSSSSSSHTMDTTFLTDDLHKSSMSLGFDPMMPQVTEGEALSSIPGLDLFPMSSSCTCNVVTGPCAGHLEEIRSQVLRSPMATPNSQSMPRLRATPGSSYQDASNQPAQYMESSPISVDLTSSHDSRSHQLAPSTASRSSSSSARSIPSPGISNRESSKRSRAARSPSSGSTVSNAVVQNTARFKTILDVVRSAGFADFDRMAAAYYTAQFEKDSLPDITQRASRGWRLNKLLQELHESSRNWSPWESRGLREGVIESATMECIDEIDRIANGHFQGCNSDSSSESMDIKGNVSDSSTGVGSLACLPTLPDMVDSAVQDTAPYLWGLVTELAGPESIHCNRVSNAVLSLLADARRSQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX15</accession>
    <name>A0A5N6TX15_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_129386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
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        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="318" mass="35167" checksum="A4EA309826E0CE0E" modified="2020-04-22" version="1">MSTSSRPQLIYGGAGIGQEWTTRESISELLQTLESLGISRIDTAPRYPSTKPGESERLLGENGAAERGFTIDTKILVSSPGASGTLEPQAVDESLNTSYDRLRFPVGEKINVLYCHMPDPTTPLEEQAAGLDAQYRRGRFERLGVSNFSPDLLAQLLDICERNGYVKPTVVQNMYNLVDRESEQIIPLLRKHGIAFNAYSPLAMGFLNGKLTSGDIQGTRYAEGNAMGAHARTRYDKPKMHDAIMFLTRTLEPFNISKPEAALRWICYHSKLGSEDGVLLGASKIFQLKQNVESIERGPLPDEVVSAIEDLWKTLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX25</accession>
    <name>A0A5N6TX25_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX25"/>
    <dbReference type="OrthoDB" id="4505696at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="84" mass="9412" checksum="CA2A4F410683F592" modified="2020-04-22" version="1">MAQIPTAGVIVIVIVACLAAVSLGAALTKQLWPSDSGHHRYQYSRDQELYMRSVRLKNLGHFERESRTKDLESGVYTENGSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXC5</accession>
    <name>A0A5N6TXC5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solid-state culture-specific ATP-grasp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742087">
        <property type="protein sequence ID" value="KAE8150731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXC5"/>
    <dbReference type="OrthoDB" id="5946236at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="170"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="469" mass="51903" checksum="8FDDF67C168BD4E0" modified="2020-04-22" version="1">MAPQFPPVELDRTLHDLYAEDNGDPNNVAHVIALAPPFQCAAPLPPNKKYIYQTPMAPRLDGDVYARICLGNGAQNHGFMSGPIPLYLFDIDPPQYDVANLQIESPPAARTDAHRVYNCLVPWQRPKLRFISDPQTFKPSAPVSPYPPLDFLDKHACIVSQEAHYGLLSKRNLALSGLPAAPGTVIEGSLAPEEVQDEEKVARETQRMLDVVRARPTPFVLKFPQSLSGQGVFVMSDEESKASRMPFLEGEVARMIRTLTPENAVLSPVSLVIQAFIPGNYTRNLSLFITHAGRPIFISCAEQFLDDEGIYRGSILDYHAQEELEGQYKDTIEKVAAHVHKQGFYGPMGADVMTDPSTGTQYIVDLNVRITGDYMMGPLRGHFLERRGLAVSYLITPLVVLGDRDAFEERFESEMMEGRMIVIGWVRGKGGRSGKHVYSVASVVIGGRDREHALELVGRVNALALAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXQ9</accession>
    <name>A0A5N6TXQ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_153592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742083">
        <property type="protein sequence ID" value="KAE8150879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXQ9"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="56"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8150879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="215" mass="23877" checksum="01DD3390D58B555B" modified="2020-04-22" version="1">MSDHGEVEVENPAGAFQVLPKEAIAEMGSVKLFNKWSYEDVEIRDISLTDYVQIRNPVYLPHSAGRYAAKRFRKAQCPIIERLTNSLMMNGRNNGKKLMAVRIVAHAFEIIHVMTDQNPLQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQSIALLTIGAREASFRNIKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXY3</accession>
    <name>A0A5N6TXY3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_153037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742076">
        <property type="protein sequence ID" value="KAE8151180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXY3"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="170" mass="19672" checksum="91557D4371816A40" modified="2020-04-22" version="1">MAQPGSLIHTFPRFKIRGVYLYFHIVPADDCLFNMYEVDHSPSGLPYPKLESFAQSLLDTQRRVELEDLIDGMDLTEEWGEEHLNLDKTTDVAYAKQKNEKVLASVPPGENPMTYSGVPARPTPLREIWQYHVRGKQRRISLELPVEYFATRFHAYGRGDPRLDTTRTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYA4</accession>
    <name>A0A5N6TYA4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_152682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYA4"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="317" mass="34586" checksum="97F12B2D4F4921B3" modified="2020-04-22" version="1">MASLPASELRTFQEYLKGSKRILALLGAGISASSGLPTFRGAGGLWRSYDATDLATPEAFESRPDLVWQFYSYRRHMALKAQPNRAHYALAELARRNPDFITLSQNVDGLSQRADHPSSQLHLLHGSLFTVKCTSFYCNYSRENDFTDPITPALQIPRKIPGSSLASGGKTANGTSQPRYDTLGVLEGEELDISDARIPLHLVPRSSLPQCPECKDGLLRPGVVWFGESLPLSNLELVDTWMEDSPIDLILVIGTSSRVWPAAGYIDKARAKGARVAVVNMERSDVGSAGLQAGDWFFQGDAGVIVPEILKEVIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYF8</accession>
    <name>A0A5N6TYF8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AflR-like C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_139171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYF8"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53266" checksum="4280163C91C9C750" modified="2020-04-22" version="1">MSRRLGRPAKKKDVPRDDHLEFGHAEHARQQVNRRVRSPKKRKVKEEQEYQRTNKELNNEEDDDLLFDQITFDDTMVDDIPTESACLPTTAFVDTEKNSPFDAPDNIDLSDSWLQEFMSSQPSDLTQDRNLLDALGLGNNNDSEFSSISTGSKDHHCSYKAIEMSSDVQDHVPLGAYYTTGNNFVAYSEPVMESMQGATEAISPYADYAKKDLLSWPEPLSSVVENGSARLLVANEQANFIPPTKGPRQDHDYAPSAENPRLVAGFTPPQYQCQCHERTARDLMCVNISASHTWPTVTIESILSCQQILHQLADSILRCAICCKSRVNLLMIVVVSIDSLITTLETITSVDSSGTDGFSNEQHGQRFRDWGHDIPNDASNRRYKSASFYFKAQVEACPLSVGGFPVPPEEKLSFIKQVLHDRLCGLSNIISRIQFCTREMLAVPASQGRLQMIVETDRRLQLVMTKMRTPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYI2</accession>
    <name>A0A5N6TYI2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_171553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYI2"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="512" mass="58102" checksum="C542F19787277922" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYL5</accession>
    <name>A0A5N6TYL5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742070">
        <property type="protein sequence ID" value="KAE8151472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2582433at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF604">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="884"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2741"/>
            <end position="2782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2745"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2773"/>
            <end position="2782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="2782" mass="313457" checksum="67A25D5E9ADB774E" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZ76</accession>
    <name>A0A5N6TZ76_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_152689</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZ76"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="14">
        <location>
            <begin position="72"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8151371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="498" mass="55337" checksum="50BEB041E8931357" modified="2020-04-22" version="1">MSSCKLFARQLPRYLRPTSCIAHISINRPALQTRPVLRRGYASISAAELKFGQPLHETHPHILNPGELTPGITALEYAQRRSRLANKLPKHAVAVLSAAEVTYRASGIFHEYRQDSNFFYLTGFNEPNALAIIANDGSGDNHLFHLYVREKDPKAELWDGARSGTRAAMDVFNADESGDIERIGDILPRILGDATEIYTDIPAFNPGRSSLHRYLYGPTGASEKLKKIVDHHKVKPLRNILNEMRAFKSEDEVVQLRRVGQASGRAFTESMRQTFTKEKALTSFLEYNFKVKGCDGSAFVPVVAGGSNALSIHYTRNDDVLRDGDMVLVDGGGEMGTYISDITRTWPVNGKFSDPQRDLYNAVLNVHRSCVALCRENANLSLDRLHTIAENGLRDQLQQLGFDVSGNAMGILFPHHLGHYVGLDVHDCPGYSRGYSLKAGQCITIEPGIYVPDSERWPEKFRGIGIRIEDSVCVGDDSPIVLTTEAVKEVDDIEALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZI2</accession>
    <name>A0A5N6TZI2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_138607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742066">
        <property type="protein sequence ID" value="KAE8151684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZI2"/>
    <dbReference type="OrthoDB" id="4501024at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="116" mass="12971" checksum="790FD7F870E2C529" modified="2020-04-22" version="1">MPGRSSLRDISACGNLLNSMNTWRLATSVAIHVMSGDYQEATFTYIINTIEEQYSMYPSSDDESIKQQLRGFLMRCAELKVTLIRQKQLFSFHYSPPGTESMSQSMNFGGADGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZW0</accession>
    <name>A0A5N6TZW0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_138665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742067">
        <property type="protein sequence ID" value="KAE8151639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZW0"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8151639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="533" mass="57269" checksum="6BE58404CC73C307" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U175</accession>
    <name>A0A5N6U175_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_71897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742055">
        <property type="protein sequence ID" value="KAE8152308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U175"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="702" mass="78607" checksum="716279DC83EF3ABE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U179</accession>
    <name>A0A5N6U179_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_76561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U179"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8152119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="86511" checksum="309694AF0306CC0B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1D9</accession>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">BDV25DRAFT_128204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742057">
        <property type="protein sequence ID" value="KAE8152199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="629" mass="70441" checksum="A6177CDCBA62CE48" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1X4</accession>
    <name>A0A5N6U1X4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_150691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
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        <property type="protein sequence ID" value="KAE8152596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Calcium homeostasis protein Regucalcin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="309" mass="34499" checksum="8E0EF196305B0394" modified="2020-04-22" version="1">MSEFQKWTVTEPYVDISGTLLEGPFYDKAKNEFRFVDIWEQKFYVLDLAKGPDSLKTLDTSASIGVTANIDNSGEAYSNKVIVAAKHGYALLERDTGELSYISKAWDNPDKAHRMRFNDGAVDSHGRFWAGSMNDPKVQSPVSEAVLFRLDPDLKLHRMVEGLTIPNGIGWNQSNDTMYLTDSPTGKIYAFDFNAQTGEISNRRIHFDLGEPKEPDGFAIDVEGCIWSAIYGGGKVIRISPEGKVIGEVLLPTRNITCPSFVGTELFITTAKDDTNDEQFPNSIRYGGRVYKVDVGIKGKPKNEFQFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2B4</accession>
    <name>A0A5N6U2B4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_137531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2B4"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024922992" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="73"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8152726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="59277" checksum="EF4CCCC558CE8E02" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2B8</accession>
    <name>A0A5N6U2B8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_137581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742048">
        <property type="protein sequence ID" value="KAE8152774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2B8"/>
    <dbReference type="OrthoDB" id="4332097at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="116" mass="13244" checksum="52365E8EF6111A27" modified="2020-04-22" version="1">MIIFLGKLNYSPYASDEIFSVIFRDNIQPGDRVSVILQWSKDGSGRIKANSSNNGTISKVSHNGDGEKEIEFLYNEKDTTYYWYKGRVSGHKLILSMWNKSGEEVAKDIQLNPVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Q8</accession>
    <name>A0A5N6U2Q8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SacI homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_50055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Q8"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="666" mass="75158" checksum="6F5052A42B308B29" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2Z7</accession>
    <name>A0A5N6U2Z7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_50403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2Z7"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="515"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="673"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8152900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="719" mass="80569" checksum="6A2489C606EC182B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U324</accession>
    <name>A0A5N6U324_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_127507</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U324"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="462"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8153025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="816" mass="92608" checksum="B55F54E65AB8F13F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U338</accession>
    <name>A0A5N6U338_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the recoverin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
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            <end position="131"/>
        </location>
    </feature>
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            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8152839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="190" mass="22030" checksum="B52A1D46ACEDBB50" modified="2020-04-22" version="1">MAFSQSKLSPSQLDELQKATHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPSSFANYVFRVFDSDNSGMIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKITYEEMLAIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMEEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3D3</accession>
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    </protein>
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        <name evidence="8" type="ORF">BDV25DRAFT_137154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAE8153084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8153084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="550" mass="62086" checksum="C4DFDE607679EDBD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3P4</accession>
    <name>A0A5N6U3P4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_137098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
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                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
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                <person name="Isbrandt T."/>
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                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
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                <person name="Mondo S."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024850653" evidence="1">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="124" mass="14048" checksum="F6A8E332222391F4" modified="2020-04-22" version="1">MRCLSTAAAAIALFTTGILSTEVHIAYQTEDGHYRQVLDPRHLTQLDHPGNMDKIYSTANCLLRAKPNGRVRPIKTGVTAFNPPRYVAFIFCNEPSTVSHKSESHRVPFEESLQEDIWWDQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3Z7</accession>
    <name>A0A5N6U3Z7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin interaction motif protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_149798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3Z7"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="83513" checksum="2924D53C0A5FCF0F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U404</accession>
    <name>A0A5N6U404_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="14">High osmolarity signaling protein sho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_149802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U404"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8153318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="311" mass="33622" checksum="CD1370C93F809BBA" modified="2020-04-22" version="1">MVAYSAHSPSLHKPSPYRESPRKMARFRASNILGDPFALATISISILAWLIAFISSIVSAINVHSYPTYSWWGIAYEFCLIVGMTLVFGTDTGLVYGVAIVGYLSAGLVIETLGVNSLVYRSDSASQAAGAGFILMSMVIAVWIFYFGSTPQASHRGFIDSFALQKEHPAAYANGRPMSTAFGNRPETTSSQAPQMYTSAQLNGFETSSPVSGYPGGAPGSENRSSSQPRFGNPSNGNLPSHNGDEVPQPTEYPYRAKAIYSYDANPEDANEISFSKHEILEVSDVSGRWWQARKSNGDTGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U486</accession>
    <name>A0A5N6U486_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_137124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U486"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF6">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="177"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="346" mass="37420" checksum="DB1276ACE90BA454" modified="2020-04-22" version="1">MQAVIFKGPLEVALEQRPIPQIEQPTDVIVKVRYTALCGSELHVFRGHQPSGTGFIMGHEFTGEIADTGAAVQKFTKGDRVVSPFTVSCGECFYCAKRCSSRCARCQLYGSAVLDGGQADYVRVPLADATLVAAPAAVDEKKLVLMADILPTGFFAARNAFRGDAADSTVLLFGCGPVGICALVSALEHRPKHLIAIDSVPARLDLAKSLGAEAWNFEKDADGLRQRVRDLTDGRGADVAIEVVGHSSALRMAFDMLRPWGRISSVGVHNGEIPWTGNEAYGKNLQIQMGRCPVRSIFEEALAFLVEKQDLLDFMVGDIRPLSAAVQAYDDFNAMRSQKIIFEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4N2</accession>
    <name>A0A5N6U4N2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_168757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4N2"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="904"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="12">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8153548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="936" mass="104838" checksum="809A8DEBC34C4441" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4P3</accession>
    <name>A0A5N6U4P3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectate lyase</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_149385</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4P3"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000036">
        <property type="entry name" value="Pectate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 15 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025060944" description="pectate lyase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="17">
        <location>
            <begin position="50"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8153558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="321" mass="34261" checksum="1946CC1277EAD421" modified="2020-04-22" version="1">MANFKLFLALAACLSGQALAAPTKTVGKRAAITDAAHGYASLNGGTTGGAGGTTTTVSSYAQFTDAVSSDDKKVVVVDGTISEQAKQVKIGSNTSIIGKDANAILEGFGVLVKKKENVIIRNLGVKKVLADYGDAIGVQYSNNVWIDHCDVSSDRDHDKDYYDGLIDLTHAADYVTVSNTFVHDHWKAMLIGHSNSNGDEDTGHLRVTLNNNFLYNLNSRGPSFRFGTGHIYNNYYVDVSDGINSRLGAQLLVEGNVFVDGKKALYSTDDGYAVARDNDFGDAKHTAEEGTLTSVPYEYNLLSASEVQGAVYGTAGQTLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U511</accession>
    <name>A0A5N6U511_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U511"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024909614" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24626" checksum="0E2F7E30C8C58932" modified="2020-04-22" version="1">MHRFLIILTLCLSLIGKTFAIEPVSPTPTTSYRYINEACRRVSVIPTQDVSNAPPEPSRTGPNAREDPPRREINRRDLHSNSSKIIAPRLQPPTQNTAAGPPVQLQARCLPARDPRGYVRSSIPLNDCLAWDAANERLIPATPSRRNGLVDGRCWGCRSNGGQGTGLEFAIICFCDNVQNTPLVQVGPYAQRRAARITFNDRDTIMADDNGRIVCPRAEGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U565</accession>
    <name>A0A5N6U565_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_148800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U565"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="4">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="198" mass="22638" checksum="08C5D86351A3C23E" modified="2020-04-22" version="1" fragment="single">MAEVAITYPSNVLVHECRKRPSTACNVEVGKRMSSYAIVNQADGSSVQLAKKLSSNGRWKLLVFSGDLYSPGVLDRLLLFAKEFKDWVQPFSKPWKRQCHLFETVLIHSNARACANVLNLPEIFEHFEKELGWDYEKVFADDPSYDGNSGEVYDRYGIDKEKGCLIVCRPDQHVGWIGGFEDVKGLEEYFSKFLMRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U590</accession>
    <name>A0A5N6U590_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_18267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U590"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845547" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="88" mass="9548" checksum="94768FD7AB62AD55" modified="2020-04-22" version="1">MKFFAILPMFVLAHFALGEGEDVLKNLEPENCREGECNKPPGCQDCTTYVEVIQTVRPAVTVSMTNTHIECPTTIAQSTIGCKPTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5B1</accession>
    <name>A0A5N6U5B1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_148772</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5B1"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="211"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8153768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="542" mass="60170" checksum="3BD7557F69040C5C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5C3</accession>
    <name>A0A5N6U5C3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BDV25DRAFT_14557</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="ML742035">
        <property type="protein sequence ID" value="KAE8153774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5C3"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="154"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="481"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAE8153774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="569" mass="64507" checksum="EB632E994B950F86" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U606</accession>
    <name>A0A5N6U606_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8154028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10017208at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="59"/>
        </location>
    </feature>
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            <begin position="20"/>
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        </location>
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            <begin position="327"/>
            <end position="359"/>
        </location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="359" mass="39778" checksum="6990F46516F8D8C8" modified="2020-04-22" version="1">MYVVPVASTLLALSIVIVAVRLYARLYFIRTPGWDDLVIVVALLSAIACFAFIVIEVRYGLGNSIQTISPKDLRAQMKALWVSIPFYNLSLTLTKASMVLLYLRLFPLRNYQIVLYLILTFVILSGLWMVFGSIFECIPVQGFWDPSIPHRCIPRTAMWSLNAALQISTDLTIVIVPMPLLTQLQLPRRQKMALILVFALGLFVCAVSAVRLAAVVKMIQSPDKTKWNESAALWSIVEANVAIICACLPPLRPLIVHIFPRLFASQVRSQPEKPPLNLFDTANPFNFQNTSYAASVTGNCSTNNNGRDPHPDTEGIQVVSEVHWDSGSVDGIEDDHSQKGLEPSGRGTVPGRERMASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U650</accession>
    <name>A0A5N6U650_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_148647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U650"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="600" mass="66497" checksum="C0E34F4EF1B6B05C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U719</accession>
    <name>A0A5N6U719_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_172394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U719"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8154374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50881" checksum="3D2C0327D0072078" modified="2020-04-22" version="1">MSSVTVPPRVPQDDRISALEERLRELEDVISSSFRSLRGAIQHVSTHVGLTDGNGGIARGSTDLSAFSPSVVNDPSPEPFGLDREEQDLVGKGIVSLHDCRALFDFYGANCSEVIAYYDNTLGSFEEVRRSPLLLAAMCTIGARASAPRLYDRCLKETYFLIQQTLLGPVPSLESLKGILLMAVWHKNNRLWGLALSISYQMRLPEAALDLADRTKKLDEHSIMGNIQEQPMMPNTCQLLQTYNQELESWYRRTNQEIDPIYQTFSKPQDRNRLEIPYDYGRIYINGSVLQGLKPDTARKDPLRAQFIRAAVDAGKALVECALHSISYQTSLNYSIDYSGSSLGLAINFLFRATCIAYDCIDVDEVMRILGRARDMFESAKLAGKVDEVNHILDLIADIKRNMDTTVAPNLTSMQASNDRVDEYSDFFLNARLPLSEFSLDESAIEDILMYTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7G1</accession>
    <name>A0A5N6U7G1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">BDV25DRAFT_147753</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154490.1"/>
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</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7M3</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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</entry>
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        <submittedName>
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        </submittedName>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
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                <person name="Riley R."/>
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                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
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                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54105" checksum="D9668B65B3078106" modified="2020-04-22" version="1">MSLHTSYHADSDADDEYERSVITSPHLATDSEVSPSESDFPSSEHTPTSFANLNEHPKSPKTIITEWTVEECARFIAALGVQFQKYCATFLENEIVGEALIALKHDELKEMGISSVGHRLTILKSVYETKVKQDIPLDADHYIPLSADQSMNENASQEDVARLIQSIRLRDERIVTVESELRRMADDYRRLREELLPVFKMAKDRSQPLPPPTSMGVPNTDNYHDSQQTLVSPSGITMLERAGSSISRTFSKRVHTGGTTPKNNSPTHIPPSIHEGRVYHDTSGLDPSSAHYPNGKSQLSPGIPSPTSPGAHYAPAQTLASRSYNQTTPNGGRSPYDHHDDLTSQPRERLNPTPTQATRPDIPTRSDSRAGNDPPSVEIFKSFRVSMDDPCHKVLPAALKKYNINADWKQYALYIVYGDQERCLGLEERPLILFKQLEKEGRKPMFMLRKQLQQPVESSYPPVSAVPTSAGFEGRQAQINLPGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U9F2</accession>
    <name>A0A5N6U9F2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc/cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_146362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U9F2"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="313"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="392"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8155232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="532" mass="58133" checksum="01118C1CCE91897F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UA29</accession>
    <name>A0A5N6UA29_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_167730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742023">
        <property type="protein sequence ID" value="KAE8155319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UA29"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8155319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="576" mass="65637" checksum="2F7387B81B866A47" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UA56</accession>
    <name>A0A5N6UA56_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDV25DRAFT_146869</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UA56"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="15">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAE8155031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="377" mass="42596" checksum="C57FA22107C170A8" modified="2020-04-22" version="1">MAPTSLEQENHTRDAEFNRVLHGKSSQATGGFSAMRGKDAAAQKAAVDEYFKHWDNKDAAEETEETRAARRAEYATLTRHYYNLATDFYEYGWGTSFHFCRFAHGEPFHQAIARHEHYLAHTMGIKPGMKVLDVGCGVGGPAREICKFTDANVVGFNNNDYQIERATRYAEREGLSDKLSFVKGDFMQMKFPDNSFDAVYAIEATVHAPELEGVYREIFRVLKPGGVFGVYEWLMTDEYDNDNAEHRKIRLGIEQGDGISNMVRVSEGVDAFKNAGFDMLHHEDLADRPDEIPWYYPLAGSFKHMTSPWDFFTIARMTWWGRGLAHRFVGAFESIGLFPKGSQKTADSLALAGDCLVAGGEKKLFTPMYLMVGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCW4</accession>
    <name>A0A5N6TCW4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_146026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742814">
        <property type="protein sequence ID" value="KAE8144127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCW4"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8144127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="82" mass="9420" checksum="6D19BC83E0900B06" modified="2020-04-22" version="1" fragment="single">ETAQLEAQAYELEQRTALAHEAKQALDSWVRYEGQVKQRQQRELADTVIGKIQKELENPKVLQQILNQSVADVERIMSTKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDT5</accession>
    <name>A0A5N6TDT5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane adaptor Erv26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_166697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742504">
        <property type="protein sequence ID" value="KAE8144492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:COPII receptor activity"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erv26"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="235" mass="26418" checksum="6512BB70DEF85DA5" modified="2020-04-22" version="1">MWILPLIGYMGVIVGFSFLTLAIASGLYYLSELVEEHTVLARRILNRLIYTIILIQVLLLVFDRFPFLLSLLSIGSHVIYASNLRRFPIVKLSDPFFILSCVLVGLNHWLWFRHFSRPLPASRAASNWRQPYKLDVEDMPTFTEVASYFGLCVWLVPFALFVSLSAGDNVLPSIGSEYATGDHVPPVGLARSTLSSDGKSKNKGMAKALVDGVRDWVSENGELMGFWRGGRSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE24</accession>
    <name>A0A5N6TE24_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_166398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742472">
        <property type="protein sequence ID" value="KAE8144628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE24"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF84">
        <property type="entry name" value="TESTIS SPECIFIC SERINE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="343"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="675" mass="73563" checksum="4301B5896C44BFEC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE73</accession>
    <name>A0A5N6TE73_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">BDV25DRAFT_166956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742541">
        <property type="protein sequence ID" value="KAE8144391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE73"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8144391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="170" mass="19168" checksum="900A54832A82CF68" modified="2020-04-22" version="1">MTSTLTQVDTDLKEIIQHLFEIQSAVHGYLGPETQQELVRKIKNLTQSLKTLSSHTTPTPTTQESTTTNTNTNNQESTQESTQEKERNPYVQSIQLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKKEAFLSFRDVLAREMRGGMPELGGEVDRVLSFSSSSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEH2</accession>
    <name>A0A5N6TEH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_166104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
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                <person name="Daum C."/>
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                <person name="Isbrandt T."/>
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                <person name="Chovatia M."/>
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                <person name="Henrissat B."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742375">
        <property type="protein sequence ID" value="KAE8145184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFN4"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8145184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="325" mass="35845" checksum="85D4551E47D8B8EC" modified="2020-04-22" version="1">MADNHNRKQFILNAFVMNTPGLLSAGLWKHPSNKTDQYKKLSFWTDLAQLLDRAGFHAMFIADTLGPYDVYKGPGNVVPALASGAQFPVNDPLYLVPAMAAVTKNLIFGVTASVTYEKPYSLARRLSTADHLSDGRLAWNIVTSYLDSAARNHGLKEQIPHDERYTIAHEYMEVLYKLWEGSFRDDAVVNDRERGVYIDSDGVRPINHQGKYFEVPGPHFCEPSPQRTPFLFQAGVSEAGNAFGGKHGEAIFVGGQAPEGVRATVDNIKKVAMDEGRDSNHIKVIVGINVIVAATDEEAQAKREEYVKYVDEEGAGGSTESNRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFQ6</accession>
    <name>A0A5N6TFQ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative heat shock protein Hsp98/Hsp104/ClpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_165167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742372">
        <property type="protein sequence ID" value="KAE8145208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFQ6"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="427"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8145208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="927" mass="102712" checksum="93B4ED5C86274443" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG58</accession>
    <name>A0A5N6TG58_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_72302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="ML742352">
        <property type="protein sequence ID" value="KAE8145375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG58"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8145375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="355" mass="37799" checksum="2948ACE9CCF9FF2A" modified="2020-04-22" version="1">MTDAAKNLSIVLEGVHQVKFEDRPIPELRDSHDVLVNVKFTGICGSDVHYWEHGSIGQFVVKDPMVLGHESSGVISEVGSAVTGLKVGDRVAMEPGIPCRRCEPCKDGKYNLCEKMAFAATPPYDGTLAKYYVLPEDFCYKLPENIDLQEAAVMEPLSVAVHIVKQANVSPGQSVVVFGAGPVGLLCGNVARAFGASKIIAVDIQKGRLEFAKTYTATAVFEPGKAPAMDNARRIIEENNLGSGADVVIDASGAEPSVHTGIHVLRPGGTYVQGGMGRSEMTFPIMAACTKELNIKGSFRYGSGDYKLAVGLVASGKVNVKELITGVVKFENAEQAFREVRAGEGIKTLIAGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG82</accession>
    <name>A0A5N6TG82_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_164775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742350">
        <property type="protein sequence ID" value="KAE8145395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG82"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8145395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="61" mass="6995" checksum="0724F505F73A3B4B" modified="2020-04-22" version="1">MILLDFNDEVSRQIVAITTIGITDQFPQTVIRGIPFIATFFLLLFLFLFFISERVRASSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH56</accession>
    <name>A0A5N6TH56_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_164367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="ML742332">
        <property type="protein sequence ID" value="KAE8145580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH56"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8145580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="42595" checksum="C690963C097693A6" modified="2020-04-22" version="1">MAPHNIRWGIVATGWIASTFVKDLLMDPKIRGASDISHTVVAVASSSSKSRAEEFISETGIPAPCAAYDTYKDLVDDPDVDVVYVATPHSHHYQNVMLAFEAGKHVLCEKAFTVNAAQARILCETAKKKNLFLMEAVWTRYFPLSVQIRELIQSSTIGEVLRVLADNSFGDDVEEKWGTGHRMVNKDLAGGALLDLGIYSLTWVFQTLYHTLPREARRPPSKISAHMSLYHLTGADEATSILLTFPSSTPSNFPRPGESQALAMTHLRVSTNVTNGPVQPTIRIQGTKGEIQVFGPAFRPERYRIVPKDEGETREVDCPFPGDGKGMFWEADEVARCLRDGKLESDGLPWEESIVIMEVMDEVRRQGGLTYPKSIESTIYPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TI60</accession>
    <name>A0A5N6TI60_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_163290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742291">
        <property type="protein sequence ID" value="KAE8146035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TI60"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="68" mass="7693" checksum="EF7CB31BCFB8E685" modified="2020-04-22" version="1">MNTIGGKDHRKWVIFLAIMSLSLAFVYSHKSRPPNPVLTVLVFLDPARNHDGLSSIQRRSYISRADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIF6</accession>
    <name>A0A5N6TIF6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A1 cistron-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_56016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742286">
        <property type="protein sequence ID" value="KAE8146112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIF6"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000003">
        <property type="entry name" value="AAR2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="242"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="462" mass="52096" checksum="BB5889E7A3AB80F4" modified="2020-04-22" version="1">MASITPSPTILVPHLPPKTLVGVDLITFNSTPNFHGIRDLPNGWHFLYTGATQSLSLRSGGWFYVGDISTAEDSDSEAIISTRARGLGAEIVVWKWDTGTETLSPLRAGNDVDQQEAMRHKANLAAVWQSGGLFRYRSRVPLSSLMRGAPNSRARLQDEDDEENEEEGRRDWESLTDRLTPSLLTRVVGNPEIDVDNRPRWMVTSASTAQRDNENIPGIPEPGQGSEKTANVIGEQESEFSFLVIDLKKTWREGAIGRERSEAAQDRSWALGDLVQQISGAGPDGDKARERLGEEQILGELQFTFLMVLTLMNYSCLQQWKRLLHLVLTCQKAIKEREQFINDVLQLLLLQLERCDDIEGGFFDLDGEEGGEFLRKLLMKFRTSLYEVVDEPPALVKYTFEKVATWVKEEYDWELNRGAFVRRGMLQLEDGEEVELEMKHDEDDEMGEYAPVVVDLGEGTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIP8</accession>
    <name>A0A5N6TIP8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742276">
        <property type="protein sequence ID" value="KAE8146244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIP8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="293" mass="32356" checksum="D74E0ED59B2E3081" modified="2020-04-22" version="1">MHHRSGSHSYQTTGSRSSSTHGTSSAFSPNANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKRRLEDLEKRAASASESPERTHEKIEPPKTAHTAKSRSRNPRISKSNSDSSSRTGTERATAYDGYAAQDDRQAMFAHQCTRQLSASPPPVFSYPSYPHLDPYGQSTYGQQPSYHALHHSYNDMTLQGEYGTSIPSILPVTMSTTGPIKRPPHVYADEDIISPFSMSYASMAGIELCSSSQHLSEPNIPMPPLSHVCSDDHSSPSTPAEPSNLGCPLTPESGPCSPHSYPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TIS9</accession>
    <name>A0A5N6TIS9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_163371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742294">
        <property type="protein sequence ID" value="KAE8146009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TIS9"/>
    <dbReference type="OrthoDB" id="5278722at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
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    </dbReference>
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        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
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    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40295" checksum="15DDF6BC0C621146" modified="2020-04-22" version="1">MRLFNKFHAICALAVGSILWSAWFLASQHYYQRVVAANGNEPDFNPATSFERRLVVFGDSWSDNNAGELQGSVWTEWLCSMFQCHHENMAETAKSLRGKYIGSVVDNAELPDSLLNIYKSPLSDFKAQVNQWVAAEARALEELVIDQESISYRQNRTIVVVSFGVWDVWNMLDKGHDTATQSVDRSIGVIVDQLNVLSQSLGTNELKVILTLTPDVTFLPAFRPTGDEHIGRQKDAVQITEYWNGKLREAAEKWDQGTIYLFDTNAFLADLIRDWQLFAAGIEEPNGLGKNQEPGWENVDDACVENGQQLVMTSEVKKCDNPEKYLFWNEMHLGPSAHRLMGTEIFHGIEEMWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJ87</accession>
    <name>A0A5N6TJ87_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_162581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742265">
        <property type="protein sequence ID" value="KAE8146402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJ87"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="86"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="490" mass="54045" checksum="EDEBCCA9634EFB68" modified="2020-04-22" version="1">MTDVPTGGRIVPVVEARQHYSISSADEATVDHQHQPVQAQIPQSQPQQQGNQIPRHQSQSKSTKSTRSKNAETECLELPCLNKLGLYALPTEGDGNCLYYALSDQLFGDFSHADQIRVRLADHIAANREYFMSFIAAVGGERRAPRRAAASAARYSYSSSSSASPAPPSSKDKERSFDSKVAESRKKGVWGGAEEIQAFCQSYKKDVNVYTVYGIQNFRDVHAPDEEEREAIHIAFHDFHHYSSVRHTEGPHTGLPSIPKADEPLKKGASSTGPTVVETASPWKISAIQEGLGGKYDRGAIVEMLQQCRGNIDRAFINLLGEDANTQPSENPTSRAIMKSRFQQSSSRSSSPFSTGSKRSADESELEDNPQPARRNRARAQAQKRRILPDVTVGIAFRDDQNDLVSLRLRVSPDTVAEKPIARPSTEPPSSTSAEPKTDVIGFPEKDKKPRLKPKANSSEPIVPKSETKEEPKPRRSQRLTKSRNAPKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJE6</accession>
    <name>A0A5N6TJE6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_54468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742278">
        <property type="protein sequence ID" value="KAE8146219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJE6"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8146219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="591" mass="66510" checksum="06486125387E6C77" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJV7</accession>
    <name>A0A5N6TJV7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BDV25DRAFT_162125</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="ML742251">
        <property type="protein sequence ID" value="KAE8146622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1210"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1276"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1312"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1096"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1378"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1419"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1419"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1459"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1486"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="939"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1044"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1050"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1070"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAE8146622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1515" mass="170134" checksum="96379EEBF788D189" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK20</accession>
    <name>A0A5N6TK20_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_132726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742247">
        <property type="protein sequence ID" value="KAE8146706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK20"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22812" checksum="A95F6BCB796AF81D" modified="2020-04-22" version="1">MLYNEVLPSNINIIRQITTCSDSSAIFEVDLDGQKFRCELNAYKKLLASGVCARGFVPNFYGYIDQMGSCSISSCFTIFRPRQVKAKSNILLEYLPNAESLNSGVHHQDIYPKNLLLVRGNPNRLVWIDFDVATTFTDLGPKQLAHGDYEIALIKGFVEALRDDQAEGLPPDTKFYQGLHRLLLYISDNISVGAEFQERAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TK29</accession>
    <name>A0A5N6TK29_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_162025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML742248">
        <property type="protein sequence ID" value="KAE8146675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TK29"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000414">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000961">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="480"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8146675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="643" mass="72324" checksum="BE670EC826C79EA3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKM6</accession>
    <name>A0A5N6TKM6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_162017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742248">
        <property type="protein sequence ID" value="KAE8146669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKM6"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="75" mass="8362" checksum="576871D2B4462A7E" modified="2020-04-22" version="1">MLSCWIKAVKNPFATAAIAALFMRDKASSVVDQFEKENQEQGTSSFKDAMKPRKCDDPSAHCKTPRCLKEINAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKN2</accession>
    <name>A0A5N6TKN2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_132531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742236">
        <property type="protein sequence ID" value="KAE8146903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKN2"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="83"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="289"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8146903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="476" mass="52326" checksum="58B25418EBB34E09" modified="2020-04-22" version="1">MERQPRTPADAEKLLALSDLLHRAALTVKEEWAKEDFSGPLTADTPRLLPSSRLWEAQKTIEGIAGTLTELICEPNQRIQQIAPSYFESRALFIVTERRIPDLLAKAGSDGLDINTLADQTGIESRKLSRVMRNLCSIHVFNEVAENRFMNNRISAALAHNEGLCAYVQLYALSIYHASEYLARCLLGPTGASFDVRKTALQESLGIEVPLWEWMAEKIPIDSLCGDGPGYPGIPDANNWAVTGDENGLVNRPELGLFALGMTGGGNAQLVLHMSLVADFPWGELDDGVVVDVGGGVGGFVLQLLPVYPSLRFVIQDRAENVKIGETEVFPRQAPGAISSGRVRFQIHDFFDVNPIKGAAVYWLRGILHDWSDEYCVEILKAIKPSMGPKSKILLCDMVMNTTFGSPEISSAPFPLPANYGYHTRYCHGRDLAVMSIINGVERTPAELKDIVEKAGLQLKKVWEVRSVVGITEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKR6</accession>
    <name>A0A5N6TKR6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDV25DRAFT_46559</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742247">
        <property type="protein sequence ID" value="KAE8146691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKR6"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAE8146691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="157" mass="18153" checksum="A8A38B05D2072759" modified="2020-04-22" version="1">MSLCINRLTEERKQWRRDHPFGFYAKPHRTPQGVLELKRWECGVPGKAQTLWEGGLFKLDVIFPDEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEEEAWKPAITIKQILLGIQDLLNDPNPESPAQADAYNLFKKDRPAYERRVKQVVRENPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TKX6</accession>
    <name>A0A5N6TKX6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_143156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742231">
        <property type="protein sequence ID" value="KAE8147003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TKX6"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8147003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="437" mass="47353" checksum="D8CD1054AA6DE63A" modified="2020-04-22" version="1">MPSTSVALTPGLASFLKSLKTNPIDTSIDNLISLLKRRQIRHSRSCATATAYLLLRVISACRTTDAAKLIERVQSVGRRLVAAQPREMVVGNIVRRVLGLIRDEAEDDREADFNLSEAGSESQPQTPRVPDDHSDSLSGRFEGSDRSSSRPPLSQPAPITMFSLLSHPEPEASLPGTPASASPSGKMLGHTPSKDIRAEVLEGVNEIIDELGQVDDQIAAYALDHIHSNEIILTHTSSTTVQKFLLKAAAKRKFTVIHAESYPNNHEATHATVSGNSTGDDEILSTESFQKPLIALGITVILIPDSAVFALMSRVNKVILGTHSVLANGGLVASAGTRVIARAAKVHQTPVVVVSGVYKLSPVYPFDFDSLIEYGDAGKVIGYEDGDLVDQIDVQNPLYDYVPAELIDLYITNLGGHAPSYLYRIVSDHYRKEDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TL31</accession>
    <name>A0A5N6TL31_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_143352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742241">
        <property type="protein sequence ID" value="KAE8146819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TL31"/>
    <dbReference type="OrthoDB" id="3481287at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8146819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="362" mass="40270" checksum="A3222C6590C1CABD" modified="2020-04-22" version="1">MKNLPQEIIDMIWELIPPCAIRRLLSSRVIEEFWPTMHPTPGSTVVQMCSGNIIIYSTYVLDGFYISGIRIDDKLYGYQNDDTPLTLTIPSPLAALLVTYGQYGMRTIEVLSEPTECLPKSSNTKTQEFLSIIHPRSQPFRVQLTWDVTTNDGRSVALGPYIRPKEFYQTALFTGNVSDILGLYYETFSGSRNLASFGVLGRPGVSFHRPTLHDTTLSPPSDFGHSSLFGRSSLLNVLPPYQAMFSSLASLKDIETIDVCRLGSRCTGMLLTSGKDGHTSVLGQWYEDTSFQVEVSRLDHQLDNILAFTLVGTGQDYYVGKIDSLSASENLTDAQIFIHGARGDKIIWIYSHSSDTILLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLH2</accession>
    <name>A0A5N6TLH2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_161447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="ML742233">
        <property type="protein sequence ID" value="KAE8146959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLH2"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8146959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="971" mass="108605" checksum="1DE5591C5593A884" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLP6</accession>
    <name>A0A5N6TLP6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_160721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="ML742216">
        <property type="protein sequence ID" value="KAE8147273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLP6"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="92"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8147273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="272" mass="30598" checksum="14FFD61788249E9B" modified="2020-04-22" version="1">MSATTTVTAPPRITVENVATLFPDVDTSLAREVLPTASGNPSSGSSSELAGYDKEQVRLMDEVCIVLDDDDKPIGSASKKTCHLMTNIDQGLLHRAFSVFLFDSNKRLLLQQRATEKITFPDMWTNTCCSHPLGIAGETGSELDAAVLGVKRAAQRKLNHELGIKPEQVPLDKFEFFTRIHYKAPSDGKWGEHEIDYILFIQADVDLDPNLNEVRDTKYVSADELKAMFEQPGLKFTPWFKLICNSMLFEWWSHLGSPSLEQYKGEKEIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMK7</accession>
    <name>A0A5N6TMK7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_132006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742203">
        <property type="protein sequence ID" value="KAE8147520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TMK7"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8147520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="521" mass="57007" checksum="D8E60A9623E17E14" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNR9</accession>
    <name>A0A5N6TNR9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_142283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742184">
        <property type="protein sequence ID" value="KAE8147937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNR9"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="48111" checksum="60230BBEBD3B757A" modified="2020-04-22" version="1">MSSNARTISKRPPKLRAACNECHAAKVRCSGEKTGCQRCNNLGLNCVFSISRIGKVPGKRSKANRAAAAAAAAAAVVAVPASSTTDTTLTSPSRIEPSNETVSFQPFPHGIKEEGGSGIIAARQGPSGIAADIKPMMVHDYSSSMPFYTGDGYTPDHMPLPEAMPSSSNNIHHTLAPNLDLGLPEPGFCWASELEHLSTNGLPTPALEVSATRGPLGLDRRLSHDWEMEANMASSSCDAGTSRSCTTSIRQPATPPDYLGDDSMYPIGTFPETSCTVYLQLLHSIEQTLLMNRQRSKETHALDAILAANQQYITTLLQLTENLAFDQLYDGHMLFTVALSKIIMLFSFGYRDFTLRSDTHHCADRLIRFGVFEIDFVEQKAICRSIFLRELRRAKVCLSRLVDALCRENFPYTSGRHERLCEEMQQHLDHLTSALDGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPD5</accession>
    <name>A0A5N6TPD5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_131436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742170">
        <property type="protein sequence ID" value="KAE8148212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPD5"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000558">
        <property type="entry name" value="MFS quinate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="529" mass="58595" checksum="8E798F64F032772C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPZ3</accession>
    <name>A0A5N6TPZ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="24">4.1.2.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Peroxin-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Peroxisomal targeting signal receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">BDV25DRAFT_131246</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32 33">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="24"/>
    <dbReference type="EMBL" id="ML742161">
        <property type="protein sequence ID" value="KAE8148428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPZ3"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000071">
        <property type="entry name" value="2-hydroxyphytanoyl-CoA lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000054">
        <property type="entry name" value="Putative 2-hydroxyphytanoyl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="17" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="13 27" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="27">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="27">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="27">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="31">
        <location>
            <begin position="633"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="29">
        <location>
            <begin position="824"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="30">
        <location>
            <begin position="1031"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00059692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00070390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAE8148428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1228" mass="133606" checksum="8766A26CA5E5D2E0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPZ9</accession>
    <name>A0A5N6TPZ9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_158381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742162">
        <property type="protein sequence ID" value="KAE8148405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPZ9"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000021">
        <property type="entry name" value="Myo-inositol-1(Or 4)-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8148405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37885" checksum="EFD48ADE19EAE327" modified="2020-04-22" version="1">MDPSHPYAKELEIACLTVQRATLLTKRVLEAVDKGALDKSDSSPVTIADFAAQALIIGAIHRAFPEDDIVGEEDSKALRLNETLLNRTWELVSSIHLDDEESEALLYSPSTKEEMLELIDLGARGTCNRENRSWVLDPVDGTATFINGQQYAVCLALVVNGVQRIGVLGCPNLNLETGRMHEDSVDKNGYGHQIFAVAGQGAFTRRMGRGALLPATKLDQKAQITEPKDLDFVDCAASTSSDITAHGRLASYIGAPWPQSTDLWAAQLRYIAIAVGGCNVSVKIPRKAAYRSKMWDHAGGMLIAQELGCTVSDLAGNPVDCGLGRTLAGCYGMIVAPASIHGRLVEGVKQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ00</accession>
    <name>A0A5N6TQ00_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_168498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ00"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="176"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8148367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="36539" checksum="A644B0F69C307F1C" modified="2020-04-22" version="1">MKAVIYQGPHEFTVEERPKPCILEPTDAIVKVTHTTICGTDLHILQGDIASTPGCILGHEGVGVIDSVGIGVTNLQPGERVVIPAINGCGRCVYCRRGMASQCEVTGFAFGMVLDGMQAEYVRVPHAMFSLYVLPEEIDPGVGVLLSDVLPTAYEGSILNGGVGMGSSVVILGAGPVALAVLLLLKKLAGPSQVVVVGRGQSRLGVAKMLGADHVLTCLDGDAQVVKSAKALTGNRGFDVVIEAVGLTEVLETSQALVAAGGTIALLGAHMYKCDLHLESLWLRNITLKTLLVNTSSVPDLLRVVKAGKIHPEVLISHEYSFQDIEAAYEAFKTASKHGMLKVLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQQ9</accession>
    <name>A0A5N6TQQ9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_131052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742152">
        <property type="protein sequence ID" value="KAE8148627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQQ9"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="481" mass="53172" checksum="9C73243FE4B1CCF2" modified="2020-04-22" version="1">MSSVAVAPLHRQICLSTSCKTGHGQPAPMKATEAHDCDHDTVMIQEILQSSPHPICGRQEETLCTHPILTDDGFVSRLTAFHVALVKATVNVVDRWWQDTTAHFPGRMPLEPPVENVLQVPFENSLGIWRPDILLTGNEGSSPGPGFRLCEINSRSPSHAVIRTAGQKHVLQQLLGTGSTFSPGGNMDELLNGVLSLFNAELPIHWVRGRDSLDRTDFIQAIAQKTGLHPRYITIDDLRLEPDSSSITGYALYCAGEGIHPEKVHQVALSLFPDEFALLSGGMLRHLATISVNDFRVSLLVNDQRFLGILLQELDGLVQKQQVLTPNEAQLLRDGIVPTLLPGSPELQQWVQRSRRGDVTKDDYILKAARLSLGHGHLIGEEVPDEQWDRILLSMKEPTIRLDQTTYVLQQFIQQPTFDLLVDKHKMENGSRMIGAYYTINGRFVGLGPWRAGKSKICNFLGGGCTCLYSVIPTGIDPVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR08</accession>
    <name>A0A5N6TR08_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_11883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742146">
        <property type="protein sequence ID" value="KAE8148793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR08"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
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        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="285" mass="30659" checksum="8AF19506972B8BBB" modified="2020-04-22" version="1">MSSEVQPVLVSSREDGITILSLNWPHRRNAIDPIAAKCLFDKLLAFENDPSQKVCILTGVGGTFCAGFDLFHSAASSDGDKKAEYDSKDEGYHFSTPPESAQPSIGPLGPTRQHVKKPLICAIAGYAVGGGLELSLLCDIRVVEEDAVFGIFSRRWGIPLLDGSTVRLQAVVGLGRALDIILTGRSVDANEALTMGLANRVVSKGKALEEAIAIAKQLVSFPQQGMNADRNSCYYSAYDASSFHDGIRQEYEKGKGLLDTKAVSAVTQFRQGAGRHGGYKRDSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRB8</accession>
    <name>A0A5N6TRB8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_157342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742143">
        <property type="protein sequence ID" value="KAE8148875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRB8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8148875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="90" mass="10316" checksum="74B9A771619D95CE" modified="2020-04-22" version="1">MGNTISRILKRSLLWTSAFLPNFPTSQPRLYFPGLILCIQSGFAVLYAELPQDLWKICMDPVSRRCNSYKNRGRSAEECRCLCECYSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRJ6</accession>
    <name>A0A5N6TRJ6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_168257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742148">
        <property type="protein sequence ID" value="KAE8148751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRJ6"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="13"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8148751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="421" mass="47182" checksum="8501EC65FC8118EC" modified="2020-04-22" version="1">MSEKGDLSWSDRKRLIVCCDGTWENSTSDSFQPPTNVTRLSRSISREAVVKEDGVNKRISQIVYYQKGVGTGLLGDKLGGGAIGLGLSSNVRSAYGFLADNYDDGDEIFFFGFSRGAYTARAVAGLVTNLGLLTARGMDNFTAVYNDYYEKNGQSGTKMNYQDGEWRARVGFRLKPLPQFTVRIIGVWDTVGFHDTWLGRMLGEQFEVPGTALSPDVKYAFQALALDEARNTYKPVLWHLPEVNAEQELLQVWFSGYHSDVGGGASDPGLSDITLAWMVSQCTKDNQLAIDLEYFYDRDKMTIREEDSPWATSMGDVNPPKKGITRLLESFKGQSPRTPLQYPGKGTKAMITNEKIHESIRDRNIVSGSKTCHWPCRVVKARESDLSWLLSSGRRIEQLGASRVERELKGRIRRVHPTEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRN1</accession>
    <name>A0A5N6TRN1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_157130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742138">
        <property type="protein sequence ID" value="KAE8149016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRN1"/>
    <dbReference type="OrthoDB" id="4442598at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="637" mass="71243" checksum="5D934575F04B77F3" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRX1</accession>
    <name>A0A5N6TRX1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_168057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742135">
        <property type="protein sequence ID" value="KAE8149102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRX1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF21">
        <property type="entry name" value="LIPASE_THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G02590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="111"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="39244" checksum="D73D7F924CAE96DE" modified="2020-04-22" version="1">MFNTTIPLSFTEKLDFIPAIVSLCLTVLWAMFTGLWRSTSHPKSWLLHVGYAAFRKATARLSVAQMQYVMPPTNKIYERYVRKSQKVADTVDLGHGGLGHWIGDRNADNTLIWYHGGGFALPANLGYFHFFARLIAESARANKSLTVFSLTYTLAPQATYPTQLRQAVEALRYVINETGHSPGQILLGGDSAGGNLVGGVLSHLAHPHPSIAPISLSSGHLRGAIMIAPWTSMETDYTGQDIDSRGDLITPAVAGPWASAYLGTTTRDNYTDLSTAPTDWYTTFPVQKVLICAGGSEILFPIIQDFAKRFKEGFPNVELCVGHREGHVAPIYNLYLGDQTETEQGKRVKSWLREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TRZ2</accession>
    <name>A0A5N6TRZ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">BDV25DRAFT_156953</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="ML742134">
        <property type="protein sequence ID" value="KAE8149126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TRZ2"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000006">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="204"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="901"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="47"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="830"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1036"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="611"/>
            <end position="618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8149126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122838" checksum="54C8F9DD70461069" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSI8</accession>
    <name>A0A5N6TSI8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rgp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSI8"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="827" mass="89715" checksum="35192E9945466B27" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSM3</accession>
    <name>A0A5N6TSM3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_3208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSM3"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="298"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="539" mass="59408" checksum="DE6A66797CA80BF8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSP5</accession>
    <name>A0A5N6TSP5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742132">
        <property type="protein sequence ID" value="KAE8149159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSP5"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="47294" checksum="0AD7367E7FB8D89D" modified="2020-04-22" version="1">MPVSKSEPVAIIGAGVFGLATALQLAQDGYTDVSVFEKDDQVPPRHSAAFDINKIVRPEYQDPWYTELTIKAIEAWKSPLYAPYYHETGFLHLVSGTAPQQAADTRDSFVKTIRHHPRFESILKNINSPEDIKQVAWQLDGEFPGWNGYFNPLAGYAHSADALRGVYKAAAARGVKFFLGDQGDVAQLVYDQNHQATGVMTRSGRYHPAKVTVVAAGAAAATLVPEVGQQVVAKSWSLGHVRLTDEETSMLRGIPVTYARDLGFYFEPDPKTNLLKICPMGGGYINTDPKTGVSLPPSLADSDDVLPPDDERRMRRLLRESLPALADRPFVEKKLCWFADTADSDFIIDYVPNTGSSVVVCSGDSGHLFKMFPIAGQWVHQLLQGDGQSEARWRWKQKSDSKWAGGDVSWRLGQTKEFAEIKVPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT58</accession>
    <name>A0A5N6TT58_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_156205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742121">
        <property type="protein sequence ID" value="KAE8149484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT58"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="208"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="440" mass="50151" checksum="1FA4E8CFB4C53AC8" modified="2020-04-22" version="1">MLKAWAMQRVWCTIGRTSLVKTKIPRVGVRRCHHLTIPGKRTRLEAHQAGHRFDVNRFRQPRTLFTEAIPSILVPPLIFVGLLLALWTWKCFWIVVLQDKLLYLSWLPPLARSEKILEYERECRPVQWLERRIKSLDGTKLAVCEGRIFVPGHNDQTAPTASPTGHRKKSVVICYFQGNGGSTPLRLPLLSQVLRTINETPQPKNVEYTILALSYRGYWTSSGRATQSGIELDAQAFLDWVLETYTTPDTDLRLILWGHSLGSAIASKATATYLSRQHDTHPSIKSTENNTSQHPISGLILEAPSSSIKDMLISLYPQKWLPYRYLWPFSWNHWDCTTAMDRLARWRDHRDTVQGKHESCEVDIPSPRRTIPPILLLSVQNDEVIPPHVADGLEADAKRLGLSLERKDVKGALHTEAPIKLDGREALVQFIFRSTSEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTM8</accession>
    <name>A0A5N6TTM8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742122">
        <property type="protein sequence ID" value="KAE8149469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTM8"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="396" mass="43106" checksum="8E27DC3B7B9D9F16" modified="2020-04-22" version="1">MTAVTCHRHSHGGYLYNGDHNNSNNSRPLHIVQTSLAPTPLAPGTTDTASCLAGSQLSPSLDITSSTLNNLPDTNTATLVLTGITVDTCTSSTKLDPALHDLVDDMSVSEPQDKHTKSTPPSSVSGKSRIPKRKRTVSPPSPSSSSPGGHRRSTSRSTRRSTNTNYQNSVHSHRRAATVTALTPSVPSKDPEIKREDLLALHRESCRLFQDSDNTKSNQPAEPPAPSNVPTAPQDTIPASSEAGSPPVSPVLRTQLSFTSKNPASQNLKGPTLRTSSVASTALDEIYSSPVHTSATVIDWTSPSTRRREYKKIDRASSGVRGFWRRVAPKWCQSRQDRTPFFEEKDGKGNYEGSVRRFRMDLPDDPVPDQKLSAIRGLKLKQKLATSKMSNRRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUH3</accession>
    <name>A0A5N6TUH3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_172486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8150012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUH3"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024828537" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8150012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="615" mass="67414" checksum="4749896F7F49DC8C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUT4</accession>
    <name>A0A5N6TUT4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_120903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742111">
        <property type="protein sequence ID" value="KAE8149841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUT4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19122" checksum="A787D4AC4D1BF81F" modified="2020-04-22" version="1">MHRRALELRQKVLGPEHPDTLVSINDLGWSLARQGSYGEAEKLHQQAFKLREKVLGPSHPETLISMKFLGLVLIWQKKYEKGEKIYRSLTEEQERTLVPEHPETLLTMIELHKCLYNQGVYNEAEAIIRQVLERQRKVLGPDDSWTLESERDLDVVLRAAQADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUW7</accession>
    <name>A0A5N6TUW7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_114925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742101">
        <property type="protein sequence ID" value="KAE8150158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUW7"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="300"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8150158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="469" mass="52373" checksum="360F016836FEBA9F" modified="2020-04-22" version="1">MLGLTTRRSNMVRSKCLTSGSCHVLRTKAAERSSQPYLMYKNFHSTEPTADSRPTWMPMRVKTPWIEALTKSREDANLSKGVPESVAEPDLTPKKMSDSYYSAILPLAQDKWLLDTYLNATGHIRLGSLLMDLDALAGIIGYKHTGDSVTNVTAAADRITIEHPLMEICDLELSGHVTYATGRSSIEVSLQVAKAPPPGQQAKPEDVLITCAFTMVSLDPATKKPVNVAPLLVETEEERLLFKKGEENYQAKKALRKRSLLQKAPDDEESNLIHSMWTKEMSYLNPENPAKRPSNMIFMGDTVLKSAMIMQPQYRNRHSFMIFGGFLLKQTFELAFCCAASFSHARPNFISLDPSTFENPVPVGSVLYLRATVAYSEPLEREGLGSKYTKVQVRVDSKVRDVEHGSKRSTGQFNYTFLVEKDIQVMPKSYGEFMLWTDSRRRSQNAAAITPDGSGELNALRGLKDSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVB5</accession>
    <name>A0A5N6TVB5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVB5"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="642" mass="71998" checksum="54035B37575EE867" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVR7</accession>
    <name>A0A5N6TVR7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="15">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_112371</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="15"/>
    <dbReference type="EMBL" id="ML742095">
        <property type="protein sequence ID" value="KAE8150387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVR7"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="279"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8150387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="478" mass="54239" checksum="2454D063E20C2CF7" modified="2020-04-22" version="1">MASSDIEAATALKVQGNKAFAQHEWPTAVDFYTQAIEKYDREPSFFSNRAQAQIKLEAYGFAIADASKALELDPAYTKAYWRRALANTAILNYKDALKDFKAVVKREPGNRDAKVKLADCEKLVRRLEFEKAIEVGDPPSAFEDLDIDSMAVDTGYDGVRLENEMTQEFIDDMIERFKKGKRIPRKYVFQIIKAVKDLVYAEPTMVEVGVEQGKKLTVCGDTHGQFFDLLEIFRLNGYPSDTHSYLFNGDFVDRGSWSTEIALVLYAYKWLRPNGIFLNRGNHETDDMNKVYGFEGECKAKYNETVFKVFSESFSALPLATLIGNKYLVLHGGLFSDDNTSLDDIRKLDRHNQRQPGQQGLMMEMLWTDPQTEPGRGPSKRGVGLQFGPDVTKRFCERNGLEAIIRSHEVRMEGYEVEHDGRCITVFSAPKYCDTTENKGAFINVGPELKLDFQVFEAVPHPDIKPMAYAQNSILSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW17</accession>
    <name>A0A5N6TW17_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_154055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742090">
        <property type="protein sequence ID" value="KAE8150575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW17"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34502" checksum="D23238E85A733232" modified="2020-04-22" version="1">MTTQETPYLDALQRDGFVRIPSLLSPEEVAQFRDVSTQATTFTRTGHWPHFRTVPKQFPPWPTTPPPASEGGIWGVQHLLHPEMPGRAEFARFYFSEKVLAVAEELLGVKGTSGDGEPLVMELFNLLVAPETKDFELRWHRDDIPETASPEEELKLLHSKSPQGKQSHAQYNLALCPDASLIVIPGSHRRVRTEVERNAAPYEPELPGQLIVELQPGDAVFYDSNILHRGVYKGKPEGGQETRLTLHGSIGLKGVPADEADKKVRATAVLQHGVGAWVHRDDAAFGIGERPEKMRANLVAMGTGEGVGFSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW23</accession>
    <name>A0A5N6TW23_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_129718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742099">
        <property type="protein sequence ID" value="KAE8150251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW23"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8150251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="35880" checksum="073F2FB083C50DD6" modified="2020-04-22" version="1">MPSPPLLSTRHTGLSGRTYTVEHVLQEEVSPPRQVCRASADGHNFILKYIHPVNFEDLQEVNNRLRNASHVRLAVDTIPDKSMFVFEHFTDHLLTLAQKDLPLVAIKGILKNALTGLAELHDRDIVHTDIKPDNIFINWRNLNNEIRIDKVQLGDLEDAAHIPPGCDMIGKQAGNWMWRSPEAHARGPVNKPSDVFSFAIVCICAVYKRIIFAVQESELEEGVDPLAIVVERQISYFADEDGLNGFLKYLGDNPWVRVFEVTRDRFNQETPREPFAFWNGVDDEFKSLVCAMTNFDPGKRITARQALEHKWFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW44</accession>
    <name>A0A5N6TW44_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoprotease family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_129680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742098">
        <property type="protein sequence ID" value="KAE8150271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW44"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1204" mass="132848" checksum="5009C869981EBF3C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX12</accession>
    <name>A0A5N6TX12_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_139358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX12"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="543"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114982" checksum="9D14D69A50F6EF8D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXE5</accession>
    <name>A0A5N6TXE5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BDV25DRAFT_153485</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXE5"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="537"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8150980.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="742" mass="83365" checksum="EB0F73894B1A0D49" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXK1</accession>
    <name>A0A5N6TXK1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_153231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="ML742078">
        <property type="protein sequence ID" value="KAE8151118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXK1"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8151118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="35433" checksum="AD602D7A05131736" modified="2020-04-22" version="1">MSSSLEQLKASGTVVVCDSGDFATIGKYKPQDATTNPSLILAASKKPEYAELIDAAVAYGKKNGKTVDEQVDATLDQLLVEFGKKILEIIPGKVSTEVDARFSFDTQASIDKALHIIKLYEAIGISKDRILIKIASTWEGIKAAQVLQSQHGINCNLTLMFSSVQAIAAAEAGAYLISPFVGRILDWYKAAHKRDYTAQEDPGVKSVESIFNYYKKHGYNTIVMGASFRNTGEITELAGCDYLTISPNLLEDLYNSSAPVPKKLDSANAASLDIPKKSYINDEPLFRFEFNEEAMAVEKLREGISKFAADAVTLKDILKQKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXU6</accession>
    <name>A0A5N6TXU6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Hydroxyethylthiazole kinase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDV25DRAFT_171669</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742077">
        <property type="protein sequence ID" value="KAE8151140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXU6"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000042">
        <property type="entry name" value="Probable thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAE8151140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="522" mass="55110" checksum="5CCF7ACAA73F9D30" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY79</accession>
    <name>A0A5N6TY79_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_152791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742073">
        <property type="protein sequence ID" value="KAE8151336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY79"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8151336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="51964" checksum="97A1A070B746EF23" modified="2020-04-22" version="1">MDEFKIIIAGGSLVGLTLALVLEKAGINYELFEKGDLMPQLGASIGLHPHTLRILDQLGVWADIEKEVIPLQHRFHFDGSGHCFEASEVLHNIQTILGRPIIFMERRRALEILHSHIHGKSRLHANNAISSYDELEDGVVVTTQDGLSHYGSILIGADGVHSRVRTLMAEKMSKTDLSLSQEIIRGFTSEYNCIFAVSRNDPSHPFIPDGTVHNVYYDNHSAIAAAGVPGLVFWFLFVKTGLTRTPNCPRFTDDDADALIEEYATVAPGPSYTIKDLWQARVKGMLVPLEEGVLKQWSHNRVLLLGDSAHKATVNPGLGGNLAYEGIAHFANTLVELLIEHQNPSQEKVSELFAHMDQIHRSRAETVTKLSGQITRYETQDNWFLKFASRCLVPWVSDNAKAKAYAAFSDGAPWLRFLPLPEQDADLAERKVTRGKASALQYPCVSLFAMGTLGVGVIAMWYMRAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYN4</accession>
    <name>A0A5N6TYN4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742071">
        <property type="protein sequence ID" value="KAE8151447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYN4"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8151447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40765" checksum="50D8FA27A4AE562B" modified="2020-04-22" version="1">MENMQILTNDTIHELLINLTKDEANQFRTTIEQTLQDFSIGQERQYQPDPNAITRPNGQRTLFRPFTSDTSVGAKIVVEPAPAPNGKKDPLHGLIILMDGKGNPTGVLSAEEVTGYRTSMNAMVPFCWRKDVDNIVIFGGGVQALWHARLILTLRGDEVKTITFVKPFRDRVDVLIATLSGENEARWRSSCSFHFIDTVAGDFEERIQECLSEADCVICTTPSKMPLFPAAYLTKRDGARQPFISAIGAWQSDMIELDPALLHHAIAAEGGFNPATAEGRGVVLVDDRDFALHNSGEVVQSAIAASDMVEVGQIVGLRSGKTKPVNPEHVERANKFISQGFVVYKSIGVGLTDLTAANAVLALRKKKEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYP8</accession>
    <name>A0A5N6TYP8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable Xaa-Pro aminopeptidase PEPP</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Probable Xaa-Pro aminopeptidase pepP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_128751</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="ML742070">
        <property type="protein sequence ID" value="KAE8151503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYP8"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8151503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="51834" checksum="F00A181B4DD0F920" modified="2020-04-22" version="1">MTTMDAILAGKYPAKSHARRVAELLKEHEHDAPSIIYLEAQKTRFIEDNDESMPFRQRRFFYYLSGCLLPDSCLIYDVNADKLILFIPPIDPEEVVWSGLPLSQDEALKLYDVDTVLATTEVNATLASIASTYGANAAAFAIADQVSNGIKFQGFARTNLSVLKGAIEKSRVIKDRYEIALLRKANDISAKAHIAAIKASKTALNECEIEGAFIATCIANGAREQSYHPIVACGENGATLHYGKNDDGLIDPATKIRKKNVLIDAGGEYRAYCSDITRVFPLGGKFSMETRQIYEIVLQMQTECIAMLKGDVQWEDVHVHAHRVAIKGLLGLGLLRGSEDELFEKRISVAFFPHGLGHYLGMDTHDTGGNPNYEDKDSMFRYLRVRGRLPAGSVITVEPGIYFCRFIIEPFIKSPELSKYIDTDTLERYWGVGGVRIEDNIHVTKEGYENLTTAPKVIEEVEALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYQ3</accession>
    <name>A0A5N6TYQ3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_128681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742069">
        <property type="protein sequence ID" value="KAE8151508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYQ3"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25581" checksum="2D9942C151CC84C0" modified="2020-04-22" version="1">MGPQGDCLLDLDLCDIVIEREISRSEASTVFKVQICGKTCVMKLYYDNGDPGYSKRGRDLNCFCCELNAYCNLLKFGVCGSGFVPFFYSFIDCLNPSNFGQQLNHFRKDKYFLRVIILEYLPVAEKLNCVNYSDELFHYVLEGIKEIHRALIHHYDIYSKNMLVVSCSRIVWVDFDVAMTFKDMGIREKAYCEYEVGLVKSFGKKLKNDKLRGLLPNTTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZN8</accession>
    <name>A0A5N6TZN8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative Formamidopyrimidine-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_85246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742063">
        <property type="protein sequence ID" value="KAE8151837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZN8"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000004">
        <property type="entry name" value="Putative Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="372" mass="41781" checksum="927437F2118C5FAE" modified="2020-04-22" version="1">MPELAEVSRIVHFIRQHLVGKSLSKVSTQNDDIIYGKAGTSAAEFQKAMEGKKVVGAGQQGKYFWIAMSSPPHAVMHFGMAGWLKIRDADTYYYRTDKPADKEWPPKYWKFLLETDGDPTTEAAFVDFRRLGRIRLVNCPEDQIRKHSPLKENGPDPVADKDVVTEDWLAAKLRSKKVPVKALLLDQANISGIGNWMGDEILYHAKIHPEQYSNTLTDGQAKELHSAIHYICSTSVDLLADSEKFPEDWLFKYRWAKGKKTMPTLLNGEKITFLTVGGRTSAVVPSVQKKTGPVAKEVKGEEESEAQNNTKRKRGAAVKKESDAEQSEEEPKIKKAAPKGRPKKIKEASDEKKPEVSEQPPAGRRRSTRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U047</accession>
    <name>A0A5N6U047_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLAC8 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_151890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742061">
        <property type="protein sequence ID" value="KAE8151983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U047"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="138" mass="15486" checksum="87FB01F1ED97E33B" modified="2020-04-22" version="1">MSNPDHKHNEWSNSFWDCCSPFGTCCMSFWLPCCLHGKTHSRLDDPYLKEHSYCNGSCCLYTLTSYIGFHWVPLMMQRTKIRQRFGIDGSGCGDCCSACCCPCCVMMQNEKEVEVQCSRMGGLPGGYQAPGGMNYSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0C9</accession>
    <name>A0A5N6U0C9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TAP-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_77913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0C9"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Nybo J.L."/>
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                <person name="Lyhne E.K."/>
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                <person name="Wiebenga A."/>
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                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="347" mass="37583" checksum="F31401A13E33E874" modified="2020-04-22" version="1">MRSRQIINPVSPSARFVSTGVGYPRKASASQSPLAQETRPGPYAVAPGSPLPGDSMTGHPTPVSGYQQPVPVSVHSTPTFHSRRTSANPTPNPSSQETSPTTPISAFSQFGRASPAVSAAPLPSGPQSASSFVHSASHSAMESNNRLPSVAGNRSVGDDSAVMAGSQTENPPYPGMIPCILDLKSGSSSQAEKRKANSDASRRFRNRKRNEMQMEQKIAAQQDEIRKQTEALQRQIQEIQRLSSECDFYRSERDFYREHVSRLVPPGQLPTRPASPRTLRPSFEKATVERDHQTWAAQDSAQRVVDAAGVPAVSATRAAGSWTTRGTLADEQQARALPQYPRSWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1X5</accession>
    <name>A0A5N6U1X5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_127874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1X5"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8152542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="224" mass="24957" checksum="C3847A3ADB3B272B" modified="2020-04-22" version="1">MPLPWRVLAGTLATGGVSIGASFFYMTHDIQFVPLSSSDPIFLSIYHKKSNPNGNPTIRDLHVKRVPLSKIDPTLLEHPQKLLERYCGGVWAGGGFTPQRLALAWFDRDESTSQLWSRSELIQSEYTVGTDIVGNFEVIDRSKESILIRGGDRTSNQGLRPLDGLIEVTVHIEKEQDVAEFGFKSLFFQGVGTTDQLPMPGPAIWLHEQYAKALLRSGVQHVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U224</accession>
    <name>A0A5N6U224_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_170228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742051">
        <property type="protein sequence ID" value="KAE8152570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U224"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8152570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29039" checksum="A949DAC29DA7E662" modified="2020-04-22" version="1" fragment="single">MTQLLTGKVAAITGGLTGIGRAIALEYLRHGAKVSINHLGTPNEDQLLTDLQTAVNNTPTSTSTSNPSTGSSTWEESFLTVAGDITHPETGKEFIGKTVEKFGRLDIFVSNAGVCRFEEFLEVDPTLLNNTITTNLTGAFYATQSAARQMALSQSPPGGSIIGISSISALVGGGLQTHYTPTKAGVLSLMQSCAVALGKYNVRCNALLPGTIRTQLNEEDLSDEGKRAYMEGRIPLGRLGVPRDLAGPAVFLGSELSCYVSGAQILVDGGMFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U294</accession>
    <name>A0A5N6U294_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase get3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_127766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U294"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="339" mass="37433" checksum="E2E8BC7F45A42394" modified="2020-04-22" version="1">MSAAVVQADDLMEPSLQSIVSQNTLRWIFVGGKGGVGKTTTSCSLAIQLAKARKSVLLISTDPAHNLSDAFGQKFGKEARLIDGYTNLSAMEIDPNGSIQDLLASGEGQSDDPMAGLGVGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGSRGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYKIDTHAIVVNQLLFPKQGSECEQCNARRKMQMKYLDQIEELYDDFNVVRMPLLVEEVRGKEKLEKFSDMLIHPYVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2E4</accession>
    <name>A0A5N6U2E4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDV25DRAFT_127736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IBT 18842</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1291"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="732"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="685"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAE8152756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147060" checksum="4E71178CC30731BE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2P2</accession>
    <name>A0A5N6U2P2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_150339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742046">
        <property type="protein sequence ID" value="KAE8152885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U2P2"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="410"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8152885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="698" mass="74862" checksum="FBC45EFFD49BA64D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U337</accession>
    <name>A0A5N6U337_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_169766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="ML742045">
        <property type="protein sequence ID" value="KAE8153006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U337"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8153006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="324" mass="37347" checksum="69841E2804B45A50" modified="2020-04-22" version="1">MADQEVDLDSIIDRLLEVRGSRPGKQVQLLESEIRYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQKYVYGGMSSNRPVTPPRKQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3B3</accession>
    <name>A0A5N6U3B3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_150157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3B3"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="316" mass="35436" checksum="E83DF2AD539F7D20" modified="2020-04-22" version="1">MSQAGAQQVLFRTGIAAVNSQDHLRVYFQDTQGGIRETMFEGSTWSNGTEKNVITRAKLDTPVAATSKKLEHIRVYSLNQENMIQERCYDAKSGWYDGAMTRAKFQVAPYSQLGSIFLAGMEELHLRIYAQKPDNTIQEYSWNGKEWKEDTNLGPALAGTGIGVTSFKYLDQKGPSIRVFFQTPDLKLVQRAYDPHTGWYKELYTIFDKAPPRTSIAATSFGASKDGIYLRIYFVNYDNTAWQVSWDHGKGYWDKRSITPVVPGSELAIISWGSFAQGGPDLRMYLQNGTYVSAVSEWMWTSAHGSAMGKDALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3C7</accession>
    <name>A0A5N6U3C7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_137304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3C7"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="95" mass="10372" checksum="08037DC47F8E5682" modified="2020-04-22" version="1">MSDLWVLSSDGRCKIFDKHADGYVRREAVYELFLKDLDHALRDRDHIRATVRATAAGSEGNSGPGIKDLSQTAFVECYGTVTAIGDVVEATAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U410</accession>
    <name>A0A5N6U410_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_150065</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U410"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="61"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="251"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8153159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="400" mass="44362" checksum="042EAD6B73A5164D" modified="2020-04-22" version="1">MASRGLPRALRLARVAAPRSVVSAALPRPALAKAAANAIPRVTLSSSPVRGVKTMTFADSQETVYERADWPREKLQEYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKDGASWKEAVQDGWIPGKNLFDVNTAVEKGTIVMNLLSDAAQSETWPALKPLITKGKTLYFSHGFSPVFKDLTKVDVPKDVDVILVAPKGSGRTVRTLFREGRGINSSIAVFQDVTGQAKERAIAMGVAVGSGYLYETTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGGNGMDWMYAACSTTARRGAIDWSSRFKDNLKPLFNELYDSVRDGSETKRSLEYNSQKDYREKYEKEMQEIRDLEIWRAGKAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4G5</accession>
    <name>A0A5N6U4G5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_149233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4G5"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="133" mass="15242" checksum="9C89EFE0FEBEC844" modified="2020-04-22" version="1">MQTRHTKHVYHPTIWEYLSWYPRGVWYLQFITMSGRMDTKCSSLAPVPVPSREGSECMVNFFPWLLQGVSLNYKVGTIISPPFAVLIAYIGIIRRRGELEVISLFLAFRRTCDCGVASFIDLKHINGLSSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Y1</accession>
    <name>A0A5N6U4Y1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_17958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Y1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000032">
        <property type="entry name" value="Probable aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8153656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="473" mass="51473" checksum="B497A9F0F3B5A327" modified="2020-04-22" version="1">MTLDITTFFNVINNELTTTVATRHGINPATRQPNPEVPLSTAEDLDRAVAAGRQAFKKWSRTSYEERRKALSAFADAMEENKDVLAQLLTQEQGKPLTQAAFELQAAITWARTLPTLTLPEDVIEDKEDCKIIHRYTPIGVGGAIVPWNFPVHLAVGKIVPAVYTGNTIIVKPSPFTPYCDLKLGELAARCFPPGVVQVLSGGDDLGPMMTEHPGVDKISFTGSSATGRRVMASCAKSLKRVTLELGGNDPAIFCDDVDIDAVIPKAGMLSFMCSSQICMMIKRMYVHEKIYDEFRDKLVEHVKNFKMGAGTEEGVFLGPVQNSMQFGKAQNLMGSIATEGLNPALGGSIPDSEGYFIPATIVDNPAETSRVVQEEAFAPILPLLKWSDEDDVIARANKTESGLGASVWSNDLDRARRMADQLEAGNVWVNAHCEVTPMTPFGGHKASGIGCEWGVKGLTGWCNSQTLWVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Z1</accession>
    <name>A0A5N6U4Z1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_18297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Z1"/>
    <dbReference type="OrthoDB" id="4691311at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930566" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="104" mass="10595" checksum="E7070923CBCB9D10" modified="2020-04-22" version="1">MQLLTFLLTALVGSTLATPSGEAVGTLAQRACGSKYNSCGAPHQPPCCQGLSCAAGTCLPKAARGLDRFERRACGSENYPCGAPLQPACCGGLYCTSNTCLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U552</accession>
    <name>A0A5N6U552_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_18286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U552"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025074739" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8153704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="532" mass="57638" checksum="A40DE5D6F8AF2C30" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U567</accession>
    <name>A0A5N6U567_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_136672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML742036">
        <property type="protein sequence ID" value="KAE8153736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U567"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="109"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8153736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="28740" checksum="A4F96DA7F1E137C2" modified="2020-04-22" version="1">MAPNHAKITLYWLEKSRSQRIVWLLEELGVEYNLKTFQRNAEMLAPPELKQIHPLGKSPVITVETDSMEKPLVIAESGNITEYLCDHFGGDKLIPPRWKEGQEGTVGGETEEWTRYRYFMHYAEGSLMPFLVMQLVMDRMKDAPVPFFVKPIPRFVASKVEEAFLTRNIVGNFDFLEDQLKTAPKGGPYLCGPTLTAADIMMSFPVIAASLRVPLGDQYPHLVQYVALLQKEDGYQRAVKKVEEVDGKFEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5M0</accession>
    <name>A0A5N6U5M0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_168744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742038">
        <property type="protein sequence ID" value="KAE8153501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5M0"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024962019" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="57473" checksum="BD37031D93E1ADFE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5W8</accession>
    <name>A0A5N6U5W8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8153972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5W8"/>
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    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8153972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32048" checksum="A2A886FD1E62E6A4" modified="2020-04-22" version="1">MPSIPALVRALYAVALLNLSTAAAVSRPRPIYAVAHRITETEAVPIALSHGANALEIDLTSWSLGWLSDNDDPFMSTGSSARELFETVASQRKSGSTVSFVWLDIKDPDLCPEGRPCSIEALRDLAREILQPAGIRVLYGFVHARDSRGYQVIRDSLNANEAIAVTDKTHDVLEWYKRNGGSVPVKQRVMGYRSPQLDRTDANLHSELRYATWARGQGRLGKVFAWMSTHGSAKLVAHVMSEAAVDGFIYGHPAAEYNDGNGVKSTARQIIKYVESHSDTMRMATNHDSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U687</accession>
    <name>A0A5N6U687_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_172579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="5-keto-4-deoxy-D-glucarate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="271" mass="29440" checksum="2311E413C1BE2112" modified="2020-04-22" version="1">MTVQTETYRTPQTTEIANSRLRLLNKIKSGEFPLMTFMALPSVRMAQIVALTGLDGIIIDCEHGHISDDSMHNSVSAIAALGVSPVIRIRGPAHDIIKRALDTGAHGIMVPQINNADEARQIVASAKFPPYGVRGQGSAFPAIAHGLTTPEYMLSANETIITMIQIETREGVKNVEEICAVPGVDLVFIGPNDLAQSLLGYVPARGDEPEFVEAVDKIIAAARKHSKWAGRMVNNGSMAKEARKRYDTVAITGDTKAIQNWYMAEFEVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6P0</accession>
    <name>A0A5N6U6P0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_148131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6P0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="51" mass="5882" checksum="3563406C52393476" modified="2020-04-22" version="1">MHAIVLLFLRPRLSYLPSLFAFFATTLLSTISLFVTCNESFPETRQYKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6Z3</accession>
    <name>A0A5N6U6Z3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_172375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6Z3"/>
    <dbReference type="OrthoDB" id="3021074at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="466" mass="52998" checksum="3562F6C999882705" modified="2020-04-22" version="1">MNPANESPLFVAEEVLCAYPISTLYDSCPRYLFYALLLATCVTRWTGWLADVFLGAAATYAGTAAIQSFILVSSIPKHYPSQPVTIPFVSDNTTLWDRFPALVTGVDEIDISPASLELDADAVLSIVVTGYLVFLPLQCWSRTFANDRIGYILFSLWNILMLAGSICSLVYWPTLKKTPSQYAFCFPELPPSSSSTNDGWGSWARTSTWNSSVWSIFQNATLFDQIDDICFYPCFNTTQILRQPTSLQAAVSAENRFTKRHRFWDKVIYSQRYIYSLVALSVALNFFMLLIKLLPYRSRVPSSRVWHIWQERKNILDGFKRDFRTAIHATQHGREHMMDETRKRLSSSKLAPGLFTLRALGSWAKLTVDVVILIALVFSIVTSPLTVIAFVAWIEYYIHNDGPSAEKPQQVGQWSPLVSIAFLMVSAAILKLKYRVAPRQEIDHDIEELREKLNRLESLRDKERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7L5</accession>
    <name>A0A5N6U7L5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7L5"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025025787" description="Altered inheritance of mitochondria protein 6" evidence="3">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="337" mass="37486" checksum="722F2C6FBB8AD330" modified="2020-04-22" version="1">MCIAAFSWPSSVGASFAWFLLGMVLAERLTPPVHANGLERIRESWKIPSDSMTALSPWPKDFSQGITPVQCLSHNDYWRSVPLFDALAAGCLGVEADVWLDETANDLLVGHRASSLSSDRTLQSLYITPLAEILTRMNQGRDLGRSGVFETVPSASLTLLIDIKTDGHTTWPVVMDQLAPLRAGGWLSYWNKTDGKLSQRPITVVGTGNAPFELITADPEYRDIFFDAPLDQLADNTSFTAENSYYASVSLKKAVGTIQPWGPSRSQREIMKRLIETAAKRGLVSRFWDIPGWPVHLRVKLWRFLVESGIGTLNVDELVQATQWNWDWCVVAGFVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7T3</accession>
    <name>A0A5N6U7T3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_136098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7T3"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="36972" checksum="820A92D192F3675B" modified="2020-04-22" version="1">MSSLVPGYIIQGARWDYRNLEHVKGYNTHTSNVFKAEIVQRTNSSSNALKSPQWALIKEASSSDAISMENMNRECQVYDLPGVNTAKCFRQIYDVIDNRTIALEWLDTTLADVQYHPNARRTYSLIVAVLRAGLTSCILLERHKRVNTDHKPANILLSGIDTGHVTAKVGDLGLVVPVGSLFNAQPYAMRAPEVFLGQACTEPSQVWAVAALLLCWIKPGVLGTWKSPHPLLREAWCMAKIKRLFPDWNIPTSDEVGSHSLKAAVDSASYFSKELIDLRAISPFGEETQGVMPRELRDLLRSMFVANPVERPSASAVLASEEFRAFERLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U838</accession>
    <name>A0A5N6U838_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_147396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U838"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="444" mass="49339" checksum="C6E566B85EE8AF60" modified="2020-04-22" version="1">MAVADYKRYLAENVLNERRTVTYRLLSRALRVHSTLAKQMLYDFYRNENNKRPQSVNATYILTGVPKPAPAPTNGHANGDSMDDDIPPSSPYLSSSMPNQDTMPDNVTTASVLLVREEDLEDAKSTLQSISSVYIYSLQPAVLQDLNVLTDVCREVVDNHAQEDPLEYGKQWGMIQNKNVKRRTGARPPAPPPAAAPSATKPTIPSKRPSEAPAQTQPAPKKEESVASEPSSARENTPSAPKPTEKTAPKREKSNLFSSFAKAKPKQKKESQISAESAEPSGGEGAFLDDEFDEEPEELFPDSKKSTTADATSRETRKEREEKLKKMMEDDEDEEMPDVAEPQKEEEEKEDESKPIDQPPPKQPELKEETTVQGGRRRGKRQVMKKKTVKDDEGYLVTVEEPSWESFSEDEPAPPPKKKPTVSAPKGKPAGKGQGNIMSFFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U877</accession>
    <name>A0A5N6U877_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase M</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDV25DRAFT_103228</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U877"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025002909" description="Probable beta-glucosidase M" evidence="19">
        <location>
            <begin position="20"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="691"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAE8154609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="768" mass="83272" checksum="8C5DBB7E1F0EBDA9" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U886</accession>
    <name>A0A5N6U886_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_136014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U886"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="583"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="619" mass="66564" checksum="B0B5514F282A8380" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8A0</accession>
    <name>A0A5N6U8A0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_135505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8A0"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8154863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="268" mass="29557" checksum="65484C97888DDA68" modified="2020-04-22" version="1">MSWKDLNRHTRILRDAETGHYGVIAAIAYNIEQVLGLVRAVETARSPLIIQFFPWAVEATDGLLVRTAADAAERASVPISIHLDHAQSETIIKRAADLPFDSIMVDMSHYEKDKATEAEPGRIEGGEDGVMDTAGLEACMTTAEEVDEFVDTGVDVLALAFGNVHGEYGSRGPLLDFDRFEQVRLRAGGRVRLALHGTNGFAPELMERCVQAGVTKINVNRLVLDDYYDHLRANVDRMPHTQLIEEGIQKVADLTVRWMEICGSAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8A9</accession>
    <name>A0A5N6U8A9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_82613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8A9"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="345"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="545" mass="60683" checksum="F34B4431A24F5ACD" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8D1</accession>
    <name>A0A5N6U8D1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_135538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8D1"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="7">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="648" mass="71366" checksum="E873543C0D67082D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8K5</accession>
    <name>A0A5N6U8K5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_146761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8K5"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="163" mass="18374" checksum="FF6BEBCBD3423D75" modified="2020-04-22" version="1">MSFNSKNLAYDAKEPAFLQRLKNQYGDTSGRLERPIARPRLAKNNNDDDDEPTYVDEESNEVISKEDYEALVRDSNKETEGSMKDASGQGQSNREEDKGSAEKEASLPKQNIAEIGGPKKRKQAKLIGEEDPPPEREEKSSNDTGSRKPKQKKKKIKLSFDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8N6</accession>
    <name>A0A5N6U8N6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enhancer of mRNA-decapping protein 3</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BDV25DRAFT_126145</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8N6"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1263" mass="137102" checksum="76DFF5F64A80216D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8Q8</accession>
    <name>A0A5N6U8Q8_ASPAV</name>
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        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_135352</name>
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    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">IBT 18842</strain>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8155015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="492" mass="53946" checksum="58429C934152BE49" modified="2020-04-22" version="1">MKQLGILRTLTVKLLCAICSFGLLGMARGLDEGLISTTVAQQSFISEFHLRDTDLDASEKANRLSNITSMVHIGCIPGALVAFLLCEHIGMLWTMRQLCVMWMAGVIIVITAAGRLGQIYAGRFIMGMGIGQAGVVAPVYLSEVATPSLRGLLVCTFATSEYLGIMIGYFSSWGTTLHISDSNAKQWIIPQSIQIMMAGILLLVSFSCEESPRYLCKTGRFDEGTLALSRLWNLHPFDPHVQAELNSIRTQVEREHSESSTQRWRRALKSLVTESSNRSRLVFLAITQVLSQWSGANSITTYAPELFSILGVTGQSETLLRTAILGAVKLAASLACTVFLIDYFGRKRPLIVGILTQLVAMLYIALYLTLTSSTNTSQSKSEHHAAIVAIVCLYLSGVGWALGWNSVQYLINAEIFPLSVRAVGSSLLMCFHFANRYGLSKAVPSMLLENSLRPEGTFWFFAAVTLLGLLWVILRLPETANKTLEEANALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8R8</accession>
    <name>A0A5N6U8R8_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_170327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8155002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8R8"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="370"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="650"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="857"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8155002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122816" checksum="C51F09170515860F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCN2</accession>
    <name>A0A5N6TCN2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_172216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742761">
        <property type="protein sequence ID" value="KAE8144144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCN2"/>
    <dbReference type="OrthoDB" id="5413281at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="243" mass="26580" checksum="98150CCBE5723B57" modified="2020-04-22" version="1">MELSDTRETLLPSFVQFVEGLISQLSSCTPDPRVEINGRQSPQTLPATDPKSLMLTLHCLFPNELLPALDILDRGLVRRYVEKSHGIRPSVASGTNKPGRLAPRDDIYFVISTPQVPPASSAGCPATISSPVHHGGYEVRLHAWNCSCPNFTLAMFRDQDPDFPENNFEFPLVPEVSTSRTSYPFGGNLTRQLTRPSLPVCKHLLACVLMVRCPELFGSLCSGDSQITIGANEIAGWCAGWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCV3</accession>
    <name>A0A5N6TCV3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_167495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742708">
        <property type="protein sequence ID" value="KAE8144173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCV3"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29547" checksum="ADBF8B1F1F42009A" modified="2020-04-22" version="1">MSAEDQVQLSDFSSIFSLDGKVAVVTGGSRGLGLHAASGLLQAGCKKVYITSRKPEACVSAVTALNALPNKRPDAIAIAVPADSSQMSELDRLVAEVQKTTDHVDILFANAGATWGEKLETHPEKMFSKVVDLNVKSVFYTVQKFAPLLTAKATLEDPSRVIVTSSVAGLIVSSVGPQATYGYAASKAAVTHLTKNLAVELGPRHVLCNVIAPGFYPSKMADSFIEMTGGVKAQEQRSPNKRLGRPEDIAGLVVFLSSRAASHLNGAVITSDGGSHLKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCV8</accession>
    <name>A0A5N6TCV8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742651">
        <property type="protein sequence ID" value="KAE8144218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCV8"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="65" mass="7359" checksum="1A87F35AE37EA31D" modified="2020-04-22" version="1">MSGLRSLNILLLSYRSREVTMLTLIAQMQFIAFSIPTLICVNIDFLGTQARKEQGLIRPCTNMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TD99</accession>
    <name>A0A5N6TD99_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_97273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742550">
        <property type="protein sequence ID" value="KAE8144365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TD99"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000053">
        <property type="entry name" value="Probable translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="13">
        <location>
            <begin position="518"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8144365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="704" mass="78399" checksum="03ED4EEFC7008394" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDA7</accession>
    <name>A0A5N6TDA7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_103892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742622">
        <property type="protein sequence ID" value="KAE8144250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDA7"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="468" mass="52708" checksum="87BB09D6F0C442C3" modified="2020-04-22" version="1">MPSFFAPGLQGLPPTPPHMISSGRMDTEPFYVVGHSAFPPRYSQNGCEFIEQYSQSTCYSKPPMNMHQSMRTGRDMAASHSMMNQSMYGPMPAGNVLPPIRGNVQLPPMDSAIPPQYRRQDAMVQPEQQQPRKEEKATGGVAARLDYEMDQMSDFVAEMAQGMYALYNTKIHLADIDFARSVYPGTSVPPQFRKYVFQILSSTRLPSSTILLGLYYLASRMRMLSSSKVFMSGNGQVYRMLTVALLLGSKFLDDNTFQNKSWAEVSNIPVSELNKLELEWLFAFEWKIHNRIYDDQDGFASWRSHWDTWRAKTARAHDSRQNLAPIDTNVSRGSRMSKPLMSPEGPIPPQYQRSSQYETSWLNPAASEYSPPSAPHSGPNTPDYYAVGPWAYTNPPPPYSRTWVPPQPQYMPRSQPPSYHHTPSYALPFAQSVWTGHGSSCGCLYCTKHVEHYMCAGAFGSMQPILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDE4</accession>
    <name>A0A5N6TDE4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742575">
        <property type="protein sequence ID" value="KAE8144307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDE4"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="80" mass="9030" checksum="83A0DDBA01A43542" modified="2020-04-22" version="1">MSGLCVDPKMMDDCFMGPACLFEQIIIIPGQNVHTCPSFFSFLFFPDFFIPLLFSIIAWETAVSPHPLVTSTSPFFLTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDH9</accession>
    <name>A0A5N6TDH9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_95460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742526">
        <property type="protein sequence ID" value="KAE8144433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDH9"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8144433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="227" mass="24836" checksum="174D93AE4D88FAA0" modified="2020-04-22" version="1">MTLNLDQPTALVLIDNQAAFTHPTHWGTSRSNPLYEHNIQSLIQAFRLASKKQSEGFPIKEIIHIFHSSTTPASPLHPNDPENGTRPLDFARPATDRSEVVMWKCVNSSFIGTDLEAHLRSRGIRQVLFAGLTTDHCVSTTVRMAANLGVVDRYLDGPLTLNPDDGIHNQTSVDRGRIILVADATATWAKGGFDAETVHAVSVASLEGEFADIMKTEDVVKALTQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDU9</accession>
    <name>A0A5N6TDU9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_145508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742489">
        <property type="protein sequence ID" value="KAE8144545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDU9"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000035">
        <property type="entry name" value="DsDNA-dependent ATPase (Rad54b)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="300"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="623"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
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        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
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        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="949" mass="105650" checksum="DEB7534F70CEA452" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDV7</accession>
    <name>A0A5N6TDV7_ASPAV</name>
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        <submittedName>
            <fullName evidence="12">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_91212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="439" mass="49122" checksum="1574B19134E463A9" modified="2020-04-22" version="1">METAEPVSYEFPGHAIGALAPRRMMNSSVGHNFPFYANPTASFPLPFHQAPSTAYGFNNGISQHQSSQHHPPSYPQFYMTGQQSLNPPMRLSSEPPPIQSIPDIRPAKNAVNRVTRGPLIKADPGLSTQQIHSTNRQAGSNKGLSASEIEFTTEVDILMKAIQSRAVTQPSTLQSLPPLQQLTHGGNNSYTPAYSIHSTTNPRCTMMVEEPQSRSGKKRKYVCTLPHCGKSFAQKTHLDIHTRAHTGDKPFICKEPSCGQRFSQLGNLKTHQRRHTGEKPFSCDICQKRFAQRGNVRAHKITHQHAKPFTCLLDDCGKQFTQLGNLKSHQNKFHATALRDLTLKFSQVTTGELMSPQDRKLWEYFATLYKNSNKGIKGRGKDRRISPTSKSESSRRHQNLSNNEGKTRRSSYEDSSIYTGGSSSDDEDADAYYINRQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDZ0</accession>
    <name>A0A5N6TDZ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_90776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742482">
        <property type="protein sequence ID" value="KAE8144584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDZ0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="517" mass="58312" checksum="95CB2364897F6917" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE04</accession>
    <name>A0A5N6TE04_ASPAV</name>
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        <recommendedName>
            <fullName evidence="5">Mating alpha-pheromone PpgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_166466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025010201" description="Mating alpha-pheromone PpgA" evidence="2">
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            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11524" checksum="E8D4435481C9F81A" modified="2020-04-22" version="1">MKLISVVLTALAATTVQAAALQKWCHGPGQGCYMFKRAADASEEVRRSAEALAEAMPDADASPEAWSKWCHGPGQGCYKVKRAAEAVDEVRRSADALAEAMAALEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEF0</accession>
    <name>A0A5N6TEF0_ASPAV</name>
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        <recommendedName>
            <fullName evidence="6">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_93075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742510">
        <property type="protein sequence ID" value="KAE8144471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEF0"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="6">
        <location>
            <begin position="55"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="389" mass="42738" checksum="28E951FA787AF7AA" modified="2020-04-22" version="1">MAALIARCHHRLPILIGLSICSLIVLLTLSHSPPQKILTDKRGWQTIQNETLGFQKILCINLPSRTDKRDAITLGSSLTQFHVDWVDGISGDSVSEKAYPPHLNDPGRPALLKGEIGSWRAHMNAMQKMLADDLTTALILEDDVDWDITLKTQLQEFALGNHALQKHHHSSSPYGDWDLLWLGHCGVKCKPGKPFYKFHDRTALPPSLLPRYWQGPAVTKGLDTNDTRIVCPITDSVCSYAYAVTHSAAQKILAAMSVSPQDDAMPSGEKTVFDIVLGRLCKTGYLKCISSYPSLIGTWKPGGDKAKHSDIQTLKENTPEESESESESESEPEAEAHSLGVMYSTMSNIQSLLANPQESIHSAIDDVSPPIHDIKNININLAKGEIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEF5</accession>
    <name>A0A5N6TEF5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_166193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742449">
        <property type="protein sequence ID" value="KAE8144712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEF5"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="133" mass="15269" checksum="2FB0881520EF92C0" modified="2020-04-22" version="1">MADAPVTLRTRKFIRNPLLARKQMVVDVLHPNRANVSKDELRSKLADLYKSTKDQVSVFGFRTQYGGGKSTGFALVYDSHEALKKFEPHYRLVRIGAATKIERASRQQRKQRKNRSKKFRGIAKVKGPKKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEI0</accession>
    <name>A0A5N6TEI0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Folliculin-interacting protein N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_166085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742437">
        <property type="protein sequence ID" value="KAE8144778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEI0"/>
    <dbReference type="OrthoDB" id="5428015at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8144778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1199" mass="131430" checksum="746AEC93F7CC55C0" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEP9</accession>
    <name>A0A5N6TEP9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDV25DRAFT_134311</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="ML742425">
        <property type="protein sequence ID" value="KAE8144853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEP9"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000018">
        <property type="entry name" value="Type II DNA topoisomerase VI subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="196"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAE8144853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="384" mass="42599" checksum="53846A2ED06A850B" modified="2020-04-22" version="1">MQRYSEAEGSPTLPHTPGIIQKYIEETLATVLEELSTSDGRPSISLRRRSKKPTLLINPMNGALEGNGPESRLIYSWPGKSAYEAWKFTVIFRVLAAIAENLHIGLVVSRRDIYYSDPNLFGTQKVVDDIVDDVAYTVGLDRSALNVEAAAKGLVVGSYQLKTSSGHVIDTQTSAIDTLVPSLQDIDEITISDSNWVLVVEKEAVYRRLVRLGYYTKALAGKGILITGKGYPDLSTRAFLRKLNESGSRSNKNLPFYALVDSDPDGMAIMSTYKYGSMAHTSENGRLNIPCLQWLGVRTSEVVAGALHNDNEDEASMSLTARDRKKIVAMLCNSPVWAVEGPEPEWRAELLLMLMLNLKAEIEILYDRKDGLERWIDQKMAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF26</accession>
    <name>A0A5N6TF26_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_79745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742406">
        <property type="protein sequence ID" value="KAE8144975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF26"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="126" mass="14566" checksum="1CD3991B4D6D50ED" modified="2020-04-22" version="1">MDERRATGGFGSCVTWFYFLSFVLPFYFYFYFIFLYWVGPCVEIGFYYLVFEVGFGAVNGRVYLGYTWLLVGVCGFVLGFGCSMSMSMSDIVEDWISCGVNFGQVYRIFIISSYTCQVDTPITWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFC2</accession>
    <name>A0A5N6TFC2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interferon-related developmental regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_78211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742392">
        <property type="protein sequence ID" value="KAE8145063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFC2"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="475" mass="53335" checksum="95B44B7C1F8A4669" modified="2020-04-22" version="1">MPDLRRQVLESGKTISRKAASREGSRRTSRTNSAQNSHQSSRNASRPPSDEEDIGNLSDDTALSIGSLDDLTDNPDLDNDNWTQELSDVIQDILDRKRSSVLSREECYAAFCRLLKCHYAEEHIRNRVSDLMGAFCRSVKFESSVRETTLALRALELLVITAFDNVIYENVEPILTRSIRDSTSNIVKAAAIRCLSACTIFGGAGEDGMLDQMTFFLDIAASDGQSINAADDSNSVTAALQEWGVLAVEIEDLESESEDAIQIFMDQLDSSEASVQIAAGENIALLYEKSYTPQEDDEDEEDIGDDMDDQPSSDRQGPKLVKRYDAYHNTHELEQQLQSLATVHSKRISKREKKSLHSNFVSILTTVENPRRGPMYNTAIDQETNRHYGNKLTVKVGRQGLMNIDRWWKWIRLNSLRRILQGGFSVHYFQGNRAVLDSLPVMVRQSTSSDKGAAKRAAKARNSHRWAVHDHSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFT1</accession>
    <name>A0A5N6TFT1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_165669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="ML742408">
        <property type="protein sequence ID" value="KAE8144961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFT1"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="879" mass="99757" checksum="6A383A1FB63DD027" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TG74</accession>
    <name>A0A5N6TG74_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_144966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742386">
        <property type="protein sequence ID" value="KAE8145101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TG74"/>
    <dbReference type="OrthoDB" id="3000060at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8145101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="537" mass="60725" checksum="5B04AF123977A02A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGF4</accession>
    <name>A0A5N6TGF4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ML742349">
        <property type="protein sequence ID" value="KAE8145406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGF4"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025074243" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="518" mass="56317" checksum="1751376D10AFFFBB" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGQ0</accession>
    <name>A0A5N6TGQ0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_164499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742338">
        <property type="protein sequence ID" value="KAE8145512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGQ0"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="546" mass="61225" checksum="6294237E0C27FE1C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH25</accession>
    <name>A0A5N6TH25_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_164211</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="ML742326">
        <property type="protein sequence ID" value="KAE8145632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH25"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="297"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAE8145632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="555" mass="60295" checksum="E4E9864986B4F375" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TH97</accession>
    <name>A0A5N6TH97_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BDV25DRAFT_164086</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="ML742320">
        <property type="protein sequence ID" value="KAE8145706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TH97"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8145706.1"/>
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            <dbReference type="Proteomes" id="UP000325780"/>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
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                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
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                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IBT 18842</strain>
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        <source>
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</entry>
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        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
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                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
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                <person name="Chovatia M."/>
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                <person name="Daum C."/>
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                <person name="He G."/>
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                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
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            <strain evidence="13 14">IBT 18842</strain>
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        <text evidence="10 11">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Atg22"/>
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        <property type="entry name" value="Atg22-like"/>
    </dbReference>
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        <property type="entry name" value="ATG22/LtaA_families"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8146253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="594" mass="65255" checksum="88D746185ACDC33D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJC4</accession>
    <name>A0A5N6TJC4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_162652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742268">
        <property type="protein sequence ID" value="KAE8146360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJC4"/>
    <dbReference type="OrthoDB" id="4344093at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8146360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="338" mass="36323" checksum="A16DCAC0961FEF78" modified="2020-04-22" version="1">MTNPYTSTPAPPILAHALLNKDKDKTTPTQNPTWDLKPDIQNNTIFRPGTVTGLSTFKNPNNTDFLAQFSRTLLTSQLHNTNHTSNRPTKTKIYIIHPAHTDIFSPQNLLNALLFPPHRAQSQKLGRDEAVKYLEGVELFPVFDFGGVVSAVHRIREILSSPFTCATTAAATATSGATATATATATATSSDLPTSGSKGPSGESEGGSNGESSSVLVVAGLDTLAESVVRSSSSVRGTAVLNETLRTLTALSRDLRGLCVVLVNLVPVGSVHGFAHGEGERGSAFQRGMLFPSLLMRTLDGGLDVHLLCSVWKFERVVEVIKDRDGGWSGRWCVWPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJJ4</accession>
    <name>A0A5N6TJJ4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_143622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742257">
        <property type="protein sequence ID" value="KAE8146523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJJ4"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF29">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8146523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="260" mass="28832" checksum="B001D0222E5C8D89" modified="2020-04-22" version="1">MKTITIIGATGNQGLSVAQTFLSQNWTVRCLTRNPSSPTAQSLAQQGANVIKSGPERPRLPEDRDGCRVYADAGAAEVMEYIEAERGELAAKTSYIMLGAYATNPLFMPRWNGEVRRYQFMVPVKRGQMMPVIAARESTGAFVAALVGEEPRTRLLAYDAYLSMGEIVDIWSRAAGVEAELVEVDCAELNRRFGIPWEVLDGPAFIEEFGYTGGVEGIVHPSDLRGVVRTESFEDWLRKRDWEEVLKEGREELESVVHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJQ4</accession>
    <name>A0A5N6TJQ4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5-like heme/steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_162273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742256">
        <property type="protein sequence ID" value="KAE8146545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJQ4"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8146545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="169" mass="18621" checksum="6BBBD868BBD1A9D4" modified="2020-04-22" version="1">MSTAETGAVPPPEVMTIASPINLILLSLFIILIYTQFRPKAPVTLPKSPAPIVFRTFTPTTLLPFNGTEDKPVYLAVRGRVFDVSPGRNFYGPGGPYENFAGRDASRGLACQSFDEEMLTKDLKGPLDELKDLDGEQLENLQSWEERFSEKYLVVGKLVAESDPEAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TJT9</accession>
    <name>A0A5N6TJT9_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_143798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742269">
        <property type="protein sequence ID" value="KAE8146351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TJT9"/>
    <dbReference type="OrthoDB" id="3436553at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8146351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="131" mass="14606" checksum="49D742AB2403BE7B" modified="2020-04-22" version="1">MVSGVQEDDIPKNIPPYTPMSSLGHELGILFGFLAACFIVMGLYVMLWRSMERREALREKVRREQFAARLHSSRGAGPEKPHEVRRAELPGHTTSGFGELASNITMSAGSGARRNRANGWVELDILETPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLN5</accession>
    <name>A0A5N6TLN5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_160939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742221">
        <property type="protein sequence ID" value="KAE8147190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLN5"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="89"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8147190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="549" mass="61328" checksum="D5829F10D8EEB571" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TLY3</accession>
    <name>A0A5N6TLY3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_160576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742212">
        <property type="protein sequence ID" value="KAE8147338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TLY3"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8147338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="253" mass="29390" checksum="0251FB62E6207DAA" modified="2020-04-22" version="1">MDTDKRPERKARRIKLAAIRAKVECLGYGHLSAADLSSSDIHFGPMTLEKDHLPQYFEIYKGDIQMPRDGYVSNSWPRFKPDPWENARNLQFFLDKFVSHPVLPQNDRYPIGPRYRDYGDFPNFGLLLESHAPRWQVQTAWDMPDHRPHMKCMVIHATEGDERLLRGELLTIIDIIRGRLSHKATRASVNAPILLFSFMGSCARMLEANMDSEGLVVRATRLYDFKEEEDVDFSLSRFFARWWMGHPADMSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TM15</accession>
    <name>A0A5N6TM15_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDV25DRAFT_169123</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="ML742210">
        <property type="protein sequence ID" value="KAE8147386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TM15"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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        <property type="entry name" value="6PGD_dom2"/>
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    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
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    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="21">
        <location>
            <begin position="101"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAE8147386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="773" mass="84510" checksum="3D1552B2491C8131" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TMF3</accession>
    <name>A0A5N6TMF3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_142670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8147497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF7730"/>
    </dbReference>
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        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="257" mass="30072" checksum="4746B9C2EB3EABE3" modified="2020-04-22" version="1">MRNKLIICEDKIRHKAIPAILKVFRPKPVLSEPQYKRTSLLELPSEVRLLIYLFIFETSCDHILVKVDRNKRVSRSQIDEDGQDIKPPPGLSYSRTPSVPLSASLLQTNQKIYHEALPILYARVIFSASSNPTSLMYFTDRMSEFARNNIRQIQLYPVPLLSECFIRERDLLSWNVICAAVAELPGLRRLIISYPRPESLEQSTVEFHRSHYAKWLKLVQAEKSLVFDEFEEGSGDMERYRERFRKIMEYTDDMSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TN07</accession>
    <name>A0A5N6TN07_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_159680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742192">
        <property type="protein sequence ID" value="KAE8147752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TN07"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8147752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="93" mass="10992" checksum="5146A37896762C36" modified="2020-04-22" version="1">MGAIPEADPDEPMETKPFKFVTAGYDARFPQMNQTKHCWQNYVDYHKCATAKGEDFRPCRQFYHAFRSLCPKAWTDRWDTQREAGNFPARLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TNM6</accession>
    <name>A0A5N6TNM6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_159356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742185">
        <property type="protein sequence ID" value="KAE8147915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TNM6"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024791990" evidence="1">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8147915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="459" mass="49690" checksum="0E8EAE2A33FAE40C" modified="2020-04-22" version="1">MRVILRLLPLLAAGGFLPTWAADETTSTTSATTKGLLTLDGTIHSKISDAATPTGHYQTYTSTVTLGNHGSIIGSRTVTGTETMMTASNSSSETKTKTSHSLTVLQGSQTISGGNHTANATRTATASATESPVVNTQPCNGYAEFCARNYSNITMVAAHNSPFVKPGSVAANQALLVESQLNDGVRMLQFQTHRVNDTMYLCHSSCEMLNVGTLESYLTTVARWMRANPYDVITILMGNSDYVDPGNFTGPIQNSGLMDMVYTPSKIPMALDDWPTLSTLILSGKRAVMFLDYQANQTAYPWLMDEFSQLWETPFSPTDRDFPCDVQRPPDLAPNDAKNRMYMANHNLNLQVNMLNLDLLIPNTAELNVTNAVSGYGSLGVMARNCTKQWDRPPNFLLVDYYNYGPTNGSVFEVAADMNNVTYNGKCCGIASAAVGLTPQSVLATVLVIGGLQILTSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TPT5</accession>
    <name>A0A5N6TPT5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_168500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742163">
        <property type="protein sequence ID" value="KAE8148368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TPT5"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8148368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="147" mass="16552" checksum="736CF4F0FBDDBD77" modified="2020-04-22" version="1">MSSPPPTPDQQSQRTAEAKAAFTASLRSAATNYDSQLRDRARNIHDNATVLDKQEADVRRATEQLAKQNDQLAKVADQARDGLKEIGDVQNWAELIERDLLIVEETVRLAEEREECHDGHEVQVDGDGNNLKDNGKGKKGQKGWFWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ57</accession>
    <name>A0A5N6TQ57_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_16963</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="ML742158">
        <property type="protein sequence ID" value="KAE8148492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ57"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="797"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="396"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8148492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1126" mass="122098" checksum="3440C07BA757C1D6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ79</accession>
    <name>A0A5N6TQ79_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="11">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDV25DRAFT_158140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ML742157">
        <property type="protein sequence ID" value="KAE8148512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ79"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="13">
        <location>
            <begin position="278"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="10">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAE8148512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="713" mass="82086" checksum="304FB455CCE15975" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQ99</accession>
    <name>A0A5N6TQ99_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_168365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742156">
        <property type="protein sequence ID" value="KAE8148532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQ99"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8148532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="731" mass="81899" checksum="2279ECC650B1882C" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQL0</accession>
    <name>A0A5N6TQL0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_16265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742155">
        <property type="protein sequence ID" value="KAE8148577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQL0"/>
    <dbReference type="OrthoDB" id="4510881at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024793113" evidence="2">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8148577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="312" mass="31208" checksum="52702434E1EADFAB" modified="2020-04-22" version="1">MQFTTKISVALLAALAAGTEASHARNHKLFHPRNVNSTVSTSSVFIYPTPQLPSSSSPVVGSSSTVRSSAPVSSSAAAGSSTTTRVPTIPLSTGVAGSSAATTKTQLATEDVTLTYTLGTGTSTSVVTTTIHRTATETQTVYVPTTGAAAPSISAPAVGNKEQTTTRHSTSTETITMIEVPSSSAAAGASGSAGGQLCSAPATVTVTATVTETVAPSATPSGSYSKPGDQEKVPGNADTGADDNEDQGEGQGEGEGNEDTSSSLPPAPLPTHSGRPPFGNGTLPIPTSGAAKPTGFKTTGKPAFPTNFRRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TQV4</accession>
    <name>A0A5N6TQV4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_157798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742150">
        <property type="protein sequence ID" value="KAE8148680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TQV4"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8148680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="489" mass="55438" checksum="6C88A0955F738E76" modified="2020-04-22" version="1">MSFPSRGCQTCRDRRIKCDKNLPICLRCINSRRTCYGRRDQQVWHTENAYASRQTKRPRGPRPAKVDLTVSPIPTDLKSCALAYYMHNYSETPLGVPDFVKEVTGGCFPILPSAPWCSIIDLAISSVALATFSRAKRYPKAAIEATSTYAQLLQISQAELHCLNSRNLDTCLLAVFFMGRYEDSIYCPGSKIPLQLTLQSFSHHDGAMAILKVWIDRLRHNGPATNVIKHTRRGLIRSVLMRHAALPEWIQDGALFGEDGFELVYDRILVRVVNLRHRLVSLNMMVLPQPGIVGNTVEINEFNKDAQVLDEDLEHCVAQVPRPLNSLRRHRISELISWPTKDFYSPVVYSYSSLAYAAACCQYYATRMLVKSTRLRILALSSVSDMAQEQQLSFEMRYIGDDLAASTPFCLRRFGLTTQSHRNPINLNTDEYIKPIDARLIIWPLSIASSLDNMDISQKTWFQGQLSRLGKIVGFGVLESAEKDDWLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TR78</accession>
    <name>A0A5N6TR78_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_157375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742144">
        <property type="protein sequence ID" value="KAE8148835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TR78"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
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        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
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    </dbReference>
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        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="199"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="290"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8148835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="682" mass="77255" checksum="54FCAE77285F5CFE" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS02</accession>
    <name>A0A5N6TS02_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_6526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ML742133">
        <property type="protein sequence ID" value="KAE8149133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS02"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAH (Asp-Glu-Ala-His) box polypeptide 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="152"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8149133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="622" mass="70645" checksum="E28E4F76E688F79B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS07</accession>
    <name>A0A5N6TS07_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_156969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742135">
        <property type="protein sequence ID" value="KAE8149084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS07"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069855" evidence="2">
        <location>
            <begin position="17"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="4">
        <location>
            <begin position="148"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="3">
        <location>
            <begin position="342"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="740" mass="80770" checksum="2E6C67F6A3ED2071" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TS75</accession>
    <name>A0A5N6TS75_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAFII55 protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_156774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TS75"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="133"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8149206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="480" mass="53466" checksum="97B73B6D41D8B646" modified="2020-04-22" version="1">MSEGRPSLKLTFGKKKAPEAPPPPSPAPPPPSETPQRKLTLKIARKPTTEAEPEKPKKKKPSKKRPADEPAPSEPAPAPAPQQQPGPKRLKLNPSKKPGLQSIRIKNKGAVPTRPVGVGYDSEASDTEIDPSIEEQFILRMLPGPECEYLHQMIQERKLHESQISFRPLTREGRRAIFKVKDKQFAATLVDMPCIIEGMKSWDRRGWYKSGDICQMLLILGPVSSDKEALEYELPSGIGRSDDKTLQYPHGLVPPLRWVRKRRFRERVSTRTIEQVEKAVEDLIAQDEAAVGHPRYELVDSAALNRAEGLVQSEDFDDYEYDDEQDAEGEVDEGMDGLFDELEAEMEAALAGDAPDHNTAPEGVNTGVSMDSGVYQAGTPTATKPSTPAAESSGDESEESDGDRGDPEDDLDDEQLEQQRQMQQQREEIVELEALIRAETAKWEKMQNQILKNKLAKRIQELQRDLSLKKVSIGEGDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSM2</accession>
    <name>A0A5N6TSM2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nucleolar ribonucleo protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_156440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742125">
        <property type="protein sequence ID" value="KAE8149355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSM2"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000518">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="942" mass="104655" checksum="DB51DB6973E98D9A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TSY2</accession>
    <name>A0A5N6TSY2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_156416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742124">
        <property type="protein sequence ID" value="KAE8149407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TSY2"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="173" mass="18597" checksum="D4F9C374978C7702" modified="2020-04-22" version="1">MSAVTRSVRPFASRVLSQKLPLAGVRRVSPAMGFPRGSVRSFSQSPFMEVKKYTESHEWIELADDGKTAKIGITEYAAKSLGDVVFVELPEADLEVSAGEPVGAVESVKSASDVLSPVAGKVVKGNEILDDKAKFINEQPEGDAWIAEIEVKDAAELDGLLDAAAYKETIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT13</accession>
    <name>A0A5N6TT13_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_141030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742131">
        <property type="protein sequence ID" value="KAE8149201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT13"/>
    <dbReference type="OrthoDB" id="2913095at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="303" mass="35005" checksum="B57ABF98720A5245" modified="2020-04-22" version="1">MLPPHPKTIEMIDDGKEVAAEDHVDILNRLGTLHYDEKNFELELQYNKAAFDKNTNDINTRYALFKTYHRHQKAEEARNILEEASKYPIDGTATQLKRLIQKAAEDKERPLYILYGMATLCASESGTLNSMLKDTDTAIEEARMARSYRTLAPFLLHKGVTIRYFCVNEPDSHGSAFEIWKECKLEIEKNIHEADDKTFYLEQVNRQLSLYYFEQLETGEMRTEEHIAELEQITQSHTGLSPAKMYLAAYFRSHNRPDKARDLLKPHMSLAFDLLSDEATADDAEAYSILHDILITYGEIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT85</accession>
    <name>A0A5N6TT85_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_140686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT85"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8149573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="308" mass="34123" checksum="0A4CC6A6BE303D0B" modified="2020-04-22" version="1">MFYYRPLSTPKDLPPSTEPFYPNIYLRSQLCTKPQWPPSSTSVEDKVAIVTGSNTGLGLESSRQLLSYNLSHLIMAVRSIAKGEAAAAELRREYPLATIEVWQLDMTSYESIQKFVQRTETLPRLDIVILNAALGNLTFNIVKSTGHEEAMQVNYLSTVFLSILLLPVLKRKSPTGPGRLTIVSSGLALTVGIPTKTSSPLMTTFDNPKTYKWDTQYSMSKLLGHMFLYKLVDFVSADDVIVNLVDPGFTKGTELQRQASGLLSVVFSLAKLATARTVRDGACTYLDATVVKGKESHGCFLMEWKIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT94</accession>
    <name>A0A5N6TT94_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylxylan esterase</fullName>
            <ecNumber evidence="5">3.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_3804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Deacetylation of xylans and xylo-oligosaccharides.</text>
            <dbReference type="EC" id="3.1.1.72"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate esterase 1 (CE1) family. AxeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.72" evidence="5"/>
    <dbReference type="EMBL" id="ML742126">
        <property type="protein sequence ID" value="KAE8149349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT94"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039620527" description="acetylxylan esterase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8149349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="263" mass="27859" checksum="BE887690CF71BD91" modified="2020-04-22" version="1">MLFSSFASALLCGVSAVLAQRATLTQVTDFGSNPADIRMYLYVPDAVAASPGVVVSLHGASGNAQQQFKSTPYAKLAEQYGFVAIYPESPQGAWDATSAESRTHEGGGASQSIANMVKYVLDTYNAEASKVFVSGISSGGTMTNTLAAAYPDIFKGAVIYSAGSSDNIRDMYPGYTGSYPEIQLYLGSEDTVIGSDAFNSTLAAWAAVLGYDDTPDRVLGDTPRSGWTKYVLGSKLEGIWAQGVGHPVFTQGAEDMKWWGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TT96</accession>
    <name>A0A5N6TT96_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_155995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742118">
        <property type="protein sequence ID" value="KAE8149586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TT96"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8149586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="268" mass="29461" checksum="C8138B4765FDBF6A" modified="2020-04-22" version="1">MSGYDRALSVFSPDGHVFQVEYAMEAVKRGTCAVGVKGKDVVVIGCEKRSALKLQDTRITPSKIAVLDNHAVLAFAGLNADARILIDKARLEAQSHRLTVEDPVSIEYITKYIASVQQRYTQSGGVRPFGISTLVVGFDPNDKVPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNHQDEMDREQTIQLTIKSLLEVVQTGAKNIEVAIMSPGQTIEMLPEDQIEAYVKSIETEKQEEAAKKKTRTGTTTAAILTRGGGEGSESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTC5</accession>
    <name>A0A5N6TTC5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_130257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742119">
        <property type="protein sequence ID" value="KAE8149550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTC5"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="67"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8149550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="332" mass="37281" checksum="DEA534279308A63F" modified="2020-04-22" version="1">MLRVDVLKSIVSLHPWESTYSRASRYFLSEKMRRVWTFATMYLGMSPYAAPSTYSLLQYIETVDGICPVESILLSDTGSATGVRLASGTELHADTVVINADLVYAYNELLPPSPQSRKLKQRPASCSSISFFWGFSESLPYLQTHNVFLADEYRESFDAIFAHHQIPNDPSFYVNVPSRIDSSAAPCDKETVVVLVPVGHLTPTQTEEEWNDLVTRTRDKVLNIIESRTGLHSLRSKIVHEIVHTPVTWEKRFNLDRGAILGLSHSFFNVLCFRPQMKHPRIGGLYFVGASTHPGTGVPVCLAGSKLVTRLIVQDWNSTGSRMFLYLHLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTJ8</accession>
    <name>A0A5N6TTJ8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium:solute symporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_124203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742116">
        <property type="protein sequence ID" value="KAE8149683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTJ8"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8149683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="675" mass="72715" checksum="50DF071E49756345" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TTK5</accession>
    <name>A0A5N6TTK5_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1295 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_130165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742115">
        <property type="protein sequence ID" value="KAE8149705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TTK5"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8149705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38854" checksum="284FA7CE163818B8" modified="2020-04-22" version="1">MDIYGSKKPLVDIDHSINQMAGQKSGYLNTGDVGIFKSTILPSFTLHTGLSVASFVAAKSTDKGEVKDWCWPSSQVINAWWSAVGRQVVCDNVSFSTAWNAIPWTEKTLLSCVTIWGTRLFYRIATRTIKRGKDDPRYDQMKQQDPSFWKSAFFKQFLPEAVFLTFITLPFTLPFRLSQSSLNINTETVGVFRALGVGLFSAGFAMEALADTQLELHRQERTDLCRHGVWSIVRHPNYLGDALVHISFVLLNAANSFNPAVLLGPVANYLYLRVVGGDKQNEASQEARYKEQDPHKYKQLQAWRREKNSFWPSPSELVNPWTWAVIGSGVVGVVLEEAVRGWILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TU11</accession>
    <name>A0A5N6TU11_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_155473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742110">
        <property type="protein sequence ID" value="KAE8149856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TU11"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8149856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="276" mass="29618" checksum="291BED2464790AA2" modified="2020-04-22" version="1" fragment="single">MPVAPSSDAPTPATISVVGTASQYPSNQHEPEFLPQLSKRHYAHSSAYVSIRHSTLSLNVFSLEKTLEIHMRTKIEKRYSVLPDTHPLWHQDKVPTVTECIAISEQYGLPLAKAAAKEAIAEWGGDIQGITHVIAVTCSGGSSPRFDSALCKHLGMSQHARRILIDGMTCAGSVAALRTAYELLLGATCVGQPGRALVIACETMSIYNRAWLDHIVTQQTPNLAPTLFGDCSSAVVLSNMIGVKDTERPPIWQIIGAQPTLTTVSGVIGDNIVPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TUP5</accession>
    <name>A0A5N6TUP5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoenolpyruvate phosphomutase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_118880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742106">
        <property type="protein sequence ID" value="KAE8150004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TUP5"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8150004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="276" mass="28819" checksum="1D7BDFF51C7D76A6" modified="2020-04-22" version="1">MALRTAQNNLAISFRNLHTPGQPLLLTNIYDAATASIIASHPSTKAIATASYAIAASQGVPDSSLTLPLNLASVRSISAALKCTKDASGESIANKLPLTVDIQDGYADIAQTITEIINLGAVGCNIEDLDSATGMLRPLPEAVHRIKKAMQTARDLGVPDFVINARTDVLCENPGGKPGSIDEAIERGRAFLEAGACTVFVWGGAGGRGVSRGEVAELVAGFSGKLNVKLVLRDGFLTVTELKELGVARISVGPELYRAAMGAFKEKADALLASYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TV41</accession>
    <name>A0A5N6TV41_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_154853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742100">
        <property type="protein sequence ID" value="KAE8150233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TV41"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="348" mass="39134" checksum="CB5661BD240ECC11" modified="2020-04-22" version="1">MSAGQSYLQKLRKPQLAEWAAFSDLHDYEEYNKPELIVALDKHLQANQSIFSNDPRLAEYYKRLTQSPRKGSPLKREPQVELTPLRDAPRSVRRRQTKPKEEVVEEEQIKLAEDSEASSPVIPALFQTPARSPQTSSIGHVDDIIAPSPAALTNAIDRQTTRMWKGLADLWFDSKLPQASNSLRSSLSSVQAVHYLLLLLEGFHVAREALPLRYVTTVRVWLSFLSAVEIHVPDVFALLEGSFWAPFSLWVLTSVALPLTAAYFFNIRLNVKGNARSRQDGQFDPLSYTIAKGLISYLVYGRGFNFWNIYDPITLERVNSAVPGQVSGLFLGCSIGAIGSIYEEILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TVN6</accession>
    <name>A0A5N6TVN6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742096">
        <property type="protein sequence ID" value="KAE8150357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TVN6"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56549" checksum="7D872BD3970F0E68" modified="2020-04-22" version="1">MDGGMQLQSYDGIVSDISDSDSPLLPWDEIYQKVLLTPRLRPSLVDSSFATSQLSSLLSASSYPIPETIPEAFYPQRPTEPWSYTPQLQTSSNHLLPSPPSDRDHVMDFQRQIPSRASQTQTPTTQRPPKRQHDSTPAPATTKKRGRPRKTMDTQLGEDPEERRRMQIRLAQRAYRSRKEANITSLKGRISQLESTLEKMSSAVVSFSDDLVLSGALTSHPDIASRLRDTVQTCLTLAKEANKDSDHDLPDISSHSEESISSPPPGPENKSEGRSISAPTTTLGHQFDSGEPVESVQSISPPLSAPLEVSVMEIPTFIERLHMACVYQGYLVLTSPSVPMSRIERPFRFLLTLMDRVRLTAAFEALLHAKLTQKRLEACYAGVPFFKLGGAGTHYPRSTDMIQEDENPLQRYQQWTTIHDPLSRFSPDIRREMGGDWFDMQDLAGYLKEKNVVLLSSPPKPDQSSRLTVNATRLIQALIGRGICLGRSPGFSRYDVDKALRSSSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TW41</accession>
    <name>A0A5N6TW41_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L21e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_154341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742093">
        <property type="protein sequence ID" value="KAE8150494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TW41"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000002">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8150494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="158" mass="18128" checksum="A3E1853932D68D55" modified="2020-04-22" version="1">MGHSHGLRSGTRYAFSRNFKEHGQIHLSTYLKTYRVGDIVDIKVNGAVQKGMPYKVYNGKTGVVYNVTKSSVGVLLYKVVRNRYLEKRVNVRIEHVKHSRSREDFIKRVKENAQKKRQAKEQGVHLHLKRQPVGPREAHVVEGVSAETITPIPYDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TWT2</accession>
    <name>A0A5N6TWT2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_153801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742086">
        <property type="protein sequence ID" value="KAE8150750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TWT2"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000512">
        <property type="entry name" value="RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8150750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="714" mass="79661" checksum="CCBBE8517703ED8D" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TX05</accession>
    <name>A0A5N6TX05_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_139423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742084">
        <property type="protein sequence ID" value="KAE8150827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TX05"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8150827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40731" checksum="5A543F472C292397" modified="2020-04-22" version="1">MGSTTVPTWLDKLEEQLNVDVDWMDPAFTKSLPIVPNDMTSNQLWVNEQMNHPDNVELFNNAVKEYKEQGWLAIYTRIACLMCKENIGNIKGRVLLQVLPSNAYDGQKVLEHARMYAREFEKVGISKDRFCIKIPSTGPALSVCPILREEGIATLGTALFSLPQAIAASQAGCLYISPYYNEVRAHDDLSLWPDVDDPATQHTMSARIIQMLETYRRLFETTGKEQPLIKNASFISVKEAMAAGEMGCHSATISPQALTELAKLPYDGSKQPGQGIPKPTHPNHQNSVPTPVRLKEVAKTDPLAAAHWDGQLASTEIDYLDNNGAELERAIKSDPITVIRLKDALELFIGGENKSRAKIEDALKQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXH5</accession>
    <name>A0A5N6TXH5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_101214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742079">
        <property type="protein sequence ID" value="KAE8151088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXH5"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="345" mass="37387" checksum="C4F6AF69FEAE640F" modified="2020-04-22" version="1">MQLGLSESLPALVAKRFTTAKEAGHLLFSQTHLSTIHAGIPYQLRYCPALANKPSGAPNPEKSSSKPKFDPFQDPSPDLLIAQIPRENPTHVLVLNKFPVIPNHFILATKAWKPQTDILEKGDLEATYACVKAWGEEHQAKGTDPQRLFAFFNSGNESGASQPHRHLQFLPVEAMAEGDTGSWRPLIDVVASQPKSSGSEYQTAAEIPFAHFALPIPPNPSAEVLHSIYLSLYKAAVATAQGRSASHSRTTSGEAAISYNLALTDSVMLICPRRSESAQIRVDSATSKDVAEAGVVALNGTVLAGTLMVKAEAEWNELRRHPEGLREILAAIGYPHPDPRELSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXT9</accession>
    <name>A0A5N6TXT9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_139345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742082">
        <property type="protein sequence ID" value="KAE8150909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXT9"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1221" mass="135245" checksum="CA4C6CDF04902E7A" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TXZ6</accession>
    <name>A0A5N6TXZ6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742081">
        <property type="protein sequence ID" value="KAE8150969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TXZ6"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8150969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="507" mass="55253" checksum="AF4B631DC1A792A7" modified="2020-04-22" version="1">MELPYWRVLVDQSVLTKDVINYPYEGSGTENDPYIVEWIPDDPRNPMRISTGLKWAYTITVAFATFGVSLSSSCYAGGIQEIIADFNISEEVATLGVSLFVLGFAVGPLVWAPLSELIGRQIVFFVSYGALAFFCAGAAGSQNPWTLIVLRFFAGSFGSSPLTNAGGVIADIFPAEQRGLATSLFAGAPFLGPTLGPIIGGFLGENAGWRWVQGFLATFTGLIWVIESVLVPETYAPVLLRKRAAKLTSLTGKTHKSKLEIERGKVSLASTFGTALLRPWVLLFAEPIVLLLSVYMAIVYGTLYMLFDAFPIVFQQTRGWSEGVGSLPFLGVMVGMMAAVAANMLDNRRYVAIHRKHNGFAPPEARLPPTMVGGIAIPIGLFWFAWTNTSPVHWIVPIIASAPFGFGMVLVFLNIMTYLIDAYTIYAASVLAANSIIRSCFGAVFPLFTTYMYADLGLHWASCVPAFLALACLPFPFVFYKYGAGIRRRCRYAAEADDFVRKLAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY31</accession>
    <name>A0A5N6TY31_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pheromone-dependent cell cycle arrest protein Far11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_139032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742075">
        <property type="protein sequence ID" value="KAE8151225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY31"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="557"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8151225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="119489" checksum="0CD936B20927B984" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TY37</accession>
    <name>A0A5N6TY37_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_101495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742080">
        <property type="protein sequence ID" value="KAE8151009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TY37"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8151009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="88" mass="10530" checksum="B8449AA1A69490C2" modified="2020-04-22" version="1">MVPYGVTRLYNSYLEIPGRTIRPLPTIVTRFYLLVEHFYFFFCSLLDQVHILFYIRVDRSHHWRPGLGIIMGKEKSWGAFCMHFTRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TYC4</accession>
    <name>A0A5N6TYC4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_95012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="ML742072">
        <property type="protein sequence ID" value="KAE8151383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TYC4"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8151383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="415" mass="44388" checksum="02B9D8FB5F101720" modified="2020-04-22" version="1">MGLRSAKSADRLSIRQPRLLFSRLIVCSTLLLGFSIVLKSRHRLSSFFPHLLTPTHSYSQITNMSYQQERYIAELAVQRATLLTQKVFNEKAKGTVSKDDKSPVTIGDFGAQALIIQAIRKNFPNDEIVAEEEASSLREDKALSAEIWRFAKDIKLEDSESDELLGGPLPSEDAMLDIIAQGNSTGGAKGRIWALDPIDGTKGFLRGGQYAVCLGLMEDGDVKVGAIGCPNLPVNDADTMSASIGVDQNSGAGNGVLFSAIKGAGSISRSLTAGALAESKSISMRPVPDISQAIFCEGVEAAHSAQGDNAAVAQRLGITSPSVRLDSQAKYCSIARGAGDIYLRLPVKKDYQEKIWDHAAGDLLVREAGGQVTDIYGQRLDFSKGRTLAANKGVVAAPKALQDQVIDAVKVVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TZM9</accession>
    <name>A0A5N6TZM9_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_152196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742064">
        <property type="protein sequence ID" value="KAE8151827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TZM9"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8151827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="350" mass="39510" checksum="5653AFCD80187F8F" modified="2020-04-22" version="1">MFWGSHSDDNAEVTHEPLPRQKLPPQLQKLVDRDDGFYDDIYSPYSVDSTNTPYRYAGYANRLRTILLSAHRYVAYTSDIGESFRPVAHPYLVRSAYAISWSYLIGDVAHEGYKAYLRNRRVLAPPCEAYKDAKDLSQEDIAKGMATGNISGPLRAGDSPDTLTPWPTTKIPLIEDYRLIMGKRAVFQSVASMGLPALTIHSIVKYSGRALKNSKSVFFRTWAPIGLGLSVVPFLPYIFDEPVEEAVEWSFRKAVRAFAGEDAVRPLPHIQTPDRDLTSLSHFFLAQEEKDNNVALGADASTLANTSWEEYKEERRQAKEHRKRHLEQNGHKGPWAMLGFGSGDEKRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0E0</accession>
    <name>A0A5N6U0E0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_151768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="ML742060">
        <property type="protein sequence ID" value="KAE8152014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0E0"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="36"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="620"/>
            <end position="886"/>
        </location>
    </feature>
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        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8152014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="902" mass="102375" checksum="C822FB0D3D3019C1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0J7</accession>
    <name>A0A5N6U0J7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_128474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KAE8151879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8151879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="513" mass="54380" checksum="55AE84B8C6F74756" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0K7</accession>
    <name>A0A5N6U0K7_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_151727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742059">
        <property type="protein sequence ID" value="KAE8152098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0K7"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="265" mass="30451" checksum="A594FC4DD9B40E88" modified="2020-04-22" version="1">MIQAERAWNVQPYPCIAKLLFLHFDLSKSPIFDRIVSMLDTDSLLLDLGCALGQDIRRLVYDGAPAESIVGMDIHQEFIDVGYELFRDRHNLKARFIVGDFFKSCPGLEDLAGSIRVINSGYFMHLFTWEGQVDVAKRMISLMARREGDIITGVNFGNQTSGFWEKHLAVTGPMFLHDSASLSAIWRQIGQETQTHWRVWSSVEEDKEFRKLDAGGFRLRWFVELEHCVPANPCEYTMDKMSQKPDILQEHYGDRLMSDAHDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0M4</accession>
    <name>A0A5N6U0M4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDV25DRAFT_151675</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0M4"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAE8152160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="315" mass="34074" checksum="FF30CABD7E9CD1A3" modified="2020-04-22" version="1">MAKGDVNQADKSVFGMPGFVVDFMMGGVSAAVSKTAAAPIERIKLLVQNQDEMLRAGRLDRKYNGIADCFRRTAASEGVVSLWRGNTANVIRYFPTQALNFAFRDTYKSMFSYKKERDGYAKWMMGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGDRQFNGLVDVYKKTLASDGIAGLYRGFGPSVLGIVVYRGLYFGMYDSIKPVVLVGPLEGNFLASFLLGWTVTTGAGIASYPLDTVRRRMMMTSGEAVKYNSSIDAFKQIVAKEGVKSLFKGAGANILRGVAGAGVLSIYDQVQLILFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U0P6</accession>
    <name>A0A5N6U0P6_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_151637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742058">
        <property type="protein sequence ID" value="KAE8152138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U0P6"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000127">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000113">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="574"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="653"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="714"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8152138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="792" mass="88424" checksum="47812C3AE5351F96" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U1W7</accession>
    <name>A0A5N6U1W7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_57351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742049">
        <property type="protein sequence ID" value="KAE8152677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U1W7"/>
    <dbReference type="OrthoDB" id="5354458at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="3">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="2">
        <location>
            <begin position="487"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="792"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="523"/>
            <end position="533"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8152677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="853" mass="93077" checksum="5AF048F39D5E377B" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U2F1</accession>
    <name>A0A5N6U2F1_ASPAV</name>
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        <recommendedName>
            <fullName evidence="4">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="4">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BDV25DRAFT_127979</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="21">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="4"/>
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        <property type="protein sequence ID" value="KAE8152411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005743">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c1"/>
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        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="AAA_lid_TRIP13_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRIP13_N"/>
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        <property type="entry name" value="CYTOCHROMEC1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="16 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="24">
        <location>
            <begin position="517"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAE8152411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="738" mass="82486" checksum="5049698EBADDC5FC" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U307</accession>
    <name>A0A5N6U307_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_137263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742044">
        <property type="protein sequence ID" value="KAE8153023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U307"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF129">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE HXNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8153023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="385" mass="41816" checksum="B6968191630B4C46" modified="2020-04-22" version="1">MGSISTTTAPLFEPLRLGALALEHRIVLAPLTRMRATKEADGVFVPNDLNVEYYSQRATKGGLLLTEATPISRHAAGYPGVPGIFTPSQIAGWKKVTDAVHAKGGFILCQLWHVGRATVPAFIEGRQPLSSSDIPITGKALSGSEYADSPPRAMTVEEIGETVQEYAAAAKRAIEAGFDGVEIHGANGYLLDQFLHDNVNTRTDKYGGSIENRSRIVLDVLKATSQAIGSDRVGIRLSPYNYYQDTRDSNPNANWLTLCQLISGLPAESRPAYVHMVEPRFDEVLDERAKLDSLATDKPSLDVFRPVLKKADVAFLAAGNYNSENAGPKLVGSGADAVVFGRLFIANPDLPRRLLEGLPLNAYDRTTFYGADPPSKGYVDYPFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3H3</accession>
    <name>A0A5N6U3H3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_149818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3H3"/>
    <dbReference type="OrthoDB" id="4367430at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="97" mass="11088" checksum="E79CEE8016D056F0" modified="2020-04-22" version="1">MPRYPTQILRNIEYFSSFSTPQVSALLSRPLLIFCPWKPEARVARPNAATYSTKTSPDGKHVRDCHFEYNWIDGAESLEKYGPGGYHPIMIGDVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3K0</accession>
    <name>A0A5N6U3K0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_150014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742043">
        <property type="protein sequence ID" value="KAE8153142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3K0"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="259"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="356" mass="40017" checksum="35AFADD7F96B1E9A" modified="2020-04-22" version="1">MSTLHSNIAYLRSPSFTPRQSHLCDVIGLYPEEEAFCAGYAPSQGRRCKCRTNAADRRTACNLLGQANDRFRAGIDVDDLLDALAPLVLCRRFHRYQADDLTTIWRRRLRSSQPSPRPAQRAEEDDFVREVYIAGLHQKIDELAADLRRAERERDATPTPPGRRVISREITTNPTLVEATAVPASPPRMVFRSPTTGQGRSASATTTHEQARNDPLTNGSTPSTPSAERSRPTDRASSPSTPTPHIQPSAVRRRIEGECSICTMPLQGPDQSTARDEESRSQNDDNHQTQREGQREQSTERDTNGRSTSEELVWCKAQCGHNYHKACMDEWISQCQQNEDYPRPANCPTCRCAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3N4</accession>
    <name>A0A5N6U3N4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_38592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742042">
        <property type="protein sequence ID" value="KAE8153184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3N4"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="479" mass="53982" checksum="6EB0F7A326485CD1" modified="2020-04-22" version="1">MVTKHLHNLHPHGWETSPDEERFKVSTLDYLTGLCYTHFAVYFRIPELEKPRVATVLKEGLERTLGQIGHLCGTIEKDADGGHSFVKRKDSTVQLVVQWLDTPEDSTTFPSIDDLEESGFAGLALGDFKHWRIEPMTYGEKPEAHPDCSPVVSAFMANFIRGGLVFITHMHHYANDVMGWAGFIHQLAENCRAIWTGTPFPPWDPSCNDVSIVTRPVPPAEQQIDGPLIPQLHPDQKPGQCLLFHLPKSKAAELKRIATPPDGTWISTYDAFAAFIWRTATRLRQPVFQTPLDSPIFWSESVDMRRRMSEPPVHPRIQHNVLWAALSDQMPFPQLTHGDVISDKALWELAAYIRMVTNTQTQANLDTALDAVAYIKDKTNLNIRINSKPPMSIITTDHRAADVATADFGFGRPICHRHLQRGDGVTVGVHVVYPPIFGEDVGLDEGNMFAIMYEKELAPDLVADEEFRQFFEYRGVDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U3R5</accession>
    <name>A0A5N6U3R5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_127340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742041">
        <property type="protein sequence ID" value="KAE8153265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U3R5"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17316">
        <property type="entry name" value="Perilipin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="243"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8153265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="506" mass="57132" checksum="3423F357F5EB1A5F" modified="2020-04-22" version="1">MPHAEPEKMGENAVNGDRIHSHFIDHLTSYPVVSDSITAVKSNRYGAKGFQYADQSYDRLAKPLLPYISKPYNYIAPYVARADSLGDQGLTKFDTTFPIVKKDTKTLKETFYDSACYPMRVVGDAKSHIFDTYGSEYKKCGGDGVVANGKAVVTTSLILTQESIGYLASLLQQKKVQVKDAEPEPESDPEGSESENEHVHENENEPSTQRSRQRRRPNASDSSDDDEPDTYHPTSIDVMVKKMVRLALSSEYARQPIRRTEVSAKVLGEQGVRQFRTVFEAAQKALRERFGMEMTELPGRQKVTIHDRRAAQRVEKPSATNKSWIVTSTLPAAYRKPEILPPTKAPWEGTYTGLYSFVVAVILLNGGSLPEQKLDRYLKRTNADTYTPIDRTDRLIQRLCKDGYIVRLREMDGGEEVIEYMVGPRGKMEVGPQGVAGLVREVYGRQRAIDDAEPTALESEQMKEFELRLARSLGISRPEPREPNENDNAEPERRQTQRREEDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4V7</accession>
    <name>A0A5N6U4V7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_149190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4V7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8153636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="500" mass="55769" checksum="9572FCD19BA4359A" modified="2020-04-22" version="1">MGVLENNGPNDSVAMEAQKAPSESVEEHHPWTVVEENPIIRRIDICLLPLMFVSYLLQYLDKTALSYASILGLLTGTHINTSQYSWASSAFYFGYLVAAYPVSLGFVKFPIGKYLSIMMILWAIVLTCHAAASNFAGLTSLRVLLGVFESAISPGFTIIVSMWYTPSEHALRSCIWFSGNGVAAIFGGVLSYAIGHAHNRLGPWQWLFIIFGVITLIWSMFLFFVLPDSPLNAKFLPSSQRAPAYRRAQQSQQSYQSREWKRDQFIEALIDPKTWLLFVYNFLVSLPNGGITNFSSLVIASFGFDTFNTLLYTIPMSVVALAFLLASALTCNRFHGLRCYWMIVTLGISLVGILLMRQLPTERKWGRLVGVWLVTVFGAGFPLSLSLVSSNFAGFTKKSTVTALLFIGYCVGNIAGPQLFKSEEAPRYNTAFAAILACFCIAIFVVVALRVYMVWENKRRDAKLGRVIEPESKDVDMSGQEKENGGDVSDWQNLSFRYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U4Z0</accession>
    <name>A0A5N6U4Z0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_168626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U4Z0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8153642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="313" mass="34896" checksum="68867D003FB8031A" modified="2020-04-22" version="1">MDTITVGIAGITGKFGRCILARLLRNPGVKIRGYCRQFKNLPIALLHSDNVQIIKGQSDDLQKVRTFVTGCDVVICCYLGAPALMVDGQKVLIDACELEGVPRYIASDYSLDYTKLEYGQIPPKDAMKDILAYLETKKVEGVHVMIGAFMETLLSPFLGMYHASSHTLNYWGAGDEPWEVTTYQNAADFVASVALDRDAVGFHRFIGDSKSIRQIAEAFEEVYGRKPGLNQYGDMKDLYSRLEELRQKDPSNIFSYLGFAYQYYAQTGQTAVLQEPETAGVTVPHVTFEDFFRRHTLESIPSCIGRVGSNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5F1</accession>
    <name>A0A5N6U5F1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_127139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742037">
        <property type="protein sequence ID" value="KAE8153639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5F1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="98"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8153639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="576" mass="61844" checksum="98ECD5267711B873" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U5T3</accession>
    <name>A0A5N6U5T3_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde/histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_136372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742033">
        <property type="protein sequence ID" value="KAE8154003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U5T3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF11">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="214" mass="22781" checksum="12E608E14E510CEC" modified="2020-04-22" version="1">MRVISPDTYTAIITAENGKAKAGAGGEVLFQQASSNGWEEAAGIYGDIVHDSSASSRARVIKEPVGVAAALAARCTVVLKPDGQTPFSSNALAVLSEHAAIPKGVVNIITALDNTPSSVSLCWSNMLNKLGLEMRENTPFIVLDDAELQVAIDSLLASKLKVTGQMCVCANRIYVQTFCIRWIQAFCMGREGSKYGLDDYLTIKTTVTAGIHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U621</accession>
    <name>A0A5N6U621_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742034">
        <property type="protein sequence ID" value="KAE8153869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U621"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000014">
        <property type="entry name" value="SET domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8153869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="497" mass="56807" checksum="A55E5564E2198F92" modified="2020-04-22" version="1">MKRNYLPTETLPSWAKLNGISVDGINFRKLRTEDGIDKGCAIVATEDRSNEQLSGTEEANTEVLLRVPSDMVLSLQMVENHAKSDRYLREVLDAVGDFGRTARGAILIFLILQITYSTPDFANEHHRIGLSNPWTEYVQYMPSSILLPTFYTSEERELLRGTSLKMAVDAKMASLEKEFEHFAESTEEIGWCQKHWWDEETGKLTFHDWKYIDAVYRSRMVDLPRCGHAMVPCIDMANHAPEDTVKALYEEDTEGNAVLQLRPGRGLHKDEEVTISYGADKPASEMIFSYGFLEQERGSAKEILLDLEIPDDDPLKVAKNLFCKSAPGIRLSDAPGAETDSTIWDSPLVWWICVNEEDGLDFEVLQTNDGDRELKATWRGEELKHPGDLNPLLSKDDRWEIFQLRAVVTILDRLESQYYVLRETQIMVGEIKESEDMLALFKSDVFRMINSLRELEGKLLEKGIEYLVQQRQNLITSDAVLAYLNQQQSDDVEEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U677</accession>
    <name>A0A5N6U677_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U677"/>
    <dbReference type="OrthoDB" id="4425826at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="63" mass="7499" checksum="BA1BFC44FBFE8207" modified="2020-04-22" version="1">MLKKIKILQRIQDMIESFNGRQSIPSDYESILEEHLVLVCKPPERLEWKPRNIWAMKSTNKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6D3</accession>
    <name>A0A5N6U6D3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDV25DRAFT_148259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6D3"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAE8154110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="233" mass="25047" checksum="0C89FF436CD0FCD3" modified="2020-04-22" version="1" fragment="single">MDPRFCDNREAGGFSNDGCFAEYMVADAATTVSLPESVSFEQGAPLLCAGATVWGAINKARPFIQPGDTIGIIGIGGLGQLAVQFAKALGYRVVAIDNRNHSLQLTADMSTELQPGLLVNTTHEEATANIMNHTSGEGLAAVINCTDSIQVNAWSLTLLRVGGVAVLLGLPVEQWRFDTKLIVFRELVLRGNYVASKQEVEQMMTVVGQHKIKSQLTVVGKDDIPRVPDTYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6E5</accession>
    <name>A0A5N6U6E5_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_148321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742032">
        <property type="protein sequence ID" value="KAE8154144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6E5"/>
    <dbReference type="OrthoDB" id="4526074at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="180" mass="20662" checksum="4A2F5850A1918678" modified="2020-04-22" version="1">MRNVLGAYTISALMDQAERLRTMSVHLAKSPKLAITQADKIAKWSTKLVNTINKIQRDTEAAALACQKHLYRKIHKLKIQADLQKRKLLDTQELDSSRTIRANFRLIFSPARETEYCSKKAISEVFKAIIGQLKQEKLEEWPEKILDIMNELGDKRPISTEFKALCVKISKCQGCCCRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6U2</accession>
    <name>A0A5N6U6U2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_136022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6U2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="325"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="537"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8154328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="74668" checksum="E17102A167D89DCA" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U6X4</accession>
    <name>A0A5N6U6X4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_135982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742030">
        <property type="protein sequence ID" value="KAE8154290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U6X4"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="688" mass="77299" checksum="A59A994CAE693509" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U750</accession>
    <name>A0A5N6U750_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase, flavin-containing superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_172632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742031">
        <property type="protein sequence ID" value="KAE8154229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U750"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025034887" evidence="1">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="457" mass="50438" checksum="62A6A6E4C3485992" modified="2020-04-22" version="1">MRSISALVLAAISIAVASIPPKNDLKHQHFITRDVAIIGGGSAGTYAAIRLRQMNQSVVVIEKEDNLGGHVDTYTDPATGAAVDFGVLVYEDLPLVRSYFGHFNITLVKVAVAGNATQVRADLRTGTLVGPPPGGMLLALLRYTAQLTRYPWLNTGFNLPDPVPEDLLLPFGEFIRKHQLDGAVDIIAQFNQGVGDILNQTTIYMLKYFGLDVVQGLATGFVQAASHNNSELYGAAERELGPDALLNSQVVNTSSYGDEPWTYLEVASGGGVRIVRARRVIVAIPPKSDLLQALNPDERERRLFDQFQNTCYYATLAKIPGFPPNTMVVNRANETPYQLPPQPSIYLLSPKPGHLTSILYGSETPMTEAQVKQDITQRVLTLRNAGMPVDPPQFVAYSNHTPFLLTVSPDAIRNGFYDELNDLQGHRRRYYMSATMNTHDSAQIWTFIEHMLTEHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7E1</accession>
    <name>A0A5N6U7E1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_171783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7E1"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="687" mass="77546" checksum="5DB0E303FA630658" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7K1</accession>
    <name>A0A5N6U7K1_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDV25DRAFT_171800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7K1"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025027191" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAE8154588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="478" mass="50379" checksum="2C523EDDD251724E" modified="2020-04-22" version="1">MVVLLTALSFAVHVPSALGLTFSVPSEPPENASSQLAAAPVGVSLEFFTFPAYINDVAATETCLQNLKDLTGTWPPLRIGGTTQDRATYDASSTEAVTYSVDDPADAPGTLTYGPPFISLAAEYKGSVILGLNRRLNNQENTISAAALAKDTIDNLYAIELGNEPNFFSDSDPIANGESWTAAADYASQISWQDAVCGNLSASDLISAGVYFGTSPMSIAGLADVEGDANTYVKDYCSHNYPQSPNTADLAGLMGHSDIAGQIQEFAYDISAAAAKGKPHIFGETQSVSATQGGGGISPTFGAGLWILDYVMQTILLGTEALYFHQGTIGNCPYCWWGRYNMGAPYYGAYFATMALANADHIAPLDDQTTPYAAYAIYKNGSPVRVLLYNSDYFAEGTRSSQTFTLTGLTSSTVTAKRLTAPYATSRVDRGQDPTVAGQSFANGTCTIQGEEVVESSSVSSGEASFTVGASEALLVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7U0</accession>
    <name>A0A5N6U7U0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_93729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742027">
        <property type="protein sequence ID" value="KAE8154656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5403573at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="126"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1405"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1324"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1360"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8154656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="1874" mass="210647" checksum="0E30C8F0FC35760F" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U7V0</accession>
    <name>A0A5N6U7V0_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDV25DRAFT_135914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742029">
        <property type="protein sequence ID" value="KAE8154479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U7V0"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAE8154479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="132" mass="14763" checksum="4BF36DCB90BDC0AE" modified="2020-04-22" version="1">MHIMFSTTSGTIRTGIYVNQFVGPNLVHAVLDLLDNPIGPLGSGFKSFSFLYTSETMPMGWVTSSQILHWKEGVPIDVLSGDILFLDPGFSKQAGQNPRLKHPWHDQATECRSEGYFQPHKAKEEMTSTHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U837</accession>
    <name>A0A5N6U837_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ribosomal protein S5 domain 2-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_146947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U837"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000002">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="4" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
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        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="409"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8154772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="524" mass="57806" checksum="331CBE5EFE046D89" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8J0</accession>
    <name>A0A5N6U8J0_ASPAV</name>
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        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDV25DRAFT_147169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus avenaceus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742026">
        <property type="protein sequence ID" value="KAE8154896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8J0"/>
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    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAE8154896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="521" mass="59353" checksum="16550614A78BB1F1" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8R6</accession>
    <name>A0A5N6U8R6_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_146784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742025">
        <property type="protein sequence ID" value="KAE8154976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8R6"/>
    <dbReference type="OrthoDB" id="4516018at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841418" evidence="1">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8154976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="242" mass="26444" checksum="3E1392F1C5F3477C" modified="2020-04-22" version="1">MKCGALALSLASLCLGVFAQDSCITSTPDGYACGSYPNGCPGSGLLSPAGNCKSQFGLVDGSKCCCGCPKEDNPDYRHCVVEVISPKTENINYKTTKANKLGFCQDQKHFIARDPTDLFTFDQCKQAQEEIAKRINAIYKHKGSNYAMPIPNILKKFGKNNQGDTYWIFRVAEMFEKADVRKKTTESCPKLPFGDGKYRAGQCVLEKHNPCLGSLGGLFHVSTDVGYGPKNGVEYDPAWKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6U8T8</accession>
    <name>A0A5N6U8T8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_147431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742028">
        <property type="protein sequence ID" value="KAE8154531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6U8T8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000115">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF228">
        <property type="entry name" value="P450 MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8154531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="495" mass="55902" checksum="65C2891BAA790B5B" modified="2020-04-22" version="1" fragment="single">MAPMTAIATGILVVVLLYKYIIYPYYLSPLSRIPNAHFSAPVSEKWIEKQRNMGKEVLTIYDLHQKHGPVVRLGPNEISVNSLNGLKTIYTGAFEKHPFYSEFFVNFQTPNMVGTIQNNSHARLKRMLSRIYSKSSLQESSDLRDSSRIILSQRLFPTLRDAAKSGDAINVLPLFQAVGMDFTSSFLFGTKNSTTYIFHLPEWQKWLDEYEKFKYMSVEDRFMGFIESWCLSLCRKVENNDQPNNVPIATNAVVYNQLRQSLEKDPDTRPLELSIASEVLDHLVAGHETSGITFTYMMWELSQHPGLQAELRRELLTVTPALKSLSTPDDNGELPSLPSPSALDALPLLDAVLRETLRLHSPAPAPLPRVTPASSTGITIEGYPNIPANVRVSSSSYSLHRIEEIYPRSSEWLPQRWLDAAPGKIHDMRRIFWPFGSGGRMCLGSNFALQEIKLVMAAVYTNFTTEIVDDEGIEQDHAFISLPKGRKLMLKFTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6UAC4</accession>
    <name>A0A5N6UAC4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_135175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742024">
        <property type="protein sequence ID" value="KAE8155131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6UAC4"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8155131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="202" mass="22072" checksum="9948F1C1FC10B878" modified="2020-04-22" version="1">MTDAAGERFLRKHFRSRPDIIDTYFALPSTTHKADFLRYLVLFAEGGVWFDRISCENTPIRDWIPKGFKDVVNLVVGLEADMGLNDDARQFAPWAIMAAPKSPHVLRFINDIVGAVHGAAKGDKLAGLGDVSGLTGPKRFTRAVLESLEISTNGTVDKNGIAHLLRPLLVGDVAIMPGYSFAASLNTYEAGVGTRLVRHHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TCZ7</accession>
    <name>A0A5N6TCZ7_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_167526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742737">
        <property type="protein sequence ID" value="KAE8144157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TCZ7"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="52" mass="5621" checksum="403E727465C25FF9" modified="2020-04-22" version="1">MYHITSTAACTTVYPPFPRPSSNTDGNTIISQLILSLCLTSTFSTTLLLITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDG2</accession>
    <name>A0A5N6TDG2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_171656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742562">
        <property type="protein sequence ID" value="KAE8144342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDG2"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024980189" evidence="2">
        <location>
            <begin position="18"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="285"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="796" mass="88697" checksum="43DD991C94D3DEA6" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TDT2</accession>
    <name>A0A5N6TDT2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_166935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742538">
        <property type="protein sequence ID" value="KAE8144400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TDT2"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="209"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAE8144400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="307" mass="33074" checksum="D9EEAD73C93B7938" modified="2020-04-22" version="1">MAVPEQVPGQEFDYEALPSNYGLGRNMMAGAFAGIAEHAVMYPVDLLKTRMQILHPTTGGLYTGLTNAVSTIYRIEGWRTLWKGVSSVIVGAGPAHAVYFGTYEIVKDMAGGNVDDGHHPVAAALSGASATIASDALMNPFDVIKQRMQVHGSVHKSILQCAKTVYRSEGLQAFYVSYPTTLCMTVPFTATQFVAYESISKVMNPSGDYDPFTHCMAGGLAGAFAAGLTTPLDVVKTLLQTRGMAQNEEIRSAKGLFNAAAIIKRQFGWSGFLRGARPRIISTMPSTAICWTSYEMAKAYFKGQADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TE90</accession>
    <name>A0A5N6TE90_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor Rba50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_166242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742454">
        <property type="protein sequence ID" value="KAE8144688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TE90"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="447" mass="48200" checksum="82F972571B15C09D" modified="2020-04-22" version="1">MAFRGERFVLDLDSDDDQTSYTLPTSPLAIPGMIGEIRERSPAVAPAPPKPSPAGFPAHRRRAKHSTFKQRREASATTPRNETSPMDEKSTIHEANRQQIASMSDAQIQQEREELMSSLDPSLLERFLRRARIDSEDYDTGPQSITSQPTEQDTSAEALCRSEPISQPEPSIPQENQTQRDDLPPTQKPDDLHPAVDSPLPSSVHFPTPPSRSNPMPNLDPSSPSFLSDLQAHYFPNITHDPSALSWLQPPSADSDAPDATSAYHPASSAEALHPSAIRFSFLGTLLSPSTSLSLPTNLGLHHHGNDPHAAGYTIPEIAILSRSSFPAQRCVAWQVLGRILFRLGKGQFGERGSTLVEGLWSVIEHEGVVAGMLAEADGASTGAARGANKVSTASKQQRQEQDSSGTTGGVGRHASATAWAVEGVWLWQMSGSGDRGVLKAGAVRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEC3</accession>
    <name>A0A5N6TEC3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_145461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742479">
        <property type="protein sequence ID" value="KAE8144600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEC3"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="428" mass="46650" checksum="36E05DF58CEB57DB" modified="2020-04-22" version="1">MVATDLDHQQFLQNHQIGISSPKMKPEPGVSEAGEQPVLSYPPHAPLSQMPNMPQDMRYAHQTHPNTGLPLLQDPYVAGYPGPQMANGGGPQGRTDPPPKTFHCGTCNKGFARRSDLARHERIHSGIRPHACDWPGCGKQFIQRSALTVHSRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYANCQKTFTRRTTLTRHQNHHTGTIEEAAAETEANLRQNKERARMPGDGMFSEHASVHSTPSPAHHPAISPAGDLPPLNMPPRTAGDYFMGNGTIPPHVRGDFSQASPRASPTATSPSLSSFSSAPHTRPSMTSHPSGYGPPQPLEPPANNDHRPNSVSGSPHMTSLGWASPSHGSIPSPGSANDFGYPDPNGPAYPNTIPPHMYFPNSTIRRPTSTEPENYEMKPKVSEHAWSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TED1</accession>
    <name>A0A5N6TED1_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDV25DRAFT_166236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742453">
        <property type="protein sequence ID" value="KAE8144692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TED1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAE8144692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="567" mass="61591" checksum="F508EDE2D8E6EEC8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEG8</accession>
    <name>A0A5N6TEG8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal pheromone mating factor STE2 GPCR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDV25DRAFT_91922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IBT 18842</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML742501">
        <property type="protein sequence ID" value="KAE8144501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEG8"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAE8144501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="373" mass="41724" checksum="3A7BD095044A0EE9" modified="2020-04-22" version="1">MSSVNFDPYTQNLTFRHANGTPFNVTVELLRDDWYQYSLQTCINYAAQLGASIAVFIILMLLTRPEKRGSSVFFLNSGALLLNISRLLCNIIYFRTDFVGPYQWFSGDQSRTPASAYANSILGVVFLTLLIVCIEVSLVLQVQVVCANLRRRYRTILVYVSLLVALTPIGFRMAYMVKNCMTIMKAISPDQLHWLESATNIVLTISICFFSTVFIIKLGLAIYHRRRLGVRDFGPMKVIFIMGCQTLIVPALFSTMQYAVDVPQLASNVITLVTISLPLSSIWAGITLRQSSTRSSTSRGALWDRLALTSSMKSKQTTITSSTAIIDVSNKPSTFCYADQPSGQSQHDLRHGPGISVERDITVHSYHRDEPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TEL0</accession>
    <name>A0A5N6TEL0_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDV25DRAFT_166157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742445">
        <property type="protein sequence ID" value="KAE8144737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TEL0"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAE8144737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="226" mass="25544" checksum="6FD5E8CA2E0B8668" modified="2020-04-22" version="1">MASSHSVARLVAYRRPTPFLISSSFRPLTPTANFSSSVCRSATPTGPPPAGFRLPTPKKWDEGSESSLDKASKYFLMSEIFRGMYVVLEQFFRPPYTIFYPFEKGPISPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEEREDGSRRTTRYDIDMTKCIYCGYCQESCPVDAIVETSNAEYATETREELLYNKEKLLANGDKWEPEIAAAARADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TES4</accession>
    <name>A0A5N6TES4_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_165916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KAE8144868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TES4"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="653"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAE8144868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="89956" checksum="95197E0C41EC33B8" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TES8</accession>
    <name>A0A5N6TES8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_166135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742442">
        <property type="protein sequence ID" value="KAE8144760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TES8"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8144760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="98" mass="10999" checksum="C8EAD54B80BA33AE" modified="2020-04-22" version="1">MADSSSNNTSNEKQMRLVALRISIENLNSEIARVEAQRAETRASLNNDPSATLQRHIQLLHDYNEIKDTGQGLMSLIADARGMRQADVEKEYGINVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TF67</accession>
    <name>A0A5N6TF67_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_134184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742405">
        <property type="protein sequence ID" value="KAE8144982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TF67"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="199"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8144982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="525" mass="59269" checksum="F5D6008B437867A4" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFC3</accession>
    <name>A0A5N6TFC3_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDV25DRAFT_165448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IBT 18842</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="ML742391">
        <property type="protein sequence ID" value="KAE8145068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFC3"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAE8145068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="502" mass="55684" checksum="E4A1E7949EB77CD4" modified="2020-04-22" version="1">MAAAIKETVSNLIHGHSENALRQPSPEEFQQLQQKYTEAGQGHVFAFVEQLNQTEKTQLFHQLNNFDPVRINELADKVLNPTKAEEGPISLEPLPEVATASILDSDPKDIQRWYDEGLRAVAENKVAVVLMAGGQGTRLGSSAPKGCFDIGLPSHKSLFQIQAERIGKLQKLSGKDAVIPWYVMTSGPTRKPTEDFFEQNNYFGLDKKNVVIFEQGVLPCISNEGKILLESKAKAAVAPDGNGGIYQALITSGVREDMRKRGIEHIHTYCVDNCLVKVADPVFIGFAASKDVDIATKVVRKRNATESVGLILQKNGKPDVVEYSEIDQETAEAKDPKQPDVLKFRAANIVNHYYSFRFFESIENWAHKLPHHVARKKIPCVNIENGESFKPEKPNGIKLEQFVFDVFPMTPLDKFACIEVRRDDEFSPLKNAKGTGEDDPDTSKRDIMSQGQRWIEKAGGVVVTEGEAVGVEVSPLISYGGEGLEFLKGREIKAPAVIEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TFC4</accession>
    <name>A0A5N6TFC4_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glial factor naturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDV25DRAFT_165437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML742390">
        <property type="protein sequence ID" value="KAE8145075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TFC4"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAE8145075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="141" mass="16130" checksum="28E2BE5205876D55" modified="2020-04-22" version="1">MSESRLYTFSPETKEKLRKFRLGTSRAKDPQAVIYVIDQKSQEIRPQDGEVYTKMEDLADELPESSPRFILLSYPLTLGSGRLAVPYVLLYYLPENCNPSMRMMYAGAVELMRNTAEVNRVIDVQDEEDVISIESKLQSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGL2</accession>
    <name>A0A5N6TGL2_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDV25DRAFT_170478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IBT 18842</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML742341">
        <property type="protein sequence ID" value="KAE8145483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGL2"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAE8145483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="608" mass="69120" checksum="B6F537C8F2BE2F50" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGV8</accession>
    <name>A0A5N6TGV8_ASPAV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tho complex subunit 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDV25DRAFT_164622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IBT 18842</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML742342">
        <property type="protein sequence ID" value="KAE8145480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGV8"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAE8145480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000325780"/>
        </source>
    </evidence>
    <sequence length="339" mass="38552" checksum="A0AB9F7CF1F1ECA0" modified="2020-04-22" version="1">MASYGLLDQPEEDALHKLRLLNVEEKPFKRISKRLLNPDSLTVSNATLPPTPPPEGTSEDADAEKQQKLEQWRHFREDVTLDFAAFESSIARIQFLLTSNEKERERYAAEKLRILSTMQSVRENTADLRVQLEEAQRLLALRKSYDDLAEKITSNRLLKPREDQQANLQKLQAEITELEKESKDYAKTWAERREQFGRIVEEGMQLRRLIRDEKEEVERREGMQEGEDGDDGDVPSKGKSSGANTPRPESDSATPSQQAHEEANRSFSALQAERVNATGAASPLRQVTLAEDEKKQSPEHDTNMVDEGEVTGDENTENPDELEEGEEQDDQTADKMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N6TGZ2</accession>
    <name>A0A5N6TGZ2_ASPAV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDV25DRAFT_133850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus avenaceus</name>
        <dbReference type="NCBI Taxonomy" id="36643"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-04" db="EMBL/GenBank/DDBJ databases">
            <title>Friends and foes A comparative genomics study of 23 Aspergillus species from section Flavi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Kjaerbolling I."/>
                <person name="Vesth T."/>
                <person name="Frisvad J.C."/>
                <person name="Nybo J.L."/>
                <person name="Theobald S."/>
                <person name="Kildgaard S."/>
                <person name="Isbrandt T."/>
                <person name="Kuo A."/>
                <person name="Sato A."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Wiebenga A."/>
                <person name="Kun R.S."/>
                <person name="Lubbers R.J."/>
                <person name="Makela M.R."/>
                <person name="Barry K."/>
                <person name="Chovatia M."/>
                <person name="Clum A."/>
                <person name="Daum C."/>
                <person name="Haridas S."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Mondo S."/>
                <person name="Riley R."/>
                <person name="Salamov A."/>
                <person name="Simmons B.A."/>
                <person name="Magnuson J.K."/>
                <person name="Henrissat B."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Devries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Machida M."/>
                <person name="Baker S.E."/>
                <person name="Andersen M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IBT 18842</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="ML742354">
        <property type="protein sequence ID" value="KAE8145361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N6TGZ2"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000325780">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosyn